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AU2001296033A1 - Novel guanosine triphosphate (gtp) binding protein-coupled receptor protein, bg37 - Google Patents

Novel guanosine triphosphate (gtp) binding protein-coupled receptor protein, bg37

Info

Publication number
AU2001296033A1
AU2001296033A1 AU2001296033A AU9603301A AU2001296033A1 AU 2001296033 A1 AU2001296033 A1 AU 2001296033A1 AU 2001296033 A AU2001296033 A AU 2001296033A AU 9603301 A AU9603301 A AU 9603301A AU 2001296033 A1 AU2001296033 A1 AU 2001296033A1
Authority
AU
Australia
Prior art keywords
novel
protein
coupled receptor
gtp
guanosine triphosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001296033A
Inventor
Hiraku Itadani
Takaharu Maruyama
Takao Nakamura
Kenichi Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27345218&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001296033(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of AU2001296033A1 publication Critical patent/AU2001296033A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene "BG37". cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR "BG37" genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the "BG37" receptor.
AU2001296033A 2000-11-17 2001-10-30 Novel guanosine triphosphate (gtp) binding protein-coupled receptor protein, bg37 Abandoned AU2001296033A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2000351741 2000-11-17
JP2000-351741 2000-11-17
JP2001-38619 2001-02-15
JP2001038619 2001-02-15
JP2001-77000 2001-03-16
JP2001077000 2001-03-16
PCT/JP2001/009512 WO2002040669A1 (en) 2000-11-17 2001-10-30 Novel guanosine triphosphate (gtp) binding protein-coupled receptor protein, bg37

Publications (1)

Publication Number Publication Date
AU2001296033A1 true AU2001296033A1 (en) 2002-05-27

Family

ID=27345218

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001296033A Abandoned AU2001296033A1 (en) 2000-11-17 2001-10-30 Novel guanosine triphosphate (gtp) binding protein-coupled receptor protein, bg37

Country Status (8)

Country Link
US (3) US7198914B2 (en)
EP (1) EP1347052B1 (en)
JP (1) JP4003069B2 (en)
AT (1) ATE466939T1 (en)
AU (1) AU2001296033A1 (en)
CA (1) CA2429214A1 (en)
DE (1) DE60142079D1 (en)
WO (1) WO2002040669A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354726B2 (en) 2001-04-12 2008-04-08 Takeda Pharmaceutical Company Limited Screening method
GB0208407D0 (en) 2001-10-01 2002-05-22 Aventis Pharma Inc A novel G protein-coupled receptor, GAVE10
JP2005520498A (en) * 2001-12-17 2005-07-14 ノバルティス アクチエンゲゼルシャフト Novel G protein coupled receptor and DNA sequence thereof
AU2003277663A1 (en) * 2002-11-12 2004-06-03 Takeda Pharmaceutical Company Limited Screening method
US20060240013A1 (en) * 2002-11-22 2006-10-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with bile acid g-protein-coupled receptor 37 (bg37)
EP1591120A4 (en) * 2003-01-28 2009-06-10 Takeda Chemical Industries Ltd Receptor agonists
US20080306114A1 (en) * 2004-04-13 2008-12-11 Arena Pharmaceuticals, Inc Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Hyperglycemia and Related Disorders
CA2592461A1 (en) * 2004-12-27 2006-07-06 Banyu Pharmaceutical Co., Ltd. Drugs for diseases accompanying changes in total bile acid pool or lipid metabolism disorders and method of screening these drugs
WO2007050628A2 (en) 2005-10-24 2007-05-03 Andrew Young Biliary/pancreatic shunt device and method for treatment of metabolic and other diseases
US8759364B2 (en) * 2008-03-31 2014-06-24 The Trustees Of Columbia University In The City Of New York Methods of treating bone mass diseases
WO2010016552A1 (en) 2008-08-07 2010-02-11 武田薬品工業株式会社 Therapeutic agent for irritable bowel syndrome
JP2012509892A (en) 2008-11-26 2012-04-26 サティオゲン ファーマシューティカルズ，インク． Compositions containing satiogens and methods of use
WO2010062861A2 (en) 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
US8815883B2 (en) 2009-11-02 2014-08-26 The Trustees Of Columbia Unviersity In The City Of New York Compounds and methods for inhibiting serotonin synthesis
EP2995317A1 (en) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
DK2771003T3 (en) 2011-10-28 2017-07-17 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for the treatment of pediatric cholestatic liver disease
US20140323412A1 (en) 2011-10-28 2014-10-30 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09268A (en) 1994-08-11 1997-01-07 Takeda Chem Ind Ltd New g protein conjugation type receptor protein, its production and use
US5858716A (en) * 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
JP2002518010A (en) 1998-06-16 2002-06-25 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 94 human secreted proteins
JP2000189171A (en) 1998-12-25 2000-07-11 Banyu Pharmaceut Co Ltd Novel guanosine triphosphate (GTP) binding protein-coupled receptor protein
CA2368216A1 (en) 1999-03-25 2000-10-05 Banyu Pharmaceutical Co., Ltd. Novel guanosine triphosphate (gtp)-binding protein-coupled receptor proteins, bg3
JP3221607B2 (en) 1999-06-08 2001-10-22 学校法人加計学園 Method for synthesizing substituted phenyl compounds
JP3451338B2 (en) 1999-07-30 2003-09-29 株式会社シギヤ精機製作所 Grinding wheel diameter measuring device in grinder
JP2001077000A (en) 1999-09-02 2001-03-23 Nikon Corp Pattern dividing method and semiconductor device manufacturing method
WO2001046414A1 (en) 1999-12-20 2001-06-28 Banyu Pharmaceutical Co., Ltd. Novel guanosine triphosphate-binding protein-coupled receptor protein, bg26
WO2002008258A2 (en) * 2000-07-21 2002-01-31 Millennium Pharmaceuticals, Inc. 65494, a human g-protein-coupled receptor family member and uses thereof
CA2401290A1 (en) 2000-04-12 2001-10-18 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2002010387A2 (en) 2000-07-27 2002-02-07 Incyte Genomics, Inc. G-protein coupled receptors
JP2002112793A (en) * 2000-08-04 2002-04-16 Japan Science & Technology Corp New g protein-coupled receptor
EP1364026B1 (en) 2001-02-20 2008-05-07 Bayer HealthCare AG Human g protein-coupled receptor
US6783969B1 (en) * 2001-03-05 2004-08-31 Nuvelo, Inc. Cathepsin V-like polypeptides
US7354726B2 (en) 2001-04-12 2008-04-08 Takeda Pharmaceutical Company Limited Screening method
EP1382678B1 (en) 2001-04-25 2008-08-27 Astellas Pharma Inc. Guanosine triphosphate-binding protein-coupled recepotr place 6002312 and its gene and production and use of the same

Also Published As

Publication number Publication date
WO2002040669A1 (en) 2002-05-23
EP1347052B1 (en) 2010-05-05
US20070141642A1 (en) 2007-06-21
US20100184236A1 (en) 2010-07-22
US7198914B2 (en) 2007-04-03
EP1347052A1 (en) 2003-09-24
ATE466939T1 (en) 2010-05-15
US7723046B2 (en) 2010-05-25
EP1347052A4 (en) 2006-07-19
US8076455B2 (en) 2011-12-13
US20040086898A1 (en) 2004-05-06
JPWO2002040669A1 (en) 2005-06-02
CA2429214A1 (en) 2003-05-15
JP4003069B2 (en) 2007-11-07
DE60142079D1 (en) 2010-06-17

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