AU2003206329B2 - Use of low molecular weight compounds for preparing a medicament useful in treating mutant P53 mediated diseases - Google Patents
Use of low molecular weight compounds for preparing a medicament useful in treating mutant P53 mediated diseases Download PDFInfo
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- AU2003206329B2 AU2003206329B2 AU2003206329A AU2003206329A AU2003206329B2 AU 2003206329 B2 AU2003206329 B2 AU 2003206329B2 AU 2003206329 A AU2003206329 A AU 2003206329A AU 2003206329 A AU2003206329 A AU 2003206329A AU 2003206329 B2 AU2003206329 B2 AU 2003206329B2
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- mutant
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- mira
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35783102P | 2002-02-21 | 2002-02-21 | |
| SE0200523-9 | 2002-02-21 | ||
| SE0200523A SE0200523D0 (sv) | 2002-02-21 | 2002-02-21 | New compounds |
| US60/357,831 | 2002-02-21 | ||
| PCT/SE2003/000206 WO2003070250A1 (fr) | 2002-02-21 | 2003-02-07 | Utilisation de composes a faible poids moleculaire pour preparer un medicament utilise dans le traitement de maladies mediees par le mutant p53 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003206329A1 AU2003206329A1 (en) | 2003-09-09 |
| AU2003206329B2 true AU2003206329B2 (en) | 2007-08-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003206329A Expired AU2003206329B2 (en) | 2002-02-21 | 2003-02-07 | Use of low molecular weight compounds for preparing a medicament useful in treating mutant P53 mediated diseases |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7659278B2 (fr) |
| EP (1) | EP1476166B1 (fr) |
| AT (1) | ATE333280T1 (fr) |
| AU (1) | AU2003206329B2 (fr) |
| CA (1) | CA2476825C (fr) |
| DE (1) | DE60306896T2 (fr) |
| ES (1) | ES2269975T3 (fr) |
| WO (1) | WO2003070250A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1605939B1 (fr) * | 2003-03-24 | 2008-10-15 | Aprea Ab | Utilisation pharmaceutique de 1-azabicyclo ¬2.2.2 octanes et procede d'essai de composes concernant la capacite d'activation de wt p53 inactif |
| SE0400708D0 (sv) * | 2004-03-22 | 2004-03-22 | Aprea Ab | New compounds and use thereof |
| US7790474B1 (en) | 2005-07-15 | 2010-09-07 | Schering Corporation | p53 modulators |
| ITNA20090047A1 (it) * | 2009-07-16 | 2011-01-17 | Adele Bolognese | Agenti antitumorali con attività inibitoria di proteine di prenilazione, processo di preparazione e impieghi in campo medico |
| WO2011089234A2 (fr) * | 2010-01-21 | 2011-07-28 | Aprea Ab | Procédé et composition |
| CN104860994A (zh) * | 2014-02-20 | 2015-08-26 | 中国药科大学 | 3-奎宁环酮类含磷化合物的制备及其医药用途 |
| EP3762035A4 (fr) * | 2018-03-09 | 2022-03-02 | Texas Tech University System | Compositions et méthodes pour le diagnostic et le traitement du cancer à alt |
| US20210371855A1 (en) * | 2018-06-15 | 2021-12-02 | Ideaya Biosciences, Inc. | Methods of inhibiting proliferative cells |
| CN112771041A (zh) | 2018-09-20 | 2021-05-07 | 阿普里治疗公司 | 奎宁环-3-酮衍生物及其在癌症治疗中的用途 |
| CA3154120A1 (fr) | 2019-09-18 | 2021-03-25 | Aprea Therapeutics Ab | Traitement combine contenant un reactivateur de p53 et un inhibiteur d'une proteine anti-apoptotique de la famille bcl-2 |
| WO2021170772A1 (fr) | 2020-02-26 | 2021-09-02 | Aprea Therapeutics Ab | Traitement combiné contenant un réactivateur de p53 et un inhibiteur de signalisation à médiation de cd47 |
| WO2021180338A1 (fr) | 2020-03-09 | 2021-09-16 | Aprea Therapeutics Ab | Polythérapie avec un réactivateur de p53 et un inhibiteur d'adn méthyltransférase post-greffe de cellules souches |
| WO2022175402A1 (fr) | 2021-02-18 | 2022-08-25 | Aprea Therapeutics Ab | Dérivés de quinuclidine-3-one |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000034276A1 (fr) * | 1998-12-11 | 2000-06-15 | R.J. Reynolds Tobacco Company | Derives a tete de pont pyridyle et leurs analogues, compositions pharmaceutiques et leur utilisation comme inhibiteurs des recepteurs cholinergiques nicotiniques |
| WO2002024692A1 (fr) * | 2000-09-20 | 2002-03-28 | Karolinska Innovations Ab | Derives de 1-azabicyclo(2.2.2)octan-3-one et derives de maleimide et leur utilisation pour traiter des tumeurs cancereuses |
| WO2002078679A2 (fr) * | 2001-03-29 | 2002-10-10 | Topo Target Aps | Derives de succinimide et de maleimide et leur utilisation comme inhibiteurs catalytiques de la topoisomerase ii |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002016356A2 (fr) * | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Composes aryle substitues par quinuclidine destines au traitement de maladies |
-
2003
- 2003-02-07 DE DE60306896T patent/DE60306896T2/de not_active Expired - Lifetime
- 2003-02-07 US US10/505,407 patent/US7659278B2/en not_active Expired - Lifetime
- 2003-02-07 ES ES03703621T patent/ES2269975T3/es not_active Expired - Lifetime
- 2003-02-07 AU AU2003206329A patent/AU2003206329B2/en not_active Expired
- 2003-02-07 EP EP03703621A patent/EP1476166B1/fr not_active Expired - Lifetime
- 2003-02-07 WO PCT/SE2003/000206 patent/WO2003070250A1/fr not_active Ceased
- 2003-02-07 AT AT03703621T patent/ATE333280T1/de active
- 2003-02-07 CA CA2476825A patent/CA2476825C/fr not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000034276A1 (fr) * | 1998-12-11 | 2000-06-15 | R.J. Reynolds Tobacco Company | Derives a tete de pont pyridyle et leurs analogues, compositions pharmaceutiques et leur utilisation comme inhibiteurs des recepteurs cholinergiques nicotiniques |
| WO2002024692A1 (fr) * | 2000-09-20 | 2002-03-28 | Karolinska Innovations Ab | Derives de 1-azabicyclo(2.2.2)octan-3-one et derives de maleimide et leur utilisation pour traiter des tumeurs cancereuses |
| WO2002078679A2 (fr) * | 2001-03-29 | 2002-10-10 | Topo Target Aps | Derives de succinimide et de maleimide et leur utilisation comme inhibiteurs catalytiques de la topoisomerase ii |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003206329A1 (en) | 2003-09-09 |
| WO2003070250A1 (fr) | 2003-08-28 |
| DE60306896D1 (de) | 2006-08-31 |
| EP1476166B1 (fr) | 2006-07-19 |
| DE60306896T2 (de) | 2007-02-15 |
| ES2269975T3 (es) | 2007-04-01 |
| US7659278B2 (en) | 2010-02-09 |
| US20050090510A1 (en) | 2005-04-28 |
| EP1476166A1 (fr) | 2004-11-17 |
| ATE333280T1 (de) | 2006-08-15 |
| CA2476825C (fr) | 2011-04-05 |
| CA2476825A1 (fr) | 2003-08-28 |
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