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AU2001294264A1 - Process for the preparation of acylphenylalanines - Google Patents

Process for the preparation of acylphenylalanines

Info

Publication number
AU2001294264A1
AU2001294264A1 AU2001294264A AU9426401A AU2001294264A1 AU 2001294264 A1 AU2001294264 A1 AU 2001294264A1 AU 2001294264 A AU2001294264 A AU 2001294264A AU 9426401 A AU9426401 A AU 9426401A AU 2001294264 A1 AU2001294264 A1 AU 2001294264A1
Authority
AU
Australia
Prior art keywords
acylphenylalanines
preparation
solvent
acylphenylalanine
phenylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001294264A
Inventor
Takao Ohgane
Michito Sumikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of AU2001294264A1 publication Critical patent/AU2001294264A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under the alkali condition by using potassium hydroxide.
AU2001294264A 2000-10-18 2001-10-16 Process for the preparation of acylphenylalanines Abandoned AU2001294264A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-317603 2000-10-18
JP2000317603 2000-10-18
PCT/JP2001/009068 WO2002032853A1 (en) 2000-10-18 2001-10-16 Process for the preparation of acylphenylalanines

Publications (1)

Publication Number Publication Date
AU2001294264A1 true AU2001294264A1 (en) 2002-04-29

Family

ID=18796361

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001294264A Abandoned AU2001294264A1 (en) 2000-10-18 2001-10-16 Process for the preparation of acylphenylalanines

Country Status (18)

Country Link
US (2) US7030268B2 (en)
EP (1) EP1334962B1 (en)
JP (1) JP4158192B2 (en)
KR (1) KR100783306B1 (en)
CN (1) CN1273442C (en)
AT (1) ATE373635T1 (en)
AU (1) AU2001294264A1 (en)
BR (1) BR0114728B1 (en)
CA (1) CA2425533C (en)
CY (1) CY1107502T1 (en)
DE (1) DE60130575T2 (en)
DK (1) DK1334962T3 (en)
ES (1) ES2290173T3 (en)
MX (1) MXPA03003483A (en)
PT (1) PT1334962E (en)
RU (1) RU2287520C2 (en)
TW (1) TW575541B (en)
WO (1) WO2002032853A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283054A4 (en) * 2000-03-17 2006-04-12 Ajinomoto Kk Drugs for complications of diabetes and neuropathy and utilization thereof
KR100819358B1 (en) * 2000-10-18 2008-04-04 아지노모토 가부시키가이샤 Method for preparing nateglinide crystal
ATE373635T1 (en) * 2000-10-18 2007-10-15 Ajinomoto Kk METHOD FOR PRODUCING ACYLPHENYLALANINES
WO2002034713A1 (en) * 2000-10-24 2002-05-02 Ajinomoto Co.,Inc. Process for producing b-form nateglinide crystal
AU2001296000A1 (en) * 2000-10-24 2002-05-27 Ajinomoto Co., Inc. Nateglinide-containing hydrophilic drug preparations
DK1334720T3 (en) * 2000-10-24 2009-01-19 Ajinomoto Kk Nateglinide-containing preparations
ATE349418T1 (en) * 2003-11-26 2007-01-15 A M S A Anonima Materie Sint E METHOD FOR PRODUCING B-FORM NATEGLINIDINE
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
KR20070102694A (en) * 2005-01-31 2007-10-19 아지노모토 가부시키가이샤 Pharmaceutical composition for improving or treating hyperglycemia, borderline diabetes, insulin resistance and hyperinsulinemia containing hypoglycemic agents
JP5152699B2 (en) * 2006-03-31 2013-02-27 味の素株式会社 Method for producing carboxylic acid chloride compound
KR20130087485A (en) 2010-06-14 2013-08-06 씨아이피엘에이 엘티디. A process for the preparation of nateglinide
CN115340857B (en) * 2022-08-24 2024-03-26 宁波锋成先进能源材料研究院有限公司 In-situ self-emulsifying nano oil displacement agent and preparation method and application thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59190926A (en) 1983-04-14 1984-10-29 Ajinomoto Co Inc Agent for providing absorption characteristic
JPS58189121A (en) 1982-04-30 1983-11-04 Ajinomoto Co Inc Activator for administration of insulin
DE3382112D1 (en) * 1982-04-30 1991-02-21 Ajinomoto Kk PHARMACEUTICAL COMPOSITION.
AU567460B2 (en) * 1984-03-05 1987-11-19 Mitsui Toatsu Chemicals Inc. Preparation process of n-acylphenylalanines
JPS6354321A (en) 1985-03-27 1988-03-08 Ajinomoto Co Inc Blood sugar lowering agent
US4743547A (en) * 1985-04-09 1988-05-10 Kuraray Co., Ltd. Method of producing L-phenylalanine
EP0526171B1 (en) * 1991-07-30 1997-03-05 Ajinomoto Co., Inc. Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them
JP2969397B2 (en) * 1991-09-10 1999-11-02 花王株式会社 Method for producing N-long-chain acyl-β-alanine
JP3025725B2 (en) * 1992-11-24 2000-03-27 花王株式会社 Method for separating and purifying N-long-chain acylamino acids
JPH06256276A (en) * 1993-03-02 1994-09-13 Kao Corp Method for producing N-long chain acylamino acid salt
JPH0717899A (en) * 1993-07-01 1995-01-20 Ajinomoto Co Inc Production of carboxylic acid chloride
EP2277517A1 (en) 1996-11-15 2011-01-26 Ajinomoto Co., Inc. Nateglinide tablet composition
US6844006B1 (en) * 1999-07-09 2005-01-18 Pennfield Oil Company Process and apparatus for the preparation of chlortetracycline-containing animal feed compositions
AU2226901A (en) 1999-12-28 2001-07-09 Ajinomoto Co., Inc. Oral preparations for diabetes
EP1283054A4 (en) 2000-03-17 2006-04-12 Ajinomoto Kk Drugs for complications of diabetes and neuropathy and utilization thereof
ATE373635T1 (en) 2000-10-18 2007-10-15 Ajinomoto Kk METHOD FOR PRODUCING ACYLPHENYLALANINES
KR100819358B1 (en) 2000-10-18 2008-04-04 아지노모토 가부시키가이샤 Method for preparing nateglinide crystal
DK1334720T3 (en) 2000-10-24 2009-01-19 Ajinomoto Kk Nateglinide-containing preparations
WO2002034713A1 (en) 2000-10-24 2002-05-02 Ajinomoto Co.,Inc. Process for producing b-form nateglinide crystal

Also Published As

Publication number Publication date
CN1273442C (en) 2006-09-06
DE60130575D1 (en) 2007-10-31
KR100783306B1 (en) 2007-12-10
DE60130575T2 (en) 2008-04-30
JP4158192B2 (en) 2008-10-01
EP1334962A4 (en) 2005-08-24
EP1334962B1 (en) 2007-09-19
PT1334962E (en) 2007-10-09
US20040024219A1 (en) 2004-02-05
ES2290173T3 (en) 2008-02-16
ATE373635T1 (en) 2007-10-15
BR0114728B1 (en) 2014-01-14
MXPA03003483A (en) 2003-07-14
EP1334962A1 (en) 2003-08-13
RU2287520C2 (en) 2006-11-20
CA2425533C (en) 2010-04-20
US7659428B2 (en) 2010-02-09
CA2425533A1 (en) 2003-04-10
DK1334962T3 (en) 2007-12-10
CY1107502T1 (en) 2013-03-13
US20060155143A1 (en) 2006-07-13
JPWO2002032853A1 (en) 2004-02-26
TW575541B (en) 2004-02-11
US7030268B2 (en) 2006-04-18
BR0114728A (en) 2003-10-14
KR20030059202A (en) 2003-07-07
WO2002032853A1 (en) 2002-04-25
CN1481355A (en) 2004-03-10

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