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AU2003245700A1 - Pyrazolopyridine derivatives - Google Patents

Pyrazolopyridine derivatives

Info

Publication number
AU2003245700A1
AU2003245700A1 AU2003245700A AU2003245700A AU2003245700A1 AU 2003245700 A1 AU2003245700 A1 AU 2003245700A1 AU 2003245700 A AU2003245700 A AU 2003245700A AU 2003245700 A AU2003245700 A AU 2003245700A AU 2003245700 A1 AU2003245700 A1 AU 2003245700A1
Authority
AU
Australia
Prior art keywords
pyrazolopyridine derivatives
pyrazolopyridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003245700A
Inventor
Jason Witherington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0203295A external-priority patent/GB0203295D0/en
Priority claimed from GB0206610A external-priority patent/GB0206610D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2003245700A1 publication Critical patent/AU2003245700A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003245700A 2002-02-12 2003-02-12 Pyrazolopyridine derivatives Abandoned AU2003245700A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0203295.1 2002-02-12
GB0203295A GB0203295D0 (en) 2002-02-12 2002-02-12 Novel method and compounds
GB0206610A GB0206610D0 (en) 2002-03-20 2002-03-20 Novel compounds
GB0206610.8 2002-03-20
PCT/GB2003/000576 WO2003068773A1 (en) 2002-02-12 2003-02-12 Pyrazolopyridine derivatives

Publications (1)

Publication Number Publication Date
AU2003245700A1 true AU2003245700A1 (en) 2003-09-04

Family

ID=27736199

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003245700A Abandoned AU2003245700A1 (en) 2002-02-12 2003-02-12 Pyrazolopyridine derivatives

Country Status (2)

Country Link
AU (1) AU2003245700A1 (en)
WO (1) WO2003068773A1 (en)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN112313232A (en) * 2018-05-02 2021-02-02 Jw中外制药公司 Novel heterocyclic derivatives

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JP2006504755A (en) * 2002-10-15 2006-02-09 スミスクライン ビーチャム コーポレーション Pyridazine compounds as GSK-3 inhibitors
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ES2214150B1 (en) * 2003-02-27 2005-12-01 J. URIACH & CIA S.A. "NEW DERIVATIVES OF PIRAZOLOPIRIDINAS".
ES2214976B1 (en) * 2003-03-14 2005-12-16 J. URIACH & CIA S.A. "NEW DERIVATIVES OF PIRAZOLOPIRIDINAS".
DE102004005172A1 (en) * 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazole derivatives as inhibitors of the hormone sensitive lipase
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING MEN WITH METABOLIC AND ANTHROPOMETRIC DISORDERS
ES2241496B1 (en) * 2004-04-15 2006-12-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDINA.
US7626021B2 (en) 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
EP1778687A2 (en) * 2004-07-27 2007-05-02 SGX Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
JP2008508303A (en) 2004-07-27 2008-03-21 エスジーエックス ファーマシューティカルズ、インコーポレイテッド Pyrrolo-pyridine kinase modulator
AR050188A1 (en) * 2004-08-03 2006-10-04 Uriach Y Compania S A J CONDENSED HETEROCICLIC COMPOUNDS USED IN THERAPY AS INHIBITORS OF P38 KINASES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR20160058972A (en) * 2004-09-02 2016-05-25 제넨테크, 인크. Pyridyl inhibitors of hedgehog signalling
BRPI0612320A2 (en) * 2005-06-27 2010-11-09 Sanofi Aventis pyrazolopyridine derivatives as beta-adrenergic kinase 1 receptor inhibitors
ES2270715B1 (en) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. NEW DERIVATIVES OF PIRAZINA.
FR2889526B1 (en) * 2005-08-04 2012-02-17 Aventis Pharma Sa SUBSTITUTED 7-AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
ES2274712B1 (en) * 2005-10-06 2008-03-01 Laboratorios Almirall S.A. NEW IMIDAZOPIRIDINE DERIVATIVES.
JP2009512711A (en) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Regulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2007219509A1 (en) * 2006-01-18 2007-09-07 Siena Biotech S.P.A Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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EP1870410A1 (en) * 2006-06-13 2007-12-26 Bayer Schering Pharma Aktiengesellschaft Substituted arylpyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2303776B1 (en) * 2006-12-29 2009-08-07 Laboratorios Almirall S.A. DERIVATIVES OF 5-PHENYL-6-PIRIDIN-4-IL-1,3-DIHIDRO-2H-IMIDAZO (4,5-B) PIRIDIN-2-ONA USEFUL AS ANTAGONISTS OF ADENOSINE A2B RECEIVER.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101790532B (en) * 2007-07-31 2013-11-20 沃泰克斯药物股份有限公司 Preparation method of 5-fluoro-1H-pyrazolo [3,4-b ] pyridine-3-amine and derivatives thereof
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EP2070929A1 (en) 2007-12-11 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
PL2222675T3 (en) 2007-12-19 2014-02-28 Genentech Inc 5-anilinoimidazopyridines and methods of use
KR20100122505A (en) 2008-02-29 2010-11-22 어레이 바이오파마 인크. Raf inhibitor compounds and methods of use thereof
WO2009111279A1 (en) 2008-02-29 2009-09-11 Array Biopharma Inc. Pyrazole [3, 4-b] pyridine raf inhibitors
WO2010016846A1 (en) * 2008-08-08 2010-02-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
WO2010027114A1 (en) * 2008-09-05 2010-03-11 Choongwae Pharma Corporation Use of pyrazole-pyridine derivatives and its salts for treating or reventin osteoporosis
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2470532A1 (en) * 2009-08-28 2012-07-04 Array Biopharma, Inc. 1h-pyrazolo [ 3, 4-b]pyridine compounds for inhibiting raf kinase
FR2951172B1 (en) * 2009-10-13 2014-09-26 Pf Medicament PYRAZOLOPYRIDINE DERIVATIVES AS ANTI-CANCER AGENT
EP2491033A4 (en) * 2009-10-20 2013-03-13 Eiger Biopharmaceuticals Inc Azaindazoles to treat flaviviridae virus infection
US8487102B2 (en) * 2010-04-20 2013-07-16 Hoffmann-La Roche Inc. Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR20120063283A (en) * 2010-12-07 2012-06-15 제일약품주식회사 Novel pyrazolopyridine derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same
FR2970967B1 (en) * 2011-01-27 2013-02-15 Pf Medicament AZAINDAZOLE OR DIAZAINDAZOLE DERIVATIVES AS A MEDICINAL PRODUCT
EP2797888B1 (en) 2011-12-31 2016-06-08 BeiGene, Ltd. Fused tricyclic compounds as raf kinase inhibitors
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2014206344A1 (en) 2013-06-28 2014-12-31 Beigene, Ltd. Fused tricyclic amide compounds as multiple kinase inhibitors
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
KR102022866B1 (en) * 2014-08-19 2019-09-19 상하이 하이헤 파마수티컬 컴퍼니 리미티드 Indazole compounds as fgfr kinase inhibitor, preparation and use thereof
CN106279119B (en) * 2015-05-27 2020-06-16 上海海和药物研究开发有限公司 Preparation and application of novel kinase inhibitor
KR101753654B1 (en) 2015-10-21 2017-07-05 한국화학연구원 Novel 3-(4-(piperazin-1-yl)benzamido)-1H-pyrazolopyridine derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating MELK(maternal embryonic leucine zipper kinase) activity related diseases containing the same as an active ingredient
WO2020010092A1 (en) * 2018-07-03 2020-01-09 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
JP2022520671A (en) 2019-02-08 2022-03-31 フリークエンシー・セラピューティクス・インコーポレイテッド Valproic acid compounds and WNT agonists for the treatment of ear disorders
US11773121B2 (en) * 2020-01-30 2023-10-03 Virovax Llc Antiviral compounds
CN111303118B (en) * 2020-02-17 2021-11-09 清华大学 Compounds and their use in the treatment of hepatitis B
CN117529475A (en) 2021-01-08 2024-02-06 艾福姆德尤股份有限公司 Heterobicyclic compounds containing urea or analogues and compounds thereof for the treatment of diseases associated with STING activity
KR102580387B1 (en) * 2021-05-07 2023-09-19 한국화학연구원 Pharmaceutical compositions comprising novel pyrazolo[3,4-b]pyridine derivatives for preventing or treating metabolic diseases including obesity and diabetes mellitus, or nonalcholic steatohepatitis
WO2023018781A1 (en) * 2021-08-10 2023-02-16 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity

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WO2002050073A1 (en) * 2000-12-19 2002-06-27 Smithkline Beecham P.L.C. Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112313232A (en) * 2018-05-02 2021-02-02 Jw中外制药公司 Novel heterocyclic derivatives
CN112313232B (en) * 2018-05-02 2024-03-08 Jw中外制药公司 New heterocyclic derivatives

Also Published As

Publication number Publication date
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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase