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AU2004232939A1 - Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity - Google Patents

Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity Download PDF

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Publication number
AU2004232939A1
AU2004232939A1 AU2004232939A AU2004232939A AU2004232939A1 AU 2004232939 A1 AU2004232939 A1 AU 2004232939A1 AU 2004232939 A AU2004232939 A AU 2004232939A AU 2004232939 A AU2004232939 A AU 2004232939A AU 2004232939 A1 AU2004232939 A1 AU 2004232939A1
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Australia
Prior art keywords
6alkyl
mmol
substituents
substituted
pct
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Abandoned
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AU2004232939A
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English (en)
Inventor
Gabor Butora
Stephen D. Goble
Christopher R. Moyes
Alexander Pasternak
Lihu Yang
Changyou Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
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Publication of AU2004232939A1 publication Critical patent/AU2004232939A1/en
Assigned to MERCK SHARP & DOHME CORP., MERCK SHARP & DOHME LIMITED reassignment MERCK SHARP & DOHME CORP. Alteration of Name(s) of Applicant(s) under S113 Assignors: MERCK & CO., INC., MERCK SHARP & DOHME LIMITED
Abandoned legal-status Critical Current

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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AU2004232939A 2003-04-17 2004-04-14 Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity Abandoned AU2004232939A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46367303P 2003-04-17 2003-04-17
US60/463,673 2003-04-17
PCT/US2004/011463 WO2004094371A2 (fr) 2003-04-17 2004-04-14 Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine

Publications (1)

Publication Number Publication Date
AU2004232939A1 true AU2004232939A1 (en) 2004-11-04

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AU2004232939A Abandoned AU2004232939A1 (en) 2003-04-17 2004-04-14 Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity

Country Status (6)

Country Link
EP (1) EP1622916A4 (fr)
JP (1) JP2006523704A (fr)
CN (1) CN100384856C (fr)
AU (1) AU2004232939A1 (fr)
CA (1) CA2521625A1 (fr)
WO (1) WO2004094371A2 (fr)

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US8058288B2 (en) 2004-05-07 2011-11-15 Incyte Corporation Amido compounds and their use as pharmaceuticals

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AU2004232939A1 (en) * 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
US7598243B2 (en) 2003-04-17 2009-10-06 Merck & Co., Inc. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
CA2649636A1 (fr) * 2006-04-20 2007-11-01 F. Hoffmann-La Roche Ag Derives du diazepan modulateurs des recepteurs de la chimiokine
EP2123644B1 (fr) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Dérivés de benzodiazépine et utilisation de ces derniers
SMT201700456T1 (it) 2009-07-27 2017-11-15 Gilead Sciences Inc Composti eterociclici fusi come modulatori dei canali ionici
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
JP5858586B2 (ja) 2010-07-02 2016-02-10 ギリアード サイエンシーズ， インコーポレイテッド イオンチャネルモジュレーターとしての縮合複素環式化合物
TWI577670B (zh) 2011-05-10 2017-04-11 基利科學股份有限公司 充當離子通道調節劑之稠合雜環化合物
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (fr) 2011-07-01 2018-04-28
RS62809B1 (sr) 2015-05-21 2022-02-28 Chemocentryx Inc Modulatori ccr2
WO2018026763A1 (fr) 2016-08-01 2018-02-08 Aptinyx Inc. Modulateurs spiro-lactames des récepteurs nmda et leurs utilisations
SG11201900554YA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda modulators and methods of using same
MX383650B (es) 2016-08-01 2025-03-14 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos.
US11304952B2 (en) 2017-09-25 2022-04-19 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
EP3737367B1 (fr) 2018-01-08 2024-10-02 ChemoCentryx, Inc. Antagonistes du ccr2 pour le traitement du lymphome cutané à cellules t
CN112204031B (zh) * 2018-01-31 2024-05-24 元羿生物科技(香港)有限公司 螺-内酰胺nmda受体调节剂及其用途
CN111056955B (zh) * 2019-12-16 2021-05-25 中国科学院大连化学物理研究所 一种环己烯制备己二胺的方法
CN117342958B (zh) * 2023-09-12 2025-12-16 武汉理工大学 一种埋底界面材料及其制备得到的柔性钙钛矿太阳能电池

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Publication number Priority date Publication date Assignee Title
WO2002013824A1 (fr) * 2000-08-17 2002-02-21 Merck & Co., Inc. Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
ES2306867T3 (es) * 2002-04-29 2008-11-16 MERCK & CO., INC. Moduladores de la actividad receptora de quimiocinas de tetrahidro-piranil-ciclopentil-tetrahidropiridopiridina.
EP1501803B1 (fr) * 2002-04-29 2008-08-13 Merck & Co., Inc. Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline
AU2004232939A1 (en) * 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US9126927B2 (en) 2004-05-07 2015-09-08 Incyte Holdings Corporation Amido compounds and their use as pharmaceuticals
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US9957229B2 (en) 2004-05-07 2018-05-01 Incyte Holdings Corporation Amido compounds and their use as pharmaceuticals

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JP2006523704A (ja) 2006-10-19
CA2521625A1 (fr) 2004-11-04
EP1622916A2 (fr) 2006-02-08
WO2004094371A2 (fr) 2004-11-04
CN1805965A (zh) 2006-07-19
CN100384856C (zh) 2008-04-30
WO2004094371A3 (fr) 2005-03-24

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