AU2003272175A1 - Reactivation of wild type p53 in human tumour cells by a low molecular weight compound - Google Patents
Reactivation of wild type p53 in human tumour cells by a low molecular weight compoundInfo
- Publication number
- AU2003272175A1 AU2003272175A1 AU2003272175A AU2003272175A AU2003272175A1 AU 2003272175 A1 AU2003272175 A1 AU 2003272175A1 AU 2003272175 A AU2003272175 A AU 2003272175A AU 2003272175 A AU2003272175 A AU 2003272175A AU 2003272175 A1 AU2003272175 A1 AU 2003272175A1
- Authority
- AU
- Australia
- Prior art keywords
- reactivation
- molecular weight
- low molecular
- wild type
- weight compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000007420 reactivation Effects 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42004502P | 2002-10-21 | 2002-10-21 | |
| SE0203105A SE0203105D0 (en) | 2002-10-21 | 2002-10-21 | Reactivation of wild type P53 in human tumour cells by a low molecular weight compound |
| SE0203105-2 | 2002-10-21 | ||
| US60/420,045 | 2002-10-21 | ||
| PCT/SE2003/001635 WO2004035580A1 (fr) | 2002-10-21 | 2003-10-21 | Reactivation de p53 de type sauvage dans des cellules tumorales humaines par un compose a faible poids moleculaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003272175A1 true AU2003272175A1 (en) | 2004-05-04 |
Family
ID=32109589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003272175A Abandoned AU2003272175A1 (en) | 2002-10-21 | 2003-10-21 | Reactivation of wild type p53 in human tumour cells by a low molecular weight compound |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003272175A1 (fr) |
| WO (1) | WO2004035580A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007139499A1 (fr) * | 2006-05-31 | 2007-12-06 | Aprea Ab | Composés pouvant être employés en tant que médicament |
| US7732447B2 (en) | 2006-06-22 | 2010-06-08 | Cephalon, Inc. | Fused [d]pyridazin-7-ones |
| UA107652C2 (en) * | 2008-10-06 | 2015-02-10 | Incuron Llc | Carbazole compounds and therapeutic uses of the compounds |
| EP2367821B1 (fr) | 2008-12-17 | 2015-09-16 | Merck Patent GmbH | Inhibiteurs de protéines kinases de type benzonaphtyridinones tricycliques modifiées sur le noyau c et leur utilisation |
| CN104981697B (zh) | 2013-02-11 | 2017-08-04 | 英丘伦有限责任公司 | 促染色质转录复合物(fact)在癌症中的用途 |
| CN104744340B (zh) * | 2013-12-30 | 2017-11-03 | 中国人民大学 | 多取代咔唑化合物及其制备方法与应用 |
| WO2015157172A1 (fr) | 2014-04-06 | 2015-10-15 | Incuron, Llc | Polythérapies à l'aide de curaxines |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| US9708333B2 (en) | 2015-08-12 | 2017-07-18 | Incyte Corporation | Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| CR20180516A (es) | 2016-03-28 | 2019-03-05 | Incyte Corp | Compuestos de iprrolotriazina como inhibidores de tam |
| CN106977515A (zh) * | 2017-04-13 | 2017-07-25 | 河北科技大学 | β‑咔啉、γ‑咔啉衍生物、其制备方法及用途 |
| SG11202002821UA (en) | 2017-09-27 | 2020-04-29 | Incyte Corp | Salts of pyrrolotriazine derivatives useful as tam inhibitors |
| CZ308104B6 (cs) * | 2018-03-12 | 2020-01-08 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. | Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití |
| PE20211805A1 (es) | 2018-06-29 | 2021-09-14 | Incyte Corp | Formulaciones de un inhibidor de axl/mer |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| CN114634521A (zh) * | 2020-12-15 | 2022-06-17 | 首药控股(北京)股份有限公司 | Dna-pk选择性抑制剂及其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2579208B1 (fr) * | 1985-03-22 | 1987-05-07 | Sanofi Sa | Nouveaux derives de le 5-h pyrido (3', 4' : 4,5) pyrrolo (3,2-c) pyridine, leur procede de preparation et leur activite antitumorale |
| FR2595701B1 (fr) * | 1986-03-17 | 1988-07-01 | Sanofi Sa | Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant |
| US4754038A (en) * | 1987-02-26 | 1988-06-28 | American Home Products Corporation | Carboline histamine H1 antagonists |
| RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
| EP1002535A1 (fr) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | Nouvelle utilisation des antagonistes du glutamate pour le traitement du cancer |
-
2003
- 2003-10-21 WO PCT/SE2003/001635 patent/WO2004035580A1/fr not_active Ceased
- 2003-10-21 AU AU2003272175A patent/AU2003272175A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004035580A1 (fr) | 2004-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |