AU2003201950B2 - A cosmetic product to prevent and correct skin damage - Google Patents
A cosmetic product to prevent and correct skin damage Download PDFInfo
- Publication number
- AU2003201950B2 AU2003201950B2 AU2003201950A AU2003201950A AU2003201950B2 AU 2003201950 B2 AU2003201950 B2 AU 2003201950B2 AU 2003201950 A AU2003201950 A AU 2003201950A AU 2003201950 A AU2003201950 A AU 2003201950A AU 2003201950 B2 AU2003201950 B2 AU 2003201950B2
- Authority
- AU
- Australia
- Prior art keywords
- composition
- acid
- prevent
- correct
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000037380 skin damage Effects 0.000 title claims description 24
- 239000002537 cosmetic Substances 0.000 title claims description 20
- 239000000203 mixture Substances 0.000 claims description 139
- -1 polyethylene Polymers 0.000 claims description 32
- 230000000475 sunscreen effect Effects 0.000 claims description 27
- 239000000516 sunscreening agent Substances 0.000 claims description 27
- 230000005855 radiation Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 13
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 12
- 230000008878 coupling Effects 0.000 claims description 11
- 238000010168 coupling process Methods 0.000 claims description 11
- 238000005859 coupling reaction Methods 0.000 claims description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 11
- 230000006378 damage Effects 0.000 claims description 7
- JKRDADVRIYVCCY-UHFFFAOYSA-N 2-hydroxyoctanoic acid Chemical compound CCCCCCC(O)C(O)=O JKRDADVRIYVCCY-UHFFFAOYSA-N 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-M 4-aminobenzoate Chemical class NC1=CC=C(C([O-])=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-M 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims description 3
- 150000003851 azoles Chemical class 0.000 claims description 3
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000012965 benzophenone Substances 0.000 claims description 3
- 150000008366 benzophenones Chemical class 0.000 claims description 3
- WBYWAXJHAXSJNI-UHFFFAOYSA-N cinnamic acid Chemical class OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 3
- 235000001671 coumarin Nutrition 0.000 claims description 3
- 150000004775 coumarins Chemical class 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 229920002647 polyamide Polymers 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000003873 salicylate salts Chemical class 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 27
- 239000000047 product Substances 0.000 description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- 239000002253 acid Substances 0.000 description 15
- 239000000194 fatty acid Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 239000004166 Lanolin Substances 0.000 description 11
- 235000019388 lanolin Nutrition 0.000 description 11
- 229940039717 lanolin Drugs 0.000 description 11
- 150000004665 fatty acids Chemical class 0.000 description 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 239000003755 preservative agent Substances 0.000 description 10
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 10
- 238000009472 formulation Methods 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 9
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 239000003974 emollient agent Substances 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 8
- 229920001296 polysiloxane Polymers 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 6
- 229940099367 lanolin alcohols Drugs 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 5
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- 238000012937 correction Methods 0.000 description 5
- 229940086555 cyclomethicone Drugs 0.000 description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 description 5
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 5
- 150000002191 fatty alcohols Chemical class 0.000 description 5
- 229960004275 glycolic acid Drugs 0.000 description 5
- 239000003906 humectant Substances 0.000 description 5
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 5
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 5
- 229960002216 methylparaben Drugs 0.000 description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 5
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 5
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 5
- 229960003415 propylparaben Drugs 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 235000021355 Stearic acid Nutrition 0.000 description 4
- OFUHPGMOWVHNPN-QWZFGMNQSA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] (9z,12z)-octadeca-9,12-dienoate Chemical compound O1[C@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CCC2=C(C)C(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)=C(C)C(C)=C21 OFUHPGMOWVHNPN-QWZFGMNQSA-N 0.000 description 4
- 239000002518 antifoaming agent Substances 0.000 description 4
- 235000013871 bee wax Nutrition 0.000 description 4
- 239000012166 beeswax Substances 0.000 description 4
- 229940092738 beeswax Drugs 0.000 description 4
- 229960000541 cetyl alcohol Drugs 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 4
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 4
- 229940108325 retinyl palmitate Drugs 0.000 description 4
- 235000019172 retinyl palmitate Nutrition 0.000 description 4
- 239000011769 retinyl palmitate Substances 0.000 description 4
- 239000008117 stearic acid Substances 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- 239000011787 zinc oxide Substances 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical class CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 3
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 3
- 229920002873 Polyethylenimine Polymers 0.000 description 3
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 3
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical group CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229960001679 octinoxate Drugs 0.000 description 3
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- PTPDZZWUOHQSLG-UHFFFAOYSA-N 2-octyldodecyl 2,2-dimethylpropanoate Chemical compound CCCCCCCCCCC(COC(=O)C(C)(C)C)CCCCCCCC PTPDZZWUOHQSLG-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical compound CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004283 Sodium sorbate Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000005907 alkyl ester group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229940100463 hexyl laurate Drugs 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 229940048862 octyldodecyl neopentanoate Drugs 0.000 description 2
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 2
- 229960001173 oxybenzone Drugs 0.000 description 2
- SSZBUIDZHHWXNJ-UHFFFAOYSA-N palmityl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 2
- 229940066675 ricinoleate Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 2
- 229960001860 salicylate Drugs 0.000 description 2
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 2
- 235000019250 sodium sorbate Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940057429 sorbitan isostearate Drugs 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- 238000004078 waterproofing Methods 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- PDHSAQOQVUXZGQ-JKSUJKDBSA-N (2r,3s)-2-(3,4-dihydroxyphenyl)-3-methoxy-3,4-dihydro-2h-chromene-5,7-diol Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2OC)=CC=C(O)C(O)=C1 PDHSAQOQVUXZGQ-JKSUJKDBSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-KRWDZBQOSA-N (S)-2-hydroxyoctadecanoic acid Chemical compound CCCCCCCCCCCCCCCC[C@H](O)C(O)=O KIHBGTRZFAVZRV-KRWDZBQOSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- JQJSFAJISYZPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(2,3-dihydro-1h-inden-5-ylsulfonyl)urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NS(=O)(=O)C1=CC=C(CCC2)C2=C1 JQJSFAJISYZPER-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- RMFFCSRJWUBPBJ-UHFFFAOYSA-N 15-hydroxypentadecyl benzoate Chemical compound OCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1 RMFFCSRJWUBPBJ-UHFFFAOYSA-N 0.000 description 1
- JSOVGYMVTPPEND-UHFFFAOYSA-N 16-methylheptadecyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C(C)(C)C JSOVGYMVTPPEND-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- WHQOKFZWSDOTQP-UHFFFAOYSA-N 2,3-dihydroxypropyl 4-aminobenzoate Chemical compound NC1=CC=C(C(=O)OCC(O)CO)C=C1 WHQOKFZWSDOTQP-UHFFFAOYSA-N 0.000 description 1
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical class CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 1
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- DWYHDSLIWMUSOO-UHFFFAOYSA-N 2-phenyl-1h-benzimidazole Chemical compound C1=CC=CC=C1C1=NC2=CC=CC=C2N1 DWYHDSLIWMUSOO-UHFFFAOYSA-N 0.000 description 1
- HMKKFLSUPRUBOO-IUPFWZBJSA-N 3,4-dihydroxy-5-[3,4,5-tris[[(z)-octadec-9-enoyl]oxy]benzoyl]oxybenzoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1=C(OC(=O)CCCCCCC\C=C/CCCCCCCC)C(OC(=O)CCCCCCC\C=C/CCCCCCCC)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(O)=O)O)=C1 HMKKFLSUPRUBOO-IUPFWZBJSA-N 0.000 description 1
- NZXZINXFUSKTPH-UHFFFAOYSA-N 4-[4-(4-butylcyclohexyl)cyclohexyl]-1,2-difluorobenzene Chemical compound C1CC(CCCC)CCC1C1CCC(C=2C=C(F)C(F)=CC=2)CC1 NZXZINXFUSKTPH-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- IBYCEACZVUOBIV-UHFFFAOYSA-N 4-methylpentyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCC(C)C IBYCEACZVUOBIV-UHFFFAOYSA-N 0.000 description 1
- AUGIYYGVQDZOLU-UHFFFAOYSA-N 4-methylpentyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCC(C)C AUGIYYGVQDZOLU-UHFFFAOYSA-N 0.000 description 1
- ODMZDMMTKHXXKA-QXMHVHEDSA-N 8-methylnonyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCCCCCC(C)C ODMZDMMTKHXXKA-QXMHVHEDSA-N 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 244000180278 Copernicia prunifera Species 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000004164 Wax ester Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229940048299 acetylated lanolin alcohols Drugs 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 229920013820 alkyl cellulose Polymers 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 description 1
- 229960005193 avobenzone Drugs 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- UBKBVPONTPMQQW-UHFFFAOYSA-N azane;2-hydroxyacetic acid Chemical compound [NH4+].OCC([O-])=O UBKBVPONTPMQQW-UHFFFAOYSA-N 0.000 description 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- PPOZILIWLOFYOG-UHFFFAOYSA-N bis(2-hexyldecyl) hexanedioate Chemical compound CCCCCCCCC(CCCCCC)COC(=O)CCCCC(=O)OCC(CCCCCC)CCCCCCCC PPOZILIWLOFYOG-UHFFFAOYSA-N 0.000 description 1
- IUGNTDSUZLPSOK-UHFFFAOYSA-N bis(4-methylpentyl) hexanedioate Chemical compound CC(C)CCCOC(=O)CCCCC(=O)OCCCC(C)C IUGNTDSUZLPSOK-UHFFFAOYSA-N 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 229940114081 cinnamate Drugs 0.000 description 1
- CMDKPGRTAQVGFQ-RMKNXTFCSA-N cinoxate Chemical compound CCOCCOC(=O)\C=C\C1=CC=C(OC)C=C1 CMDKPGRTAQVGFQ-RMKNXTFCSA-N 0.000 description 1
- 229960001063 cinoxate Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000012716 cod liver oil Nutrition 0.000 description 1
- 239000003026 cod liver oil Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- UKPBEPCQTDRZSE-UHFFFAOYSA-N cyclizine hydrochloride Chemical compound Cl.C1CN(C)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 UKPBEPCQTDRZSE-UHFFFAOYSA-N 0.000 description 1
- KBODESQIOVVMAI-UHFFFAOYSA-N decyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCC KBODESQIOVVMAI-UHFFFAOYSA-N 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940099371 diacetylated monoglycerides Drugs 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 1
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical class CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- UONUEPNDJQOXAG-UHFFFAOYSA-N ethyl 4-[bis(3-hydroxypropyl)amino]benzoate Chemical compound CCOC(=O)C1=CC=C(N(CCCO)CCCO)C=C1 UONUEPNDJQOXAG-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- FIJYTZBJXJCZQO-UHFFFAOYSA-N hexyl dodecanoate;propan-2-yl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C.CCCCCCCCCCCC(=O)OCCCCCC FIJYTZBJXJCZQO-UHFFFAOYSA-N 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940093629 isopropyl isostearate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229940049918 linoleate Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- VAMFXQBUQXONLZ-UHFFFAOYSA-N n-alpha-eicosene Natural products CCCCCCCCCCCCCCCCCCC=C VAMFXQBUQXONLZ-UHFFFAOYSA-N 0.000 description 1
- GQEZCXVZFLOKMC-UHFFFAOYSA-N n-alpha-hexadecene Natural products CCCCCCCCCCCCCCC=C GQEZCXVZFLOKMC-UHFFFAOYSA-N 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- 229960000601 octocrylene Drugs 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- LXTZRIBXKVRLOA-UHFFFAOYSA-N padimate a Chemical compound CCCCCOC(=O)C1=CC=C(N(C)C)C=C1 LXTZRIBXKVRLOA-UHFFFAOYSA-N 0.000 description 1
- 229960002824 padimate a Drugs 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
Our Ref:7779791 P/00/011I Regulation 3:2
AUSTRALIA
Patents Act 1990
ORIGINAL
COMPLETE SPECIFICATION STANDARD PATENT Applicant(s): Address for Service: Invention Title: Unilever PLC Unilever House Blackfriars London EC4P 4BQ United Kingdom DAVIES COLLISON CAVE Patent Trade Mark Attorneys Level 10, 10 Barrack Street SYDNEY NSW 2000 A cosmetic product to prevent and correct skin damage The following statement is a full description of this invention, including the best method of performing it known to me:- 5020 1 A COSMETIC PRODUCT TO PREVENT AND CORRECT SKIN DAMAGE BACKGROUND OF THE INVENTION Field of the Invention The invention concerns a cosmetic product formed with separate containers storing skin damage prevention and correction compositions.
^O The Related Art Dual .purpose single formulation cosmetic products are quite handy and popular. Examples of 2-in-l commercial formulations are cleanser moisturizer and shampoo conditioner products. Unfortunately, single formulations often compromise the performance of the severally combined actives.
A response to this problem has been the development of skin treatment regimes. Two or more different cosmetic compositions are employed in these regimes and applied to the skin in sequential order. Illustrative commercial treatment regime compositions are cleansers, moisturizers, toners and facial foundations.
Multi-compartmented containers for dispensing a.o.t.
toiletries and medicaments have been-described in NL-A-9 301 506 and CH-A-585 647. These containers have been suggested as useful for -travel and to improve the aesthetics of a dressing table.
The present invention has sought a system to deliver actives for prevention of skin damage and also to correct damage. Herein it is suggested that separate compositions in a treatment regime be formulated for skin damage la prevention and for correction. Each of these compositions would then. require respective timing for application to skin. Prevention compositions are suggested for daytime use utilizing sunscreens as the active- Correction compositions would be for nighttime use. They should incorporate an a-hydroxycarboxylic acid as the active.
o 0 would be for nighttime use. They should incorporate an ahydroxycarboxylic acid as the active. Relatively-high levels of the g-hydtoxycarboxylic acids must be present in the correction composition. By contrast, little or none of this substance is necessary for the prevention composition during daytime use in the sun.
When a skin treatment regime requires multi-composition use, there have been problems with consumer education and 3 discipline. Education is particularly a problem in mass market outlets where a cosmetic knowledgeable sales staff is generally absent. A customer may purchase one product in a treatment regime but may be uninformed with respect to a necessary complementary regime product. Even a somewhat educated customer may select the wrong complementary product. Most frustrating is when a totally educated customer discovers that the store either does not carry the complementary product or is temporarily out of stock.
Even when a customer has been educated and supplied with proper products, the products may become separated at home.
Moreover, the necessary reinforcement of use according to a o regime may no longer be present.
Accordingly, it is an object of the present invention to provide a cosmetic product for a skin treatment regime that assists the consumer in maintaining the regime.
It is another object of the present invention to provide a cosmetic product with multi-compositions for a skin treatment regime that ensures the recommended compositions are all provided to the consumer in a single sale.
Still another object of the present invention is to provide a cosmetic product for a skin treatment regime that daily 3 serves as a reminder to the consumer as to the proper utilization of component compositions..
Yet another object of the present invention is to provide a cosmetic product for a skin treatment regime that maintains each of the compositions together in a unit to avoid separation and misplacement within a consumer's home.
SUMMARY OF THE INVENTION 1 A cosmetic product to prevent and correct skin damage is provided including: a first composition having a sunscreen present in an effective amount to prevent UV radiation from penetrating the composition to reach a user's skin; a second composition having a C 2
-C,
0 a-hydroxycarboxylic acid or salt thereof present in an effective amount to correct UV radiation induced skin damage;a first container for storing the first composition; and a second container for storing the second composition, the first and second containers being releasably joined together.
Preferably the first and second containers are each fitted with a mechanism for coupling the two Logether, with a preferable coupling being a screw thread arrangement.
Advantageously the first and second containers are jars stacked one above the other and releasably locked together through the coupling mechanism.
Also provided is a method to prevent and correct skin damage, the method including the steps of: providing a first composition having a sunscreen present in an effect amount to prevent UV radiation from penetrating the composition to reach a user's skin: providing a second composition having a C 2 -C3 0
D-
hydroxycarboxylic acid or salt thereof present in an effective amount to correct UV radiation induced skin damage; storing the first composition in a first container; storing the secnhd-composition in a second container, the first and second containers being releasably joined together; applying the first composition to the skin so as to remain in contact during daytime and to prevent UV radiation induced skin damage; and applying the second composition after application of the first composition so as to remain in contact over night on the skin to correct for any UV radiation damace.
As now claimed, according to one aspect, the present invention provides cosmetic method to prevent and correct skin damage, in which method is used a first composition having a sunscreen present in an effective amount to prevent UV radiation from penetrating the composition to reach a suer's skin, and a second composition having a C 2
-C
30 ahydroxycarboxylic acid or salt thereof present in an effective amount to correct UV radiation induced skin damage; which first composition is stored in a first container and which second composition is stored in a second container, the first and second containers fitted with a means for coupling same to one another; which method comprises applying the first composition to the skin so as to remain in contact during daytime and to prevent UV radiation induced skin damage; and applying the second composition after application of the first composition so as 3 to remain in contact overnight on the skin to correct for any UV radiation damage.
As now claimed, according to another aspect, the present invention provides the use of a product in the manufacture of a medicament to prevent and correct skin damage, which product includes a first composition having a sunscreen present in an effective amount to prevent UV radiation from penetrating the composition to reach a user's skin, and a second composition having a C 2
-C
30 c-hydroxycarboxylic acid or salt thereof present in an effective amount to correct UV radiation induced skin damage; which first composition is stored in a first container and which second composition is stored in a second container, the first and second containers fitted with a means for coupling same to one another; wherein the first composition is applied to the skin so as to remain in contact during daytime and to prevent UV radiation induced skin damage; and wherein the second composition is applied after application of the first composition so as to remain in contact overnight on the skin to correct for any UV radiation damage.
BRIEF DESCRIPTION OF THE DRAWING The above features, advantages and objects of the present invention will more fully be appreciated through the following detailed discussion, reference being made-to the sole Figure shbwing an exploded view of a stacked first and second container screwably and releasably joinable together.
DETAILED DESCRIPTION Now it has been found that a day and night skin treatment regime with respective damage prevention and correction compositions can be sold to a consumer as a unit, serve as a reminder for joint usage and also educate a customer in proper application thereof. These advantages are achieved through disposition and sale of the respective compositions in respective containers wherein the two containers are 4b joined together. Most preferably, joinder is achieved through a stacking arrangement of the containers as respective jars releasably lockable one on top another.
The Figure illustrates the dispensing package as including a first container or jar 2, a second container or jar 4 and a domed cap 6. First container 2 is fitted at an open end 5 thereof with a threaded male screw 8 that can lockingly engage cap 6 for closure of that jar. A first composition incorporating a sunscreen for use as a damage prevention formulation during daytime wear is stored within container 2.
Second container 4 at an open end thereof is also fitted with a threaded male screw 10. A second composition incorporating an a-hydroxycarboxylic acid or salt thereof is stored within this second container. Threaded male screw 10 is lockingly joinable with a threaded female screw 12 arranged below a closed bottom end 14 of the first container 2. In a preferred embodiment, the first container 2 storing the prevention composition has an outer color different from that of the outer color of the second container 4. Most preferred is that the first container 2 be colored predominantly white (day formula) and the second container 4 be colored predominantly black (night formula) The term "predominantly" means greater than 50% of the surface area of outer walls of the container. Color coding provides the consumer with an educational signal for proper use of the cosmetic product.
Beyond the package, a first essential element of cosmetic products according to the present invention is that of a first composition incorporation a sunscreen. The term "sunscreen" is used to denote ultraviolet ray-blocking compounds inhibiting absorption within the wavelength region between 290 and 420 nm. These compounds may either be organic or inorganic. The organic compounds are preferred. When the sunscreen is inorganic and serves as the sole sun protective substance, it should be present at levels ranging from 5 to 30%, preferably from 8 to 15% by weight.
Typical inorganic sunscreens include titanium dioxide, zinc oxide, iron oxide and combinations thereof. Most preferred is titanium dioxide, especially having an average particle Typical inorganic sunscreens include titanium dioxide, zinc oxide, iron oxide and combinations thereof. Most preferred is titanium diokider-especially having an average particle size no higher than 700 nm, preferably no higher than 200 nm, optimally less than 35 nm.
Organic sunscreens suitable for the present invention may be classified into five groups based upon their chemical structures: para-amino benzoates; salicylates; cinnamates; benzophenones; coumarins; azoles and miscellaneous chemicals including menthyl anthralinate. Also polymeric particles may be useful such as polyethylene and polyamides. Among FDA-approved sunscreens are those listed in the Table below.
0 mmnna=..- jIN-A Absorbers- rz Li I oxybenzole1 also known as 2-hydroxy- 4-inethoxy benzophelOle and benzophelofe-3, available as Uvinul M4-40 and Cafsorb 21141 2-6 Butyl HethOxydibeflZOYlmethane
N/A.
available as Parsol 1789 niaxybenzone, also known as 2,2 dihydroxy- 4-inethoxy beozopheloe, and benzophelOfle-8 3 SulibenzOle, also known as 2-hydroxy- 4-methoxy benzophelOfle-SSUlPholiC acid, and benzophenOle- 4 available as Uvinul and Gafsorb 2H4MS 5-10 Menthyl anthraliflate, also known as menthyl-o-amilobeflzoate 3.5-5 TlY-B Asorbers AbprQ3Ld 0 p-Amino benzoic acid, also known as PABA 5-15 Amyl dimethyl PABA also known as amyl-p-dimethyl ammonium benzoate, available as Padimate A 2-Ethoxy ethyl p-methoxy cinnawate
(NA),
available as Cinoxate and Givtan-F 1-3 Diethaflolamifle p-ethoxy cinnamate, also known as DEA rnethoxy cinnatnate, available as Parsol-Hydro 8-10 Digalloyl trioleate a component of Soiprocex 1 Ethyl-4-bis (hydroxypropyl) aminobenzoate, also known as eth yl dihydroxy propyl PABA available as Amerscreen P 2-Ethyl hexyl--2-CYalO-31 3 diphenyl acrylate, also kn own as octocrylene and available as Uvinul N-5 39 7-10 Q Ethyl hexyl p-methoxy cinnamate, also known as octyl rnethoxycinnfartate available as Parsol MCX 2-7.59 2-Ethyl hexyl salicylate, also known as octyl salicylate Glyceryl aminobenzoate. also known as glyceryl p-aminobenzoate and glyceryl.PABA,' available as Escal~l 106 2-3 Homomenthyl salicylate, also known as 3, 3.5-trimethylcyclohexcyl salicylate 4-15 0 25 Lawsome with dihydroxyaCetole.(NA) 0.25 with 33 Octyl dimethyl PABA, also known as 2-ethyl hexyl p-dimethyl p-aminobenzoate and 2-ethyl hexyl dimethyl PABA, ava-ilable 3 r as Padirnate 0 and Escalol 507 1.4-8 2-Phenyl benzimidazOle 5-sulphoic acid 1.4 Triethanolamile salicylate 5-12 organic sunscreen compound will range in ant amount anywhere from 0.1 to 25%, optimally from 1 t-o 15%, most -9 preferably from 5 to 10% by weight.
Another essential element of cosmetic products according to the present invention is that of a second composition which incorporates a C 2
-C
30 a-hydroxycarboxylic acid or salt thereof. A wide variety of a-hydroxycarboxylic acids may be employed, suitable examples of which include: a-hydroxyethanoic acid a-hydroxypropanoic acid a-hydroxyhexanoic acid Q ta-hydroxyoctanoic acid a-hydroxydecanoic acid a-hydroxydodecanoic acid a-hydroxytetradecanoic acid a-hydroxyhexadecanoic acid a-hydroxyoctadecanoic acid a-hydroxyeicosanoic acid a-hydroxydocosanoic acid a-hydroxyhexacosanoic acid, and a-hydroxyoctacosanoic acid Particularly preferred from the above list are ahydroxyethanoic acid (commonly known as glycolic acid), a- 0 25 hydroxypropanoic acid (commonly known as lactic acid) and a-hydroxyoctanoic acid (commonly known as a-hydroxycaprylic acid or HCA).
For purposes of this invention, the term ahydroxycarboxylic acids are intended to include not only the acid form but also salts thereof. Typical salts are the alkalimetal, ammonium and Co 2 -Co ammonium salts thereof. Particularly preferred are the sodium, potassium, triethanolammonium, polyethyleneimine and ammonium salts.
Combinations of all the foregoing may be present in the compositions. Amounts of the a-hydroxycarboxylic acid or salt thereof may range from 0.01 to 10 preferably from 0.1 to 12%, optimally from 0.5 to 9% by weight.
Either or botl of-the first and second compositions of the present invention may be solid or liquid, aqueous or anhydrous and opaque or transparent.
A pharmaceutically acceptable carrier is ordinarily utilised to deliver the sunscreen and the ahydroxycarboxylic acid active components of the first and second compositions. Most preferably, cosmetic compositions of this invention will be in emulsion form.
By definition, an emulsion is a dispersed system containing at least two immiscible liquid phases, one of which is dispersed in the form of small droplets throughout the other. Water and oil are the most common immiscible phases. An emulsion in which oil is dispersed as droplets throughout the aqueous phase is termed an oil-in-water emulsion. When water is the dispersed phase and an oil is the dispersion medium, a water-in-oil emulsion exists.
Contemplated within the scope of this invention are emulsions in the form of lotions and creams of both types of emulsion, those where the water phase is continuous and those where the oil phase is continuous. The amount of these phases may range from 99:1 to 1:99 by weight.
The term "pharmaceutically acceptable carrier" according to this invention includes emollients, surfactants, humectants and water. Total amount of the carrier may range from to 99.9%, preferably from 50 to 90%, optimally from 70 to by weight.
A variety of oily emollients may be employed in the compositions of this invention. These emollients may be selected from one or more of the following classes: 1. Hydrocarbon oils and waxes. Examples thereof are A variety of oily emollients may be employed in the compositions of this invention. These emollients-may be selected from one 'r more of the following classes: 1. Hydrocarbon oils and waxes. Examples thereof are mineral oil, petrolatum, paraffin, ceresin, ozokerite, microcrystalline wax, polyethylene, and perhydrosqualene.
2. Triglyceride esters such as vegetable and animal fats Kand oils. Examples include castor oil, cocoa butter, safflower oil, cottonseed oil, corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil, squalene, and soybean oil.
3. Acetoglyceride esters, such as acetylated monoglycerides.
4. Ethoxylated glycerides, such as ethoxylated glyceryl monostearate.
Alkyl esters of fatty acids having 10 to 22 carbon atoms. Methyl, isopropyl, and butyl esters of fatty acids 0 are useful herein. Examples include hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, di.isopropyl adipate, diisohexyl adipate, dihexyldecyl adipate, diisopropyl sebacate, lauryl lactate, myristyl lactate, and cetyl lactate.
6. Alkenyl esters of fatty acids having 10 to 22 carbon atoms. Examples thereof include oleyl myristate, oleyl stearate, and oleyl oleate.
7. Fatty acids having 10 to 22 carbon atoms. Suitable examples include pelargonic, lauric, myristic, palmitic, stearic, isostearic',hydroxystearic, oleic, linoleic, ricinoleic, arachidic, behenic, and erucic acids.
8. Fatty alcohols having 10 to 22 carbon atoms. Lauryl, myristyl, cetyl, hexadecyl, stearyl, isostearyl, hydroxystearyl, oleyl, ricinoleyl, behenyl, erucyl, and 2-octyl dodecanyl alcohols are examples of satisfactory fatty alcohols.
9. Fatty alcohol ethers. Ethoxylated fatty alcohols of to 22 carbon atoms including the lauryl, cetyl, stearyl, isostearyl, oleyl, and cholesterol alcohols, having attached thereto from 1 to 50 ethylene oxide groups or 1 to propylene oxide groups.
Ether-esters such as fatty acid esters of ethoxylated fatty alcohols.
11. Lanolin and derivatives. Lanolin, lanolin oil, lanolin wax, lanolin alcohols, lanolin fatty acids, isopropyl lanolate, ethoxylated lanolin, ethoxylated lanolin alcohols, ethoxylated cholesterol, propoxylated lanolin alcohols, acetylated lanolin alcohols, lanolin alcohols linoleate, lanolin alcohols ricinoleate, acetate of lanolin alcohols ricinoleate, acetate of ethoxylated alcohols-esters, hydrogenolysis of lanolin, ethoxylated hydrogenated lanolin, ethoxylated sorbitol lanolin, and liquid and semisolid lanolin absorption bases are illustrative of emollients derived from lanolin.
12. Polyhydric alcohol esters. Ethylene glycol mono and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and 13 13. Wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate.
14. Beeswax'derivatives, e.g. polyoxyethylene sorbitol beeswax. These are reaction products of beeswax with ethoxylated sorbitol of varying ethylene oxide content, forming a mixture of ether esters.
Vegetable waxes including carnauba and candelilla waxes.
0 16. Phospholipids such as lecithin and derivatives.
17. Sterols. Cholesterol, cholesterol fatty acid esters are examples thereof.
18. Amides such as fatty acid amides, ethoxylated fatty acid amides, solid fatty acid alkanolamides- Amounts of the above listed emollients may range anywhere from 0.5 to 80% by weight of the total composition.
Preferably the amounts of these emollients will range from 1 to 25%, optimally between 5 and 15% by weight.
Humectants of the polyhydric alcohol-type may also be included in the compositions of this invention. The humectant aids in increasing the effectiveness of the emollient, reduces scaling, stimulates removal of built-up scale and improves skin feel. Typical polyhydric alcohols include polyalkylene glycols and more preferably alkylene polyols and their derivatives, including propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof. For best results the 14 humectant is preferably glycerol. The amount of humectant may range anywhere from 0.1 to 40%, preferably between 1 and 15% by weight of the composition.
For improved lubricity, there may also be included one or more silicone oils or fluids which may be selected from a dimethyl polysiloxane, a nethylphenyl polysiloxane and an alcohol-soluble silicone glycol copolymer. Preferred siloxanes include dimethyl polysiloxane (CTFA name: dimethicone), a polysiloxane end-blocked with trimethyl units and polydimethylcyclosiloxane, (CTFA name: C) cyclomethicone). The preferred siloxanes exhibit a viscosity from 2 to 50-. centistokes at 25 0 C. Amounts of the silicones can range from 0.1 to 80% by weight of the compositions, preferably from 1 to 20% by weight.
Surfactants can also be included in the compositions of this invention. These may be selected from .nonionic, anionic, cationic or amphoteric emulsifying agents. They may range in amount anywhere from 0.1 to 30% by weight.
Illustrative of the nonionic surfactants are alkoxylated compounds based upon fatty alcohols,
C
3 fatty acids and sorbitan. Particularly preferred is Tween an ethoxylated sorbitan (CTFA name: POE sorbitan monooleate), and Myrj 59® which is a polyethoxylated
C,,
fatty acid (CTFA name: POE (100) stearate). A preferred non-ethoxylated nonionic surfactant is Arlacel 60®, (CTFA name: sorbitan monostearate).
Both first and second compositions of the invention can also include thickeners/yiscosifiers in amounts from 0.01 to 10% by weight of the composition. As known to those skilled in the art, the precise amount of thickeners can vary depending upon the consistency and thickness of the composition which is desired. Exemplary thickeners are magnesium aluminum silicate (Veegunm), guar 15 gums (such as Jaguar HP-120®), xanthan gum, sodium carboxymethyl cellulose, hydroxyalkyl and alkyl celluloses, and cross-linked acrylic acid polymers such as those sold by B.F. Goodrich under the Carbopol® trademark.
Waterproofing agents may be included along with the sunscreen containing compositions of this invention. These agents may range in amount anywhere from 0.5 to 10% by weight. Common waterproofing agents are polymers and copolymers based on PVP and acrylic or methacrylic esters.
Specific examples are PVP/Hexadecene Copolymer (Ganex V- O 216®), PVP/Eicosene Copolymer (Ganex V-220®), FpVP/Ethyl Methacrylate/Methacrylic Acid Copolymer, Ammonium Acrylates Copolymer, and Polyolprepolymer-2 (ex Penederm/Barnet) Preservatives can desirably be incorporated into both the first and second compositions of this invention to protect: against the growth of potentially harmful microorganism.
While it is in the aqueous phase that microorganisms tend to grow, microorganisms can also reside in the oil phase.
As such, preservatives which have solubility in both water and oil are preferably employed in the present compositions- Suitable traditional preservatives for compositions of this invention are alkyl esters of parahydroxybenzoic acid. Other preservatives which have more recently come into use include hydantoin derivatives, propionate salts, and a variety of quaternary ammonium compounds. Cosmetic chemists are familiar with appropriate preservatives and routinely choose them to satisfy the preservative challenge test and to provide product stability. Particularly preferred preservatives are methyl paraben, imidazolidinyl urea, sodium dehydroxyacetate, propyl paraben and benzyl alcohol. The preservatives should be selected having regard for the use of the composition and-possible incompatibilities between the preservatives and other ingredients in the emulsion.
Preservatives are preferably employed in amounts ranging 16 from 0.01% to 2% by weight of the composition.
When present, the amount of water in a composition may range anywhere from 1 to 99%, preferably from 20 to optimally between 40 and 70% by weight.
Minor adjunct ingredients'may also include fragrances, antifoam agents, herbal extracts, opacifiers and colorants, each in their effective amounts to accomplish their respective functions.
O Vitamins may also be included in the compositions of the present invention. Especially preferred is Vitamin A palmitate (retinyl palmitate) and Vitamin E linoleate (tocopheryl linoleate). Other esters of Vitamins A and E may also be utilized.
In a preferred aspect of the present invention, the first and second compositions will each have at least' ten components in common. Moreover, the ten components will be present at essentially identical concentrations in both the first and second compositions.
The following examples will more full illustrate the Q 25 composition embodiments of this invention. All parts, percentages and proportions referred to herein and in the appended claims are by weight unless otherwise indicated.
EXAMPLE 1 A pair of prevent and correct compositions were prepared according to the following formulations.
present at essentially identical concentrations in both the first and second compositions.
The following examples will more fully illustrate the composition embodiments of this invention. All parts, percentages and proportions referred to herein and in the appended claims are by weight unless otherwise indicated.
EXAMPLE 1 S A pair of prevent and correct compositions were prepared according to the following formulations.
0 0 TABLE I PREVENT COMPOSITION COMPONENT WEIGHT Parsol MCX® 4.00 Stearic Acid 3.00 Finsolv TN@ 3.00 Butylene Glycol 2.00 Glycerin 2.00 MYRJ 59® 2.00 Uvinul M-40® 2.00 Crodamol ISNP® 2.00 Glycerol Monostearate 1.50 Stearyl Alcohol 1.50 Glycolic Acid 1.40 Triethanolamine 1.20 Lactic Acid 1.15 Magnesium Aluminum 1.00 Silicate Arlacel 60@ 1.00 Silicone 1401® 0.80 Disodium EDTA 0.50 Jaguar HP-120® 0.50 Cholesterol 0.30 Ammonia (Aqueous 26BE) 0.30 Fragrance 0.30 Tween 80® 0.30 Polyethyleneimine 0.25 Methylparaben 0.15 Vitamin E Acetate 0.10 Propylparaben 0.10 Hydroxycaprylic Acid 0.10 Vitamin A Palmitate 0.10 Water qs
Q
TABLE II CORRECT COMPOSITION 0 0 COMPONENT WEIGHT Glycolic Acid 5.74 Butylene Glycol 3.00 Hetester® FAO/Fine 3.00 Stearic Acid 3.00 Finsolv TN® 2.50 Ceraphyl 230® 2.50 Ammonia (Aqueous 26BE) 2.20 Glycerin 2.00 .Myrj 59® 2.00 Polyethylene Imine 2.00 Stearyl Alcohol 1.50 Glycerl Monostearate 1.50 Triethanolamine 1.20 Magnesium Aluminum 1.00 Silicate SE 700 1.00 Silicone Fluid 10 1.00 Arlacel 60® 1.00 Dow Corning 1401® 0.80 Jaguar HP-120® 0.50 Disodium EDTA 0.50 Sodium Sctearoyl 0.50 Lactylate Cholesterol 0.30 Fragrance 0.30 Tween 80® 0.30 Methylparaben 0.15 Antifoam Emulsion 0.10 Vitamin E Acetate 0.10 Propylparaben 0.10 Hydroxycapry1ic Acid 0.10 Vitamin A Palmitate 0.10 Bisabolol 0.10 Water qs 0II 0 EXAMPLE 2 The Prevent and Correct dual composition product was tested for consumer acceptability in a shaved leg sting evaluation with a consumer panel. Formulations tested were identical to that described in Example 1, except for the changes in a-hydroxycarboxylic acid concentrations as noted below.
TABLE IIU COMPOSITION WEIGHT Prevent 1% glycolic, 1% lactic, sunscreen (SPF 8) Correct 4% glycolic (no sunscreen) Prevent/Correct 5% glycolic, 1% (All-in-One lactic, sunscreen Composition) (SPF 8) An expert panel of subjects were selected for the test, each being qualified and proven to show sensitivity to product differences. Subjects were provided with two charged syringes, each filled with 2 cc of sample composition and clearly labelled with left/right designations. Subjects shaved their legs in their shower using a wet razor and applied sample composition immediately upon drying off. They took note of sting sensations and filled out a standard questionnaire.
Results of the test are recorded below.
RESULTS
0 Prevent vs. Alln Magnitude of All-in- Prevent Stinging (mean) Pone 0.79 p 0.05* (0 none, 10 2.54 severe)____ (71% reduction) Duration of Sting All-in-on Prevent None 8 subjects 1 7 subjects subjects minute 9 subjects 8 1 subjects minute 1 subject Which is worse? All-in-One 14 subjects No difference 8 subjects Prevent 1 subject Correct vs. Allin-one n Aii-in- correct One 1.15 P 2.43 0.05* (52% reduction)_____ Duration of Sting All-in-one corrsat None 6 subjects 1 12 subjects minute subjects 11 1 8 subjects subjects minute subjects Which is worse? All-in-One 13 subjects No 11 subjects difference 2 subjects Correct 0 paired t-test Sequential usage of the Prevent and Correct compositions delivered a daily dose of 6% £-hydroxycarboxylic acid with sunscreen levef to provide SPF 8. The comparison product where the Prevent and Correct formulations were combined into a single "all-in-one" composition also contained 6% ahydroxycarboxylic acid with sunscreen level to provide SPF 8.
The clinical study demonstrated that use of the separate 0 Prevent and Correct compositions phased-in the delivery of a-hydroxycarboxylic acid thereby reducing the sting/consumer discomfort that arises when both formulas are blended together as a combined single composition.
Sting reduction of 71% and 52% were obtained, respectively in comparison of the Prevent and Correct compositions against the combination all-in-one product.
EXAMPLE 3 Another pair of prevent and correct compositions illustrative of the present invention are outlined below.
0 The prevent composition will have an SPF of at least 21.
TABLE IV PREVENT COMPOSITION COMPONENT WEIGHT t Propylene Glycol Isoceteth-3 14.00 Acetate Octyl Dodecyl neopentanoate 14.00 Titanium Dioxide (80 micron) 13.00 Parsol MCX® 5.00 Parsol 1789® 4.00 Cetyl Alcohol 4.00 Zinc Oxide 3.00 Dimethicone Copolyol Phosphate 3.00 Sorbitan Isostearate 2.00 Isostearic Acid 1.75 Polyoxyethylene (21) Stearyl Ether 1.50 Magnesium Aluminum Silicate 0.70 Propylene Glycol 0.50 Glycerin 0.50 Triethanolamine 0.35 Xanthan Gum 0.20 Polyoxyethylene Stearyl Ether 0.20 Glydant Plus* 0.20 Fragrance 0.20 Botanical Blend 0.10 Vitamin E Linoleate 0.10 Aloe Vera Gel 0.01 Water qs 0 26 100 TABLE V CORRECT COMPOSITION COMPONENT WEIGHT Propylene Glycol Isoceteth-3 14.00 Acetate Octyl Dodecyl neopentanoate 14.00 Lactic Acid 10.00 Triethanolamine 5.00 Cetyl Alcohol 4.00 Zinc Oxide 3.00 Dimethicone Copolyol Phosphate 3.00 Sorbitan Isostearate 2.00 Isostearic Acid 1.75 Polyoxyethylene (21) Stearyl Ether 1.50 Magnesium Aluminum Silicate 0.70 Propylene Glycol 0.50 Glycerin 0.50 Xanthan Gum 0.20 Polyoxyethylene Stearyl Ether 0.20 Glydant Plus* 0.20 Fragrance 0.20 Botanical Blend 0.10 Vitamin E Linoleate 0.
10 Aloe Vera Gel 0.01 Water qs 0 1 b 0 EXAMPLE 4 A further pair of prevent and correct compositions according to the present invention are prepared from the following components.
TABLE VI PREVENT COMPOSITION COMPONENT J WEIGHT 9& Ethylhexyl p-Methoxycinnamate 7.00 Glycerin 4.00 Oxybenzone 3.00 Alkyl Polyglycoside 3.00 Cetyl Alcohol 2.50 Glycerl Monostearate 2.00 Octyl Palmitate 2.00 Silicone Fluid 1.50 Petroleum Jelly 1.00 Methyl Paraben 0.15 Propyl Paraben 0.10 Fragrance 0.10 Antifoam 0.01 Water qs TABLE VIJ CORRECT COMPOSITION a COMPONENT WEIGHT t] Glycolic Acid 7.00 Glycerin 4.00 Triethanolamine 3.00 Alkyl Polyglycoside 3.00 Cetyl Alcohol 2.50 Glyceri Monostearate 2.00 Octyl Palmitate 2.00 Silicone Fluid 1.50 Petroleum Jelly 1.00 Methyl Paraben 0.15 Propyl Paraben 0.10 Fragrance 0.10 Antifoam 0.01 Water qs EXAMPLE Still a further pair of prevent and correct compositions according to the present invention are prepared from the following components.
0 '~rnnrHtoL.-- TABLE VCOMPOSITION *PREVENT COMPOSTTTON 1ic 0 COMPONENT WEIGHT Hexyl Laurate 8.00 Isopropyl Myristate 3.00 Stearic Acid 3.00 Propylene Glycol 3.00 Cyclomethicone 3.00 Octyl Methoxycinnamate 2.00 Panthenol 1.00 Butyl Methoxydibenzoylmethane 1.00 Disodium EDTA 0.10 Fragrance 0.10 Sodium Sorbate 0.10 Water qs 0 TABLE XX CORRECT COMPOSITION COMPONENT WEIGHT J 8.00 Hexyl Laurate Isopropyl Myristate 3.00 Stearic Acid 3.00 Propylene Glycol 3.00 Cyclomethicone 3.00 L-Lactic Acid 2.00 Panthenol 1.00 Ammonia (Aqueous 26 BE) 0.30 Disodium EDTA 0.10 Fragrance 0.10 Sodium Sorbate 0.10 Water qs 0 EXAMPLE 6 Anhydrous formulations for a pair of prevent and correct compositions according to the present invention are prepared from the following components.
TABLE X PREVENT COMPOSITION COMPONENT WEIGHT Cyclomethicone 48.30 Ethyl Alcohol 24.70 Isopropyl PPG-2 Isodeceth-7- 10.00 carboxylate Octyldimethyl PABA 7.00 Benzophenone-3 6.00 Propylene Glycol 4.00 Dicaprylate/Dicaprate 0 0 TABLE XI CORRECT COMPOSITION COMPONENT _WEIGHT Cyclomethicone '48.30 Ethyl Alcohol 24.70 Isopropyl PPG-2 Isodeceth-7- 10.00 carboxylate 0 Ammonium Glycolate 7.00 Propylene Glycol 4.00 Dicaprylate/Dicaprate Hydroxycaprylic Acid 0.50 Although this invention has been described with reference to specific Examples and package embodiments, it will be apparent to one skilled in the art that various modifications may be made thereto which fall within the scope and purview of the invention.
Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.
The reference to any prior art in this specification is not, and should not be taken as, an acknowledgment or any form of suggestion that the prior art forms part of the common general knowledge in Australia.
I
Claims (23)
1. The use of a product in the manufacture of a medicament to prevent and correct skin damage, which product includes a first composition having a sunscreen present in an effective amount to prevent UV radiation from penetrating the composition to reach a user's skin, and a second composition having a C 2 -C 30 a-hydroxycarboxylic acid or salt thereof present in an effective amount to correct UV radiation induced skin damage; which first composition is stored in a first container and which second composition is stored in a second container, the first and second containers fitted with.a means for coupling same to one another; wherein the first composition is applied to the skin so as to remain in contact during daytime and to prevent UV radiation induced skin damage; and wherein the second composition is applied after application of the first composition so as to remain in contact overnight on the skin to correct for any UV radiation damage.
2. The use of a product according to claim 1 wherein the means for coupling is a threaded screw.
3. The use of a product according to claim 1 or claim 2 wherein the first and second containers are stacked one above the other and releasably locked together by the means for coupling.
4. The use of a product according to any one of claims 1 to 3 wherein the first and second containers have differently colored outside walls.
The use of a product according to claim 4 wherein the color of the outside walls of the first container is predominantly white and the color of the outside walls of the second container is of a color predominantly other than white.
6. The use of.a product according to claim 1 wherein the sunscreen is an organic substance selected form the group consisting of para-amino benzoates; salicylates; cinnamates; benzophenones; coumarins; azoles; menthyl anthralinates; polyethylene; polyamides and mixtures thereof.
7. The use of a product according to claim 1 wherein the sunscreen is present in an amount ranging from 0.1 to by weight.
8. The use of a product according to claim 1 wherein the C 2 -C3o a-hydroxycarboxylic acid is selected form the group consisting of lactic acid, glycolic acid, a- hydroxycaprylic acid and combinations thereof.
9. The use of a product according to claim 1 wherein the C 2 -C 30 a-hydroxycarboxylic acid or salt thereof is present in an amount from 0.01.to 15% by weight.
The use of a product according to claim 1 wherein the first composition has at least ten separated components in common with those of the second composition.
11. The use of a product according to claim 10 wherein the at least ten separate components are present at about equal concentrations in the first and second compositions.
12. Cosmetic method to prevent and correct skin damage, in which method is used a first composition having a sunscreen present in an effective amount to prevent UV radiation from penetrating the composition to reach a user's skin, and a second composition having a C 2 -C 30 C- hydroxycarboxylic acid or salt thereof present in an effective amount to correct UV radiation induced skin damage; which first composition is stored in a first container and which second composition is stored in a second container, the first and second containers fitted with a means for coupling same to one another; which method comprises applying the first composition to the skin so as to remain in contact during daytime and to prevent UV radiation induced skin damage; and applying the second composition after application of the first composition so as to remain in contact overnight on the skin to correct for any UV radiation damage.
13. The method according to claim 12 wherein the means for coupling is a threaded screw.
14. A method according to claim 12 or claim 13 wherein the first and second containers are stacked one above the other and releasably locked together by the means for coupling.
A method according to any one of claims 12 to 14 wherein the first and second containers have differently colored outside walls.
16. A method according to claim 15 wherein the color of the outside walls of the first container is predominantly white and the color of the outside walls of the second container is of a color predominantly other than white.
17. A method according to claim 12 wherein the sunscreen is an organic substance selected form the group consisting of para-amino benzoates.; salicylates; cinnamates; benzophenones; coumarins; azoles; menthyl anthralinates; polyethylene; polyamides and mixtures thereof.
18. A method according to claim 12 wherein the sunscreen is present in an amount ranging from 0.1 to 25% by weight.
19. A method according to claim 12 wherein the C2-C 30 a- hydroxycarboxylic acid is selected form the group consisting of lactic acid, glycolic acid, a- hydroxycaprylic acid and combinations thereof.
A method according to claim 12 wherein the C 2 -C 30 a- hydroxycarboxylic acid or salt thereof is present in an amount from 0.01 to 15% by weight.
21. A method according to claim 12 wherein the first composition has at least ten separated components in common with those of the second composition.
22. A method according to claim 21 wherein the at least ten separate components are present at about equal concentrations in the first and second compositions.
23. A cosmetic method to prevent and correct skin damage as herein described with reference to the examples and the accompanying drawing. DATED THIS 20th day of March, 2003. UNILEVER PLC By Its Patent Attorneys DAVIES COLLISON CAVE
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003201950A AU2003201950B2 (en) | 1995-05-26 | 2003-03-20 | A cosmetic product to prevent and correct skin damage |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US451940 | 1995-05-26 | ||
| AU34066/00A AU3406600A (en) | 1995-05-26 | 2000-05-12 | A cosmetic product to prevent and correct skin damage |
| AU2003201950A AU2003201950B2 (en) | 1995-05-26 | 2003-03-20 | A cosmetic product to prevent and correct skin damage |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU34066/00A Division AU3406600A (en) | 1995-05-26 | 2000-05-12 | A cosmetic product to prevent and correct skin damage |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2003201950B9 AU2003201950B9 (en) | 2003-06-12 |
| AU2003201950A1 AU2003201950A1 (en) | 2003-06-12 |
| AU2003201950B2 true AU2003201950B2 (en) | 2004-07-08 |
Family
ID=3721428
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU34066/00A Abandoned AU3406600A (en) | 1995-05-26 | 2000-05-12 | A cosmetic product to prevent and correct skin damage |
| AU2003201950A Expired AU2003201950B2 (en) | 1995-05-26 | 2003-03-20 | A cosmetic product to prevent and correct skin damage |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU34066/00A Abandoned AU3406600A (en) | 1995-05-26 | 2000-05-12 | A cosmetic product to prevent and correct skin damage |
Country Status (1)
| Country | Link |
|---|---|
| AU (2) | AU3406600A (en) |
-
2000
- 2000-05-12 AU AU34066/00A patent/AU3406600A/en not_active Abandoned
-
2003
- 2003-03-20 AU AU2003201950A patent/AU2003201950B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3406600A (en) | 2000-07-13 |
| AU2003201950B9 (en) | 2003-06-12 |
| AU2003201950A1 (en) | 2003-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0828670B1 (en) | Treatment regime for skin | |
| US6531116B1 (en) | Treatment regime for skin | |
| US5306486A (en) | Cosmetic sunscreen composition containing green tea and a sunscreen | |
| US6007797A (en) | Disappearing color sunscreen compositions | |
| CA2159606C (en) | Skin care composition containing emulsified petroleum jelly | |
| CA2072027C (en) | Cosmetic compositions | |
| US5612044A (en) | Self-tanner cosmetic compositions | |
| AU2001237397B2 (en) | Dual composition cosmetic product with a concentration sensitive and an incompatible active respectively placed within first and second compositions | |
| US4737360A (en) | Skin care compositions | |
| US5008100A (en) | Oil-in-water emulsions containing polyethylene | |
| US5425939A (en) | Thickened cosmetic compositions | |
| AU2001237397A1 (en) | Dual composition cosmetic product with a concentration sensitive and an incompatible active respectively placed within first and second compositions | |
| EP0828473B1 (en) | A cosmetic product to prevent and correct skin damage | |
| US7135165B2 (en) | Multiphase sunscreen compositions | |
| US5807561A (en) | Emulsifying system for a whitening cosmetic composition | |
| CA2166532C (en) | Cleansing composition containing hydroxy alkanoate derivatives | |
| AU2003201950B2 (en) | A cosmetic product to prevent and correct skin damage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SREP | Specification republished | ||
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |