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AU2003228431A1 - Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells - Google Patents

Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells

Info

Publication number
AU2003228431A1
AU2003228431A1 AU2003228431A AU2003228431A AU2003228431A1 AU 2003228431 A1 AU2003228431 A1 AU 2003228431A1 AU 2003228431 A AU2003228431 A AU 2003228431A AU 2003228431 A AU2003228431 A AU 2003228431A AU 2003228431 A1 AU2003228431 A1 AU 2003228431A1
Authority
AU
Australia
Prior art keywords
melecules
hmgn2
peptides
tumor
blood vessels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003228431A
Other versions
AU2003228431A8 (en
Inventor
Sven Christian
Kimmo Porkka
Erkki Ruoslahti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/400,083 external-priority patent/US7544767B2/en
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of AU2003228431A1 publication Critical patent/AU2003228431A1/en
Publication of AU2003228431A8 publication Critical patent/AU2003228431A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003228431A 2002-04-05 2003-04-02 Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells Abandoned AU2003228431A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11686602A 2002-04-05 2002-04-05
US10/116,866 2002-04-05
US10/400,083 US7544767B2 (en) 2002-04-05 2003-03-20 HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
US10/400,083 2003-03-20
PCT/US2003/010240 WO2003087124A2 (en) 2002-04-05 2003-04-02 Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells

Publications (2)

Publication Number Publication Date
AU2003228431A1 true AU2003228431A1 (en) 2003-10-27
AU2003228431A8 AU2003228431A8 (en) 2003-10-27

Family

ID=29253938

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003228431A Abandoned AU2003228431A1 (en) 2002-04-05 2003-04-02 Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells

Country Status (2)

Country Link
AU (1) AU2003228431A1 (en)
WO (1) WO2003087124A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004279837B2 (en) * 2003-10-09 2010-04-01 University Of Louisville Research Foundation, Inc. A method for the treatment of malignant diseases by inhibiting nucleolin

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541150B2 (en) 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
CN1862258B (en) * 2005-05-12 2012-05-30 清华大学 Nucleolin-assisted cancer diagnosis and treatment
US8231895B2 (en) 2008-05-22 2012-07-31 Universidade De Coimbra Targeted delivery to human diseases and disorders
JP6174320B2 (en) 2009-11-17 2017-08-02 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント Human monoclonal antibody against human nucleolin
WO2011119058A2 (en) 2010-03-22 2011-09-29 Universidade De Coimbra F3-peptide targeted lipid-based nanoparticles useful for the treatment of angiogenesis-dependent diseases
US20110262347A1 (en) * 2010-04-08 2011-10-27 The Salk Institute For Biological Studies Methods and compositions for enhanced delivery of compounds
WO2012167173A1 (en) 2011-06-02 2012-12-06 The University Of Louisville Research Foundation, Inc. Anti-nucleolin agent-conjugated nanoparticles
WO2016127346A1 (en) * 2015-02-11 2016-08-18 四川大学华西医院 Tumour necrosis factor-related apoptosis-inducing ligand variant and preparation method and use thereof
WO2016172515A1 (en) 2015-04-23 2016-10-27 Sanford Burnham Prebys Medical Discovery Institute Targeted delivery system and methods of use therefor
WO2016179394A1 (en) 2015-05-05 2016-11-10 Malik Mohammad Tariq Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468758B1 (en) * 1998-09-23 2002-10-22 Corixa Corporation Compositions and methods for ovarian cancer therapy and diagnosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004279837B2 (en) * 2003-10-09 2010-04-01 University Of Louisville Research Foundation, Inc. A method for the treatment of malignant diseases by inhibiting nucleolin

Also Published As

Publication number Publication date
WO2003087124A2 (en) 2003-10-23
AU2003228431A8 (en) 2003-10-27
WO2003087124A3 (en) 2006-08-17

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase