[go: up one dir, main page]

AU2001278986A1 - 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors - Google Patents

3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors

Info

Publication number
AU2001278986A1
AU2001278986A1 AU2001278986A AU7898601A AU2001278986A1 AU 2001278986 A1 AU2001278986 A1 AU 2001278986A1 AU 2001278986 A AU2001278986 A AU 2001278986A AU 7898601 A AU7898601 A AU 7898601A AU 2001278986 A1 AU2001278986 A1 AU 2001278986A1
Authority
AU
Australia
Prior art keywords
aminocarbonyloxy
alpha
phenyl
amino
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278986A
Inventor
Susan Ashwell
Darren B. Dressen
Francine S. Grant
Andrei W. Konradi
Anthony Kreft
Michael A Pleiss
Dimitrios Sarantakis
Eugene D. Thorsett
Gregory S. Welmaker
Ying-Zi Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC, American Home Products Corp filed Critical Elan Pharmaceuticals LLC
Publication of AU2001278986A1 publication Critical patent/AU2001278986A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001278986A 2000-07-21 2001-07-20 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors Abandoned AU2001278986A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22013400P 2000-07-21 2000-07-21
US60220134 2000-07-21
PCT/US2001/023073 WO2002008206A1 (en) 2000-07-21 2001-07-20 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors

Publications (1)

Publication Number Publication Date
AU2001278986A1 true AU2001278986A1 (en) 2002-02-05

Family

ID=22822211

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001278986A Abandoned AU2001278986A1 (en) 2000-07-21 2001-07-20 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors

Country Status (3)

Country Link
US (2) US6689781B2 (en)
AU (1) AU2001278986A1 (en)
WO (1) WO2002008206A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143929A0 (en) * 1999-01-22 2002-04-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
KR101011373B1 (en) 2002-07-11 2011-01-28 비큐론 파마슈티컬스 인코포레이티드 N-hydroxyamide derivative having antibacterial activity
JP2004189780A (en) 2002-12-06 2004-07-08 Kansai Paint Co Ltd Method for color matching of bright coating
EP1633731A2 (en) * 2003-05-20 2006-03-15 Genentech, Inc. Thiocarbamate inhibitors of alpha-4 integrins
WO2005030735A1 (en) * 2003-09-25 2005-04-07 Ranbaxy Laboratories Limited Triazines derivatives as cell adhesion inhibitors
ATE502031T1 (en) 2005-09-29 2011-04-15 Elan Pharm Inc CARBAMAT COMPOUNDS THAT INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
NZ567270A (en) * 2005-09-29 2011-06-30 Elan Pharm Inc Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1984344B1 (en) 2005-12-29 2012-09-26 Lexicon Pharmaceuticals, Inc. Multicyclic amino acid derivatives and methods of their use
JP5135235B2 (en) * 2006-02-27 2013-02-06 エラン ファーマシューティカルズ，インコーポレイテッド Pyrimidinylsulfonamide compounds that inhibit leukocyte adhesion mediated by VAL-4
CA2714335A1 (en) 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
EP2860260A1 (en) 2008-04-11 2015-04-15 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
KR20110112301A (en) 2008-11-18 2011-10-12 메리맥 파마슈티컬즈, 인크. Human Serum Albumin Linker and Conjugates thereof
MX2011011326A (en) * 2009-04-27 2012-02-13 Elan Pharm Inc Pyridinone antagonists of alpha-4 integrins.
CA2850885A1 (en) 2011-10-17 2013-04-25 Westfaelische Wilhelms-Universitaet Muenster Assessment of pml risk and methods based thereon
WO2014036520A1 (en) 2012-08-30 2014-03-06 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
KR20170052526A (en) 2014-03-13 2017-05-12 프로테나 바이오사이언시즈 리미티드 Combination treatment for multiple sclerosis
JP7189369B2 (en) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド Compounds for inhibition of alpha4beta7 integrin
JP7189368B2 (en) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド Compounds for inhibition of alpha4beta7 integrin
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
CN119462635A (en) 2018-10-30 2025-02-18 吉利德科学公司 Quinoline derivatives as α4β7 integrin inhibitors
WO2020112773A1 (en) * 2018-11-27 2020-06-04 The General Hospital Corporation Targeting intraepithelial lymphocytes for treatment of metabolic syndrome
KR20220047323A (en) 2019-08-14 2022-04-15 길리애드 사이언시즈, 인코포레이티드 Compounds for Inhibiting Alpha 4 Beta 7 Integrin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8661298A (en) * 1997-07-31 1999-02-22 American Home Products Corporation Dipeptide compounds which inhibit leukocyte adhesion mediated by VLA-4
WO1999043642A1 (en) 1998-02-26 1999-09-02 Celltech Therapeutics Limited Phenylalanine derivatives as inhibitors of alpha4 integrins

Also Published As

Publication number Publication date
US7291645B2 (en) 2007-11-06
WO2002008206A1 (en) 2002-01-31
US6689781B2 (en) 2004-02-10
US20020055509A1 (en) 2002-05-09
US20040127486A1 (en) 2004-07-01

Similar Documents

Publication Publication Date Title
AU2001278986A1 (en) 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors
IL181957A0 (en) Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
AU2002244638A1 (en) Fumaric acid derivatives as NF-kappaB inhibitors
AU2002333524A1 (en) Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
AU2002216028A1 (en) Novel carbamate-substituted pyrazolopyridine derivatives
AU2001265111A1 (en) Benzenedicarboxylic acid derivatives
AU2002222574A1 (en) Substituted carboxylic acid derivatives
AU2002222552A1 (en) Substituted carboxylic acid derivatives
AU2001280167A1 (en) Novel propenohydroxamic acid derivatives
AU1597201A (en) Pyrrolecarbonylimino derivatives as naaladase inhibitors
AU2001270200A1 (en) Fatty acid synthase inhibitors
AU2199401A (en) Propanoic acid derivatives as integrin inhibitors
AU2690600A (en) 2-mercaptocarboxylic acid derivatives
AU7961300A (en) Kainic acid neurocytotoxicity inhibitors
AU2001281059A1 (en) Fatty acid synthase inhibitors
AU2002241211A1 (en) Imidazo-triazine derivatives as pde 5 inhibitors
AU2002350942A1 (en) Imidazolidineacetic acid derivatives
AU2001244671A1 (en) Quinolonecarboxylic acid derivative
AU2002222573A1 (en) Substituted carboxylic acid derivatives
AU2002239438A1 (en) 2,4-hexadienoic acid and derivatives as corrosion inhibitors
AU1303201A (en) Alkoxyiminoalkanoic acid derivatives
AU2002222550A1 (en) Substituted carboxylic acid derivatives
AU2001255408A1 (en) Tetrahydro-azepinone derivatives as thrombin inhibitors
AU2001271531A1 (en) Fatty acid synthase inhibitors
AUPQ365299A0 (en) Anthranilic acid derivatives