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AU2001275267A1 - Leader peptides for enhancing secretion of recombinant protein from a host cell - Google Patents

Leader peptides for enhancing secretion of recombinant protein from a host cell

Info

Publication number
AU2001275267A1
AU2001275267A1 AU2001275267A AU7526701A AU2001275267A1 AU 2001275267 A1 AU2001275267 A1 AU 2001275267A1 AU 2001275267 A AU2001275267 A AU 2001275267A AU 7526701 A AU7526701 A AU 7526701A AU 2001275267 A1 AU2001275267 A1 AU 2001275267A1
Authority
AU
Australia
Prior art keywords
leader peptides
host cell
recombinant protein
enhancing secretion
secretion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001275267A
Inventor
Tseng-Hui T. Chen
Brian Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of AU2001275267A1 publication Critical patent/AU2001275267A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel synthetic leader peptides have been identified. The leader peptides have use in a method of enhancing the secretion of a recombinant polypeptide produced in a host cell. Polynucleotides encoding the novel leader peptides and a method of designing the polynucleotides are described.
AU2001275267A 2000-06-05 2001-06-05 Leader peptides for enhancing secretion of recombinant protein from a host cell Abandoned AU2001275267A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20951700P 2000-06-05 2000-06-05
US60/209,517 2000-06-05
PCT/US2001/018222 WO2001094418A2 (en) 2000-06-05 2001-06-05 Leader peptides for enhancing secretion of recombinant protein from a host cell

Publications (1)

Publication Number Publication Date
AU2001275267A1 true AU2001275267A1 (en) 2001-12-17

Family

ID=22779048

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001275267A Abandoned AU2001275267A1 (en) 2000-06-05 2001-06-05 Leader peptides for enhancing secretion of recombinant protein from a host cell

Country Status (9)

Country Link
US (1) US6875590B2 (en)
EP (1) EP1290197B1 (en)
JP (1) JP2004510410A (en)
AT (1) ATE321870T1 (en)
AU (1) AU2001275267A1 (en)
CA (1) CA2412374A1 (en)
DE (1) DE60118370T2 (en)
ES (1) ES2263626T3 (en)
WO (1) WO2001094418A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099996A2 (en) * 2002-05-22 2003-12-04 Biogen Idec Ma Inc. Detection of secreted polypeptides
EP2316857A1 (en) * 2004-02-12 2011-05-04 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
EP3540062B1 (en) 2004-11-16 2021-05-12 Humanigen, Inc. Immunoglobulin variable region cassette exchange
WO2006099141A2 (en) 2005-03-10 2006-09-21 Morphotek, Inc. Anti-mesothelin antibodies
JP5167813B2 (en) * 2005-05-12 2013-03-21 味の素株式会社 Protein production method
US7393671B2 (en) 2006-03-30 2008-07-01 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolases
DE102006044841A1 (en) 2006-09-22 2008-04-03 Wacker Chemie Ag Signal peptide for the production of recombinant proteins
CA2729839A1 (en) * 2008-07-03 2010-01-07 Diane Retallack High throughput screening method and use thereof to identify a production platform for a multifunctional binding protein
US20100093563A1 (en) * 2008-09-22 2010-04-15 Robert Anthony Williamson Methods and vectors for display of molecules and displayed molecules and collections
AU2010322205B2 (en) * 2009-11-17 2015-01-22 Janssen Biotech, Inc. Improved bacterial membrane protein secretion
JP2014045730A (en) * 2012-08-31 2014-03-17 Meiji Univ Polypeptide, gene, expression vector, method for transporting protein to endoplasmic reticulum, and method for designing signal peptide
JP6952603B2 (en) 2015-02-10 2021-10-20 オハイオ・ステイト・イノベーション・ファウンデーション Chlamydia activated B cell platform and methods thereof
US10835601B2 (en) 2015-11-10 2020-11-17 Ohio State Innovation Foundation Methods and compositions related to accelerated humoral affinity
EP3600401A1 (en) * 2017-03-23 2020-02-05 Ohio State Innovation Foundation Recombinant chlamydia-activated b cell platforms and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757013A (en) 1983-07-25 1988-07-12 The Research Foundation Of State University Of New York Cloning vehicles for polypeptide expression in microbial hosts
CA1341235C (en) * 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
FR2636643B1 (en) * 1988-08-24 1990-12-28 Sanofi Sa PEPTIDE-SIGNAL, DNA SEQUENCES ENCODING SAME, EXPRESSION VECTORS CARRYING ONE OF SUCH SEQUENCES, AND METHOD FOR PERIPLASMIC PRODUCTION OF A POLYPEPTIDE
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
EP0626448A3 (en) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Process for preparing and purifying alpha-interferon
US5470719A (en) 1994-03-18 1995-11-28 Meng; Shi-Yuan Modified OmpA signal sequence for enhanced secretion of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5747662A (en) 1995-03-01 1998-05-05 Genentech, Inc. Methods and compositions for secretion of heterologous polypeptides
EP1307211A4 (en) * 2000-03-22 2005-01-05 Corixa Corp Immune mediators and related methods
US20020082411A1 (en) * 2001-01-23 2002-06-27 Darrick Carter Immune mediators and related methods

Also Published As

Publication number Publication date
US20020072093A1 (en) 2002-06-13
ES2263626T3 (en) 2006-12-16
CA2412374A1 (en) 2001-12-13
EP1290197B1 (en) 2006-03-29
DE60118370D1 (en) 2006-05-18
JP2004510410A (en) 2004-04-08
WO2001094418A2 (en) 2001-12-13
DE60118370T2 (en) 2006-12-07
ATE321870T1 (en) 2006-04-15
US6875590B2 (en) 2005-04-05
EP1290197A2 (en) 2003-03-12
WO2001094418A3 (en) 2002-09-26

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