[go: up one dir, main page]

AU2001289789A1 - Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts - Google Patents

Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts

Info

Publication number
AU2001289789A1
AU2001289789A1 AU2001289789A AU8978901A AU2001289789A1 AU 2001289789 A1 AU2001289789 A1 AU 2001289789A1 AU 2001289789 A AU2001289789 A AU 2001289789A AU 8978901 A AU8978901 A AU 8978901A AU 2001289789 A1 AU2001289789 A1 AU 2001289789A1
Authority
AU
Australia
Prior art keywords
pyrrolidine
protected
preparation
phosphonium salts
substituted phosphonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001289789A
Inventor
Mark Rogers-Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Publication of AU2001289789A1 publication Critical patent/AU2001289789A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for producing the compound (1'benzyl-2-oxo-[1,3']-(R)-bipyrrolidinyl-3-(R,S)-yl)-triphenyl-phosphonium bromide which is an intermediate for antibacterial vinylpyrrolidinone-cephalosporin derivatives.
AU2001289789A 2000-08-14 2001-08-06 Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts Abandoned AU2001289789A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00117525 2000-08-14
EP00117525 2000-08-14
PCT/EP2001/009059 WO2002014332A1 (en) 2000-08-14 2001-08-06 Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts

Publications (1)

Publication Number Publication Date
AU2001289789A1 true AU2001289789A1 (en) 2002-02-25

Family

ID=8169526

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001289789A Abandoned AU2001289789A1 (en) 2000-08-14 2001-08-06 Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts

Country Status (13)

Country Link
US (3) US6828442B2 (en)
EP (1) EP1311518B1 (en)
JP (1) JP3989832B2 (en)
KR (1) KR100698814B1 (en)
CN (1) CN1212327C (en)
AT (1) ATE308549T1 (en)
AU (1) AU2001289789A1 (en)
CA (1) CA2418970C (en)
DE (1) DE60114641T2 (en)
DK (1) DK1311518T3 (en)
ES (1) ES2251508T3 (en)
MX (1) MXPA03001310A (en)
WO (1) WO2002014332A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1212327C (en) * 2000-08-14 2005-07-27 巴斯利尔药物股份公司 Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts
JP2002212155A (en) * 2001-01-17 2002-07-31 Toray Ind Inc Optically active asparagine ester derivative, optically active 3-aminopyrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative
WO2010136422A1 (en) 2009-05-25 2010-12-02 Sandoz Ag Method for the production of ceftobiprole medocaril
CN111471058A (en) * 2019-01-23 2020-07-31 中国医学科学院药物研究所 Process for preparing cephapirin analogues

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ251896A3 (en) * 1995-09-12 1997-04-16 Hoffmann Ka Roche Ag F Cephalosporin derivatives
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
CN1212327C (en) * 2000-08-14 2005-07-27 巴斯利尔药物股份公司 Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts

Also Published As

Publication number Publication date
CA2418970C (en) 2011-03-22
DE60114641T2 (en) 2006-07-20
JP2004506642A (en) 2004-03-04
MXPA03001310A (en) 2003-06-30
EP1311518A1 (en) 2003-05-21
US7511154B2 (en) 2009-03-31
CA2418970A1 (en) 2002-02-21
ATE308549T1 (en) 2005-11-15
US6828442B2 (en) 2004-12-07
KR20030022395A (en) 2003-03-15
JP3989832B2 (en) 2007-10-10
DE60114641D1 (en) 2005-12-08
US20050070722A1 (en) 2005-03-31
ES2251508T3 (en) 2006-05-01
US20080009637A1 (en) 2008-01-10
US7262307B2 (en) 2007-08-28
US20030195364A1 (en) 2003-10-16
WO2002014332A1 (en) 2002-02-21
EP1311518B1 (en) 2005-11-02
CN1451012A (en) 2003-10-22
KR100698814B1 (en) 2007-03-23
DK1311518T3 (en) 2006-02-13
CN1212327C (en) 2005-07-27

Similar Documents

Publication Publication Date Title
AU2001277753A1 (en) Phosphonocephem compound
AU6530896A (en) Pyrrolidine derivatives having phospholipase a2 inhibitory activity
AU2002211216A1 (en) Substituted aminopropoxyaryl derivatives useful as agonists for lxr
MXPA02003977A (en) INHIBITORS OF agr;L.
TW334435B (en) Bicyclic amines
AU8991698A (en) Compounds for electronic devices
TW200738672A (en) Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
EP1380564A4 (en) Binaphtol derivative and process for producing the same
CA2354880A1 (en) Method for the preparation of citalopram
CA2149886A1 (en) Process for preparing tetrazolyl-benzopyranones
BG104447A (en) Biphenylamidine derivatives
CA2426680A1 (en) Process for formulation of antibiotic compounds
AU2001289789A1 (en) Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts
WO2002016322A3 (en) Process for the preparation of 2-aminoethylpyridines
EP1026162A4 (en) Antirheumatic
AU6578400A (en) Novel method for preparing benzoperhydroisoindole compounds
EP1043311A4 (en) Biphenylamidine derivatives
AU2002214325A1 (en) Process for producing carbapenem-type antibacterial
AU2002365378A1 (en) Process for preparing 3,3',6,6'-tetraalkyl-2,2'-biphenols and 3,3',6,6'-tetraalkyl-5,5'-dihalo-2,2'-biphenols
GC0000218A (en) New imidazole derivatives
ES2102295A1 (en) New n-benzoylmethyl substituted paroxetine derivatives
WO2005035528A3 (en) Triazole derivatives as antibacterial agents
AU3266893A (en) 3,4'-dideoxymycaminosyltylonolide derivative and production thereof
WO2001070744A3 (en) Process for the preparation of midazolam
CA2279796A1 (en) Process for the preparation of substituted pyridines