AU2003276156A1 - Selected cgrp antagonists, method for production and use thereof as medicament - Google Patents

Selected cgrp antagonists, method for production and use thereof as medicament Download PDF

Info

Publication number: AU2003276156A1
Authority: AU; Australia
Prior art keywords: piperidin; oxo; benzyl; methyl; amino
Prior art date: 2002-10-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2003276156A

Other languages

English (en)

Inventor

Eckhart Bauer

Henri Doods

Alexander Dreyer

Arndt Kirsten

Philipp Lustenberger

Stephan Georg Muller

Klaus Rudolf

Marcus Schindler

Dirk Stenkamp

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Boehringer Ingelheim Pharma GmbH and Co KG

Boehringer Ingelheim Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-25

Filing date

2003-10-23

Publication date

2004-05-13

2003-10-23 Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG

2004-05-13 Publication of AU2003276156A1 publication Critical patent/AU2003276156A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Addiction (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AU2003276156A 2002-10-25 2003-10-23 Selected cgrp antagonists, method for production and use thereof as medicament Abandoned AU2003276156A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10250080.0		2002-10-25
DE10250080A DE10250080A1 (de)	2002-10-25	2002-10-25	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP2003/011762 WO2004037810A1 (de)	2002-10-25	2003-10-23	Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel

Publications (1)

Publication Number	Publication Date
AU2003276156A1 true AU2003276156A1 (en)	2004-05-13

Family

ID=32103086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2003276156A Abandoned AU2003276156A1 (en)	2002-10-25	2003-10-23	Selected cgrp antagonists, method for production and use thereof as medicament

Country Status (27)

Country	Link
EP (1)	EP1558600B1 (es)
JP (1)	JP4401296B2 (es)
KR (1)	KR20050074970A (es)
CN (1)	CN1708493A (es)
AR (1)	AR041718A1 (es)
AT (1)	ATE394392T1 (es)
AU (1)	AU2003276156A1 (es)
BR (1)	BR0315665A (es)
CA (1)	CA2503455A1 (es)
CO (1)	CO5570704A2 (es)
DE (2)	DE10250080A1 (es)
DK (1)	DK1558600T3 (es)
EA (1)	EA009219B1 (es)
EC (1)	ECSP055747A (es)
ES (1)	ES2306918T3 (es)
HR (1)	HRP20050364A2 (es)
IL (1)	IL168056A0 (es)
MX (1)	MXPA05004375A (es)
NO (1)	NO20052496L (es)
PE (1)	PE20040592A1 (es)
PL (1)	PL376450A1 (es)
RS (1)	RS20050311A (es)
TW (1)	TW200413317A (es)
UA (1)	UA79323C2 (es)
UY (1)	UY28034A1 (es)
WO (1)	WO2004037810A1 (es)
ZA (1)	ZA200502248B (es)

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US7439237B2 (en)	2005-04-15	2008-10-21	Boehringer Ingelheim International Gmbh	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
US7479488B2 (en)	2004-03-29	2009-01-20	Boehringer Ingelheim International Gmbh	Selected CGRP—antagonists, process for preparing them and their use as pharmaceutical compositions

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EP1481965B1 (en) *	2002-02-07	2015-07-29	Hitoshi Endo	Aromatic amino acid derivatives and medicinal compositions
US7842808B2 (en)	2002-06-05	2010-11-30	Bristol-Myers Squibb Company	Anti-migraine spirocycles
US7220862B2 (en)	2002-06-05	2007-05-22	Bristol-Myers Squibb Company	Calcitonin gene related peptide receptor antagonists
US7595312B2 (en)	2002-10-25	2009-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
WO2005004869A1 (en) *	2003-07-07	2005-01-20	Boehringer Ingelheim International Gmbh	Use of cgrp antagonists in treatment and prevention of hot flushes in prostate cancer patients
US7569578B2 (en)	2003-12-05	2009-08-04	Bristol-Meyers Squibb Company	Heterocyclic anti-migraine agents
TW200533398A (en)	2004-03-29	2005-10-16	Bristol Myers Squibb Co	Novel therapeutic agents for the treatment of migraine
DE102004018795A1 (de)	2004-04-15	2005-10-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102004018796A1 (de) *	2004-04-15	2005-11-03	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7696195B2 (en)	2004-04-22	2010-04-13	Boehringer Ingelheim International Gmbh	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
WO2006031513A2 (en) *	2004-09-09	2006-03-23	Merck & Co., Inc.	Aryl spirolactam cgrp receptor antagonists
US7384930B2 (en)	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en)	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en)	2004-12-03	2008-11-11	Bristol-Myers Squibb Company	Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
DE102004063752A1 (de) *	2004-12-29	2006-07-13	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung ausgewählter CGRP-Antagonisten zur Bekämpfung menopausaler Hitzewallungen
DE102004063753A1 (de) *	2004-12-29	2006-07-13	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung ausgewählter CGRP-Antagonisten in Kombination mit anderen Arzneistoffen gegen Migräne für die Behandlung von Migräne
DE102004063755A1 (de) *	2004-12-29	2006-07-20	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von CGRP-Antagonisten zur Behandlung und Vorbeugung von Hitzewallungen bei Patienten mit Prostatakrebs
EP1770091A1 (de)	2005-09-29	2007-04-04	Boehringer Ingelheim Pharma GmbH & Co. KG	CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7491717B2 (en)	2005-03-23	2009-02-17	Boehringer Ingelheim International Gmbh	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
CN101146799A (zh)	2005-03-23	2008-03-19	贝林格尔·英格海姆国际有限公司	Cgrp拮抗剂、其制备方法以及其作为药物的用途
DE102005038831A1 (de) *	2005-08-17	2007-02-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7834007B2 (en)	2005-08-25	2010-11-16	Bristol-Myers Squibb Company	CGRP antagonists
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EP1770086A1 (de) *	2005-09-29	2007-04-04	Boehringer Ingelheim Pharma GmbH & Co. KG	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102005050892A1 (de) *	2005-10-21	2007-04-26	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102006017827A1 (de) *	2006-04-13	2007-10-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue kristalline Verbindungen
MX2008015562A (es) *	2006-06-08	2008-12-17	Boehringer Ingelheim Int	Tratamiento de trastornos gastrointestinales con antagonistas de cgrp.
DE102007038250A1 (de) *	2007-08-13	2009-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neues Herstellverfahren
NZ585347A (en)	2007-10-18	2011-09-30	Boehringer Ingelheim Int	Cgrp antagonists
EP2065381A1 (de)	2007-10-18	2009-06-03	Boehringer Ingelheim Pharma GmbH & Co. KG	CGRP Antagonisten
CA2705405A1 (en)	2007-11-22	2009-05-28	Boehringer Ingelheim International Gmbh	New compounds
CA2737348C (en)	2008-08-01	2015-12-08	Mitsui Chemicals Agro, Inc.	Amide derivative, pest control agent containing the amide derivative, and pest controlling method
PT2396081T (pt)	2009-02-16	2017-07-11	Nogra Pharma Ltd	Compostos alquilamido e suas utilizações
EP2811993B1 (en)	2012-02-09	2019-10-09	Nogra Pharma Limited	Methods of treating fibrosis
US10870660B2 (en)	2016-07-28	2020-12-22	Shionogi & Co., Ltd.	Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
DK3668853T3 (da)	2017-08-16	2021-12-06	Glaxosmithkline Ip Dev Ltd	Nye forbindelser
CA3089498A1 (en)	2018-01-26	2019-08-01	Shionogi & Co., Ltd.	Condensed ring compounds having dopamine d3 receptor antagonistic effect
SI3921299T1 (sl)	2019-02-08	2025-03-31	Nogra Pharma Limited	Postopek izdelave 3-(4'-aminofenil)-2-metoksipropionske kisline in njenih analogov in vmesnih proizvodov

Family Cites Families (2)

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Publication number	Priority date	Publication date	Assignee	Title
JP2002525371A (ja) *	1998-09-30	2002-08-13	メルクシャープエンドドームリミテッド	Ｃｇｒｐリガンドとしてのベンゾイミダゾリニルピペリジン
DE19937304C2 (de) *	1999-08-10	2003-08-21	Boehringer Ingelheim Pharma	Verwendung von CGRP-Antagonisten zur Bekämpfung menopausaler Hitzewallungen

2002
- 2002-10-25 DE DE10250080A patent/DE10250080A1/de not_active Withdrawn
2003
- 2003-10-22 UY UY28034A patent/UY28034A1/es not_active Application Discontinuation
- 2003-10-23 AU AU2003276156A patent/AU2003276156A1/en not_active Abandoned
- 2003-10-23 DK DK03809317T patent/DK1558600T3/da active
- 2003-10-23 RS YUP-2005/0311A patent/RS20050311A/sr unknown
- 2003-10-23 CN CNA2003801020040A patent/CN1708493A/zh active Pending
- 2003-10-23 JP JP2004545963A patent/JP4401296B2/ja not_active Expired - Fee Related
- 2003-10-23 AT AT03809317T patent/ATE394392T1/de active
- 2003-10-23 EA EA200500600A patent/EA009219B1/ru not_active IP Right Cessation
- 2003-10-23 DE DE50309807T patent/DE50309807D1/de not_active Expired - Lifetime
- 2003-10-23 UA UAA200504872A patent/UA79323C2/uk unknown
- 2003-10-23 KR KR1020057007144A patent/KR20050074970A/ko not_active Withdrawn
- 2003-10-23 PL PL03376450A patent/PL376450A1/xx not_active Application Discontinuation
- 2003-10-23 MX MXPA05004375A patent/MXPA05004375A/es not_active Application Discontinuation
- 2003-10-23 PE PE2003001077A patent/PE20040592A1/es not_active Application Discontinuation
- 2003-10-23 HR HR20050364A patent/HRP20050364A2/hr not_active Application Discontinuation
- 2003-10-23 WO PCT/EP2003/011762 patent/WO2004037810A1/de not_active Ceased
- 2003-10-23 CA CA002503455A patent/CA2503455A1/en not_active Abandoned
- 2003-10-23 ES ES03809317T patent/ES2306918T3/es not_active Expired - Lifetime
- 2003-10-23 EP EP03809317A patent/EP1558600B1/de not_active Expired - Lifetime
- 2003-10-23 BR BR0315665-6A patent/BR0315665A/pt not_active IP Right Cessation
- 2003-10-24 AR ARP030103889A patent/AR041718A1/es unknown
- 2003-10-24 TW TW092129640A patent/TW200413317A/zh unknown
2005
- 2005-03-17 ZA ZA200502248A patent/ZA200502248B/en unknown
- 2005-04-14 IL IL168056A patent/IL168056A0/en unknown
- 2005-04-25 EC EC2005005747A patent/ECSP055747A/es unknown
- 2005-05-24 NO NO20052496A patent/NO20052496L/no not_active Application Discontinuation
- 2005-05-24 CO CO05050511A patent/CO5570704A2/es not_active Application Discontinuation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7479488B2 (en)	2004-03-29	2009-01-20	Boehringer Ingelheim International Gmbh	Selected CGRP—antagonists, process for preparing them and their use as pharmaceutical compositions
US7700598B2 (en)	2004-03-29	2010-04-20	Boehringer Ingelheim International Gmbh	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
US7439237B2 (en)	2005-04-15	2008-10-21	Boehringer Ingelheim International Gmbh	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

Also Published As

Publication number	Publication date
ZA200502248B (en)	2006-08-30
JP2006516244A (ja)	2006-06-29
CO5570704A2 (es)	2005-10-31
DE10250080A1 (de)	2004-05-13
ATE394392T1 (de)	2008-05-15
JP4401296B2 (ja)	2010-01-20
WO2004037810A1 (de)	2004-05-06
EP1558600A1 (de)	2005-08-03
EP1558600B1 (de)	2008-05-07
AR041718A1 (es)	2005-05-26
UY28034A1 (es)	2004-05-31
NO20052496D0 (no)	2005-05-24
ECSP055747A (es)	2005-07-06
PE20040592A1 (es)	2004-10-27
HRP20050364A2 (en)	2006-05-31
CA2503455A1 (en)	2004-05-06
KR20050074970A (ko)	2005-07-19
RS20050311A (sr)	2007-08-03
EA009219B1 (ru)	2007-12-28
ES2306918T3 (es)	2008-11-16
UA79323C2 (en)	2007-06-11
NO20052496L (no)	2005-06-24
PL376450A1 (en)	2005-12-27
BR0315665A (pt)	2005-08-30
EA200500600A1 (ru)	2006-02-24
DE50309807D1 (de)	2008-06-19
DK1558600T3 (da)	2008-09-01
CN1708493A (zh)	2005-12-14
IL168056A0 (en)	2009-02-11
MXPA05004375A (es)	2005-07-05
TW200413317A (en)	2004-08-01

Publication	Publication Date	Title
AU2003276156A1 (en)	2004-05-13	Selected cgrp antagonists, method for production and use thereof as medicament
US7700598B2 (en)	2010-04-20	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
US20100113411A1 (en)	2010-05-06	Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
US7700589B2 (en)	2010-04-20	CGRP antagonists
AU783275B2 (en)	2005-10-06	Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
US7985747B2 (en)	2011-07-26	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
NZ540051A (en)	2008-02-29	Selected CGRP antagonists, method for production and use thereof as medicament
NZ540006A (en)	2007-05-31	Process of production and use of CGRP antagonists for the treatment of headaches and cardiovascular diseases

Legal Events

Date	Code	Title	Description
2009-05-21	MK4	Application lapsed section 142(2)(d) - no continuation fee paid for the application