[go: up one dir, main page]

AU2003286502A1 - Contiguous capillary electrospray sources and analytical device - Google Patents

Contiguous capillary electrospray sources and analytical device

Info

Publication number
AU2003286502A1
AU2003286502A1 AU2003286502A AU2003286502A AU2003286502A1 AU 2003286502 A1 AU2003286502 A1 AU 2003286502A1 AU 2003286502 A AU2003286502 A AU 2003286502A AU 2003286502 A AU2003286502 A AU 2003286502A AU 2003286502 A1 AU2003286502 A1 AU 2003286502A1
Authority
AU
Australia
Prior art keywords
analytical device
electrospray sources
contiguous capillary
capillary electrospray
contiguous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003286502A
Other languages
English (en)
Other versions
AU2003286502A8 (en
Inventor
Thomas P. Conrads
Haleem J. Isaaq
George Janini
Timothy D. Veenstra
Kenneth L. Wilkens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of AU2003286502A8 publication Critical patent/AU2003286502A8/xx
Publication of AU2003286502A1 publication Critical patent/AU2003286502A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/0255—Discharge apparatus, e.g. electrostatic spray guns spraying and depositing by electrostatic forces only
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/053—Arrangements for supplying power, e.g. charging power
    • B05B5/0533—Electrodes specially adapted therefor; Arrangements of electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
AU2003286502A 2002-10-21 2003-10-20 Contiguous capillary electrospray sources and analytical device Abandoned AU2003286502A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42000302P 2002-10-21 2002-10-21
US60/420,003 2002-10-21
PCT/US2003/033200 WO2004038752A2 (fr) 2002-10-21 2003-10-20 Sources d'electronebulisation a capillaires contigus et dispositif analytique

Publications (2)

Publication Number Publication Date
AU2003286502A8 AU2003286502A8 (en) 2004-05-13
AU2003286502A1 true AU2003286502A1 (en) 2004-05-13

Family

ID=32176498

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003286502A Abandoned AU2003286502A1 (en) 2002-10-21 2003-10-20 Contiguous capillary electrospray sources and analytical device

Country Status (3)

Country Link
US (1) US7544932B2 (fr)
AU (1) AU2003286502A1 (fr)
WO (1) WO2004038752A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003286502A1 (en) 2002-10-21 2004-05-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Contiguous capillary electrospray sources and analytical device
US7087895B1 (en) * 2003-06-07 2006-08-08 Musc Foundation For Research Development Electrospray ionization using pointed fibers
CN101137446B (zh) 2005-02-11 2010-06-09 巴特尔纪念研究所 电流体动力气雾剂分配装置及喷射方法
WO2008089143A1 (fr) * 2007-01-12 2008-07-24 Board Of Regents, The University Of Texas System Interface de techniques de séparation à faible débit
WO2008151121A1 (fr) * 2007-06-01 2008-12-11 Analytica Of Branford, Inc. Amplification de la performance d'une source d'ions sous pression atmosphérique
US8449746B2 (en) * 2010-07-16 2013-05-28 Waters Technologies Corporation Systems and methods for coupling molecule separation devices to analytical instruments
DE102010041433A1 (de) * 2010-09-27 2012-03-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kapillarröhrchen für die Elektrophorese
US9275844B2 (en) * 2012-05-16 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for nanoflow liquid jet and serial femtosecond x-ray protein crystallography
US8754370B1 (en) * 2013-03-07 2014-06-17 Battelle Memorial Institute Sheathless interface for coupling capillary electrophoresis with mass spectrometry
WO2014179361A1 (fr) * 2013-04-29 2014-11-06 Birmingham Joseph G Système et procédé de pulvérisation électrique à courant alternatif haute tension
US20180178227A1 (en) 2015-05-28 2018-06-28 Georgia Tech Research Corporation Systems and methods of electron beam induced processing
CN106373856B (zh) * 2015-07-23 2019-02-15 北京理工大学 电喷雾离子源及包含该离子源的lc-ms联用接口
JP2020527831A (ja) * 2017-07-07 2020-09-10 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド エレクトロスプレーインターフェースデバイスおよび関連付けられた方法
US20190019662A1 (en) * 2017-07-14 2019-01-17 Purdue Research Foundation Electrophoretic mass spectrometry probes and systems and uses thereof
US12259370B2 (en) 2020-03-08 2025-03-25 The Board Of Regents Of The University Of Oklahoma Electrospray assisted capillary device for processing ultra low-volume samples
US11988652B2 (en) 2020-11-18 2024-05-21 Thermo Finnigan Llc Packed tip electrospray emitter
CN112834596B (zh) * 2020-12-30 2022-08-30 武汉大学 一种基于丙烯酰胺导电凝胶的无鞘流ce-ms接口装置及应用

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708782A (en) * 1986-09-15 1987-11-24 Sepragen Corporation Chromatography column-electrophoresis system
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4933404A (en) * 1987-11-27 1990-06-12 Battelle Memorial Institute Processes for microemulsion polymerization employing novel microemulsion systems
EP0343233B1 (fr) * 1987-11-27 1994-02-02 Battelle Memorial Institute Separation de micelles a phase inverse et de fluides a l'etat surcritique
US4995231A (en) * 1988-02-01 1991-02-26 Olin Corporation Performance arcjet thruster
US5266205A (en) * 1988-02-04 1993-11-30 Battelle Memorial Institute Supercritical fluid reverse micelle separation
USRE34757E (en) * 1988-04-05 1994-10-18 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4994165A (en) * 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
USRE35102E (en) * 1989-06-01 1995-11-28 The Board Of Trustees Of The Leland Stanford Junior University Capillary electrophoretic device employing structure permitting electrical contact through ionic movement
US4908116A (en) * 1989-06-01 1990-03-13 The Board Of Trustees At The Leland Stanford Junior University Capillary electrophoretic device employing structure permitting electrical contact through ionic movement
US5073713A (en) * 1990-05-29 1991-12-17 Battelle Memorial Institute Detection method for dissociation of multiple-charged ions
US5175996A (en) * 1990-10-16 1993-01-05 Olin Corporation Apparatus for propellant flow control at low mass flow rates in zero G environment
US5267584A (en) * 1990-10-16 1993-12-07 Smith Richard D Method of fluid flow control using a porous media
US5245185A (en) * 1991-11-05 1993-09-14 Georgia Tech Research Corporation Interface device and process to couple planar electrophoresis with spectroscopic methods of detection
US5245186A (en) * 1991-11-18 1993-09-14 The Rockefeller University Electrospray ion source for mass spectrometry
US5192865A (en) * 1992-01-14 1993-03-09 Cetac Technologies Inc. Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
NZ268326A (en) * 1993-07-19 1997-12-19 Angiogenesis Tech Inc Stent with a coating comprising an anti-angiogenic compound, such as taxol, and a polymeric carrier
US5423964A (en) * 1993-08-02 1995-06-13 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
DE4444229C2 (de) * 1994-03-10 1996-07-25 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer
US6147347A (en) * 1994-03-15 2000-11-14 Hitachi, Ltd. Ion source and mass spectrometer instrument using the same
DE4415480C2 (de) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US5523566A (en) * 1994-07-20 1996-06-04 Fuerstenau; Stephen D. Method for detection and analysis of inorganic ions in aqueous solutions by electrospray mass spectrometry
JP3415682B2 (ja) * 1994-08-10 2003-06-09 株式会社日立製作所 キャピラリー電気泳動・質量分析計
AU3640295A (en) * 1994-09-23 1996-04-09 Trustees Of The University Of Pennsylvania, The Mass spectrometer for gas tension measurer
US5571398A (en) * 1994-12-23 1996-11-05 Northeastern University Precise capillary electrophoretic interface for sample collection or analysis
EP0753143B1 (fr) * 1995-01-27 2004-12-01 Northeastern University Procede de formation de revetement hydrophile stable lie de maniere covalente a base d'alcool polyvinylique pour electrophorese capillaire
US5800692A (en) 1995-04-17 1998-09-01 Mayo Foundation For Medical Education And Research Preseparation processor for use in capillary electrophoresis
US5545304A (en) * 1995-05-15 1996-08-13 Battelle Memorial Institute Ion current detector for high pressure ion sources for monitoring separations
US5587582A (en) * 1995-05-19 1996-12-24 Cornell Research Foundation, Inc. Self-aligning liquid junction
JP3353561B2 (ja) * 1995-09-07 2002-12-03 株式会社日立製作所 溶液の質量分析に関する方法と装置
US5879949A (en) * 1995-11-22 1999-03-09 Board Of Supervisors Of Louisiana State University & Agricultural And Mechanical College Apparatus and method for rapid on-line electrochemistry and mass spectrometry
US6068749A (en) * 1996-01-19 2000-05-30 Northeastern University Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5580434A (en) * 1996-02-29 1996-12-03 Hewlett-Packard Company Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer
US6116516A (en) * 1996-05-13 2000-09-12 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
AU737078C (en) * 1996-05-24 2002-05-02 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
US5788166A (en) * 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US6110343A (en) * 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
US6515016B2 (en) * 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) * 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
AU6266998A (en) 1997-02-06 1998-08-26 Board Of Regents, The University Of Texas System A novel sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry using an in-capillary electrode
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
US5954959A (en) * 1997-05-09 1999-09-21 Battelle Memorial Institute Microdialysis unit for molecular weight separation
US6187190B1 (en) 1997-05-09 2001-02-13 Battelle Memorial Institute Apparatus for molecular weight separation
US6297499B1 (en) * 1997-07-17 2001-10-02 John B Fenn Method and apparatus for electrospray ionization
US5993633A (en) * 1997-07-31 1999-11-30 Battelle Memorial Institute Capillary electrophoresis electrospray ionization mass spectrometry interface
JP2001516140A (ja) * 1997-09-12 2001-09-25 アナリティカ オブ ブランフォード インコーポレーテッド 多重試料導入質量分光測定法
US6054709A (en) * 1997-12-05 2000-04-25 The University Of British Columbia Method and apparatus for determining the rates of reactions in liquids by mass spectrometry
US6379971B1 (en) * 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US5975426A (en) * 1998-05-14 1999-11-02 Waters Investments Limited Use of porous beads as a tip for nano-electrospray
US5997746A (en) * 1998-05-29 1999-12-07 New Objective Inc. Evaporative packing of capillary columns
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
US6333088B1 (en) * 1999-01-13 2001-12-25 Uop Llc Compound capillary assembly and use in separative transport
US6633031B1 (en) * 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
US20020055184A1 (en) * 1999-09-08 2002-05-09 Stephen Naylor Systems for detecting analytes
US6610184B2 (en) * 2001-11-14 2003-08-26 Applied Materials, Inc. Magnet array in conjunction with rotating magnetron for plasma sputtering
US6670607B2 (en) * 2000-01-05 2003-12-30 The Research Foundation Of State University Of New York Conductive polymer coated nano-electrospray emitter
WO2001053819A1 (fr) * 2000-01-18 2001-07-26 Advion Biosciences, Inc. Milieu de separation, systeme a buses d'electronebulisation multiples et procede associe
US20030133841A1 (en) 2000-02-18 2003-07-17 Dagmar Weber End element for capillaries or chip channels
KR100632536B1 (ko) * 2000-03-20 2006-10-09 에스케이 주식회사 파울링 제거용 세정제 조성물 및 이의 사용방법
IL152620A (en) * 2000-05-05 2010-05-17 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
CA2409860A1 (fr) 2000-05-22 2001-11-29 David D. Y. Chen Lentille a ions fonctionnant a la pression atmospherique, concue pour generer un flux d'ions plus important et plus stable
EP1309381A4 (fr) * 2000-06-09 2003-08-27 Advion Biosciences Inc Modification de surface d'un monolithe polymere poreux et produits ainsi obtenus
US6744041B2 (en) * 2000-06-09 2004-06-01 Edward W Sheehan Apparatus and method for focusing ions and charged particles at atmospheric pressure
US6429092B1 (en) 2000-06-19 2002-08-06 Infineon Technologies Ag Collar formation by selective oxide deposition
US6759205B2 (en) * 2000-06-29 2004-07-06 University Of Maryland Construction of a strain of Bacillus subtilis 168 that displays the sublancin lantibiotic on the surface of the cell
US7033766B2 (en) * 2000-06-29 2006-04-25 University Of Maryland Office Of Technology Commercialization Construction and screening of lantibody display libraries
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
AU2001285228A1 (en) 2000-08-24 2002-03-04 Newton Scientific, Inc. Sample introduction interface for analytical processing of a sample placed on a substrate
HK1054587A1 (zh) * 2000-10-03 2003-12-05 戴安公司 液相色谱-质谱分析仪(lc-ms)分析中的驻峰方法和系统
AU2001296234A1 (en) * 2000-10-05 2002-04-15 Pharmacia And Upjohn Company Method for determining chemical reactivity
US7070682B2 (en) * 2001-01-16 2006-07-04 Cheng Lee Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus
US20020100714A1 (en) * 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
US6818454B2 (en) * 2001-02-16 2004-11-16 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
US6657191B2 (en) * 2001-03-02 2003-12-02 Bruker Daltonics Inc. Means and method for multiplexing sprays in an electrospray ionization source
AU2002360282A1 (en) * 2001-10-19 2003-06-10 West Virginia University Research Corporation Microflludic system for proteome analysis
AU2003286502A1 (en) 2002-10-21 2004-05-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Contiguous capillary electrospray sources and analytical device

Also Published As

Publication number Publication date
US20060057556A1 (en) 2006-03-16
US7544932B2 (en) 2009-06-09
AU2003286502A8 (en) 2004-05-13
WO2004038752A3 (fr) 2004-07-29
WO2004038752A2 (fr) 2004-05-06

Similar Documents

Publication Publication Date Title
AU2003289373A1 (en) Thin analyzing device
AU2003217757A1 (en) Capillary evaporator
AU2003275668A1 (en) Analyzing tool and device
AU2003223514A1 (en) Lighting device and method
AU2002352746A1 (en) Sample chip
AU2003237803A1 (en) Lancet device
AU2003244122A1 (en) Biomolecule analyzer
AU2003286502A1 (en) Contiguous capillary electrospray sources and analytical device
AU2003212311A1 (en) Capillary membrane and device for production thereof
AU2003238705A1 (en) Electron-emitting device and manufacturing method thereof
AU2002951784A0 (en) Moisture analyser
AU2003268457A1 (en) Biomap analysis
AU2003237282A1 (en) Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry
EP1573502A3 (fr) Dispositif de saisie rapide
AU2003206416A1 (en) Protein standard for estimating size and mass
AU2003289154A1 (en) Analyzing device
AU2003265881A1 (en) Semiconductor device and method therefor
AU2003281615A1 (en) NOVEL Notch-ORIGIN POLYPEPTIDES AND BIOMARKERS AND REAGENTS USING THE SAME
AU2003264236A1 (en) Capillary rheometer
AU2002317334A1 (en) Analytical technique
AU2003261919A1 (en) Content editing device
AU2003211433A1 (en) Humidity conditioning device
AU2003236251A1 (en) Semiconductor device and method for assembling the same
AU2003258990A1 (en) Sensitizer-labeled analyte detection
AU2003285292A1 (en) Pressing device

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase