AU2001275294A1 - Immunostimulatory RNA/DNA hybrid molecules - Google Patents

Immunostimulatory RNA/DNA hybrid molecules

Info

Publication number: AU2001275294A1
Authority: AU; Australia
Prior art keywords: seq; rna; oligonucleotide; cells; dna
Prior art date: 2000-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001275294A

Other languages

English (en)

Inventor

Michael Flora

Dennis M. Klinman

James J. Mond

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biosynexus Inc

Henry M Jackson Foundation for Advancedment of Military Medicine Inc

US Department of Health and Human Services

Original Assignee

Biosynexus Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-07

Filing date

2001-06-07

Publication date

2001-12-17

2001-06-07 Application filed by Biosynexus Inc filed Critical Biosynexus Inc

2001-12-17 Publication of AU2001275294A1 publication Critical patent/AU2001275294A1/en

Status Abandoned legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Mycology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AU2001275294A 2000-06-07 2001-06-07 Immunostimulatory RNA/DNA hybrid molecules Abandoned AU2001275294A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20979700P	2000-06-07	2000-06-07
US60209797		2000-06-07
PCT/US2001/018276 WO2001093902A2 (fr)	2000-06-07	2001-06-07	Molecules hybrides arn/adn immunostimulatrices

Publications (1)

Publication Number	Publication Date
AU2001275294A1 true AU2001275294A1 (en)	2001-12-17

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AU2001275294A Abandoned AU2001275294A1 (en)	2000-06-07	2001-06-07	Immunostimulatory RNA/DNA hybrid molecules

Country Status (6)

Country	Link
US (1)	US20040052763A1 (fr)
EP (1)	EP1292331A2 (fr)
JP (1)	JP2004530629A (fr)
AU (1)	AU2001275294A1 (fr)
CA (1)	CA2412026A1 (fr)
WO (1)	WO2001093902A2 (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6207646B1 (en) *	1994-07-15	2001-03-27	University Of Iowa Research Foundation	Immunostimulatory nucleic acid molecules
AU2001227889A1 (en) *	2000-01-14	2001-07-24	The United States of America, represented by The Secretary, Department of Health & Human Services	Oligodeoxynucleotide and its use to induce an immune response
DE50214201D1 (de)	2001-06-05	2010-03-25	Curevac Gmbh	Stabilisierte mRNA mit erhöhtem G/C-Gehalt, enkodierend für ein bakterielles Antigen sowie deren Verwendung
AU2002345847B2 (en)	2001-06-21	2008-05-29	Dynavax Technologies Corporation	Chimeric immunomodulatory compounds and methods of using the same
DE10162480A1 (de)	2001-12-19	2003-08-07	Ingmar Hoerr	Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
JP2005526778A (ja) *	2002-03-15	2005-09-08	アストラル，インコーポレイテッド	免疫調節性非コードｒｎａモチーフを用いて抗体及び主要組織適合性クラスｉ拘束性又はクラスｉｉ拘束性ｔ細胞の応答を開始或いは増強させるための組成物及び方法
US20070037769A1 (en) *	2003-03-14	2007-02-15	Multicell Immunotherapeutics, Inc.	Compositions and methods to treat and control tumors by loading antigen presenting cells
EP2258712A3 (fr) *	2002-03-15	2011-05-04	Multicell Immunotherapeutics, Inc.	Compositions et procédés permettant d'initier ou d'ameliorer les réponses des cellules T limitées par le complexe majeur d 'histocompatibilité de classe I ou II et un anticorps au moyen de motifs d'ARN non codants immunomodulateurs
US8153141B2 (en) *	2002-04-04	2012-04-10	Coley Pharmaceutical Gmbh	Immunostimulatory G, U-containing oligoribonucleotides
DE10229872A1 (de) *	2002-07-03	2004-01-29	Curevac Gmbh	Immunstimulation durch chemisch modifizierte RNA
US8263091B2 (en) *	2002-09-18	2012-09-11	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
WO2004053104A2 (fr)	2002-12-11	2004-06-24	Coley Pharmaceutical Group, Inc.	Acides nucleiques 5'cpg et leurs methodes d'utilisation
PT1575977E (pt)	2002-12-23	2009-12-15	Dynavax Tech Corp	Oligonucleótidos de sequência imunoestimuladora e métodos de utilização dos mesmos
US8158768B2 (en)	2002-12-23	2012-04-17	Dynavax Technologies Corporation	Immunostimulatory sequence oligonucleotides and methods of using the same
WO2004100965A1 (fr) *	2003-05-15	2004-11-25	Japan Science And Technology Agency	Immunostimulant
DE10347710B4 (de)	2003-10-14	2006-03-30	Johannes-Gutenberg-Universität Mainz	Rekombinante Impfstoffe und deren Verwendung
TW200533750A (en) *	2004-02-19	2005-10-16	Coley Pharm Group Inc	Immunostimulatory viral RNA oligonucleotides
AU2011203218B2 (en) *	2004-12-09	2013-02-07	Alnylam Pharmaceuticals, Inc.	Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
AU2005313883B2 (en) *	2004-12-09	2011-03-31	Alnylam Pharmaceuticals, Inc.	Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
WO2006116458A2 (fr) *	2005-04-26	2006-11-02	Coley Pharmaceutical Gmbh	Analogues d'oligoribonucleotides modifies presentant une activite d'immunostimulation amelioree
JP2010503608A (ja) *	2005-09-16	2010-02-04	コーリーファーマシューティカルゲーエムベーハー	ホスホジエステルバックボーンを有する免疫刺激性一本鎖リボ核酸
DE102005046490A1 (de)	2005-09-28	2007-03-29	Johannes-Gutenberg-Universität Mainz	Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
EP1948818A4 (fr) *	2005-10-28	2009-02-11	Centocor Inc	Utilisation d'agents d'expansion de cellules b dans la generation d'anticorps
WO2007062107A2 (fr)	2005-11-25	2007-05-31	Coley Pharmaceutical Gmbh	Oligoribonucleotides immunostimulateurs
JP2010507361A (ja)	2006-07-31	2010-03-11	キュアバックゲーエムベーハー	具体的には免疫刺激剤／アジュバントとしての、一般式（Ｉ）：ＧｌＸｍＧｎ、または一般式（ＩＩ）：ＣｌＸｍＣｎで表される核酸
DE102006035618A1 (de) *	2006-07-31	2008-02-07	Curevac Gmbh	Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz
MX2009003398A (es)	2006-09-27	2009-08-12	Coley Pharm Gmbh	Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
WO2009030254A1 (fr)	2007-09-04	2009-03-12	Curevac Gmbh	Complexes d'arn et de peptides cationiques pour transfection et immunostimulation
MX2010008468A (es)	2008-01-31	2010-08-30	Curevac Gmbh	Acidos nucleicos de la formula (i) (nug1xmgnnv)a y derivados de los mismos como un agente/adyuvante inmunoestimulante.
WO2010037408A1 (fr)	2008-09-30	2010-04-08	Curevac Gmbh	Composition comprenant un arnm complexé et un arnm nu pour déclencher ou augmenter une réponse immunostimulante chez un mammifère et utilisations de ladite composition
US20110053829A1 (en)	2009-09-03	2011-03-03	Curevac Gmbh	Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
CA2801523C (fr)	2010-07-30	2021-08-03	Curevac Gmbh	Complexation d'acides nucleiques avec des composants cationiques reticules par un pont disulfure pour une transfection et une immunostimulation
CA2807552A1 (fr)	2010-08-06	2012-02-09	Moderna Therapeutics, Inc.	Acides nucleiques modifies et leurs procedes d'utilisation
EP3431485B2 (fr)	2010-10-01	2024-09-04	ModernaTX, Inc.	Acides nucléiques techniques et leurs procédés d'utilisation
WO2012135805A2 (fr)	2011-03-31	2012-10-04	modeRNA Therapeutics	Administration et formulation d'acides nucléiques génétiquement modifiés
MX360823B (es)	2011-05-24	2018-11-16	Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh	Vacunas individualizadas para el cancer.
FR2975600B1 (fr)	2011-05-24	2013-07-05	Assist Publ Hopitaux De Paris	Agents pour le traitement de tumeurs
US9464124B2 (en)	2011-09-12	2016-10-11	Moderna Therapeutics, Inc.	Engineered nucleic acids and methods of use thereof
EP2763701B1 (fr)	2011-10-03	2018-12-19	Moderna Therapeutics, Inc.	Nucléosides, nucléotides et acides nucléiques modifiés, et leurs utilisations
KR20140102759A (ko)	2011-12-16	2014-08-22	모더나 세라퓨틱스, 인코포레이티드	변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
WO2013113326A1 (fr)	2012-01-31	2013-08-08	Curevac Gmbh	Composition pharmaceutique comprenant un complexe support polymère - charge et au moins un antigène de protéine ou de peptide
WO2013143555A1 (fr)	2012-03-26	2013-10-03	Biontech Ag	Formulation d'arn pour immunothérapie
DE18200782T1 (de)	2012-04-02	2021-10-21	Modernatx, Inc.	Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9283287B2 (en)	2012-04-02	2016-03-15	Moderna Therapeutics, Inc.	Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en)	2012-04-02	2017-02-21	Modernatx, Inc.	Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en)	2012-04-02	2018-01-30	Modernatx, Inc.	Modified polynucleotides for the production of cosmetic proteins and peptides
CA2892529C (fr)	2012-11-26	2023-04-25	Moderna Therapeutics, Inc.	Arn modifie a son extremite terminale
JP6484558B2 (ja)	2012-11-28	2019-03-13	バイオエヌテックエールエヌアーファーマシューティカルズゲーエムベーハーＢｉｏｎｔｅｃｈＲｎａＰｈａｒｍａｃｅｕｔｉｃａｌｓＧｍｂｈ	癌ワクチンの組み合せ物
US8980864B2 (en)	2013-03-15	2015-03-17	Moderna Therapeutics, Inc.	Compositions and methods of altering cholesterol levels
WO2014180490A1 (fr)	2013-05-10	2014-11-13	Biontech Ag	Prédiction de l'immunogénicité d'épitopes de lymphocytes t
ES2747762T3 (es)	2013-08-21	2020-03-11	Curevac Ag	Vacuna contra el virus respiratorio sincitial (RSV)
US10023626B2 (en)	2013-09-30	2018-07-17	Modernatx, Inc.	Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru)	2013-10-03	2016-08-31	Модерна Терапьютикс, Инк.	Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
ES2806575T3 (es)	2013-11-01	2021-02-18	Curevac Ag	ARN modificado con propiedades inmunoestimuladoras disminuidas
WO2015149944A2 (fr)	2014-04-01	2015-10-08	Curevac Gmbh	Complexe cargo de support polymère à utiliser comme agent immunostimulant ou comme adjuvant
WO2016045732A1 (fr)	2014-09-25	2016-03-31	Biontech Rna Pharmaceuticals Gmbh	Formulations stables de lipides et de liposomes
EP3238727B1 (fr) *	2014-12-25	2023-01-18	National Institutes of Biomedical Innovation, Health and Nutrition	Oligonucléotide immunostimulant sans cohésion
WO2016128060A1 (fr)	2015-02-12	2016-08-18	Biontech Ag	Prédiction des épitopes de lymphocytes t utiles pour la vaccination
WO2017059902A1 (fr)	2015-10-07	2017-04-13	Biontech Rna Pharmaceuticals Gmbh	Séquences utr 3' permettant la stabilisation d'arn
WO2018224166A1 (fr)	2017-06-09	2018-12-13	Biontech Rna Pharmaceuticals Gmbh	Procédés de prédiction de l'utilité de modifications d'acides aminés spécifiques d'une maladie pour l'immunothérapie

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5708154A (en) *	1989-02-24	1998-01-13	City Of Hope	RNA-DNA hybrid molecules of nucleic acid
WO1991019789A1 (fr) *	1990-06-19	1991-12-26	Commonwealth Scientific And Industrial Research Organisation	Endonucleases
US5932717A (en) *	1994-09-29	1999-08-03	Asafov; Alexandr V.	Methods of obtaining DNA-RNA hybrids from sturgeon milt
US6632923B1 (en) *	1996-11-27	2003-10-14	Boston Heart Foundation, Inc.	Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
US6262334B1 (en) *	1998-08-31	2001-07-17	Bayer Corporation	Human genes and expression products: II
CA2311201A1 (fr) *	1999-08-05	2001-02-05	Genset S.A.	Sequences marqueurs exprimees et proteines humaines codees
WO2001055341A2 (fr) *	2000-01-31	2001-08-02	The Regents Of The University Of California	Polynucleotides immunomodulateurs dans le traitement d'une infection par un pathogene intracellulaire
US7585847B2 (en) *	2000-02-03	2009-09-08	Coley Pharmaceutical Group, Inc.	Immunostimulatory nucleic acids for the treatment of asthma and allergy
WO2001062207A2 (fr) *	2000-02-23	2001-08-30	The Regents Of The University Of California	Methode de traitement des maladies intestinales inflammatoires et d'autres formes d'inflammation gastro-intestinale
EP1267618A1 (fr) *	2000-03-28	2003-01-02	The Regents Of The University Of California	Procedes pour augmenter une reaction de lymphocytes t cytotoxiques in vivo
AU2001276331A1 (en) *	2000-04-06	2001-10-23	Epigenomics Ag	Diagnosis of diseases associated with metastasis
US7534772B2 (en) *	2000-06-22	2009-05-19	University Of Iowa Research Foundation	Methods for enhancing antibody-induced cell lysis and treating cancer
US20030050268A1 (en) *	2001-03-29	2003-03-13	Krieg Arthur M.	Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases

2001
- 2001-06-07 WO PCT/US2001/018276 patent/WO2001093902A2/fr not_active Ceased
- 2001-06-07 JP JP2002501473A patent/JP2004530629A/ja active Pending
- 2001-06-07 US US09/874,991 patent/US20040052763A1/en not_active Abandoned
- 2001-06-07 CA CA002412026A patent/CA2412026A1/fr not_active Abandoned
- 2001-06-07 AU AU2001275294A patent/AU2001275294A1/en not_active Abandoned
- 2001-06-07 EP EP01941989A patent/EP1292331A2/fr not_active Withdrawn

Also Published As

Publication number	Publication date
CA2412026A1 (fr)	2001-12-13
US20040052763A1 (en)	2004-03-18
EP1292331A2 (fr)	2003-03-19
WO2001093902A2 (fr)	2001-12-13
WO2001093902A3 (fr)	2002-04-18
JP2004530629A (ja)	2004-10-07

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2007-01-25	MK4	Application lapsed section 142(2)(d) - no continuation fee paid for the application