AU2003253197A1 - Targeted gene modification by single-stranded dna oligonucleotides - Google Patents

Targeted gene modification by single-stranded dna oligonucleotides

Info

Publication number: AU2003253197A1
Authority: AU; Australia
Prior art keywords: stranded dna; targeted gene; dna oligonucleotides; gene modification; modification
Prior art date: 2002-08-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2003253197A

Other versions

AU2003253197A8 (en

Inventor

Henricus Petrus Joseph Te Riele

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nederlands Kanker Instituut

Original Assignee

Nederlands Kanker Instituut

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-13

Filing date

2003-08-13

Publication date

2004-02-25

2003-08-13 Application filed by Nederlands Kanker Instituut filed Critical Nederlands Kanker Instituut

2004-02-25 Publication of AU2003253197A8 publication Critical patent/AU2003253197A8/en

2004-02-25 Publication of AU2003253197A1 publication Critical patent/AU2003253197A1/en

Status Abandoned legal-status Critical Current

Links

108020004414 DNA Proteins 0.000 title 1
102000053602 DNA Human genes 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 title 1
108020004682 Single-Stranded DNA Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
238000012239 gene modification Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination

Landscapes

Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Mycology (AREA)
Crystallography & Structural Chemistry (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AU2003253197A 2002-08-13 2003-08-13 Targeted gene modification by single-stranded dna oligonucleotides Abandoned AU2003253197A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0218803A GB0218803D0 (en)	2002-08-13	2002-08-13	Targeted gene modification by single-standed DNA oligonucleotides
GB0218803.5		2002-08-13
PCT/IB2003/003699 WO2004015117A2 (en)	2002-08-13	2003-08-13	Targeted gene modification by single-stranded dna oligonucleotides

Publications (2)

Publication Number	Publication Date
AU2003253197A8 AU2003253197A8 (en)	2004-02-25
AU2003253197A1 true AU2003253197A1 (en)	2004-02-25

Family

ID=9942224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2003253197A Abandoned AU2003253197A1 (en)	2002-08-13	2003-08-13	Targeted gene modification by single-stranded dna oligonucleotides

Country Status (3)

Country	Link
AU (1)	AU2003253197A1 (en)
GB (1)	GB0218803D0 (en)
WO (1)	WO2004015117A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011058555A1 (en)	2009-11-12	2011-05-19	Yeda Research And Development Co. Ltd.	A method of editing dna in a cell and constructs capable of same
WO2014102688A1 (en) *	2012-12-27	2014-07-03	Cellectis	New design matrix for improvement of homology-directed gene targeting
WO2018030536A1 (en) *	2016-08-12	2018-02-15	国立大学法人徳島大学	Genome editing method
WO2021186913A1 (en) *	2020-03-20	2021-09-23	国立大学法人筑波大学	Method for modifying methylated state of genomic dna
WO2022249775A1 (en) *	2021-05-27	2022-12-01	国立研究開発法人産業技術総合研究所	Genome editing method
WO2023190848A1 (en) *	2022-03-30	2023-10-05	国立研究開発法人産業技術総合研究所	Single-strand form polynucleotide and use thereof in genome editing

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990014092A1 (en) *	1989-05-18	1990-11-29	Cell Genesys, Inc.	Single-strand site-directed modification of mammalian genes in vivo
AU2515992A (en) *	1991-08-20	1993-03-16	Genpharm International, Inc.	Gene targeting in animal cells using isogenic dna constructs
EP0656747A4 (en) *	1992-08-21	1997-05-07	Univ California	COMPOSITION AND METHOD FOR CHANGING DNA SEQUENCES BY HOMOLOGOUS RECOMBINATION.
AU6328696A (en) *	1995-06-07	1996-12-30	Yale University	Treatment of hemoglobinopathies
EP0842289B1 (en) *	1995-07-26	2004-10-20	Mixis France S.A.	Homologous recombination in mismatch repair inactivated eukaryotic cells
CA2339420A1 (en) *	1998-08-12	2000-02-24	David Zarling	Domain specific gene evolution
US6271360B1 (en) *	1999-08-27	2001-08-07	Valigen (Us), Inc.	Single-stranded oligodeoxynucleotide mutational vectors
EP1152058A1 (en) *	2000-05-03	2001-11-07	Institut Curie	Methods and compositions for effecting homologous recombination
WO2002026967A2 (en) *	2000-09-25	2002-04-04	Thomas Jefferson University	Targeted gene correction by single-stranded oligodeoxynucleotides

2002
- 2002-08-13 GB GB0218803A patent/GB0218803D0/en not_active Ceased
2003
- 2003-08-13 WO PCT/IB2003/003699 patent/WO2004015117A2/en not_active Ceased
- 2003-08-13 AU AU2003253197A patent/AU2003253197A1/en not_active Abandoned

Also Published As

Publication number	Publication date
GB0218803D0 (en)	2002-09-18
AU2003253197A8 (en)	2004-02-25
WO2004015117A3 (en)	2004-06-03
WO2004015117A2 (en)	2004-02-19

Publication	Publication Date	Title
AU2003254334A1 (en)	2004-02-02	Rna-interference by single-stranded rna molecules
GB0318428D0 (en)	2003-09-10	Gene drivers
AU2003304094A1 (en)	2004-11-26	Nucleic acid sequence detection using multiplexed oligonucleotide pcr
AU2003290598A1 (en)	2004-06-03	Modified oligonucleotides for use in rna interference
AU2002345089A1 (en)	2003-05-22	Synthetic double stranded oligonucleotides for targeted inhibition of gene expression
EP1731525A4 (en)	2010-01-20	Nucleotide derivatives and dna microarray
WO2002026967A3 (en)	2003-01-09	Targeted gene correction by single-stranded oligodeoxynucleotides
EP1670944A4 (en)	2012-12-05	Microplates useful for conducting thermocycled nucleotide amplification
AU2003900368A0 (en)	2003-02-13	Assay for nucleic acid molecules
EP1633871A4 (en)	2010-02-17	Double-stranded nucleic acid
AU2003254597A1 (en)	2005-01-13	Dna chip based genetic typing
AU2003279509A8 (en)	2004-06-15	Targeted double stranded rna mediated cell killing
AU2003253197A1 (en)	2004-02-25	Targeted gene modification by single-stranded dna oligonucleotides
AU2003281867A1 (en)	2004-02-23	Antisense nucleic acids
EP1570074A4 (en)	2007-11-28	Genotyping of deafness by oligonucleotide microarray analysis
AU2003296087A1 (en)	2004-07-22	Nucleotide derivatives and dna microarray
AU2003285583A1 (en)	2004-06-30	Oligonucleotide guided analysis of gene expression
GB0508088D0 (en)	2005-06-01	Nucleic acid constructs for gene expression
AU2003245407A1 (en)	2003-12-22	Improvements for combinatorial oligonucleotide pcr
AU2003245575A1 (en)	2004-01-06	Oligonucleotide directed misfolding of rna
AU2003286495A1 (en)	2004-05-04	Rna-based inhibitory oligonucleotides
AU2001251208A1 (en)	2001-10-30	Gene inactivation by targeted dna methylation
HK1088638A (en)	2006-11-10	Dna chip based genetic typing
AU2003223619A1 (en)	2003-12-02	Antiviral phosphorothioate oligonucleotides
AU2003241850A1 (en)	2005-01-04	Multi-hybridization set for dna microarray related assay

Legal Events

Date	Code	Title	Description
2005-04-28	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase