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AU2001287537A1 - Fv constructs with an influenceable affinity for substance that is to be linked - Google Patents

Fv constructs with an influenceable affinity for substance that is to be linked

Info

Publication number
AU2001287537A1
AU2001287537A1 AU2001287537A AU8753701A AU2001287537A1 AU 2001287537 A1 AU2001287537 A1 AU 2001287537A1 AU 2001287537 A AU2001287537 A AU 2001287537A AU 8753701 A AU8753701 A AU 8753701A AU 2001287537 A1 AU2001287537 A1 AU 2001287537A1
Authority
AU
Australia
Prior art keywords
constructs
linked
affinity
substance
influenceable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001287537A
Inventor
Stefan Dubel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Heidelberg
Original Assignee
Universitaet Heidelberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10044002A external-priority patent/DE10044002A1/en
Application filed by Universitaet Heidelberg filed Critical Universitaet Heidelberg
Publication of AU2001287537A1 publication Critical patent/AU2001287537A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

The present invention relates to Fv constructs having an affinity that can be influenced for a substance to be linked, wherein the Fv constructs have peptides linked to the variable regions and containing binding sites for effector molecules. The invention also relates to a method of producing a single-chain Fv construct and the use of an Fv construct according to the invention for enriching and purifying substances.
AU2001287537A 2000-08-11 2001-08-10 Fv constructs with an influenceable affinity for substance that is to be linked Abandoned AU2001287537A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10040046 2000-08-11
DE10040046 2000-08-11
DE10044002A DE10044002A1 (en) 2000-08-11 2000-09-05 F¶v¶ constructs with influenceable affinity for a substance to be bound
DE10044002 2000-09-05
PCT/DE2001/003098 WO2002014371A1 (en) 2000-08-11 2001-08-10 Fv constructs with an influenceable affinity for a substance that is to be linked

Publications (1)

Publication Number Publication Date
AU2001287537A1 true AU2001287537A1 (en) 2002-02-25

Family

ID=26006714

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001287537A Abandoned AU2001287537A1 (en) 2000-08-11 2001-08-10 Fv constructs with an influenceable affinity for substance that is to be linked

Country Status (6)

Country Link
US (1) US20050054000A1 (en)
EP (1) EP1307490B1 (en)
AT (1) ATE360035T1 (en)
AU (1) AU2001287537A1 (en)
DE (1) DE50112379D1 (en)
WO (1) WO2002014371A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
HUE026303T2 (en) * 2005-07-25 2016-06-28 Emergent Product Dev Seattle B-cell reduction using CD37-specific and CD20-specific binding molecules
CN105837690A (en) * 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 Single-chain multivalent binding proteins with effector function
JP2010532764A (en) * 2007-07-06 2010-10-14 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド Binding peptide having a specific binding domain located at the C-terminus
AU2009234277B2 (en) * 2008-04-11 2014-12-04 Aptevo Research And Development Llc CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
US8647829B2 (en) * 2009-02-20 2014-02-11 General Electric Company Switchable affinity binders
WO2017053469A2 (en) 2015-09-21 2017-03-30 Aptevo Research And Development Llc Cd3 binding polypeptides
ES2708657T3 (en) 2016-07-29 2019-04-10 Miltenyi Biotec Gmbh Composition and method to affect the binding of antigen-binding polypeptides to antigens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075010A (en) * 1992-06-09 2000-06-13 Neorx Corporation Small molecular weight ligand-hexose containing clearing agents
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
US5439829A (en) * 1991-01-30 1995-08-08 Eli Lilly And Company Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
DK0827966T3 (en) * 1996-09-09 2002-05-21 Rmf Dictagene Sa Preparation of purified (poly) peptides

Also Published As

Publication number Publication date
EP1307490B1 (en) 2007-04-18
US20050054000A1 (en) 2005-03-10
EP1307490A1 (en) 2003-05-07
WO2002014371A1 (en) 2002-02-21
ATE360035T1 (en) 2007-05-15
DE50112379D1 (en) 2007-05-31

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