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AU2002222343A1 - Methods for identifying inhibitors of ubiquitin-mediated proteolysis of ikb - Google Patents

Methods for identifying inhibitors of ubiquitin-mediated proteolysis of ikb

Info

Publication number
AU2002222343A1
AU2002222343A1 AU2002222343A AU2234302A AU2002222343A1 AU 2002222343 A1 AU2002222343 A1 AU 2002222343A1 AU 2002222343 A AU2002222343 A AU 2002222343A AU 2234302 A AU2234302 A AU 2234302A AU 2002222343 A1 AU2002222343 A1 AU 2002222343A1
Authority
AU
Australia
Prior art keywords
ikb
ubiquitin
methods
identifying inhibitors
mediated proteolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002222343A
Other languages
English (en)
Inventor
Irit Alkalay
Yinon Ben-Neriah
Etti Ben-Shushan
Matti Davis
Ada Hatzubai
Avraham Yaron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of AU2002222343A1 publication Critical patent/AU2002222343A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2002222343A 2000-08-11 2001-08-10 Methods for identifying inhibitors of ubiquitin-mediated proteolysis of ikb Abandoned AU2002222343A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00117429A EP1182251A1 (fr) 2000-08-11 2000-08-11 Procédé pour l'identification de composés inhibant la protéolyse de IkB par l'ubiquitine
EP00117429.1 2000-08-11
PCT/IB2001/002428 WO2002016633A2 (fr) 2000-08-11 2001-08-10 Procede d'identification de composes inhibant la proteolyse a mediation assuree par l'ubiquitine de ikb

Publications (1)

Publication Number Publication Date
AU2002222343A1 true AU2002222343A1 (en) 2002-03-04

Family

ID=8169510

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002222343A Abandoned AU2002222343A1 (en) 2000-08-11 2001-08-10 Methods for identifying inhibitors of ubiquitin-mediated proteolysis of ikb

Country Status (5)

Country Link
US (1) US6905836B2 (fr)
EP (1) EP1182251A1 (fr)
AU (1) AU2002222343A1 (fr)
IL (1) IL154344A0 (fr)
WO (1) WO2002016633A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1182251A1 (fr) * 2000-08-11 2002-02-27 Yissum Research Development Company of the Hebrew University of Jerusalem Procédé pour l'identification de composés inhibant la protéolyse de IkB par l'ubiquitine
CA2488342A1 (fr) * 2002-06-05 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Medicaments therapeutiques destines au diabete
CN1658849A (zh) * 2002-06-05 2005-08-24 株式会社医药分子设计研究所 Ap－1和nfat活化抑制剂
WO2003103665A1 (fr) * 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 Anti-allergique
US7626042B2 (en) 2002-06-06 2009-12-01 Institute Of Medicinal Molecular Design, Inc. O-substituted hydroxyaryl derivatives
WO2003103655A1 (fr) * 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 Agent therapeutique pour soigner le cancer
EA010470B1 (ru) * 2002-06-10 2008-08-29 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. ИНГИБИТОРЫ АКТИВАЦИИ NF-kB
AU2003242124A1 (en) * 2002-06-11 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Medicament for treatment of neurodegenerative diseases
DE10308351A1 (de) * 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308355A1 (de) * 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308353A1 (de) * 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308354A1 (de) * 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Cycloalkylderivate mit biosteren Carbonsäure-Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2867783B1 (fr) * 2004-03-16 2008-02-01 Cytomics Systems Procede de criblage d'agent modulant l'ubiquitination de la proteine ikbalpha et moyens destines a la mise en oeuvre dudit procede
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
CN114807228B (zh) * 2020-04-27 2023-12-15 北京化工大学 一种t7rna聚合酶和t7启动子的表达系统及使用其在真核生物中表达蛋白质的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457026A (en) * 1992-11-20 1995-10-10 University Of Pennsylvania Methods of promoting intermolecular interactions involving a nucleic acid
US6573094B1 (en) * 1997-10-16 2003-06-03 Baylor College Of Medicine F-box genes and proteins
FR2774378A1 (fr) * 1998-01-30 1999-07-30 Inst Nat Sante Rech Med PROTEINE HUMAINE BETA-TrCP DE CIBLAGE DES PROTEINES VERS LES VOIES DE DEGRADATION PAR LE PROTEASOME
WO2000034447A2 (fr) * 1998-12-10 2000-06-15 Signal Pharmaceuticals, Inc. COMPOSES ET METHODES PERMETTANT DE MODULER L'ACTIVATION DE NF-λB
EP1182251A1 (fr) * 2000-08-11 2002-02-27 Yissum Research Development Company of the Hebrew University of Jerusalem Procédé pour l'identification de composés inhibant la protéolyse de IkB par l'ubiquitine

Also Published As

Publication number Publication date
US6905836B2 (en) 2005-06-14
US20040014026A1 (en) 2004-01-22
WO2002016633A3 (fr) 2003-02-06
IL154344A0 (en) 2003-09-17
EP1182251A1 (fr) 2002-02-27
WO2002016633A2 (fr) 2002-02-28

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