[go: up one dir, main page]

AU2001280796A1 - Electrowetting-driven micropumping - Google Patents

Electrowetting-driven micropumping

Info

Publication number
AU2001280796A1
AU2001280796A1 AU2001280796A AU8079601A AU2001280796A1 AU 2001280796 A1 AU2001280796 A1 AU 2001280796A1 AU 2001280796 A AU2001280796 A AU 2001280796A AU 8079601 A AU8079601 A AU 8079601A AU 2001280796 A1 AU2001280796 A1 AU 2001280796A1
Authority
AU
Australia
Prior art keywords
electrowetting
driven micropumping
micropumping
driven
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001280796A
Inventor
Chang-Jin Kim
Jung-Hoon Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Berkeley filed Critical University of California
Publication of AU2001280796A1 publication Critical patent/AU2001280796A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/004—Optical devices or arrangements for the control of light using movable or deformable optical elements based on a displacement or a deformation of a fluid
    • G02B26/005—Optical devices or arrangements for the control of light using movable or deformable optical elements based on a displacement or a deformation of a fluid based on electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AU2001280796A 2000-07-25 2001-07-25 Electrowetting-driven micropumping Abandoned AU2001280796A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22080300P 2000-07-25 2000-07-25
US60220803 2000-07-25
PCT/US2001/023506 WO2002007503A1 (en) 2000-07-25 2001-07-25 Electrowetting-driven micropumping

Publications (1)

Publication Number Publication Date
AU2001280796A1 true AU2001280796A1 (en) 2002-02-05

Family

ID=22825046

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001280796A Abandoned AU2001280796A1 (en) 2000-07-25 2001-07-25 Electrowetting-driven micropumping

Country Status (3)

Country Link
US (1) US8529743B2 (en)
AU (1) AU2001280796A1 (en)
WO (1) WO2002007503A1 (en)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1450956A2 (en) 2001-11-26 2004-09-01 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US6989234B2 (en) * 2002-09-24 2006-01-24 Duke University Method and apparatus for non-contact electrostatic actuation of droplets
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
JP2006525779A (en) * 2003-04-29 2006-11-09 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ Small motor for optical equipment by electrowetting method
US20110095201A1 (en) * 2003-08-22 2011-04-28 Stolowitz Mark L Electrowetting sample presentation device for matrix-assisted laser desorption/ionization mass spectrometry and related methods
DE102004007274A1 (en) 2004-02-14 2005-09-15 Roche Diagnostics Gmbh Test element for a human or animal fluid sample, e.g. to test for glucose, has a sampling surface and an actuator field to pull the sample to a test field
DE102004008685A1 (en) * 2004-02-21 2005-09-29 Roche Diagnostics Gmbh Transmission spectrometer for the examination of a liquid sample
BRPI0508528B8 (en) 2004-03-06 2021-06-22 Hoffmann La Roche device for sampling a body fluid and system for analyzing a body fluid
US7819822B2 (en) 2004-03-06 2010-10-26 Roche Diagnostics Operations, Inc. Body fluid sampling device
JP4595368B2 (en) * 2004-03-31 2010-12-08 ブラザー工業株式会社 Internal pressure stabilization device and ink tank
US20090215192A1 (en) * 2004-05-27 2009-08-27 Stratos Biosystems, Llc Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution
FR2871076A1 (en) * 2004-06-04 2005-12-09 Univ Lille Sciences Tech DEVICE FOR LASER RADIATION DESORPTION INCORPORATING HANDLING OF THE LIQUID SAMPLE IN THE FORM OF INDIVIDUAL DROPS ENABLING THEIR CHEMICAL AND BIOCHEMICAL TREATMENT
US20080135411A1 (en) * 2004-06-16 2008-06-12 Whitehead Lorne A Microfluidic Transport By Electrostatic Deformation of Fluidic Interfaces
JP4539213B2 (en) 2004-07-27 2010-09-08 ブラザー工業株式会社 Liquid transfer device
ATE485888T1 (en) 2004-08-26 2010-11-15 Life Technologies Corp ELECTROWETTING DEVICES AND ASSOCIATED METHODS
WO2006044966A1 (en) * 2004-10-18 2006-04-27 Stratos Biosystems, Llc Single-sided apparatus for manipulating droplets by electrowetting-on-dielectric techniques
US20060153745A1 (en) * 2005-01-11 2006-07-13 Applera Corporation Fluid processing device for oligonucleotide synthesis and analysis
EP1859330B1 (en) 2005-01-28 2012-07-04 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US7454988B2 (en) * 2005-02-10 2008-11-25 Applera Corporation Method for fluid sampling using electrically controlled droplets
EP1877334A4 (en) * 2005-04-25 2011-05-04 Agency Science Tech & Res SYSTEMS AND METHODS FOR PUMPING CONTINUOUS LIQUID COLUMNS USING HYDROPHOBICITY CONTROL ELEMENTS IN A MICROCANAL
EP1885885A4 (en) 2005-05-11 2008-08-27 Nanolytics Inc METHOD AND DEVICE FOR EXECUTING BIOCHEMICAL OR CHEMICAL REACTIONS AT SEVERAL TEMPERATURES
US8092664B2 (en) 2005-05-13 2012-01-10 Applied Biosystems Llc Electrowetting-based valving and pumping systems
US20060260919A1 (en) * 2005-05-17 2006-11-23 Marco Aimi Methods and apparatus for filling a microswitch with liquid metal
FR2887305B1 (en) * 2005-06-17 2011-05-27 Commissariat Energie Atomique DEVICE FOR PUMPING BY ELECTROWETTING AND APPLICATION TO MEASUREMENTS OF ELECTRIC ACTIVITY
DE602006006510D1 (en) 2005-08-30 2009-06-10 Brother Ind Ltd Device and head for conveying liquid
US7271688B1 (en) * 2005-09-30 2007-09-18 Agilent Technologies, Inc. Three-stage liquid metal switch
JP4774977B2 (en) 2005-12-19 2011-09-21 ブラザー工業株式会社 Liquid transfer device
US20090093735A1 (en) * 2006-03-29 2009-04-09 Stephan Korner Test unit and test system for analyzing body fluids
US8492168B2 (en) * 2006-04-18 2013-07-23 Advanced Liquid Logic Inc. Droplet-based affinity assays
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8637317B2 (en) * 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
US8613889B2 (en) * 2006-04-13 2013-12-24 Advanced Liquid Logic, Inc. Droplet-based washing
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US7815871B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet microactuator system
US7727723B2 (en) 2006-04-18 2010-06-01 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
WO2007123908A2 (en) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US8470606B2 (en) * 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US8927296B2 (en) 2006-04-18 2015-01-06 Advanced Liquid Logic, Inc. Method of reducing liquid volume surrounding beads
US8980198B2 (en) 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7816121B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet actuation system and method
US7763471B2 (en) * 2006-04-18 2010-07-27 Advanced Liquid Logic, Inc. Method of electrowetting droplet operations for protein crystallization
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
WO2009052348A2 (en) * 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Manipulation of beads in droplets
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7939021B2 (en) * 2007-05-09 2011-05-10 Advanced Liquid Logic, Inc. Droplet actuator analyzer with cartridge
US7822510B2 (en) * 2006-05-09 2010-10-26 Advanced Liquid Logic, Inc. Systems, methods, and products for graphically illustrating and controlling a droplet actuator
US8041463B2 (en) * 2006-05-09 2011-10-18 Advanced Liquid Logic, Inc. Modular droplet actuator drive
WO2009111769A2 (en) 2008-03-07 2009-09-11 Advanced Liquid Logic, Inc. Reagent and sample preparation and loading on a fluidic device
WO2007133714A2 (en) * 2006-05-12 2007-11-22 Stratos Biosystems, Llc Analyte focusing biochips for affinity mass spectrometry
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
ES2423930T3 (en) 2007-02-09 2013-09-25 Advanced Liquid Logic, Inc. Droplet actuator devices and methods using magnetic beads
US8872527B2 (en) 2007-02-15 2014-10-28 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
US8202686B2 (en) 2007-03-22 2012-06-19 Advanced Liquid Logic, Inc. Enzyme assays for a droplet actuator
US8440392B2 (en) 2007-03-22 2013-05-14 Advanced Liquid Logic Inc. Method of conducting a droplet based enzymatic assay
TWI322032B (en) * 2007-06-20 2010-03-21 Nat Univ Chung Cheng Microfluid mixer
US8951732B2 (en) 2007-06-22 2015-02-10 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
WO2009032863A2 (en) 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
NL1036211A1 (en) * 2007-12-03 2009-06-04 Asml Netherlands Bv Lithographic Apparatus and Device Manufacturing Method.
NL1036186A1 (en) * 2007-12-03 2009-06-04 Asml Netherlands Bv Lithographic apparatus and device manufacturing method.
EP2237955A4 (en) 2007-12-23 2016-04-20 Advanced Liquid Logic Inc Droplet actuator configurations and methods of conducting droplet operations
US9206794B2 (en) 2008-04-28 2015-12-08 Nxp, B.V. Microfluidic pump with metal electrode having variable oxidation state
WO2009137415A2 (en) 2008-05-03 2009-11-12 Advanced Liquid Logic, Inc. Reagent and sample preparation, loading, and storage
US8093064B2 (en) * 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
KR100993810B1 (en) 2008-09-30 2010-11-12 고려대학교 산학협력단 Digital micropump using electrowetting phenomenon over dielectric
FR2937690B1 (en) 2008-10-28 2010-12-31 Commissariat Energie Atomique DROP ACTUATED MICROPHONE
US8877512B2 (en) 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) * 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
EP2516669B1 (en) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
WO2011126892A2 (en) 2010-03-30 2011-10-13 Advanced Liquid Logic, Inc. Droplet operations platform
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US9371598B2 (en) 2010-04-05 2016-06-21 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9011662B2 (en) 2010-06-30 2015-04-21 Advanced Liquid Logic, Inc. Droplet actuator assemblies and methods of making same
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9188615B2 (en) 2011-05-09 2015-11-17 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
CN103597356A (en) 2011-05-10 2014-02-19 先进流体逻辑公司 Enzyme Concentration and Analysis
AU2012279420A1 (en) 2011-07-06 2014-01-30 Advanced Liquid Logic Inc Reagent storage on a droplet actuator
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
KR20130009504A (en) 2011-07-15 2013-01-23 삼성전자주식회사 Aperture adjustment method and aperture adjustment element
WO2013016413A2 (en) 2011-07-25 2013-01-31 Advanced Liquid Logic Inc Droplet actuator apparatus and system
FR2982176B1 (en) * 2011-11-09 2014-01-10 Commissariat Energie Atomique DEVICE AND METHOD FOR HANDLING DROPS
WO2013078216A1 (en) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Glucose-6-phosphate dehydrogenase assays
US20130161193A1 (en) * 2011-12-21 2013-06-27 Sharp Kabushiki Kaisha Microfluidic system with metered fluid loading system for microfluidic device
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
CA2877950C (en) 2012-06-27 2021-06-22 Advanced Liquid Logic Inc. Techniques and droplet actuator designs for reducing bubble formation
US9863913B2 (en) 2012-10-15 2018-01-09 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
EP3511423B2 (en) 2012-10-17 2024-05-29 Spatial Transcriptomics AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
LT3013983T (en) 2013-06-25 2023-05-10 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
EP3033599A4 (en) 2013-08-13 2017-03-22 Advanced Liquid Logic, Inc. Methods of improving accuracy and precision of droplet metering using an on-actuator reservoir as the fluid input
KR20160081896A (en) 2013-08-30 2016-07-08 일루미나, 인코포레이티드 Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
WO2015168161A2 (en) 2014-04-29 2015-11-05 Illumina, Inc. Multiplexed single cell gene expression analysis using template switch and tagmentation
BR112017005038B1 (en) 2014-10-09 2022-01-25 Illumina, Inc Method and device for separating immiscible liquids to effectively isolate at least one of the liquids
CN104614853B (en) * 2015-01-27 2017-11-10 华南师范大学 Electrowetting substrate and preparation method thereof, Electrowetting module
EP3725893A1 (en) 2015-02-10 2020-10-21 Illumina, Inc. Compositions for analyzing cellular components
EP3271073B1 (en) 2015-03-20 2019-06-12 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
SG11201707515SA (en) 2015-04-10 2017-10-30 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US10723988B2 (en) 2015-04-22 2020-07-28 Berkeley Lights, Inc. Microfluidic cell culture
ES2826880T3 (en) 2015-05-11 2021-05-19 Illumina Inc Platform for the discovery and analysis of therapeutic agents
US10857537B2 (en) 2015-07-06 2020-12-08 Illumina, Inc. Balanced AC modulation for driving droplet operations electrodes
IL295355B2 (en) 2015-08-14 2023-11-01 Illumina Inc System and methods for determining genetic characteristics using magnetically responsive sensors
ES2988429T3 (en) 2015-08-28 2024-11-20 Illumina Inc Single cell nucleic acid sequence analysis
CN107921432A (en) 2015-09-02 2018-04-17 伊卢米纳剑桥有限公司 Improve the system and method for the droplet manipulation in flow control system
US20190217300A1 (en) 2015-10-22 2019-07-18 Illumina, Inc. Filler fluid for fluidic devices
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
WO2017095845A1 (en) 2015-12-01 2017-06-08 Illumina, Inc. Liquid storage and delivery mechanisms and methods
CA3006985C (en) * 2015-12-01 2021-11-09 Illumina, Inc. Digital microfluidic system for single-cell isolation and characterization of analytes
CN109073518B (en) 2016-04-01 2020-02-28 多伦多大学管理委员会 DMF method and system for concentrating analytes from large volumes to smaller volumes using magnetic particles
CN109312396A (en) 2016-04-07 2019-02-05 伊鲁米那股份有限公司 Methods and systems for constructing standardized nucleic acid libraries
SG11201809539RA (en) 2016-05-26 2018-12-28 Berkeley Lights Inc Covalently modified surfaces, kits, and methods of preparation and use
WO2018049399A1 (en) * 2016-09-12 2018-03-15 Commscope Technologies Llc Active optical switch system with anti-wetting coating
TWI691361B (en) 2017-10-18 2020-04-21 美商電子墨水股份有限公司 Digital microfluidic devices including dual substrates with thin-film transistors and capacitive sensing
US11905553B2 (en) 2018-01-29 2024-02-20 St. Jude Children's Research Hospital, Inc. Method for nucleic acid amplification
US11353759B2 (en) 2018-09-17 2022-06-07 Nuclera Nucleics Ltd. Backplanes with hexagonal and triangular electrodes
TWI730448B (en) 2018-10-15 2021-06-11 美商電子墨水股份有限公司 Digital microfluidic delivery device
EP3924513B1 (en) 2019-02-14 2023-04-12 Pacific Biosciences of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
CN110755699A (en) * 2019-09-18 2020-02-07 浙江省北大信息技术高等研究院 Implantable Electroosmotic Micropump Device
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
WO2021102134A1 (en) 2019-11-20 2021-05-27 E Ink Corporation Spatially variable hydrophobic layers for digital microfluidics
CN114945426A (en) 2020-01-17 2022-08-26 核酸有限公司 Spatially variable dielectric layer for digital microfluidics
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11946901B2 (en) 2020-01-27 2024-04-02 Nuclera Ltd Method for degassing liquid droplets by electrical actuation at higher temperatures
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11410620B2 (en) 2020-02-18 2022-08-09 Nuclera Nucleics Ltd. Adaptive gate driving for high frequency AC driving of EWoD arrays
JP2023514278A (en) 2020-02-19 2023-04-05 ヌークレラ ヌクリークス， リミテッド Latched Transistor Drive for High Frequency AC Drive of EWoD Arrays
EP4142942A4 (en) 2020-04-27 2024-05-22 Nuclera Ltd Segmented top plate for variable driving and short protection for digital microfluidics
EP4153984A1 (en) 2020-05-19 2023-03-29 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
ES2989052T3 (en) 2020-05-22 2024-11-25 10X Genomics Inc Simultaneous spatiotemporal measurement of gene expression and cellular activity
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
ES2993269T3 (en) 2020-09-18 2024-12-26 10X Genomics Inc Sample handling apparatus and image registration methods
WO2022074399A1 (en) 2020-10-08 2022-04-14 Nuclera Nucleics Ltd Electrowetting system and method for reagent-specific driving ewod arrays in microfluidic systems
CN116635153A (en) 2020-11-04 2023-08-22 核蛋白有限公司 Dielectric layer for digital microfluidic devices
EP4421491A3 (en) 2021-02-19 2024-11-27 10X Genomics, Inc. Method of using a modular assay support device
USD1064308S1 (en) 2021-09-17 2025-02-25 10X Genomics, Inc. Sample handling device
DE102021213270A1 (en) 2021-11-25 2023-05-25 Robert Bosch Gesellschaft mit beschränkter Haftung media output device
WO2023122033A1 (en) 2021-12-20 2023-06-29 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
CN115337968B (en) * 2022-08-13 2023-08-18 兰州大学 Semi-closed digital micro-fluidic system based on SLIPS insulating hydrophobic film
US20250060333A1 (en) 2023-08-16 2025-02-20 E Ink Corporation Devices, methods, and systems for visualizing electrowetting pathing using electrophoretic materials

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872480A (en) * 1974-03-14 1975-03-18 Rca Corp Method of electrostatic recording on electrically insulating films by non-wetting electrically conductive liquids
US3934180A (en) * 1974-08-12 1976-01-20 Rca Corporation Method of reproducing an electrostatic charge pattern in intensified form
US4390403A (en) * 1981-07-24 1983-06-28 Batchelder J Samuel Method and apparatus for dielectrophoretic manipulation of chemical species
FR2543320B1 (en) * 1983-03-23 1986-01-31 Thomson Csf INDICATOR DEVICE WITH ELECTRICALLY CONTROLLED MOVEMENT OF A FLUID
FR2548795B1 (en) * 1983-07-04 1986-11-21 Thomson Csf OPTICAL SWITCHING DEVICE WITH FLUID DISPLACEMENT AND DEVICE FOR COMPOSING A POINT LINE
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4742345A (en) * 1985-11-19 1988-05-03 Copytele, Inc. Electrophoretic display panel apparatus and methods therefor
US5181016A (en) * 1991-01-15 1993-01-19 The United States Of America As Represented By The United States Department Of Energy Micro-valve pump light valve display
WO1993010163A2 (en) * 1991-11-12 1993-05-27 Nepera, Inc. Adhesive hydrogels having extended use lives and process for the preparation of same
US5757345A (en) * 1996-05-06 1998-05-26 Xerox Corportion Electrocapillary color display sheet
US5808593A (en) * 1996-06-03 1998-09-15 Xerox Corporation Electrocapillary color display sheet
US6379929B1 (en) * 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
US5929960A (en) * 1997-10-17 1999-07-27 Kent State University Method for forming liquid crystal display cell walls using a patterned electric field
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US7167156B1 (en) * 1999-02-26 2007-01-23 Micron Technology, Inc. Electrowetting display
JP2002162652A (en) * 2000-01-31 2002-06-07 Fujitsu Ltd Sheet display device, resin spherical body, and microcapsule
US6924792B1 (en) * 2000-03-10 2005-08-02 Richard V. Jessop Electrowetting and electrostatic screen display systems, colour displays and transmission means
US6773566B2 (en) 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
US6897848B2 (en) * 2001-01-11 2005-05-24 Xerox Corporation Rotating element sheet material and stylus with gradient field addressing
WO2002069016A2 (en) * 2001-02-28 2002-09-06 Lightwave Microsystems Corporation Microfluid control for waveguide optical switches, variable attenuators, and other optical devices
US6600888B2 (en) * 2001-11-02 2003-07-29 Xerox Corporation Liquid charging method and apparatus
EP1450956A2 (en) 2001-11-26 2004-09-01 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6989234B2 (en) * 2002-09-24 2006-01-24 Duke University Method and apparatus for non-contact electrostatic actuation of droplets
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
JP2007147321A (en) * 2005-11-24 2007-06-14 Toshiba Corp Liquid level detection structure

Also Published As

Publication number Publication date
US8529743B2 (en) 2013-09-10
WO2002007503A1 (en) 2002-01-31
US20030205632A1 (en) 2003-11-06

Similar Documents

Publication Publication Date Title
AU2001280796A1 (en) Electrowetting-driven micropumping
AU2001262847A1 (en) Language-understanding
AU2001228708A1 (en) Coin-validation arrangement
AU2001292739A1 (en) 1-oxorapamycins
AU2002211620A1 (en) Autoanastomosis
AU2001254546A1 (en) Aminopiperidines
AU2000267458A1 (en) Hypercomputer
AU2001239310A1 (en) Decahydro-isoquinolines
AU2001296577A1 (en) Chlorophyllases
AU2001258349A1 (en) Bisacylguanidine
AU2001279754A1 (en) Indoloquinazolinones
AU2002211128A1 (en) Step-bike
AU2001290931A1 (en) Ski-snowboard
AU2001285886A1 (en) 2-guanidino-4-aryl-quinazoline
AU2001258924A1 (en) Microsatellite-aflp
AU2001293852A1 (en) Sulfonylguanidine
AU2002226346A1 (en) 2-aryl-5-trifluoromethylpyridines
AU2001291876A1 (en) Triazolo-epothilones
AU2001246864A1 (en) Hypotensors
AU2001226668A1 (en) Crankshaft-starter-generator
AU2002214354A1 (en) Neck-phone
AU2001260192A1 (en) Glycinamides
AU2001295713A1 (en) Blast-processing
AU2001262711A1 (en) Cytoprotectors
AU5018801A (en) Offside-detection-system