[go: up one dir, main page]

AU2002306736A1 - A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same - Google Patents

A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same

Info

Publication number
AU2002306736A1
AU2002306736A1 AU2002306736A AU2002306736A AU2002306736A1 AU 2002306736 A1 AU2002306736 A1 AU 2002306736A1 AU 2002306736 A AU2002306736 A AU 2002306736A AU 2002306736 A AU2002306736 A AU 2002306736A AU 2002306736 A1 AU2002306736 A1 AU 2002306736A1
Authority
AU
Australia
Prior art keywords
immunogenicity
replication
delivery
same
linking antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002306736A
Inventor
Chien-Fu Hung
Tzyy-Choou Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of AU2002306736A1 publication Critical patent/AU2002306736A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002306736A 2001-03-16 2002-03-18 A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same Abandoned AU2002306736A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27685401P 2001-03-16 2001-03-16
US60/276,854 2001-03-16
PCT/US2002/008033 WO2002074920A2 (en) 2001-03-16 2002-03-18 A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same

Publications (1)

Publication Number Publication Date
AU2002306736A1 true AU2002306736A1 (en) 2002-10-03

Family

ID=23058342

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002306736A Abandoned AU2002306736A1 (en) 2001-03-16 2002-03-18 A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same

Country Status (2)

Country Link
AU (1) AU2002306736A1 (en)
WO (1) WO2002074920A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8128922B2 (en) 1999-10-20 2012-03-06 Johns Hopkins University Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
US7342002B2 (en) 2000-08-03 2008-03-11 The Johns Hopkins University Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen
JP5089847B2 (en) 2001-03-27 2012-12-05 ニューヨーク・ユニバーシティ Treatment of tumors using alphavirus-based high affinity laminin receptor targeting vector
WO2004098526A2 (en) 2003-05-05 2004-11-18 Johns Hopkins University Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
US7910093B2 (en) 2003-08-19 2011-03-22 New York University Method for detecting cancer cells and monitoring cancer therapy
CA2594040A1 (en) 2005-01-06 2006-07-13 The Johns Hopkins University Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines
US7303898B2 (en) 2005-03-29 2007-12-04 New York University Defective sindbis viral vectors
US9085638B2 (en) 2007-03-07 2015-07-21 The Johns Hopkins University DNA vaccine enhancement with MHC class II activators
CN101036784B (en) * 2007-03-09 2010-11-10 中国人民解放军第二军医大学 Toxicity T cell position vaccine of the cell for treating Hepatitis B and the preparing method
EP2591114B1 (en) * 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
BR112013000244A2 (en) 2010-07-06 2016-05-17 Novartis Ag lipid liposomes having advantageous pka for administration of rna
DK3243526T3 (en) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa SUPPLY OF RNA TO TRACT MULTIPLE IMMUNE SIGNAL WAYS
RS63315B1 (en) 2010-08-31 2022-07-29 Glaxosmithkline Biologicals Sa PEGYLATED LIPOSOMES FOR THE DELIVERY OF IMMUNOGENE-ENCODING RNA
CA2814386C (en) 2010-10-11 2019-08-20 Novartis Ag Antigen delivery platforms
EP3310368B1 (en) 2015-06-19 2025-07-16 LGC Clinical Diagnostics, Inc. Sindbis control virus
CN111836639A (en) * 2018-01-26 2020-10-27 河谷细胞有限公司 Compositions and methods for combination cancer vaccines and immune adjuvant therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792462A (en) * 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
US6017735A (en) * 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses

Also Published As

Publication number Publication date
WO2002074920A2 (en) 2002-09-26
WO2002074920A3 (en) 2003-09-25

Similar Documents

Publication Publication Date Title
AU2003235707A1 (en) Immunogenic preparations and vaccines on the basis of mrna
AU2002306736A1 (en) A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same
AU7089600A (en) Monoclonal antibodies and vaccines against epitopes on the ebola virus glycoprotein
AU2003221704A1 (en) Immunogenic peptides, and method of identifying same
ZA200201816B (en) A vaccine composition and method of using the same.
AU2002323484A1 (en) Insulin related transcription factor and uses thereof
AU2003270149A1 (en) Akap18 delta, a novel splicing variant of a protein kinase a anchor protein and the use of the same
AU2002255649A1 (en) Band 3 antigenic peptides, malaria polypeptides and uses thereof
AU2002305028A1 (en) West nile virus epitopes and uses thereof
AU2002228347A1 (en) Malaria plasmodium antigen polypeptide SE36, method of purifying the same and vaccine and diagnostic with the use of the thus obtained antigen
AU2001269640A1 (en) Vaccine against the influenza virus and method for producing said virus vaccine
AU2002212049A1 (en) Novel silicone material, its preparation method and the use thereof
WO2004058188A3 (en) Vaccine compositions and methods
AU2002312373A1 (en) Structural and cytoskeleton-associated proteins
AU5851296A (en) Malaria peptides and vaccines
AU2001236817A1 (en) Insulin homolog polypeptide zins4
AU2002325783A1 (en) Vaccine formulation potentiated by the combination of a DNA and an antigen
AU5502499A (en) A new gene of human lysoenzyme, the encoding polypeptide and methods for preparing them
AU2002364340A1 (en) High-porosity materials and method for preparing same
AU2002321852A1 (en) Recombinant polypeptide for immunocastration and vaccine comprising the same
AU2002259099A1 (en) Immunogenic tumor antigens: nucleic acids and polypeptides encoding the same and methods of use thereof
AU2002320621A1 (en) Structural and cytoskeleton-associated proteins
AU2002221553A1 (en) Vaccines containing recombinant hantavirus proteins, methods for producing said vaccines and their use
AU2003240866A1 (en) Antibodies, peptides and vaccines against hiv-1 virus
AU2003260608A1 (en) Method of preparing recombinant mononegaviruses and the applications thereof

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase