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AU2003291689A1 - Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization - Google Patents

Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization

Info

Publication number
AU2003291689A1
AU2003291689A1 AU2003291689A AU2003291689A AU2003291689A1 AU 2003291689 A1 AU2003291689 A1 AU 2003291689A1 AU 2003291689 A AU2003291689 A AU 2003291689A AU 2003291689 A AU2003291689 A AU 2003291689A AU 2003291689 A1 AU2003291689 A1 AU 2003291689A1
Authority
AU
Australia
Prior art keywords
isomerization
prone
antibodies
pharmaceutical formulation
liquid pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003291689A
Other versions
AU2003291689A8 (en
Inventor
Aleni Flores-Nate
Supriya Gupta
Elizabet A. Kaisheva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PDL Biopharma Inc
Original Assignee
Protein Design Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Design Labs Inc filed Critical Protein Design Labs Inc
Publication of AU2003291689A8 publication Critical patent/AU2003291689A8/en
Publication of AU2003291689A1 publication Critical patent/AU2003291689A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AU2003291689A 2002-10-31 2003-10-31 Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization Abandoned AU2003291689A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42298002P 2002-10-31 2002-10-31
US60/422,980 2002-10-31
PCT/US2003/034950 WO2004039337A2 (en) 2002-10-31 2003-10-31 Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization

Publications (2)

Publication Number Publication Date
AU2003291689A8 AU2003291689A8 (en) 2004-05-25
AU2003291689A1 true AU2003291689A1 (en) 2004-05-25

Family

ID=32230402

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003291689A Abandoned AU2003291689A1 (en) 2002-10-31 2003-10-31 Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization

Country Status (2)

Country Link
AU (1) AU2003291689A1 (en)
WO (1) WO2004039337A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1783222T3 (en) 1998-10-23 2012-07-09 Kirin Amgen Inc Dimeric thrombopoietic peptidomimetics that bind to MPL receptor and have thrombopoietic activity
CA2607663C (en) 2005-05-19 2014-08-12 Amgen Inc. Compositions and methods for increasing the stability of antibodies
EP1909838A2 (en) * 2005-07-29 2008-04-16 Amgen Inc. Formulations that inhibit protein aggregation
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
WO2008048430A2 (en) * 2006-10-18 2008-04-24 Amgen Inc. Identification, quantification and conversion of succinimide in proteins
US7705132B2 (en) 2006-10-20 2010-04-27 Amgen Inc. Stable polypeptide formulations
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
JP5784907B2 (en) 2007-12-28 2015-09-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Recombinant VWF formulation
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
AR074054A1 (en) 2008-10-21 2010-12-22 Baxter Healthcare Sa PHARMACEUTICAL FORMULATIONS OF VIO WILLEBRAND RECOMBINANT LIOFILIZED FACTOR
KR101752508B1 (en) 2008-11-07 2017-06-29 백스터 인터내셔널 인코포레이티드 Factor viii formulations
SMT202000095T1 (en) 2010-05-14 2020-03-13 Amgen Inc High concentration anti-sclerostin antibody formulations
CA2924448C (en) * 2013-11-29 2021-12-14 Genentech, Inc. Antibody selection apparatus and methods
US10294306B2 (en) 2015-05-28 2019-05-21 Bio-Rad Laboratories, Inc. Affinity ligands and methods relating thereto
WO2018200533A1 (en) 2017-04-28 2018-11-01 Amgen Inc. Excipients to reduce the viscosity of antibody formulations and formulation compositions
BR112020000321A2 (en) 2017-07-07 2020-07-14 Baxalta Incorporated method for treating gastrointestinal bleeding in a subject with von willebrand disease.
FI3648787T3 (en) 2017-07-07 2025-01-20 Takeda Pharmaceuticals Co Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf
AU2018334502A1 (en) 2017-09-15 2020-03-12 Amgen Inc. Process for lyophilized pharmaceutical formulation of a therapeutic protein
MX2020008219A (en) 2018-02-08 2020-10-22 Amgen Inc Low ph pharmaceutical antibody formulation.
BR112020019057A2 (en) 2018-03-21 2020-12-29 Baxalta Incorporated METHOD FOR OBTAINING A COMPOSITION AND PHARMACEUTICAL COMPOSITION.
US20210236636A1 (en) 2018-07-31 2021-08-05 Amgen Inc. Pharmaceutical formulations of masked antibodies
US12128090B2 (en) 2019-02-01 2024-10-29 Takeda Pharmaceutical Company Limited Methods of prophylactic treatment using recombinant VWF (rVWF)
JP7266108B2 (en) 2019-02-18 2023-04-27 イーライ リリー アンド カンパニー therapeutic antibody formulation
WO2021050718A1 (en) 2019-09-11 2021-03-18 Baxalta Incorporated Methods of treatment related to complexes of von willebrand factor and complement c1q
MX2022009492A (en) 2020-02-04 2022-11-09 Takeda Pharmaceuticals Co Treatment of menorrhagia in patients with severe von willebrand disease by administration of recombinant vwf.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434680B (en) * 1983-01-21 1984-08-06 Karl Arne Lundblad APPLICATION OF A SALT SOLUTION OF MONOCLONAL ANTIBODIES WITH RELATIVE HIGH SALT CONTENT IN BLOOD GROUP DETERMINATION
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation

Also Published As

Publication number Publication date
AU2003291689A8 (en) 2004-05-25
WO2004039337A2 (en) 2004-05-13
WO2004039337A3 (en) 2004-12-09

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase