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AU2002220082A1 - Imaging of enzymatic activity - Google Patents

Imaging of enzymatic activity

Info

Publication number
AU2002220082A1
AU2002220082A1 AU2002220082A AU2008202A AU2002220082A1 AU 2002220082 A1 AU2002220082 A1 AU 2002220082A1 AU 2002220082 A AU2002220082 A AU 2002220082A AU 2008202 A AU2008202 A AU 2008202A AU 2002220082 A1 AU2002220082 A1 AU 2002220082A1
Authority
AU
Australia
Prior art keywords
imaging
enzymatic activity
enzymatic
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002220082A
Inventor
Alexei Bogdanov
Ralph Weissleder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of AU2002220082A1 publication Critical patent/AU2002220082A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing

Landscapes

  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU2002220082A 2000-10-19 2001-10-19 Imaging of enzymatic activity Abandoned AU2002220082A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24156600P 2000-10-19 2000-10-19
US60/241,566 2000-10-19
US31033501P 2001-08-06 2001-08-06
US60/310,335 2001-08-06
PCT/US2001/045532 WO2002032291A2 (en) 2000-10-19 2001-10-19 Imaging of enzymatic activity

Publications (1)

Publication Number Publication Date
AU2002220082A1 true AU2002220082A1 (en) 2002-04-29

Family

ID=26934397

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002220082A Abandoned AU2002220082A1 (en) 2000-10-19 2001-10-19 Imaging of enzymatic activity

Country Status (6)

Country Link
US (2) US6737247B2 (en)
EP (1) EP1326523A4 (en)
JP (1) JP2004530408A (en)
AU (1) AU2002220082A1 (en)
CA (1) CA2425873A1 (en)
WO (1) WO2002032291A2 (en)

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US6875864B2 (en) * 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
WO2001091807A2 (en) * 2000-06-02 2001-12-06 Board Of Regents Ethylenedicysteine (ec)-drug conjugates
WO2004044227A2 (en) 2002-11-07 2004-05-27 Board Of Regents, The University Of Texas System Ethylenedicysteine (ec)-drug conjugates, compositions and methods for tissue specific disease imaging
US9695251B2 (en) 2003-10-31 2017-07-04 The Regents Of The University Of California Activatable cell penetrating peptides with quenched fluorophores
US7985401B2 (en) 2003-10-31 2011-07-26 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US7431915B2 (en) 2003-10-31 2008-10-07 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US8153784B2 (en) * 2004-07-07 2012-04-10 The General Hospital Corporation Imaging of enzyme activity
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
JP5864077B2 (en) 2006-09-08 2016-02-17 ロード アイランド ホスピタル Treatment, prevention and recovery of alcohol-induced liver disease
EP2061442B1 (en) 2006-09-08 2016-08-31 Rhode Island Hospital Treatment, prevention, and reversal of alcohol-induced brain disease
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
WO2008064040A2 (en) * 2006-11-22 2008-05-29 The Board Of Regents Of The University Of Texas System Methods and compositions using chelator-antibody conjugates
AU2008230771B2 (en) 2007-03-27 2014-05-08 Radiomedix Inc. Compositions for targeted imaging and therapy
DE102007039899B3 (en) * 2007-08-23 2009-04-09 Siemens Ag Sensor for enabling the detection of a substance in the body of a living being
US8041008B2 (en) 2009-01-29 2011-10-18 The Invention Science Fund I, Llc Diagnostic delivery service
US8130904B2 (en) 2009-01-29 2012-03-06 The Invention Science Fund I, Llc Diagnostic delivery service
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
EP2435096A1 (en) * 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9682151B2 (en) 2009-07-15 2017-06-20 The Regents Of The University Of California Peptides whose uptake in cells is controllable
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
WO2012159107A1 (en) 2011-05-19 2012-11-22 Rhode Island Hospital Inhibition of renal fibrosis
DK2721045T3 (en) 2011-06-20 2017-07-24 Radiomedix Inc COMPOSITIONS, METHODS OF SYNTHESIS AND USE OF CARBOHYDRATE TARGETED AGENTS
US20150297761A1 (en) * 2012-11-12 2015-10-22 The General Hospital Corporation Peptidic structures incorporating an amino acid metal complex and applications in magnetic resonance imaging
US10029017B2 (en) 2013-01-29 2018-07-24 The Regents Of The University Of California Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug
CA2899448C (en) 2013-01-30 2021-10-26 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
EP4449997A3 (en) 2013-03-14 2025-01-15 Lumicell, Inc. Medical imaging device and methods of use
JP6584322B2 (en) 2013-12-27 2019-10-02 国立大学法人 東京医科歯科大学 Diagnostic method, diagnostic agent, therapeutic agent, and screening method for these agents for Alzheimer's disease and frontotemporal lobar degeneration
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
US10596259B2 (en) 2015-05-20 2020-03-24 The Regents Of The University Of California Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof
CN110577553B (en) * 2018-06-11 2021-09-21 天津师范大学 Synthetic method and application of three-dimensional porous complex based on six-core terbium cluster
KR102323277B1 (en) * 2019-12-02 2021-11-08 경북대학교 산학협력단 Novel gadolinium-based compound, pharmaceutical composition for treating or preventing inflammatory disease comprising the same, and mri contrast composition
US20230233714A1 (en) * 2020-01-22 2023-07-27 Kyungpook National University Industry-Academic Cooperation Foundation Novel gadolinium-based compound, method for producing same, and mri contrast agent containing same
KR102515875B1 (en) * 2020-01-22 2023-03-30 경북대학교 산학협력단 Novel gadolinium-based compound, method for the preparation thereof, and mri contrast agent comprising the same
US12370271B2 (en) 2020-01-22 2025-07-29 Kyungpook National University Industry-Academic Cooperation Foundation Gadolinium-based compound, preparation method therefor, and MRI contrast agent containing same
EP4095142A4 (en) * 2020-01-22 2024-01-17 Kyungpook National University Industry-Academic Cooperation Foundation Novel gadolinium-based compound, preparation method therefor, and mri contrast agent containing same
JP7668596B2 (en) * 2021-07-21 2025-04-25 テーランオキュア カンパニー リミテッド Gadolinium-based compounds and MRI contrast agents containing same
WO2023003412A1 (en) * 2021-07-21 2023-01-26 경북대학교 산학협력단 Gadolinium-based compound, and mri contrast agent including same
EP4374881A1 (en) * 2021-07-21 2024-05-29 Kyungpook National University Industry-Academic Cooperation Foundation Gadolinium-based compound and mri contrast agent comprising same
KR102659248B1 (en) * 2021-07-21 2024-04-19 경북대학교 산학협력단 Gadolinium-based compound, mri contrast agent comprising the same
KR102659253B1 (en) * 2021-12-03 2024-04-19 경북대학교 산학협력단 Gadolinium-based compound, mri contrast agent comprising the same

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US5482700A (en) 1987-03-31 1996-01-09 Schering Aktiengesellschaft Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
GB8927503D0 (en) * 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
US5254460A (en) 1990-05-03 1993-10-19 Advanced Magnetics, Inc. Solvent mediated relaxation assay system
US5559214A (en) * 1993-05-28 1996-09-24 Sterling Winthrop Inc. Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods
IT1274038B (en) * 1994-07-29 1997-07-14 Bracco Spa MACROCYCLIC CHELANTS THEIR CHELATES AND RELATED USES IN THE DIAGNOSTIC FIELD
US5980862A (en) 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5707605A (en) * 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
JP2001524095A (en) * 1997-04-22 2001-11-27 ニユコメド・イメージング・アクシエセルカペト NMR imaging compound

Also Published As

Publication number Publication date
US6737247B2 (en) 2004-05-18
EP1326523A2 (en) 2003-07-16
WO2002032291A3 (en) 2003-02-06
WO2002032291A2 (en) 2002-04-25
JP2004530408A (en) 2004-10-07
WO2002032291A9 (en) 2003-04-17
EP1326523A4 (en) 2005-01-05
CA2425873A1 (en) 2002-04-25
US20040241096A1 (en) 2004-12-02
US20020127629A1 (en) 2002-09-12

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