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AU2001234119A1 - Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates - Google Patents

Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates

Info

Publication number
AU2001234119A1
AU2001234119A1 AU2001234119A AU3411901A AU2001234119A1 AU 2001234119 A1 AU2001234119 A1 AU 2001234119A1 AU 2001234119 A AU2001234119 A AU 2001234119A AU 3411901 A AU3411901 A AU 3411901A AU 2001234119 A1 AU2001234119 A1 AU 2001234119A1
Authority
AU
Australia
Prior art keywords
compound
group
intermediates
preparation
äivü
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001234119A
Inventor
Atsushi Akao
Masayuki Hagiwara
Shouichi Hiraga
Asayuki Kamatani
Masashi Kawasaki
Toshiaki Mase
Fumio Nakano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of AU2001234119A1 publication Critical patent/AU2001234119A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)

Abstract

This invention relates to a process for preparation of an indolopyrrolocarbazole derivative ÄIÜ by treating a compound ÄVÜ with a base in an inert solvent to prepare a compound ÄIVÜ, reacting the obtained compound ÄIVÜ with a compound ÄIIIÜ to prepare a compound ÄIIÜ and then removing the protective groups of the compound ÄIIÜ, the preparation intermediates compound ÄIIÜ, compound ÄIIIÜ and compound ÄIVÜ, and processes for preparation of the compound ÄIIIÜ. <CHEM> wherein Y<1> represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenyl group, a benzyloxymethyl group or an aralkyl group, R<1>, R<2>, R<3>, R<4>, R<5> and R<6> may be the same or different and each represent a protective group of a hydroxyl group, R<7> and R<8> may be the same or different and each represent a hydrogen atom or a protective group of a hydroxyl group, and X represents an acid molecule. This invention provides a safe and easy industrial preparation process of the indolopyrrolocarbazole derivative ÄIÜ useful as an antitumor agent.
AU2001234119A 2000-02-24 2001-02-22 Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates Abandoned AU2001234119A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-48140 2000-02-24
JP2000048140 2000-02-24
PCT/JP2001/001289 WO2001062769A1 (en) 2000-02-24 2001-02-22 Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates

Publications (1)

Publication Number Publication Date
AU2001234119A1 true AU2001234119A1 (en) 2001-09-03

Family

ID=18570268

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001234119A Abandoned AU2001234119A1 (en) 2000-02-24 2001-02-22 Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates

Country Status (13)

Country Link
US (1) US6790836B2 (en)
EP (1) EP1258490B1 (en)
JP (1) JP3388489B2 (en)
CN (1) CN1185247C (en)
AT (1) ATE255122T1 (en)
AU (1) AU2001234119A1 (en)
CA (1) CA2399209C (en)
DE (1) DE60101312T2 (en)
DK (1) DK1258490T3 (en)
ES (1) ES2210127T3 (en)
PT (1) PT1258490E (en)
TR (1) TR200302314T4 (en)
WO (1) WO2001062769A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1541582A1 (en) * 2002-08-23 2005-06-15 Banyu Pharmaceutical Co., Ltd. Process for producing indolopyrrolocarbazole derivative
AU2003248104A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd. Crystalline 6-n-pyridylmethylaminoindolocarbazoles
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
US20070197796A1 (en) * 2004-05-28 2007-08-23 Banyu Pharmaceuticals, Co., Ltd. Process for producing indolopyrrolocarbazole derivative

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5922860A (en) 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
WO1996004293A1 (en) 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
AU6836696A (en) * 1995-09-05 1997-03-27 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
JP3536574B2 (en) 1997-02-28 2004-06-14 萬有製薬株式会社 Antineoplastic indolopyrrolocarbazole derivatives
WO2002048166A1 (en) 2000-10-31 2002-06-20 Advanced Life Sciences, Inc. Indolocarbazole anticancer agents and methods of using them

Also Published As

Publication number Publication date
CA2399209A1 (en) 2001-08-30
EP1258490B1 (en) 2003-11-26
ES2210127T3 (en) 2004-07-01
CN1400976A (en) 2003-03-05
TR200302314T4 (en) 2004-01-21
US6790836B2 (en) 2004-09-14
CA2399209C (en) 2009-07-28
WO2001062769A1 (en) 2001-08-30
EP1258490A4 (en) 2003-04-02
PT1258490E (en) 2004-04-30
JP3388489B2 (en) 2003-03-24
US20030060621A1 (en) 2003-03-27
CN1185247C (en) 2005-01-19
ATE255122T1 (en) 2003-12-15
EP1258490A1 (en) 2002-11-20
DK1258490T3 (en) 2004-04-05
DE60101312D1 (en) 2004-01-08
DE60101312T2 (en) 2004-08-26

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