AU2002349295A1 - Glucose dependant release of insulin from glucose sensing insulin derivatives - Google Patents
Glucose dependant release of insulin from glucose sensing insulin derivativesInfo
- Publication number
- AU2002349295A1 AU2002349295A1 AU2002349295A AU2002349295A AU2002349295A1 AU 2002349295 A1 AU2002349295 A1 AU 2002349295A1 AU 2002349295 A AU2002349295 A AU 2002349295A AU 2002349295 A AU2002349295 A AU 2002349295A AU 2002349295 A1 AU2002349295 A1 AU 2002349295A1
- Authority
- AU
- Australia
- Prior art keywords
- glucose
- insulin
- derivatives
- dependant release
- sensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title 2
- 239000008103 glucose Substances 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101784 | 2001-12-02 | ||
| DKPA200101784 | 2001-12-02 | ||
| US33703301P | 2001-12-05 | 2001-12-05 | |
| US60/337,033 | 2001-12-05 | ||
| PCT/DK2002/000804 WO2003048195A2 (en) | 2001-12-02 | 2002-12-02 | Glucose dependant release of insulin from glucose sensing insulin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002349295A1 true AU2002349295A1 (en) | 2003-06-17 |
| AU2002349295A8 AU2002349295A8 (en) | 2003-06-17 |
Family
ID=26069103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002349295A Abandoned AU2002349295A1 (en) | 2001-12-02 | 2002-12-02 | Glucose dependant release of insulin from glucose sensing insulin derivatives |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1453860A2 (en) |
| JP (1) | JP2005526009A (en) |
| AU (1) | AU2002349295A1 (en) |
| WO (1) | WO2003048195A2 (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1539244A1 (en) * | 2002-06-27 | 2005-06-15 | Novo Nordisk A/S | Use of dimethyl sulfone as isotonicity agent |
| DE602007009496D1 (en) | 2006-02-27 | 2010-11-11 | Novo Nordisk As | INSULIN DERIVATIVES |
| ES2601839T3 (en) | 2006-09-22 | 2017-02-16 | Novo Nordisk A/S | Protease resistant insulin analogs |
| JP5496082B2 (en) | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー／エス | Method for drying protein composition, dry protein composition, and pharmaceutical composition containing dry protein |
| EP2254905B1 (en) | 2008-03-14 | 2016-12-14 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| DK2254906T3 (en) | 2008-03-18 | 2017-01-23 | Novo Nordisk As | Protease-stabilized acylated insulin analogues |
| KR101635689B1 (en) * | 2009-01-28 | 2016-07-01 | 스마트쎌스, 인크. | Conjugate based systems for controlled drug delivery |
| WO2011000823A1 (en) | 2009-06-30 | 2011-01-06 | Novo Nordisk A/S | Insulin derivatives |
| EP2348360B1 (en) * | 2010-01-25 | 2017-09-27 | Rohm and Haas Electronic Materials LLC | Photoresist comprising nitrogen-containing compound |
| CN104010652A (en) * | 2011-10-27 | 2014-08-27 | 卡斯西部储备大学 | Ultra-concentrated rapid-acting insulin analogue formulations |
| CA2870313A1 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
| US9867869B2 (en) | 2012-12-12 | 2018-01-16 | Massachusetts Institute Of Technology | Insulin derivatives for diabetes treatment |
| US10376644B2 (en) | 2013-04-05 | 2019-08-13 | Novo Nordisk A/S | Dose logging device for a drug delivery device |
| AU2014333979B2 (en) | 2013-10-07 | 2018-02-15 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| AR099569A1 (en) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE |
| KR102677852B1 (en) * | 2015-03-13 | 2024-06-25 | 케이스 웨스턴 리저브 유니버시티 | Insulin analogues containing glucose-controlled conformational transitions |
| EP3291828A4 (en) | 2015-05-06 | 2018-10-03 | Alborz Mahdavi | Glucose responsive insulins |
| CN109562185A (en) | 2016-06-02 | 2019-04-02 | 赛诺菲 | The new conjugate of medicament and the part that albumen can be incuded in conjunction with glucose |
| TW201831504A (en) * | 2016-11-21 | 2018-09-01 | 美國凱斯西方瑞瑟夫大學 | Fast-acting insulin analogue with enhanced stability |
| WO2018106696A1 (en) | 2016-12-05 | 2018-06-14 | North Carolina State University | Core-shell microneedle devices and uses thereof |
| HUE060149T2 (en) | 2016-12-16 | 2023-02-28 | Novo Nordisk As | Insulin containing pharmaceutical compositions |
| EP3707145B1 (en) | 2017-11-09 | 2023-06-21 | Novo Nordisk A/S | Glucose-sensitive albumin-binding derivatives |
| KR20200095507A (en) | 2017-12-01 | 2020-08-10 | 사노피 | A novel conjugate of a drug and a moiety capable of binding to a glucose sensing protein |
| CN112423741A (en) * | 2018-04-16 | 2021-02-26 | 犹他大学研究基金会 | Glucose-responsive insulin |
| EP3946363A2 (en) * | 2019-03-29 | 2022-02-09 | Novo Nordisk A/S | Glucose sensitive insulin derivatives |
| JP2022543586A (en) * | 2019-07-31 | 2022-10-13 | サーマリン インコーポレイテッド | Insulin analogues with glucose-regulated conformational switches |
| AU2021247169A1 (en) * | 2020-03-31 | 2022-10-20 | Protomer Technologies Inc. | Conjugates for selective responsiveness to vicinal diols |
| TW202237188A (en) * | 2020-11-19 | 2022-10-01 | 美商普羅托莫科技公司 | Aromatic boron-containing compounds and insulin analogs |
| JPWO2022154055A1 (en) * | 2021-01-13 | 2022-07-21 | ||
| KR20250005573A (en) | 2022-05-18 | 2025-01-09 | 프로토머 테크놀로지스 인크. | Aromatic boron-containing compounds and related insulin analogs |
| JP7634756B2 (en) * | 2023-04-24 | 2025-02-21 | ノヴォ ノルディスク アー／エス | Glucose-sensitive insulin derivatives |
| CN121127486A (en) * | 2023-04-24 | 2025-12-12 | 诺和诺德股份有限公司 | Glucose-sensitive insulin derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2027930C (en) * | 1989-10-19 | 1998-06-30 | Tsuyoshi Miyazaki | Polymer complexes of a sugar response type |
| JP2002543092A (en) * | 1999-04-27 | 2002-12-17 | イーライ・リリー・アンド・カンパニー | Insulin crystals for pulmonary administration |
| WO2001092334A1 (en) * | 2000-06-02 | 2001-12-06 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
-
2002
- 2002-12-02 WO PCT/DK2002/000804 patent/WO2003048195A2/en not_active Ceased
- 2002-12-02 AU AU2002349295A patent/AU2002349295A1/en not_active Abandoned
- 2002-12-02 EP EP02781167A patent/EP1453860A2/en not_active Withdrawn
- 2002-12-02 JP JP2003549382A patent/JP2005526009A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005526009A (en) | 2005-09-02 |
| EP1453860A2 (en) | 2004-09-08 |
| WO2003048195A3 (en) | 2004-03-25 |
| AU2002349295A8 (en) | 2003-06-17 |
| WO2003048195A2 (en) | 2003-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |