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AU2001229564A1 - Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier - Google Patents

Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier

Info

Publication number
AU2001229564A1
AU2001229564A1 AU2001229564A AU2956401A AU2001229564A1 AU 2001229564 A1 AU2001229564 A1 AU 2001229564A1 AU 2001229564 A AU2001229564 A AU 2001229564A AU 2956401 A AU2956401 A AU 2956401A AU 2001229564 A1 AU2001229564 A1 AU 2001229564A1
Authority
AU
Australia
Prior art keywords
amplifier
lock
phase
measuring
modulation fluorometer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001229564A
Inventor
Peter Harms
Govind Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore County UMBC
The University of Maryland Biotechnology Institute
Original Assignee
University of Maryland Baltimore County UMBC
University of Maryland College Park
The University of Maryland Biotechnology Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Maryland Baltimore County UMBC, University of Maryland College Park, The University of Maryland Biotechnology Institute filed Critical University of Maryland Baltimore County UMBC
Publication of AU2001229564A1 publication Critical patent/AU2001229564A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AU2001229564A 2000-01-19 2001-01-18 Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier Abandoned AU2001229564A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/487,275 2000-01-19
US09/487,275 US6426505B1 (en) 2000-01-19 2000-01-19 Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier
PCT/US2001/001569 WO2001053808A1 (en) 2000-01-19 2001-01-18 Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier

Publications (1)

Publication Number Publication Date
AU2001229564A1 true AU2001229564A1 (en) 2001-07-31

Family

ID=23935073

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001229564A Abandoned AU2001229564A1 (en) 2000-01-19 2001-01-18 Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier

Country Status (3)

Country Link
US (1) US6426505B1 (en)
AU (1) AU2001229564A1 (en)
WO (1) WO2001053808A1 (en)

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Publication number Priority date Publication date Assignee Title
US6673626B1 (en) * 2000-10-31 2004-01-06 Science & Technology Corporation University Of New Mexico Optoelectronic circuit for detecting changes in fluorescence lifetime
DE10056384C2 (en) * 2000-11-14 2003-06-05 Leica Microsystems Device for measuring the lifespan of an excited state in a sample and use of the device
GB2404013B (en) * 2003-07-17 2006-05-31 Isis Innovation Apparatus for and method of measuring fluorescence lifetime
US7332700B2 (en) * 2004-04-26 2008-02-19 Bruce Masato Ishimoto Photomultiplier tube with dynode modulation for photon-counting
US7276857B2 (en) * 2004-05-06 2007-10-02 Continuum Electro-Optics, Inc. Methods and apparatus for an improved amplifier for driving a non-linear load
WO2005112522A2 (en) * 2004-05-06 2005-11-24 Continuum Electro-Optics, Inc. Methods and apparatus for an improved amplifier for driving a non-linear load
US20060159589A1 (en) * 2005-01-14 2006-07-20 Indu Saxena Bacteria sensor and method
US7741108B2 (en) * 2005-01-14 2010-06-22 Optech Ventures, Llc Bacteria sensor and method
US20060237664A1 (en) * 2005-04-25 2006-10-26 Polestar Technologies, Inc. Feedback control system
US8552401B2 (en) * 2005-04-25 2013-10-08 Polestar Technologies, Inc. Optical chemical sensor feedback control system
US7772009B2 (en) * 2005-11-22 2010-08-10 SCR Research, LLC Room temperature phosphorescence apparatus and methods
US8563251B2 (en) * 2006-05-12 2013-10-22 San Diego State University (Sdsu) Foundation High-throughput methods for quantifying cells in environmental and laboratory samples
US7824902B2 (en) * 2006-11-03 2010-11-02 Mark Selker Optical interface for disposable bioreactors
DE102006059652A1 (en) * 2006-12-18 2008-06-26 Tyco Electronics Raychem Gmbh A method of processing an analog sensor signal in a gas sensor assembly and measurement processing device
CN101207957B (en) * 2007-12-19 2011-01-19 北京交通大学 High frequency modulated light source for nanosecond level fluorescence lifetime measurement
US8143597B1 (en) * 2008-01-14 2012-03-27 The United States Of America As Represented By The Secretary Of The Air Force Remote sensing phase fluorimetry using mercury vapor lamp
JP2011529577A (en) * 2008-07-28 2011-12-08 センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド System and method for optical measurement of analyte concentration
CN102159937A (en) * 2008-09-19 2011-08-17 三井造船株式会社 Fluorescence detection device by means of intensity moludated laser light and method for detecting fluorscence
US7968840B2 (en) * 2008-10-28 2011-06-28 Finesse Solutions, Llc Optical phase reference
ES2334426B1 (en) * 2009-06-10 2010-09-27 Adasa Sistemas, S.A.U. OPTICAL PROCEDURE AND MODULE FOR MEASURING ABSORBANCE TO DISCRETE LAMBS FOR WATER QUALITY CONTROL APPLICATIONS.
WO2013019904A2 (en) * 2011-08-01 2013-02-07 Infrared Imaging Systems, Inc. Disposable light source for enhanced visualization of subcutaneous structures
US9632030B1 (en) 2012-11-05 2017-04-25 Arrowhead Center, Inc. Methods of measuring fluorescence lifetime using a flow cytometer
US10753794B2 (en) 2015-05-28 2020-08-25 Empire Technology Development Llc Concurrent activation of multiple illumination sources for sample analysis
US10698013B2 (en) * 2015-11-27 2020-06-30 Samsung Electronics Co., Ltd. Lock-in amplifier, integrated circuit and portable measurement device including the same
WO2017156413A1 (en) * 2016-03-10 2017-09-14 University Of Notre Dame Super-sensitivity multiphoton frequency-domain fluorescence lifetime imaging microscopy
KR102005832B1 (en) * 2018-02-21 2019-08-01 주식회사 올리브헬스케어 Signal processing device for bio-signal analysing and bio-signal analysing apparatus using the same
US11604143B2 (en) 2020-05-20 2023-03-14 Ysi, Inc. Spatial gradient-based fluorometer
CN115607110B (en) * 2022-10-18 2023-11-21 广州大学 Mammary gland tumor detection system based on autofluorescence

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US3354315A (en) 1964-08-25 1967-11-21 Monsanto Co Flash photolysis spectroscopic system
US4059405A (en) 1972-04-11 1977-11-22 Damon Corporation Method and apparatus for analysis of constituent carried in fibrous medium
US5302349A (en) 1989-06-13 1994-04-12 Diatron Corporation Transient-state luminescence assay apparatus
US5315993A (en) 1990-02-16 1994-05-31 The Boc Group, Inc. Luminescence monitoring with modulation frequency multiplexing
US5141312A (en) 1990-06-01 1992-08-25 The United States Of America As Represented By The Secretary Of The Navy Fiber optic photoluminescence sensor
EP0552241B1 (en) 1990-10-10 2000-06-28 The University Of Maryland Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
US5308771A (en) 1992-04-13 1994-05-03 Geo-Centers, Inc. Chemical sensors
US5293210A (en) 1992-04-24 1994-03-08 Becton, Dickinson And Company Detection of bacteria in blood culture bottles by time-resolved light scattering and absorption measurement
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US5593854A (en) 1994-02-16 1997-01-14 Becton Dickinson And Company Data analysis method for use with fluorescent bacterial sensors
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US5686300A (en) 1995-09-11 1997-11-11 Becton Dickinson And Company Fluorescence detector
US5863460A (en) 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US5818582A (en) 1996-09-19 1998-10-06 Ciencia, Inc. Apparatus and method for phase fluorometry

Also Published As

Publication number Publication date
WO2001053808A1 (en) 2001-07-26
US6426505B1 (en) 2002-07-30
WO2001053808A9 (en) 2002-10-17

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