AU2002324323A2 - Casein derived peptides and uses thereof in therapy - Google Patents

Casein derived peptides and uses thereof in therapy Download PDF

Info

Publication number: AU2002324323A2
Authority: AU; Australia
Prior art keywords: peptide; casein; pharmaceutical composition; derived; terminus portion
Prior art date: 2001-08-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2002324323A

Other languages

English (en)

Inventor

Zvi Sidelman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Peptera Pharmaceuticals Ltd

Original Assignee

Peptera Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-30

Filing date

2002-08-29

Publication date

2003-03-10

2001-08-30 Priority claimed from US09/942,121 external-priority patent/US20020147144A1/en

2002-08-29 Application filed by Peptera Pharmaceuticals Ltd filed Critical Peptera Pharmaceuticals Ltd

2003-03-10 Publication of AU2002324323A2 publication Critical patent/AU2002324323A2/en

2006-09-28 Assigned to PEPTERA PARMACEUTICALS LTD. reassignment PEPTERA PARMACEUTICALS LTD. Request for Assignment Assignors: CHAY 13 MEDICAL RESEARCH GROUP N.V.

Status Abandoned legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims description 908
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 title claims description 621
235000021240 caseins Nutrition 0.000 title claims description 621
239000005018 casein Substances 0.000 title claims description 620
102000004196 processed proteins & peptides Human genes 0.000 title description 152
238000002560 therapeutic procedure Methods 0.000 title description 5
239000008194 pharmaceutical composition Substances 0.000 claims description 495
238000000034 method Methods 0.000 claims description 310
239000003937 drug carrier Substances 0.000 claims description 244
239000004480 active ingredient Substances 0.000 claims description 238
230000001939 inductive effect Effects 0.000 claims description 164
102000036693 Thrombopoietin Human genes 0.000 claims description 120
108010041111 Thrombopoietin Proteins 0.000 claims description 120
210000000130 stem cell Anatomy 0.000 claims description 89
239000012634 fragment Substances 0.000 claims description 77
238000013467 fragmentation Methods 0.000 claims description 74
238000006062 fragmentation reaction Methods 0.000 claims description 74
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 72
210000004369 blood Anatomy 0.000 claims description 69
239000008280 blood Substances 0.000 claims description 69
238000002360 preparation method Methods 0.000 claims description 69
230000004663 cell proliferation Effects 0.000 claims description 67
239000003814 drug Substances 0.000 claims description 61
210000003958 hematopoietic stem cell Anatomy 0.000 claims description 53
241000282414 Homo sapiens Species 0.000 claims description 50
210000001772 blood platelet Anatomy 0.000 claims description 50
230000002708 enhancing effect Effects 0.000 claims description 49
230000007812 deficiency Effects 0.000 claims description 46
210000001185 bone marrow Anatomy 0.000 claims description 42
206010043554 thrombocytopenia Diseases 0.000 claims description 42
238000011282 treatment Methods 0.000 claims description 42
201000010099 disease Diseases 0.000 claims description 41
230000035755 proliferation Effects 0.000 claims description 36
230000000694 effects Effects 0.000 claims description 35
206010033661 Pancytopenia Diseases 0.000 claims description 32
201000010000 Agranulocytosis Diseases 0.000 claims description 31
206010018687 Granulocytopenia Diseases 0.000 claims description 31
208000035475 disorder Diseases 0.000 claims description 31
238000010322 bone marrow transplantation Methods 0.000 claims description 30
210000002540 macrophage Anatomy 0.000 claims description 28
210000005259 peripheral blood Anatomy 0.000 claims description 28
239000011886 peripheral blood Substances 0.000 claims description 28
210000004180 plasmocyte Anatomy 0.000 claims description 28
230000011132 hemopoiesis Effects 0.000 claims description 26
208000023275 Autoimmune disease Diseases 0.000 claims description 23
206010012601 diabetes mellitus Diseases 0.000 claims description 23
230000003612 virological effect Effects 0.000 claims description 23
206010018473 Glycosuria Diseases 0.000 claims description 22
241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 21
208000036142 Viral infection Diseases 0.000 claims description 21
230000004069 differentiation Effects 0.000 claims description 21
230000035780 glucosuria Effects 0.000 claims description 21
230000009385 viral infection Effects 0.000 claims description 21
208000030507 AIDS Diseases 0.000 claims description 20
208000031226 Hyperlipidaemia Diseases 0.000 claims description 19
210000004698 lymphocyte Anatomy 0.000 claims description 19
230000010437 erythropoiesis Effects 0.000 claims description 18
208000015181 infectious disease Diseases 0.000 claims description 17
230000003190 augmentative effect Effects 0.000 claims description 16
241000725303 Human immunodeficiency virus Species 0.000 claims description 15
238000002512 chemotherapy Methods 0.000 claims description 15
210000004443 dendritic cell Anatomy 0.000 claims description 15
208000014951 hematologic disease Diseases 0.000 claims description 15
125000003275 alpha amino acid group Chemical group 0.000 claims description 14
210000000440 neutrophil Anatomy 0.000 claims description 14
230000002093 peripheral effect Effects 0.000 claims description 14
230000000735 allogeneic effect Effects 0.000 claims description 13
230000002489 hematologic effect Effects 0.000 claims description 13
208000018706 hematopoietic system disease Diseases 0.000 claims description 13
230000001400 myeloablative effect Effects 0.000 claims description 13
238000011127 radiochemotherapy Methods 0.000 claims description 13
108090000394 Erythropoietin Proteins 0.000 claims description 12
102000003951 Erythropoietin Human genes 0.000 claims description 12
210000001787 dendrite Anatomy 0.000 claims description 12
229940105423 erythropoietin Drugs 0.000 claims description 12
208000026278 immune system disease Diseases 0.000 claims description 12
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 12
238000011476 stem cell transplantation Methods 0.000 claims description 12
208000035150 Hypercholesterolemia Diseases 0.000 claims description 11
201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 11
101100005297 Mus musculus Cat gene Proteins 0.000 claims description 8
208000032467 Aplastic anaemia Diseases 0.000 claims description 7
238000001959 radiotherapy Methods 0.000 claims description 7
208000035143 Bacterial infection Diseases 0.000 claims description 6
208000037913 T-cell disorder Diseases 0.000 claims description 6
208000022362 bacterial infectious disease Diseases 0.000 claims description 6
210000002443 helper t lymphocyte Anatomy 0.000 claims description 6
201000001421 hyperglycemia Diseases 0.000 claims description 6
238000002054 transplantation Methods 0.000 claims description 3
101150064066 CTSL gene Proteins 0.000 claims description 2
239000004615 ingredient Substances 0.000 claims 7
101150053100 cls1 gene Proteins 0.000 claims 1
102000011632 Caseins Human genes 0.000 description 407
108010076119 Caseins Proteins 0.000 description 407
210000004027 cell Anatomy 0.000 description 103
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 35
235000001014 amino acid Nutrition 0.000 description 29
229940024606 amino acid Drugs 0.000 description 28
150000001413 amino acids Chemical class 0.000 description 27
239000000203 mixture Substances 0.000 description 23
241000699670 Mus sp. Species 0.000 description 20
210000003593 megakaryocyte Anatomy 0.000 description 18
239000004471 Glycine Substances 0.000 description 17
230000000638 stimulation Effects 0.000 description 17
238000003556 assay Methods 0.000 description 16
238000011534 incubation Methods 0.000 description 16
210000002798 bone marrow cell Anatomy 0.000 description 14
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 14
102000004127 Cytokines Human genes 0.000 description 13
108090000695 Cytokines Proteins 0.000 description 13
238000002347 injection Methods 0.000 description 13
239000007924 injection Substances 0.000 description 13
238000004519 manufacturing process Methods 0.000 description 12
239000002609 medium Substances 0.000 description 12
208000031886 HIV Infections Diseases 0.000 description 10
239000000427 antigen Substances 0.000 description 10
102000036639 antigens Human genes 0.000 description 10
108091007433 antigens Proteins 0.000 description 10
239000000725 suspension Substances 0.000 description 10
210000003743 erythrocyte Anatomy 0.000 description 9
210000004700 fetal blood Anatomy 0.000 description 9
238000010348 incorporation Methods 0.000 description 9
230000001965 increasing effect Effects 0.000 description 9
230000001225 therapeutic effect Effects 0.000 description 9
206010028980 Neoplasm Diseases 0.000 description 8
201000011510 cancer Diseases 0.000 description 8
239000012636 effector Substances 0.000 description 8
239000003102 growth factor Substances 0.000 description 8
229940090044 injection Drugs 0.000 description 8
230000004048 modification Effects 0.000 description 8
238000012986 modification Methods 0.000 description 8
230000002265 prevention Effects 0.000 description 8
241001529936 Murinae Species 0.000 description 7
239000012980 RPMI-1640 medium Substances 0.000 description 7
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 7
239000002253 acid Substances 0.000 description 7
239000003795 chemical substances by application Substances 0.000 description 7
210000000265 leukocyte Anatomy 0.000 description 7
239000000546 pharmaceutical excipient Substances 0.000 description 7
239000000243 solution Substances 0.000 description 7
229940104230 thymidine Drugs 0.000 description 7
102100037904 CD9 antigen Human genes 0.000 description 6
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
108010010803 Gelatin Proteins 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
229920002472 Starch Polymers 0.000 description 6
210000001744 T-lymphocyte Anatomy 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 6
238000004113 cell culture Methods 0.000 description 6
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
150000001875 compounds Chemical class 0.000 description 6
235000013365 dairy product Nutrition 0.000 description 6
239000010432 diamond Substances 0.000 description 6
230000000925 erythroid effect Effects 0.000 description 6
238000009472 formulation Methods 0.000 description 6
229920000159 gelatin Polymers 0.000 description 6
239000008273 gelatin Substances 0.000 description 6
235000019322 gelatine Nutrition 0.000 description 6
235000011852 gelatine desserts Nutrition 0.000 description 6
210000003714 granulocyte Anatomy 0.000 description 6
230000003394 haemopoietic effect Effects 0.000 description 6
238000004128 high performance liquid chromatography Methods 0.000 description 6
210000005260 human cell Anatomy 0.000 description 6
230000004044 response Effects 0.000 description 6
-1 triangles Chemical compound 0.000 description 6
108091003079 Bovine Serum Albumin Proteins 0.000 description 5
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 5
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 5
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
230000004071 biological effect Effects 0.000 description 5
210000000601 blood cell Anatomy 0.000 description 5
239000002775 capsule Substances 0.000 description 5
239000000969 carrier Substances 0.000 description 5
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 5
230000028993 immune response Effects 0.000 description 5
235000013336 milk Nutrition 0.000 description 5
239000008267 milk Substances 0.000 description 5
210000004080 milk Anatomy 0.000 description 5
229920001223 polyethylene glycol Polymers 0.000 description 5
238000007363 ring formation reaction Methods 0.000 description 5
235000019698 starch Nutrition 0.000 description 5
235000000346 sugar Nutrition 0.000 description 5
210000001519 tissue Anatomy 0.000 description 5
241000283690 Bos taurus Species 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
241000283707 Capra Species 0.000 description 4
108090000746 Chymosin Proteins 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
102000014171 Milk Proteins Human genes 0.000 description 4
108010011756 Milk Proteins Proteins 0.000 description 4
241000283973 Oryctolagus cuniculus Species 0.000 description 4
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
235000010980 cellulose Nutrition 0.000 description 4
239000012228 culture supernatant Substances 0.000 description 4
239000008298 dragée Substances 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
239000007788 liquid Substances 0.000 description 4
229960001913 mecysteine Drugs 0.000 description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
239000001267 polyvinylpyrrolidone Substances 0.000 description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
239000000843 powder Substances 0.000 description 4
235000018102 proteins Nutrition 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
239000000523 sample Substances 0.000 description 4
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
239000003381 stabilizer Substances 0.000 description 4
230000004936 stimulating effect Effects 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000003826 tablet Substances 0.000 description 4
FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 description 3
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
208000034423 Delivery Diseases 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 3
229920001917 Ficoll Polymers 0.000 description 3
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 3
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 3
241000282412 Homo Species 0.000 description 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
241000699666 Mus <mouse, genus> Species 0.000 description 3
208000033776 Myeloid Acute Leukemia Diseases 0.000 description 3
241001494479 Pecora Species 0.000 description 3
102000003992 Peroxidases Human genes 0.000 description 3
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
238000004820 blood count Methods 0.000 description 3
229910002092 carbon dioxide Inorganic materials 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
210000001072 colon Anatomy 0.000 description 3
230000009089 cytolysis Effects 0.000 description 3
238000001514 detection method Methods 0.000 description 3
238000011161 development Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
230000029087 digestion Effects 0.000 description 3
239000002552 dosage form Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
229940088598 enzyme Drugs 0.000 description 3
239000012091 fetal bovine serum Substances 0.000 description 3
235000013305 food Nutrition 0.000 description 3
230000006870 function Effects 0.000 description 3
239000000499 gel Substances 0.000 description 3
239000008103 glucose Substances 0.000 description 3
238000007446 glucose tolerance test Methods 0.000 description 3
238000003306 harvesting Methods 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
238000010255 intramuscular injection Methods 0.000 description 3
239000007927 intramuscular injection Substances 0.000 description 3
238000007912 intraperitoneal administration Methods 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
239000008101 lactose Substances 0.000 description 3
230000000670 limiting effect Effects 0.000 description 3
229930182817 methionine Natural products 0.000 description 3
229920000609 methyl cellulose Polymers 0.000 description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
239000001923 methylcellulose Substances 0.000 description 3
235000010981 methylcellulose Nutrition 0.000 description 3
235000021239 milk protein Nutrition 0.000 description 3
210000005087 mononuclear cell Anatomy 0.000 description 3
210000000822 natural killer cell Anatomy 0.000 description 3
231100000252 nontoxic Toxicity 0.000 description 3
230000003000 nontoxic effect Effects 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
108040007629 peroxidase activity proteins Proteins 0.000 description 3
239000012071 phase Substances 0.000 description 3
239000002243 precursor Substances 0.000 description 3
238000012545 processing Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
230000002062 proliferating effect Effects 0.000 description 3
238000011160 research Methods 0.000 description 3
239000000600 sorbitol Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
238000006467 substitution reaction Methods 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
238000012360 testing method Methods 0.000 description 3
231100000419 toxicity Toxicity 0.000 description 3
230000001988 toxicity Effects 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
CWLQUGTUXBXTLF-RXMQYKEDSA-N (2r)-1-methylpyrrolidine-2-carboxylic acid Chemical compound CN1CCC[C@@H]1C(O)=O CWLQUGTUXBXTLF-RXMQYKEDSA-N 0.000 description 2
AKCRVYNORCOYQT-RXMQYKEDSA-N (2r)-3-methyl-2-(methylazaniumyl)butanoate Chemical compound C[NH2+][C@H](C(C)C)C([O-])=O AKCRVYNORCOYQT-RXMQYKEDSA-N 0.000 description 2
NPDBDJFLKKQMCM-SCSAIBSYSA-N (2s)-2-amino-3,3-dimethylbutanoic acid Chemical compound CC(C)(C)[C@H](N)C(O)=O NPDBDJFLKKQMCM-SCSAIBSYSA-N 0.000 description 2
AXDLCFOOGCNDST-VIFPVBQESA-N (2s)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid Chemical compound CN[C@H](C(O)=O)CC1=CC=C(O)C=C1 AXDLCFOOGCNDST-VIFPVBQESA-N 0.000 description 2
FOUZISDNESEYLX-UHFFFAOYSA-N 2-(2-hydroxyethylazaniumyl)acetate Chemical compound OCCNCC(O)=O FOUZISDNESEYLX-UHFFFAOYSA-N 0.000 description 2
OYIFNHCXNCRBQI-UHFFFAOYSA-N 2-aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 description 2
GAUBNQMYYJLWNF-UHFFFAOYSA-N 3-(Carboxymethylamino)propanoic acid Chemical compound OC(=O)CCNCC(O)=O GAUBNQMYYJLWNF-UHFFFAOYSA-N 0.000 description 2
AOKCDAVWJLOAHG-UHFFFAOYSA-N 4-(methylamino)butyric acid Chemical compound C[NH2+]CCCC([O-])=O AOKCDAVWJLOAHG-UHFFFAOYSA-N 0.000 description 2
208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
229920001817 Agar Polymers 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
241000282836 Camelus dromedarius Species 0.000 description 2
CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 2
238000002965 ELISA Methods 0.000 description 2
102000008946 Fibrinogen Human genes 0.000 description 2
108010049003 Fibrinogen Proteins 0.000 description 2
102000016359 Fibronectins Human genes 0.000 description 2
108010067306 Fibronectins Proteins 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
208000037357 HIV infectious disease Diseases 0.000 description 2
102000008100 Human Serum Albumin Human genes 0.000 description 2
108091006905 Human Serum Albumin Proteins 0.000 description 2
SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 2
QWCKQJZIFLGMSD-VKHMYHEASA-N L-alpha-aminobutyric acid Chemical compound CC[C@H](N)C(O)=O QWCKQJZIFLGMSD-VKHMYHEASA-N 0.000 description 2
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
108010007622 LDL Lipoproteins Proteins 0.000 description 2
102000007330 LDL Lipoproteins Human genes 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
101100494762 Mus musculus Nedd9 gene Proteins 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
108010077895 Sarcosine Proteins 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
241000282898 Sus scrofa Species 0.000 description 2
230000006052 T cell proliferation Effects 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
206010047700 Vomiting Diseases 0.000 description 2
102100023038 WD and tetratricopeptide repeats protein 1 Human genes 0.000 description 2
239000000443 aerosol Substances 0.000 description 2
239000008272 agar Substances 0.000 description 2
235000010419 agar Nutrition 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
238000011316 allogeneic transplantation Methods 0.000 description 2
230000003321 amplification Effects 0.000 description 2
238000010171 animal model Methods 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
230000006907 apoptotic process Effects 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000000975 bioactive effect Effects 0.000 description 2
210000003995 blood forming stem cell Anatomy 0.000 description 2
239000000872 buffer Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
229910000389 calcium phosphate Inorganic materials 0.000 description 2
235000011010 calcium phosphates Nutrition 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
150000007942 carboxylates Chemical class 0.000 description 2
230000024245 cell differentiation Effects 0.000 description 2
230000032823 cell division Effects 0.000 description 2
230000008859 change Effects 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
229940107161 cholesterol Drugs 0.000 description 2
229940080701 chymosin Drugs 0.000 description 2
238000000576 coating method Methods 0.000 description 2
230000005757 colony formation Effects 0.000 description 2
239000003636 conditioned culture medium Substances 0.000 description 2
239000000470 constituent Substances 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
230000001066 destructive effect Effects 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000010685 fatty oil Substances 0.000 description 2
239000012894 fetal calf serum Substances 0.000 description 2
229940012952 fibrinogen Drugs 0.000 description 2
239000000945 filler Substances 0.000 description 2
238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
230000037406 food intake Effects 0.000 description 2
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
239000008187 granular material Substances 0.000 description 2
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 2
238000010166 immunofluorescence Methods 0.000 description 2
230000006698 induction Effects 0.000 description 2
230000003993 interaction Effects 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000002372 labelling Methods 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
231100000518 lethal Toxicity 0.000 description 2
230000001665 lethal effect Effects 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
238000004949 mass spectrometry Methods 0.000 description 2
210000001616 monocyte Anatomy 0.000 description 2
210000002894 multi-fate stem cell Anatomy 0.000 description 2
GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 2
XJODGRWDFZVTKW-ZCFIWIBFSA-N n-methylleucine Chemical compound CN[C@@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-ZCFIWIBFSA-N 0.000 description 2
238000010899 nucleation Methods 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
230000007170 pathology Effects 0.000 description 2
239000000816 peptidomimetic Substances 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
238000002616 plasmapheresis Methods 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
230000008569 process Effects 0.000 description 2
230000002797 proteolythic effect Effects 0.000 description 2
230000006337 proteolytic cleavage Effects 0.000 description 2
230000005855 radiation Effects 0.000 description 2
230000002285 radioactive effect Effects 0.000 description 2
238000000926 separation method Methods 0.000 description 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
239000007787 solid Substances 0.000 description 2
208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
230000003319 supportive effect Effects 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
239000000454 talc Substances 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
235000012222 talc Nutrition 0.000 description 2
239000010936 titanium Substances 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
230000035899 viability Effects 0.000 description 2
230000008673 vomiting Effects 0.000 description 2
XLBVNMSMFQMKEY-SCSAIBSYSA-N (2r)-2-(methylamino)pentanedioic acid Chemical compound CN[C@@H](C(O)=O)CCC(O)=O XLBVNMSMFQMKEY-SCSAIBSYSA-N 0.000 description 1
SCIFESDRCALIIM-SECBINFHSA-N (2r)-2-(methylazaniumyl)-3-phenylpropanoate Chemical compound CN[C@@H](C(O)=O)CC1=CC=CC=C1 SCIFESDRCALIIM-SECBINFHSA-N 0.000 description 1
CYZKJBZEIFWZSR-ZCFIWIBFSA-N (2r)-3-(1h-imidazol-5-yl)-2-(methylamino)propanoic acid Chemical compound CN[C@@H](C(O)=O)CC1=CN=CN1 CYZKJBZEIFWZSR-ZCFIWIBFSA-N 0.000 description 1
CZCIKBSVHDNIDH-LLVKDONJSA-N (2r)-3-(1h-indol-3-yl)-2-(methylamino)propanoic acid Chemical compound C1=CC=C2C(C[C@@H](NC)C(O)=O)=CNC2=C1 CZCIKBSVHDNIDH-LLVKDONJSA-N 0.000 description 1
KSZFSNZOGAXEGH-SCSAIBSYSA-N (2r)-5-amino-2-(methylamino)-5-oxopentanoic acid Chemical compound CN[C@@H](C(O)=O)CCC(N)=O KSZFSNZOGAXEGH-SCSAIBSYSA-N 0.000 description 1
OZRWQPFBXDVLAH-RXMQYKEDSA-N (2r)-5-amino-2-(methylamino)pentanoic acid Chemical compound CN[C@@H](C(O)=O)CCCN OZRWQPFBXDVLAH-RXMQYKEDSA-N 0.000 description 1
BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 description 1
LDUWTIUXPVCEQF-LURJTMIESA-N (2s)-2-(cyclopentylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC1CCCC1 LDUWTIUXPVCEQF-LURJTMIESA-N 0.000 description 1
LDQAVQLJHUEMEY-JTQLQIEISA-N (2s)-2-(ethylamino)-3-(4-hydroxyphenyl)propanoic acid Chemical compound CCN[C@H](C(O)=O)CC1=CC=C(O)C=C1 LDQAVQLJHUEMEY-JTQLQIEISA-N 0.000 description 1
NVXKJPGRZSDYPK-JTQLQIEISA-N (2s)-2-(methylamino)-4-phenylbutanoic acid Chemical compound CN[C@H](C(O)=O)CCC1=CC=CC=C1 NVXKJPGRZSDYPK-JTQLQIEISA-N 0.000 description 1
HOKKHZGPKSLGJE-VKHMYHEASA-N (2s)-2-(methylamino)butanedioic acid Chemical compound CN[C@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-VKHMYHEASA-N 0.000 description 1
FPDYKABXINADKS-LURJTMIESA-N (2s)-2-(methylazaniumyl)hexanoate Chemical compound CCCC[C@H](NC)C(O)=O FPDYKABXINADKS-LURJTMIESA-N 0.000 description 1
HCPKYUNZBPVCHC-YFKPBYRVSA-N (2s)-2-(methylazaniumyl)pentanoate Chemical compound CCC[C@H](NC)C(O)=O HCPKYUNZBPVCHC-YFKPBYRVSA-N 0.000 description 1
WTDHSXGBDZBWAW-QMMMGPOBSA-N (2s)-2-[cyclohexyl(methyl)azaniumyl]propanoate Chemical compound OC(=O)[C@H](C)N(C)C1CCCCC1 WTDHSXGBDZBWAW-QMMMGPOBSA-N 0.000 description 1
KWWFNGCKGYUCLC-RXMQYKEDSA-N (2s)-3,3-dimethyl-2-(methylamino)butanoic acid Chemical compound CN[C@H](C(O)=O)C(C)(C)C KWWFNGCKGYUCLC-RXMQYKEDSA-N 0.000 description 1
XKZCXMNMUMGDJG-AWEZNQCLSA-N (2s)-3-[(6-acetylnaphthalen-2-yl)amino]-2-aminopropanoic acid Chemical compound C1=C(NC[C@H](N)C(O)=O)C=CC2=CC(C(=O)C)=CC=C21 XKZCXMNMUMGDJG-AWEZNQCLSA-N 0.000 description 1
LNSMPSPTFDIWRQ-VKHMYHEASA-N (2s)-4-amino-2-(methylamino)-4-oxobutanoic acid Chemical compound CN[C@H](C(O)=O)CC(N)=O LNSMPSPTFDIWRQ-VKHMYHEASA-N 0.000 description 1
XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 description 1
RHMALYOXPBRJBG-WXHCCQJTSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s,3r)-2-[[(2s)-2-[[2-[[2-[[(2r)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]- Chemical compound C([C@@H](C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 RHMALYOXPBRJBG-WXHCCQJTSA-N 0.000 description 1
FMNQRUKVXAQEAZ-JNRFBPFXSA-N (5z,8s,9r,10e,12s)-9,12-dihydroxy-8-[(1s)-1-hydroxy-3-oxopropyl]heptadeca-5,10-dienoic acid Chemical compound CCCCC[C@H](O)\C=C\[C@@H](O)[C@H]([C@@H](O)CC=O)C\C=C/CCCC(O)=O FMNQRUKVXAQEAZ-JNRFBPFXSA-N 0.000 description 1
DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
XCDGCRLSSSSBIA-UHFFFAOYSA-N 2-(2-methylsulfanylethylamino)acetic acid Chemical compound CSCCNCC(O)=O XCDGCRLSSSSBIA-UHFFFAOYSA-N 0.000 description 1
DHGYLUFLENKZHH-UHFFFAOYSA-N 2-(3-aminopropylamino)acetic acid Chemical compound NCCCNCC(O)=O DHGYLUFLENKZHH-UHFFFAOYSA-N 0.000 description 1
KGSVNOLLROCJQM-UHFFFAOYSA-N 2-(benzylamino)acetic acid Chemical compound OC(=O)CNCC1=CC=CC=C1 KGSVNOLLROCJQM-UHFFFAOYSA-N 0.000 description 1
KQLGGQARRCMYGD-UHFFFAOYSA-N 2-(cyclobutylamino)acetic acid Chemical compound OC(=O)CNC1CCC1 KQLGGQARRCMYGD-UHFFFAOYSA-N 0.000 description 1
DICMQVOBSKLBBN-UHFFFAOYSA-N 2-(cyclodecylamino)acetic acid Chemical compound OC(=O)CNC1CCCCCCCCC1 DICMQVOBSKLBBN-UHFFFAOYSA-N 0.000 description 1
NPLBBQAAYSJEMO-UHFFFAOYSA-N 2-(cycloheptylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCCCC1 NPLBBQAAYSJEMO-UHFFFAOYSA-N 0.000 description 1
OQMYZVWIXPPDDE-UHFFFAOYSA-N 2-(cyclohexylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCCC1 OQMYZVWIXPPDDE-UHFFFAOYSA-N 0.000 description 1
PNKNDNFLQNMQJL-UHFFFAOYSA-N 2-(cyclooctylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCCCCC1 PNKNDNFLQNMQJL-UHFFFAOYSA-N 0.000 description 1
DXQCCQKRNWMECV-UHFFFAOYSA-N 2-(cyclopropylazaniumyl)acetate Chemical compound OC(=O)CNC1CC1 DXQCCQKRNWMECV-UHFFFAOYSA-N 0.000 description 1
AWEZYTUWDZADKR-UHFFFAOYSA-N 2-[(2-amino-2-oxoethyl)azaniumyl]acetate Chemical compound NC(=O)CNCC(O)=O AWEZYTUWDZADKR-UHFFFAOYSA-N 0.000 description 1
DZNLECPWHICWPP-UHFFFAOYSA-N 2-[2-(1h-imidazol-2-yl)ethylamino]acetic acid Chemical compound OC(=O)CNCCC1=NC=CN1 DZNLECPWHICWPP-UHFFFAOYSA-N 0.000 description 1
HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
101800000535 3C-like proteinase Proteins 0.000 description 1
101800002396 3C-like proteinase nsp5 Proteins 0.000 description 1
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
229940124718 AIDS vaccine Drugs 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
108091005508 Acid proteases Proteins 0.000 description 1
208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
206010002068 Anaemia neonatal Diseases 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
206010006002 Bone pain Diseases 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
241000282826 Camelus Species 0.000 description 1
241000283705 Capra hircus Species 0.000 description 1
101710132601 Capsid protein Proteins 0.000 description 1
241000282994 Cervidae Species 0.000 description 1
241000283153 Cetacea Species 0.000 description 1
VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
206010009944 Colon cancer Diseases 0.000 description 1
206010010356 Congenital anomaly Diseases 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
108010069514 Cyclic Peptides Proteins 0.000 description 1
102000001189 Cyclic Peptides Human genes 0.000 description 1
LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 1
XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 description 1
AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 description 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 description 1
229930028154 D-arginine Natural products 0.000 description 1
HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 description 1
229930195721 D-histidine Natural products 0.000 description 1
229930182845 D-isoleucine Natural products 0.000 description 1
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 description 1
229930182819 D-leucine Natural products 0.000 description 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 description 1
229930182818 D-methionine Natural products 0.000 description 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 description 1
229930182832 D-phenylalanine Natural products 0.000 description 1
229930182820 D-proline Natural products 0.000 description 1
229930182827 D-tryptophan Natural products 0.000 description 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 1
OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 description 1
229930195709 D-tyrosine Natural products 0.000 description 1
KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 description 1
229930182831 D-valine Natural products 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
239000004338 Dichlorodifluoromethane Substances 0.000 description 1
229930195710 D‐cysteine Natural products 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
241000792859 Enema Species 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 description 1
108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
102000015779 HDL Lipoproteins Human genes 0.000 description 1
108010010234 HDL Lipoproteins Proteins 0.000 description 1
206010062713 Haemorrhagic diathesis Diseases 0.000 description 1
239000012981 Hank's balanced salt solution Substances 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
208000032843 Hemorrhage Diseases 0.000 description 1
206010019663 Hepatic failure Diseases 0.000 description 1
101001033279 Homo sapiens Interleukin-3 Proteins 0.000 description 1
101001076408 Homo sapiens Interleukin-6 Proteins 0.000 description 1
101000946053 Homo sapiens Lysosomal-associated transmembrane protein 4A Proteins 0.000 description 1
101000766306 Homo sapiens Serotransferrin Proteins 0.000 description 1
101000799461 Homo sapiens Thrombopoietin Proteins 0.000 description 1
101000694103 Homo sapiens Thyroid peroxidase Proteins 0.000 description 1
LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
208000001911 Idiopathic aplastic anemia Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
108010002386 Interleukin-3 Proteins 0.000 description 1
102000000646 Interleukin-3 Human genes 0.000 description 1
108090001007 Interleukin-8 Proteins 0.000 description 1
239000007760 Iscove's Modified Dulbecco's Medium Substances 0.000 description 1
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
150000008575 L-amino acids Chemical class 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
JTTHKOPSMAVJFE-VIFPVBQESA-N L-homophenylalanine Chemical compound OC(=O)[C@@H](N)CCC1=CC=CC=C1 JTTHKOPSMAVJFE-VIFPVBQESA-N 0.000 description 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
206010025323 Lymphomas Diseases 0.000 description 1
102100034728 Lysosomal-associated transmembrane protein 4A Human genes 0.000 description 1
241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
235000019759 Maize starch Nutrition 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
CYZKJBZEIFWZSR-LURJTMIESA-N N(alpha)-methyl-L-histidine Chemical compound CN[C@H](C(O)=O)CC1=CNC=N1 CYZKJBZEIFWZSR-LURJTMIESA-N 0.000 description 1
CZCIKBSVHDNIDH-NSHDSACASA-N N(alpha)-methyl-L-tryptophan Chemical compound C1=CC=C2C(C[C@H]([NH2+]C)C([O-])=O)=CNC2=C1 CZCIKBSVHDNIDH-NSHDSACASA-N 0.000 description 1
WRUZLCLJULHLEY-UHFFFAOYSA-N N-(p-hydroxyphenyl)glycine Chemical compound OC(=O)CNC1=CC=C(O)C=C1 WRUZLCLJULHLEY-UHFFFAOYSA-N 0.000 description 1
VKZGJEWGVNFKPE-UHFFFAOYSA-N N-Isobutylglycine Chemical compound CC(C)CNCC(O)=O VKZGJEWGVNFKPE-UHFFFAOYSA-N 0.000 description 1
SCIFESDRCALIIM-UHFFFAOYSA-N N-Me-Phenylalanine Natural products CNC(C(O)=O)CC1=CC=CC=C1 SCIFESDRCALIIM-UHFFFAOYSA-N 0.000 description 1
XLBVNMSMFQMKEY-BYPYZUCNSA-N N-methyl-L-glutamic acid Chemical compound CN[C@H](C(O)=O)CCC(O)=O XLBVNMSMFQMKEY-BYPYZUCNSA-N 0.000 description 1
YAXAFCHJCYILRU-YFKPBYRVSA-N N-methyl-L-methionine Chemical compound C[NH2+][C@H](C([O-])=O)CCSC YAXAFCHJCYILRU-YFKPBYRVSA-N 0.000 description 1
SCIFESDRCALIIM-VIFPVBQESA-N N-methyl-L-phenylalanine Chemical compound C[NH2+][C@H](C([O-])=O)CC1=CC=CC=C1 SCIFESDRCALIIM-VIFPVBQESA-N 0.000 description 1
AKCRVYNORCOYQT-YFKPBYRVSA-N N-methyl-L-valine Chemical compound CN[C@@H](C(C)C)C(O)=O AKCRVYNORCOYQT-YFKPBYRVSA-N 0.000 description 1
CWLQUGTUXBXTLF-YFKPBYRVSA-N N-methylproline Chemical compound CN1CCC[C@H]1C(O)=O CWLQUGTUXBXTLF-YFKPBYRVSA-N 0.000 description 1
101150054880 NASP gene Proteins 0.000 description 1
206010058116 Nephrogenic anaemia Diseases 0.000 description 1
BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
238000006610 Payne rearrangement reaction Methods 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108010033276 Peptide Fragments Proteins 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
108010043958 Peptoids Proteins 0.000 description 1
102000015795 Platelet Membrane Glycoproteins Human genes 0.000 description 1
108010010336 Platelet Membrane Glycoproteins Proteins 0.000 description 1
208000013544 Platelet disease Diseases 0.000 description 1
208000002151 Pleural effusion Diseases 0.000 description 1
208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
102100034195 Thrombopoietin Human genes 0.000 description 1
XNRNNGPBEPRNAR-UHFFFAOYSA-N Thromboxane B2 Natural products CCCCCC(O)C=CC1OC(O)CC(O)C1CC=CCCCC(O)=O XNRNNGPBEPRNAR-UHFFFAOYSA-N 0.000 description 1
101710113649 Thyroid peroxidase Proteins 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
WEVYAHXRMPXWCK-UHFFFAOYSA-N acetonitrile Substances CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
201000004208 acquired thrombocytopenia Diseases 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
229940040563 agaric acid Drugs 0.000 description 1
239000000556 agonist Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
DLAMVQGYEVKIRE-UHFFFAOYSA-N alpha-(methylamino)isobutyric acid Chemical compound CNC(C)(C)C(O)=O DLAMVQGYEVKIRE-UHFFFAOYSA-N 0.000 description 1
238000010976 amide bond formation reaction Methods 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
229940067621 aminobutyrate Drugs 0.000 description 1
229940124277 aminobutyric acid Drugs 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
201000000975 anemia of prematurity Diseases 0.000 description 1
230000002744 anti-aggregatory effect Effects 0.000 description 1
230000036436 anti-hiv Effects 0.000 description 1
230000003276 anti-hypertensive effect Effects 0.000 description 1
239000003173 antianemic agent Substances 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
239000003443 antiviral agent Substances 0.000 description 1
239000008135 aqueous vehicle Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
238000003149 assay kit Methods 0.000 description 1
239000012911 assay medium Substances 0.000 description 1
230000000923 atherogenic effect Effects 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
239000004305 biphenyl Substances 0.000 description 1
208000034158 bleeding Diseases 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000010836 blood and blood product Substances 0.000 description 1
230000036765 blood level Effects 0.000 description 1
229940125691 blood product Drugs 0.000 description 1
230000037396 body weight Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
244000309464 bull Species 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
229960005069 calcium Drugs 0.000 description 1
235000001465 calcium Nutrition 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229960004424 carbon dioxide Drugs 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
229940021722 caseins Drugs 0.000 description 1
230000003915 cell function Effects 0.000 description 1
230000007910 cell fusion Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
208000029742 colonic neoplasm Diseases 0.000 description 1
235000021277 colostrum Nutrition 0.000 description 1
210000003022 colostrum Anatomy 0.000 description 1
239000000306 component Substances 0.000 description 1
238000004624 confocal microscopy Methods 0.000 description 1
235000020247 cow milk Nutrition 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
210000004748 cultured cell Anatomy 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
230000000120 cytopathologic effect Effects 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000034994 death Effects 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000004040 defense response to microbe Effects 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
238000012217 deletion Methods 0.000 description 1
230000037430 deletion Effects 0.000 description 1
YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
229950006137 dexfosfoserine Drugs 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
229940042935 dichlorodifluoromethane Drugs 0.000 description 1
235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
238000009510 drug design Methods 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
230000003028 elevating effect Effects 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
239000007920 enema Substances 0.000 description 1
229940079360 enema for constipation Drugs 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
210000000267 erythroid cell Anatomy 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
230000005284 excitation Effects 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical class O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
239000011888 foil Substances 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
229940093181 glucose injection Drugs 0.000 description 1
230000004153 glucose metabolism Effects 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
230000002641 glycemic effect Effects 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
238000000227 grinding Methods 0.000 description 1
230000012010 growth Effects 0.000 description 1
230000010005 growth-factor like effect Effects 0.000 description 1
208000031169 hemorrhagic disease Diseases 0.000 description 1
230000002008 hemorrhagic effect Effects 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
102000053400 human TPO Human genes 0.000 description 1
229940116886 human interleukin-6 Drugs 0.000 description 1
235000020256 human milk Nutrition 0.000 description 1
210000004251 human milk Anatomy 0.000 description 1
QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
229960002591 hydroxyproline Drugs 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 1
230000002519 immonomodulatory effect Effects 0.000 description 1
208000003669 immune deficiency disease Diseases 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
230000001506 immunosuppresive effect Effects 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000031891 intestinal absorption Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
238000007914 intraventricular administration Methods 0.000 description 1
230000007794 irritation Effects 0.000 description 1
RGXCTRIQQODGIZ-UHFFFAOYSA-O isodesmosine Chemical compound OC(=O)C(N)CCCC[N+]1=CC(CCC(N)C(O)=O)=CC(CCC(N)C(O)=O)=C1CCCC(N)C(O)=O RGXCTRIQQODGIZ-UHFFFAOYSA-O 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
POPBCYBNIJKVES-XAFWQQJMSA-N isracidin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C1=CN=CN1 POPBCYBNIJKVES-XAFWQQJMSA-N 0.000 description 1
230000000366 juvenile effect Effects 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
239000002502 liposome Substances 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
208000007903 liver failure Diseases 0.000 description 1
231100000835 liver failure Toxicity 0.000 description 1
244000144972 livestock Species 0.000 description 1
238000011068 loading method Methods 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
210000003141 lower extremity Anatomy 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000008176 lyophilized powder Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000007257 malfunction Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
108010032806 molgramostim Proteins 0.000 description 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
210000004898 n-terminal fragment Anatomy 0.000 description 1
230000031942 natural killer cell mediated cytotoxicity Effects 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
239000002547 new drug Substances 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
210000004940 nucleus Anatomy 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
238000011275 oncology therapy Methods 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000003791 organic solvent mixture Substances 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
150000002926 oxygen Chemical class 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
230000003071 parasitic effect Effects 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
208000008494 pericarditis Diseases 0.000 description 1
BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000003075 phytoestrogen Substances 0.000 description 1
108010086662 phytohemagglutinin-M Proteins 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
238000007747 plating Methods 0.000 description 1
208000008423 pleurisy Diseases 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000000955 prescription drug Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000000135 prohibitive effect Effects 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000009877 rendering Methods 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000009919 sequestration Effects 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000012439 solid excipient Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000007801 sublethal irradiation Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000012134 supernatant fraction Substances 0.000 description 1
230000009469 supplementation Effects 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
229920002397 thermoplastic olefin Polymers 0.000 description 1
229940035024 thioglycerol Drugs 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
230000035921 thrombopoiesis Effects 0.000 description 1
230000001361 thrombopoietic effect Effects 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
229960004319 trichloroacetic acid Drugs 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
235000002374 tyrosine Nutrition 0.000 description 1
229960004441 tyrosine Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
229940045136 urea Drugs 0.000 description 1
229940116269 uric acid Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
235000008939 whole milk Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Zoology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Marine Sciences & Fisheries (AREA)
AIDS & HIV (AREA)
Emergency Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AU2002324323A 2001-08-30 2002-08-29 Casein derived peptides and uses thereof in therapy Abandoned AU2002324323A2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/942,121		2001-08-30
US09/942,121 US20020147144A1 (en)	2000-03-01	2001-08-30	Casein derived peptides and uses thereof in therapy
PCT/IL2002/000720 WO2003018606A2 (fr)	2001-08-30	2002-08-29	Peptides derives de la caseine et leurs utilisations therapeutiques

Publications (1)

Publication Number	Publication Date
AU2002324323A2 true AU2002324323A2 (en)	2003-03-10

Family

ID=25477603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2002324323A Abandoned AU2002324323A2 (en)	2001-08-30	2002-08-29	Casein derived peptides and uses thereof in therapy

Country Status (15)

Country	Link
EP (1)	EP1556074A4 (fr)
JP (1)	JP2005511499A (fr)
KR (1)	KR20040078639A (fr)
CN (1)	CN1694719A (fr)
AU (1)	AU2002324323A2 (fr)
BR (1)	BR0212625A (fr)
CA (1)	CA2458924A1 (fr)
CZ (1)	CZ2004335A3 (fr)
HU (1)	HUP0500995A3 (fr)
IL (1)	IL160548A0 (fr)
MX (1)	MXPA04001890A (fr)
NO (1)	NO20040880L (fr)
PL (1)	PL375113A1 (fr)
WO (1)	WO2003018606A2 (fr)
ZA (1)	ZA200401574B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0313892D0 (en) *	2003-06-16	2003-07-23	Hannah Res Inst	Control of lactation
JP2007525214A (ja) *	2004-01-30	2007-09-06	ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド	Ｎ−アセチルトランスフェラーゼ遺伝子型解析によって投与するナフタルイミド
AU2005215943A1 (en) *	2004-03-01	2005-09-09	Peptera Pharmaceutical Ltd.	Casein derived peptides and therapeutic uses thereof
GB0423352D0 (en) *	2004-10-21	2004-11-24	Hannah Res Inst	"Control of mammary cell number"
ES2319475B1 (es) *	2005-06-08	2010-02-16	Consejo Superior Investig. Cientificas	Peptidos bioactivos identificados en hidrolizados enzimaticos de caseinas lacteas y procedimiento de obtencion.
JP4394155B2 (ja) *	2006-06-09	2010-01-06	森永乳業株式会社	脂質代謝改善剤
JP2011026213A (ja) *	2009-07-22	2011-02-10	Snow Brand Milk Prod Co Ltd	１型糖尿病抑制ペプチド
AU2013249522A1 (en) *	2012-04-16	2014-10-30	The Cleveland Clinic Foundation	Multivalent breast cancer vaccine
US20190381128A1 (en) *	2017-03-03	2019-12-19	Morinaga Milk Industry Co., Ltd.	GLP-1 Secretagogue and Composition
CN107814835B (zh) *	2017-12-01	2020-04-28	熊猫乳品集团股份有限公司	一种生物活性多肽avpitptlnreq及其制备方法和应用
CN108017709B (zh) *	2017-12-12	2020-04-10	浙江辉肽生命健康科技有限公司	一种生物活性多肽kepmigvnqela及其制备方法和应用
CN113952446B (zh) *	2021-09-03	2023-12-05	河南省医药科学研究院	生物活性肽在抑制骨髓毒性中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3778426A (en) *	1970-12-16	1973-12-11	Research Corp	Therapeutically useful polypeptides
US6150547A (en) *	1997-03-21	2000-11-21	Snow Brand Milk Products Co., Ltd.	Iron-casein complex hydrolyzate and process for the production thereof
IL134830A0 (en) *	2000-03-01	2001-05-20	Chay 13 Medical Res Group N V	Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them

2002
- 2002-08-29 EP EP02758768A patent/EP1556074A4/fr not_active Withdrawn
- 2002-08-29 HU HU0500995A patent/HUP0500995A3/hu unknown
- 2002-08-29 MX MXPA04001890A patent/MXPA04001890A/es not_active Application Discontinuation
- 2002-08-29 AU AU2002324323A patent/AU2002324323A2/en not_active Abandoned
- 2002-08-29 JP JP2003523265A patent/JP2005511499A/ja active Pending
- 2002-08-29 WO PCT/IL2002/000720 patent/WO2003018606A2/fr not_active Ceased
- 2002-08-29 BR BRPI0212625-7A patent/BR0212625A/pt not_active IP Right Cessation
- 2002-08-29 CZ CZ2004335A patent/CZ2004335A3/cs unknown
- 2002-08-29 IL IL16054802A patent/IL160548A0/xx unknown
- 2002-08-29 KR KR10-2004-7002884A patent/KR20040078639A/ko not_active Withdrawn
- 2002-08-29 CA CA002458924A patent/CA2458924A1/fr not_active Abandoned
- 2002-08-29 PL PL02375113A patent/PL375113A1/xx not_active Application Discontinuation
- 2002-08-29 CN CNA028216741A patent/CN1694719A/zh active Pending
2004
- 2004-02-26 ZA ZA200401574A patent/ZA200401574B/en unknown
- 2004-02-27 NO NO20040880A patent/NO20040880L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20040078639A (ko)	2004-09-10
HUP0500995A3 (en)	2008-09-29
HUP0500995A2 (en)	2007-05-02
EP1556074A2 (fr)	2005-07-27
MXPA04001890A (es)	2004-06-18
CA2458924A1 (fr)	2003-03-06
BR0212625A (pt)	2007-06-19
ZA200401574B (en)	2007-02-28
EP1556074A4 (fr)	2008-05-07
PL375113A1 (en)	2005-11-28
NO20040880L (no)	2004-04-20
IL160548A0 (en)	2004-07-25
CN1694719A (zh)	2005-11-09
WO2003018606A3 (fr)	2005-05-06
WO2003018606A9 (fr)	2004-04-08
WO2003018606A2 (fr)	2003-03-06
JP2005511499A (ja)	2005-04-28
CZ2004335A3 (cs)	2004-07-14

Publication	Publication Date	Title
AU782662B2 (en)	2005-08-18	Casein derived peptides and uses thereof in therapy
US20070203060A1 (en)	2007-08-30	Casein Derived Peptides And Therapeutic Uses Thereof
US7666996B2 (en)	2010-02-23	Casein derived peptides and uses thereof
ES2246566T3 (es)	2006-02-16	Aplicacion de proteinas hsp70.
AU2002324323A2 (en)	2003-03-10	Casein derived peptides and uses thereof in therapy
US12115207B2 (en)	2024-10-15	Treatment of inflammation

Legal Events

Date	Code	Title	Description
2004-05-06	DA3	Amendments made section 104	Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 29 MAR 2004
2006-09-28	PC1	Assignment before grant (sect. 113)	Owner name: PEPTERA PARMACEUTICALS LTD. Free format text: FORMER APPLICANT(S): CHAY 13 MEDICAL RESEARCH GROUP N.V.
2006-10-19	TH	Corrigenda	Free format text: IN VOL 20, NO 37, PAGE(S) 3607 UNDER THE HEADING ASSIGNMENTS BEFORE GRANT, SECTION 113 - 2002 UNDERTHE NAME PEPTERA PARMACEUTICALS, APPLICATION NO. 2002324323, UNDER INID (71), CORRECT TO READ PEPTERA PHARMACEUTICALS
2009-05-14	MK5	Application lapsed section 142(2)(e) - patent request and compl. specification not accepted