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AU2002241576A1 - Paramagnetic metal ion-based macrocyclic contrast agents - Google Patents

Paramagnetic metal ion-based macrocyclic contrast agents

Info

Publication number
AU2002241576A1
AU2002241576A1 AU2002241576A AU4157602A AU2002241576A1 AU 2002241576 A1 AU2002241576 A1 AU 2002241576A1 AU 2002241576 A AU2002241576 A AU 2002241576A AU 4157602 A AU4157602 A AU 4157602A AU 2002241576 A1 AU2002241576 A1 AU 2002241576A1
Authority
AU
Australia
Prior art keywords
metal ion
contrast agents
paramagnetic metal
based macrocyclic
macrocyclic contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002241576A
Inventor
A. Dean Sherry
Kuangcong Wu
Shanrong Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of AU2002241576A1 publication Critical patent/AU2002241576A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AU2002241576A 2000-11-20 2001-11-20 Paramagnetic metal ion-based macrocyclic contrast agents Abandoned AU2002241576A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25226900P 2000-11-20 2000-11-20
US60/252,269 2000-11-20
PCT/US2001/046151 WO2002043775A2 (en) 2000-11-20 2001-11-20 Paramagnetic metal ion-based macrocyclic contrast agents

Publications (1)

Publication Number Publication Date
AU2002241576A1 true AU2002241576A1 (en) 2002-06-11

Family

ID=22955292

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002241576A Abandoned AU2002241576A1 (en) 2000-11-20 2001-11-20 Paramagnetic metal ion-based macrocyclic contrast agents

Country Status (4)

Country Link
US (1) US6875419B2 (en)
EP (1) EP1390079A2 (en)
AU (1) AU2002241576A1 (en)
WO (1) WO2002043775A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
EP2025350A3 (en) * 1999-04-21 2009-12-09 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Determining pH by CEDST MRI
US7067111B1 (en) 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
WO2001091807A2 (en) 2000-06-02 2001-12-06 Board Of Regents Ethylenedicysteine (ec)-drug conjugates
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
JP4731117B2 (en) 2002-01-24 2011-07-20 バーンズ−ジューイッシュ ホスピタル Integrin targeted imaging agents
EP1331012A1 (en) 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
AU2004263136A1 (en) * 2003-08-08 2005-02-17 Barnes-Jewish Hospital Emulsion particles for imaging and therapy and methods of use thereof
US9050378B2 (en) 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US7504088B2 (en) 2004-06-09 2009-03-17 Kereos, Inc. Lipophilic derivatives of chelate monoamides
EP1793868B1 (en) * 2004-09-23 2010-12-29 Guerbet Liposomal contrast agents for cest imaging
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
EP1877813B1 (en) 2005-04-26 2013-06-19 Koninklijke Philips Electronics N.V. Mri involving contrast agent with time modulated contrast enhancement
US7917188B2 (en) * 2005-04-26 2011-03-29 Koninklijke Philips Electronics N.V. Method for using CEST contrast agents in MRI
DE602006008604D1 (en) * 2005-04-26 2009-10-01 Koninkl Philips Electronics Nv CONTRASTING AGENTS FOR MAGNETIC RESONANCE IMAGING WITH CEST-ACTIVE PARAMAGNETIC COMPLEX
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
US7330028B2 (en) * 2005-09-26 2008-02-12 General Electric Company Apparatus and method of simultaneous fat suppression, magnetization transfer contrast, and spatial saturation for 3D time-of-flight imaging
US8003078B2 (en) * 2006-03-29 2011-08-23 Barnes-Jewish Hospital Targeted MR imaging agents
EP2019667A4 (en) * 2006-04-27 2012-08-22 Barnes Jewish Hospital IDENTIFICATION AND IMAGING OF TARGET TISSUE
US20090142273A1 (en) * 2006-06-08 2009-06-04 Case Western Reserve University Activatable cest MRI agent
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
EP2205986B1 (en) * 2007-09-26 2013-07-03 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (cest) mri
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
US9302019B2 (en) * 2011-05-11 2016-04-05 The Research Foundation For The State University Of New York Fe(II) sequestering agents and uses thereof
WO2015142583A1 (en) 2014-03-17 2015-09-24 The Board Of Regents Of The University Of Texas System New gadolinium-based contrast agents for sensitive detection of zn2+ with mri
KR102668430B1 (en) * 2022-11-29 2024-05-24 재단법인 대구경북첨단의료산업진흥재단 New glutathione-sensitive compound and medical use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316757A (en) 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
MX174467B (en) 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-TRISCARBOXIMETHYL-1,4,7,10-TETRAAZACICLODO DECAN SUBSTITUTE IN 1 AND ANALOG COMPOUNDS
US5050609B1 (en) 1987-10-04 1999-11-02 Us Health Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging
US5914095A (en) 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
EP0489869B1 (en) * 1989-08-28 1998-11-11 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic nmr imaging
ATE199550T1 (en) 1993-12-30 2001-03-15 Guerbet Sa POLYAMINATED LIGANDS, METAL COMPLEXES, METHOD OF PREPARATION AND DIAGNOSTIC AND THERAPEUTIC USES
IT1291624B1 (en) 1997-04-18 1999-01-11 Bracco Spa COMPLEX CHELATES OF PARAMAGNETIC METALS WITH LOW TOXICITY
AU3225900A (en) * 1999-02-09 2000-08-29 Board Of Regents, The University Of Texas System Ph sensitive mri contrast agents
EP2025350A3 (en) 1999-04-21 2009-12-09 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Determining pH by CEDST MRI
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents

Also Published As

Publication number Publication date
US6875419B2 (en) 2005-04-05
WO2002043775A3 (en) 2003-12-18
EP1390079A2 (en) 2004-02-25
WO2002043775A2 (en) 2002-06-06
US20020127182A1 (en) 2002-09-12

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