[go: up one dir, main page]

AU2001293033A1 - Method of producing non-human mammals - Google Patents

Method of producing non-human mammals

Info

Publication number
AU2001293033A1
AU2001293033A1 AU2001293033A AU9303301A AU2001293033A1 AU 2001293033 A1 AU2001293033 A1 AU 2001293033A1 AU 2001293033 A AU2001293033 A AU 2001293033A AU 9303301 A AU9303301 A AU 9303301A AU 2001293033 A1 AU2001293033 A1 AU 2001293033A1
Authority
AU
Australia
Prior art keywords
human mammals
producing non
producing
mice
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293033A
Inventor
Kevin C. Eggan
Rudolf Jaenisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
Original Assignee
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Institute for Biomedical Research filed Critical Whitehead Institute for Biomedical Research
Publication of AU2001293033A1 publication Critical patent/AU2001293033A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Feed For Specific Animals (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A method of producing mutant/targeted non-human mammals, such as mutant mice that does not require production of chimera and permits the introduction of multiple mutations in embryos and, thus, avoids the necessity of breeding to combine all of the desired mutations in a single animal. The method is efficient in producing ES mice.
AU2001293033A 2000-09-20 2001-09-20 Method of producing non-human mammals Abandoned AU2001293033A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23437800P 2000-09-20 2000-09-20
US60/234,378 2000-09-20
US25597000P 2000-12-15 2000-12-15
US60/255,970 2000-12-15
US09/755,003 2001-01-05
US09/755,003 US6784336B2 (en) 2000-09-20 2001-01-05 Method of producing mutant mice
PCT/US2001/029864 WO2002023983A2 (en) 2000-09-20 2001-09-20 Method of producing non-human mammals

Publications (1)

Publication Number Publication Date
AU2001293033A1 true AU2001293033A1 (en) 2002-04-02

Family

ID=27398562

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293033A Abandoned AU2001293033A1 (en) 2000-09-20 2001-09-20 Method of producing non-human mammals

Country Status (7)

Country Link
US (5) US6784336B2 (en)
EP (1) EP1322151B1 (en)
AT (1) ATE377943T1 (en)
AU (1) AU2001293033A1 (en)
DE (1) DE60131429T2 (en)
DK (1) DK1322151T3 (en)
WO (1) WO2002023983A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6784336B2 (en) 2000-09-20 2004-08-31 Whitehead Institute For Biomedical Research Method of producing mutant mice
EP1527162A1 (en) * 2002-08-09 2005-05-04 Dr. H. Zech GmbH Method for producing cell lines and organs by means of differentiable cells
EP1639098A1 (en) * 2003-07-08 2006-03-29 McGill University Non-inbred embryonic stem cells having good developmental potential
SI1802193T1 (en) * 2004-10-19 2014-08-29 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
US8669048B2 (en) * 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
WO2015196072A2 (en) 2014-06-19 2015-12-23 Whitehead Institute For Biomedical Research Uses of kinase inhibitors for inducing and maintaining pluripotency
CA3026103A1 (en) 2016-06-10 2017-12-14 Saunders, Ann M. Methods for detecting structural variants in neurodegenerative disease
CN108070617A (en) * 2016-11-16 2018-05-25 中国科学院海洋研究所 A kind of exopalaemon carinicauda embryo micro-injection method and Application way structure mRNA are overexpressed model
CN111778287B (en) * 2020-04-30 2021-05-07 生物岛实验室 A kind of preparation method of chimeric embryo or animal
US12371667B2 (en) 2021-05-13 2025-07-29 Washington University Enhanced methods for inducing and maintaining naive human pluripotent stem cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
DE19632532A1 (en) * 1996-08-13 1998-02-19 Boehringer Ingelheim Int Process for the production of mammals with defined genetic properties
US6784336B2 (en) * 2000-09-20 2004-08-31 Whitehead Institute For Biomedical Research Method of producing mutant mice

Also Published As

Publication number Publication date
US20020078470A1 (en) 2002-06-20
WO2002023983A8 (en) 2002-07-11
DE60131429D1 (en) 2007-12-27
DE60131429T2 (en) 2008-09-18
WO2002023983A3 (en) 2002-10-17
DK1322151T3 (en) 2008-03-25
ATE377943T1 (en) 2007-11-15
US6784336B2 (en) 2004-08-31
EP1322151A2 (en) 2003-07-02
EP1322151B1 (en) 2007-11-14
WO2002023983A2 (en) 2002-03-28
US20040231014A1 (en) 2004-11-18
US20020062493A1 (en) 2002-05-23
US20110061119A1 (en) 2011-03-10
US20050081257A1 (en) 2005-04-14

Similar Documents

Publication Publication Date Title
AU2003258157A1 (en) Mutant e. coli appa phytase enzymes
AU2001293033A1 (en) Method of producing non-human mammals
AU2003303830A1 (en) Production of multimeric proteins
AU1909695A (en) Transgenic non-human mammals with progressive neurologic disease
PL328996A1 (en) Agent for increasing production of breed mammals
AU2001227760A1 (en) Methods and apparatus for producing animal sounds to lure animals
AU2003230454A1 (en) Pet's chew and manufacture process
AU4796099A (en) Fish feeding control in aquaculture on the basis of sound emitted by fish
PT928332E (en) PROCESS FOR THE PRODUCTION OF DEFINITIVE GENETIC PROPERTIES MAMMALS
NO20010523L (en) Method of feeding aquatic animals
WO2003096799A3 (en) Multiple closed nucleus breeding for swine production
PT944332E (en) FLOCULAR FOOD FOR AQUATIC ANIMALS AND PROCESS FOR THEIR PREPARATION
MXPA02008288A (en) Production of mammals which produce progeny of a single sex.
MXPA02004484A (en) Methods for sexing non human mammals.
EP0853122A3 (en) Transgenic animals lacking functional H2-M molecule
MXPA03003169A (en) Feed for bovine neonates breeding and its use.
WO2002041703A3 (en) Zeolite additive for animal feed and method of using same
NZ508602A (en) The production of primmorphs from disassociated cells of sponges, corals and other invertebrates, and use thereof
EP1375654A3 (en) Transgenic and cloned mammals
AU2002214050A1 (en) Feedstuff
AU1396401A (en) Zootechnical formulations comprising bile acids
EP1167532A3 (en) Edible transgenic plants expressing mammalian proteins
WO2002052930A3 (en) Control of sex determination in mammals
EP0977838A4 (en) H2-o modified transgenic animals
AU6292898A (en) Efficient nuclear transfer using primordial germ cells