[go: up one dir, main page]

AU2001275340A1 - Integrated active flux microfluidic devices and methods - Google Patents

Integrated active flux microfluidic devices and methods

Info

Publication number
AU2001275340A1
AU2001275340A1 AU2001275340A AU7534001A AU2001275340A1 AU 2001275340 A1 AU2001275340 A1 AU 2001275340A1 AU 2001275340 A AU2001275340 A AU 2001275340A AU 7534001 A AU7534001 A AU 7534001A AU 2001275340 A1 AU2001275340 A1 AU 2001275340A1
Authority
AU
Australia
Prior art keywords
methods
microfluidic devices
integrated active
active flux
flux microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001275340A
Inventor
Hou-Pu Chou
Stephen R. Quake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
California Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology filed Critical California Institute of Technology
Publication of AU2001275340A1 publication Critical patent/AU2001275340A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3022—Micromixers the materials to be mixed flowing in the form of droplets the components being formed by independent droplets which are alternated, the mixing of the components being achieved by diffusion between droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3039—Micromixers with mixing achieved by diffusion between layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71755—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding components in a pulsating or intermittent manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
    • B01F35/717611—Peristaltic pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0324—With control of flow by a condition or characteristic of a fluid
    • Y10T137/0329—Mixing of plural fluids of diverse characteristics or conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2202—By movable element
    • Y10T137/2218—Means [e.g., valve] in control input
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
AU2001275340A 2000-06-05 2001-06-05 Integrated active flux microfluidic devices and methods Abandoned AU2001275340A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US20924300P 2000-06-05 2000-06-05
US60/209,243 2000-06-05
US21130900P 2000-06-13 2000-06-13
US60/211,309 2000-06-13
US24936000P 2000-11-16 2000-11-16
US60/249,360 2000-11-16
US09/724,548 2000-11-28
US09/724,548 US7351376B1 (en) 2000-06-05 2000-11-28 Integrated active flux microfluidic devices and methods
PCT/US2001/018400 WO2001094635A2 (en) 2000-06-05 2001-06-05 Integrated active flux microfluidic devices and methods

Publications (1)

Publication Number Publication Date
AU2001275340A1 true AU2001275340A1 (en) 2001-12-17

Family

ID=27498756

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001275340A Abandoned AU2001275340A1 (en) 2000-06-05 2001-06-05 Integrated active flux microfluidic devices and methods

Country Status (5)

Country Link
US (8) US7351376B1 (en)
EP (1) EP1290226A2 (en)
JP (1) JP2003536058A (en)
AU (1) AU2001275340A1 (en)
WO (1) WO2001094635A2 (en)

Families Citing this family (588)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7775368B2 (en) * 1995-04-03 2010-08-17 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
US8142708B2 (en) * 1995-04-03 2012-03-27 Wisconsin Alumni Research Foundation Micro fluidic system for single molecule imaging
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
JP4323571B2 (en) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド Optical device
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US8052792B2 (en) * 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US20080277007A1 (en) * 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
EP1065378B1 (en) 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
US7306672B2 (en) * 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AU2001249071B2 (en) * 2000-02-23 2005-09-08 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
WO2001067369A2 (en) * 2000-03-03 2001-09-13 California Institute Of Technology Combinatorial array for nucleic acid analysis
US7867763B2 (en) * 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002000343A2 (en) * 2000-06-27 2002-01-03 Fluidigm Corporation A microfluidic design automation method and system
DE10036174B4 (en) * 2000-07-25 2006-12-07 Axaron Bioscience Ag Method and apparatus for analyzing chemical or biological samples
US7998746B2 (en) * 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
EP1322936A2 (en) * 2000-10-03 2003-07-02 California Institute Of Technology Microfluidic devices and methods of use
US7678547B2 (en) * 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM USING A MICROFLUIDIC DEVICE, FOR ANALYSIS DEVICES
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
EP1345698A4 (en) * 2000-11-16 2006-05-17 Fluidigm Corp MICROFLUIDIC DEVICES FOR THE INTRODUCTION AND RELEASE OF LIQUIDS FROM MICROFLUIDIC SYSTEMS
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002043574A2 (en) 2000-11-29 2002-06-06 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6575188B2 (en) * 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US6752922B2 (en) * 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
ATE500051T1 (en) 2001-04-06 2011-03-15 Fluidigm Corp POLYMER SURFACE MODIFICATION
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US6981522B2 (en) * 2001-06-07 2006-01-03 Nanostream, Inc. Microfluidic devices with distributing inputs
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US20050149304A1 (en) * 2001-06-27 2005-07-07 Fluidigm Corporation Object oriented microfluidic design method and system
US7128876B2 (en) * 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
KR100421359B1 (en) * 2001-07-24 2004-03-06 엘지전자 주식회사 Method for delivering fluid in elastic substrate and device for it
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
WO2003031066A1 (en) 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
DE10150549A1 (en) * 2001-10-12 2003-04-17 Roche Diagnostics Gmbh Separation module, useful for the separation of corpuscles from blood, comprises two channels from a junction with a faster flow in one channel taking most of the particles, and a slower flow with few particles through the other channel
US8053249B2 (en) 2001-10-19 2011-11-08 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US7189580B2 (en) * 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
US7691244B2 (en) 2001-12-18 2010-04-06 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
AU2002364177A1 (en) * 2001-12-18 2003-06-30 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
AU2002363895A1 (en) * 2001-12-31 2003-07-15 Institut Fur Physikalische Hochtechnologie E.V. Cell sorting system for the size-based sorting or separation of cells suspended in a flowing fluid
JP3740528B2 (en) * 2002-02-05 2006-02-01 独立行政法人産業技術総合研究所 Fine particle manufacturing method
US6827811B2 (en) * 2002-02-07 2004-12-07 Lynntech, Inc. Method for vacuum pressing electrochemical cell components
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20030198962A1 (en) * 2002-04-18 2003-10-23 Yung-Chiang Chung Method and apparatus for nucleic acid hybridization
US7189581B2 (en) * 2002-04-30 2007-03-13 Wisconsin Alumni Research Foundation Method of obtaining a sample concentration of a solution in a microfluidic device
US7781159B2 (en) * 2002-05-09 2010-08-24 Nanologix, Inc. Micromethod and device for rapid detection, enumeration and identification of entities
US8361783B2 (en) * 2002-05-09 2013-01-29 Nanologix, Inc. Micromethod and device for the rapid detection, enumeration and identification of microorganisms
US8663909B2 (en) * 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
EP1514322A2 (en) * 2002-05-31 2005-03-16 Lynntech, Inc. Electrochemical cell and bipolar assembly for an electrochemical cell
DE10224567B4 (en) * 2002-06-03 2014-10-23 Boehringer Ingelheim Vetmedica Gmbh Sensor arrangement and method for operating a sensor arrangement
AU2003240295A1 (en) 2002-06-20 2004-01-06 Vision Biosystems Limited Biological reaction apparatus with draining mechanism
AU2003901871A0 (en) 2003-03-31 2003-05-08 Vision Biosystems Limited A method and apparatus for fluid dispensation, preparation and dilation
AU2003277853A1 (en) 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
JP2006507921A (en) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Method and apparatus for fluid dispersion
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
WO2004011365A2 (en) * 2002-07-26 2004-02-05 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7041258B2 (en) * 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US20040018115A1 (en) * 2002-07-29 2004-01-29 Nanostream, Inc. Fault tolerant detection regions in microfluidic systems
AU2003278700A1 (en) * 2002-07-31 2004-02-16 Arryx, Inc. System and method of sorting materials using holographic laser steering
US7699767B2 (en) * 2002-07-31 2010-04-20 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US8211629B2 (en) 2002-08-01 2012-07-03 Xy, Llc Low pressure sperm cell separation system
CA2534394C (en) 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US7743928B2 (en) * 2002-09-07 2010-06-29 Timothy Crowley Integrated apparatus and methods for treating liquids
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
JP2006501056A (en) * 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー Micro fluid large scale integration
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
JP5695287B2 (en) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー Nucleic acid analysis of microfluids
WO2004035212A1 (en) * 2002-10-18 2004-04-29 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
KR101216828B1 (en) 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 Methods and apparatus for pathogen detection and analysis
US7419638B2 (en) * 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US20080199685A1 (en) * 2003-02-10 2008-08-21 Michael Jeremiah Bortner Spray self assembly
GB2398751A (en) * 2003-02-28 2004-09-01 Univ Surrey A dielectrophoretic separation device
CN100439515C (en) * 2003-03-03 2008-12-03 清华大学 A nucleic acid analysis lab-on-a-chip system and its application
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US7041481B2 (en) * 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
DK2308419T3 (en) 2003-03-28 2016-06-06 Inguran Llc Procedure for assessing the staining conditions of animal sperm to be sorted.
EP1613737A4 (en) * 2003-03-28 2008-12-03 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
WO2004091763A2 (en) 2003-04-10 2004-10-28 President And Fellows Of Harvard College Formation and control of fluidic species
WO2004094020A2 (en) * 2003-04-17 2004-11-04 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
DE10320871B3 (en) * 2003-05-09 2004-09-16 Evotec Technologies Gmbh Sample distribution, for a cell sorter, comprises a fixed feed tube in a guide to deposit separate PCR samples at a moving micro-titration plate or sample strip without interfering with cell sorting
EP1625203B1 (en) 2003-05-15 2015-04-08 Xy, Llc Efficient haploid cell sorting for flow cytometer systems
CN1280428C (en) * 2003-05-19 2006-10-18 清华大学 Biochip system based on minute particle and its application
US7695683B2 (en) 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
EP1637889A1 (en) * 2003-06-19 2006-03-22 Arkray, Inc. Analyzer instrument with liquid storage portion
US7524623B2 (en) 2003-07-28 2009-04-28 Nanologix, Inc. Method and device for rapid detection of microorganisms by changing the shape of micro-colonies
US20050026135A1 (en) * 2003-07-28 2005-02-03 Sergey Gazenko Method for rapid detection of microorganisms by changing the shape of micro colonies
CA2532530A1 (en) * 2003-07-28 2005-02-10 Fluidigm Corporation Image processing method and system for microfluidic devices
JP4996248B2 (en) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド Processing of particle-containing samples
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7298478B2 (en) 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
EP2662136A3 (en) * 2003-08-27 2013-12-25 President and Fellows of Harvard College Method for handling and mixing droplets
AU2004317007A1 (en) 2003-09-03 2005-09-15 Life Patch International, Inc. Personal diagnostic devices and related methods
US7133132B2 (en) * 2003-09-19 2006-11-07 The Regents Of The University Of California Light-force sensor and method for measuring axial optical-trap forces from changes in light momentum along an optic axis
US7800750B2 (en) * 2003-09-19 2010-09-21 The Regents Of The University Of California Optical trap utilizing a reflecting mirror for alignment
JP4586021B2 (en) 2003-09-23 2010-11-24 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル Photocurable perfluoropolyethers for use as novel materials in microfluidic devices
DE20317944U1 (en) * 2003-11-18 2004-03-11 Heiser, Volker, Dr. Sample carrier for molecules
EP1541991A1 (en) * 2003-12-12 2005-06-15 STMicroelectronics S.r.l. Integrated semiconductor chemical microreactor for real-time monitoring of biological reactions
JP4711326B2 (en) * 2003-12-22 2011-06-29 キヤノン株式会社 Preparation method of calibration sample and calibration curve
KR100703889B1 (en) * 2003-12-29 2007-04-05 전자부품연구원 Device for solution component analysis and its manufacturing method
US20050147980A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
WO2005072353A2 (en) * 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
WO2007021762A2 (en) 2005-08-09 2007-02-22 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
SG150506A1 (en) * 2004-02-13 2009-03-30 Univ North Carolina State Functional materials and novel methods for the fabrication of microfluidic devices
US8765454B2 (en) * 2004-02-18 2014-07-01 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
WO2005082535A1 (en) * 2004-02-27 2005-09-09 University Of Limerick Buoyancy-driven microfluidics
US8372600B2 (en) * 2004-03-05 2013-02-12 The Research Foundation Of State University Of New York Method and apparatus for measuring changes in cell volume
JP2007527540A (en) * 2004-03-05 2007-09-27 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク Method and apparatus for measuring cell volume change
WO2005089253A2 (en) * 2004-03-12 2005-09-29 The Regents Of The University Of California Methods and apparatus for integrated cell handling and measurements
JP4643921B2 (en) * 2004-03-26 2011-03-02 独立行政法人科学技術振興機構 Method for detecting passage of fluid in a flow path and method for controlling fluid flow
WO2005095590A2 (en) 2004-03-29 2005-10-13 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20050249641A1 (en) * 2004-04-08 2005-11-10 Boehringer Ingelheim Microparts Gmbh Microstructured platform and method for manipulating a liquid
EP1742730A1 (en) * 2004-04-27 2007-01-17 Agilent Technologies, Inc. Microfluidic connection
JP5502275B2 (en) * 2004-05-02 2014-05-28 フルイディグム コーポレイション Thermal reaction device and method of using the thermal reaction device
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA2994321C (en) 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
US8642353B2 (en) * 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
JP5057968B2 (en) * 2004-05-10 2012-10-24 ザ エアロスペース コーポレーション Microfluidic device having separable operating module and fluid holding module
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
GB0410579D0 (en) * 2004-05-12 2004-06-16 Univ St Andrews Optoelectronic tweezers
US20060024751A1 (en) * 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
US7758814B2 (en) * 2004-06-05 2010-07-20 Freeslate, Inc. Microfluidic fluid distribution manifold for use with multi-channel reactor systems
US7307802B2 (en) * 2004-06-07 2007-12-11 Fluidigm Corporation Optical lens system and method for microfluidic devices
US20050272144A1 (en) * 2004-06-08 2005-12-08 Konica Minolta Medical & Graphic, Inc. Micro-reactor for improving efficiency of liquid mixing and reaction
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
JP2006006166A (en) * 2004-06-24 2006-01-12 Univ Of Tokyo Cell separation device and cell separation method
US7686040B2 (en) * 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7575681B2 (en) * 2004-07-06 2009-08-18 Schlumberger Technology Corporation Microfluidic separator
US8262909B2 (en) * 2004-07-06 2012-09-11 Schlumberger Technology Corporation Methods and devices for minimizing membrane fouling for microfluidic separators
AR049732A1 (en) 2004-07-22 2006-08-30 Monsanto Co PROCESS TO ENRICH A Sperm Cell Population
US7884052B2 (en) 2004-09-03 2011-02-08 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
EP1789792A2 (en) * 2004-09-11 2007-05-30 Receptors LLC Combinatorial artificial receptors including peptide building blocks
EP1794581A2 (en) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Microfluidic devices
AU2005289352B2 (en) * 2004-09-28 2007-02-22 Cleveland Biosensors Pty Ltd Microfluidic device
WO2006034525A1 (en) * 2004-09-28 2006-04-06 Cleveland Biosensors Pty Ltd Microfluidic device
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
WO2006039566A2 (en) * 2004-09-30 2006-04-13 Intelliseek, Inc. Topical sentiments in electronically stored communications
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102004049730B4 (en) * 2004-10-11 2007-05-03 Technische Universität Darmstadt Microcapillary reactor and method for controlled mixing of non-homogeneously miscible fluids using this microcapillary reactor
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US7674994B1 (en) * 2004-10-21 2010-03-09 Valerio Thomas A Method and apparatus for sorting metal
US8232095B2 (en) * 2004-11-18 2012-07-31 The Regents Of The University Of California Apparatus and methods for manipulation and optimization of biological systems
CN101099082B (en) 2004-12-03 2013-03-27 塞通诺米/St有限责任公司 Integral cassettes for particle handling
JP2008522795A (en) * 2004-12-03 2008-07-03 カリフォルニア インスティチュート オブ テクノロジー Microfluidic device with chemical reaction circuit
US20080264863A1 (en) * 2004-12-03 2008-10-30 California Institute Of Technology Microfluidic Sieve Valves
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
PL1859330T3 (en) 2005-01-28 2013-01-31 Univ Duke Apparatuses and methods for manipulating droplets on a printed circuit board
US20060170905A1 (en) * 2005-02-02 2006-08-03 Tsai George P Common carrier for loading capillary vessels
US20060170444A1 (en) * 2005-02-02 2006-08-03 Wu Zong M Novel fluorescent and photoemission apparatus and method for submicron IC failure analysis
US20060171855A1 (en) * 2005-02-03 2006-08-03 Hongfeng Yin Devices,systems and methods for multi-dimensional separation
EP1861194A2 (en) 2005-03-04 2007-12-05 The President and Fellows of Harvard College Method and apparatus for forming multiple emulsions
EP1864185A4 (en) * 2005-03-08 2011-03-23 Forskarpatent I Linkoeping Ab Micro and nano structures in an elastomeric material
EP1882189A2 (en) 2005-04-20 2008-01-30 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
US20070042427A1 (en) * 2005-05-03 2007-02-22 Micronics, Inc. Microfluidic laminar flow detection strip
US8206974B2 (en) * 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
CA2610875A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
TWI253435B (en) * 2005-06-13 2006-04-21 Univ Chung Yuan Christian Loop micro fluid system
US9158855B2 (en) 2005-06-16 2015-10-13 Buzzmetrics, Ltd Extracting structured data from weblogs
WO2007030240A2 (en) * 2005-08-01 2007-03-15 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
US20090139576A1 (en) * 2005-08-11 2009-06-04 Eksigent Technologies, Llc Microfluidic systems, devices and methods for reducing noise generated by mechanical instabilities
WO2007024485A2 (en) * 2005-08-11 2007-03-01 Eksigent Technologies, Llc Microfluidic reduction of diffusion and complience effect in a fluid mixing region
WO2007021812A1 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic apparatus and method for sample preparation and analysis
US20070054293A1 (en) * 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
WO2007038259A2 (en) 2005-09-23 2007-04-05 Massachusetts Institute Of Technology Optical trapping with a semiconductor
CN101317086B (en) 2005-10-04 2013-08-14 海德威技术公司 Microfluidic detection of analytes
WO2007043619A1 (en) * 2005-10-13 2007-04-19 Nissui Pharmaceutical Co., Ltd. Testing device
US7659486B2 (en) * 2005-10-20 2010-02-09 Valerio Thomas A Method and apparatus for sorting contaminated glass
AU2006344046A1 (en) * 2005-10-24 2007-11-29 Valerio, Thomas A Dissimilar materials sorting process, system and apparatus
DK1957794T3 (en) * 2005-11-23 2014-08-11 Eksigent Technologies Llc Electrokinetic pump designs and drug delivery systems
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US8173077B2 (en) * 2005-12-16 2012-05-08 The Curators Of The University Of Missouri Reusable PCR amplification system and method
CN101341405A (en) * 2005-12-21 2009-01-07 皇家飞利浦电子股份有限公司 A sensor for biomolecules and a method for preparing and using the same
EP3913375A1 (en) * 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc Microfluidic devices
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
ES2692380T3 (en) 2006-03-24 2018-12-03 Handylab, Inc. Method to perform PCR with a cartridge with several tracks
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US20100028614A1 (en) * 2006-03-29 2010-02-04 Anne Shim Method of forming nanoscale features using soft lithography
JP4664846B2 (en) * 2006-03-29 2011-04-06 株式会社東芝 Nucleic acid detection device
DE102006016324A1 (en) * 2006-04-06 2007-10-25 Wacker Chemie Ag Apparatus and method for flexibly classifying polycrystalline silicon fragments
JP4167697B2 (en) * 2006-04-13 2008-10-15 株式会社東芝 Nucleic acid detection device
KR100773552B1 (en) * 2006-04-28 2007-11-07 삼성전자주식회사 Microfluidic reaction vessel, preparation method thereof, and microfluidic reaction method using the same
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2021113A2 (en) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Microfluidic devices
JP2009539625A (en) * 2006-06-02 2009-11-19 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Soft MEMS device
JP4292279B2 (en) * 2006-07-18 2009-07-08 ファルマ・アクセス株式会社 Crystal production tool
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US8656949B2 (en) * 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
US7787681B2 (en) * 2006-08-25 2010-08-31 The Trustees Of Columbia University In The City Of New York Systems and methods for robotic transport
US20080176755A1 (en) 2006-08-25 2008-07-24 The Trustees Of Columbia University In The City Of New York, Office Of The General Counsel Systems and methods for biodosimetry with biochip using gene expression signatures
US20090061508A1 (en) * 2007-08-27 2009-03-05 Biomimetics Technologies Inc Laminar flow reactor
US9057044B2 (en) 2006-08-30 2015-06-16 Meir Israelowitz Laminar flow reactor
US8055034B2 (en) * 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US8050516B2 (en) * 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
WO2008043041A1 (en) 2006-10-04 2008-04-10 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
WO2008147428A1 (en) * 2006-10-05 2008-12-04 Nanopoint, Inc. Systems and methods for active microfluidic cell handling
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
US9097671B2 (en) * 2006-11-22 2015-08-04 Clondiag Gmbh Assays
US9114398B2 (en) 2006-11-29 2015-08-25 Canon U.S. Life Sciences, Inc. Device and method for digital multiplex PCR assays
WO2008067552A2 (en) * 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
EP1931158B1 (en) * 2006-12-08 2013-04-10 Samsung Electronics Co., Ltd. Apparatus and method for selecting frame structure in multihop relay broadband wireless access communication system
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US20080160638A1 (en) * 2006-12-27 2008-07-03 David Lederman Functionalized Microcantilever Sensor and Associated Method For Detection of Targeted Analytes
WO2008083323A1 (en) * 2006-12-29 2008-07-10 Invitrogen Corporation Detection apparatus
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
CA2674503A1 (en) * 2007-01-05 2008-07-17 Thomas A. Valerio System and method for sorting dissimilar materials
US7668526B2 (en) * 2007-01-16 2010-02-23 Harris Corporation Frequency mixer using current feedback amplifiers
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
US10001496B2 (en) * 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US20080181816A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Systems for allergen detection
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
US20090050569A1 (en) * 2007-01-29 2009-02-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
CN101715483A (en) 2007-02-05 2010-05-26 微芯片生物工艺学股份有限公司 microfluidic and nanofluidic devices, systems, and applications
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US20080254530A1 (en) * 2007-02-27 2008-10-16 Gettysburg College Isolation and characterization of a single mitochondrion
CA2680558A1 (en) * 2007-03-13 2008-09-18 The Governors Of The University Of Alberta Clinical sample preparation on a microfluidic platform
US20100227338A1 (en) * 2007-03-22 2010-09-09 Nanologix, Inc. Method and Apparatus for Rapid Detection and Identification of Live Microorganisms Immobilized On Permeable Membrane by Antibodies
US9068216B2 (en) 2007-03-22 2015-06-30 Bret T. Barnhizer Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP2010523121A (en) * 2007-04-05 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー System for electrophoretic stretching of biomolecules using microscale T-contacts
US8186913B2 (en) 2007-04-16 2012-05-29 The General Hospital Corporation Systems and methods for particle focusing in microchannels
EP2148772A1 (en) * 2007-04-18 2010-02-03 Thomas A. Valerio Method and system for sorting and processing recycled materals
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN101743063B (en) * 2007-05-03 2012-12-12 科隆迪亚戈有限公司 Analytical method
US8597729B2 (en) 2007-06-22 2013-12-03 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
US8921121B2 (en) * 2007-06-29 2014-12-30 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for chemiluminescence-based microfluidic cell counting
US8431090B2 (en) * 2007-06-29 2013-04-30 The Trustees Of Columbia University In The City Of New York Microfluidic device for counting biological particles
JP5507454B2 (en) * 2007-07-09 2014-05-28 フィオ コーポレイション System and method for improved fluorescence detection of target molecules in a test sample
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
ES2648798T3 (en) 2007-07-13 2018-01-08 Handylab, Inc. Polynucleotide capture materials and methods of use thereof
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) * 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
WO2009012585A1 (en) * 2007-07-23 2009-01-29 Fio Corporation A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
JP2009031126A (en) * 2007-07-27 2009-02-12 Kazusa Dna Kenkyusho A chip for a microbead array using a microchannel forming body, a microbead array, and a method for detecting a test substance using the chip.
WO2009021233A2 (en) * 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
US8211709B2 (en) * 2007-08-22 2012-07-03 Wisconsin Alumni Research Foundation Method for controlling communication between multiple access ports in a microfluidic device
CN101821619B (en) 2007-09-07 2015-02-11 弗卢丁公司 Copy number variation determination, methods and systems
US8551763B2 (en) * 2007-10-12 2013-10-08 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
US20100297747A1 (en) * 2007-10-25 2010-11-25 Manalis Scott R System and method for monitoring cell growth
US8251672B2 (en) 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
CA2623793C (en) * 2008-03-03 2010-11-23 Schlumberger Canada Limited Microfluidic apparatus and method for measuring thermo-physical properties of a reservoir fluid
US8340913B2 (en) * 2008-03-03 2012-12-25 Schlumberger Technology Corporation Phase behavior analysis using a microfluidic platform
CN104459148B (en) 2008-03-14 2017-06-16 科隆迪亚戈有限公司 Analysis
EP2259072A4 (en) * 2008-03-24 2016-03-30 Nec Corp Flow passage control mechanism for microchip
EP2280905B1 (en) 2008-04-11 2016-07-06 Fluidigm Corporation Multilevel microfluidic systems and methods
US8298392B2 (en) * 2008-04-21 2012-10-30 University Of Louisville Research Foundation, Inc. Microfluidic devices and methods of using same
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
CN101587029B (en) * 2008-05-21 2013-10-23 同方威视技术股份有限公司 Sample processing system and method for trace detector
US9068181B2 (en) 2008-05-23 2015-06-30 The General Hospital Corporation Microfluidic droplet encapsulation
US8389294B2 (en) * 2008-06-09 2013-03-05 Wisconsin Alumni Research Foundation Microfluidic device and method for coupling discrete microchannels and for co-culture
MX2010013578A (en) 2008-06-11 2011-03-21 a valerio Thomas Method and system for recovering metal from processed recycled materials.
US8062612B2 (en) 2008-06-20 2011-11-22 Silverbrook Research Pty Ltd MEMS integrated circuit comprising microfluidic diaphragm valve
US20090315126A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidic System Comprising Thermal Bend Actuated Valve
US8075855B2 (en) * 2008-06-20 2011-12-13 Silverbrook Research Pty Ltd MEMS integrated circuit comprising peristaltic microfluidic pump
US20090314367A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidics System Comprising CMOS-Controllable Microfluidic Devices
US8080220B2 (en) * 2008-06-20 2011-12-20 Silverbrook Research Pty Ltd Thermal bend actuated microfluidic peristaltic pump
US20090317302A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising MEMS Integrated Circuit
US8092761B2 (en) 2008-06-20 2012-01-10 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic diaphragm valve
US20090314368A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising Pinch Valve and On-Chip MEMS Pump
US20090317301A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidics System Comprising MEMS-Actuated Microfluidic Devices
US7981386B2 (en) * 2008-06-20 2011-07-19 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic valve
CN102132330B (en) 2008-06-25 2015-07-22 Fio公司 Bio-Threat Alert System
US8122901B2 (en) 2008-06-30 2012-02-28 Canon U.S. Life Sciences, Inc. System and method for microfluidic flow control
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
AU2009274103A1 (en) * 2008-07-21 2010-01-28 Mtd America Ltd (Llc) Method and system for removing polychlorinated biphenyls from plastics
US9579830B2 (en) 2008-07-25 2017-02-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
WO2010017210A1 (en) 2008-08-07 2010-02-11 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
EP2329045A4 (en) * 2008-08-15 2012-09-19 Univ Cornell DEVICE FOR THE FAST IDENTIFICATION OF NUCLEIC ACIDS FOR BINDING TO SPECIFIC CHEMICAL TARGET MOLECULES
US9459200B2 (en) 2008-08-29 2016-10-04 Fio Corporation Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US10512910B2 (en) * 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9089844B2 (en) 2010-11-01 2015-07-28 Bio-Rad Laboratories, Inc. System for forming emulsions
CN102405402A (en) 2008-09-23 2012-04-04 阔达生命有限公司 Droplet-based assay system
WO2011120006A1 (en) 2010-03-25 2011-09-29 Auantalife, Inc. A Delaware Corporation Detection system for droplet-based assays
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9598725B2 (en) * 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US20100075863A1 (en) * 2008-09-25 2010-03-25 Northrop Grumman Systems Corporation Rotary array module for multiplexing spot-based optical readouts
US20100081577A1 (en) * 2008-09-30 2010-04-01 Symyx Technologies, Inc. Reactor systems and methods
WO2010040103A1 (en) 2008-10-03 2010-04-08 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
WO2010062441A1 (en) * 2008-10-31 2010-06-03 Massachusetts Institute Of Technology Fast curable liquid resin procedure for the manufacture of micro/nano featured parts
EP2202522A1 (en) * 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
CN104374932A (en) 2009-01-13 2015-02-25 Fio公司 A handheld diagnostic test device used with an electronic device and a test cartridge in a rapid diagnostic test
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8828715B2 (en) * 2009-03-06 2014-09-09 Cfd Research Corporation Particle adhesion assay for microfluidic bifurcations
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9211539B2 (en) * 2009-04-02 2015-12-15 Purdue Research Foundation Variable volume mixing and automatic fluid management for programmable microfluids
EP2414547B1 (en) 2009-04-02 2014-03-12 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
EP3299812B1 (en) 2009-04-13 2020-03-11 University of Washington Rare particle detection method and apparatus
CN102802797A (en) * 2009-04-21 2012-11-28 艾德万德克斯公司 Multiplex analysis of cells, particles, and other analytes
US8627960B2 (en) * 2009-04-28 2014-01-14 Mtd America Ltd (Llc) Apparatus and method for separating materials using air
CN102422164B (en) * 2009-05-15 2015-12-16 柯尼卡美能达株式会社 Microchip
CN102459565A (en) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 Fluidic devices with diaphragm valves
WO2010141131A1 (en) 2009-06-04 2010-12-09 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
BRPI1010169A2 (en) 2009-06-05 2016-03-29 Integenx Inc system that fits within a housing of no more than 10 ft3, cartridge, computer readable article, method, system configured to perform a method, optical system, instrument and device.
JP5841937B2 (en) 2009-06-26 2016-01-13 プレジデント アンド フェローズ オブ ハーバード カレッジ Fluid injection
US20110001963A1 (en) * 2009-07-02 2011-01-06 Durack Gary P System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system
TW201105971A (en) * 2009-07-06 2011-02-16 Sony Corp Microfluidic device having onboard tissue or cell sample handling capability
CN102472701A (en) * 2009-07-06 2012-05-23 索尼公司 Microfluidic device
CN102472702B (en) * 2009-07-07 2014-05-21 索尼公司 A method of detecting particles in a sample
US8735088B2 (en) * 2009-07-07 2014-05-27 Sony Corporation Method to analyze a sample fluid in a microfluidic cytometry system
WO2011005754A1 (en) * 2009-07-08 2011-01-13 Sony Corporation Microfluidic device having a flow channel within a gain medium
AU2010276224A1 (en) * 2009-07-21 2012-02-23 Thomas A. Velerio Method and system for separating and recovering like-type materials from an electronic waste system
US8551787B2 (en) * 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
US8757523B2 (en) 2009-07-31 2014-06-24 Thomas Valerio Method and system for separating and recovering wire and other metal from processed recycled materials
US8360347B2 (en) * 2009-07-31 2013-01-29 Thomas A. Valerio Method and system for separating and recovering wire and other metal from processed recycled materials
US9364831B2 (en) 2009-08-08 2016-06-14 The Regents Of The University Of California Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
CA3021714C (en) 2009-09-02 2021-03-09 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
EP2473263B1 (en) 2009-09-02 2022-11-02 President and Fellows of Harvard College Multiple emulsions created using jetting and other techniques
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8707734B2 (en) * 2009-10-19 2014-04-29 The Regents Of The University Of Michigan Method of embedding material in a glass substrate
KR101532314B1 (en) * 2009-10-27 2015-06-29 삼성전자주식회사 Quality control method and quality control device for microfluidic device
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9229001B2 (en) 2009-11-23 2016-01-05 Cyvek, Inc. Method and apparatus for performing assays
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011066588A1 (en) 2009-11-30 2011-06-03 Fluidigm Corporation Microfluidic device regeneration
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
JP2013527022A (en) * 2010-01-24 2013-06-27 インスチチュート・ケミィ・フィジズネジ・ポルスキージ・アカデミィ・ナウク System and method for automatic formation and manipulation of liquid mixtures.
CN102740976B (en) 2010-01-29 2016-04-20 精密公司 Sample-Response Microfluidic Cartridges
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP2556170A4 (en) 2010-03-25 2014-01-01 Quantalife Inc Droplet transport system for detection
ITTO20100068U1 (en) * 2010-04-20 2011-10-21 Eltek Spa MICROFLUID AND / OR EQUIPMENT DEVICES FOR MICROFLUID DEVICES
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
WO2011151250A1 (en) * 2010-05-31 2011-12-08 Boehringer Ingelheim Microparts Gmbh Method and device for optical examination
US20110312759A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Genetic analysis loc with reagent reservoir
CN105342552B (en) * 2010-06-30 2018-10-16 安派科生物医学科技有限公司 disease detection instrument
EP2606242A4 (en) 2010-08-20 2016-07-20 Integenx Inc MICROFLUIDIC DEVICES HAVING MECHANICALLY SEALED DIAPHRAGM VALVES
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
KR101251223B1 (en) * 2010-08-25 2013-04-08 서울대학교산학협력단 A Method for Manufacturing liquid Droplet Microarrays, Microarrays Prepared by Using the Same, a Device for Delivering Materials and a Method for Delivering Materials by Using a Device for Delivering Materials Comprising the Same
US20160084805A1 (en) * 2010-09-23 2016-03-24 Battelle Memorial Institute System and method of preconcentrating analytes in a microfluidic device
US20150041396A1 (en) * 2010-09-23 2015-02-12 Battelle Memorial Institute System and method of preconcentrating analytes in a microfluidic device
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
US10221412B2 (en) 2010-10-05 2019-03-05 Pcl, Inc. Multiplex microfluidic device for selecting nucleic acid aptamers, and high throughput selection method for nucleic acid aptamers using same
WO2012051529A1 (en) 2010-10-15 2012-04-19 Lockheed Martin Corporation Micro fluidic optic design
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
US8815179B2 (en) * 2010-12-03 2014-08-26 Alfa Wassermann, Inc. Automated aseptic liquid collection workstations and collection devices therefore
CN103328089B (en) * 2010-12-21 2016-09-07 哈佛学院院长等 spray drying technology
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
US9176504B2 (en) 2011-02-11 2015-11-03 The Regents Of The University Of California High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
US9488613B2 (en) 2011-03-02 2016-11-08 Massachusetts Institute Of Technology Systems, devices and methods for multiplexed diagnostics
WO2012119128A1 (en) * 2011-03-02 2012-09-07 Massachusetts Institute Of Technology Multiplexed diagnostic systems
CN103534360A (en) 2011-03-18 2014-01-22 伯乐生命医学产品有限公司 Multiplexed digital assays with combinatorial use of signals
CN103649759B (en) 2011-03-22 2016-08-31 西维克公司 Microfluidic device and method of manufacture and use
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
CA2831223C (en) * 2011-03-24 2019-04-02 Anpac Bio-Medical Science (Lishui) Co., Ltd. Micro-devices for disease detection
CA3082652A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
AU2012249759A1 (en) 2011-04-25 2013-11-07 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
US20120275929A1 (en) * 2011-04-27 2012-11-01 Aptina Imaging Corporation Ferrofluid control and sample collection for microfluidic application
CN107012078B (en) * 2011-05-05 2020-11-06 安派科生物医学科技有限公司 Tumor cell detector
CA2834708A1 (en) 2011-05-05 2012-11-08 Eksigent Technologies, Llc Gel coupling for electrokinetic delivery systems
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
WO2012154876A1 (en) 2011-05-09 2012-11-15 Fluidigm Corporation Probe based nucleic acid detection
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
KR101240210B1 (en) * 2011-06-03 2013-03-06 인제대학교 산학협력단 Microfluidic platform for parallel systematic evolution of ligands by exponential enrichment
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2737089B1 (en) 2011-07-29 2017-09-06 Bio-rad Laboratories, Inc. Library characterization by digital assay
US20130083311A1 (en) * 2011-09-29 2013-04-04 Melissa Li Microfluidic system for optical measurement of platelet aggregation
CN103959070B (en) 2011-09-30 2017-05-10 贝克顿·迪金森公司 Combination reagent strips
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
KR101294225B1 (en) * 2011-09-30 2013-08-07 한국과학기술원 Method for controlling water droplet movement using microfluidic device
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CN104040238B (en) 2011-11-04 2017-06-27 汉迪拉布公司 Polynucleotides sample preparation apparatus
EP2786019B1 (en) 2011-11-16 2018-07-25 International Business Machines Corporation Microfluidic device with deformable valve
CA2856779C (en) 2011-11-22 2021-07-20 Stephen G. Haralampu Stopped-flow, m icro-flu i imc device and method for the charge-based separation of complex analyte mixtures
ES2978107T3 (en) 2012-02-03 2024-09-05 Becton Dickinson Co External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9304065B2 (en) 2012-02-29 2016-04-05 Fluidigm Corporation Methods, systems and devices for multiple single-cell capturing and processing using microfluidics
US9878137B2 (en) 2012-05-30 2018-01-30 The Regents Of The University Of California Bioactive agent delivery devices and methods of making and using the same
US9278353B2 (en) 2012-06-25 2016-03-08 The General Hospital Corporation Sorting particles using high gradient magnetic fields
US8723104B2 (en) * 2012-09-13 2014-05-13 City University Of Hong Kong Methods and means for manipulating particles
DE102012217487A1 (en) * 2012-09-26 2014-04-17 Agilent Technologies, Inc. - A Delaware Corporation - Fluid interface between fluid lines of different cross sections
US9259353B2 (en) * 2012-10-11 2016-02-16 Alcon Research, Ltd. Capillary action in flow-regulating systems
CN105008895B (en) 2012-10-15 2019-02-15 纳诺赛莱克特生物医药股份有限公司 System, apparatus and method for particle sorting
EP2934751B1 (en) 2012-12-21 2019-05-29 Micronics, Inc. Low elasticity films for microfluidic use
KR102102123B1 (en) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. Fluidic circuits and related manufacturing methods
EP2935559B1 (en) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluorescence detection system
WO2014165185A1 (en) 2013-03-12 2014-10-09 The Regents Of The University Of Michigan Microfluidic device for immunoblotting
US10071359B2 (en) 2013-03-15 2018-09-11 The Regents Of The University Of California High-speed on demand microfluidic droplet generation and manipulation
CN105164246B (en) 2013-03-15 2018-09-25 富鲁达公司 The method and apparatus that many cells for analytic definition combine
US20140323819A1 (en) * 2013-04-29 2014-10-30 Elwha LLC, a limited liability company of the State of Delaware Multi-parameter test units for initial indication of medical symptoms
EP2994750B1 (en) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CN105189750B (en) 2013-05-07 2020-07-28 珀金埃尔默健康科学有限公司 Method for preparing nucleic acid-containing samples using clay minerals and alkaline solutions
JP6484222B2 (en) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド Devices for nucleic acid preparation and analysis
CN105518464B (en) 2013-07-05 2019-12-03 华盛顿大学商业中心 Methods, compositions and systems for microfluidic analysis
US9785731B1 (en) * 2013-08-26 2017-10-10 DataInfoCom USA, Inc. Prescriptive reservoir asset management
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
WO2015050998A2 (en) 2013-10-01 2015-04-09 The Broad Institute, Inc. Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte
US10132739B2 (en) * 2013-10-01 2018-11-20 Owl biomedical, Inc. Particle manipulation system with out-of-plane channel and recovery algorithm
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
EP3058316B1 (en) 2013-10-18 2019-03-13 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
FR3013839B1 (en) * 2013-11-26 2016-07-29 Inst Nat Polytechnique Toulouse DEVICE FOR TREATING A SAMPLE OF AN ACTIVE BIOLOGICAL FLUID
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
KR20160123305A (en) * 2014-01-20 2016-10-25 핼시언 바이오메디컬, 인코퍼레이티드 Passive separation of whole blood
US9387451B2 (en) 2014-02-03 2016-07-12 International Business Machines Corporation Flow cell array and uses thereof
JP6607505B2 (en) 2014-03-07 2019-11-20 ナショナル リサーチ カウンシル オブ カナダ Centrifugal microfluidic chip controller
WO2015167990A1 (en) * 2014-04-29 2015-11-05 Battelle Memorial Institute Microfluidic sample injector absent electrokinetic injection
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US20170212076A1 (en) * 2014-07-30 2017-07-27 Dh Technologies Development Pte. Ltd. Devices and Methods for Processing Fluid Samples
US10166542B2 (en) 2014-09-17 2019-01-01 Arizona Board Of Regents On Behalf Of Arizona State University Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
US10331039B2 (en) 2014-10-02 2019-06-25 Asml Netherlands B.V. Rule-based deployment of assist features
CN107106983B (en) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 Systems and methods for sample preparation, processing and analysis
US9895694B2 (en) 2014-11-03 2018-02-20 The General Hospital Corporation Sorting particles in a microfluidic device
US11241687B2 (en) * 2014-11-26 2022-02-08 Imec Vzw Compact glass-based fluid analysis device and method to fabricate
WO2016145050A1 (en) 2015-03-10 2016-09-15 Carbon3D, Inc. Microfluidic devices having flexible features and methods of making the same
JP6678998B2 (en) * 2015-03-24 2020-04-15 国立大学法人 東京大学 Fluidic devices, systems and methods
WO2016153000A1 (en) * 2015-03-24 2016-09-29 国立大学法人東京大学 Fluid device, system and method
GB201509640D0 (en) * 2015-06-03 2015-07-15 Sphere Fluidics Ltd Systems and methods
WO2017004250A1 (en) 2015-06-29 2017-01-05 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
JP6882782B2 (en) 2015-08-04 2021-06-02 デューク ユニバーシティ Genetically encoded, essentially chaotic delivery stealth polymers and how to use them
WO2017027838A1 (en) 2015-08-13 2017-02-16 President And Fellows Of Harvard College Microfluidic devices and systems for cell culture and/or assay
US11071982B2 (en) * 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
JP6704920B2 (en) * 2015-10-14 2020-06-03 アルプスアルパイン株式会社 Flow path structure and measuring device for liquid to be measured
WO2017074815A1 (en) * 2015-10-26 2017-05-04 Idexx Laboratories, Inc. Hematology test slide
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
KR101840530B1 (en) * 2016-01-08 2018-05-04 고려대학교 산학협력단 Surface measurement sensing-based realtime nucleic acid amplification measuring apparatus
CN108139241B (en) 2016-01-22 2020-02-14 惠普发展公司，有限责任合伙企业 Fluid sensing with control of particle aggregation in the sensing region
US20170241961A1 (en) * 2016-02-22 2017-08-24 University Of Utah Research Foundation Micro Circulatory Gas Chromatography System and Method
SG11201808959QA (en) 2016-04-15 2018-11-29 Fluid Screen Inc Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
CA3027643C (en) * 2016-07-06 2021-01-19 Precision Nanosystems Inc Smart microfluidic mixing instrument and cartridges
US10500587B2 (en) 2016-07-20 2019-12-10 Boise State University Ferro-magnetic shape memory alloy microcavity fluid sensor
JP6821785B2 (en) 2016-07-22 2021-01-27 アルファ ワッサーマン インコーポレイテッドＡｌｆａ Ｗａｓｓｅｒｍａｎｎ，Ｉｎｃ． Fluid handling systems and methods for ultracentrifuges
WO2018032458A1 (en) * 2016-08-18 2018-02-22 Shenzhen Genorivision Technology Co. Ltd. An electrophoresis chip with an integrated optical sensor
WO2018051242A1 (en) 2016-09-14 2018-03-22 Ecole Polytechnique Federale De Lausanne (Epfl) Device for high throughput single-cell studies
JP2020500150A (en) 2016-09-23 2020-01-09 デューク ユニバーシティ Non-repetitive and non-structural polypeptides with lower critical solution temperature behavior
US11016053B2 (en) 2016-10-05 2021-05-25 Abbott Laboratories Devices and methods for sample analysis
CN106568696B (en) * 2016-11-14 2019-02-05 江苏大学 Crop fungal disease prevention and detection device and method based on microfluidic chip
CN106754241B (en) * 2016-11-27 2018-10-23 重庆科技学院 A kind of application method of the drug screening biochip with gas chamber
CN106350440B (en) * 2016-11-27 2018-06-26 重庆科技学院 A kind of drug screening biochip with gas chamber
JP2020500517A (en) 2016-11-28 2020-01-16 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ Systems and methods relating to continuous flow droplet reactions
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US20200376499A1 (en) * 2017-01-26 2020-12-03 Delee Corp. Dielectrophoresis Separation Object Sorting
US11982611B2 (en) 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
US10596567B2 (en) * 2017-03-27 2020-03-24 International Business Machines Corporation Microfluidic ratchets for displacing particles
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
US10969350B2 (en) 2017-05-22 2021-04-06 Arizona Board Of Regents On Behalf Of Arizona Stat Metal electrode based 3D printed device for tuning microfluidic droplet generation frequency and synchronizing phase for serial femtosecond crystallography
WO2018217793A1 (en) * 2017-05-22 2018-11-29 Arizona Board Of Regents On Behalf Of Arizona State University 3d printed microfluidic mixers and nozzles for crystallography
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
SG11202001914QA (en) 2017-09-11 2020-04-29 Evorion Biotechnologies Gmbh Systems, methods and hydrogels for cell culture and analysis
US11173487B2 (en) 2017-12-19 2021-11-16 Arizona Board Of Regents On Behalf Of Arizona State University Deterministic ratchet for sub-micrometer bioparticle separation
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
US10935149B2 (en) 2018-03-15 2021-03-02 University Of Washington Temperature-actuated valve, fluidic device, and related methods of use
WO2019195197A1 (en) 2018-04-02 2019-10-10 Dropworks, Inc. Systems and methods for serial flow emulsion processes
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
JP7410935B2 (en) 2018-05-24 2024-01-10 ザ リサーチ ファウンデーション フォー ザ ステイト ユニバーシティー オブ ニューヨーク capacitive sensor
FR3082440B1 (en) * 2018-06-14 2020-12-11 Paris Sciences Lettres Quartier Latin MATERIAL TRANSFER METHOD IN A MICROFLUIDIC OR MILLIFLUIDIC DEVICE
WO2020003538A1 (en) * 2018-06-29 2020-01-02 株式会社ニコン Fluid device, system, and mixing method
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
WO2020028806A1 (en) 2018-08-02 2020-02-06 Duke University Dual agonist fusion proteins
US11314375B2 (en) 2018-10-01 2022-04-26 Precigenome, LLC Multichannel pressure control system with user friendly interface
WO2020139936A1 (en) 2018-12-27 2020-07-02 The General Hospital Corporation Size-based particle separation and concentration using particle size amplification
JP2022522868A (en) 2019-03-13 2022-04-20 エヴォリオン ビーオテヒノロギース ゲーエムベーハー Methods and kits for determining biomolecules secreted by cells
EP3953044A4 (en) * 2019-04-08 2022-06-01 Technion Research & Development Foundation Limited Multiplexed array of nanoliter droplet array devices
US11624718B2 (en) 2019-05-14 2023-04-11 Arizona Board Of Regents On Behalf Of Arizona State University Single piece droplet generation and injection device for serial crystallography
US11318487B2 (en) 2019-05-14 2022-05-03 Arizona Board Of Regents On Behalf Of Arizona State University Co-flow injection for serial crystallography
WO2020241160A1 (en) * 2019-05-29 2020-12-03 パナソニックＩｐマネジメント株式会社 Detection method and detection device
CA3142449A1 (en) 2019-06-20 2020-12-24 President And Fellows Of Harvard College Isolating live cells after high-throughput, long-term, time-lapse microscopy
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
GR1010186B (en) * 2019-09-25 2022-03-02 Nanoplasmas Private Company, Diagnostic chip for analyzing presence of bacteria in a sample
WO2021067948A1 (en) * 2019-10-04 2021-04-08 Javelin Biotech, Inc. Neurodegenerative target discovery platform
CA3161454A1 (en) * 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
WO2021097205A1 (en) * 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
JP7759883B2 (en) 2020-02-20 2025-10-24 スタンダード バイオツールズ インコーポレイテッド Parallelized sample processing and library preparation
US12416043B2 (en) 2020-02-20 2025-09-16 Standard BioTools Inc. Parallelized sample processing and library prep
EP3957397A1 (en) * 2020-08-20 2022-02-23 Evorion Biotechnologies GmbH Microfabricated device, system and method comprising such system
WO2022040495A1 (en) * 2020-08-21 2022-02-24 Duke University Microfluidic assay device
US20230357822A1 (en) 2020-09-17 2023-11-09 Evorion Biotechnologies Gmbh Method for analyzing cell released biomolecules
US11485632B2 (en) 2020-10-09 2022-11-01 Arizona Board Of Regents On Behalf Of Arizona State University Modular 3-D printed devices for sample delivery and method
US11806713B2 (en) 2020-11-30 2023-11-07 Nexogen, Inc. Microfluidic system based on active control of flow resistance in microfluidic channels and methods of use thereof
CN114768894B (en) * 2021-01-22 2023-08-11 中国科学院上海微系统与信息技术研究所 Detection chip and detection method
CN118272228A (en) * 2024-02-07 2024-07-02 河北大学 Cell electrotaxis migration monitoring microfluidic chip, preparation method and monitoring method thereof
WO2025213101A1 (en) * 2024-04-04 2025-10-09 Cellular Vehicles Inc. Microfluidic systems, devices, and kits for suspension therapy preparation and/or infusion and methods for use
WO2025217338A1 (en) * 2024-04-11 2025-10-16 Bennubio, Inc. Systems and methods of serial enrichment and dilution (sed) to sort target cells

Family Cites Families (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656508A (en) 1949-08-27 1953-10-20 Wallace H Coulter Means for counting particles suspended in a fluid
US3560754A (en) 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3570515A (en) 1969-06-19 1971-03-16 Foxboro Co Aminar stream cross-flow fluid diffusion logic gate
NL7102074A (en) 1971-02-17 1972-08-21
FR2287606A1 (en) 1974-10-08 1976-05-07 Pegourie Jean Pierre PNEUMATIC LOGIC CIRCUITS AND THEIR INTEGRATED CIRCUITS
US4018565A (en) 1975-10-17 1977-04-19 The Foxboro Company Automatic process titration system
JPS5941169B2 (en) 1975-12-25 1984-10-05 シチズン時計株式会社 Elastomer
US4108565A (en) * 1977-07-21 1978-08-22 Jacobus Wilhelmus Janssen Potato processing
US4153855A (en) 1977-12-16 1979-05-08 The United States Of America As Represented By The Secretary Of The Army Method of making a plate having a pattern of microchannels
US4245673A (en) 1978-03-01 1981-01-20 La Telemechanique Electrique Pneumatic logic circuit
US4434704A (en) 1980-04-14 1984-03-06 Halliburton Company Hydraulic digital stepper actuator
US4585209A (en) 1983-10-27 1986-04-29 Harry E. Aine Miniature valve and method of making same
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5140161A (en) 1985-08-05 1992-08-18 Biotrack Capillary flow device
US4675300A (en) 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
US4990216A (en) 1987-10-27 1991-02-05 Fujitsu Limited Process and apparatus for preparation of single crystal of biopolymer
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US4898582A (en) 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
US5032381A (en) 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US4992312A (en) 1989-03-13 1991-02-12 Dow Corning Wright Corporation Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
CH679555A5 (en) 1989-04-11 1992-03-13 Westonbridge Int Ltd
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JPH04501449A (en) 1989-06-14 1992-03-12 ウエストンブリッジ　インターナショナル　リミティド micro pump
US5171132A (en) 1989-12-27 1992-12-15 Seiko Epson Corporation Two-valve thin plate micropump
US5327777A (en) 1990-02-24 1994-07-12 University Of Hertfordshire Biorheological measurement
DE4006152A1 (en) 1990-02-27 1991-08-29 Fraunhofer Ges Forschung MICROMINIATURIZED PUMP
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5096388A (en) 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
GB9008044D0 (en) 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
US5259737A (en) 1990-07-02 1993-11-09 Seiko Epson Corporation Micropump with valve structure
US6074818A (en) 1990-08-24 2000-06-13 The University Of Tennessee Research Corporation Fingerprinting of nucleic acids, products and methods
EP0498863B1 (en) 1990-08-31 1995-07-26 Westonbridge International Limited A valve equipped with a position detector and a micropump incorporating said valve
DE4119955C2 (en) 1991-06-18 2000-05-31 Danfoss As Miniature actuator
US5164558A (en) 1991-07-05 1992-11-17 Massachusetts Institute Of Technology Micromachined threshold pressure switch and method of manufacture
JP3328300B2 (en) 1991-07-18 2002-09-24 アイシン精機株式会社 Fluid control device
DE4127405C2 (en) 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Process for the separation of mixtures of microscopic dielectric particles suspended in a liquid or a gel and device for carrying out the process
DE4143343C2 (en) 1991-09-11 1994-09-22 Fraunhofer Ges Forschung Microminiaturized, electrostatically operated micromembrane pump
US5265327A (en) 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
GB2264296B (en) 1992-02-07 1995-06-28 Zortech Int Microporous thermal insulation material
US5558998A (en) 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
GB2264496B (en) 1992-02-25 1995-10-25 Us Energy Sizing of fragments from a nucleic acid sequence
JPH05236997A (en) 1992-02-28 1993-09-17 Hitachi Ltd Polynucleotide capture chip
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
DE4220077A1 (en) 1992-06-19 1993-12-23 Bosch Gmbh Robert Micro-pump for delivery of gases - uses working chamber warmed by heating element and controlled by silicon wafer valves.
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5364742A (en) 1992-09-21 1994-11-15 International Business Machines Corporation Micro-miniature structures and method of fabrication thereof
JP2812629B2 (en) 1992-11-25 1998-10-22 宇宙開発事業団 Crystal growth cell
US5290240A (en) 1993-02-03 1994-03-01 Pharmetrix Corporation Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5681024A (en) 1993-05-21 1997-10-28 Fraunhofer-Gesellschaft zur Forderung der angerwanden Forschung e.V. Microvalve
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
SE501713C2 (en) 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Diaphragm-type valve, especially for liquid handling blocks with micro-flow channels
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5642015A (en) 1993-07-14 1997-06-24 The University Of British Columbia Elastomeric micro electro mechanical systems
US5417235A (en) 1993-07-28 1995-05-23 Regents Of The University Of Michigan Integrated microvalve structures with monolithic microflow controller
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
EP0722541B1 (en) 1993-10-04 1998-12-30 Research International, Inc. Micromachined flow switches
CH689836A5 (en) 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropump.
EP0670489A3 (en) * 1994-03-03 1996-03-06 Ciba Geigy Ag Apparatus and method for the separation of fluids.
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
EP0695941B1 (en) 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
DE4433894A1 (en) 1994-09-22 1996-03-28 Fraunhofer Ges Forschung Method and device for controlling a micropump
DE69531430T2 (en) 1994-10-07 2004-07-01 Bayer Corp. relief valve
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
DE4438785C2 (en) 1994-10-24 1996-11-07 Wita Gmbh Wittmann Inst Of Tec Microchemical reaction and analysis unit
US5788468A (en) 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
JP3094880B2 (en) 1995-03-01 2000-10-03 住友金属工業株式会社 Method for controlling crystallization of organic compound and solid state element for controlling crystallization used therein
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5876187A (en) 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US5661222A (en) 1995-04-13 1997-08-26 Dentsply Research & Development Corp. Polyvinylsiloxane impression material
US5757482A (en) 1995-04-20 1998-05-26 Perseptive Biosystems, Inc. Module for optical detection in microscale fluidic analyses
DE19520298A1 (en) 1995-06-02 1996-12-05 Bayer Ag Sorting device for biological cells or viruses
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JPH0943251A (en) 1995-08-03 1997-02-14 Olympus Optical Co Ltd Dispenser
CA2183478C (en) 1995-08-17 2004-02-24 Stephen A. Carter Digital gas metering system using tri-stable and bi-stable solenoids
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6048734A (en) * 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5726751A (en) 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
JPH09149799A (en) 1995-11-30 1997-06-10 Hitachi Ltd Nucleic acid analysis method or inspection method, and nucleic acid analysis apparatus or inspection apparatus
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
KR100207410B1 (en) 1995-12-19 1999-07-15 전주범 Manufacturing method of optical path control device
US5660370A (en) 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5726404A (en) 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
FR2749663B1 (en) 1996-06-07 1998-07-31 Bio Merieux SINGLE USE ANALYSIS CARD COMPRISING A LIQUID FLOW CONDUIT
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
EP0909385B1 (en) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
CA2259395C (en) 1996-07-15 2002-03-05 Sumitomo Metal Industries, Ltd. Equipment for crystal growth and crystal-growing method using the same
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
EP0929658A4 (en) 1996-08-26 2005-11-02 Univ Princeton DEVICES FOR SORTING MICROSTRUCTURES THAT CAN BE REVERSIBLELY SEALED
US5738799A (en) 1996-09-12 1998-04-14 Xerox Corporation Method and materials for fabricating an ink-jet printhead
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5971355A (en) 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
US6117634A (en) 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
AU746892B2 (en) * 1997-04-04 2002-05-02 Caliper Life Sciences, Inc. Closed-loop biochemical analyzers
AU734957B2 (en) 1997-05-16 2001-06-28 Alberta Research Council Inc. Microfluidic system and methods of use
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
WO1999000655A2 (en) 1997-06-27 1999-01-07 Immunetics, Inc. Rapid flow-through binding assay apparatus and method
US5880690A (en) * 1997-07-15 1999-03-09 Exar Corporation Pipeline ADC common-mode tracking circuit
AU8492998A (en) 1997-07-16 1999-02-10 Diversified Scientific, Inc. Method for acquiring, storing and analyzing crystal images
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6540895B1 (en) * 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US7214298B2 (en) 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US5836750A (en) 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6345502B1 (en) 1997-11-12 2002-02-12 California Institute Of Technology Micromachined parylene membrane valve and pump
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
ATE364148T1 (en) 1998-01-20 2007-06-15 Invensys Sys Inc ELECTROMAGNET DEVICE WITH TWO OF THREE ELECTROMAGNETS THAT ARE ALWAYS ACTIVE
US6318970B1 (en) * 1998-03-12 2001-11-20 Micralyne Inc. Fluidic devices
WO1999052633A1 (en) 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
WO1999061888A2 (en) 1998-05-22 1999-12-02 California Institute Of Technology Microfabricated cell sorter
WO2000000678A1 (en) 1998-06-26 2000-01-06 University Of Washington Crystallization media
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
GB9822242D0 (en) * 1998-10-13 1998-12-09 Zeneca Ltd Device
RU2143343C1 (en) 1998-11-03 1999-12-27 Самсунг Электроникс Ко., Лтд. Microinjector and microinjector manufacture method
US6958865B1 (en) 1998-11-12 2005-10-25 California Institute Of Technology Microlicensing particles and applications
DE60034033T2 (en) 1999-04-06 2007-12-06 University of Alabama, Birmingham Research Foundation, Birmingham DEVICE FOR SCREENING CRYSTALLIZATION CONDITIONS IN SOLUTIONS FOR CRYSTAL BREEDING
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
EP1065378B1 (en) * 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
WO2001009595A2 (en) 1999-08-02 2001-02-08 Emerald Biostructures, Inc. Method and system for creating a crystallization results database
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
WO2001045843A2 (en) 1999-12-22 2001-06-28 Gene Logic, Inc. Flow-thru chip cartridge, chip holder, system and method thereof
WO2001067369A2 (en) 2000-03-03 2001-09-13 California Institute Of Technology Combinatorial array for nucleic acid analysis
EP1285106A2 (en) 2000-03-31 2003-02-26 Micronics, Inc. Protein crystallization in microfluidic structures
US20050118073A1 (en) 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6431212B1 (en) 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002000343A2 (en) 2000-06-27 2002-01-03 Fluidigm Corporation A microfluidic design automation method and system
US6885982B2 (en) 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
US7678547B2 (en) 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
US7097809B2 (en) 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
EP1322936A2 (en) 2000-10-03 2003-07-02 California Institute Of Technology Microfluidic devices and methods of use
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM USING A MICROFLUIDIC DEVICE, FOR ANALYSIS DEVICES
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
EP1345698A4 (en) 2000-11-16 2006-05-17 Fluidigm Corp MICROFLUIDIC DEVICES FOR THE INTRODUCTION AND RELEASE OF LIQUIDS FROM MICROFLUIDIC SYSTEMS
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
ATE500051T1 (en) 2001-04-06 2011-03-15 Fluidigm Corp POLYMER SURFACE MODIFICATION
US7075162B2 (en) 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
WO2003031163A2 (en) 2001-10-08 2003-04-17 California Institute Of Technology Microfabricated lenses, methods of manufacture thereof, and applications therefor
WO2003031066A1 (en) 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7059348B2 (en) 2002-05-13 2006-06-13 Fluidigm Corporation Drug delivery system
AU2003277853A1 (en) 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
JP2006501056A (en) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー Micro fluid large scale integration
JP5695287B2 (en) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー Nucleic acid analysis of microfluids
GB0302302D0 (en) 2003-01-31 2003-03-05 Glaxo Group Ltd Microfluidic apparatus and method
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
WO2004094020A2 (en) 2003-04-17 2004-11-04 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
US7695683B2 (en) 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
CA2532530A1 (en) 2003-07-28 2005-02-10 Fluidigm Corporation Image processing method and system for microfluidic devices
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7042649B2 (en) 2003-08-11 2006-05-09 California Institute Of Technology Microfabricated rubber microscope using soft solid immersion lenses
WO2005054441A2 (en) 2003-12-01 2005-06-16 California Institute Of Technology Device for immobilizing chemical and biomedical species and methods of using same
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
US7307802B2 (en) 2004-06-07 2007-12-11 Fluidigm Corporation Optical lens system and method for microfluidic devices
JP2008522795A (en) 2004-12-03 2008-07-03 カリフォルニア インスティチュート オブ テクノロジー Microfluidic device with chemical reaction circuit
US20080264863A1 (en) 2004-12-03 2008-10-30 California Institute Of Technology Microfluidic Sieve Valves
EP1882189A2 (en) 2005-04-20 2008-01-30 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20070054293A1 (en) 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US8206975B2 (en) 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
US20070248971A1 (en) 2006-01-26 2007-10-25 California Institute Of Technology Programming microfluidic devices with molecular information
US8039269B2 (en) 2006-01-26 2011-10-18 California Institute Of Technology Mechanically induced trapping of molecular interactions
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
EP2074341A4 (en) 2006-10-04 2013-04-10 Fluidigm Corp MICROFLUIDIC NO-RETURN VALVES
WO2008067552A2 (en) 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
WO2008141183A2 (en) 2007-05-09 2008-11-20 Fluidigm Corporation Method and system for crystallization and x-ray diffraction screening
CN101821619B (en) 2007-09-07 2015-02-11 弗卢丁公司 Copy number variation determination, methods and systems
WO2009100449A1 (en) 2008-02-08 2009-08-13 Fluidigm Corporation Dynamic array assay methods
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
US9579830B2 (en) 2008-07-25 2017-02-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
WO2010017210A1 (en) 2008-08-07 2010-02-11 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
CN105964316A (en) 2008-12-08 2016-09-28 富鲁达公司 Programmable microfluidic digital array
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
WO2011053790A2 (en) 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis

Also Published As

Publication number Publication date
JP2003536058A (en) 2003-12-02
US8257666B2 (en) 2012-09-04
WO2001094635A9 (en) 2002-08-08
US7351376B1 (en) 2008-04-01
US7622081B2 (en) 2009-11-24
US20130295653A1 (en) 2013-11-07
US8129176B2 (en) 2012-03-06
WO2001094635A3 (en) 2002-10-31
US20120178084A1 (en) 2012-07-12
US20020037499A1 (en) 2002-03-28
US6767706B2 (en) 2004-07-27
US20100120018A1 (en) 2010-05-13
US20040248167A1 (en) 2004-12-09
US20160339423A1 (en) 2016-11-24
EP1290226A2 (en) 2003-03-12
US20150031116A1 (en) 2015-01-29
WO2001094635A2 (en) 2001-12-13

Similar Documents

Publication Publication Date Title
AU2001275340A1 (en) Integrated active flux microfluidic devices and methods
AU2001247478A1 (en) Microlaboratory devices and methods
AU2002211389A1 (en) Microfluidic devices and methods of use
AU2001286419A1 (en) Endourethral device and method
AU2002227414A1 (en) Infusion devices and method
AU2001267079A1 (en) Integrated electronic-optoelectronic devices and method of making the same
AU5499201A (en) Microfluidic devices
AU2002218752A1 (en) Methods and devices for nebulizing fluids
AU2001247770A1 (en) Biased rotatable combdrive devices and methods
AU2002219163A1 (en) Cryostorage method and device
AU2002245675A1 (en) Electromanipulation device and method
AU2002211717A1 (en) Stresscopins and their uses
MXPA03003796A (en) Pour-on application method and devices.
AU2001292936A1 (en) Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
AU2001276269A1 (en) Tool and associated fixing device
AU3230801A (en) Semiconductor device fabrication method and semiconductor device fabrication device
AU2001274521A1 (en) Receiving device and receiving method
AU3205501A (en) Tattooing device
AU2001242793A1 (en) Semiconductor device and fabrication method therefor
AU2001295185A1 (en) Multiplexing-interleaving and demultiplexing-deinterleaving
AU2001292329A1 (en) Path selection device and path selection method
AU2001269495A1 (en) Business-use laundering method and business-use laundering device using the method
AU2002222749A1 (en) Orthodontics device and method
AU2001252062A1 (en) Steatosis-modulating factors and uses thereof
AU2001292366A1 (en) Receiving device and receiving method