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AU2001270822A1 - Imidazolophthalazine derivatives as ligands for gabaa receptors - Google Patents

Imidazolophthalazine derivatives as ligands for gabaa receptors

Info

Publication number
AU2001270822A1
AU2001270822A1 AU2001270822A AU7082201A AU2001270822A1 AU 2001270822 A1 AU2001270822 A1 AU 2001270822A1 AU 2001270822 A AU2001270822 A AU 2001270822A AU 7082201 A AU7082201 A AU 7082201A AU 2001270822 A1 AU2001270822 A1 AU 2001270822A1
Authority
AU
Australia
Prior art keywords
imidazolophthalazine
ligands
derivatives
gabaa receptors
gabaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001270822A
Inventor
Richard Alexander Jelley
Tamara Ladduwahetty
Angus Murray Macleod
Andrew Madin
Francine Sternfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU2001270822A1 publication Critical patent/AU2001270822A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001270822A 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors Abandoned AU2001270822A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0017518 2000-07-17
GBGB0017518.2A GB0017518D0 (en) 2000-07-17 2000-07-17 Therapeutic agents
PCT/GB2001/003170 WO2002006285A1 (en) 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors

Publications (1)

Publication Number Publication Date
AU2001270822A1 true AU2001270822A1 (en) 2002-01-30

Family

ID=9895810

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001270822A Abandoned AU2001270822A1 (en) 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors

Country Status (5)

Country Link
US (1) US6949549B2 (en)
EP (1) EP1303516A1 (en)
AU (1) AU2001270822A1 (en)
GB (1) GB0017518D0 (en)
WO (1) WO2002006285A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
JP4561698B2 (en) * 2002-02-19 2010-10-13 小野薬品工業株式会社 Fused pyridazine derivative compound and drug containing the compound as an active ingredient
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
AU2015315167A1 (en) * 2014-09-10 2017-03-16 Epizyme, Inc. Isoxazole carboxamide compounds
CN107344939A (en) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 Imidazoles [2,1-a] phthalazine derivative, its preparation method, pharmaceutical composition and purposes
HU231223B1 (en) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. Bicyclic derivatives as gabaa a5 receptor modulators
CN120208880A (en) 2019-09-12 2025-06-27 米拉蒂医疗股份有限公司 MTA-synergistic PRMT5 inhibitor
WO2021191837A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators
TW202214574A (en) * 2020-06-08 2022-04-16 加拿大商愛彼特生物製藥公司 Substituted (phthalazin-1-ylmethyl)ureas, substituted n-(phthalazin-1-ylmethyl)amides, and analogues thereof
CN116903611A (en) * 2022-01-26 2023-10-20 上海优理惠生医药有限公司 A phthalazinone compound, its preparation method, its pharmaceutical composition and its application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6428294A (en) 1993-03-31 1994-10-24 Basf Aktiengesellschaft Imidazoloquinoxalinone derivatives as eaa antagonists
JP4216905B2 (en) 1996-07-25 2009-01-28 メルク シヤープ エンド ドーム リミテツド Substituted triazolopyridazine derivatives as ligands for GABA receptors
TW382169B (en) 1997-02-19 2000-02-11 Next Level Comm Video, data and telephony gateway
GB9801234D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
AU2001275014A1 (en) * 2000-05-30 2001-12-11 Neurogen Corporation Imidazoloisoquinolines

Also Published As

Publication number Publication date
EP1303516A1 (en) 2003-04-23
US6949549B2 (en) 2005-09-27
WO2002006285A1 (en) 2002-01-24
US20040147517A1 (en) 2004-07-29
GB0017518D0 (en) 2000-08-30

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