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AU2003265864A1 - In vivo production of cyclic peptides for inhibiting protein-protein interaction - Google Patents

In vivo production of cyclic peptides for inhibiting protein-protein interaction

Info

Publication number
AU2003265864A1
AU2003265864A1 AU2003265864A AU2003265864A AU2003265864A1 AU 2003265864 A1 AU2003265864 A1 AU 2003265864A1 AU 2003265864 A AU2003265864 A AU 2003265864A AU 2003265864 A AU2003265864 A AU 2003265864A AU 2003265864 A1 AU2003265864 A1 AU 2003265864A1
Authority
AU
Australia
Prior art keywords
protein
cyclic peptides
vivo production
inhibiting
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003265864A
Other versions
AU2003265864A8 (en
Inventor
Mark K. Bennett
Todd M. Kinsella
James B. Lorens
Todd Pray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of AU2003265864A1 publication Critical patent/AU2003265864A1/en
Publication of AU2003265864A8 publication Critical patent/AU2003265864A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003265864A 2002-08-30 2003-08-30 In vivo production of cyclic peptides for inhibiting protein-protein interaction Abandoned AU2003265864A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23275802A 2002-08-30 2002-08-30
US10/232,758 2002-08-30
US10/422,536 2003-04-23
US10/422,536 US7252952B2 (en) 2000-03-06 2003-04-23 In vivo production of cyclic peptides for inhibiting protein—protein interaction
PCT/US2003/027371 WO2004019890A2 (en) 2002-08-30 2003-08-30 In vivo production of cyclic peptides for inhibiting protein-protein interaction

Publications (2)

Publication Number Publication Date
AU2003265864A1 true AU2003265864A1 (en) 2004-03-19
AU2003265864A8 AU2003265864A8 (en) 2004-03-19

Family

ID=31980961

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003265864A Abandoned AU2003265864A1 (en) 2002-08-30 2003-08-30 In vivo production of cyclic peptides for inhibiting protein-protein interaction

Country Status (4)

Country Link
US (1) US7252952B2 (en)
EP (1) EP1575553A4 (en)
AU (1) AU2003265864A1 (en)
WO (1) WO2004019890A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040091966A1 (en) * 1999-08-30 2004-05-13 Martin Zeidler Polypeptide regulation by conditional inteins
US7566765B2 (en) * 2000-03-06 2009-07-28 Rigel Pharmaceuticals, Inc. Heterocyclic compounds containing a nine-membered carbon-nitrogen ring
US7378248B2 (en) * 2000-03-06 2008-05-27 Rigel Pharmaceuticals, Inc. In vivo production of cyclic peptides for inhibiting protein-protein interaction
WO2002036738A2 (en) * 2000-10-30 2002-05-10 Kalobios, Inc. Affinity maturation by competitive selection
AU2003265865A1 (en) * 2002-08-30 2004-03-19 Rigel Pharmaceuticals, Inc. Methods of screening cyclic peptides and identifying targets therefor
US7745196B1 (en) 2004-03-25 2010-06-29 Rigel Pharmaceuticals, Inc. Methods and compositions for identifying peptide modulators of cell surface receptors
EP1749022A2 (en) * 2004-05-24 2007-02-07 Rigel Pharmaceuticals, Inc. Methods for cyclizing synthetic polymers
US20060009623A1 (en) * 2004-07-06 2006-01-12 National University Of Singapore C-terminal attachment of ligands to proteins for immobilization onto a support
US20060078875A1 (en) * 2004-09-23 2006-04-13 The Penn State Research Foundation Genetic selection of small molecule modulators of protein-protein interactions
US20060116316A1 (en) * 2004-10-14 2006-06-01 Kinsella Todd M Heterocyclic inhibitors of IRES-mediated translation and methods of use thereof
US20070026012A1 (en) * 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
WO2007024877A2 (en) * 2005-08-22 2007-03-01 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
WO2007103739A2 (en) * 2006-03-01 2007-09-13 The University Of Utah Research Foundation Methods and compositions related to cyclic peptide synthesis
US8470965B2 (en) * 2006-03-01 2013-06-25 University Of Utah Research Foundation Methods and compositions related to cyclic peptide synthesis
WO2008089132A2 (en) * 2007-01-12 2008-07-24 Cornell Research Foundation, Inc. Genetic selection for protein folding and solubility in the bacterial periplasm
RU2644335C2 (en) 2010-03-03 2018-02-08 Зе Юниверсити Оф Бритиш Коламбия Epitope, specific to amyloid beta oligomer and antibodies
JP6886816B2 (en) 2013-09-09 2021-06-16 カニムガイド セラピューティックス アーベー Immune system regulator
WO2015100277A2 (en) 2013-12-23 2015-07-02 University Of Rochester Methods and compositions for ribosomal synthesis of macrocyclic peptides
US12359192B2 (en) 2013-12-23 2025-07-15 University Of Rochester Methods and compositions for display of macrocyclic peptides
ES2853582T3 (en) 2015-03-06 2021-09-16 Canimguide Therapeutics Ab Immune system modulators and compositions
MX2018014366A (en) 2016-05-27 2019-04-11 Synthex Inc Protein interfaces.
WO2019104244A1 (en) 2017-11-22 2019-05-31 Synthex, Inc. Peptides for inhibiting rad51
CN111718417B (en) * 2019-03-19 2022-10-14 宁波鲲鹏生物科技有限公司 Fusion protein containing fluorescent protein fragment and application thereof
GB201909491D0 (en) * 2019-07-01 2019-08-14 Governing Council Of The Univ Of Toronto Detection of protein to protein interactions
AU2021392625A1 (en) * 2020-12-01 2023-07-06 Genentech, Inc. Biological vesicles displaying cell surface proteins and methods related to same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1295952A3 (en) * 1996-01-23 2003-07-09 The Board of Trustees of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
DE69930164T2 (en) 1998-12-18 2006-11-23 The Penn State Research Foundation INTEIN-MEDIATED CYCLISATION OF PEPTIDES
US6531316B1 (en) * 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
AU6045900A (en) * 1999-05-25 2000-12-12 Panorama Research, Inc. Interaction-activated proteins
WO2001055452A1 (en) * 2000-01-26 2001-08-02 Dana-Farber Cancer Institute, Inc. In vivo protein-protein interaction mapping
US7271256B2 (en) 2000-02-04 2007-09-18 New England Biolabs, Inc. Method for producing circular or multimeric protein species in vivo or in vitro and related methods
US7105341B2 (en) * 2000-03-06 2006-09-12 Rigel Pharmaceuticals. Inc. In vivo production of cyclic peptides
US6919184B2 (en) * 2000-04-03 2005-07-19 Rigel Pharmaceuticals, Inc. Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
US20030068649A1 (en) * 2000-09-14 2003-04-10 Doberstein Stephen K. Methods and compositions for the construction and use of fusion libraries
US20040053324A1 (en) * 2002-08-30 2004-03-18 Brian Wong Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents
US7723018B2 (en) * 2002-08-30 2010-05-25 Rigel Pharmaceuticals, Incorporated Methods of assaying for cell cycle modulators using components of the ubiquitin ligation cascade

Also Published As

Publication number Publication date
WO2004019890A3 (en) 2006-06-15
US20040014100A1 (en) 2004-01-22
US7252952B2 (en) 2007-08-07
AU2003265864A8 (en) 2004-03-19
EP1575553A2 (en) 2005-09-21
EP1575553A4 (en) 2008-07-30
WO2004019890A2 (en) 2004-03-11

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase