AU2001225466A1 - Pyrimidine derivatives having antitumor effect - Google Patents
Pyrimidine derivatives having antitumor effectInfo
- Publication number
- AU2001225466A1 AU2001225466A1 AU2001225466A AU2546601A AU2001225466A1 AU 2001225466 A1 AU2001225466 A1 AU 2001225466A1 AU 2001225466 A AU2001225466 A AU 2001225466A AU 2546601 A AU2546601 A AU 2546601A AU 2001225466 A1 AU2001225466 A1 AU 2001225466A1
- Authority
- AU
- Australia
- Prior art keywords
- antitumor effect
- pyrimidine derivatives
- alkyl
- hydrogen atom
- independently hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A compound represented by the formula (I): <CHEM> wherein, for example, R<1>, R<2>, R<3>, and R<4> are each independently hydrogen atom, alkyl, and the like, R<5> and R<6> are each independently hydrogen atom, alkyl, and the like, R<B> and R<C> are each independently hydrogen atom, alkyl, and the like, X is -O-, -S-, and the like, Y is 5- membered heteroaryl-diyl and the like, Z is optionally substituted aryl and the like, their pharmaceutically acceptable salts, or their solvates.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000005553 | 2000-01-14 | ||
| JP2000-5553 | 2000-01-14 | ||
| PCT/JP2001/000036 WO2001051488A1 (en) | 2000-01-14 | 2001-01-09 | Pyrimidine derivatives having antitumor effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001225466A1 true AU2001225466A1 (en) | 2001-07-24 |
Family
ID=18534207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001225466A Abandoned AU2001225466A1 (en) | 2000-01-14 | 2001-01-09 | Pyrimidine derivatives having antitumor effect |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6800630B2 (en) |
| EP (1) | EP1251129B1 (en) |
| KR (1) | KR20020079779A (en) |
| CN (1) | CN1416429A (en) |
| AT (1) | ATE268769T1 (en) |
| AU (1) | AU2001225466A1 (en) |
| CA (1) | CA2396324A1 (en) |
| DE (1) | DE60103732T2 (en) |
| ES (1) | ES2222331T3 (en) |
| WO (1) | WO2001051488A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2983636B2 (en) * | 1993-10-01 | 1999-11-29 | ノバルティス アクチェンゲゼルシャフト | Pharmacologically active pyridine derivative and method for producing the same |
| US5608067A (en) * | 1993-12-09 | 1997-03-04 | Afonso; Adriano | 4-substituted pyrazoloquinoline derivatives |
| US5439918A (en) * | 1994-03-14 | 1995-08-08 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CN1146561C (en) * | 1998-07-16 | 2004-04-21 | 盐野义制药株式会社 | Pyrimidine derivatives having antitumor activity |
-
2001
- 2001-01-09 US US10/169,993 patent/US6800630B2/en not_active Expired - Fee Related
- 2001-01-09 EP EP01900628A patent/EP1251129B1/en not_active Expired - Lifetime
- 2001-01-09 KR KR1020027008947A patent/KR20020079779A/en not_active Abandoned
- 2001-01-09 AU AU2001225466A patent/AU2001225466A1/en not_active Abandoned
- 2001-01-09 DE DE60103732T patent/DE60103732T2/en not_active Expired - Fee Related
- 2001-01-09 WO PCT/JP2001/000036 patent/WO2001051488A1/en not_active Ceased
- 2001-01-09 AT AT01900628T patent/ATE268769T1/en not_active IP Right Cessation
- 2001-01-09 CA CA002396324A patent/CA2396324A1/en not_active Abandoned
- 2001-01-09 CN CN01806196A patent/CN1416429A/en active Pending
- 2001-01-09 ES ES01900628T patent/ES2222331T3/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60103732D1 (en) | 2004-07-15 |
| CN1416429A (en) | 2003-05-07 |
| KR20020079779A (en) | 2002-10-19 |
| EP1251129A4 (en) | 2003-03-05 |
| DE60103732T2 (en) | 2005-06-30 |
| ATE268769T1 (en) | 2004-06-15 |
| CA2396324A1 (en) | 2001-07-19 |
| US6800630B2 (en) | 2004-10-05 |
| EP1251129A1 (en) | 2002-10-23 |
| WO2001051488A1 (en) | 2001-07-19 |
| US20030203894A1 (en) | 2003-10-30 |
| EP1251129B1 (en) | 2004-06-09 |
| ES2222331T3 (en) | 2005-02-01 |
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