AU2001233928A1 - Cvd assay - Google Patents
Cvd assayInfo
- Publication number
- AU2001233928A1 AU2001233928A1 AU2001233928A AU3392801A AU2001233928A1 AU 2001233928 A1 AU2001233928 A1 AU 2001233928A1 AU 2001233928 A AU2001233928 A AU 2001233928A AU 3392801 A AU3392801 A AU 3392801A AU 2001233928 A1 AU2001233928 A1 AU 2001233928A1
- Authority
- AU
- Australia
- Prior art keywords
- assay
- cobalamin
- cardiovascular disease
- cvd
- holo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003556 assay Methods 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 2
- 208000033892 Hyperhomocysteinemia Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 102100040423 Transcobalamin-2 Human genes 0.000 abstract 1
- 101710124862 Transcobalamin-2 Proteins 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 230000003225 hyperhomocysteinemia Effects 0.000 abstract 1
- 230000002427 irreversible effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Gyroscopes (AREA)
- Optical Head (AREA)
Abstract
An assay method for the detection of cardiovascular disease, potential cardiovascular disease, megalobastic anemia, hyperhomocysteinemia or potential irreversible neurological disorders, in a human or non-human animal subject, said method comprising assessing, the concentration of both holo-transcobolamin II (holo TCII) and folate in a cobalamin-containing sample from said subject and the optional assessment of total sample cobalamin. A kit for carrying out the assay method is also provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0004040.2A GB0004040D0 (en) | 2000-02-21 | 2000-02-21 | Assay |
| GB0004040 | 2000-02-21 | ||
| PCT/GB2001/000747 WO2001063298A2 (en) | 2000-02-21 | 2001-02-21 | Diagnosis of cvd measuring folate and holo-tcii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001233928A1 true AU2001233928A1 (en) | 2001-09-03 |
Family
ID=9886094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001233928A Abandoned AU2001233928A1 (en) | 2000-02-21 | 2001-02-21 | Cvd assay |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040253745A1 (en) |
| EP (1) | EP1257831B1 (en) |
| JP (1) | JP2003524186A (en) |
| AT (1) | ATE325345T1 (en) |
| AU (1) | AU2001233928A1 (en) |
| CY (1) | CY1105520T1 (en) |
| DE (1) | DE60119289T2 (en) |
| DK (1) | DK1257831T3 (en) |
| ES (1) | ES2262627T3 (en) |
| GB (1) | GB0004040D0 (en) |
| PT (1) | PT1257831E (en) |
| WO (1) | WO2001063298A2 (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133951A (en) * | 1975-05-08 | 1979-01-09 | The Radiochemical Centre Limited | Vitamin B-12 cobalt-57 and process |
| US4273757A (en) * | 1977-06-02 | 1981-06-16 | Yissum Research Development Company | Determination of transcobalamins |
| US4418151A (en) * | 1981-03-30 | 1983-11-29 | Rohm And Haas Company | Assay process with non-boiling denaturation |
| US4680273A (en) * | 1985-07-29 | 1987-07-14 | Victor Herbert | Assay for vitamin B12 deficiency |
| US5715835A (en) * | 1992-11-19 | 1998-02-10 | Anticancer, Inc. | Methods for treating and reducing the potential for cardiovascular disease using methioninase compositions |
| DE19647352C2 (en) * | 1996-11-15 | 2000-06-29 | Aqua Nova Getraenketechnologie | Non-alcoholic beverage containing Q 10 |
| WO2000000821A1 (en) * | 1998-06-29 | 2000-01-06 | Ullman Edwin F | Assay for homocysteine |
| EP1105739A1 (en) * | 1998-08-20 | 2001-06-13 | Axis-Shield Asa | Assay method for cardiovascular disease |
-
2000
- 2000-02-21 GB GBGB0004040.2A patent/GB0004040D0/en not_active Ceased
-
2001
- 2001-02-21 AU AU2001233928A patent/AU2001233928A1/en not_active Abandoned
- 2001-02-21 JP JP2001562211A patent/JP2003524186A/en active Pending
- 2001-02-21 PT PT01905964T patent/PT1257831E/en unknown
- 2001-02-21 EP EP01905964A patent/EP1257831B1/en not_active Expired - Lifetime
- 2001-02-21 DE DE60119289T patent/DE60119289T2/en not_active Expired - Fee Related
- 2001-02-21 AT AT01905964T patent/ATE325345T1/en not_active IP Right Cessation
- 2001-02-21 ES ES01905964T patent/ES2262627T3/en not_active Expired - Lifetime
- 2001-02-21 DK DK01905964T patent/DK1257831T3/en active
- 2001-02-21 US US10/204,458 patent/US20040253745A1/en not_active Abandoned
- 2001-02-21 WO PCT/GB2001/000747 patent/WO2001063298A2/en not_active Ceased
-
2006
- 2006-07-31 CY CY20061101064T patent/CY1105520T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1257831B1 (en) | 2006-05-03 |
| CY1105520T1 (en) | 2010-07-28 |
| WO2001063298A3 (en) | 2002-05-16 |
| GB0004040D0 (en) | 2000-04-12 |
| JP2003524186A (en) | 2003-08-12 |
| DE60119289D1 (en) | 2006-06-08 |
| DE60119289T2 (en) | 2007-04-19 |
| EP1257831A2 (en) | 2002-11-20 |
| US20040253745A1 (en) | 2004-12-16 |
| PT1257831E (en) | 2006-08-31 |
| ATE325345T1 (en) | 2006-06-15 |
| DK1257831T3 (en) | 2006-08-28 |
| ES2262627T3 (en) | 2006-12-01 |
| WO2001063298A2 (en) | 2001-08-30 |
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