[go: up one dir, main page]

AU2001273057A1 - A microfluidic design automation method and system - Google Patents

A microfluidic design automation method and system

Info

Publication number
AU2001273057A1
AU2001273057A1 AU2001273057A AU7305701A AU2001273057A1 AU 2001273057 A1 AU2001273057 A1 AU 2001273057A1 AU 2001273057 A AU2001273057 A AU 2001273057A AU 7305701 A AU7305701 A AU 7305701A AU 2001273057 A1 AU2001273057 A1 AU 2001273057A1
Authority
AU
Australia
Prior art keywords
design automation
automation method
microfluidic design
microfluidic
design
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001273057A
Other languages
English (en)
Inventor
Gregory Harris
Michael Lee
James Montgomery
Gajus Worthington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Standard Biotools Inc
Original Assignee
Fluidigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidigm Corp filed Critical Fluidigm Corp
Publication of AU2001273057A1 publication Critical patent/AU2001273057A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/56General build-up of the mixers
    • B01F35/561General build-up of the mixers the mixer being built-up from a plurality of modules or stacked plates comprising complete or partial elements of the mixer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00Devices without movable or flexible elements, e.g. microcapillary devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81CPROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00Subject matter not provided for in other groups of this subclass
    • B81C99/0055Manufacturing logistics
    • B81C99/006Design; Simulation
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00Computer-aided design [CAD]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00Computer-aided design [CAD]
    • G06F30/10Geometric CAD
    • G06F30/18Network design, e.g. design based on topological or interconnect aspects of utility systems, piping, heating ventilation air conditioning [HVAC] or cabling
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00993Design aspects
    • B01J2219/00997Strategical arrangements of multiple microreactor systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F2111/00Details relating to CAD techniques
    • G06F2111/10Numerical modelling
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F2115/00Details relating to the type of the circuit
    • G06F2115/04Micro electro-mechanical systems [MEMS]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01HELECTRIC SWITCHES; RELAYS; SELECTORS; EMERGENCY PROTECTIVE DEVICES
    • H01H29/00Switches having at least one liquid contact
    • H01H2029/008Switches having at least one liquid contact using micromechanics, e.g. micromechanical liquid contact switches or [LIMMS]

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Geometry (AREA)
  • General Physics & Mathematics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Evolutionary Computation (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Pure & Applied Mathematics (AREA)
  • Computational Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Design And Manufacture Of Integrated Circuits (AREA)
AU2001273057A 2000-06-27 2001-06-27 A microfluidic design automation method and system Abandoned AU2001273057A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21459500P 2000-06-27 2000-06-27
US60214595 2000-06-27
PCT/US2001/020639 WO2002000343A2 (fr) 2000-06-27 2001-06-27 Procede et systeme d'automatisation de conception de systemes microfluidiques

Publications (1)

Publication Number Publication Date
AU2001273057A1 true AU2001273057A1 (en) 2002-01-08

Family

ID=22799693

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001273057A Abandoned AU2001273057A1 (en) 2000-06-27 2001-06-27 A microfluidic design automation method and system

Country Status (3)

Country Link
US (4) US7062418B2 (fr)
AU (1) AU2001273057A1 (fr)
WO (1) WO2002000343A2 (fr)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
EP1065378B1 (fr) 1999-06-28 2002-04-03 California Institute of Technology Systemes de micropompes et microsoupapes elastomeriques
US8052792B2 (en) * 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US7306672B2 (en) * 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (fr) 1999-11-26 2001-05-26 D. Jed Harrison Appareil et methode de piegeage de reactifs en forme de perles, dans le cadre d'un systeme d'analyse de microfluides
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002000343A2 (fr) * 2000-06-27 2002-01-03 Fluidigm Corporation Procede et systeme d'automatisation de conception de systemes microfluidiques
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
EP1322936A2 (fr) * 2000-10-03 2003-07-02 California Institute Of Technology Dispositifs microfluidiques et procedes d'utilisation
EP1336097A4 (fr) 2000-10-13 2006-02-01 Fluidigm Corp Systeme d'injection d'echantillons utilisant un dispositif microfluidique, pour dispositifs d'analyse
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7130783B1 (en) * 2001-01-12 2006-10-31 Synopsys, Inc. Simulation-based functional verification of microcircuit designs
US6925390B2 (en) * 2001-01-15 2005-08-02 Sau Lan Tang Staats Customized microfluidic device design, ordering, and manufacturing
CA2440754A1 (fr) 2001-03-12 2002-09-19 Stephen Quake Procedes et appareil d'analyse de sequences de polynucleotide par extension de base asynchrone
WO2002081729A2 (fr) 2001-04-06 2002-10-17 California Institute Of Technology Amplification d'acide nucleique au moyen de dispositifs microfluidiques
US20050149304A1 (en) * 2001-06-27 2005-07-07 Fluidigm Corporation Object oriented microfluidic design method and system
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
EP1428031B1 (fr) * 2001-09-17 2010-07-28 Gyros Patent Ab Programme de traitement de procedes pour instruments microfluidiques
WO2003031066A1 (fr) 2001-10-11 2003-04-17 California Institute Of Technology Dispositifs utilisant du gel auto-assemble et procede de fabrication associe
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US20030225555A1 (en) * 2002-05-31 2003-12-04 Lalitha Gurumoorthy Component system design method and apparatus
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
AU2003277853A1 (en) * 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
JP2006501056A (ja) * 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
CN100380034C (zh) 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用装置和方法
US20040122630A1 (en) * 2002-12-19 2004-06-24 Wallace Ronald Hugh Fife Method and apparatus for linking finite element models to computer-aided design models
KR101216828B1 (ko) 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
US7137082B1 (en) * 2003-03-28 2006-11-14 Magma Design Automation Inc. Reduced architecture processing paths
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7695683B2 (en) * 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7062740B2 (en) * 2003-05-22 2006-06-13 Taiwan Semiconductor Manufacturing Co., Ltd. System and method for reducing design cycle time for designing input/output cells
CA2532530A1 (fr) 2003-07-28 2005-02-10 Fluidigm Corporation Procede de traitement d'image et systeme pour dispositifs microfluidiques
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7093211B1 (en) * 2003-11-03 2006-08-15 General Electric Company Techniques for modeling current spreading uniformity in light emitting diodes
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
DE602005027700D1 (de) 2004-05-25 2011-06-09 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
JP4345576B2 (ja) 2004-05-26 2009-10-14 ヤマハ株式会社 信号経路設定装置および信号経路設定プログラム
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US8095903B2 (en) 2004-06-01 2012-01-10 Pulsic Limited Automatically routing nets with variable spacing
US7307802B2 (en) 2004-06-07 2007-12-11 Fluidigm Corporation Optical lens system and method for microfluidic devices
US7571082B2 (en) * 2004-06-22 2009-08-04 Wells Fargo Bank, N.A. Common component modeling
US7386825B2 (en) * 2004-07-29 2008-06-10 International Business Machines Corporation Method, system and program product supporting presentation of a simulated or hardware system including configuration entities
US7389490B2 (en) * 2004-07-29 2008-06-17 International Business Machines Corporation Method, system and program product for providing a configuration specification language supporting selective presentation of configuration entities
EP1794581A2 (fr) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Dispositifs microfluidiques
JP4787488B2 (ja) * 2004-11-19 2011-10-05 独立行政法人理化学研究所 直鎖状鋳型dnaを用いた無細胞タンパク質合成方法及びそのための細胞抽出液
JP2008522795A (ja) * 2004-12-03 2008-07-03 カリフォルニア インスティチュート オブ テクノロジー 化学反応回路を有するマイクロ流体装置
US20080264863A1 (en) 2004-12-03 2008-10-30 California Institute Of Technology Microfluidic Sieve Valves
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US20060204383A1 (en) * 2005-03-08 2006-09-14 Hiroyuki Kushida Electric vacuum cleaner
US7493578B1 (en) * 2005-03-18 2009-02-17 Xilinx, Inc. Correlation of data from design analysis tools with design blocks in a high-level modeling system
EP1882189A2 (fr) 2005-04-20 2008-01-30 Fluidigm Corporation Moteur d'analyse et base de donnees permettant de manipuler des parametres destines a des systemes fluidiques sur une puce
EP1722295A1 (fr) * 2005-05-10 2006-11-15 Siemens Aktiengesellschaft Procédé, dispositif et produit programme d'ordinateur pour fournir d'information utilisateur dans une interface graphique utilisateur
WO2006127538A2 (fr) 2005-05-20 2006-11-30 Cadence Design Systems, Inc. Fabrication et conception tenant compte l'une de l'autre
US7395516B2 (en) 2005-05-20 2008-07-01 Cadence Design Systems, Inc. Manufacturing aware design and design aware manufacturing
US8156452B1 (en) * 2005-06-02 2012-04-10 Altera Corporation Method and apparatus for importing hardware description language into a system level design environment
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US20070054293A1 (en) * 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
JP4079962B2 (ja) * 2005-08-30 2008-04-23 株式会社東芝 電気掃除機
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US7496869B1 (en) 2005-10-04 2009-02-24 Xilinx, Inc. Method and apparatus for implementing a program language description of a circuit design for an integrated circuit
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
JP4528728B2 (ja) * 2006-01-31 2010-08-18 株式会社東芝 デジタル回路の自動設計装置、自動設計方法、および自動設計プログラム
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
EP1979079A4 (fr) 2006-02-03 2012-11-28 Integenx Inc Dispositifs microfluidiques
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US7380232B1 (en) 2006-03-10 2008-05-27 Xilinx, Inc. Method and apparatus for designing a system for implementation in a programmable logic device
US7761272B1 (en) 2006-03-10 2010-07-20 Xilinx, Inc. Method and apparatus for processing a dataflow description of a digital processing system
US8402409B1 (en) 2006-03-10 2013-03-19 Xilinx, Inc. Method and apparatus for supporting run-time reconfiguration in a programmable logic integrated circuit
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
DE102006016324A1 (de) * 2006-04-06 2007-10-25 Wacker Chemie Ag Vorrichtung und Verfahren zum flexiblen Klassieren von polykristallinen Silicium-Bruchstücken
US8828661B2 (en) * 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8302042B2 (en) * 2006-07-24 2012-10-30 Oasys Design Systems Generating a convergent circuit design from a functional description using entities having access to the functional description and to physical design information
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
WO2008047650A1 (fr) * 2006-10-11 2008-04-24 Zuken Inc. Procédé de traitement, dispositif de traitement, programme et support de stockage lisible par ordinateur
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2008067552A2 (fr) * 2006-11-30 2008-06-05 Fluidigm Corporation Procédé et appareil pour l'analyse d'échantillons biologiques
JP2008177224A (ja) * 2007-01-16 2008-07-31 Nuflare Technology Inc 図形データの検証方法
EP2125219B1 (fr) 2007-01-19 2016-08-10 Fluidigm Corporation Dispositifs microfluidiques d'efficacité élevée et de précision élevée et procédés
CN101715483A (zh) 2007-02-05 2010-05-26 微芯片生物工艺学股份有限公司 微流体和纳米流体装置、系统和应用
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
WO2009015296A1 (fr) 2007-07-24 2009-01-29 The Regents Of The University Of California Générateur de gouttelettes microfabriqué
CN101821619B (zh) 2007-09-07 2015-02-11 弗卢丁公司 拷贝数变化确定、方法和系统
WO2009108260A2 (fr) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Système de préparation d’échantillon universel et utilisation dans un système d’analyse intégré
WO2009100449A1 (fr) 2008-02-08 2009-08-13 Fluidigm Corporation Procédés de dosage de réseau dynamique
EP2280905B1 (fr) 2008-04-11 2016-07-06 Fluidigm Corporation Systèmes et procédés microfluidiques à plusieurs niveaux
WO2009134786A2 (fr) * 2008-04-30 2009-11-05 The Board Of Regents Of The University Of Texas System Procédé de contrôle de qualité et dispositifs à microcanaux ou à nanocanaux
US8622987B2 (en) * 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
US9579830B2 (en) 2008-07-25 2017-02-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
WO2010017210A1 (fr) 2008-08-07 2010-02-11 Fluidigm Corporation Systèmes microfluidique de mélange et de réaction pour un tamisage à efficacité élevée
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US8898618B2 (en) * 2009-03-26 2014-11-25 Altera Corporation Interactive simplification of schematic diagram of integrated circuit design
US8732651B1 (en) * 2009-04-13 2014-05-20 Cadence Design Systems, Inc. Logical design flow with structural compatability verification
US8712751B2 (en) * 2009-05-08 2014-04-29 Qualcomm Incorporated System and method of verification of analog circuits
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
BRPI1010169A2 (pt) 2009-06-05 2016-03-29 Integenx Inc sistema que se ajusta dentro de um invólucro de não mais que 10 pés3, cartucho, artigo em forma legível por computador, método, sistema configurado para realizar um método, sistema óptico, instrumento e dispositivo.
US8551787B2 (en) * 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
WO2011066588A1 (fr) 2009-11-30 2011-06-03 Fluidigm Corporation Régénération d'un dispositif microfluidique
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8543958B2 (en) * 2009-12-11 2013-09-24 Synopsys, Inc. Optical proximity correction aware integrated circuit design optimization
WO2011090556A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Procédés pour déterminer une fraction d'acide nucléique fœtal dans des échantillons maternels
EP4074838A1 (fr) 2010-01-19 2022-10-19 Verinata Health, Inc. Nouveau protocole de préparation de bibliothèques de séquençage
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
EP2606242A4 (fr) 2010-08-20 2016-07-20 Integenx Inc Dispositifs microfluidiques pourvus de soupapes à diaphragme mécaniquement scellées
WO2012024658A2 (fr) 2010-08-20 2012-02-23 IntegenX, Inc. Système d'analyse intégrée
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
US8775998B2 (en) * 2010-12-09 2014-07-08 Panasonic Corporation Support device of three-dimensional integrated circuit and method thereof
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
WO2012154876A1 (fr) 2011-05-09 2012-11-15 Fluidigm Corporation Détection d'acide nucléique à l'aide d'une sonde
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US8769456B1 (en) * 2011-10-26 2014-07-01 Cadence Design Systems, Inc. Methods, systems, and articles for implementing extraction and electrical analysis-driven module creation
WO2013112755A1 (fr) 2012-01-24 2013-08-01 The Trustees Of Columbia University In The City Of New York Dispositifs, procédés et systèmes d'analyse optimisée sur site
US8942963B1 (en) * 2012-05-07 2015-01-27 Msc.Software Corporation Directed design updates in engineering methods for systems
US9026962B2 (en) * 2012-05-30 2015-05-05 Gumstix, Inc. Integrated electronic design automation system
US9060671B2 (en) 2012-08-17 2015-06-23 The Nielsen Company (Us), Llc Systems and methods to gather and analyze electroencephalographic data
US9449196B1 (en) 2013-04-22 2016-09-20 Jasper Design Automation, Inc. Security data path verification
WO2015009553A1 (fr) 2013-07-17 2015-01-22 Texas Tech University System Système et procédé de simulation et de conception de systèmes microfluidiques à gouttelettes discrètes
GB2519545A (en) * 2013-10-24 2015-04-29 Ibm Determining a quality parameter for a verification environment
US9141741B1 (en) * 2013-10-29 2015-09-22 Cadence Design Systems, Inc. Methods, systems, and articles of manufacture for implementing mixed-signal electronic circuit designs with power data in standardized power formats
WO2015073999A1 (fr) 2013-11-18 2015-05-21 Integenx Inc. Cartouches et instruments pour l'analyse d'échantillons
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
WO2016025698A1 (fr) 2014-08-13 2016-02-18 The Trustees Of Columbia University In The City Of New York Procédés, systèmes et dispositifs de diagnostic
CN105468797B (zh) * 2014-08-22 2019-10-22 深圳市中兴微电子技术有限公司 一种信息处理方法及装置
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
CN105653744A (zh) * 2014-11-13 2016-06-08 中芯国际集成电路制造(上海)有限公司 版图布局的设计方法及装置
US20170046466A1 (en) * 2015-08-10 2017-02-16 International Business Machines Corporation Logic structure aware circuit routing
US10914669B2 (en) 2015-10-22 2021-02-09 Georgia Tech Research Corporation Electronic sensors for multiplexed detection of particles on microfluidic chips and uses thereof
US9892225B2 (en) 2016-04-01 2018-02-13 International Business Machines Corporation Method for optimizing the design of micro-fluidic devices
US10360336B2 (en) * 2016-10-27 2019-07-23 The Regents Of The University Of California Microfluidics planar placement and routing algorithm
RU2648444C1 (ru) * 2016-12-30 2018-03-26 Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") Демпфирующий элемент микрофлюидного чипа и микрофлюидный чип
US10296703B1 (en) * 2017-09-20 2019-05-21 Cadence Design Systems, Inc. System and method for visualization in an electronic circuit design
US10839319B2 (en) 2017-09-27 2020-11-17 Allstate Insurance Company Data processing system with machine learning engine to provide output generating functions
US20190095815A1 (en) * 2017-09-27 2019-03-28 Allstate Insurance Company Data Processing System with Machine Learning Engine to Provide Output Generating Functions
US11537935B2 (en) 2017-09-27 2022-12-27 Allstate Insurance Company Data processing system with machine learning engine to provide output generating functions
US10769346B1 (en) * 2017-12-28 2020-09-08 Cadence Design Systems, Inc. Method, system, and computer program product for rearrangement of objects within an electronic design
CN110142069B (zh) * 2019-04-09 2021-07-09 广东工业大学 基于微纳工艺的微流道芯片加工方法
US11366943B2 (en) * 2019-06-18 2022-06-21 International Business Machines Corporation Platform for design and prototyping of micro paper based devices
CN116422267B (zh) * 2023-03-29 2023-09-12 浙江长鸿生物材料有限公司 一种br橡胶生产用溶解反应釜

Family Cites Families (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656508A (en) 1949-08-27 1953-10-20 Wallace H Coulter Means for counting particles suspended in a fluid
US3581077A (en) * 1968-07-01 1971-05-25 Southern Gas Ass Electrical analog model for fluid flow transmission system
US3570515A (en) 1969-06-19 1971-03-16 Foxboro Co Aminar stream cross-flow fluid diffusion logic gate
NL7102074A (fr) 1971-02-17 1972-08-21
US3839176A (en) 1971-03-08 1974-10-01 North American Rockwell Method and apparatus for removing contaminants from liquids
US3984307A (en) 1973-03-05 1976-10-05 Bio/Physics Systems, Inc. Combined particle sorter and segregation indicator
US3915652A (en) 1973-08-16 1975-10-28 Samuel Natelson Means for transferring a liquid in a capillary open at both ends to an analyzing system
FR2287606A1 (fr) 1974-10-08 1976-05-07 Pegourie Jean Pierre Circuits logiques pneumatiques et leurs circuits integres
JPS5941169B2 (ja) 1975-12-25 1984-10-05 シチズン時計株式会社 エラストマ−ヒヨウジソウチ
US4153855A (en) 1977-12-16 1979-05-08 The United States Of America As Represented By The Secretary Of The Army Method of making a plate having a pattern of microchannels
US4245673A (en) 1978-03-01 1981-01-20 La Telemechanique Electrique Pneumatic logic circuit
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4434704A (en) 1980-04-14 1984-03-06 Halliburton Company Hydraulic digital stepper actuator
GB2097692B (en) 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4399219A (en) 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
US4575681A (en) 1982-11-12 1986-03-11 Teleco Oilfield Services Inc. Insulating and electrode structure for a drill string
US4662710A (en) 1982-12-03 1987-05-05 Amp Incorporated Method and apparatus for breaking an optical fiber
US4585209A (en) 1983-10-27 1986-04-29 Harry E. Aine Miniature valve and method of making same
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
GB8408529D0 (en) 1984-04-03 1984-05-16 Health Lab Service Board Concentration of biological particles
JPH07104855B2 (ja) * 1985-03-28 1995-11-13 インターナショナル・ビジネス・マシーンズ・コーポレーション 数値シミュレーション装置
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4675300A (en) 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
FI891524L (fi) 1987-07-31 1989-03-30 Gen Probe Inc Bestaemning av polynukleotider, varvid anvaends oligonukleotider foer att hindra icke oenskvaerda sidoreaktioner.
US4990216A (en) 1987-10-27 1991-02-05 Fujitsu Limited Process and apparatus for preparation of single crystal of biopolymer
US4936465A (en) 1987-12-07 1990-06-26 Zoeld Tibor Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system
US5354695A (en) 1992-04-08 1994-10-11 Leedy Glenn J Membrane dielectric isolation IC fabrication
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US4965743A (en) 1988-07-14 1990-10-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Discrete event simulation tool for analysis of qualitative models of continuous processing system
US4898582A (en) 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
US5032381A (en) 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US4992312A (en) 1989-03-13 1991-02-12 Dow Corning Wright Corporation Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
CH679555A5 (fr) 1989-04-11 1992-03-13 Westonbridge Int Ltd
JPH04501449A (ja) 1989-06-14 1992-03-12 ウエストンブリッジ インターナショナル リミティド マイクロポンプ
US5100627A (en) 1989-11-30 1992-03-31 The Regents Of The University Of California Chamber for the optical manipulation of microscopic particles
US5171132A (en) 1989-12-27 1992-12-15 Seiko Epson Corporation Two-valve thin plate micropump
JPH03239770A (ja) 1990-02-16 1991-10-25 Kansai Paint Co Ltd カチオン電着塗料用樹脂組成物
DE4006152A1 (de) 1990-02-27 1991-08-29 Fraunhofer Ges Forschung Mikrominiaturisierte pumpe
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5096388A (en) 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
US5867399A (en) * 1990-04-06 1999-02-02 Lsi Logic Corporation System and method for creating and validating structural description of electronic system from higher-level and behavior-oriented description
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5259737A (en) 1990-07-02 1993-11-09 Seiko Epson Corporation Micropump with valve structure
US5315530A (en) * 1990-09-10 1994-05-24 Rockwell International Corporation Real-time control of complex fluid systems using generic fluid transfer model
WO1992019960A1 (fr) 1991-05-09 1992-11-12 Nanophore, Inc. Procedes de separation electrophoretique d'acides nucleiques et d'autres macromolecules lineaires dans des milieux constitues par des gels a diametres de pores restreints
DE4119955C2 (de) 1991-06-18 2000-05-31 Danfoss As Miniatur-Betätigungselement
US5164558A (en) 1991-07-05 1992-11-17 Massachusetts Institute Of Technology Micromachined threshold pressure switch and method of manufacture
JP3328300B2 (ja) 1991-07-18 2002-09-24 アイシン精機株式会社 流体制御装置
US5307186A (en) 1991-08-09 1994-04-26 Sharp Kabushiki Kaisha Liquid crystal light valve having capability of providing high-contrast image
DE4127405C2 (de) 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
DE4143343C2 (de) 1991-09-11 1994-09-22 Fraunhofer Ges Forschung Mikrominiaturisierte, elektrostatisch betriebene Mikromembranpumpe
US5265327A (en) 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US6569382B1 (en) * 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US5558998A (en) 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
JP2740705B2 (ja) 1992-04-08 1998-04-15 本田技研工業株式会社 流体式トルクコンバータの特性シミュレーション方法および装置
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
DE4220077A1 (de) 1992-06-19 1993-12-23 Bosch Gmbh Robert Mikropumpe
US5629147A (en) 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5364742A (en) 1992-09-21 1994-11-15 International Business Machines Corporation Micro-miniature structures and method of fabrication thereof
DE69327389T2 (de) * 1992-10-29 2000-06-15 Altera Corp., San Jose Verfahren zum Prüfen von Entwürfen für programmierbare Logikschaltungen
US5477474A (en) 1992-10-29 1995-12-19 Altera Corporation Computer logic simulation with dynamic modeling
JP2812629B2 (ja) 1992-11-25 1998-10-22 宇宙開発事業団 結晶成長セル
US5290240A (en) 1993-02-03 1994-03-01 Pharmetrix Corporation Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
US5681024A (en) 1993-05-21 1997-10-28 Fraunhofer-Gesellschaft zur Forderung der angerwanden Forschung e.V. Microvalve
SE501713C2 (sv) 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler
US5642015A (en) 1993-07-14 1997-06-24 The University Of British Columbia Elastomeric micro electro mechanical systems
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
EP0722541B1 (fr) 1993-10-04 1998-12-30 Research International, Inc. Commutateurs de debit micro-usines
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
CH689836A5 (fr) 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropompe.
EP0670489A3 (fr) 1994-03-03 1996-03-06 Ciba Geigy Ag Appareil et procédé pour la séparation de substances fluides.
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5587081A (en) 1994-04-26 1996-12-24 Jet-Tech, Inc. Thermophilic aerobic waste treatment process
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE4433894A1 (de) 1994-09-22 1996-03-28 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Ansteuerung einer Mikropumpe
US5496009A (en) 1994-10-07 1996-03-05 Bayer Corporation Valve
DE69531430T2 (de) 1994-10-07 2004-07-01 Bayer Corp. Entlastungsventil
DE4437274C2 (de) 1994-10-18 1998-11-05 Inst Chemo Biosensorik Analytselektiver Sensor
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
DE4438785C2 (de) 1994-10-24 1996-11-07 Wita Gmbh Wittmann Inst Of Tec Mikrochemische Reaktions- und Analyseeinheit
US5788468A (en) 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5665070A (en) 1995-01-19 1997-09-09 I-Flow Corporation Infusion pump with magnetic bag compression
JP3094880B2 (ja) 1995-03-01 2000-10-03 住友金属工業株式会社 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5876187A (en) 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US5608519A (en) 1995-03-20 1997-03-04 Gourley; Paul L. Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells
US5661222A (en) 1995-04-13 1997-08-26 Dentsply Research & Development Corp. Polyvinylsiloxane impression material
US5757482A (en) 1995-04-20 1998-05-26 Perseptive Biosystems, Inc. Module for optical detection in microscale fluidic analyses
US5867400A (en) * 1995-05-17 1999-02-02 International Business Machines Corporation Application specific processor and design method for same
DE19520298A1 (de) 1995-06-02 1996-12-05 Bayer Ag Sortiervorrichtung für biologische Zellen oder Viren
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5812394A (en) 1995-07-21 1998-09-22 Control Systems International Object-oriented computer program, system, and method for developing control schemes for facilities
CA2183478C (fr) 1995-08-17 2004-02-24 Stephen A. Carter Systeme numerique de gazometrie a l'aide de solenoides bistables et tristables
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5726751A (en) 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
KR100207410B1 (ko) 1995-12-19 1999-07-15 전주범 광로 조절 장치의 제조방법
US5802349A (en) * 1996-01-22 1998-09-01 Motorola, Inc. Method for generating an optimized integrated circuit cell library
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5660370A (en) 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
EP0909385B1 (fr) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Procédé de transport d'échantillons de fluides par un canal microfluidique
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
CA2259395C (fr) 1996-07-15 2002-03-05 Sumitomo Metal Industries, Ltd. Equipement de croissance de cristaux et procede pour la croissance de cristaux utilisant cet equipement
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
US5738799A (en) 1996-09-12 1998-04-14 Xerox Corporation Method and materials for fabricating an ink-jet printhead
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5858187A (en) 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US6056428A (en) 1996-11-12 2000-05-02 Invention Machine Corporation Computer based system for imaging and analyzing an engineering object system and indicating values of specific design changes
EP0946749A1 (fr) * 1996-11-20 1999-10-06 The Regents Of The University Of Michigan Dispositifs microfabriques et procedes d'amplification isotherme d'acides nucleiques
US5839722A (en) 1996-11-26 1998-11-24 Xerox Corporation Paper handling system having embedded control structures
US5971355A (en) 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
AU6135298A (en) 1997-01-27 1998-08-26 California Institute Of Technology Mems electrospray nozzle for mass spectroscopy
US6376971B1 (en) 1997-02-07 2002-04-23 Sri International Electroactive polymer electrodes
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
US6116766A (en) * 1997-04-15 2000-09-12 Maseeh; Fariborz Fabrication based computer aided design system using virtual fabrication techniques
KR100351531B1 (ko) * 1997-04-25 2002-09-11 캘리퍼 테크놀로지스 코포레이션 기하형상이 개선된 채널을 채용하는 미소 유체 장치
AU734957B2 (en) 1997-05-16 2001-06-28 Alberta Research Council Inc. Microfluidic system and methods of use
US6057864A (en) * 1997-06-03 2000-05-02 Eastman Kodak Company Image producing apparatus for uniform microfluidic printing
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US5882465A (en) * 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
WO1999000655A2 (fr) 1997-06-27 1999-01-07 Immunetics, Inc. Appareil et procede d'essai de liaison rapide en ecoulement continu
AU8492998A (en) 1997-07-16 1999-02-10 Diversified Scientific, Inc. Method for acquiring, storing and analyzing crystal images
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5965410A (en) * 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US7214298B2 (en) 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6103537A (en) 1997-10-02 2000-08-15 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US5836750A (en) 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6345502B1 (en) 1997-11-12 2002-02-12 California Institute Of Technology Micromachined parylene membrane valve and pump
US6089534A (en) 1998-01-08 2000-07-18 Xerox Corporation Fast variable flow microelectromechanical valves
ATE364148T1 (de) 1998-01-20 2007-06-15 Invensys Sys Inc Elektromagnet- vorrichtung mit zwei von drei elektromagneten die immer betätigt sind
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
US5997961A (en) 1998-03-06 1999-12-07 Battelle Memorial Institute Method of bonding functional surface materials to substrates and applications in microtechnology and antifouling
WO1999052633A1 (fr) 1998-04-14 1999-10-21 Ivd Systems Cartouche d'analyse a un seul orifice d'entree
WO1999061888A2 (fr) 1998-05-22 1999-12-02 California Institute Of Technology Trieur de cellules microfabrique
US6246330B1 (en) 1998-05-29 2001-06-12 Wyn Y. Nielsen Elimination-absorber monitoring system
WO2000000678A1 (fr) 1998-06-26 2000-01-06 University Of Washington Milieux de cristallisation
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
CN100525876C (zh) 1998-09-17 2009-08-12 阿德文生物系统公司 产生液体电喷射的方法
US6605472B1 (en) 1998-10-09 2003-08-12 The Governors Of The University Of Alberta Microfluidic devices connected to glass capillaries with minimal dead volume
US6637463B1 (en) * 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
RU2143343C1 (ru) 1998-11-03 1999-12-27 Самсунг Электроникс Ко., Лтд. Микроинжектор и способ изготовления микроинжектора
US6541539B1 (en) 1998-11-04 2003-04-01 President And Fellows Of Harvard College Hierarchically ordered porous oxides
WO2000030167A1 (fr) 1998-11-19 2000-05-25 California Institute Of Technology Buse d'electronebulisation a base de polymere pour spectrometrie de masse
US6632655B1 (en) * 1999-02-23 2003-10-14 Caliper Technologies Corp. Manipulation of microparticles in microfluidic systems
AU3508600A (en) 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6500323B1 (en) * 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
DE60034033T2 (de) 1999-04-06 2007-12-06 University of Alabama, Birmingham Research Foundation, Birmingham Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung
US6520936B1 (en) 1999-06-08 2003-02-18 Medtronic Minimed, Inc. Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6664104B2 (en) 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
EP1065378B1 (fr) 1999-06-28 2002-04-03 California Institute of Technology Systemes de micropompes et microsoupapes elastomeriques
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7052545B2 (en) 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US6533914B1 (en) 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
DE19933614C1 (de) 1999-07-17 2000-11-30 Moeller Gmbh Kontaktsystem mit einem zweiarmigen Kontaktarm
WO2001006575A1 (fr) 1999-07-20 2001-01-25 Sri International Polymeres electroactifs ameliores
KR100677860B1 (ko) 1999-07-23 2007-02-05 보드 오브 트러스티스 오브 유니버스티 오브 일리노이즈 미세하게 제조되는 장치 및 그의 제조방법
US6977145B2 (en) 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
WO2001009595A2 (fr) 1999-08-02 2001-02-08 Emerald Biostructures, Inc. Procede et systeme de creation d'une base de donnees de resultats de cristallisation
CA2391842C (fr) * 1999-09-24 2005-08-16 California Institute Of Technology Micro-clapet de non-retour normalement ferme place dans le canal
US6606735B1 (en) * 1999-10-14 2003-08-12 Synopsys, Inc. Method and system for using error and filter layers in each DRC rule
US6898561B1 (en) * 1999-12-21 2005-05-24 Integrated Device Technology, Inc. Methods, apparatus and computer program products for modeling integrated circuit devices having reduced linewidths
WO2001053794A1 (fr) 2000-01-18 2001-07-26 Northeastern University Chargement d'echantillons en parallele et dispositif d'injection utilises pour des dispositifs a microfluides a plusieurs canaux
US6866785B2 (en) 2001-08-13 2005-03-15 The Board Of Trustees Of The Leland Stanford Junior University Photopolymerized sol-gel column and associated methods
US6530065B1 (en) * 2000-03-14 2003-03-04 Transim Technology Corporation Client-server simulator, such as an electrical circuit simulator provided by a web server over the internet
US6541071B1 (en) 2000-03-23 2003-04-01 Corning Incorporated Method for fabricating supported bilayer-lipid membranes
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
EP1285106A2 (fr) 2000-03-31 2003-02-26 Micronics, Inc. Cristallisation de proteines dans des structures microfluidiques
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6885982B2 (en) * 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
WO2002000343A2 (fr) * 2000-06-27 2002-01-03 Fluidigm Corporation Procede et systeme d'automatisation de conception de systemes microfluidiques
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
JP3542550B2 (ja) 2000-07-19 2004-07-14 本田技研工業株式会社 燃料電池用シールの成形方法
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
US6787339B1 (en) 2000-10-02 2004-09-07 Motorola, Inc. Microfluidic devices having embedded metal conductors and methods of fabricating said devices
EP1322936A2 (fr) 2000-10-03 2003-07-02 California Institute Of Technology Dispositifs microfluidiques et procedes d'utilisation
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
EP1336097A4 (fr) 2000-10-13 2006-02-01 Fluidigm Corp Systeme d'injection d'echantillons utilisant un dispositif microfluidique, pour dispositifs d'analyse
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
EP1345698A4 (fr) 2000-11-16 2006-05-17 Fluidigm Corp Dispositifs microfluidiques permettant l'introduction et la liberation de liquides a partir de systemes microfluidiques
US6736978B1 (en) 2000-12-13 2004-05-18 Iowa State University Research Foundation, Inc. Method and apparatus for magnetoresistive monitoring of analytes in flow streams
CA2442914A1 (fr) 2001-04-06 2002-10-17 California Institute Of Technology Criblage a haut rendement de la cristallisation de materiaux
WO2002081729A2 (fr) 2001-04-06 2002-10-17 California Institute Of Technology Amplification d'acide nucleique au moyen de dispositifs microfluidiques
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US6677131B2 (en) 2001-05-14 2004-01-13 Corning Incorporated Well frame including connectors for biological fluids
US20030049659A1 (en) 2001-05-29 2003-03-13 Lapidus Stanley N. Devices and methods for isolating samples into subsamples for analysis
US6847153B1 (en) 2001-06-13 2005-01-25 The United States Of America As Represented By The Secretary Of The Navy Polyurethane electrostriction
US6444318B1 (en) 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
WO2003031066A1 (fr) 2001-10-11 2003-04-17 California Institute Of Technology Dispositifs utilisant du gel auto-assemble et procede de fabrication associe
US6627076B2 (en) 2001-10-19 2003-09-30 Sandia National Laboratories Compact microchannel system
US20030175947A1 (en) 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US6893613B2 (en) 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
US6662818B2 (en) 2002-02-01 2003-12-16 Perseptive Biosystems, Inc. Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits
US6581441B1 (en) 2002-02-01 2003-06-24 Perseptive Biosystems, Inc. Capillary column chromatography process and system
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7186383B2 (en) 2002-09-27 2007-03-06 Ast Management Inc. Miniaturized fluid delivery and analysis system
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
US20040141887A1 (en) 2002-11-08 2004-07-22 Irm, Llc Apparatus and methods to process substrate surface features
KR101216828B1 (ko) 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7131105B2 (en) * 2003-09-19 2006-10-31 Coventor, Inc. System and method for automatic mesh generation from a system-level MEMS design
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat

Also Published As

Publication number Publication date
WO2002000343A2 (fr) 2002-01-03
US20020108096A1 (en) 2002-08-08
WO2002000343A3 (fr) 2002-06-06
US7526741B2 (en) 2009-04-28
US20050065735A1 (en) 2005-03-24
US20020183996A1 (en) 2002-12-05
US6829753B2 (en) 2004-12-07
US20060036416A1 (en) 2006-02-16
US7062418B2 (en) 2006-06-13

Similar Documents

Publication Publication Date Title
AU2001273057A1 (en) A microfluidic design automation method and system
AU2001270969A1 (en) A method and system for sharing knowledge
AU2001248391A1 (en) A method and a system for providing interactive question-based applications
AU2001243371A1 (en) System and method for a command structure representation
AU2001272500A1 (en) Micromachined fluidic device and method for making same
WO2002007460A8 (fr) Systeme et procede d'association de contexte
AU2002335924A1 (en) A system and method for fitting clothing
AU2002236031A1 (en) A prototype production system and method
AU2001282786A1 (en) A sample preparing arrangement and a method
AU2001294922A1 (en) Automated bioculture and bioculture experiments system
AU2002343467A1 (en) A method for providing system integrity and legacy environment emulation
AU2001238379A1 (en) A system and method for remotely configuring testing laboratories
AU2001240525A1 (en) Method for covering a microfluidic assembly
AU4094801A (en) A media processing system and method
AU2001289082A1 (en) Method and system for a lumped-distributed balun
AU2001285629A1 (en) Desulphurization reagent control method and system
WO2002023370A8 (fr) Procede et systeme d'optimisation
AU2000251458A1 (en) A building construction system and method
AU2001239863A1 (en) System and method for implementing a project facility
AU2000240749A1 (en) System and method for the automation of expense reports
AU2001253356A1 (en) Method and system for configuring remotely located applications
AU2001261008A1 (en) A system and method for communicating between distant regions
AU2002212084A1 (en) Method for constructing a component and wiper system component
AU2001275436A1 (en) A ph sensor system and method for using same
AU2001213129A1 (en) A messaging method and system