|
IL159120A0
(en)
|
2001-05-29 |
2004-05-12 |
Schering Ag |
Cdk inhibiting pyrimidines, production thereof and their use as medicaments
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
CN103169708B
(en)
|
2002-07-29 |
2018-02-02 |
里格尔药品股份有限公司 |
The method that autoimmune disease is treated or prevented with 2,4 pyrimidinediamine compounds
|
|
UA80767C2
(en)
*
|
2002-12-20 |
2007-10-25 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
MXPA06002608A
(en)
|
2002-12-20 |
2007-01-23 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth.
|
|
US7109337B2
(en)
|
2002-12-20 |
2006-09-19 |
Pfizer Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
US7122542B2
(en)
|
2003-07-30 |
2006-10-17 |
Rigel Pharmaceuticals, Inc. |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
|
|
JP4607879B2
(en)
*
|
2003-08-15 |
2011-01-05 |
ノバルティス アーゲー |
2,4-Pyrimidinediamine useful for the treatment of neoplastic diseases, inflammation and immune disorders
|
|
CA2566332A1
(en)
|
2004-05-14 |
2005-11-24 |
Pfizer Products Inc. |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
WO2005111016A1
(en)
|
2004-05-14 |
2005-11-24 |
Pfizer Products Inc. |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
JP2007537235A
(en)
|
2004-05-14 |
2007-12-20 |
ファイザー・プロダクツ・インク |
Pyrimidine derivatives for the treatment of abnormal cell proliferation
|
|
WO2006004776A1
(en)
*
|
2004-06-29 |
2006-01-12 |
Rigel Pharmaceuticals, Inc. |
4-pyrimidineamine compounds and their uses as anti-proliferative agents
|
|
US20060051406A1
(en)
*
|
2004-07-23 |
2006-03-09 |
Manjeet Parmar |
Formulation of insoluble small molecule therapeutics in lipid-based carriers
|
|
GB0419161D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
|
GB0419160D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
|
AU2005289426A1
(en)
*
|
2004-09-27 |
2006-04-06 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
ATE540035T1
(en)
|
2004-11-24 |
2012-01-15 |
Rigel Pharmaceuticals Inc |
SPIRO-2,4-PYRIMIDINEDIAMINE COMPOUNDS AND USES THEREOF
|
|
US7449458B2
(en)
|
2005-01-19 |
2008-11-11 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
US20060247263A1
(en)
*
|
2005-04-19 |
2006-11-02 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
KR100602320B1
(en)
*
|
2005-05-03 |
2006-07-18 |
주식회사 하이닉스반도체 |
Nonvolatile Memory Devices with Uniform Program Speed
|
|
RU2485106C2
(en)
|
2005-06-08 |
2013-06-20 |
Райджел Фамэсьютикэлз, Инк. |
Compounds exhibiting jak-kinase activity (versions), method of treating jak-kinase mediated diseases, method of inhibiting jak-kinase activity (versions), pharmaceutical composition of said compounds
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
MY167260A
(en)
|
2005-11-01 |
2018-08-14 |
Targegen Inc |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
WO2007111720A2
(en)
|
2005-12-06 |
2007-10-04 |
Rigel Pharmaceuticals, Inc. |
Formulation of insoluble small molecule therapeutics in lipid-based carriers
|
|
EA014551B1
(en)
|
2005-12-21 |
2010-12-30 |
Пфайзер Продактс Инк. |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
TW200736232A
(en)
*
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
US8962643B2
(en)
|
2006-02-24 |
2015-02-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
CN101438288A
(en)
*
|
2006-03-15 |
2009-05-20 |
Csir公司 |
Regulation of phosphoryltransferase activity of glutamine synthetase
|
|
GB2451594A
(en)
*
|
2006-03-15 |
2009-02-04 |
Csir |
Modulation of phosphoryl transferase activity of glutamine synthetase
|
|
CA2673125C
(en)
|
2006-10-19 |
2015-04-21 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
JP5512274B2
(en)
|
2006-10-23 |
2014-06-04 |
セファロン、インク. |
Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK inhibitors and c-MET inhibitors
|
|
RS53588B1
(en)
|
2006-12-08 |
2015-02-27 |
Irm Llc |
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
|
|
EP1939185A1
(en)
*
|
2006-12-20 |
2008-07-02 |
Bayer Schering Pharma Aktiengesellschaft |
New types of hetaryl-phenylendiamin-pyrimidines as protein kinase inhibitors for the treatment of cancer
|
|
US20080153863A1
(en)
|
2006-12-22 |
2008-06-26 |
Caterina Bissantz |
Spiropiperidine derivatives
|
|
FR2911137B1
(en)
*
|
2007-01-05 |
2009-02-20 |
Sanofi Aventis Sa |
NOVEL 2,4-DIANILINOPYRIMIDE DERIVATIVES, THEIR PREPARATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS INHIBITORS OF IKK
|
|
WO2008106635A1
(en)
*
|
2007-03-01 |
2008-09-04 |
Supergen, Inc. |
Pyrimidine-2,4-diamine derivatives and their use as jak2 kinase inhibitors
|
|
EP1969929A1
(en)
|
2007-03-12 |
2008-09-17 |
Bayer CropScience AG |
Substituted phenylamidines and their use as fungicides
|
|
JP4782239B2
(en)
*
|
2007-04-18 |
2011-09-28 |
ファイザー・プロダクツ・インク |
Sulfonylamide derivatives for the treatment of abnormal cell proliferation
|
|
AU2014201847B2
(en)
*
|
2007-04-18 |
2015-12-24 |
Pfizer Products Inc. |
Sulfonyl amide derivatives for the treatment of abnormal cell growth
|
|
AU2016201820B2
(en)
*
|
2007-04-18 |
2018-03-08 |
Pfizer Products Inc. |
Sulfonyl amide derivatives for the treatment of abnormal cell growth
|
|
EP2231620A1
(en)
|
2007-12-03 |
2010-09-29 |
Boehringer Ingelheim International GmbH |
Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
|
|
ATE535515T1
(en)
|
2008-01-11 |
2011-12-15 |
Hoffmann La Roche |
MODULATORS FOR AMYLOID BETA
|
|
RU2010137300A
(en)
*
|
2008-02-22 |
2012-03-27 |
Ф. Хоффманн-Ля Рош Аг (Ch) |
BETA AMYLOID MODULATORS
|
|
PT2323993E
(en)
|
2008-04-16 |
2015-10-12 |
Portola Pharm Inc |
2,6-diamino- pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors
|
|
KR20100132550A
(en)
|
2008-04-16 |
2010-12-17 |
포톨라 파마슈티컬스, 인코포레이티드 |
2,6-diamino-pyrimidin-5-yl-carboxamide as an xsy or yak kinase inhibitor
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US8258144B2
(en)
|
2008-04-22 |
2012-09-04 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
PT2300013T
(en)
|
2008-05-21 |
2017-10-31 |
Ariad Pharma Inc |
Phosphorous derivatives as kinase inhibitors
|
|
DE102008049323A1
(en)
*
|
2008-09-29 |
2010-04-01 |
Henkel Ag & Co. Kgaa |
New developer components
|
|
CN102177151A
(en)
|
2008-10-09 |
2011-09-07 |
弗·哈夫曼-拉罗切有限公司 |
Modulators for amyloid beta
|
|
MX2011004954A
(en)
|
2008-11-10 |
2011-05-30 |
Hoffmann La Roche |
Heterocyclic gamma secretase modulators.
|
|
CN102292333B
(en)
*
|
2009-01-15 |
2015-05-13 |
里格尔药品股份有限公司 |
Protein kinase c inhibitors and uses thereof
|
|
WO2011018517A1
(en)
|
2009-08-14 |
2011-02-17 |
Boehringer Ingelheim International Gmbh |
Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
|
|
US8933227B2
(en)
|
2009-08-14 |
2015-01-13 |
Boehringer Ingelheim International Gmbh |
Selective synthesis of functionalized pyrimidines
|
|
CA2784807C
(en)
|
2009-12-29 |
2021-12-14 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
|
US8486967B2
(en)
|
2010-02-17 |
2013-07-16 |
Hoffmann-La Roche Inc. |
Heteroaryl substituted piperidines
|
|
WO2011144742A1
(en)
|
2010-05-21 |
2011-11-24 |
Chemilia Ab |
Novel pyrimidine derivatives
|
|
EP2975027A1
(en)
|
2010-11-01 |
2016-01-20 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as jak kinase modulators
|
|
US20130317029A1
(en)
|
2010-11-01 |
2013-11-28 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
CA2816219C
(en)
|
2010-11-01 |
2019-10-29 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as syk modulators
|
|
WO2012060847A1
(en)
|
2010-11-07 |
2012-05-10 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
|
EP2688883B1
(en)
|
2011-03-24 |
2016-05-18 |
Noviga Research AB |
Pyrimidine derivatives
|
|
US9249124B2
(en)
|
2011-03-30 |
2016-02-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Aurora kinase inhibitors and methods of making and using thereof
|
|
EP2704572B1
(en)
|
2011-05-04 |
2015-12-30 |
Ariad Pharmaceuticals, Inc. |
Compounds for inhibiting cell proliferation in egfr-driven cancers
|
|
US9416132B2
(en)
|
2011-07-21 |
2016-08-16 |
Tolero Pharmaceuticals, Inc. |
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
|
|
WO2013074986A1
(en)
*
|
2011-11-17 |
2013-05-23 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
|
US8877760B2
(en)
|
2011-11-23 |
2014-11-04 |
Portola Pharmaceuticals, Inc. |
Substituted pyrazine-2-carboxamide kinase inhibitors
|
|
EP2606884A1
(en)
*
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
|
AU2013204563B2
(en)
|
2012-05-05 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
|
KR101446742B1
(en)
*
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine derivatives or pharmaceutically acceptable salt thereof, and pharmaceutical composition for the prevention or treatment of cancer containing the same as an active ingredient
|
|
EP2903970A4
(en)
|
2012-10-08 |
2016-11-30 |
Portola Pharm Inc |
Substituted pyrimidinyl kinase inhibitors
|
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
DK2970205T3
(en)
*
|
2013-03-14 |
2019-07-29 |
Tolero Pharmaceuticals Inc |
JAK2 and ALK2 inhibitors and methods for their use
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
JP6491202B2
(en)
|
2013-10-18 |
2019-03-27 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
Polycyclic inhibitors of cyclin dependent kinase 7 (CDK 7)
|
|
CA2927917C
(en)
|
2013-10-18 |
2022-08-09 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of proliferative diseases
|
|
US10106507B2
(en)
*
|
2014-08-03 |
2018-10-23 |
H. Lee Moffitt Cancer Center and Research Insitute, Inc. |
Potent dual BRD4-kinase inhibitors as cancer therapeutics
|
|
EP3236959B1
(en)
|
2014-12-23 |
2025-09-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
CA2978518C
(en)
|
2015-03-27 |
2023-11-21 |
Nathanael S. Gray |
Inhibitors of cyclin-dependent kinases
|
|
JP7028766B2
(en)
|
2015-09-09 |
2022-03-02 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
Inhibitor of cyclin-dependent kinase
|
|
WO2017066428A1
(en)
|
2015-10-13 |
2017-04-20 |
H. Lee Moffitt Cancer Center & Research Institute, Inc. |
Brd4-kinase inhibitors as cancer therapeutics
|
|
CN111163839B
(en)
|
2017-05-26 |
2024-05-28 |
癌症研究科技有限公司 |
Benzimidazolone-derived BCL6 inhibitors
|
|
JP7311228B2
(en)
|
2017-06-30 |
2023-07-19 |
ベイジン タイド ファーマシューティカル カンパニー リミテッド |
RHO-related protein kinase inhibitors, pharmaceutical compositions containing same and methods for preparation and use thereof
|
|
WO2019000683A1
(en)
|
2017-06-30 |
2019-01-03 |
北京泰德制药股份有限公司 |
Rho-associated protein kinase inhibitor, pharmaceutical composition containing rho-associated protein kinase inhibitor, preparation method and use of the pharmaceutical composition
|
|
EP3421465B1
(en)
|
2017-06-30 |
2022-10-26 |
Beijing Tide Pharmaceutical Co., Ltd. |
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
|
|
CN109776522B
(en)
*
|
2017-10-30 |
2020-12-29 |
广东东阳光药业有限公司 |
Substituted heteroaryl compounds and compositions and uses thereof
|
|
WO2019195753A1
(en)
|
2018-04-05 |
2019-10-10 |
Tolero Pharmaceuticals, Inc. |
Axl kinase inhibitors and use of the same
|
|
EP3773560A4
(en)
|
2018-04-13 |
2022-01-19 |
Sumitomo Dainippon Pharma Oncology, Inc. |
PIM-KINASE INHIBITORS FOR THE TREATMENT OF CANCER-ASSOCIATED MYELOPROLIFERATIVE NEOPLASMA AND FIBROSIS
|
|
JP7493454B2
(en)
|
2018-04-13 |
2024-05-31 |
キャンサー・リサーチ・テクノロジー・リミテッド |
BCL6 inhibitors
|
|
WO2020005807A1
(en)
|
2018-06-25 |
2020-01-02 |
Dana-Farber Cancer Institute, Inc. |
Taire family kinase inhibitors and uses thereof
|
|
WO2020006724A1
(en)
*
|
2018-07-05 |
2020-01-09 |
清华大学 |
Compound for targeted degradation of fak protein and use thereof
|
|
CN112512597A
(en)
|
2018-07-26 |
2021-03-16 |
大日本住友制药肿瘤公司 |
Methods for treating diseases associated with aberrant ACVR1 expression and ACVR1 inhibitors useful therefor
|
|
CN111362922A
(en)
|
2018-12-26 |
2020-07-03 |
上海喆邺生物科技有限公司 |
2,4-Diaminopyrimidine derivatives and uses thereof
|
|
CA3127502A1
(en)
|
2019-02-12 |
2020-08-20 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
|
CN114105887B
(en)
*
|
2021-09-16 |
2023-12-01 |
沈阳药科大学 |
Aminopyrimidine derivative and preparation method and application thereof
|
|
AU2023372386A1
(en)
|
2022-10-31 |
2025-05-08 |
Sumitomo Pharma America, Inc. |
Pim1 inhibitor for treating myeloproliferative neoplasms
|