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AU2001274088A1 - Screening-method for modulators of methyltransferase-dependent chromosome stability - Google Patents

Screening-method for modulators of methyltransferase-dependent chromosome stability

Info

Publication number
AU2001274088A1
AU2001274088A1 AU2001274088A AU7408801A AU2001274088A1 AU 2001274088 A1 AU2001274088 A1 AU 2001274088A1 AU 2001274088 A AU2001274088 A AU 2001274088A AU 7408801 A AU7408801 A AU 7408801A AU 2001274088 A1 AU2001274088 A1 AU 2001274088A1
Authority
AU
Australia
Prior art keywords
modulators
suv39h2
screening
methyltransferase
chromosome stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001274088A
Inventor
Frank Eisenhaber
Thomas Jenuwein
Donal O'carroll
Stephen Rea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00112479A external-priority patent/EP1162460A1/en
Priority claimed from EP00112345A external-priority patent/EP1162274A1/en
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU2001274088A1 publication Critical patent/AU2001274088A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
    • G01N2333/91011—Methyltransferases (general) (2.1.1.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Murine and human Suv39h2 polypeptide and DNA molecules encoding them. <i>Suv39h2</i> is a novel member of the <i>Suv3-9</i> gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with Suv39h1, for male gametogenesis. Sub39h2 can be used in screening methods to identify modulators of its methyltransferase activity, which are useful in cancer therapy and for male contraception.
AU2001274088A 2000-06-09 2001-06-07 Screening-method for modulators of methyltransferase-dependent chromosome stability Abandoned AU2001274088A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP00112479 2000-06-09
EP00112479A EP1162460A1 (en) 2000-06-09 2000-06-09 Mammalian Suv39h2 proteins and isolated DNA molecules encoding them
EP00112345 2000-06-09
EP00112345A EP1162274A1 (en) 2000-06-09 2000-06-09 Method for identifying compounds modifying methyltransferase-dependent chromosome stability
PCT/EP2001/006485 WO2001094620A1 (en) 2000-06-09 2001-06-07 Screening-method for modulators of methyltransferase-dependent chromosome stability

Publications (1)

Publication Number Publication Date
AU2001274088A1 true AU2001274088A1 (en) 2001-12-17

Family

ID=26071033

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001274088A Abandoned AU2001274088A1 (en) 2000-06-09 2001-06-07 Screening-method for modulators of methyltransferase-dependent chromosome stability
AU2001266055A Abandoned AU2001266055A1 (en) 2000-06-09 2001-06-08 Screening method for modulators of suv39h2-methyltransferase

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001266055A Abandoned AU2001266055A1 (en) 2000-06-09 2001-06-08 Screening method for modulators of suv39h2-methyltransferase

Country Status (7)

Country Link
EP (2) EP1294927B1 (en)
JP (2) JP4896344B2 (en)
AT (1) ATE310100T1 (en)
AU (2) AU2001274088A1 (en)
DE (1) DE60115039T2 (en)
ES (1) ES2252240T3 (en)
WO (2) WO2001094620A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2471385A1 (en) * 2001-12-27 2003-07-10 Takeda Chemical Industries, Ltd. Preventives/remedies for cancer
GB0301450D0 (en) * 2003-01-22 2003-02-19 Medical Res Council Protein crystal structure
JP3913181B2 (en) * 2003-02-06 2007-05-09 三菱重工業株式会社 Carbon nanofiber manufacturing method and manufacturing apparatus
JP5451376B2 (en) * 2007-03-15 2014-03-26 株式会社リバース・プロテオミクス研究所 Biomarkers specific for blood cell lineage or specific for osteoclast differentiation
US20140094387A1 (en) * 2011-06-03 2014-04-03 Oncotherapy Science, Inc. Suv39h2 as a target gene for cancer therapy and diagnosis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69836197T2 (en) * 1997-08-29 2007-09-06 Innogenetics N.V. METHYLATED SMD HOMOLOGOUS PEPTIDES THAT RESPOND WITH ANTIBODIES FROM SERA OF LIVING WITH SYSTEMIC LUPUS ERYTHEMATODES

Also Published As

Publication number Publication date
WO2001094621A1 (en) 2001-12-13
WO2001094620A1 (en) 2001-12-13
ES2252240T3 (en) 2006-05-16
DE60115039T2 (en) 2006-07-27
DE60115039D1 (en) 2005-12-22
JP4896344B2 (en) 2012-03-14
EP1294928A1 (en) 2003-03-26
EP1294927A1 (en) 2003-03-26
JP2003535595A (en) 2003-12-02
ATE310100T1 (en) 2005-12-15
AU2001266055A1 (en) 2001-12-17
EP1294927B1 (en) 2005-11-16
JP2003535596A (en) 2003-12-02

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