[go: up one dir, main page]

AU2001276022A1 - Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4 - Google Patents

Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4

Info

Publication number
AU2001276022A1
AU2001276022A1 AU2001276022A AU7602201A AU2001276022A1 AU 2001276022 A1 AU2001276022 A1 AU 2001276022A1 AU 2001276022 A AU2001276022 A AU 2001276022A AU 7602201 A AU7602201 A AU 7602201A AU 2001276022 A1 AU2001276022 A1 AU 2001276022A1
Authority
AU
Australia
Prior art keywords
vla
inhibitors
beta
amino acid
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001276022A
Other languages
English (en)
Inventor
Susan Ashwell
Darren B. Dressen
Francine S. Grant
Andrei W. Konradi
Anthony Kreft
Michael A Pleiss
Dimitrios Sarantakis
Christopher Semko
Frank Stappenbeck
Eugene D. Thorsett
Gregory S. Welmaker
Ying-Zi Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22822136&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001276022(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Elan Pharmaceuticals LLC, American Home Products Corp filed Critical Elan Pharmaceuticals LLC
Publication of AU2001276022A1 publication Critical patent/AU2001276022A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2001276022A 2000-07-21 2001-07-20 Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4 Abandoned AU2001276022A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22011800P 2000-07-21 2000-07-21
US60220118 2000-07-21
PCT/US2001/023071 WO2002008201A2 (en) 2000-07-21 2001-07-20 Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
AU2001276022A1 true AU2001276022A1 (en) 2002-02-05

Family

ID=22822136

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001276022A Abandoned AU2001276022A1 (en) 2000-07-21 2001-07-20 Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4

Country Status (4)

Country Link
US (2) US6953802B2 (es)
AU (1) AU2001276022A1 (es)
PE (1) PE20020384A1 (es)
WO (1) WO2002008201A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
WO2005000246A2 (en) * 2003-06-25 2005-01-06 Elan Pharmaceuticals, Inc. Methods and compositions for treating rheumatoid arthritis
DE602005009252D1 (de) * 2004-12-08 2008-10-02 Bristol Myers Squibb Co Heterocyclische verbindungen als inhibitoren von faktor viia
TWI389904B (zh) 2006-02-27 2013-03-21 Elan Pharm Inc 抑制由ｖｌａ-４所調節的白血球黏附之嘧啶磺醯胺化合物
US20080319652A1 (en) * 2007-06-20 2008-12-25 Radiofy Llc Navigation system and methods for map navigation
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
JP7189368B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド アルファ４ベータ７インテグリンの阻害のための化合物
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
KR102630416B1 (ko) 2018-10-30 2024-02-01 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
CN114222730B (zh) 2019-08-14 2024-09-10 吉利德科学公司 用于抑制α4β7整合素的化合物
US20240301512A1 (en) 2021-01-29 2024-09-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330506A3 (en) 1988-02-26 1990-06-20 Dana Farber Cancer Institute Vla proteins
US5510332A (en) 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
ATE237342T1 (de) 1994-07-11 2003-05-15 Athena Neurosciences Inc Inhibitoren der leukozytenadhäsion

Also Published As

Publication number Publication date
PE20020384A1 (es) 2002-05-28
US20050192280A1 (en) 2005-09-01
US7223762B2 (en) 2007-05-29
US20020058664A1 (en) 2002-05-16
WO2002008201A2 (en) 2002-01-31
US6953802B2 (en) 2005-10-11
WO2002008201A3 (en) 2002-06-27

Similar Documents

Publication Publication Date Title
AU2623900A (en) Compounds which inhibit leukocyte adhesion mediated by vla-4
AU2001276022A1 (en) Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4
AU2003229033A1 (en) Acrylic structural adhesive having improved t-peel strength
AU2002243328A1 (en) Modified rubber-based adhesives
AU2003256329A1 (en) Use of adhesion molecules as bond stress-enhanced nanoscale binding switches
AU2003235248A1 (en) Hyaluronic acid modification product
AU2003265235A1 (en) Non-affinity purification of proteins
AU2003223188A1 (en) Adhesives
AU2003206689A1 (en) Radiation-hardened coatings with improved adhesive strength
AU3348800A (en) Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4
AU2001277960A1 (en) 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by vla-4
AU2002307432A1 (en) Production of alpha-lipoic acid
IL165077A0 (en) Inectable solid hyaluronic acid carriers for delivery of osteogenic proteins
AU2001282938A1 (en) Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by vla-4
AU2001268701A1 (en) Methods of enhancing adhesion
AU2001288086A1 (en) Vulcanizable adhesive composition
AU2623800A (en) Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by vla-4
AU4810600A (en) Method of inhibiting leukocyte adhesion to fibrinogen
EP1369479A4 (en) "NEW CELL ADHESION MOLECULES SPECIFIC FOR ACTIVATED LEUKOCYTES"
AU2003251681A1 (en) Ghrelin binding nucleic acids
AU3348700A (en) Compounds which inhibit leukocyte adhesion mediated by vla-4
AU2003282162A1 (en) Novel adhesives comprising diacetals
AU2003265845A1 (en) METHODS FOR THE PREPARATION OF Beta-AMINO ACIDS
AU2003280382A1 (en) Enzymatic polymerisation of miniemulsions
AU2001249477A1 (en) Lactams as inhibitors of a-beta protein production