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AU2001268855A1 - Single-domain antigen-binding antibody fragments derived from llama antibodies - Google Patents

Single-domain antigen-binding antibody fragments derived from llama antibodies

Info

Publication number
AU2001268855A1
AU2001268855A1 AU2001268855A AU6885501A AU2001268855A1 AU 2001268855 A1 AU2001268855 A1 AU 2001268855A1 AU 2001268855 A AU2001268855 A AU 2001268855A AU 6885501 A AU6885501 A AU 6885501A AU 2001268855 A1 AU2001268855 A1 AU 2001268855A1
Authority
AU
Australia
Prior art keywords
antibody fragments
binding antibody
fragments derived
domain antigen
llama antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001268855A
Inventor
Ginette Dubuc
Saran Narang
Jasmid Tanha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of AU2001268855A1 publication Critical patent/AU2001268855A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2001268855A 2000-05-26 2001-05-25 Single-domain antigen-binding antibody fragments derived from llama antibodies Abandoned AU2001268855A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20723400P 2000-05-26 2000-05-26
US60/207,234 2000-05-26
PCT/CA2001/000763 WO2001090190A2 (en) 2000-05-26 2001-05-25 Single-domain antigen-binding antibody fragments derived from llama antibodies

Publications (1)

Publication Number Publication Date
AU2001268855A1 true AU2001268855A1 (en) 2001-12-03

Family

ID=22769713

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001268855A Abandoned AU2001268855A1 (en) 2000-05-26 2001-05-25 Single-domain antigen-binding antibody fragments derived from llama antibodies

Country Status (4)

Country Link
US (2) US20030190598A1 (en)
AU (1) AU2001268855A1 (en)
CA (1) CA2380443C (en)
WO (1) WO2001090190A2 (en)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4213586B2 (en) 2001-09-13 2009-01-21 株式会社抗体研究所 Camel antibody library production method
JP2005289809A (en) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) Mutant heavy chain antibody
CA2488441C (en) 2002-06-03 2015-01-27 Genentech, Inc. Synthetic antibody phage libraries
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US20050079574A1 (en) * 2003-01-16 2005-04-14 Genentech, Inc. Synthetic antibody phage libraries
US7329725B1 (en) * 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
CA2562133A1 (en) * 2004-03-19 2005-09-29 Zelos Therapeutics, Inc. Compositions and methods for detecting cyclic analogs of human parathyroid hormone (hpth)
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
ATE473446T1 (en) 2005-01-14 2010-07-15 Ablynx Nv METHODS AND TEST DEVICES FOR DIFFERENTIATING DIFFERENT FORMS OF DISEASES AND DISEASES CHARACTERIZED BY THROMBOCYTOPENIA AND/OR BY SPONTANEOUS INTERACTIONS BETWEEN THE VON WILLEBRAND FACTOR AND PLATES
JP5032458B2 (en) 2005-03-11 2012-09-26 シンジェンタ リミテッド Pest control
CN103254309B (en) 2005-05-18 2017-09-26 埃博灵克斯股份有限公司 For the improved nanometer body of tumor necrosis factor αTM
CN101213214B (en) 2005-05-20 2014-06-25 埃博灵克斯股份有限公司 Single domain VHH antibody against von Willebrand factor
DE102005023617A1 (en) 2005-05-21 2006-11-23 Aspre Ag Method for mixing colors in a display
US20100119445A1 (en) 2005-07-21 2010-05-13 N.V. Organon Plexin d1 as a target for tumor diagnosis and therapy
US8361462B2 (en) 2005-09-01 2013-01-29 National Research Council Of Canada Anti-apoptotic protein antibodies
EP2465870A1 (en) 2005-11-07 2012-06-20 Genentech, Inc. Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
US7704953B2 (en) * 2006-02-17 2010-04-27 Mdrna, Inc. Phage displayed cell binding peptides
EP3028716B1 (en) 2006-10-10 2020-09-16 Regenesance B.V. Complement inhibition for improved nerve regeneration
EP2514767A1 (en) 2006-12-19 2012-10-24 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
EP2115004A2 (en) 2006-12-19 2009-11-11 Ablynx N.V. Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
DK2308514T3 (en) 2007-03-23 2013-09-02 To Bbb Holding B V Conjugates for targeted drug transport through the blood-brain barrier
EP2008666A1 (en) 2007-06-29 2008-12-31 Institut Pasteur Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications
JP5240870B2 (en) 2007-07-03 2013-07-17 アブリンクス エン．ヴェー． Methods for providing improved immunoglobulin sequences
BRPI0815848A2 (en) * 2007-08-30 2017-06-06 The Burnet Inst compound, stable antibody-producing cell line, composition, methods for modulating an immune response in an individual and for treating and / or preventing disease, uses of a compound and / or composition and dendritic cells or precursors thereof, methods to enrich and detect dendritic cells or a subset or precursors thereof, polypeptide, vector polynucleotide, host cell, transgenic plant, transgenic non-human animal, extract, process for preparing a compound or polypeptide, enriched dendritic cell population and / or precursors expanded dendritic cell population and / or precursors thereof, methods for identifying a molecule that binds to a polypeptide and screening for a compound that binds to a polypeptide, use of a polypeptide, a polynucleotide, a vector , a host cell, a transgenic plant, an extract, a cell population and / or a composition. tion, method for producing a compound, and kit.
CN101970490A (en) 2007-11-27 2011-02-09 埃博灵克斯股份有限公司 Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
WO2009109572A2 (en) * 2008-03-03 2009-09-11 Ablynx Nv Monovalent phage display of single variable domains
CA2717015A1 (en) 2008-03-05 2009-09-11 Ablynx Nv Novel antigen binding dimer-complexes, methods of making and uses thereof
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
US9908943B2 (en) 2008-04-03 2018-03-06 Vib Vzw Single domain antibodies capable of modulating BACE activity
WO2009121948A2 (en) 2008-04-03 2009-10-08 Vib Vzw Single domain antibodies capable of modulating bace activity
WO2009124931A2 (en) * 2008-04-07 2009-10-15 Ablynx Nv Amino acid sequences directed against the notch pathways and uses thereof
WO2009127691A1 (en) 2008-04-17 2009-10-22 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
US9212226B2 (en) 2008-05-16 2015-12-15 Ablynx N.V. Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
DK2285408T3 (en) 2008-06-05 2019-02-04 Ablynx Nv AMINO ACID SEQUENCES AGAINST COATING PROTEINS IN A VIRUS AND POLYPEPTIDES INCLUDING THESE FOR TREATMENT OF VIRUSAL DISEASES
US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
CA2747644C (en) 2008-12-19 2023-01-24 Ablynx N.V. Method for generation of immunoglobulin sequences
WO2010085790A1 (en) * 2009-01-26 2010-07-29 Baylor College Of Medicine A single chain antibody for the detection of noroviruses
US10005830B2 (en) 2009-03-05 2018-06-26 Ablynx N.V. Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
DK2982690T3 (en) 2009-04-30 2021-04-12 Ablynx Nv METHOD OF PREPARING DOMAIN ANTIBODIES
HUE051430T2 (en) 2009-07-10 2021-03-01 Ablynx Nv Method for the production of variable domains
CA2772613C (en) 2009-09-03 2020-03-10 Schering Corporation Anti-gitr antibodies
PT2473528E (en) 2009-09-03 2015-03-04 Ablynx NV STABLE POLYETHYDE FORMULATIONS AND ITS USES
WO2011049449A1 (en) 2009-10-22 2011-04-28 University Of Twente Vhh for application in tissue repair, organ regeneration, organ replacement and tissue engineering
WO2011067160A1 (en) 2009-12-01 2011-06-09 Ablynx Nv Von willebrand factor specific binding agents and uses thereof
US8962807B2 (en) 2009-12-14 2015-02-24 Ablynx N.V. Single variable domain antibodies against OX40L, constructs and therapeutic use
WO2011083140A1 (en) 2010-01-08 2011-07-14 Ablynx Nv Immunoglobulin single variable domain directed against human cxcr4
WO2011095545A1 (en) 2010-02-05 2011-08-11 Ablynx Nv Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
HRP20191071T1 (en) 2010-02-11 2019-09-20 Ablynx N.V. PROCEDURES AND PREPARATIONS FOR AEROSOL PREPARATION
US9101674B2 (en) 2010-03-29 2015-08-11 Vib Vzw Targeting and in vivo imaging of tumor-associated macrophages
US9556273B2 (en) 2010-03-29 2017-01-31 Vib Vzw Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
US8877188B2 (en) 2010-05-04 2014-11-04 The Brigham And Women's Hospital, Inc. Detection and treatment of non-dermal fibrosis
EP2566967B1 (en) 2010-05-04 2016-07-06 The Brigham and Women's Hospital, Inc. Cadherin-11 antagonist for the treatment of fibrosis
SG185354A1 (en) 2010-05-20 2012-12-28 Ablynx Nv Biological materials related to her3
WO2011161263A1 (en) 2010-06-25 2011-12-29 Ablynx Nv Pharmaceutical compositions for cutaneous administration
GB201014715D0 (en) 2010-09-06 2010-10-20 Vib Vzw Nanobodies stabilizing functional conformational states of GPCRS
HUE036251T2 (en) 2010-08-26 2018-06-28 Agrosavfe N V Chitinous polysaccharide antigen binding proteins
EP3279214B1 (en) 2010-10-29 2024-10-09 Ablynx NV Method for the production of immunoglobulin single variable domains
EP2691415B1 (en) 2011-03-28 2018-07-11 Ablynx N.V. Method for producing solid formulations comprising immunoglobulin single variable domains
UA117218C2 (en) 2011-05-05 2018-07-10 Мерк Патент Гмбх POLYPEPTIDE AGAINST IL-17A, IL-17F AND / OR IL17-A / F
EP3590950A1 (en) 2011-05-09 2020-01-08 Ablynx NV Method for the production of immunoglobulin single varible domains
RU2661677C2 (en) 2011-05-27 2018-07-18 Аблинкс Нв Inhibition of bone resorption with rank-l binding peptides
ES2662372T3 (en) 2011-06-21 2018-04-06 Vib Vzw Binding domains directed against GPCR complexes: G protein and uses derived therefrom
JP2014525736A (en) 2011-06-23 2014-10-02 アブリンクス エン．ヴェー． Immunoglobulin single variable domain for IgE
WO2013041722A1 (en) 2011-09-23 2013-03-28 Ablynx Nv Prolonged inhibition of interleukin-6 mediated signaling
US10112988B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
US10112987B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
EP2617732A1 (en) 2012-01-19 2013-07-24 Vib Vzw Tools and methods for expression of membrane proteins
CA2874309C (en) 2012-05-24 2021-06-15 Vib Vzw Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
EP3590578A1 (en) 2013-02-05 2020-01-08 VIB vzw Muscarinic acetylcholine receptor binding agents and uses thereof
CA2906259C (en) 2013-03-15 2022-12-06 Vib Vzw Anti-mmr single variable domains for prognosis and monitoring of cardiovascular diseases
PL2992101T3 (en) 2013-04-29 2019-05-31 Agrosavfe Nv Agrochemical compositions comprising antibodies binding to sphingolipids
NL1040254C2 (en) 2013-05-17 2014-11-24 Ablynx Nv Stable formulations of immunoglobulin single variable domains and uses thereof.
US10017559B2 (en) 2013-11-04 2018-07-10 INSERM (Institut National de la Santé et de la Recherche Médicale Synthetic single domain antibody
EP2883883A1 (en) 2013-12-16 2015-06-17 Cardio3 Biosciences S.A. Therapeutic targets and agents useful in treating ischemia reperfusion injury
WO2015121092A1 (en) 2014-01-30 2015-08-20 Vib Vzw Opioid receptor binding agents and uses thereof
MX2016011561A (en) * 2014-03-06 2017-04-13 Nat Res Council Canada Insulin-like growth factor 1 receptor -specific antibodies and uses thereof.
PE20170088A1 (en) * 2014-03-06 2017-03-09 Nat Res Council Canada SPECIFIC ANTIBODIES OF THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR AND USES OF THEM
UA120047C2 (en) * 2014-03-06 2019-09-25 Нешнл Рісеч Каунсіл Оф Канада ANTIGEN-BINDING ANTIBODY FRAGMENT THAT SPECIFICALLY BINDS TO THE INSULIN-LIKE GROWTH FACTOR RECEPTOR 1 (IGF1R)
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
WO2016016329A1 (en) 2014-07-29 2016-02-04 Vrije Universiteit Brussel Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response
CN106573983B (en) 2014-07-29 2018-05-25 布鲁塞尔自由大学 For the radiolabeled antibody fragment used in the prevention and/or treatment of cancer
BR112017009330A2 (en) 2014-11-05 2017-12-19 Agrosavfe N V transgenic plant comprising a polynucleotide encoding a heavy chain antibody variable domain
JP6862343B2 (en) 2014-12-19 2021-04-21 アブリンクス エン．ヴェー． Cysteine-bonded nanobody dimer
BR112017023158A2 (en) 2015-04-30 2018-07-24 Harvard College anti-ap2 antibodies and antigen binding agents to treat metabolic disorders
CN111234027A (en) 2015-05-21 2020-06-05 哈普恩治疗公司 Trispecific binding proteins and methods of use
MX390949B (en) 2015-07-17 2025-03-21 Univ Brussel Vrije Radiolabeled antibody fragments for use in cancer treatment.
CN105384825B (en) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
US20170059561A1 (en) * 2015-08-28 2017-03-02 The Florida International University Board Of Trustees Thermally Stable Electrochemical Sensor With Long Shelf-Life
CA3006398A1 (en) 2015-11-27 2017-06-01 Ablynx Nv Polypeptides inhibiting cd40l
CN116769054A (en) 2016-02-05 2023-09-19 奥里尼斯生物科学私人有限公司 Bispecific signaling agents and uses thereof
US11248057B2 (en) 2016-03-07 2022-02-15 Vib Vzw CD20 binding single domain antibodies
CA3017813C (en) 2016-03-17 2021-12-07 Oslo Universitetssykehus Hf Fusion proteins targeting tumour associated macrophages for treating cancer
CN107304419A (en) * 2016-04-22 2017-10-31 中国农业科学院兰州兽医研究所 The yeast cDNA library and its construction method and purposes of a kind of swine fever virus resistant VHH antibody
WO2017182605A1 (en) 2016-04-22 2017-10-26 Université Libre de Bruxelles A new biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells
US11243214B2 (en) 2016-04-22 2022-02-08 Université Libre de Bruxelles Biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells
WO2017191108A1 (en) 2016-05-02 2017-11-09 Ablynx Nv Treatment of rsv infection
CN105821480A (en) * 2016-05-03 2016-08-03 中国农业科学院兰州兽医研究所 Anti-orf virus two-humped camel VHH heavy-chain single-domain antibody cDNA library and preparation method thereof
CN109563141A (en) 2016-05-13 2019-04-02 奥里尼斯生物科学公司 To the therapeutic targeting of cellular structures
BR112018073739A2 (en) 2016-05-20 2019-02-26 Harpoon Therapeutics, Inc. single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
CN109641046B (en) 2016-05-20 2023-11-07 哈普恩治疗公司 Single-chain variable fragment CD3-binding protein
EP3463482B1 (en) 2016-06-07 2021-10-06 The Brigham and Women's Hospital, Inc. Methods relating to t peripheral helper cells in autoantibody-associated conditions
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
WO2018007442A1 (en) 2016-07-06 2018-01-11 Ablynx N.V. Treatment of il-6r related diseases
WO2018014260A1 (en) 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
WO2018029182A1 (en) 2016-08-08 2018-02-15 Ablynx N.V. Il-6r single variable domain antibodies for treatment of il-6r related diseases
EP3512880A1 (en) 2016-09-15 2019-07-24 Ablynx NV Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
AU2017361846B2 (en) 2016-11-16 2024-08-22 Ablynx Nv T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta
JP6812551B2 (en) 2016-11-23 2021-01-13 ハープーン セラピューティクス，インク． Prostate-specific membrane antigen-binding protein
JP7215997B2 (en) 2016-11-23 2023-01-31 ハープーン セラピューティクス，インク． Trispecific proteins targeting prostate specific membrane antigen (PSMA) and methods of use
WO2018099968A1 (en) 2016-11-29 2018-06-07 Ablynx N.V. Treatment of infection by respiratory syncytial virus (rsv)
JP7449092B2 (en) * 2017-01-30 2024-03-13 ナショナル リサーチ カウンシル オブ カナダ Blood-brain barrier migration compounds and their uses
EP3577133A1 (en) 2017-02-06 2019-12-11 Orionis Biosciences NV Targeted chimeric proteins and uses thereof
US11964002B2 (en) 2017-02-28 2024-04-23 Vib Vzw Means and methods for oral protein delivery
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
US20200033347A1 (en) 2017-04-18 2020-01-30 Universite Libre De Bruxelles Biomarkers And Targets For Proliferative Diseases
WO2018206734A1 (en) 2017-05-11 2018-11-15 Vib Vzw Glycosylation of variable immunoglobulin domains
CA3063359A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Mesothelin binding proteins
CA3063362A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
US11225514B2 (en) 2017-05-30 2022-01-18 The Regents Of The University Of California Nanobodies against cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif)
CN110997716B (en) 2017-06-02 2024-03-15 埃博灵克斯股份有限公司 aggrecan-binding immunoglobulins
KR102778120B1 (en) 2017-06-02 2025-03-06 메르크 파텐트 게엠베하 MMP13 binding immunoglobulin
IL270951B2 (en) 2017-06-02 2025-05-01 Merck Patent Gmbh Polypeptides binding adamts5, mmp13 and aggrecan
LT3630847T (en) 2017-06-02 2024-12-10 Merck Patent Gmbh ADAMTS-BINDING IMMUNOGLOBULINS
WO2019000223A1 (en) 2017-06-27 2019-01-03 Nanjing Legend Biotech Co., Ltd. Chimeric antibody immune effctor cell engagers and methods of use thereof
CA3070253A1 (en) 2017-07-19 2019-01-24 Vib Vzw Serum albumin binding agents
UA129446C2 (en) 2017-10-13 2025-04-30 Гарпун Терап'Ютікс, Інк. TRISPECIFIC PROTEINS AND METHODS OF THEIR APPLICATION
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B cell maturation antigen binding proteins
WO2019086548A1 (en) 2017-10-31 2019-05-09 Vib Vzw Novel antigen-binding chimeric proteins and methods and uses thereof
CN117050184A (en) 2017-12-28 2023-11-14 南京传奇生物科技有限公司 Single domain antibodies to TIGIT and variants thereof
JP7366908B2 (en) 2018-01-15 2023-10-23 ナンジン レジェンド バイオテック カンパニー，リミテッド Single domain antibodies against PD-1 and variants thereof
WO2019148089A1 (en) 2018-01-26 2019-08-01 Orionis Biosciences Inc. Xcr1 binding agents and uses thereof
MX2020008208A (en) 2018-02-05 2020-11-09 Orionis Biosciences Inc Fibroblast binding agents and use thereof.
WO2019155041A1 (en) 2018-02-12 2019-08-15 Vib Vzw Gβγ COMPLEX ANTIBODIES AND USES THEREOF
EP3758742A1 (en) 2018-03-01 2021-01-06 Vrije Universiteit Brussel Human pd-l1-binding immunoglobulins
KR102879500B1 (en) 2018-03-23 2025-10-31 유니베르시테 리브레 드 브룩크젤즈 WNT signaling agonist molecules
CN112384236A (en) 2018-03-27 2021-02-19 Umc乌得勒支控股有限公司 Targeted thrombolysis for the treatment of microvascular thrombosis
AU2019241350B2 (en) 2018-03-30 2025-10-02 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies against LAG-3 and uses thereof
WO2019222283A1 (en) 2018-05-14 2019-11-21 Harpoon Therapeutics, Inc. Binding moiety for conditional activation of immunoglobulin molecules
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
EP3856771A4 (en) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages
EP3962599A1 (en) 2019-04-30 2022-03-09 Vib Vzw Cystic fibrosis transmembrane conductance regulator stabilizing agents
KR20220008866A (en) 2019-05-14 2022-01-21 하푼 테라퓨틱스, 인크. EpCAM binding proteins and methods of use
WO2020239934A1 (en) 2019-05-28 2020-12-03 Vib Vzw Cd8+ t-cells lacking plexins and their application in cancer treatment
US20220220197A1 (en) 2019-05-28 2022-07-14 Vib Vzw Cancer Treatment by Targeting Plexins in the Immune Compartment
CN110981958B (en) * 2019-08-23 2020-10-20 四川大学华西医院 A PD-L1 antibody
WO2021078786A1 (en) 2019-10-21 2021-04-29 Vib Vzw Nanodisc-specific antigen-binding chimeric proteins
CN110776564B (en) * 2019-10-30 2022-02-08 西北农林科技大学 Two-strain anti-newcastle disease virus nano antibody and expression preparation method and application thereof
WO2021105438A1 (en) 2019-11-27 2021-06-03 Vib Vzw Positive allosteric modulators of the calcium-sensing receptor
GB201918279D0 (en) 2019-12-12 2020-01-29 Vib Vzw Glycosylated single chain immunoglobulin domains
EP4077372A1 (en) 2019-12-20 2022-10-26 Vib Vzw Nanobody exchange chromatography
JP2023507369A (en) * 2019-12-20 2023-02-22 メディミューン，エルエルシー Compositions and methods for treating cancer using chimeric antigen receptors targeting glypican 3
WO2021142086A1 (en) 2020-01-08 2021-07-15 Synthis Therapeutics, Inc. Alk5 inhibitor conjugates and uses thereof
WO2021156490A2 (en) 2020-02-06 2021-08-12 Vib Vzw Corona virus binders
IL295448A (en) 2020-02-21 2022-10-01 Harpoon Therapeutics Inc Flt3 binding proteins and methods of use
JP2023514654A (en) 2020-02-25 2023-04-06 ブイアイビー ブイゼットダブリュ Allosteric regulator of leucine-rich repeat kinase 2
AU2021250446A1 (en) 2020-03-31 2022-11-17 Biotalys NV Anti-fungal polypeptides
US20230279115A1 (en) 2020-04-22 2023-09-07 Mabwell (shanghai) Bioscience Co., Ltd. Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof
WO2021229104A1 (en) 2020-05-15 2021-11-18 Université de Liège Anti-cd38 single-domain antibodies in disease monitoring and treatment
AU2021274883A1 (en) 2020-05-20 2022-12-01 Centre National De La Recherche Scientifique - Cnrs - Synthetic single domain library
CN116157510A (en) 2020-06-17 2023-05-23 詹森生物科技公司 Materials and methods for the production of pluripotent stem cells
WO2022003156A1 (en) 2020-07-02 2022-01-06 Oncurious Nv Ccr8 non-blocking binders
AU2021306786A1 (en) 2020-07-10 2023-02-16 Jiangxi Jemincare Group Co., Ltd. Anti-IgE engineered antibody and application thereof
EP4189061A1 (en) 2020-07-31 2023-06-07 Biotalys NV Methods of increasing recombinant protein yields
WO2022063957A1 (en) 2020-09-24 2022-03-31 Vib Vzw Biomarker for anti-tumor therapy
WO2022063947A1 (en) 2020-09-24 2022-03-31 Vib Vzw Combination of p2y6 inhibitors and immune checkpoint inhibitors
CA3195687A1 (en) 2020-09-25 2022-03-31 Ablynx Nv Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l
WO2022117569A1 (en) 2020-12-02 2022-06-09 Oncurious Nv A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
JP2024508207A (en) 2020-12-02 2024-02-26 ブイアイビー ブイゼットダブリュ LTBR agonists in combination therapy against cancer
WO2022120024A1 (en) * 2020-12-03 2022-06-09 Tavotek Biotherapeutics (Hong Kong) Limited Variable heavy chain only libraries, methods of preparation thereof, and uses thereof
KR20230123497A (en) 2020-12-18 2023-08-23 아블린쓰 엔.브이. Polypeptide comprising an immunoglobulin single variable domain targeting IL-6 and TNF-α
GB202020502D0 (en) 2020-12-23 2021-02-03 Vib Vzw Antibody composistion for treatment of corona virus infection
EP4267618A1 (en) 2020-12-24 2023-11-01 Vib Vzw Non-blocking human ccr8 binders
WO2022136650A1 (en) 2020-12-24 2022-06-30 Oncurious Nv Murine cross-reactive human ccr8 binders
EP4267617A1 (en) 2020-12-24 2023-11-01 Vib Vzw Human ccr8 binders
WO2022156908A1 (en) 2021-01-25 2022-07-28 Vrije Universiteit Brussel Method for preparing a lyophilized composition
WO2022156907A1 (en) 2021-01-25 2022-07-28 Vrije Universiteit Brussel Method and kit for labeling a biomolecule with one or more detectable labels, including a radiolabel
WO2022157373A1 (en) 2021-01-25 2022-07-28 Vrije Universiteit Brussel Compositions and kits for in vivo imaging of cardiac sarcoidosis
KR20230141853A (en) 2021-02-05 2023-10-10 브이아이비 브이지더블유 Sabecovirus binding agent
CN117794566A (en) 2021-02-05 2024-03-29 Vib研究所 Sabei virus binding agent
CA3211257A1 (en) 2021-02-17 2022-08-25 Vib Vzw Inhibition of slc4a4 in the treatment of cancer
JP7773239B2 (en) 2021-02-19 2025-11-19 シャペロン インク． Bispecific single domain antibodies against PD-L1 and CD47 and uses thereof
EP4294516A1 (en) 2021-02-19 2023-12-27 Vib Vzw Cation-independent mannose-6-phosphate receptor binders
CA3209052A1 (en) 2021-02-19 2022-08-25 Rafael Cristian CASELLAS Single domain antibodies that neutralize sars-cov-2
AU2022222994B2 (en) 2021-02-19 2025-11-27 Shaperon Inc. Single domain antibody against cd47 and use thereof
BR112023016706A2 (en) 2021-02-19 2023-10-31 Seoul Nat Univ R&Db Foundation Antibody or an antigen-binding fragment thereof, nucleic acid molecule, methods for producing an antibody or an antigen-binding fragment thereof and for detecting cluster of differentiation 47 or determining an amount of cluster of differentiation 47 in a sample, and, use of the antibody or an antigen-binding fragment thereof
WO2022199804A1 (en) 2021-03-24 2022-09-29 Vib Vzw Nek6 inhibition to treat als and ftd
WO2022242892A1 (en) 2021-05-17 2022-11-24 Université de Liège Anti-cd38 single-domain antibodies in disease monitoring and treatment
WO2022268993A1 (en) 2021-06-23 2022-12-29 Vib Vzw Means and methods for selection of specific binders
WO2022269473A1 (en) 2021-06-23 2022-12-29 Janssen Biotech, Inc. Materials and methods for hinge regions in functional exogenous receptors
US20240343811A1 (en) 2021-06-29 2024-10-17 Shandong Simcere Biopharmacutical Co., Ltd. Cd16 antibody and use thereof
EP4377352A2 (en) 2021-07-30 2024-06-05 Vib Vzw Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation
CA3227972A1 (en) 2021-07-30 2023-02-02 Shandong Simcere Biopharmaceutical Co., Ltd. Anti-pvrig/anti-tigit bispecific antibodies and applications thereof
US20250009908A1 (en) 2021-10-05 2025-01-09 Vrije Universiteit Brussel Fluorescently Labeled Immunoglobulin Single Variable Domains
WO2023057601A1 (en) 2021-10-06 2023-04-13 Biotalys NV Anti-fungal polypeptides
CN118696058A (en) 2021-12-03 2024-09-24 山东先声生物制药有限公司 Anti-BCMA nanoantibodies and their applications
EP4448574A1 (en) 2021-12-17 2024-10-23 Ablynx N.V. Polypeptides comprising immunoglobulin single variable domains targeting tcralphabeta, cd33 and cd123
JP2025501206A (en) 2021-12-31 2025-01-17 山▲東▼先声生物制▲薬▼有限公司 GPRC5D antibody and its applications
EP4463479A1 (en) 2022-01-12 2024-11-20 Vib Vzw Human ntcp binders for therapeutic use and liver-specific targeted delivery
WO2023148291A1 (en) 2022-02-02 2023-08-10 Biotalys NV Methods for genome editing
WO2023148397A1 (en) 2022-02-07 2023-08-10 Vib Vzw Engineered stabilizing aglycosylated fc-regions
EP4508082A1 (en) 2022-04-13 2025-02-19 Vib Vzw An ltbr agonist in combination therapy against cancer
WO2023213751A1 (en) 2022-05-02 2023-11-09 Umc Utrecht Holding B.V Single domain antibodies for the detection of plasmin-cleaved vwf
WO2023215888A2 (en) * 2022-05-06 2023-11-09 The Children's Medical Center Corporation Binding agents for bcl11a and methods of use thereof
US20250313611A1 (en) 2022-05-18 2025-10-09 Vib Vzw Sarbecovirus spike s2 subunit binders
JP2025522351A (en) 2022-06-06 2025-07-15 山▲東▼先声生物制▲薬▼有限公司 Multispecific antibodies targeting BCMA, GPRC5D and T cells and their applications
JP2025523630A (en) 2022-07-04 2025-07-23 ブイアイビー ブイゼットダブリュ Blood-cerebrospinal fluid barrier crossing antibodies
CA3262611A1 (en) 2022-07-22 2024-01-25 Janssen Biotech Inc Enhanced transfer of genetic instructions to effector immune cells
WO2024068744A1 (en) 2022-09-27 2024-04-04 Vib Vzw Antivirals against human parainfluenza virus
EP4349374A1 (en) 2022-10-05 2024-04-10 Vrije Universiteit Brussel Anti-urokinase plasminogen activator receptor immunoglobulin single variable domains
WO2024083843A1 (en) 2022-10-18 2024-04-25 Confo Therapeutics N.V. Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
JP2025537809A (en) 2022-11-15 2025-11-20 アイメック・ヴェーゼットウェー Methods and systems for droplet manipulation - Patents.com
EP4634214A1 (en) 2022-12-15 2025-10-22 Aarhus Universitet Synthetic activation of multimeric transmembrane receptors
WO2024133937A1 (en) 2022-12-22 2024-06-27 Biotalys NV Methods for genome editing
WO2024145551A1 (en) 2022-12-29 2024-07-04 Biotalys NV Agrochemical compositions
EP4642233A1 (en) 2022-12-30 2025-11-05 Biotalys NV Agglomerate
WO2024141641A2 (en) 2022-12-30 2024-07-04 Biotalys NV Secretion signals
WO2024141638A1 (en) 2022-12-30 2024-07-04 Biotalys NV Self-emulsifiable concentrate
WO2024156888A1 (en) 2023-01-27 2024-08-02 Vib Vzw Cd163-binding conjugates
EP4655323A1 (en) 2023-01-27 2025-12-03 Vrije Universiteit Brussel Cd8b-binding polypeptides
EP4662246A1 (en) 2023-02-09 2025-12-17 Seni-Preps B.V. Immunoglobulin single variable domains that inhibit urease and use thereof
WO2024175787A1 (en) 2023-02-24 2024-08-29 Vrije Universiteit Brussel Anti-inflammatory pannexin 1 channel inhibitors
US20240344078A1 (en) 2023-03-14 2024-10-17 Aarhus Universitet Genetically altered nfr5 receptor kinases
AU2024243709A1 (en) 2023-04-03 2025-11-06 Katholieke Universiteit Leuven Blood-brain barrier crossing antibodies
WO2024231348A1 (en) 2023-05-11 2024-11-14 Vib Vzw Slc4a4/nbce1 inhibitors
WO2024240162A1 (en) 2023-05-23 2024-11-28 Shanghai Allygen Biologics Co., Ltd. Pd-l1 and trop-2 targeting conjugates comprising effector molecules and uses thereof
WO2024261344A1 (en) 2023-06-23 2024-12-26 Vib Vzw Novel binders targeting the multi-drug resistant pathogen acinetobacter baumannii
EP4483951A1 (en) 2023-06-30 2025-01-01 Université de Liège Single-domain antibody for inhibition of neutrophil elastase activity
WO2025034806A1 (en) 2023-08-08 2025-02-13 Wisconsin Alumni Research Foundation Single-domain antibodies and variants thereof against fibroblast activation protein
NL2036011B1 (en) 2023-10-12 2025-04-30 Synapse Res Institute Molecules for reversing anti-coagulant activity of direct oral anticoagulants
WO2025088085A1 (en) 2023-10-26 2025-05-01 Abscint Nv Image guided biopsy of her2 positive lesions
WO2025093683A1 (en) 2023-11-03 2025-05-08 Neuvasq Biotechnologies Sa Wnt7 signaling agonists
WO2025109176A1 (en) 2023-11-22 2025-05-30 Exevir Bio Bv Optimized sarbecovirus spike s2 subunit binders and compositions comprising the same
WO2025125577A1 (en) 2023-12-14 2025-06-19 Vib Vzw Antibodies against influenza b virus
EP4574981A1 (en) 2023-12-22 2025-06-25 Biotalys NV Anti-fungal vhh antibodies
WO2025178959A1 (en) 2024-02-20 2025-08-28 University Of Georgia Research Foundation, Inc. Single-domain antibodies and variants thereof against tab1
WO2025181155A1 (en) 2024-02-26 2025-09-04 Vib Vzw Human beta-glucocerebrosidase binders and uses thereof
WO2025196308A1 (en) 2024-03-22 2025-09-25 Vib Vzw Means and methods for displaying fc-containing proteins on cells and selection thereof
WO2025219231A1 (en) 2024-04-15 2025-10-23 Vib Vzw Computer-implemented means and methods for the de novo design of antibodies targeting a specific epitope

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182107A (en) 1989-09-07 1993-01-26 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
US6172197B1 (en) * 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US5792457A (en) 1991-05-03 1998-08-11 The Rockefeller University Antibody recognizing endothelial cell ligand for leukocyte CR3
EP0656946B2 (en) 1992-08-21 2010-03-31 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US5855885A (en) 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
EP0739981A1 (en) * 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
CA2253633A1 (en) * 1997-12-03 1999-06-03 Boehringer Mannheim Corporation Complex specific antibodies, method of preparation and uses thereof
WO1999037681A2 (en) 1998-01-26 1999-07-29 Unilever Plc Method for producing antibody fragments
US20020155604A1 (en) * 1998-02-19 2002-10-24 Jeffrey A. Ledbetter Compositions and methods for regulating lymphocyte activation
WO2000043507A1 (en) * 1999-01-19 2000-07-27 Unilever Plc Method for producing antibody fragments

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