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AU2003227717A1 - 17Alpha-FLUOROALKYL-11Beta-BENZALDOXIME-STEROIDS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAID STEROIDS AND THE USE THEREOF IN THE PRODUCTION OF MEDICAMENTS - Google Patents

17Alpha-FLUOROALKYL-11Beta-BENZALDOXIME-STEROIDS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAID STEROIDS AND THE USE THEREOF IN THE PRODUCTION OF MEDICAMENTS

Info

Publication number
AU2003227717A1
AU2003227717A1 AU2003227717A AU2003227717A AU2003227717A1 AU 2003227717 A1 AU2003227717 A1 AU 2003227717A1 AU 2003227717 A AU2003227717 A AU 2003227717A AU 2003227717 A AU2003227717 A AU 2003227717A AU 2003227717 A1 AU2003227717 A1 AU 2003227717A1
Authority
AU
Australia
Prior art keywords
production
steroids
medicaments
benzaldoxime
11beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003227717A
Inventor
Walter Elger
Gunter Kaufmann
Sven Ring
Birgitt Schneider
Gerd Schubert
Ingo Tornus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10221034A external-priority patent/DE10221034A1/en
Application filed by Schering AG filed Critical Schering AG
Publication of AU2003227717A1 publication Critical patent/AU2003227717A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to compounds of general formula I and the pharmaceutically compatible salts thereof, wherein R1 represents hydrogen, C1- to C6-alkyl, COR4, COOR4, COSR4 or CONHR5, wherein R4 represents C1- to C6-alkyl or unsubstituted or substituted aryl and R5 represents hydrogen, C1- to C6-alkyl or unsubstituted or substituted aryl, additionally R2 represents hydrogen, C1- to C6-alkyl or C1- to C6-acyl and R3 represents a CnF2n+1-group, wherein n = 1, 2 or 3, or represents a CH2O(CH2)mCnF2n+1-group, whereby m = 0 or 1 and n = 1, 2 or 3. The invention also relates to a method for producing said compounds of general formula I. Said compounds can be used in the production of medicaments.
AU2003227717A 2002-05-03 2003-05-05 17Alpha-FLUOROALKYL-11Beta-BENZALDOXIME-STEROIDS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAID STEROIDS AND THE USE THEREOF IN THE PRODUCTION OF MEDICAMENTS Abandoned AU2003227717A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10221034A DE10221034A1 (en) 2002-05-03 2002-05-03 New 17-alpha-fluoroalkyl-11-beta-benzaldoxime-estradiene derivatives, useful as antigestagens in post-menopausal hormone replacement therapy or for treating e.g. gynecological disorders
DE10221034.9 2002-05-03
US44940103P 2003-02-25 2003-02-25
US60/449,401 2003-02-25
PCT/EP2003/004686 WO2003093292A1 (en) 2002-05-03 2003-05-05 17α-FLUOROALKYL-11β-BENZALDOXIME-STEROIDS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAID STEROIDS AND THE USE THEREOF IN THE PRODUCTION OF MEDICAMENTS

Publications (1)

Publication Number Publication Date
AU2003227717A1 true AU2003227717A1 (en) 2003-11-17

Family

ID=29403591

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003227717A Abandoned AU2003227717A1 (en) 2002-05-03 2003-05-05 17Alpha-FLUOROALKYL-11Beta-BENZALDOXIME-STEROIDS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAID STEROIDS AND THE USE THEREOF IN THE PRODUCTION OF MEDICAMENTS

Country Status (8)

Country Link
EP (1) EP1501859B1 (en)
JP (1) JP2005536463A (en)
AT (1) ATE307823T1 (en)
AU (1) AU2003227717A1 (en)
DE (1) DE50301507D1 (en)
DK (1) DK1501859T3 (en)
ES (1) ES2252670T3 (en)
WO (1) WO2003093292A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054535A1 (en) 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesterone receptor antagonist
DE102009034368A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-acyloxyalkylenephenyl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034362A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034366A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-methyleneoxyalkylene aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034367A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene derivatives, process for their preparation and their use for the treatment of diseases
DE102009034525A1 (en) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102010007719A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
DE102010007722A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706061A1 (en) * 1997-02-07 1998-08-13 Schering Ag Anti-gestagen effective steroids with fluorinated 17alpha alkyl chain
DE19745085A1 (en) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11β-Benzaldoxim-9alpha, 10alpha-epoxy-estr-4-ene derivatives, processes for their preparation and pharmaceutical preparations containing these compounds

Also Published As

Publication number Publication date
JP2005536463A (en) 2005-12-02
DE50301507D1 (en) 2005-12-01
WO2003093292A1 (en) 2003-11-13
DK1501859T3 (en) 2006-03-06
ES2252670T3 (en) 2006-05-16
ATE307823T1 (en) 2005-11-15
EP1501859B1 (en) 2005-10-26
EP1501859A1 (en) 2005-02-02

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase