AU2001271567A1 - Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders - Google Patents
Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disordersInfo
- Publication number
- AU2001271567A1 AU2001271567A1 AU2001271567A AU7156701A AU2001271567A1 AU 2001271567 A1 AU2001271567 A1 AU 2001271567A1 AU 2001271567 A AU2001271567 A AU 2001271567A AU 7156701 A AU7156701 A AU 7156701A AU 2001271567 A1 AU2001271567 A1 AU 2001271567A1
- Authority
- AU
- Australia
- Prior art keywords
- geldanamycin
- prophylaxis
- treatment
- related compounds
- fibrogenic disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003352 fibrogenic effect Effects 0.000 title 1
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21495000P | 2000-06-29 | 2000-06-29 | |
| US60214950 | 2000-06-29 | ||
| PCT/US2001/020578 WO2002002123A1 (en) | 2000-06-29 | 2001-06-28 | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001271567A1 true AU2001271567A1 (en) | 2002-01-14 |
Family
ID=22801040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001271567A Abandoned AU2001271567A1 (en) | 2000-06-29 | 2001-06-28 | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US6887853B2 (en) |
| AU (1) | AU2001271567A1 (en) |
| WO (1) | WO2002002123A1 (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003037860A2 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| ATE433961T1 (en) | 2002-02-08 | 2009-07-15 | Conforma Therapeutics Corp | ANSAMYCINS WITH IMPROVED PHARMACOLOGICAL AND BIOLOGICAL PROPERTIES |
| EA010160B1 (en) | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Novel heterocyclic compounds as hsp90-inhibitors |
| JP2007512369A (en) * | 2003-11-26 | 2007-05-17 | エンテロス・インコーポレーテッド | Treatment of rheumatoid arthritis with hypoxia-inducible factor 1α antagonist |
| US7282493B2 (en) | 2003-12-23 | 2007-10-16 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| DE102004049078A1 (en) | 2004-10-08 | 2006-04-13 | Merck Patent Gmbh | phenylpyrazoles |
| EP1817295B1 (en) * | 2004-11-18 | 2012-11-07 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| DE102005009440A1 (en) | 2005-03-02 | 2006-09-07 | Merck Patent Gmbh | thienopyridine derivatives |
| KR20080004550A (en) | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Alkynyl pyrrolopyrimidines and related analogs as HPSPO-inhibitors |
| CA2618628C (en) | 2005-08-18 | 2014-11-18 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| GB0600168D0 (en) * | 2006-01-05 | 2006-02-15 | Neutec Pharma Plc | A therapeutic composition |
| WO2007139960A2 (en) * | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Compounds that modulate hsp90 activity and methods for identifying same |
| AR061185A1 (en) | 2006-05-26 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | HETEROCICLICAL COMPOUNDS AS INHIBITORS OF HSP90. PHARMACEUTICAL COMPOSITIONS. |
| US8067412B2 (en) | 2006-08-11 | 2011-11-29 | Universite De Strasbourg | Macrocyclic compounds useful as inhibitors of kinases and HSP90 |
| WO2008057246A2 (en) * | 2006-10-26 | 2008-05-15 | Synta Pharmaceuticals Corp. | Method for treating inflammatory disorders |
| DE102007002715A1 (en) | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | triazole |
| CN101675059A (en) | 2007-03-01 | 2010-03-17 | 中外制药株式会社 | Macrocyclic compound |
| DE102007028521A1 (en) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
| DE102007032739A1 (en) | 2007-07-13 | 2009-01-15 | Merck Patent Gmbh | Chinazolinamidderivate |
| DE102007041116A1 (en) | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | 1,3-dihydro-isoindole derivatives |
| WO2009062135A1 (en) * | 2007-11-09 | 2009-05-14 | The Ohio State University Research Foundation | Hsp90 inhibitors of protein-protein interaction hsp90 chaperone complexes and therapeutic uses thereof |
| US9051302B2 (en) | 2008-01-15 | 2015-06-09 | Universite De Strasbourg | Synthesis of resorcylic acid lactones useful as therapeutic agents |
| DE102008061214A1 (en) | 2008-12-09 | 2010-06-10 | Merck Patent Gmbh | Chinazolinamidderivate |
| DE102009054302A1 (en) | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | quinazoline derivatives |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| DE102010046837A1 (en) | 2010-09-29 | 2012-03-29 | Merck Patent Gmbh | Phenylchinazolinderivate |
| RU2013122898A (en) | 2010-10-22 | 2014-11-27 | Университы До Страсбур | Pohoxime conjugates applicable for the treatment of pathologies associated with the HSP90, composition and method of treatment using them |
| CA2747509C (en) | 2011-05-12 | 2017-07-18 | Oncogenex Technologies Inc. | Treatment of pulmonary and pleural fibrosis using hsp27 inhibitors |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| CA2853799A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| WO2013074594A1 (en) | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| ES2863700T3 (en) * | 2016-03-22 | 2021-10-11 | Mayo Found Medical Education & Res | Using fatty acid synthase inhibitors to treat fibrosis |
| EP3576732A1 (en) | 2017-01-31 | 2019-12-11 | Medizinische Hochschule Hannover (MHH) | Natural compounds and fibrosis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US4673637A (en) * | 1984-04-23 | 1987-06-16 | Hyman Edward S | Method for detecting bacteria in urine and for treating rheumatoid arthritis, essential hypertension and other diseases associated with bacteriuria |
| CA2113229C (en) * | 1994-01-11 | 1999-04-20 | Mark Pines | Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof |
| EP0828418A4 (en) * | 1995-05-02 | 2000-03-29 | Univ California | INDUCTION OF THERMOTOLERANCE USING ANSAMYCINS BENZOQUINONOIDES |
| US6174875B1 (en) * | 1999-04-01 | 2001-01-16 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
-
2001
- 2001-06-28 WO PCT/US2001/020578 patent/WO2002002123A1/en not_active Ceased
- 2001-06-28 AU AU2001271567A patent/AU2001271567A1/en not_active Abandoned
- 2001-06-28 US US10/312,287 patent/US6887853B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040082498A1 (en) | 2004-04-29 |
| WO2002002123A1 (en) | 2002-01-10 |
| US6887853B2 (en) | 2005-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2001271567A1 (en) | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders | |
| AU2001247331A1 (en) | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | |
| AU2001261637A1 (en) | Apparatus for treatment of spinal disorders | |
| HUP0402629A3 (en) | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | |
| GB0007193D0 (en) | Treatment of movrmrnt disorders | |
| AU2001242450A1 (en) | Substances for the treatment of spinal muscular atrophy | |
| EP1392292A4 (en) | Pyranoindazoles and their use for the treatment of glaucoma | |
| IL151890A0 (en) | Hydroxyphenyl-piperidin 4-ylidene-methyl-benzamide derivatives for the treatment of pain | |
| IL155589A0 (en) | Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders | |
| ZA200208228B (en) | Use of il-18 inhibitors for the treatment and/or prevention of athesclerosis | |
| PL369850A1 (en) | Substituted indoles, method for production and use thereof for the inhibition of pain | |
| AU2001277534A1 (en) | Method for locating compounds which are suitable for the treatment and/or prophylaxis of obesity | |
| AU2001271887A1 (en) | Methods for diagnosis and treatment of psychiatric disorders | |
| AU2001256855A1 (en) | Preparation for the prevention and treatment of ocular disorders | |
| AU2002217866A1 (en) | Geldanamycin derivatives useful for the treatment of cancer | |
| AU2002220735A1 (en) | Substituted derivatives of aminofuran-2-yl-acetic acid and aminothien-2-yl-acetic acid and the use thereof for treating migraines and pain | |
| IL151765A0 (en) | Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain | |
| IL151891A0 (en) | Quinolinyl-piperidin 4-ylidene-methyl-benzamide derivatives for the treatment of pain | |
| AU2001275450A1 (en) | Bismuth compounds for the treatment and prevention of mucositis | |
| PL375564A1 (en) | Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma | |
| EP1455780A4 (en) | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma | |
| AU2003291368A1 (en) | Compounds for the treatment of tobacco dependence and withdrawal | |
| AU2001239301A1 (en) | Use of ectoin or ectoin derivatives for the prophylaxis and/or treatment of uv-induced immunosuppression | |
| AU2001273759A1 (en) | Essential oils and chemically related species for the treatment of increased bone resorption | |
| AU2000272704A1 (en) | Use of compounds for the treatment of obesity |