AU2003229835A1 - Compounds, compositions and method for transporting cyclosporin molecules through the blood brain barrier - Google Patents
Compounds, compositions and method for transporting cyclosporin molecules through the blood brain barrierInfo
- Publication number
- AU2003229835A1 AU2003229835A1 AU2003229835A AU2003229835A AU2003229835A1 AU 2003229835 A1 AU2003229835 A1 AU 2003229835A1 AU 2003229835 A AU2003229835 A AU 2003229835A AU 2003229835 A AU2003229835 A AU 2003229835A AU 2003229835 A1 AU2003229835 A1 AU 2003229835A1
- Authority
- AU
- Australia
- Prior art keywords
- transporting
- compositions
- compounds
- brain barrier
- blood brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 229930105110 Cyclosporin A Natural products 0.000 title 1
- 108010036949 Cyclosporine Proteins 0.000 title 1
- 230000008499 blood brain barrier function Effects 0.000 title 1
- 210000001218 blood-brain barrier Anatomy 0.000 title 1
- 229960001265 ciclosporin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR02/02299 | 2002-02-22 | ||
| FR0202299A FR2836474B1 (en) | 2002-02-22 | 2002-02-22 | COMPOUNDS, COMPOSITIONS AND METHOD FOR TRANSPORTING CYCLOSPORIN MOLECULES THROUGH THE HEMATOENCEPHALIC BARRIER |
| PCT/FR2003/000591 WO2003070755A2 (en) | 2002-02-22 | 2003-02-24 | Compounds, compositions and method for transporting cyclosporin molecules through the blood brain barrier |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003229835A1 true AU2003229835A1 (en) | 2003-09-09 |
| AU2003229835A8 AU2003229835A8 (en) | 2003-09-09 |
Family
ID=27676020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003229835A Abandoned AU2003229835A1 (en) | 2002-02-22 | 2003-02-24 | Compounds, compositions and method for transporting cyclosporin molecules through the blood brain barrier |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2003229835A1 (en) |
| FR (1) | FR2836474B1 (en) |
| WO (1) | WO2003070755A2 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2851471B1 (en) * | 2003-02-24 | 2006-07-28 | Synt Em | COMPOUNDS COMPRISING AT LEAST ONE ACTIVE SUBSTANCE AND AT LEAST ONE VECTOR CONNECTED BY A BINDING AGENT, USES THEREOF AND THE BINDING AGENTS |
| JP2006524232A (en) | 2003-03-17 | 2006-10-26 | アルバニー モレキュラー リサーチ インコーポレーティッド | New cyclosporine |
| EP1682114A2 (en) | 2003-10-27 | 2006-07-26 | City of Hope | Methods of lowering lipid levels in a mammal |
| US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
| JP2008514701A (en) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | Cyclosporine alkyne analogs and their pharmaceutical use |
| WO2006041631A2 (en) | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| WO2007027559A2 (en) * | 2005-08-29 | 2007-03-08 | Shashoua Victor E | Neuroprotective and neurorestorative methods and compositions |
| EP1810675A1 (en) * | 2006-01-18 | 2007-07-25 | Institut Curie | Method for treating Huntington's disease by inhibiting dephosphorylation of huntingtin at S421 |
| WO2007094026A1 (en) * | 2006-02-17 | 2007-08-23 | Paolo La Colla | Prophylactic and/or therapeutic treatment of proliferative and conformational diseases |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| DE102008060549A1 (en) * | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Drug-peptide construct for extracellular accumulation |
| FR2968662B1 (en) | 2010-12-10 | 2013-11-22 | Roussy Inst Gustave | NOVEL PRE-ACTIVE OXAZAPHOSPHORINE DERIVATIVES, USE AND METHOD OF PREPARATION |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| PL3149025T3 (en) | 2014-05-21 | 2019-11-29 | Entrada Therapeutics Inc | Cell penetrating peptides and methods of making and using thereof |
| EP3185880B1 (en) | 2014-08-27 | 2020-02-12 | Ohio State Innovation Foundation | Improved peptidyl calcineurin inhibitors |
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| WO2019148194A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Peptidyl inhibitors of calcineurin-nfat interaction |
| EP3755351A4 (en) | 2018-02-22 | 2021-11-24 | Entrada Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY |
| EP3790890A4 (en) | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | CYCLIC, CELL-PENETRATING PEPTIDES WITH ONE OR MORE HYDROPHOBIC RAILS |
| CN113952468B (en) * | 2021-09-26 | 2023-07-07 | 中国人民解放军空军军医大学 | A cyclosporine A nano drug for the treatment of myocardial ischemia-reperfusion injury |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001667A1 (en) * | 1990-07-25 | 1992-02-06 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
| FR2767323B1 (en) * | 1997-08-12 | 2001-01-05 | Synt Em | LINEAR PEPTIDES DERIVED FROM ANTIBIOTIC PEPTIDES, THEIR PREPARATION AND THEIR USE FOR VECTORIZING ACTIVE SUBSTANCES |
| MXPA02001857A (en) * | 1999-08-24 | 2003-07-14 | Cellgate Inc | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties. |
| US6669951B2 (en) * | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
-
2002
- 2002-02-22 FR FR0202299A patent/FR2836474B1/en not_active Expired - Fee Related
-
2003
- 2003-02-24 AU AU2003229835A patent/AU2003229835A1/en not_active Abandoned
- 2003-02-24 WO PCT/FR2003/000591 patent/WO2003070755A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003070755A2 (en) | 2003-08-28 |
| AU2003229835A8 (en) | 2003-09-09 |
| FR2836474B1 (en) | 2004-12-24 |
| FR2836474A1 (en) | 2003-08-29 |
| WO2003070755A3 (en) | 2004-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |