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AU2001296173A1 - 3,8-diazabicyclo(3.2.1)octanes and their use in the treatment of cardiac arrhythmias - Google Patents

3,8-diazabicyclo(3.2.1)octanes and their use in the treatment of cardiac arrhythmias

Info

Publication number
AU2001296173A1
AU2001296173A1 AU2001296173A AU9617301A AU2001296173A1 AU 2001296173 A1 AU2001296173 A1 AU 2001296173A1 AU 2001296173 A AU2001296173 A AU 2001296173A AU 9617301 A AU9617301 A AU 9617301A AU 2001296173 A1 AU2001296173 A1 AU 2001296173A1
Authority
AU
Australia
Prior art keywords
octanes
diazabicyclo
treatment
cardiac arrhythmias
arrhythmias
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001296173A
Inventor
Magnus Bjorsne
Kurt-Jurgen Hoffmann
Fritiof Ponten
Gert Strandlund
Peder Svensson
Michael Wilstermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2001296173A1 publication Critical patent/AU2001296173A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2001296173A 2000-10-20 2001-10-18 3,8-diazabicyclo(3.2.1)octanes and their use in the treatment of cardiac arrhythmias Abandoned AU2001296173A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0003795A SE0003795D0 (en) 2000-10-20 2000-10-20 Pharmaceutically useful compounds
SE0003795 2000-10-20
PCT/SE2001/002294 WO2002032902A1 (en) 2000-10-20 2001-10-18 3,8-diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
AU2001296173A1 true AU2001296173A1 (en) 2002-04-29

Family

ID=20281488

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001296173A Abandoned AU2001296173A1 (en) 2000-10-20 2001-10-18 3,8-diazabicyclo(3.2.1)octanes and their use in the treatment of cardiac arrhythmias

Country Status (6)

Country Link
US (1) US7012074B2 (en)
EP (1) EP1328526A1 (en)
JP (1) JP2004511559A (en)
AU (1) AU2001296173A1 (en)
SE (1) SE0003795D0 (en)
WO (1) WO2002032902A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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DE60203623T2 (en) * 2001-07-19 2006-01-19 CV Therapeutics, Inc., Palo Alto SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS FATTY-OXIDATION INHIBITORS
DE60314662T2 (en) * 2002-12-05 2008-03-13 CV Therapeutics, Inc., Palo Alto SUBSTITUTED PIPERAZIN COMPOUNDS AND THEIR USE AS FATTY ACIDATION INHIBITORS
US7205303B2 (en) * 2003-01-03 2007-04-17 Cv Therapeutics, Inc. Substituted heterocyclic compounds
EP1583751A1 (en) * 2003-01-17 2005-10-12 Cv Therapeutics, Inc. Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases
CA2530376A1 (en) * 2003-06-23 2005-01-06 Cv Therapeutics, Inc. Urea derivatives of piperazines and piperidines as fatty acid oxidation inhibitors
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN107383025B (en) * 2017-06-30 2019-04-26 吉林凯莱英医药化学有限公司 The preparation method of endocyclic compound
CN111892599B (en) * 2020-08-14 2023-01-13 黄芳 Synthesis method of 2,5-diazabicyclo [2.2.2] octane-2-tert-butyl carboxylate

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DE3112055A1 (en) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen BISPIDINE DERIVATIVES, THEIR PRODUCTION AND THE MEDICINAL PRODUCTS CONTAINING THEM
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DE3234697A1 (en) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover NEW DIAZABICYCLO (3,3,1) NONANA
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EP0251308B1 (en) 1986-07-04 1990-11-22 Chemie Linz Gesellschaft m.b.H. 4-quinolone-3-carboxylic-acid derivatives, process for their synthesis and pharmaceutical preparations containing them
ZA877471B (en) 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
DE3702393A1 (en) 1987-01-28 1988-08-11 Bayer Ag 8-CYANO-1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO- 3-CHINOLINE CARBONIC ACIDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS CONTAINING THEM
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
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US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
KR920004385A (en) 1990-08-09 1992-03-27 와꾸나가 기스께 New tricyclic compounds or salts thereof, preparation method thereof and antimicrobial agent containing same
KR930703292A (en) 1991-12-27 1993-11-29 쿠사이 요시히로 Novel quinolone derivatives or salts thereof and antimicrobial agents containing the compounds
CZ236494A3 (en) 1992-04-03 1994-12-15 Upjohn Co Pharmaceutically active bicyclic-heterocyclic amines
IT1271350B (en) 1993-01-29 1997-05-27 Riace Establischment DERIVATIVES OF 3.8 DIAZABICICLO (3,2,1) - OCTAN AS CENTRAL ANALGESIC MEDICATIONS
TW301607B (en) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
TW273551B (en) 1993-05-24 1996-04-01 Wakiei Seiyaku Kk
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
DE69416869T2 (en) 1993-12-29 1999-07-01 Pfizer Inc., New York, N.Y. DIAZABICYCLIC NEUROKININ ANTAGONISTS
DE4402931A1 (en) 1994-02-01 1995-08-03 Kali Chemie Pharma Gmbh New drugs containing 3-phenylsulfonyl-3,7-diazabicyclo [3,3,1] nonane compounds
IT1274018B (en) 1994-02-23 1997-07-14 Riace Ets 3,8-DIAZABICYCLE DERIVATIVES (3.2.1.) OCTANO FOR ANALGESIC ACTIVITY
CA2196062A1 (en) 1994-07-29 1996-02-15 Yoshinari Sato Benzodiazepine derivatives
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
CA2218503C (en) 1995-04-20 2001-07-24 Pfizer Inc. Arylsulfonyl hydroxamic acid derivatives
FR2733984B1 (en) 1995-05-10 1997-07-04 Rhone Poulenc Rorer Sa TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0825186B1 (en) 1996-08-16 2002-04-17 Pfizer Inc. 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression
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Also Published As

Publication number Publication date
US20040023971A1 (en) 2004-02-05
EP1328526A1 (en) 2003-07-23
SE0003795D0 (en) 2000-10-20
WO2002032902A1 (en) 2002-04-25
US7012074B2 (en) 2006-03-14
JP2004511559A (en) 2004-04-15

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