AU2003283152A1 - Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine - Google Patents
Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysineInfo
- Publication number
- AU2003283152A1 AU2003283152A1 AU2003283152A AU2003283152A AU2003283152A1 AU 2003283152 A1 AU2003283152 A1 AU 2003283152A1 AU 2003283152 A AU2003283152 A AU 2003283152A AU 2003283152 A AU2003283152 A AU 2003283152A AU 2003283152 A1 AU2003283152 A1 AU 2003283152A1
- Authority
- AU
- Australia
- Prior art keywords
- benzyloxycarbonyl
- polymerisation
- glutamate
- alanine
- tyrosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- OJTJKAUNOLVMDX-LBPRGKRZSA-N (2s)-6-amino-2-(phenylmethoxycarbonylamino)hexanoic acid Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 OJTJKAUNOLVMDX-LBPRGKRZSA-N 0.000 title 1
- HFZKKJHBHCZXTQ-JTQLQIEISA-N (4s)-4-azaniumyl-5-oxo-5-phenylmethoxypentanoate Chemical compound OC(=O)CC[C@H](N)C(=O)OCC1=CC=CC=C1 HFZKKJHBHCZXTQ-JTQLQIEISA-N 0.000 title 1
- 108010072051 Glatiramer Acetate Proteins 0.000 title 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 title 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 title 1
- 229960003776 glatiramer acetate Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Polyamides (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002411786A CA2411786C (fr) | 2002-11-13 | 2002-11-13 | Methode de preparation de polypeptide 1 |
| CA2,411,786 | 2002-11-13 | ||
| US10/326,994 | 2002-12-24 | ||
| US10/326,994 US7049399B2 (en) | 2002-11-13 | 2002-12-24 | Process for the preparation of polypeptide 1 |
| PCT/CA2003/001744 WO2004043995A2 (fr) | 2002-11-13 | 2003-11-13 | Procede de preparation de polypeptide 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003283152A8 AU2003283152A8 (en) | 2004-06-03 |
| AU2003283152A1 true AU2003283152A1 (en) | 2004-06-03 |
Family
ID=32313425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003283152A Abandoned AU2003283152A1 (en) | 2002-11-13 | 2003-11-13 | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1565486A2 (fr) |
| AU (1) | AU2003283152A1 (fr) |
| WO (1) | WO2004043995A2 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7429374B2 (en) | 2001-12-04 | 2008-09-30 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
| PL1797109T3 (pl) * | 2004-09-09 | 2016-11-30 | Mieszaniny polipeptydów, kompozycje zawierające je i procesy ich wytwarzania oraz ich zastosowania | |
| ES2338138T3 (es) * | 2004-09-09 | 2010-05-04 | Teva Pharmaceutical Industries Ltd | Proceso para la preparacion de mezclas de polipeptidos utilizando acido bromhidrico purificado. |
| AR052321A1 (es) | 2004-10-29 | 2007-03-14 | Sandoz Ag | Procesos para la preparacion de un polipeptido |
| EP1838326A4 (fr) * | 2005-02-02 | 2009-09-30 | Teva Pharma | Procede de production de melanges de polypeptides par hydrogenolyse |
| WO2008006026A1 (fr) * | 2006-07-05 | 2008-01-10 | Momenta Pharmaceuticals, Inc. | Procédé amélioré de préparation de copolymère-1 |
| CN101743470A (zh) | 2007-06-21 | 2010-06-16 | 动量制药公司 | 共聚物测定 |
| WO2009016643A1 (fr) | 2007-07-31 | 2009-02-05 | Natco Pharma Limited | Procédé de préparation de l'acétate de glatiramer (copolymère-1) |
| RU2010146489A (ru) | 2008-04-16 | 2012-05-27 | Момента Фармасьютикалз, Инк. (Us) | Анализ композиций сополимера аминокислот |
| SI2949335T1 (sl) | 2009-08-20 | 2017-05-31 | Yeda Research & Development Company, Ltd. | Nizkofrekventna terapija z glatiramer acetatom |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
| ES2602977T3 (es) | 2010-10-11 | 2017-02-23 | Teva Pharmaceutical Industries Ltd. | Biomarcadores de citocinas como biomarcadores predictivos de la respuesta clínica para acetato de glatirámero |
| WO2013009885A2 (fr) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation de diéthylamide de copolymère |
| TW201326399A (zh) | 2011-10-10 | 2013-07-01 | Teva Pharma | 用於預測對格拉替雷（ｇｌａｔｉｒａｍｅｒ）醋酸鹽之臨床反應之單核苷酸多型性之判定 |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HRP20250396T1 (hr) | 2016-08-31 | 2025-05-23 | Mapi Pharma Ltd. | Depo sustavi koji sadrže glatiramer acetat |
| AU2018242998B2 (en) | 2017-03-26 | 2023-11-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) * | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
-
2003
- 2003-11-13 WO PCT/CA2003/001744 patent/WO2004043995A2/fr not_active Ceased
- 2003-11-13 EP EP03775017A patent/EP1565486A2/fr not_active Withdrawn
- 2003-11-13 AU AU2003283152A patent/AU2003283152A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004043995A3 (fr) | 2004-10-07 |
| WO2004043995A2 (fr) | 2004-05-27 |
| AU2003283152A8 (en) | 2004-06-03 |
| EP1565486A2 (fr) | 2005-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |