AU2001266791A1

AU2001266791A1 - Identification and use of molecular markers indicating cellular reprogramming

Info

Publication number: AU2001266791A1
Application number: AU2001266791A
Authority: AU
Inventors: Lynette Childs; Kenneth J. Eilertsen; Martha Pfister-Genskow
Original assignee: Infigen Inc
Current assignee: Infigen Inc
Priority date: 2000-06-07
Filing date: 2001-06-07
Publication date: 2001-12-17
Also published as: WO2001094550A2; US20040081958A1; EP1292667A4; CA2416868A1; EP1292667A2; WO2001094550A3

Description

IDENTIFICATION AND USE OF MOLECULAR MARKERS INDICATING CELLULAR REPROGRAMMLNG

DESCRIPTION

This application is related to, and claims priority from, provisional U.S. Patent Application No. 60/209,874, filed on June 7, 2000, which is hereby incorporated by reference in its entirety, including all tables, figures, and claims.

INTRODUCTION The present invention relates in part to identifying and evaluating the molecular events associated with nuclear and cellular reprogramming. More particularly, the invention identifies one or more "expression events" occurring within cells, tissues, embryos, and or animals that signal developmental competence or ' lineage-specific development.

BACKGROUND OF THE INVENTION The following description ofthe background ofthe invention is provided simply as an aid in understanding the invention and is not admitted to describe or constitute prior art to the invention.

Researchers have been developing methods for cloning animals over the past two decades. Some reported methods include the steps of (1) isolating a cell, most often an embryonic cell; (2) inserting that cell or a nucleus isolated from the cell into an enucleated oocyte (e.g., the nucleus ofthe oocyte was previously extracted), and

(3) allowing an embryo to develop from the nuclear transfer oocyte in vivo. These methods, while useful, are severly limited due to poor efficiencies, as measured by the birth of live animals. In bovines, for example, embryos generated by in vitro fertilization techniques result in live births at a 50% or greater efficiency; artificial insemination techniques efficiencies are 90% or better. In contrast, live birth/nuclear transfer efficiencies are about 1% or less. Current methods to assess embryo viability and developmental competence rely on subjective measurements of embryo quality. See, e.g., Overstrom, 1996, Theriogenology 45: 3-16. In the context of nuclear transfer, these methods have proven to be of limited usefulness.. When a nuclear donor cell is inserted into a recipient oocyte, the oocyte environment alters the inserted nucleus in a process referred to as "cellular reprogramming." This reprogramming can result in a developmentally competent nuclear transfer embryo; that is, an embryo able to result in a live birth. The underlying molecular mechanisms of cellular reprogramming remain poorly understood. Researchers have noted that DNA methylation patterns can be altered in the transition to developmental competence (see, e.g., Surani et al, 1990, Phil. Trans. R. Soc. Lond. B 326: 313-327; Monk, 1990, Phil. Trans. R. Soc. Lond. B 326: 299- 312; Surani, 1999, Seminars in Cell and Dev. Biol. 10: 273-277); and that certain uridylic acid-rich nuclear RNA molecules and histone subtypes change as cells transition from developmental competence to a more differentiated state (see, e.g., Ray et al, 1997, Mol. and Cell. Biochem. 177: 79-88; Clarke et al, 1998, Dev. Genet. 22: 17-30).

Researchers have also described various gene products that may be related to pluripotence (i.e., the ability of a cell to differentiate into multiple cell lineages) and/or totipotence (i.e., the ability of a cell to differentiate into all the cells of an animal). Some possible examples are the oct-3 and oct-4 genes in mice (see, e.g., Rosner et al, 1990, Nature 345: 686-92; Shimazaki et al, 1993, EMBOJ. 12: 4489- 4498; Saijoh et al., 1996, Genes to Cells 1: 239-252; Wang and Schultz, 1996, Biochem. Cell Biol. 74: 579-584; Yeom et al, 1996, Development 122: 881-894;

Brehm et al, 1997, Mol. and Cell. Biol. 17: 154-162; Brehm et al, Ada Pathol Microbiol. et Immunol Scand. 106: 114-126; Pesce et α/., 1998, BioEssays 20: 722- 732; and Pesce, 1999, Cells Tissues Organs 165: 144-152); and various mouse homeobox genes (see, e.g., Webb et al, 1993, Genomics 18: 464-466; and Chapman et al, 1997, Genomics 46: 223-33).

Moreover, researchers have also attempted to identify gene products that may be related to the ability of a pluripotent cell to differentiate into specific cell lineages, and to isolate specific stem cell populations. See, e.g., Bain et al, 1992, Soc. Neurosci. Abst. 18: 612 (abstract no. 265.13); Bain et al, 1993, Mol Brain Res. 17: 23-30; Lelias et al, 1993, Proc. Natl. Acad. Sci. USA 90: 1479-1483; Urven et al,

1993, Biol. Reprod. 48: 564-574; U.S. Patent No. 5,639,618, issued on June 17, 1997 to Gay; Hendrikx et al, 1997, Exper. Hematol. 25: 878 (abstract no. 522); Walther and Bader, 1999, Mol. Brain Res. 68: 55-63; and U.S. Patent No. 5,874,301, issued on February 23, 1999 to Keller et al.

Additionally, researchers have developed a trap vector approach to identify potential developmentally related or lineage related genes. See, e.g., von Melchner et al, 1992, Genes and Dev. 6: 919-927; Reddy et al., 1992, Proc. Natl. Acad. Sci. USA

89: 6721-6725; Bruyns et al., 1994, Br. J. Haematol 87 (Suppl. 1): 92 (abstract no. 362); Baker et al., 1997, Dev. Biol. 185: 201-214; Muth et al., 1998, Dev. Dynamics 212: 277-283; U.S. Patent No. 5,922,601, issued on July 13, 1999 to Baetscher et al.; and U.S. Patent No. 5,928,888, issued on July 27, 1999 to Whitney.

SUMMARY OF THE INVENTION

The present invention concerns identifying and evaluating the molecular events associated with cellular reprogramming. More particularly, the invention identifies one or more "expression events" occurring within cells, tissues, embryos, and/or animals that signal developmental competence, developmental incompetence, lineage-specific development, viability, totipotency, or pluripotency. These expression events can then be used to efficiently screen and select cells, tissues, embryos, fetuses and/or animals that are competent to undergo reprogramming from amongst a background of incompetent cells, tissues, embryos, fetuses and/or animals. Moreover, methods and molecules able to induce such expression events can be identified and used to induce competence in otherwise incompetent cells, tissues, embryos, fetuses and/or animals.

The materials and methods described herein can be used to increase the efficiencies of cloning by nuclear transfer procedures from a success rate of less than 1% (measured by comparing the number of nuclear transfers required to produce a single live birth) to as much as 50% or more. Among the benefits provided are the ability to optimize culture conditions for competent donor cells and embryos, to optimize oocyte, donor cell, and embryo handling procedures, and to identify those donor cells, embryos and fetuses most likely to result in a live birth.

Furthermore, the materials and methods described herein can be used to increase the efficiencies of identifying cell populations for use in cell-based therapeutics and tissue regeneration. Among the benefits provided are the ability to optimize culture conditions for inducing stem cell populations to differentiate along a specific selected cell lineage, and to identify those stem cell populations most likely to provide a desired therapeutic benefit.

Thus, in a first aspect, the invention concerns the identification and use of one or more expressed sequence tags, the expression of which can be used to identify a cell, embryo, or fetus as being developmentally competent or developmentally incompetent.

In a first embodiment, cells can be identified as being developmentally competent based on the expression of an expressed sequence tag (or its complementary sequence) known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence. Similarly, cells can be identified as being developmentally incompetent based on the expression of an expressed sequence tag (or its complementary sequence) known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent.

The term "expressed sequence tag," or "EST" as used herein refers to an isolated, enriched, or purified nucleic acid sequence representing a gene that is expressed in a tissue-specific or developmentally-specific manner by one or more cells. Such ESTs can be referred to as being "differentially expressed" in two cells or tissues. Preferably, an EST is obtained by sequencing one or more complementary

DNA ("cDNA") molecules prepared from messenger RNA ("mRNA") strands present in a specific cell or tissue type. Methods for preparing cDNA molecules are well known to the skilled artisan. See, e.g., Sambrook, et al, 1989, Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Press, Plainview, NY. In certain embodiments, an EST is obtained from sequences present in a tissue-specific or developmentally-specific cDNA library. An EST may represent the sequence of a full length gene or mRNA molecule, or may contain only a partial sequence. While an EST is preferably a sequence corresponding to an mRNA molecule itself (a "sense" sequence), in certain preferred embodiments an EST can be a sequence that is complementary to a nucleic acid molecule expressed in a tissue-specific or developmentally-specific manner (an "antisense" sequence). The term EST can refer to a sequence in any digital or alphanumeric form, such as a computer file, computer display, or printed table describing each sequence, or to the EST nucleic acid molecules themselves. An EST that is characteristic of a specific cell or tissue type may be referred to as a "marker" of that cell or tissue type.

While the present invention is described in terms of ESTs generated from a cDNA library, the skilled artisan will understand that nucleic acid sequences representing genes that are expressed in a tissue-specific or developmentally-specific manner by one or more cells can also be obtained from genomic DNA sequences. For example, Shoemaker et al, Nature 409: 922-927 describes microarray-based methods using exon arrays. Thus, the ESTs ofthe present invention may come from genomic sources, as well as from mRNA or cDNA sources.

Particularly preferred are one or more ESTs that are markers of developmental competence of cells, developmental incompetence of cells, developmental competence of embryos, developmental incompetence of embryos, lineage-specific development of cells, viability of cells, viability of embryos, viability of fetuses, totipotency of cells, pluripotency of cells, oocyte competence for nuclear transfer, oocyte incompetence for nuclear transfer, oocyte competence for in vitro fertilization, and oocyte incompetence for in vitro fertilization.

In preferred embodiments, an EST is at least about 9 nucleotides in length, at least about 10 nucleotides in length, at least about 11 nucleotides in length, at least about 12 nucleotides in length, at least about 13 nucleotides in length, at least about 14 nucleotides in length, at least about 15 nucleotides in length, at least about 16 nucleotides in length, at least about 17 nucleotides in length, at least about 18 nucleotides in length, at least about 19 nucleotides in length, at least about 20 nucleotides in length, at least about 25 nucleotides in length, at least about 30 nucleotides in length, at least about 35 nucleotides in length, at least about 40 nucleotides in length, at least about 45 nucleotides in length, at least about 50 nucleotides in length, at least about 55 nucleotides in length, at least about 60 nucleotides in length, at least about 65 nucleotides in length, at least about 70 nucleotides in length, at least about 75 nucleotides in length, at least about 80 ( nucleotides in length, at least about 90 nucleotides in length, at least about 100 nucleotides in length, at least about 125 nucleotides in length, at least about 150 nucleotides in length, at least about 175 nucleotides in length, at least about 200 nucleotides in length, at least about 300 nucleotides in length, at least about 400 nucleotides in length, at least about 500 nucleotides in length, at least about 1,000 nucleotides in length, at least about 5,000 nucleotides in length, at least about 10,000 nucleotides in length, at least about 50,000 nucleotides in length, and at least about 100,000 nucleotides in length.

The terms "complementary" and "complement" as used herein in reference to sequences refers to the ability of each ofthe various nucleotides to form a binding pair by hydrogen bonding with a specific complementary nucleotide. For example, the skilled artisan understands that guanine and cytosine are complementary nucleotides, as are adenine and thymine or uracil. A second sequence is complementary to a first sequence when substantially every nucleotide in the first sequence can be paired in register to a nucleotide in the second sequence. Two nucleic acid strands containing such complementary sequences can "hybridize," or form a double stranded nucleic acid molecule. Nucleic acid hybridization techniques are well known in the art. See, e.g., Sambrook, et al, 1989, Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Press, Plainview, NY.; U.S. Patent No. 5,935,788, issued on August 10, 1999 to Burmer et al, entitled "Subtractive Hybridization Techniques for Identifying Differentially Expressed and Commonly Expressed Nucleic Acid;" and U.S. Patent No. 5,773,213, issued on June 30, 1998 to Gullans et al, entitled "Method for Conducting Sequential Nucleic Acid Hybridization Steps," each of which is incorporated in its entirety, including all tables, figures, and claims.

In preferred embodiments a second sequence is exactly complementary to a first sequence. In certain embodiments, however, a second sequence may contain one or more mismatched, additional, or deleted nucleotides and still be complementary to a first sequence, so long as the two strands contain sufficient complementary nucleotides for hybridization to occur. In preferred embodiments, a complementary sequence comprises 1% mismatched, additional, or deleted nucleotides, 2% mismatched, additional, or deleted nucleotides, 3% mismatched, additional, or deleted nucleotides, 4% mismatched, additional, or deleted nucleotides, 5% mismatched, additional, or deleted nucleotides, 6% mismatched, additional, or deleted nucleotides,

7% mismatched, additional, or deleted nucleotides, 8% mismatched, additional, or deleted nucleotides, 9% mismatched, additional, or deleted nucleotides, or 10% mismatched, additional, or deleted nucleotides. In particularly preferred embodiments, a sequence can be longer than its complementary sequence due to additional 5' and/or 3 ' nucleotides that do not overlap with the complementary region.

Isolated nucleic acids are unique in that they are not found in a pure or separated state in nature. Use ofthe term "isolated" indicates that a naturally occurring sequence has been removed from its normal cellular (i.e., chromosomal) environment. Thus, the sequence may be in a cell-free solution or placed in a different cellular environment. The term does not imply that the sequence is the only nucleic acid present, but that it is essentially free (about 90 - 95% pure at least) of non- nucleotide material naturally associated with it, and thus is distinguished from isolated chromosomes.

The term "enriched" in reference to nucleic acids means that the specific DNA or RNA molecule constitutes a significantly higher fraction (2- to 5-fold or more ) of the total DNA or RNA present in the cells or solution of interest than in normal or diseased cells or in the cells from wliich the sequence was taken. This could be caused by a person by preferential reduction in the amount of other DNA or RNA present, or by a preferential increase in the amount ofthe specific DNA or RNA sequence, or by a combination ofthe two. However, it should be noted that enriched does not imply that there are no other DNA or RNA molecules present, just that the relative amount ofthe nucleic acid of interest has been significantly increased. The term "significant" is used to indicate that the level of increase is useful to the person making such an increase, and generally means an increase relative to other nucleic acids of about at least 2-fold, more preferably at least 5- to 10-fold or even more. The term also does not imply that there is no DNA or RNA from other sources. DNA from other sources may, for example, comprise DNA from a yeast or bacterial genome, or a cloning or expression vector.

It is also advantageous for some purposes that a nucleic acid molecule be in purified form. In this context, "purified" does not require absolute purity (such as a homogeneous preparation). Instead, it represents an indication that the molecule is relatively more pure than in its natural environment (compared to the natural level this level should be at least 2- to 5-fold greater, e.g., in terms of mg/mL). Individual clones isolated from a cDNA library may be purified to electrophoretic homogeneity. cDNA clones are not naturally occurring, but rather are preferably obtained via ' manipulation of a partially purified naturally occurring substance, typically messenger

RNA (mRNA). The construction of a cDNA library from mRNA involves creating cDNAs by reverse transcription of mRNA. Pure individual cDNA clones can be isolated from the library by clonal selection. Thus, a process that includes the construction of a cDNA library from mRNA and isolation of distinct cDNA clones yields an approximate 10⁶-fold purification. Thus, purification of at least one order of magnitude, preferably two or three orders, and more preferably four or five orders of magnitude is expressly contemplated.

The term "expression" as used herein refers to the presence of an RNA molecule in a cell or tissue as a result ofthe transcription machinery ofthe cell or tissue. During transcription in eukaryotic cells, RNA molecules are synthesized from a complementary DNA template by one of three different RNA polymerase molecules. In most cases, the initial transcripted RNA molecule is not a functional RNA molecule, but is instead a precursor molecule that must be processed before it becomes a mature ribosomal, transfer, or messenger RNA molecule. Additionally, both primary transcripts and mature RNA molecules are subject to various degradation enzymes, and thus may be present as fragments ofthe original full length RNA molecule. The skilled artisan will therefore understand that expression can refer to the presence ofthe RNA molecule in any of these forms.

The term "developmentally competent" as used herein refers to a cell (or nucleus thereof), embryo, or fetus that is capable of developing into a live born animal. A developmentally competent cell can give rise to all ofthe cells of an animal when it is utilized as a source of nuclear donor material in a nuclear transfer procedure. In preferred embodiments, a "developmentally competent cell" has not yet been used in a nuclear transfer procedure, but is obtained from a cell line that has been demonstrated to produce cells that are capable of developing into a live born animal. Such a cell line is referred to as a "developmentally competent cell line." A developmentally competent cell can be referred to as "totipotent." A developmentally competent cell may be, but need not be, capable of passing its genetic characteristics through the germ line. In preferred embodiments, a developmentally competent cell line is so identified if 50%, 60%, 70%, 80%, or 90% of nuclear transfer embryos prepared using nuclear donors from that cell line are able to initiate pregnancy and reach 90 days of gestation in a maternal host. In other preferred embodiments, a developmentally competent cell line is so identified if 50%, 60%, 70%, 80%, or 90% of nuclear transfer embryos prepared using nuclear donors from that cell line are able to initiate pregnancy in a maternal host, and 50%, 60%, 70%, 80%, or 90% of those pregnancies result in a live birth.

The term "developmentally competent cell" and "developmentally competent cell line" may also refer to cells and cell lines expressing one or more nucleic acid sequences that are known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence. Such a nucleic acid can be referred to as a "marker" of a developmentally competent cell or cell line.

The term "developmentally incompetent" as used herein refers to a cell (or nucleus thereof), embryo, or fetus that is not capable of developing into a live born animal. In particularly preferred embodiments, a developmentally incompetent cell can give rise to all ofthe cells of an embryo or fetus when it is utilized as a source of nuclear donor material in a nuclear transfer procedure, but is incapable of giving rise to a live born animal. Thus, a developmentally incompetent cell may be "pluripotent," but is not "totipotent." In preferred embodiments, a "developmentally incompetent cell" is obtained from a cell line that has been tested for the ability to develop into a live born animal under conditions successfully used with developmentally competent cells, but has failed to demonstrate developmental competence. Such a cell line is referred to as a "developmentally incompetent cell line." In preferred embodiments, a developmentally competent cell line is so identified if less than 50%, less than 40%, less than 30%, less than 20%, or less than 10% of nuclear transfer embryos prepared using nuclear donors from that cell line are able to initiate pregnancy and reach 90 days of gestation in a maternal host.

The term "developmentally incompetent cell" and "developmentally incompetent cell line" may also refer to cells and cell lines expressing one or more nucleic acid sequences that are known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent. Such a nucleic acid can be referred to as a "marker" of a developmentally incompetent cell or cell line.

In preferred embodiments, developmentally competent and incompetent cells include, but are not limited to, cells isolated from an embryo arising from the union of two gametes in vitro or in vivo; embryonic stem cells (ES cells) arising from cultured embryonic cells (e.g., pre-blastocyst cells and inner cell mass cells); inner cell mass cells isolated from of embryos; pre-blastocyst cells; fetal cells; primordial germ cells; germ cells (e.g., embryonic germ cells); somatic cells isolated from an animal; cumulus cells; amniotic cells; fetal fibroblast cells; genital ridge cells; differentiated cells; lineage-specific cells; and totipotent cells.

The term "identifies" or "identifying" as used herein with respect to cells refers to the ability to distinguish between cells having two distinct characteristics. In preferred embodiments, a developmentally competent cell or cell line can be distinguished from a developmentally incompetent cell or cell line. In certain preferred embodiments, an EST or ESTs identify a cell or cell line as

"developmentally competent" if the EST sequences are present and/or expressed in embryos produced by nuclear transfer using a developmentally competent nuclear donor cell, but are present and/or expressed at a reduced or nondetectable level in embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell. Similarly, an EST or ESTs identify a cell or cell line as "developmentally incompetent" if the sequences are present and/or expressed in embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell, but are present and/or expressed at a reduced or nondetectable level in embryos produced by nuclear transfer using a developmentally competent nuclear donor cell.

The term "detectable level" as used herein refers to the ability of a comparison method to detect a nucleic acid molecule. The skilled artisan will understand that different comparison methods will have different sensitivities. For example, an RNA molecule present in low abundance in a cell may be below the detectable level of a hybridization assay due to the hybridization conditions used. Moreover, detection of a protein product by immunological means may not detect RNA molecules present in even moderate abundance. But it is well within the skill level ofthe ordinarily skilled artisan to determine which comparison methods may be appropriately used in specific circumstances. For example, a developmentally regulated RNA molecule may be present in high abundance in one developmental stage, but present in moderate abundance in a second developmental stage. The two developmental stages may be differentiated by a comparison method in which moderate abundance is below the detectable level, but high abundance detectable.

The term "totipotent" as used herein refers to a cell that gives rise to a live born animal. The term "totipotent" can also refer to a cell that gives rise to all ofthe cells in a particular animal. A totipotent cell can give rise to all ofthe cells of an animal when it is utilized in a procedure for developing an embryo from one or more nuclear transfer steps. Totipotent cells may also be used to generate incomplete animals such as those useful for organ harvesting, e.g., having genetic modifications to eliminate growth of an organ or appendage by manipulation of a homeotic gene. A totipotent cell may be, but need not be, capable of passing its genetic characteristics through the germ line.

The term "totipotent" as used herein is to be distinguished from the term "pluripotent." The latter term refers to a cell capable of differentiating into a number of different cell types, but that cannot give rise to all ofthe cells in a live born animal. The term "totipotent" as used herein is also to be distinguished from the term "chimer" or "chimera." The latter term refers to a developing cell mass, such as an embryo, fetus, or animal, that comprises a sub-group of cells harboring nuclear DNA with a significantly different nucleotide base sequence than the nuclear DNA of other cells in that cell mass.

The term "live born" as used herein preferably refers to an animal that exists ex utero. A "live born" animal may be an animal that is alive for at least one second from the time it exits the maternal host. A "live born" animal may not require the circulatory system of an in utero environment for survival. A "live born" animal may be an ambulatory animal. Such animals can include pre- and post-pubertal animals. As discussed previously, a live born animal may lack a portion of what exists in a physiologically normal animal of its kind.

In preferred embodiments, developmentally competent cells and developmentally incompetent cells are cultured; are cultured as cell lines; and are cultured as permanent cell lines.

The term "cultured" as used herein in reference to cells can refer to one or more cells that are undergoing cell division or not undergoing cell division in an in vitro environment. An in vitro environment can be any medium known in the art that is suitable for maintaining cells in vitro, such as suitable liquid media or agar, for example. Specific examples of suitable in vitro environments for cell cultures are described in Culture of Animal Cells: a manual of basic techniques (3^rd edition), 1994, R.I. Freshney (ed.), Wiley-Liss, Inc.; Cells: a laboratory manual (vol. 1), 1998, D.L. Spector, R.D. Goldman, L.A. Leinwand (eds.), Cold Spring Harbor Laboratory Press; and Animal Cells: culture and media, 1994, D.C. Darling, S.J. MorganJohn Wiley and Sons, Ltd., each of wliich is incorporated herein by reference in its entirety including all figures, tables, and drawings. Cells may be cultured in suspension and or in monolayers with one or more substantially similar cells. Cells may be cultured in suspension and/or in monolayers with a heterogeneous population of cells. The term

"heterogeneous" as utilized in the previous sentence can relate to any cell characteristics, such as cell type and cell cycle stage, for example. Cells may be cultured in suspension, cultured as monolayers attached to a solid support, and/or cultured on a layer of feeder cells, for example. Furthermore, cells may be successfully cultured by plating the cells in conditions where they lack cell to cell contact. Cells cultured as monolayers may be grown to confluence, where such cells will cease actively dividing due to contact inhibition. Preferably, cultured cells undergo cell division and are cultured for at least 5 days, more preferably for at least 10 days or 20 days, and most preferably for at least 30 days. Preferably, a significant number of cultured cells do not terminate while in culture. The terms "terminate" and "significant number are defined" hereafter. Nearly any type of cell can be placed in cell culture conditions. Cultured cells can be utilized to establish a cell line.

The term "cell line" as used herein refers to cultured cells that can be passaged at least one time without terminating. The invention relates to cell lines that can be passaged at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 40, 50, 60, 80, 100, and 200 or more times. Cell passaging is defined hereafter. Examples of cell lines include, but are not limited to, cell lines derived from cells isolated from an embryo arising from the union of two gametes in vitro or in vivo; embryonic stem cell lines (ES cells) arising from cultured embryonic cells (e.g., pre-blastocyst cells and inner cell mass cells); cell lines arising from inner cell mass cells isolated from of embryos; cell lines obtained from pre- blastocyst cells; cell lines obtained from fetal cells; cell lines obtained from primordial germ cells; cell lines obtained from germ cells (e.g., embryonic germ cells); cell lines obtained from somatic cells isolated from an animal; cell lines obtained from cumulus cells; cell lines obtained from amniotic cells; cell lines obtained from fetal fibroblast cells; cell lines obtained from genital ridge cells; cell lines obtained from differentiated cells; lineage-specific cell lines; and cell lines obtained from totipotent cells.

In preferred embodiments (1) a cell or a cell line ofthe present invention is a mammalian cell or cell line; (2) a mammalian cell or cell line is selected from the group consisting of canid cells or cell lines, felid cells or cell lines, murid cells or cell

• lines, leporid cells or cell lines, ursid cells or cell lines, mustelid cells or cell lines, and human and non-human primate cells or cell lines; (3) a mammalian cells or cell lines is an ungulate cells or cell lines; and (4) an ungulate cells or cell lines is selected from the group consisting of suid cells or cell lines, ovid cells or cell lines, equid cells or cell lines, bovid cells or cell lines, caprid cells or cell lines, and cervid cells or cell lines. The term "mammalian" as used herein refers to any animal ofthe class Mammalia. Preferably, a mammalian cell or cell line is a placental, a monotreme and a marsupial. Most preferably, a mammalian cell or cell line is a bovine, a porcine, and a human and non-human primate. A mammalian cell or cell line can be isolated from any source of mammalian cells including, but not limited to, a mammalian embryo, a mammalian fetus, and a mammalian animal.

The term "canid" as used herein refers to any animal ofthe family Canidae. Preferably, a canid cell or cell line is isolated from a wolf, a jackal, a fox, and a domestic dog.

The term "felid" as used herein refers to any animal ofthe family Felidae.

Preferably, a felid cell or cell line is isolated from a lion, a tiger, a leopard, a cheetah, a cougar, and a domestic cat.

The term "murid" as used herein refers to any animal ofthe family Muridae. Preferably, a murid cell or cell line is isolated from a mouse and a rat.

The term "leporid" as used herein refers to any animal ofthe family

Leporidae. Preferably, a leporid cell or cell line is isolated from a rabbit.

The term "ursid" as used herein refers to any animal ofthe family Ursidae. Preferably, a ursid cell or cell line is isolated from a bear.

The term "mustelid" as used herein refers to any animal ofthe family Mustelidae. Preferably, a mustelid cell or cell line is isolated from a weasel, a ferret, an otter, a mink, and a skunk.

The term "primate" as used herein refers to any animal ofthe Primate order. Preferably, a primate cell or cell line is isolated from an ape, a monkey, a chimpanzee, and a lemur.

The term "ungulate" as used herein refers to any animal ofthe polyphyletic group formerly known as the taxon Ungulata. Preferably, an ungulate cell or cell line is isolated from a camel, a hippopotamus, a horse, a tapir, and an elephant. Most preferably, an ungulate cell or cell line is isolated from a sheep, a cow, a goat, and a pig-

The term "ovid" as used herein refers to any animal ofthe family Ovidae. Preferably, an ovid cell or cell line is isolated from a sheep.

The term "suid" as used herein refers to any animal ofthe family Suidae.

Preferably, a suid cell or cell line is isolated from a pig or a boar.

The term "equid" as used herein refers to any animal ofthe family Equidae. Preferably, an equid cell or cell line is isolated from a zebra or an ass. Most preferably, an equid cell or cell line is isolated from a horse.

The term "bovid" as used herein refers to any animal ofthe family Bovidae.

Preferably, an bovid cell or cell line is isolated from an antelope, an oxen, a cow, a bison, and a goat.

The term "caprid" as used herein refers to any animal ofthe family Caprinae. Preferably, an caprid cell or cell line is isolated from a goat.

The term "cervid" as used herein refers to any animal ofthe family Cervidae.

Preferably, an cervid cell or cell line is isolated from a deer.

The term "terminating" and "terminate" as used herein with regard to cultured cells may refer to cells that undergo cell death, wliich can be measured using multiple techniques known to those skilled in the art (e.g., CytoTox96^® Cytotoxicity Assay, Promega, Inc. catalog no. G1780; Celltiter96^® Aqueous Cell Proliferation Assay Kit,

Promega, Inc. catalog no. G3580; and Trypan Blue solution for cytotoxicity assays, Sigma catalog no. T6146). Termination may also be a result of apoptosis, which can be measured using multiple techniques known to persons skilled in the art (e.g., Dead End™ Apoptosis Detection Kit, Promega, Inc. catalog no. G7130). Terminated cells may be identified as those that have undergone cell death and/or apoptosis and have released from a solid surface in culture. In addition, terminated cells may lack intact membranes which can be identified by procedures described above. Also, terminated cells may exhibit decreased metabolic activity, which may be caused in part by decreased enzymatic activity that can be identified by calcein AM, for example. Furthermore, termination can be refer to cell cultures where a significant number of cultured cells terminate. The term "significant number" in the preceding sentence can refer to about 80% ofthe cells in culture, preferably about 90% ofthe cells in culture, more preferably about 100% ofthe cells in culture, and most preferably 100% ofthe cells in culture.

The term "suspension" as used herein refers to cell culture conditions in which cells are not attached to a solid support. Cells proliferating in suspension can be stirred while proliferating using apparatus well known to those skilled in the art.

The term "monolayer" as used herein refers to cells that are attached to a solid support while proliferating in suitable culture conditions. A small portion of cells proliferating in a monolayer under suitable growth conditions may be attached to cells in the monolayer but not to the solid support. Preferably less than 15% of these cells are not attached to the solid support, more preferably less than 10% of these cells are not attached to the solid support, and most preferably less than 5% of these cells are not attached to the solid support.

The term "plated" or "plating" as used herein in reference to cells can refer to establishing cell cultures in vitro. For example, cells can be diluted in cell culture media and then added to a cell culture plate, dish, or flask. Cell culture plates are commonly known to a person of ordinary skill in the art. Cells may be plated at a variety of concentrations and/or cell densities.

The term "cell plating" can also extend to the term "cell passaging." Cells of the invention can be passaged using cell culture techniques well known to those skilled in the art. The term "cell passaging" can refer to a technique that involves the steps of (1) releasing cells from a solid support or substrate and disassociation of these cells, and (2) diluting the cells in media suitable for further cell proliferation. Cell passaging may also refer to removing a portion of liquid medium containing cultured cells and adding liquid medium to the original culture vessel to dilute the cells and allow further cell proliferation. In addition, cells may also be added to a new culture vessel which has been supplemented with medium suitable for further cell proliferation. The term "proliferation" as used herein in reference to cells can refer to a group of cells that can increase in number over a period of time.

The term "confluence" as used herein refers to a group of cells where a large percentage of cells are physically contacted with at least one other cell in that group. Confluence may also be defined as a group of cells that grow to a maximum cell density in the conditions provided. For example, if a group of cells can proliferate in a monolayer and they are placed in a culture vessel in a suitable growth medium, they are confluent when the monolayer has spread across a significant surface area ofthe culture vessel. The surface area covered by the cells preferably represents about 50% ofthe total surface area, more preferably represents about 70% ofthe total surface area, and most preferably represents about 90% ofthe total surface area.

In further embodiments, expressed sequence tags can be grouped in numbers of 2 or more, and up to numbers of 10,000 or more, to provide a gene expression database. The expression of one or more expressed sequence tags in the database can be used to identify cells, embryos, or fetuses as being developmentally competent or developmentally incompetent.

Preferably, a gene expression database comprises two or more expressed sequence tags (or their complementary sequences) known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence. As discussed above, such ESTs can be referred to as being "differentially expressed." Cells, embryos, and fetuses can be identified as developmentally competent based on the presence of at least one ofthe ESTs in such a gene expression database. In particularly preferred embodiments, a cell, embryo or fetus is identified as developmentally competent based on the presence of at least about 75% ofthe ESTs in such a gene expression database; at least about 90% ofthe ESTs in such a gene expression database; at least about 95% ofthe ESTs in such a gene expression database; and about 100% ofthe ESTs in such a gene expression database.

Likewise, a gene expression database preferably comprises two or more expressed sequence tags (or their complementary sequences) known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent. Cells, embryos, and fetuses can be identified as developmentally incompetent based on the presence of at least one ofthe former ESTs, and the absence ofthe latter ESTs. In particularly preferred embodiments, a cell, embryo or fetus is identified as developmentally incompetent based on the presence of at least about 75% ofthe ESTs in such a gene expression database; at least about 90% ofthe ESTs in such a gene expression database; at least about 95% ofthe ESTs in such a gene expression database; and about 100% ofthe ESTs in such a gene expression database.

Most preferably, a gene expression database comprises at least one EST (or its complementary sequence) known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence; and at least one EST (or its complementary sequence) known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent. In such embodiments, cells, embryos, and fetuses can be identified as developmentally competent based on the presence of at least one ofthe former ESTs, and the absence ofthe latter ESTs. Likewise, cells can be identified as developmentally incompetent based on the presence of at least one ofthe latter ESTs, and the absence ofthe former ESTs.

The term "gene expression database" as used herein refers to any set of two or more different ESTs. In certain preferred embodiments, a gene expression database can be a representation of two or more EST sequences in any digital or alphanumeric form, such as a computer file, computer display, or printed table describing each sequence. In other preferred embodiments, a gene expression database can be any format containing the EST nucleic acid molecules themselves. For example, a solution or a solid phase comprising two or more different ESTs can be a gene expression database as that term is used in the instant invention. In preferred embodiments, a gene expression database can contain at least about 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, 75, 100, 200, 500, 1000, 2000, 5000, 10000, 20000, 25000, 30000, 40000, 50000, or 100,000 different ESTs.

Particularly preferred are gene expression databases that contain one or more markers of developmental competence of cells, developmental incompetence of cells, developmental competence of embryos, developmental incompetence of embryos, lineage-specific development of cells, viability of cells, viability of embryos, totipotency of cells, pluripotency of cells, oocyte competence for nuclear transfer, oocyte incompetence for nuclear transfer, oocyte competence for in vitro fertilization, and oocyte incompetence for in vitro fertilization.

The term "plurality" as used herein refers to 2 or more. In preferred embodiments, a plurality can be 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, 75, 100, 200, 500, 1000, 2000, 5000, 10000, 20000, 25000, 30000, 40000, 50000, or 100000 or more.

In yet other embodiments, the invention relates to methods for identifying one or more expressed sequence tags, the expression of which can be used to identify cells, embryos, or fetuses as being developmentally competent or developmentally incompetent.

In preferred embodiments, one or more ESTs are identified by comparing one or more first nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to one or more second nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell. ESTs that signal developmental competence are identified as one or more nucleic acid molecules that are present in the population of first nucleic acid molecules, but that are not present at a detectable level in the population of second nucleic acid molecules. Likewise, one or more nucleic acid molecules that are present in the population of second nucleic acid molecules, but that are not present at a detectable level in the population of first nucleic acid molecules are identified as ESTs that signal developmental incompetence.

In particularly preferred embodiments, an EST that signals developmental competence is a nucleic acid molecule (1) present in at least about 75% of embryos produced by nuclear transfer using a developmentally competent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 75% of tested embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; (2) present in at least about 90% of embryos produced by nuclear transfer using a developmentally competent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 90% of tested embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; (3) present in at least about 95% of embryos produced by nuclear transfer using a developmentally competent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 95% of tested embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; and (4) present in at least about 100% of embryos produced by nuclear transfer using a developmentally competent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 100% of tested embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell.

In other particularly preferred embodiments, an EST that signals developmental incompetence is a nucleic acid molecule (1) present in at least about 75% of embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 75% of tested embryos produced by nuclear transfer using a developmentally competent nuclear donor cell; (2) present in at least about 90% of embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 90% of tested embryos produced by nuclear transfer using a developmentally competent nuclear donor cell; (3) present in at least about 95% of embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 95% of tested embryos produced by nuclear transfer using a developmentally competent nuclear donor cell; and (4) present in at least about 100% of embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell that are tested for the presence ofthe EST, but not present at a detectable level in at least about 100% of tested embryos produced by nuclear transfer using a developmentally competent nuclear donor cell.

The term "comparing" as used herein in reference to nucleic acid molecules refers to the process of determining the homology or identity of a first nucleic acid sequence to a second nucleic acid sequence. Methods for comparing two nucleic acid sequences are well known to the skilled artisan. In preferred embodiments, such methods can comprise comparing the two sequences in any digital or alphanumeric form, such as a computer file, computer display, or printed table describing each sequence. In this case, comparisons can be made by eye, that is, by a direct comparison by the skilled artisan, or can rely on various computer programs known in the art. See, e.g., Altschul, et al. (1997) Nucleic Acids Res. 25:3389-3402 (Gapped BLAST or PSI-BLAST), Altschul, et al. (1990) J. Mol. Biol. 215:403-410 (BLAST), and Smith, et al. (1981) J. Mol. Biol. 147:195-197 (Smith- Waterman). In other preferred embodiments, comparison methods can comprise comparing two nucleic acid molecules themselves, for example by hybridization methods such as southern blotting, northern blotting, in situ hybridization, dot or slot blotting, arrayed nucleic acids (including nucleic acid macroarrays and microarrays, particularly DNA macroarrays and microarrays), and phage display. See generally, Sambrook, et al, 1989, Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Press, Plainview, New York; U.S. Patent No. 6,004,755, issued on December 21,

1999 to B. Wang, each of which is hereby incorporated in its entirety, including all drawings, claims, and tables. In such methods, typically a nucleic acid molecule that is complementary to a first sequence is compared to a second sequence, hi particularly preferred embodiments, two nucleic acid molecules can be compared indirectly by comparing each nucleic acid to a reference nucleic acid library, preferably obtained from the same species as the source ofthe nucleic acid molecules. The term "nucleic acid library" is defined herein. The foregoing examples are not intended to be exclusive, and other methods for comparing two nucleic acid sequences known in the art are within the scope ofthe instant invention.

The term "comparing" may also refer to determining the homology or identity of one nucleic acid sequence to another by determining the homology or identity molecules produced from the nucleic acid sequences. For example, mRNA can be used by cells or by in vitro translation systems to produce proteins or peptides. These peptides or proteins can be compared by various immunological methods such as immunoblotting, competitive or noncompetitive immunoassay, and immunoprecipitation, and by various nonimmunological methods such as analytical centrifugation, amino acid analysis, sequencing, 1- and 2-dimensional electrophoresis (including both native and denaturing conditions such as SDS-PAGE), chromatography, peptide mapping, nuclear magnetic resonance, electron crystallography, and X-ray crystallography. See generally, Deutscher, ed., 1990, Methods in Enzymology, Volume 182, Academic Press, San Diego, CA. Such methods can be referred to by the skilled artisan as "proteomics" or "functional proteomics" techniques.

In preferred embodiments, a nucleic acid sequence or molecule is at least about 9 nucleotides in length, at least about 10 nucleotides in length, at least about 11 nucleotides in length, at least about 12 nucleotides in length, at least about 13 nucleotides in length, at least about 14 nucleotides in length, at least about 15 nucleotides in length, at least about 16 nucleotides in length, at least about 17 nucleotides in length, at least about 18 nucleotides in length, at least about 19 nucleotides in length, at least about 20 nucleotides in length, at least about 25 nucleotides in length, at least about 30 nucleotides in length, at least about 35 nucleotides in length, at least about 40 nucleotides in length, at least about 45 nucleotides in length, at least about 50 nucleotides in length, at least about 55 nucleotides in length, at least about 60 nucleotides in length, at least about 65 nucleotides in length, at least about 70 nucleotides in length, at least about 75 nucleotides in length, at least about 80 nucleotides in length, at least about 90 nucleotides in length, at least about 100 nucleotides in length, at least about 125 nucleotides in length, at least about 150 nucleotides in length, at least about 175 nucleotides in length, at least about 200 nucleotides in length, at least about 300 nucleotides in length, at least about 400 nucleotides in length, at least about 500 nucleotides in length, at least about 750 nucleotides in length, at least about 1000 nucleotides in length, at least about 1250 nucleotides in length, at least about 1500 nucleotides in length, at least about 2000 nucleotides in length, and at least about 3000 nucleotides in length. The term "homology" as used herein in reference to nucleic acid molecules refers to the amount of sequence similarity between a first and a second nucleic acid molecule. Two molecules displaying sufficient homology are said to be "homologous" to one another. The skilled artisan will understand that a second sequence may contain one or more mismatched, additional, or deleted nucleotides and still be homologous to a first sequence. In preferred embodiments, a homologous sequence comprises 1% mismatched, additional, or deleted nucleotides, 2% mismatched, additional, or deleted nucleotides, 3% mismatched, additional, or deleted nucleotides, 4% mismatched, additional, or deleted nucleotides, 5% mismatched, additional, or deleted nucleotides, 6% mismatched, additional, or deleted nucleotides,

7% mismatched, additional, or deleted nucleotides, 8% mismatched, additional, or deleted nucleotides, 9% mismatched, additional, or deleted nucleotides, or 10% mismatched, additional, or deleted nucleotides. A sequence displaying no mismatched, additional, or deleted nucleotides is said to be "identical" to a first sequence. In particularly preferred embodiments, a sequence can be longer than a homologous or identical sequence due to additional 5' and/or 3' nucleotides that do not overlap with the homologous or identical region.

In certain embodiments, two molecules are referred to as homologous if they contain sufficient sequence identity that a third nucleic acid molecule used as a probe is capable of hybridizing to both molecules. In particularly preferred embodiments, the probe molecule is complementary to one ofthe two homologous molecules. The skilled artisan will understand that the amount of homology required between the two molecules such that a probe will bind to both can be variable, depending on the stringency ofthe hybridization conditions employed.

Homology of two nucleic acid molecules may also be determined from assessing the amount of sequence similarity between a first and a second molecule produced from the nucleic acid sequences. For example, peptides or proteins can be compared by the various methods described above, and homologous nucleic acids identified based on similar or identical peptide maps, amino acid sequences, antibody bindings, etc. The term "identifying" as used herein with respect to nucleic acid molecules refers to selecting one or more molecules exhibiting identity or homology to a target nucleic acid sequence of interest. In preferred embodiments, identifying can refer to selecting sequences representing one or more nucleic acid molecules in any digital or alphanumeric form, such as a computer file, computer display, or printed table describing each sequence. In other preferred embodiments, identifying can comprise selecting one or more nucleic acid molecules themselves.

The terms "nuclear transfer" and "nuclear transfer procedure" as used herein refers to introducing a full complement of nuclear DNA from one cell to an enucleated cell. Nuclear transfer methods are well known to a person of ordinary skill in the art. See, U.S. Patent No. 4,994,384 to Prather et al, entitled "Multiplying Bovine Embryos," issued on February 19, 1991; U.S. Patent No. 5,057,420 to Massey, entitled "Bovine Nuclear Transplantation," issued on October 15, 1991; U.S. Patent No. 5,994,619, issued on November 30, 1999 to Stice et al; U.K. Patents Nos. GB 2,318,578 GB 2,331,751, issued on January 19, 2000 to Campbell et al. and

Wilmut et al, respectively, entitled "Quiescent Cell Populations For Nuclear Transfer"; U.S. Patent No. 6,011,197 to Strelchenko et al, entitled "Method of Cloning Bovines Using Reprogrammed Non-Embryonic Bovine Cells," issued on January 4, 2000; U.S. Patent No. 6,107,543; Proc. Nat'l. Acad. Sci. USA 96: 14984- 14989 (1999); Nature Genetics 22: 127-128 (1999); Cell & Dev. Diol 10: 253-258

(1999); Nature Biotechnology 17: 456-461 (1999); Science 289: 1188-1190 (2000); Nature Biotechnol. 18: 1055-1059 (2000); and Nature 407: 86-90 (2000); each of which is incorporated herein by reference in its entirety, including all figures, tables, and drawings.

In a nuclear transfer procedure, a nuclear donor cell, or the nucleus thereof, is introduced into a recipient cell. A recipient cell is preferably an oocyte and is preferably enucleated. However, the invention relates in part to nuclear transfer, where a nucleus of an oocyte is not physically extracted from the nucleus. It is possible to establish a nuclear transfer embryo where nuclear DNA from the donor cell is replicated during cellular divisions. See, e.g., Wagoner et al., 1996, "Functional enucleation of bovine oocytes: effects of centrifugation and ultraviolet light," Theriogenology 46: 279-284. In addition, nuclear transfer may be accomplished by combining one nuclear donor and more than one enucleated oocyte. Also, nuclear transfer may be accomplished by combining one nuclear donor, one or more enucleated oocytes, and the cytoplasm of one or more enucleated oocytes. The resulting combination of a nuclear donor cell and a recipient cell can be referred to variously as a "nuclear transfer embryo," a "hybrid cell," or a "cybrid."

Furthermore, a nuclear donor may arise from an animal ofthe same specie from which a nuclear recipient is isolated. Alternatively, a nuclear donor may arise from an animal of a different specie from which a nuclear recipient is isolated. For example, a differentiated cell isolated from an ear punch of a water buffalo may be utilized as a nuclear donor and an oocyte isolated from a bovine animal may be utilized as a nuclear acceptor. Thus, xenospecific nuclear transfer is contemplated by the instant invention.

The term "nuclear donor" as used herein refers to any cell having nuclear DNA that can be translocated into an oocyte. A nuclear donor may be a nucleus that has been isolated from a cell. Multiple techniques are available to a person of ordinary skill in the art for isolating a nucleus from a cell and then utilizing the nucleus as a nuclear donor. See, e.g., U.S. Patent No. 4,664,097, which is hereby incoφorated by reference in its entirety including all figures, tables and drawings. Any type of cell can serve as a nuclear donor. Examples of nuclear donor cells include, but are not limited to, cultured and non-cultured cells isolated from an embryo arising from the union of two gametes in vitro or in vivo; embryonic stem cells (ES cells) arising from cultured embryonic cells (e.g., pre-blastocyst cells and inner cell mass cells); cultured and non- cultured cells arising from inner cell mass cells isolated from of embryos; cultured and non-cultured pre-blastocyst cells; cultured and non-cultured fetal cells; cultured and non-cultured primordial germ cells; cultured and non-cultured germ cells (e.g., embryonic germ cells); cultured and non-cultured somatic cells isolated from an animal; cultured and non-cultured cumulus cells; cultured and non-cultured amniotic cells; cultured and non-cultured fetal fibroblast cells; cultured and non-cultured genital ridge cells; cultured and non-cultured differentiated cells; cultured and non- cultured cells in a synchronous population; cultured and non-cultured cells in an asynchronous population; cultured and non-cultured serum-starved cells; cultured and non-cultured permanent cells; and cultured and non-cultured totipotent cells. See, e.g., Piedrahita et al, 1998, Biol. Reprod. 58: 1321-1329; Shim et al, 1997, Biol. Reprod. 57: 1089-1095; Tsung et al, 1995, Shih Yen Sheng Wu Hsueh Pao 28: 173-189; and Wheeler, 1994, Reprod. Fertil. Dev. 6: 563-568, each of which is incorporated herein by reference in its entirety including all figures, drawings, and tables. In addition, a nuclear donor may be a cell that was previously frozen or cryopreserved.

In particularly preferred embodiments, a nuclear donor cell is a transgenic cell. The term "transgenic" as used herein in reference to cells refers to a cell whose genome has been altered using recombinant DNA techniques. In preferred embodiments, a transgenic cell comprises one or more exogenous DNA sequences in its genome. In other preferred embodiments, a transgenic cell comprises a genome in which one or more endogenous genes have been deleted, duplicated, activated, or modified. In particularly preferred embodiments, a transgenic cell comprises a genome having both one or more exogenous DNA sequences, and one or more endogenous genes that have been deleted, duplicated, activated, or modified.

The term "activation" refers to any materials and methods useful for stimulating a cell to divide before, during, and after a nuclear transfer step. Cybrids may require stimulation in order to divide after a nuclear transfer has occurred. The invention pertains to any activation materials and methods known to a person of ordinary skill in the art. Although electrical pulses are sometimes sufficient for stimulating activation of cybrids, other means are sometimes useful or necessary for proper activation ofthe cybrid. Chemical materials and methods useful for activating embryos are described below in other preferred embodiments ofthe invention.

Examples of non-electrical means for activation include agents such as ethanol; inositol trisphosphate (LP₃); Ca^"1-1" ionophores (e.g., ionomycin) and protein kinase inhibitors (e.g., 6-dimethylaminopurine (DMAP)) ; temperature change; protein synthesis inhibitors (e.g., cyclohexamide); phorbol esters such as phorbol 12- myristate 13-acetate (PMA); mechanical techniques; and thapsigargin. The invention includes any activation techniques known in the art. See, e.g., U.S. Patent No. 5,496,720, entitled "Parthenogenic Oocyte Activation" to Susko-Parrish et al, issued on March 5, 1996; and U.S. Patent Application No. 09/176,395, filed on October 21, 1998, each of which is incorporated by reference herein in its entirety, including all figures, tables, and drawings.

The term "fusion" as used herein refers to the combination of portions of lipid membranes corresponding to the totipotent mammalian cell nuclear donor and the recipient oocyte. Lipid membranes can correspond to the plasma membranes of cells or nuclear membranes, for example. The fusion can occur between the nuclear donor and recipient oocyte when they are placed adjacent to one another, or when the nuclear donor is placed in the perivitelline space ofthe recipient oocyte, for example. Specific examples for translocation ofthe totipotent mammalian cell into the oocyte are described hereafter in other preferred embodiments. These techniques for translocation are fully described in the references cited previously herein in reference to nuclear transfer.

The term "electrical pulses" as used herein refers to subjecting the nuclear donor and recipient oocyte to electric current. For nuclear transfer, the nuclear donor and recipient oocyte can be aligned between electrodes and subjected to electrical current. The electrical current can be alternating current or direct current. The electrical current can be delivered to cells for a variety of different times as one pulse or as multiple pulses. The cells are typically cultured in a suitable medium for the delivery of electrical pulses. Examples of electrical pulse conditions utilized for nuclear transfer are described in the references and patents previously cited herein in reference to nuclear transfer.

The term "fusion agent" as used herein refers to any compound or biological organism that can increase the probability that portions of plasma membranes from different cells will fuse when a totipotent mammalian cell nuclear donor is placed adjacent to the recipient oocyte. In preferred embodiments fusion agents are selected from the group consisting of polyethylene glycol (PEG), trypsin, dimethylsulfoxide (DMSO), lectins, agglutinin, viruses, and Sendai virus. These examples are not meant to be limiting and other fusion agents known in the art are applicable and included herein.

The term "suitable concentration" as used herein in reference to fusion agents, refers to any concentration of a fusion agent that affords a measurable amount of fusion. Fusion can be measured by multiple techniques well known to a person of ordinary skill in the art, such as by utilizing a light microscope, dyes, and fluorescent lipids, for example.

For the purposes ofthe present invention, the term "embryo" or "embryonic" as used herein refers to a developing cell mass that has not implanted into the uterine membrane of a maternal host. Hence, the term "embryo" as used herein can refer to a fertilized oocyte, a cybrid (defined herein), a pre-blastocyst stage developing cell mass, and/or any other developing cell mass that is at a stage of development prior to implantation into the uterine membrane of a maternal host. Embryos ofthe invention may not display a genital ridge. Hence, an "embryonic cell" is isolated from and/or has arisen from an embryo.

An embryo can represent multiple stages of cell development. For example, a one cell embryo can be referred to as a zygote, a solid spherical mass of cells resulting from a cleaved embryo can be referred to as a morula, and an embryo having a blastocoel can be referred to as a blastocyst.

In preferred embodiments (1) an embryo ofthe present invention is a mammalian embryo; (2) a mammalian embryo is selected from the group consisting of canid embryos, felid embryos, murid embryos, leporid embryos, ursid embryos, mustelid embryos, and human and non-human primate embryos; (3) a mammalian embryos is an ungulate embryo; and (4) an ungulate embryo is selected from the group consisting of suid embryos, ovid embryos, equid embryos, bovid embryos, caprid embryos, and cervid embryos.

The terms "fetus" and "fetal" as used herein refers to a developing cell mass that has implanted into the uterine membrane of a maternal host. A fetus can include such defining features as a genital ridge, for example. A genital ridge is a feature easily identified by a person of ordinary skill in the art, and is a recognizable feature in fetuses of most animal species. The term "fetal cell" as used herein can refer to any cell isolated from and/or has arisen from a fetus or derived from a fetus. The term "non-fetal cell" is a cell that is not derived or isolated from a fetus. In preferred embodiments (1) a fetus ofthe present invention is a mammalian fetus; (2) a mammalian fetus is selected from the group consisting of canid fetuses, felid fetuses, murid fetuses, leporid fetuses, ursid fetuses, mustelid fetuses, and human and non-human primate fetuses; (3) a mammalian fetus is an ungulate fetus; and (4) an ungulate fetus is selected from the group consisting of suid fetuses, ovid fetuses, equid fetuses, bovid fetuses, caprid fetuses, and cervid fetuses.

Additional embodiments relate to methods for preparing gene expression databases comprising two or more, and up to numbers of 10,000 or more, expressed sequence tags, the expression of which can be used to identify cells, embryos, or fetuses as being developmentally competent or developmentally incompetent.

In preferred embodiments, gene expression databases can be prepared by comparing one or more first nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to one or more second nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell, and identifying one or more nucleic acid molecules that are present in the population of first nucleic acid molecules, but that are not present at a detectable level in the population of second nucleic acid molecules, to provide two or more expressed sequence tags. ESTs (or their complementary sequences) so identified can then be combined in a gene expression database. Cells, embryos, and fetuses can be identified as developmentally competent based on the presence of at least one ofthe ESTs in such a gene expression database. In particularly preferred embodiments, a cell, embryo or fetus is identified as developmentally competent based on the presence of at least about 75% ofthe ESTs in such a gene expression database; at least about 90% ofthe ESTs in such a gene expression database; at least about 95% ofthe ESTs in such a gene expression database; and about 100% ofthe ESTs in such a gene expression database.

Similarly, in other preferred embodiments, gene expression databases can be prepared by comparing one or more first nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell to one or more second nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell, and identifying one or more nucleic acid molecules that are present in the population of first nucleic acid molecules, but that are not present at a detectable level in the population of second nucleic acid molecules, to provide two or more expressed sequence tags. ESTs (or their complementary sequences) so identified can then be combined in a gene expression database. Cells, embryos, and fetuses can be identified as developmentally incompetent based on the presence of at least one of the ESTs in such a gene expression database. In particularly preferred embodiments, a cell, embryo or fetus is identified as developmentally incompetent based on the presence of at least about 75% ofthe ESTs in such a gene expression database; at least about 90% ofthe ESTs in such a gene expression database; at least about 95% of the ESTs in such a gene expression database; and about 100% ofthe ESTs in such a gene expression database.

Most preferably, gene expression databases can be prepared by comparing one or more first nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to one or more second nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell, and identifying one or more ESTs that are present in the population of first nucleic acid molecules, but that are not present at a detectable level in the population of second nucleic acid molecules, and one or more ESTs that are present in the population of second nucleic acid molecules, but that are not present at a detectable level in the population of first nucleic acid molecules. ESTs (or their complementary sequences) so identified can then be combined in a gene expression database.

In particularly preferred embodiments, the comparing step comprises comparing one or more nucleic acid molecules to a reference nucleic acid library, preferably obtained from the same species as the source ofthe nucleic acid molecules. The term "nucleic acid library" as used herein refers to a collection of DNA molecules derived from and representing all or part ofthe genetic material of an organism, tissue, or cell. Examples of nucleic acid libraries are genomic libraries, which are derived from restriction fragments of a genome, and cDNA libraries, which are derived from the mRNA of an organism, tissue, or cell. In preferred embodiments, nucleic acid libraries can be developmentally specific, i.e., derived from a specific developmental stage, cell lineage specific, i.e., derived from a specific cell lineage, and/or tissue specific, i.e., derived from a specific tissue.

In yet other embodiments, the invention relates to methods for identifying a developmentally competent nuclear donor cell line, using the ESTs and gene expression databases ofthe invention.

These methods can comprise: performing one or more nuclear transfer procedures using cells(s) separated from a cell line to provide one or more nuclear transfer embryos; culturing each ofthe nuclear transfer embryos to at least two cells; separating at least one cell from each ofthe cultured embryos; determining the developmental competence of each ofthe separated embryonic cells by comparing one or more nucleic acid molecules from each embryonic cell to a gene expression database; and identifying those embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell.

The term "separating" as used herein refers to isolating one or more cells from a cell mass or cell culture. Cells can be separated by mechanical and chemical means well known to the skilled artisan. Cells can also be separated, for example, by biopsy or needle aspiration of a cell mass or cell culture. In this context, a "cell mass" can refer to an embryo, a fetus, or an animal.

The term "determining the developmental competence" with respect to embryos refers to identifying if an embryo is capable of developing into a live born animal. In certain embodiments, developmental competence is determined by implanting an embryo in a maternal host and allowing the embryo to develop until it either terminates or results in a live born animal. In certain other embodiments, developmental competence is determined by comparing the nucleic acid sequences present and/or expressed in one or more cells of an embryo to one or more nucleic acids that identify a cell as "developmentally competent" or "developmentally incompetent." Preferably, this determination is made using the ESTs and gene expression databases described herein. Cells obtained from an embryo can be used directly to determine the developmental competence ofthe source embryo, or the cells can be cultured prior to their use. In preferred embodiments, an embryo is determined to be developmentally competent based on the presence in one or more cells obtained from the embryo of one or more nucleic acid sequences that are known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence. As discussed herein, expression of nucleic acid sequences in a cell may be indirectly detected by detecting molecules produced from the nucleic acid sequences, such as proteins or peptides.

In other preferred embodiments, an embryo is determined to be developmentally incompetent based on the presence in a cell obtained from the embryo of one or more nucleic acid sequences that are that are present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent.

In yet other preferred embodiments, an embryo is determined to be developmentally competent based the presence in a cell obtained from the embryo of one or more nucleic acid sequences that are known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that are present and or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence; and the absence of one or more nucleic acid sequences that are that are present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent.

In additional preferred embodiments, an embryo is determined to be developmentally incompetent based the presence in a cell obtained from the embryo of one or more nucleic acid sequences that are that are present and/or expressed in a cell line that has been tested for, but has failed to demonstrate developmental competence, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be developmentally competent; and the absence of one or more nucleic acid sequences that are known to be present and/or expressed in a cell line that has been demonstrated to be developmentally competent, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate developmental competence.

In additional embodiments, the invention relates to methods for producing one or more embryos, fetuses, and/or animals by nuclear transfer procedures using a developmentally competent nuclear donor cell.

Methods for preparing embryos according to the invention preferably comprise: performing one or more nuclear transfer procedures using cells(s) separated from a cell line to provide one or more nuclear transfer embryos; culturing each ofthe nuclear transfer embryos to at least two cells; separating at least one cell from each of the cultured embryos; determining the developmental competence of each ofthe separated embryonic cells by comparing one or more nucleic acid molecules from each embryonic cell to a gene expression database; and identifying those embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell. Preferred methods for preparing fetuses and/or animals further comprise implanting the identified embryos into one or more recipient females for development into one or more fetuses and/or animals^'.

The term "culturing" as used herein in reference to embryos refers to laboratory procedures that involve placing an embryo in a culture medium. An embryo can be placed in a culture medium for an appropriate amount of time to allow stasis of an embryo, or to allow the embryo to grow in the medium. Culture media suitable for culturing embryos are well-known to those skilled in the art. See, e.g.,

Nagashima et al, 1997, Mol. Reprod. Dev. 48: 339-343; Petters & Wells, 1993, J. Reprod. Fert. (Suppl) 48: 61-73; Reed et al, 1992, Theriogenology 37: 95-109; Dobrinsky et al, 1996, Biol. Reprod. 55: 1069-1074; U.S. Patent No. 5,213,979, First et al, "In Vitro Culture of Bovine Embryos," May 25, 1993; U.S. Patent No. 5,096,822, Rosenkrans, Jr. et al., "Bovine Embryo Medium," March 17, 1992, each of which is incorporated herein by reference in its entirety, including all figures, tables, and drawings. Alternatively, an embryo may be "cultured in vivo," for example by placing the embryo into the ligated oviduct of a recipient female, for an appropriate amount of time to allow stasis of an embryo, or to allow the embryo to grow. Techniques of culturing an embryo in vivo are well known to those skilled in the art.

The term "suitable medium" as used herein refers to any medium that allows cell proliferation or allows stasis of an embryo. If a medium allows cell proliferation, a suitable medium need not promote maximum proliferation, only measurable cell proliferation. A suitable medium for embryo development can be an embryo culture medium described herein by example. Embryos ofthe invention can be cultured in media with or without feeder cells. In preferred embodiments, the feeder cells can be cumulus cells.

The terms "maternal recipient" and "recipient female" as used herein refers to a female animal which is implanted with an embryo for development ofthe embryo. A maternal recipient may be either homospecific or xenospecific to the implanted embryo. For example it has been shown in the art that bovine embryos can develop in the oviducts of sheep. Stice & Keefer, 1993, "Multiple generational bovine embryo cloning," Biology of Reproduction 48: 715-719. Implanting techniques are well known to_. a person of ordinary skill in the art. See, e.g., Polge & Day, 1982, "Embryo transplantation and preservation," Control of Pig Reproduction, DJA Cole and GR Foxcroft, eds., London, UK, Butterworths, pp. 227-291; Gordon, 1997, "Embryo transfer and associated techniques in pigs," Controlled reproduction in pigs (Gordon, ed), CAB International, Wallingford UK, pp 164-182; and Kojima, 1998, "Embryo transfer," Manual of pig embryo transfer procedures, National Livestock Breeding Center, Japanese Society for Development of Swine Technology, pp 76-79, each of which is incorporated herein by reference in its entirety, including all figures, tables, and drawings.

In preferred embodiments (1) an embryo, fetus, or animal ofthe present invention is a mammalian embryo, fetus, or animal; (2) a mammal is selected from the group consisting of canids, felids, murids, leporids, ursids, mustelids, and human and non-human primates; (3) a mammal is an ungulate; and (4) an ungulate is selected from the group consisting of suids, ovids, equids, bovids, caprids, and cervids. In particularly preferred embodiments, embryos, fetuses and/or animals ofthe invention are transgenic embryos, fetuses and/or animals. The term "transgenic" as used herein in reference to embryos, fetuses and animals refers to an embryo, fetus or animal comprising one or more cells whose genomes has been altered using recombinant DNA techniques. In preferred embodiments, a transgenic embryo, fetus, or animal comprises one or more transgenic cells. While germ line transmission is not a requirement of transgenic embryos, fetuses, or animals as that term is used herein, in particularly preferred embodiments a transgenic embryo, fetus, or animal can pass its transgenic characteristic(s) through the germ line. In certain embodiments, a transgenic embryo, fetus or animal expresses one or more exogenous genes as exogenous RNA and protein molecules. Most preferably, a transgenic embryo, fetus or animal results from a nuclear transfer procedure using a transgenic nuclear donor cell.

Additional embodiments relate to methods for assessing the effect of one or more changes to a nuclear transfer protocol by comparing the developmental competence of nuclear transfer embryos resulting from the changed protocol to the developmental competence of nuclear transfer embryos resulting from a baseline protocol, using the ESTs and expression databases ofthe invention

Preferably, changes in a nuclear transfer protocol are assessed by: performing one or more nuclear transfer procedures according to a first nuclear transfer protocol to produce one or more first protocol nuclear transfer embryos; performing one or more nuclear transfer procedures according to a second nuclear transfer protocol comprising one or more changes to said first nuclear transfer protocol, to produce one or more second protocol nuclear transfer embryos; determining the developmental competence of each of the first protocol and second protocol nuclear transfer embryos; and assessing the effect ofthe changes to the protocol by comparing the developmental competence ofthe first protocol nuclear transfer embryos to the developmental competence ofthe second protocol nuclear transfer embryos.

The term "assessing the effect of one or more changes in a nuclear transfer protocol" as used herein refers to the process of determining whether changing one or more variables in a nuclear transfer protocol alters the developmental competence of nuclear transfer embryos produced by the protocol. The skilled artisan will understand that the number of variables wliich may be changed are myriad, and can include changing the donor cell medium composition, the activation parameters, the fusion parameters, the embryo culture parameters, etc. By comparing the percentage of developmentally competent embryos produced by a baseline protocol to the percentage of developmentally competent embryos produced by the changed protocol, the effect ofthe changes can be determined. In preferred embodiments, the effect of the changes to the protocol is to increase the percentage of developmentally competent embryos produced. In certain embodiments, the effect ofthe changes to the protocol is to decrease the percentage of developmentally competent embryos produced.

The term "comparing the developmental competence" as used herein in reference to embryos refers to determining the percentage of developmentally competent embryos in two different group of embryos, and comparing the relative percentages in the two groups. The term "determining the developmental competence" of embryos is defined herein. In preferred embodiments, a group of embryos for comparison purposed comprise at least 2 embryos, at least 3 embryos, at least 4 embryos, at least 5 embryos, at least 6 embryos, at least 7 embryos, at least 8 embryos, at least 9 embryos, at least 10 embryos, at least 15 embryos, at least 20 embryos, at least 25 embryos, at least 30 embryos, at least 40 embryos, at least 50 embryos, at least 60 embryos, at least 70 embryos, at least 100 embryos, at least 200 embryos, at least 300 embryos, at least 400 embryos, and at least 500 embryos.

In further embodiments, the invention relates to nucleic acid arrays comprising the ESTs and gene expression libraries ofthe invention that can be used in methods, such as those described herein, to identify cells, embryos, or fetuses as being developmentally competent or developmentally incompetent.

The term "nucleic acid array" as used herein refers to one or more nucleic acid molecules affixed to a solid matrix. In certain embodiments, nucleic acid arrays can be used as solid supports for hybridization assays. Suitable solid matrices for attaching nucleic acids, and methods of attachment are well known in the art. See, e.g., U.S. Patent No. 6,004,755, issued on December 21, 1999 to B. Wang, entitled "Quantitative Microarray Hybridization Assays;" U.S. Patent No. 5,861,242, issued on January 19, 1999 to Chee et al, entitled "Array of Nucleic Acid Probes on Biological Chips for Diagnosis of HIV and Methods of Using the Same;" U.S. Patent No. 5,830,645, issued on November 3, 1998 to Pinkel et al, entitled "Comparative Fluorescence Hybridization to Nucleic Acid Arrays;" U.S. Patent No. 5,667,976, issued September 16, 1997 to VanNess et al, entitled "Solid Supports for Nucleic Acid Hybridization Assays;" and U.S. Patent No. 5,215,882, issued on June 1, 1993 to Bahl et al., entitled "Method of Immobilizing Nucleic Acid on a Solid Surface for Use in Nucleic Acid Hybridization Assays," each of which is incorporated in its entirety, including all tables, figures, and claims. In preferred embodiments, a solid phase can be papers, nitrocellulose membranes, nylon membranes, glass, magnetic materials, magnetic beads, polymeric beads, or silicon surfaces. In other preferred embodiments a solid phase can be a solid or semisolid polymer such as polyacrylamide gels and agarose gels.

Preferably, a nucleic acid array comprises at least one nucleic acid molecule, the expression of which (or its complementary sequence) identifies a cell as being developmentally competent or developmentally incompetent. More preferably, a nucleic acid array comprises from 2 to 10,000 or more nucleic acid molecules, the expression of which (or their complementary sequences) identifies a cell as being developmentally competent or developmentally incompetent. In particularly preferred embodiments, a nucleic acid array comprises at least one nucleic acid molecule, the expression of which (or its complementary sequence) identifies a cell as being developmentally competent, and at least one nucleic acid molecule, the expression of which (or its complementary sequence) identifies a cell as being developmentally incompetent.

In particularly preferred embodiments, a cell, embryo or fetus is identified as developmentally competent based on the presence of complementary sequences to at least about 75% ofthe ESTs comprised in such a nucleic acid array; at least about 90%) ofthe ESTs comprised in such a nucleic acid array; at least about 95% ofthe ESTs comprised in such a nucleic acid array; and about 100% ofthe ESTs comprised in such a nucleic acid array. In a second aspect, the invention concerns identifying and using one or more expressed sequence tags, the expression of which can be used to identify a cell, most ^■ preferably a stem cell, as being capable of committing to a specific cell lineage.

In certain embodiments, cells, and most preferably stem cells, can be , identified as being capable of committing to a specific cell lineage based on the expression of an expressed sequence tag (or its complementary sequence) known to be present and/or expressed in a cell line that has been demonstrated to be capable of committing to that cell lineage, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate such a capability. Similarly, cells can be identified as being incapable of committing to a specific cell lineage based on the expression of an expressed sequence tag (or its complementary sequence) known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate the capability of committing to the cell lineage, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be capable of committing to that cell lineage.

The term "stem cell" as used herein refers to one or more cells capable of differentiating into one or more different cell lineages. For example, hematopoetic stem cells can differentiate into one or more different blood cell types such as erythrocytes, platelets, macrophages, lymphocytes, etc. Such cells are pluripotent. Alternatively, some stem cells differentiate into a single cell lineage. For example, epidermal stem cells can differentiate into cornified epidermal cells. Such cells are unipotent. In particularly preferred embodiments, a stem cell is an embryonic stem cell.

The term "embryonic stem cell" as used herein refers to pluripotent cells isolated from an embryo that are maintained in in vitro cell culture. Embryonic stem cells may be, but need not be, totipotent. Embryonic stem cells may be cultured with or without feeder cells. Embryonic stem cells can be established from embryonic cells isolated from embryos at any stage of development, including blastocyst stage embryos and pre-blastocyst stage embryos. Embryonic stem cells may have a rounded cell morphology and may grow in rounded cell clumps on feeder layers. Embryonic stem cells are well known to a person of ordinary skill in the art. See, e.g., WO 97/37009, entitled "Cultured Inner Cell Mass Cell-Lines Derived from Ungulate Embryos," Stice and Golueke, published October 9, 1997, and Yang & Anderson, 1992, Theriogenology 38: 315-335, each of which is incorporated herein by reference in its entirety, including all figures, tables, and drawings. See, also, e.g., Piedrahita et al, 1998, Biol. Reprod. 58: 1321-1329; Wianny et al, 1997, Biol. Reprod. 57:

756-764; Moore & Piedrahita, 1997, In Vitro Cell Biol. Anim. 33: 62-71; Moore, & Piedrahita, 1996, Mol. Reprod. Dev. 45: 139-144; Wheeler, 1994, Reprod. Fert. Dev. 6: 563-568; Hochereau-de Reviers & Perreau, Reprod. Nutr. Dev. 33: 475-493; Strojek et al, 1990, Theriogenology 33: 901-903; Piedrahita et al, 1990, Theriogenology 34: 879-901; and Evans et al, 1990, Theriogenology 33: 125-129, each of which is incorporated herein by reference in its entirety, including all figures, tables, and drawings.

In preferred embodiments (1) a stem cell or a stem cell line ofthe present invention is a mammalian stem cell or stem cell line; (2) a mammalian stem cell or stem cell line is selected from the group consisting of canid stem cells or stem cell lines, felid stem cells or stem cell lines, murid stem cells or stem cell lines, leporid stem cells or stem cell lines, ursid stem cells or stem cell lines, mustelid stem cells or stem cell lines, and human and non-human primate stem cells or stem cell lines; (3) a mammalian stem cells or stem cell lines is an ungulate stem cells or stem cell lines; and (4) an ungulate stem cells or stem cell lines is selected from the group consisting of suid stem cells or stem cell lines, ovid stem cells or stem cell lines, equid stem cells or stem cell lines, bovid stem cells or stem cell lines, caprid stem cells or stem cell lines, and cervid stem cells or stem cell lines.

The term "differentiated" as used herein refers to a cell that has developed from an unspecialized phenotype to a specialized phenotype.

The term "undifferentiated cell" as used herein refers to a precursor cell that has an unspecialized phenotype and is capable of differentiating. An example of an undifferentiated cell is a stem cell.

The term "committing to a specific cell lineage" as used herein refers to the ability of a cell to differentiate into a specific cell type. For example, a hematopoetic stem cell may be capable of committing to an erythrocyte, platelet, macrophage, lymphocyte, etc., lineage, while an embryonic stem cell may be capable of committing to a wider variety of cell lineages, such as a muscular, neuronal, hematopoetic, osteal, germinal, etc., cell lineage. A cell, and in particular a stem cell, may be capable of committing to certain cell lineages, yet incapable of committing to others. A cell may only commit to a specific cell lineage when exposed to a proper differentiation-inducing stimulus.

As discussed above, the term "identifies" or "identifying" as used herein with respect to cells refers to the ability to distinguish between cells having two distinct characteristics. In preferred embodiments, a cell or cell line that is capable of committing to a specific cell lineage can be distinguished from that is not capable of committing to that lineage. In certain preferred embodiments, an EST or ESTs identify a cell or cell line as "capable of committing to a specific cell lineage" if the EST sequences are present and/or expressed in stem cells known to be capable of committing to that lineage, but are present and/or expressed at a reduced or nondetectable level in stem cells that have been tested for, but have failed to demonstrate the ability to commit to that lineage. Similarly, an EST or ESTs identify a cell or cell line as "incapable of committing to a specific cell lineage" if the sequences are present and/or expressed in embryos in stem cells that have been tested for, but have failed to demonstrate the ability to commit to that lineage, but are present and/or expressed at a reduced or nondetectable level in known to be capable of committing to that lineage.

In additional embodiments, expressed sequence tags can be grouped in numbers of 2 or more, and up to numbers of 10,000 or more, to provide a gene expression database. The expression of one or more expressed sequence tags in the database can be used to identify cells, most preferably stem cells, capable of committing to a specific cell lineage.

Preferably, a gene expression database comprises two or more expressed sequence tags (or their complementary sequences) known to be present and/or expressed in a cell line that has been demonstrated to be capable of committing to a specific cell lineage, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate such a capability. Cells can be identified as capable of committing to a specific cell lineage based on the presence of at least one ofthe ESTs in such a gene expression database. In particularly preferred embodiments, cells can be identified as capable of committing to a specific cell lineage based on the presence of at least about 75%> of the ESTs in such a gene expression database; at least about 90% ofthe ESTs in such a gene expression database; at least about 95% ofthe ESTs in such a gene expression database; and about 100% ofthe ESTs in such a gene expression database.

Likewise, a gene expression database preferably comprises two or more expressed sequence tags (or their complementary sequences) known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate the capability of committing to a specific cell lineage, but that are present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be capable of committing to that cell lineage. Cells can be identified as incapable of committing to a specific cell lineage based on the presence of at least one ofthe ESTs in such a gene expression database. In particularly preferred embodiments, cells can be identified as incapable of committing to a specific cell lineage based on the presence of at least about 75% ofthe ESTs in such a gene expression database; at least about 90% ofthe ESTs in such a gene expression database; at least about 95% of the ESTs in such a gene expression database; and about 100% ofthe ESTs in such a gene expression database.

Most preferably, a gene expression database comprises at least one EST (or its complementary sequence) known to be present and/or expressed in a cell line that has been demonstrated to be capable of committing to a specific cell lineage, but that is present and or expressed at a reduced or nondetectable level in a cell line that has been tested for, but has failed to demonstrate such a capability; and at least one EST

(or its complementary sequence) known to be present and/or expressed in a cell line that has been tested for, but has failed to demonstrate the capability of committing to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in a cell line that has been demonstrated to be capable of committing to that cell lineage. In such embodiments, cells can be identified as capable of committing to a specific cell lineage based on the presence on the presence of at least one ofthe former ESTs, and the absence ofthe latter ESTs. Likewise, cells can be identified as incapable of committing to a specific cell lineage based on the presence of at least one ofthe latter ESTs, and the absence ofthe former ESTs.

In further embodiments, the invention concerns methods for identifying one or more expressed sequence tags, the expression of which can be used to identify cells, most preferably stem cells, capable of committing to a specific cell lineage.

In preferred embodiments, one or more ESTs are identified by comparing one or more first nucleic acid molecules obtained from one or more cell lines that have been demonstrated to be capable of committing to a specific cell lineage to one or more second nucleic acid molecules obtained from one or more cell lines that have been tested for, but have failed to demonstrate such a capability. ESTs that signal the capability to commit to a specific cell lineage are identified as one or more nucleic acid molecules that are present in the population of first nucleic acid molecules, but that are not present at a detectable level in the population of second nucleic acid molecules. Likewise, one or more nucleic acid molecules that are present in the population of second nucleic acid molecules, but that are not present at a detectable level in the population of first nucleic acid molecules are identified as ESTs that signal the incapability to commit to a specific cell lineage.

In particularly preferred embodiments, an EST that signals the capability to commit to a specific cell lineage is a nucleic acid molecule (1) present and/or expressed in at least about 75% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 75% of cell lines that have been tested for, but have failed to demonstrate such a capability; (2) present and/or expressed in at least about 90% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 90% of cell lines that have been tested for, but have failed to demonstrate such a capability; (3) present and/or expressed in at least about 95% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 95% of cell lines that have been tested for, but have failed to demonstrate such a capability; and (4) present and/or expressed in at least about 100% of cell lines that have been demonstrated to be capable of cornmitting to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 100% of cell lines that have been tested for, but have failed to demonstrate such a capability.

In other particularly preferred embodiments, an EST that signals the incapability to commit to a specific cell lineage is a nucleic acid molecule (1) present and/or expressed in at least about 75% of cell lines that have been tested for, but have failed to demonstrate the ability to commit to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 75% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage; (2) present and/or expressed in at least about 90% of cell lines that have been tested for, but have failed to demonstrate the ability to commit to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 90% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage; (3) present and/or expressed in at least about 95% of cell lines that have been tested for, but have failed to demonstrate the ability to commit to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 95% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage; and (4) present and/or expressed in at least about 100% of cell lines that have been tested for, but have failed to demonstrate the ability to commit to a specific cell lineage, but that is present and/or expressed at a reduced or nondetectable level in at least about 100% of cell lines that have been demonstrated to be capable of committing to a specific cell lineage.

In another aspect, the invention concerns methods that identify one or more molecules that affect the developmental competence of cells, cell lines, embryos, fetuses, and/or animals.

In certain embodiments, molecules can be identified that induce developmental competence in an otherwise developmentally incompetent cell line. Similarly, molecules can be identified that induce developmental incompetence in an otherwise developmentally competent cell line. Such molecules can be used to increase the availability of developmentally competent cells for use as nuclear donor cells in nuclear transfer procedures, for the treatment of certain diseases, or for preventing full term pregnancies.

In preferred embodiments, molecules that induce developmental competence in an otherwise developmentally incompetent cell line can be identified by: contacting a developmentally incompetent cell line with one or more molecules to provide a treated cell line; separating one or more cells from the treated cell line to provide one or more separated cells; performing one or more nuclear transfer procedures using one or more separated cells to provide one or more nuclear transfer embryos; and determining the developmental competence of each ofthe nuclear transfer embryos. In particularly preferred embodiments, developmental competence is determined by comparing a plurality of nucleic acid molecules obtained from each ofthe embryos to a gene expression database ofthe instant invention.

Likewise, molecules that induce developmental incompetence in an otherwise developmentally competent cell line can be identified by: contacting a developmentally competent cell line with one or more molecules to provide a treated cell line; separating one or more cells from the treated cell line to provide one or more separated cells; performing one or more nuclear transfer procedures using one or more separated cells to provide one or more nuclear transfer embryos; and determining the developmental competence of each ofthe nuclear transfer embryos. In particularly preferred embodiments, developmental competence is determined by comparing a plurality of nucleic acid molecules obtained from each ofthe embryos to a gene expression database ofthe instant invention.

The term "contacting" as used herein with respect to cells refers to bringing one or more cells together with one or more molecules, whether in an in vitro system (e.g., in a test tube or an ex vivo system) or an in vivo system. One or more cells may be removed from an organism for contacting with one or more molecules, and then the cells can be returned to the same or a different animal.

In further embodiments, one or more molecules identified as inducing or inhibiting developmental competence can be used to induce or inhibit developmental competence in cells, cell lines, embryos, fetuses, or animals, by administering one or more molecules so identified to cells, cell lines, embryos, fetuses, or animals. In particularly preferred embodiments, administering one or more molecules so identified can be used to treat diseases in an animal, embryo, or fetus, or to prevent a full term pregnancy.

The term "administering" as used herein refers to a method of contacting one or more molecules with the one or more cells, cell lines, embryos, fetuses, or animals.

In the case of embryos, fetuses, and animals, cells may be contacted with one or more molecules while within an embryo, fetus, or animal; or cells may be removed from the embryo, fetus, or animal, contacted with one or more molecules, and then returned to the same or a different embryo, fetus, or animal. The compound can be prepared using a carrier such as dimethyl sulfoxide (DMSO) in an aqueous solution or preparation.

The compounds may be administered to cells or tissues using a suitable buffered solution. Cells existing outside an organism can be maintained or grown in cell culture dishes. For cells harbored within an organism, many techniques exist in the art to administer compounds, including (but not limited to) oral, parenteral, dermal, ocular, subcutaneous, and rectal applications. For cells outside ofthe organism, multiple techniques exist in the art to administer the compounds, including (but not limited to) cell microinjection techniques, transformation techniques, and carrier techniques.

In particularly preferred embodiments, one or more molecules can be administered to one or more cultured or non-cultured embryonic cells, embryonic stem cells, inner cell mass cells, fetal cells, embryonic germ cells, somatic cells, adult cells, neurons, glial cells, muscle cells, bone marrow cells, stem cells, hepatocytes, renal cells, muscle cells, cardiac cells, epidermal cells, oocytes, fertilized oocytes, spermatocytes, nuclear transfer embryos, pancreatic cells, lymphocytes, tumor cells, malignant cells, teratoma cells, seminoma cells, carcinoma cells, lymphoma cells, glioblastoma cells, hepatocellular carcinoma cells, and hamartoma cells.

The term "pharmaceutically acceptable composition" refers to a preparation comprising one or more molecules. The composition is acceptable if it does not appreciably cause irritations to the organism administered the composition.

The term "suitable buffered solution" refers to an aqueous preparation of a molecule that comprises a salt that can control the pH ofthe solution at low concentrations. Because the salt exists at low concentrations, the salt preferably does not alter the function of cells.

In another aspect, the invention concerns methods that identify and use one or more molecules that induce lineage specific development in a cell line, most preferably a stem cell line.

In certain embodiments, molecules so identified can the be used to induce lineage-specific development in one or more cells, preferably stem cells or stem cell lines, that might otherwise be incapable of such development.

In preferred embodiments, molecules that induce lineage specific development in a cell line are identified by: contacting a stem cell line known to be capable of differentiation into a specific cell type with one or more molecules to provide a treated cell line; and determining the capability ofthe treated cell line to differentiate into a specific cell type. In particularly preferred embodiments, the capability ofthe treated cell line to differentiate into the cell type of interest is determined by comparing a plurality of nucleic acid molecules obtained from one or more treated cells to a gene expression database ofthe instant invention.

The summary ofthe invention described above is not limiting and other features and advantages ofthe invention will be apparent from the following detailed description ofthe preferred embodiments, as well as from the claims.

BRIEF DESCRIPTION OF THE TABLES

Tables 1 A and B illustrates data concerning the developmental competence of 59 different nuclear donor cell lines.

Table 2 illustrates EST sequences screened for differential expression in developmentally competent bovine embryos versus developmentally incompetent bovine embryos. BRIEF DESCRIPTION OF THE FIGURES Figure 1 illustrates comparisons of EG+ and ES- donor cell expression profiles, determined using cDNA microarray, differential display, and direct sequencing methods. Figure 2 illusfrates immunoblot analysis of cultured EG+ and ES- donor cells.

Figure 3 illustrates examples of differential display analyses comparing mRNA expression patterns in individual embryos prepared in vivo, or by nuclear fransfer using EG+ and ES- donor cells.

Figure 4 A illustrates differential display analysis comapring banding patterns of 5 individual in vivo embryos, 6 individual IVF embryos, 5 individual NT embryos and the donor cell line (DC) used to reconstruct NT embryos. Arrows indicate bands present in all in vivo and at least 5 of 6 IVF produced embryos. Figure 4B shows a histogram indicating the percentage of bands shared with in vivo embryos.

Figure 5 illustrates identical cDNA arrays probed with mRNA representations of a single NT embryo (A) and a single in vivo embryo (B). Spots enclosed by circles represent clones detected at high levels in a single in vivo embryo and a single NT embryo reconstructed using a competent donor cell line, but at low levels (or undetected) in single NT embryos reconstructed from incompetent donor cell lines and an unknown cell line. Figure 6 illustrates a profile ofthe cDNA clones used for microarray analysis.

Figure 7 illustrates cluster analysis performed on individual embryos prepared by nuclear transfer using developmentally competent and incompetent donor cell lines, and embryos prepared by nuclear transfer using donor cells obtained from a cell line of unknown developmental competence.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to materials and methods for evaluating and affecting the molecular events associated with cellular differentiation and reprogramming, and, in particular, for evaluating and affecting molecular events related to developmental competence and lineage-specific development. The invention provides numerous advantages over methods currently in use. For example, the methods described herein can dramatically increase the number of developmentally competent nuclear donor cells, oocytes, and embryos available. The methods described herein can also dramatically increase the efficiency of nuclear fransfer procedures by identifying those nuclear donor cells, oocytes, and embryos most likely to result in successful live births, resulting in an increase in the number of viable embryos, fetuses, and live births, including transgenic embryos, fetuses, and animals. Moreover, the methods described herein can also dramatically increase the efficiency of nuclear transfer procedures by identifying techniques, such as oocyte and embryo maturation, oocyte activation, oocyte enucleation, timing of implantation, and maternal care most likely to result in successful live births.

As discussed herein, embryos produced by the methods described herein can be used in recloning procedures. Recloned embryos produced by such methods can exhibit enhanced developmental competence compared to embryos produced by a single round of nuclear transfer. In addition, recloning can enhance the efficiency of preparing transgenic embryos, fetuses and/or animals using gene targeting methods. Similarly, fetal cells (e.g., primordial germ cells) can be used as nuclear donor cells in multiple rounds of nuclear transfer for gene targeting methods. Following one or more rounds of nuclear fransfer and genetic manipulation, cells obtained from the resulting embryos, fetuses, or animals exhibiting a gene targeting event (such as a knockout or a gene replacement) may be particularly useful as cell-based therapeutics.

Moreover, the materials and methods described herein can increase the efficiency at which cells, and particularly stem cells, can be induced to differentiate into a specific cell lineage. Particularly when coupled with the ability to perform gene targeting with increased efficiency, the instant methods can greatly foster development of cell-based therapeutics.

I. Obtaining and Using Tissue-Specific and Developmentally-Specific Marker Genes and Sequences

The instant invention describes methods to evaluate molecular events associated with cellular reprogramming and differentiation. The tissue-specific and developmentally-specific marker molecules described by the instant invention can be any molecules that are expressed differentially as cells undergo reprogramming to a developmentally competent state, or as cells commit to a specific differentiation pathway. Preferably, such marker molecules are nucleic acid molecules, such as mRNAs, or cDNAs obtained therefrom; however, downstream products of these nucleic acids, such as proteins resulting from translation of mRNAs, or products produced by those proteins, can also be associated with cellular reprogramming and differentiation by techniques well known to the skilled artisan.

A. Expressed Sequence Tags

Methods for identifying and isolating expressed sequence tags are well known to the ordinarily skilled artisan. mRNAs, or cDNAs prepared therefrom, are preferred as a source of expressed sequence tags, as these molecules represent the expressed subset of genomic nucleic acid sequences. Preferably, full length or partial length cDNA clones can be prepared from one or more cells, embryos, fetuses, tissues, or animals by methods such as those described in Sambrook, et al, 1989, Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Press, Plainview, NY; and Innis, et al, 1990, PCR Protocols: A Guide To Methods And Applications, Academic Press, San Diego, CA. If necessary, RNA molecules that are present in only low abundance can be amplified by methods well known to those of skill in the art. See, e.g., mnis, et al, 1990.

B. Identifying Differentially Expressed Nucleic Acid Molecules

Tissue-specific and developmentally-specific nucleic acid molecules can be identified by comparing the mRNA or cDNA populations obtained from cells in two different differentiation or developmental states. Numerous methods are known to the skilled artisan for identifying commonly expressed and differentially expressed nucleic acid molecules. For example, northern analysis, nucleic acid sequencing, and SI nuclease protection assays can be used to quantitate relative gene expression levels. Preferably, relative copy numbers of target nucleic acids can be determined as described in U.S. Patent No. 5,830,645, issued to Pifrkel et al. on November 3, 1998, entitled "Comparative Fluorescence Hybridization to Nucleic Acid Arrays;" gene subtraction methods and differential display methods can identify sequences differeing in or common to two nucleic acid populations as described in U.S. Patent No. 5,436,142, issued to Wigler et al. on July 25, 1995, entitled "Methods for Producing Probes Capable of Distingushing Variant Genomic Sequences," Liang and

Pardee, 1991, Meth. Mol. Biol. 85: 3-11; and U.S. Patent No. 5,935,788, issued to Burmer et al. on August 10, 1999, entitled "Subfractive Hybridization Techniques for

Identifying Differentially Expressed and Commonly Expressed Nucleic Acid;" and differential display PCR or RT-PCR can identify sequences differeing in or common to two nucleic acid populations as described in U.S. Patent 5,773,213, issued to Gullans et al on June 30, 1998, entitled "Method for Conducting Sequential Nucleic

Acid Hybridization Techniques." Each ofthe references cited in this section are hereby incorporated by reference in their entirety, including all figures, tables, and claims.

C. Hybridization Supports

Nucleic acid hybridization techniques, such as those described herein, can be performed by methods that are well known to the ordinarily skilled artisan. See, e.g., Sambrook,. et al., 1989, Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Press, Plainview, NY; and U.S. Patent No. 5,215,882, issued to Bahl et al. on June 1, 1993, entitled "Method of Immobilizing Nucleic Acid on a Solid Surface For Use In Nucleic Acid Hybridization Assays." These methods can typically rely on affixing a test nucleic acid on a solid surface, such as cellulose or nylon papers or membranes or glass slides, which acts as a support for the hybridization assay. Numerous hybridization supports are known in the art. Particularly preferred hybridization supports are polymer beads and dipsticks, such as those described in U.S. Patent No. 5,667,976, issued to Van Ness et al. on September

16, 1997, entitled "Solid Supports for Nucleic Acid Hybridization Assays;" and nucleic acid arrays, macroarrays, and microarrays, such as those described in U.S. Patent No. 5,861,242, issued to Chee et al. on January 19, 1999, entitled "Array of Nucleic Acid Probes on Biolological Chips For Diagnosis of HIV and Methods of Using Same;" and U.S. Patent No. 6,004,755, issued to Wang on December 21, 1999, entitled "Quantitative Microarray Hybridization Assays." Each ofthe references cited in this section are hereby incorporated by reference in their entirety, including all figures, tables, and claims. D. Correlating Differentially Expressed Nucleic Acid Molecules to Cellular Reprogramming

The expression patterns of tissue-specific and developmentally-specific marker molecules can be analyzed to determine their correlation to characteristics such as developmental competence or incompetence, or to the ability to differentiate along a given lineage, using ^"techniques well known to the skilled artisan. For example, Pearson correlation, as described in Golub et al, 1999, Science 286: 531-7; hierarchical clustering as described in (Iyer et. al., '99) ; and Euclidian distance analysis as described in Golub et al, 1999, Science 286: 531-7 can be used to predict which marker molecules are most closely related to a given characteristic.

Preferably, neighbor analysis as described in Golub et al, 1999, Science 286: 531-7, can be used to identify an idealized expression pattern that predicts a given characteristic. In this method, differences between classes relative to the standard deviation with each class are considered. Each gene or EST is represented by an expression vector e_g=(e_gl, e_g2, e_g3,...,e_gs), where e_g; denotes the log expression level of gene g in the i^th sample, for a total of s samples on two classes. The statistic P(g_>c)=[μι(g) - μ2(g)]/[σ₁(g) + σ₂(g)], where μ_k(g) and σ_k(g) denote the mean and standard deviation ofthe log expression levels of gene g across Sk samples in class k relates to the degree of correlation between a gene or EST and a given characteristic. Large values of (P(g,c)) indicate a strong correlation, while low values indicate a weak correlation, while the sign indicates in which class the gene or EST is more strongly expressed.

Finally, the observed correlations are examined by neighbor analysis to determine whether the density of genes correlated with a given characteristic is greater than would be predicted by chance.

E. Identifying Differentially Expressed Protein Markers

Tissue-specific and developmentally-specific nucleic acid molecules can be identified and characterized by various protein biochemistry techniques known to the skilled artisan, including immunoblotting, competitive or noncompetitive immunoassay, and immunoprecipitation, and by various nonimmunological methods such as analytical centrifugation, amino acid analysis, sequencing, 1- and 2- dimensional electrophoresis (including both native and denaturing conditions such as SDS-PAGE), chromatography, peptide mapping, nuclear magnetic resonance, electron crystallography, and X-ray crystallography. See generally, Deutscher, ed., 1990, Methods in Enzymology, Volume 182, Academic Press, San Diego, CA. Particularly preferred methods, comprised under the general heading of "proteomics," and including 2-dimensional electrophoresis coupled with mass spectroscopy, particularly MALDI-TOF mass spectroscopy, can provide insights into gene expression beyond the mRNA level, including posttranslational modifications that cannot be predicted based solely on a nucleic acid sequence. See, e.g., VanBogelen et al, 1999, Electrophoresis 20: 2149-59; Hatzimanikatis et al, 1999, Biotech. Prog.

15: 312-8; and Blackstock and Weir, 1999, Trends Biotech. 17: 121-7

II. Nuclear Transfer Procedures

Nuclear fransfer procedures, i.e., methods in which a full complement of nuclear DNA is introduced from one cell into a second, enucleated, cell are well known to a person of ordinary skill in the art. See, U.S. Patent No. 4,994,384 to

Prather et al, entitled "Multiplying Bovine Embryos," issued on February 19, 1991; U.S. Patent No. 5,057,420 to Massey, entitled "Bovine Nuclear Transplantation," issued on October 15, 1991; U.S. Patent No. 5,994,619, issued on November 30, 1999 to Stice et al, entitled "Production of Chimeric Bovine or Porcine Animals Using Cultured Inner Cell Mass Cells; U.K. Patents Nos. GB 2,318,578 GB 2,331,751, issued on January 19, 2000 to Campbell et al. and Wilmut et al, respectively, entitled "Quiescent Cell Populations For Nuclear Transfer"; and U.S. Patent No. 6,011,197 to Strelchenko et al, entitled "Method of Cloning Bovines Using Reprogrammed Non- Embryonic Bovine Cells," issued on January 4, 2000, each of which are hereby incorporated by reference in its entirety including all figures, tables and drawings.

A. Nuclear Donors

Nuclear donor material used to establish a mammalian nuclear fransfer embryo can be obtained from a variety of cell types, including cultured and non-cultured cells isolated from an embryo arising from the union of two gametes in vitro or in vivo; cultured and non-cultured pluripotent cells, such as embryonic stem cells (ES cells) arising from cultured embryonic cells (e.g., pre-blastocyst cells and inner cell mass cells); cultured and non-cultured cells arising from inner cell mass cells isolated from embryos; cultured and non-cultured pre-blastocyst cells; cultured and non-cultured fetal cells; cultured and non-cultured primordial germ cells; cultured and non-cultured germ cells (e.g., embryonic germ cells); cultured and non-cultured somatic cells isolated from an animal or fetus; cultured and non-cultured cumulus cells; cultured and non-cultured amniotic cells; cultured and non-cultured fetal fibroblast cells; cultured and non-cultured genital ridge cells; cultured and non-cultured differentiated cells; cultured and non-cultured cells in a synchronous population; cultured and non- cultured cells in an asynchronous population; cultured and non-cultured serum- starved cells; cultured and non-cultured permanent cells; and cultured and non- cultured totipotent cells.

Particularly preferred mammalian nuclear donor cells are canids, felids, murids, leporids, mustelids, ursids, human and non-human primates, ungulates, ovids, suids, equids, bovids, caprids, and cervids. While pluripotent nuclear donor cells can typically give rise to the cloned embryos ofthe invention, a totipotent nuclear donor cell is generally preferable. For nuclear fransfer techniques, a donor cell may be separated from a growing cell mass, isolated from a primary cell culture, and/or isolated from a cell line. An entire cell may be placed in the perivitelline space of a recipient oocyte or may be directly injected into a recipient oocyte by aspirating the nuclear donor into a needle or a Piezo drill, placing the needle/drill tip into a recipient oocyte, releasing the nuclear donor and removing the needle without significantly disrupting the plasma membrane ofthe oocyte. Also, a nucleus (e.g., a karyoplast) may be isolated from a nuclear donor and placed into the perivitelline space of a recipient oocyte or may be injected directly into a recipient oocyte, for example.

A variety of methods for culturing nuclear donor cells exist in the art. See, e.g., Culture of Animal Cells: a manual of basic techniques (3rd edition), 1994, Freshney (ed.), Wiley-Liss, Inc.; Cells: a laboratory manual (vol. 1), 1998), Spector, Goldman, Leinwand (eds.), Cold Spring Harbor Laboratory Press; and Animal Cells: culture and media, 1994, Darling & Morgan, John Wiley and Sons, Ltd., each of which is incorporated herein by reference in its entirety including all figures, tables, and drawings. B. Transgenic Nuclear Donor Cells

Materials and methods readily available to a person of ordinary skill in the art can be utilized to convert the nuclear donor cells ofthe invention (e.g., amniotic cells and follicular cells) into transgenic cells. Once nuclear DNA is modified in a nuclear donor cell, embryos, fetuses, and animals arising from these cells can also comprise the modified nuclear DNA. Hence, materials and methods readily available to a person of ordinary skill in the art can be applied to nuclear donor cells to produce transgenic cloned and chimeric animals. See, e.g., EPO 264 166, entitled "Transgenic Animals Secreting Desired Proteins Into Milk"; WO 94/19935, entitled "Isolation of Components of Interest From Milk"; WO 93/22432, entitled "Method for Identifying

Transgenic Pre-implantation Embryos"; WO 95/17085, entitled "Transgenic Production of Antibodies in Milk;" Hammer et al, 1985, Nature 315: 680-685; Miller et al, 1986, J. Endocrinology 120: 481-488; Williams et al, 1992, J. Ani. Sci. 70: 2207-2111; Piedrahita et al, 1998, Biol. Reprod. 58: 1321-1329; Piedrahita et al, 1997, J. Reprod. Fert. (suppl.) 52: 245-254; and Nottle et al, 1997, J. Reprod. Fert.

(suppl.) 52: 245-254, each of which is incorporated herein by reference in its entirety including all figures, drawings and tables.

Methods for generating transgenic cells typically include (1) assembling a suitable DNA construct useful for inserting a specific DNA sequence into nuclear DNA of a cell; (2) transfecting the DNA sequence into cells; (3) allowing random insertion and/or homologous recombination to occur. A modification resulting from such a process may include insertion of a suitable DNA construct(s) into a target genome; deletion of DNA from a target genome; and/or mutation of a target genome.

DNA constructs can comprise a gene of interest as well as a variety of elements including regulatory promoters, insulators, enhancers, and repressors as well as elements for ribosomal binding to RNA transcribed from a DNA construct. DNA constructs can also encode ribozymes and anti-sense DNA and/or RNA. Moreover, DNA constructs can comprise a selection element, such as a gene for drug selection of transformants. These examples are well known to a person of ordinary skill in the art and are not meant to be limiting. Due to effective recombinant DNA techniques available in conjunction with DNA sequences for regulatory elements and genes readily available in data bases and the commercial sector, a person of ordinary skill in the art can readily generate a DNA construct appropriate for establishing transgenic cells using materials and methods described herein. For example, transfection techniques are well known to a person of ordinary skill in the art and materials and methods for carrying out transfection of DNA constructs into cells are commercially available. For example, materials that can be used to transfect cells with DNA constructs are lipophillic compounds, such as Lipofectin™, Superfect™, LipoTAXI™, and CLONfectin™. Particular lipophillic compounds can be induced to form liposomes for mediating transfection ofthe DNA construct into the cells. In addition, cationic based transfection agents that are known in the art can be utilized to transfect cells with nucleic acid molecules (e.g., calcium phosphate precipitation, DEAE-dextran, polybrene, polyamine). Other techniques are known in the art that use protein-based or amphipafhic polyamines as transfection reagents. Also, electroporation techniques known in the art can be utilized to translocate nucleic acid molecules into cells. Furthermore, particle bombardment techniques known in the art can be utilized to introduce exogenous DNA into cells. Target sequences from a DNA construct can be inserted into specific regions of nuclear DNA by rational design of a DNA construct. Such design techniques and methods are well known to a person of ordinary skill in the art. See, U.S. Patent

5,633,067, "Method of Producing a Transgenic Bovine or Transgenic Bovine Embryo," DeBoer et al, issued May 27, 1997; U.S. Patent 5,612,205, "Homologous Recombination in Mammalian Cells," Kay et al, issued March 18, 1997; and PCT publication WO 93/22432, "Method for Identifying Transgenic Pre-Implantation Embryos," each of which is incoφorated herein by reference in its entirety, including all figures, drawings, and tables. Once a desired DNA sequence is inserted into the nuclear DNA of a cell, the location of an insertion region as well as the frequency with which the desired DNA sequence has inserted into the nuclear genome can be identified by methods well known to those skilled in the art.

Once a transgene or transgenes are inserted into nuclear DNA of a nuclear donor cell, that cell can be used for cloning a transgenic animal. A description of embodiments related to transgenic animals are described in further detail hereafter. i. Diseases and Parasites

Desired DNA sequences can be inserted into nuclear DNA of a cell to enhance the resistance of a cloned transgenic animal to particular parasites, diseases, and infectious agents. Examples of parasites include worms, flies, ticks, and fleas. Examples of infectious agents include bacteria, fungi, and viruses. Examples of diseases include Afrophic rhinitis, Cholera, Leptospirosis, Pseudorabies, Pasturellosis, and Brucellosis. These examples are not limiting and the invention relates to any disease or parasite or infectious agent known in the art. See, e.g., Hagan & Bruners Infectious Diesases of Domestic Animals (7th edition), Gillespie & Timoney, copyright 1981, Cornell University Press, Ithaca NY.

A transgene can confer resistance to a particular parasite or disease by completely abrogating or partially alleviating symptoms ofthe disease or parasitic condition, or by producing a protein which controls the parasite or disease.

ii. Elements of DNA Constructs and Production of DNA Constructs

A wide variety of transcriptional and franslational regulatory sequences may be inserted into nuclear DNA of a nuclear donor cell. Transcriptional and franslational regulatory signals may be derived from viral sources, such as adenovirus, bovine papilloma virus, cytomegalovirus, simian virus, or the like, whereas the regulatory signals can be associated with a particular gene sequence having a potential for high levels of expression. Additionally, promoters from mammalian expression products, such as actin, casein, alpha-lactalbumin, uroplakin, collagen, myosin, and the like, may be employed. Transcriptional regulatory signals may be selected which allow for repression or activation, so that expression of a gene product can be modulated. Of interest are regulatory signals which can be repressed or initiated by external factors such as chemicals or drugs. These examples are not limiting and the invention relates to any regulatory elements. Other examples of regulatory elements are described herein.

iii. Examples of Preferred Recombinant Products A variety of proteins and polypeptides can be encoded by a gene harbored within a DNA construct suitable for creating transgenic cells. Those proteins or polypeptides include hormones, growth factors, enzymes, clotting factors, apolipoproteins, receptors, drugs, pharmaceuticals, bioceuticals, nutraceuticals, oncogenes, tumor antigens, tumor suppressors, cytokines, viral antigens, parasitic antigens, bacterial antigens and chemically synthesized polymers and polymers biosynthesized and/or modified by chemical, cellular and/or enzymatic processes. Specific examples of these compounds include proinsulin, insulin, growth hormone, androgen receptors, insulin-like growth factor I, insulin-like growth factor II, insulin growth factor binding proteins, epidermal growth factor, TGF-α, TGF-β, dermal growth factor, platelet derived growth factor (PDGF), angiogenesis factors (e.g., acidic fibroblast growth factor, basic fibroblast growth factor, and angiogenin), angiogenesis inhibitors (e.g., endostatin and angiostatin), matrix proteins (Type IV collagen, Type VII collagen, laminin), oncogenes (ras, fos, myc, erb, src, sis, jun), E6 or E7 transforming sequence, p53 protein, cytokine receptor, IL-1, IL-6, IL-8, IL-2, α, β, or γ IFN, GMCSF, GCSF, viral capsid protein, and proteins from viral, bacterial and parasitic organisms. Other specific proteins or polypeptides which can be expressed include: phenylalanine hydroxylase, α-1 -antitrypsin, cholesterol-7β- hydroxylase, truncated apolipoprotein B, lipoprotein lipase, apolipoprotein E, apolipo- protein Al , LDL receptor, scavenger receptor for oxidized lipoproteins, molecular variants of each, VEGF, and combinations thereof. Other examples are antibodies (monoclonal or polyclonal), antibody fragments, clotting factors, apolipoproteins, drugs, tumor antigens, viral antigens, parasitic antigens, monoclonal antibodies, and bacterial antigens. One skilled in the art readily appreciates that these proteins belong to a wide variety of classes of proteins, and that other proteins within these classes or outside of these classes can also be used. These are only examples and are not meant to be limiting in any way.

It should also be noted that the genetic material wliich is incoφorated into the cells from DNA constructs includes (1) nucleic acid sequences not normally present in target cells; (2) nucleic acid molecules which are normally present in target cells but not expressed at physiological significant levels; (3) nucleic acid sequences normally present in target cells and normally expressed at physiological desired levels; (4) other nucleic acid sequences which can be modified for expression in target cells; and (5) any combination ofthe above.

In addition, DNA constructs may become incoφorated into nuclear DNA of cells, where incoφorated DNA can be transcribed into ribonucleic acid molecules that can cleave other RNA molecules at specific regions. Ribonucleic acid molecules which can cleave RNA molecules are referred to in the art as ribozymes. Ribozymes are themselves RNA molecules. Ribozymes can bind to discrete regions on a RNA molecule, and then specifically cleave a region within that binding region or adjacent to the binding region. Ribozyme techniques can thereby decrease the amount of polypeptide translated from formerly intact message RNA molecules.

Furthermore, DNA constructs can be incoφorated into nuclear DNA of cells and when transcribed produce RNA that can bind to both specific RNA or DNA sequences. Nucleic acid sequences can be utilized in anti-sense techniques, where nucleic acids bind to a message (mRNA) in order to block translation. Anti-sense techniques can thereby block or partially block the synthesis of particular polypeptides in cells.

C. Recipient Cells

A recipient cell is a cell into which the nuclear donor is inserted. Preferably, the recipient cell is enucleated, i.e., the recipient cell nucleus chromosomal material is removed or inactivated. A recipient cell is preferably an oocyte with a portion of its ooplasm removed, where the removed ooplasm comprises the oocyte nucleus genetic material. Enucleation techniques are well known to a person of ordinary skill in the art, as described hereafter. Other recipient cells, e.g., a two cell enucleated embryo, are known to the ordinarily skilled artisan. A recipient cell can also be rendered "functionally enucleated," for example by ultraviolet irradiation. See, e.g., Bradshaw et al. (1995), Molecular Reproduction and Development 41:503-12.

i. Isolation of Oocytes

Oocytes can be isolated from oviducts and/or ovaries of live animals by oviductal recovery procedures or fransvaginal oocyte recovery procedures well known in the art. Furthermore, oocytes can be isolated from deceased animals. For example, ovaries can be obtained from abattoirs and oocytes can be aspirated from these ovaries. Oocytes can also be isolated from ovaries of a recently sacrificed animal or when an ovary has been frozen and/or thawed. Oocytes may be isolated from ovarian follicles at any stage of development, including primordial follicles, primary follicles, secondary follicles, growing follicles, vesicular follicles, maturing follicles, mature follicles, and graafian follicles. Moreover, oocytes can be isolated from follicles which are obtained from animals, and which are grown and matured in culture. Materials and methods for isolating oocytes from various developmental stages of ovarian follicles are known to those skilled in the art. See, e.g., Laboratory Production of Cattle Embryos, 1994, Ian Gordon, CAB International; Anatomy and Physiology of Farm Animals (5th ed.), 1992, R.D. Frandson and T.L. Spurgeon, Lea & Febiger, each of wliich is incoφorated herein by reference in its entirety including all figures, drawings, and tables.

In preferred embodiments, the recipient oocyte is a mammalian oocyte.

Particularly preferred are canid, felid, murid, leporid, mustelid, human and nonhuman primate, ungulate, ovid, suid, equid, bovid, caprid, and cervid recipient oocytes. A nuclear donor cell and a recipient oocyte may be isolated from an animal ofthe same species or different species. For example, a porcine cumulus cell can be inserted into a porcine enucleated oocyte. Alternatively, a wild boar cumulus cell can be inserted into a domesticated porcine oocyte. Any nuclear donor/recipient oocyte combinations are envisioned by the invention. Preferably a nuclear donor and recipient oocyte are isolated from the same species. Xenospecific NT techniques can be utilized to produce cloned animals that are endangered or extinct.

Oocytes can be activated by electrical and/or non-electrical means before, during, and/or after a nuclear donor is infroduced to recipient oocyte. For example, an oocyte can be placed in a medium containing one or more components suitable for non-electrical activation prior to fusion with a nuclear donor. Also, a cybrid can be placed in a medium containing one or more components suitable for non-electrical activation. Activation processes are discussed in greater detail hereafter. ii. Oocyte Maturation

Oocytes and cumulus cell/oocyte complexes can be matured in vivo, and more preferably, can be matured in an in vitro environment. The length of time oocytes is matured can vary, depending upon species. In preferred embodiments, oocytes can be matured for (1) greater than about 10 hours; (2) greater than about 20 hours; (3) greater than about 24 hours; (4) greater than about 30 hours; (5) greater than about 40 hours; (6) greater than about 50 hours; (7) greater than about 60 hours (8) greater than about 72 hours; (9) greater than about 80 hours; (10) greater than about 90 hours; and (11) greater than about 100 hours. The term "about" with respect to oocyte maturation refers to plus or minus 5 hours.

A variety of media well known to a person of ordinary skill in the art can be used for maturing oocytes in vitro. See, e.g., (i) Aim & Hinrichs, 1996, J. Reprod. Fert. 107: 215-220 and Aim & Tomer, 1994, Theriogenology 42: 345-349 for equine oocytes; (ii) ; Ledda et al, 1991, Journal of Reproduction and Fertility 109:73-78; Byrd et al, 1997, Theriogenology 47: 857-864; Wilmut et al, 1997, Nature 385:

810-813; and LeGal, 1996, Theriogenology 45: 1177-1 for caprine and ovine oocytes; (iii) ; Lorenzo et al., 1996, Journal of Reproduction and Fertility 107:109-117 and Jelinkova et al, 1994, Molecular Reproduction and Development 37:210-215 for leporidine oocytes; (iv) Nickson et al, 1993, J. Reprod. Fert. (Suppl. 47): 231-240; Yamada et al, 1993, J. Reprod. Fert. (Suppl. 47): 227-229; and Mahi &Yanagimachi,

1976, Journal of Experimental Zoology 196; 189-196 for canine oocytes; (v) Fukui et al, 1991, Theriogenology 35: 499-512 and Pollard et al, 1995, Theriogenology 43: 301 for cervidine oocytes; and (vi) Del Campo et al, 1995, Theriogenology 43: 21-30 and Del Campo et al, 1994, Theriogenology 41: 187 for camelid oocytes. One example of such a medium suitable for maturing oocytes in vitro is depicted in an exemplary embodiment described herein. Oocytes can be successfully matured in such a medium within an environment comprising 5% CO₂ at 39°C. Oocytes may be cryopreserved and then thawed before placing the oocytes in maturation medium. Cryopreservation procedures for cells and embryos are well known in the art as discussed herein. Components of an oocyte maturation medium can include molecules that arrest oocyte maturation. Examples of such components are 6-dimethylaminopurine (DMAP) and isobutylmethylxanthine (LBMX). LBMX has been reported to reversibly arrest oocytes, but the efficiencies of arrest maintenance are quite low. See, e.g., Rose-Hellkant and Bavister, 1996, Mol. Reprod. Develop. 44: 241-249. However, oocytes may be arrested at the germinal vesicle stage with a relatively high efficiency by incubating oocytes at 31 °C in an effective concentration of LBMX. Preferably, oocytes are incubated the entire time that oocytes are collected. Concentrations of LBMX suitable for oocyte maturation are 0.01 mM to 20 mM LBMX, preferably 0.05 mM to 10 mM LBMX, and more preferably about 0.1 mM LBMX to about 0.5 mM

LBMX, and most preferably 0.1 mM IBMX to 0.5 mM LBMX. The exemplary oocyte maturation procedures are not meant to be limiting and the invention relates to any oocyte maturation procedure known to a person of ordinary skill in the art.

D. Nuclear Transfer

A nuclear donor can be translocated into a nuclear acceptor, preferably an oocyte, most preferably an enucleated oocyte, using a variety of materials and methods that are well known to a person of ordinary skill in the art. In one example, a nuclear donor may be directly injected into a recipient oocyte. This direct injection can be accomplished by gently pulling a nuclear donor into a needle, piercing a recipient oocyte with that needle, releasing the nuclear donor into the oocyte, and removing the needle from the oocyte without significantly disrupting its membrane. Appropriate needles can be fashioned from glass capillary tubes, as defined in the art and specifically by publications incoφorated herein by reference.

In another example, at least a portion of plasma membrane from a nuclear donor and recipient oocyte can be fused together by utilizing techniques well known to a person of ordinary skill in the art. See, Willadsen, 1986, Nature 320:63-65, hereby incoφorated herein by reference in its entirety including all figures, tables, and drawings. Typically, lipid membranes can be fused together by electrical and chemical means, as defined previously and in other publications incoφorated herein by reference. Examples of non-electrical means of cell fusion involve incubating cybrids in solutions comprising polyethylene glycol (PEG), and/or Sendai virus. PEG molecules of a wide range of molecular weight can be utilized for cell fusion.

Processes for fusion that are not explicitly discussed herein can be determined without undue experimentation. For example, modifications to cell fusion techniques can be monitored for their efficiency by viewing the degree of cell fusion under a microscope. The resulting cybrid can then be cloned and identified as totipotent by the methods described below for identifying totipotent cells, which can include tests for selectable markers and/or tests for developing an animal.

E. Activation

Examples of electrical processes for activation are well known in the art. Although electrical pulses are sometimes sufficient for stimulating cell activation, other non-electrical means for activation are useful and are often necessary for proper activation of a cell. Electrical and non-electrical activation may be used separately, or may be used together for activating a cell. Chemical materials and methods useful for non-electrical activation are described below in other preferred embodiments of he invention. When two or more chemical components are introduced to a cell for activating the cell, the components can be added simultaneously or individually in steps.

Examples of components that are useful for non-electrical activation include ethanol; inositol trisphosphate (IP3); divalent ions (e.g., addition of Ca2+ and/or Sr2+); microfilament inhibitors (e.g., cytochalasin B); ionophores for divalent ions (e.g., the Ca2+ ionophore ionomycin); protein kinase inhibitors (e.g., 6- dimethylaminopurine (DMAP)); protein synthesis inhibitors (e.g., cyclohexamide); phorbol esters such as phorbol 12-myristate 13 -acetate (PMA); and thapsigargin. It is also known that temperature change and mechanical techniques are also useful for non-electrical activation. The invention includes any activation techniques known in the art. See, e.g., U.S. Patent No. 5,496,720, entitled "Parthenogenic Oocyte Activation," issued on March 5, 1996, Susko-Parrish et al., and Wakayama et al, 1998, Nature 394: 369-374, each of which is incoφorated herein by reference in its entirety, including all figures, tables, and drawings. Examples of preferred protein kinase inhibitors are protein kinase A, G, and C inhibitors such as 6-dimethylaminopurine (DMAP), staurosporin, 2-aminopurine, sphingosine. Tyrosine kinase inhibitors may also be utilized to activate cells.

Preferred methods for activating cells are depicted in exemplary embodiments described herein. Activation materials and methods that are not explicitly discussed herein can be identified by modifying specified conditions defined in exemplary protocols described hereafter and in U.S. Patent No. 5,496,720.

Activation efficiency and totipotency that result from any modifications of activation procedures can be identified by methods described herein. Methods for identifying totipotent embryos can include one or more tests, such as (a) identifying specific markers for totipotent cells in embryos, and (b) by determining whether embryos are totipotent by allowing them to develop into an animal. Therefore, the invention relates to any modifications to activation procedures described herein even though these modifications may not be explicitly stated herein.

F. Manipulation of Embryos, Fetuses, and Animals Resulting from

Nuclear Transfer

i An embryo resulting from a NT process can be manipulated in a variety of manners. The invention relates to cloned embryos, fetuses, and animals that arise from at least one NT. Two or more NT procedures may be performed to enhance nuclear transfer efficiency of totipotent embryo, fetus, and animal production and/or placental development. Incoφorating two or more NT cycles into methods for cloned embryos, fetuses, and animals can provide further advantages. For example, incoφorating multiple NT procedures provides a method for multiplying the number of cloned embryos, fetuses, and animals. Moreover, gene targeting methods require that both copies of a given gene in a diploid cell be targeted in order to knock out or replace the gene. Such methods may require two or more NT procedures in order to efficiently target the gene. The skilled artisan will understand that the methods required for such manipulations will vary, depending on the species of interest.

When multiple T procedures are utilized for formation of a cloned embryo, fetus, or animal, oocytes that have been matured for any period of time can be utilized as recipients in the first, second or subsequent NT procedures. For example, if a first NT and then a second NT are performed, the first NT can utilize an oocyte that has been matured for about 53 hours as a recipient and the second NT may utilize an oocyte that has been matured for less than about 53 hours as a recipient. Alternatively, the first NT may utilize an oocyte that has been matured for about 53 hours as a recipient and the second NT may utilize an oocyte that has been matured for greater than about 53 hours as a recipient for a two-cycle NT regime. In addition, both NT cycles may utilize oocytes that have been matured for about 53 hours as recipients, both NT cycles may utilize oocytes that have been matured for less than about 53 hours as recipients, and both NT cycles may utilize oocytes that have been matured for greater than about 53 hours as recipients in a two-cycle NT regime.

For NT techniques that incoφorate two or more NT cycles, one or more ofthe NT cycles may be preceded, followed, and/or carried out simultaneously with an activation step. As defined previously herein, an activation step may be accomplished by electrical and/or non-electrical means as defined herein. An activation step may also be carried out at the same time as a NT cycle (e.g., simultaneously with the NT cycle) and/or an activation step may be carried out prior to a NT cycle. Cloned embryos resulting from a NT cycle can be (1) disaggregated or (2) allowed to develop further.

If embryos are disaggregated, the disaggregated embryonic derived cells can be utilized to establish cultured cells. Any type of embryonic cell can be utilized to establish cultured cells. These cultured cells are sometimes referred to as embryonic stem cells or embryonic stem-like cells in the scientific literature. Embryonic stem cells can be derived from early embryos, morulae, and blastocyst stage embryos. Multiple methods are known to a person of ordinary skill in the art for producing cultured embryonic cells. These methods are enumerated in specific references previously incoφorated by reference herein.

If embryos are allowed to develop into a fetus in utero, or a live-born animal, cells isolated from that fetus or animal can be utilized to establish cultured cells. In preferred embodiments, primordial germ cells, genital ridge cells, and fetal fibroblast cells can be isolated from a fetus. Similarly, a variety of somatic cells or germ cells can be isolated form a live-born animal. Such cultured cells can be established by utilizing culture methods well known to a person of ordinary skill in the art. Such methods are enumerated in publications previously incoφorated herein by reference and are discussed herein.

Cloned embryos resulting from NT can also be manipulated by cryopreserving and/or thawing such embryos. See, e.g., Nagashima et al, 1989, Japanese J. Anim. Reprod. 35: 130-134 and Feng et al, 1991, Theriogenology 35: 199, each of which is incoφorated herein by reference in its entirety including all tables, figures, and drawings. Other embryo manipulation methods include in vitro culture processes; performing embryo transfer into a maternal recipient; disaggregating blastomeres for

NT processes; disaggregating blastomeres or inner cell mass cells for establishing cell lines for use in NT procedures; embryo splitting procedures; embryo aggregating procedures; embryo sexing procedures; and embryo biopsying procedures. Exemplary manipulation procedures are not meant to be limiting and the invention relates to any embryo manipulation procedure known to a person of ordinary skill in the art.

G. Development of Cloned Embryos

i. Culture of Embryos In Vitro

Cloning procedures discussed herein provide an advantage of culturing cells and embryos in vitro prior to implantation into a recipient female. Methods for culturing embryos in vitro are described in detail herein. In addition, exemplary embodiments for media suitable for culturing cloned embryos in vitro are described hereafter. Feeder cell layers may or may not be utilized for culturing cloned embryos in vitro. Feeder cells are described previously and in exemplary embodiments hereafter.

ii. Development of Embryos In Vivo

Cloned embryos can be cultured in an artificial or natural uterine environment after NT procedures. Moreover, cloned embryos can be cultured in vivo prior to, subsequent to, or in the absence of culture ofthe embryo in vitro. Examples of artificial development environments are being developed and some are known to those skilled in the art. Components ofthe artificial environment can be modified, for example, by altering the amount of a component or components and by monitoring the growth rate of an embryo.

Methods for implanting embryos into the uterus of an animal are also well known in the art, as discussed previously. Preferably, developmental stage ofthe embryo(s) is correlated with the estrus cycle of an animal.

Embryos from one species can be placed into a uterine environment in an animal from another species. For example it has been shown in the art that bovine embryos can develop in oviducts of sheep. Stice & Keefer, 1993, "Multiple generational bovine embryo cloning," Biology of Reproduction 48: 715-719. The invention relates to any combination of an embryo in any homospecific or xenospecific uterine environment. A xenospecific in utero development regime can allow for efficient production of cloned animals of an endangered species. For example, a wild boar embryo can develop in the uterus of a domestic porcine sow.

Once an embryo is placed into the uterus of a recipient female, the embryo can develop to term. Alternatively, an embryo can be allowed to develop in the uterus and then can be removed at a chosen time. Surgical methods are well known in the art for removing fetuses from uteri before parturition.

III. Materials and Methods for Oocyte Maturation, Oocyte Enucleation, Cell Activation, In Vitro Embryo Development, and Other Processes

Where descriptions of oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes are described herein in relation to mammals in general, the following references provide additional descriptions of such process for specific mammals. The following references are provided to aid the reader in understanding the invention and are not admitted to describe or constitute prior art to the present invention. With regard to suids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Grocholova et al, 1997, J. Exp. Zoology 277: 49-56; Schoenbeck et al, 1993, Theriogenology 40: 257-266; Prafher et al.,1989, Biology of Reproduction 41: 414-418; Prather et al.,1991,

Molecular Reproduction and Development 28: 405-409; Jolliff & Prather, 1997, Biol. Reprod. 56: 544-548; Mattioli et al.,1991, Molecular Reproduction and Development 30: 109-125; Terlouw et al, 1992, Theriogenology 37: 309; Prochazka et al.,1992, J. Reprod. Fert. 96: 725-734; Funahashi et α/.,1993, Molecular Reproduction and Development 36: 361-367; Prather et al, Bio. Rep. Vol. 50 Sup 1: 282; Nussbaum et al., 1995, Molecular Reproduction and Development 41 : 70-75; Funahashi et al,

1995, Zygote 3: 273-281; Wang et al, 1997, Biology of Reproduction 56: 1376-1382; Piedrahita et α/.,1989, Biology of Reproduction 58: 1321-1329; Machaty et α/.,1997, Biology of Reproduction 57: 85-91; and Machaty et α/.,1995, Biology of Reproduction 52: 753-758.

With regard to bovids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., U.S. Patents 5,453,357 and 5,670,372, entitled "Pluripotent Embryonic Stem Cells and Methods of Making Same," Hogan; Sims & First, 1993, Theriogenology 39:313; Keefer et al, 1994, Mol. Reprod. Dev. 38:264- 268; U.S. Patent No. 4,994,384, "Multiplying Bovine Embryos," Prather et al; U.S.

Patent No. 5,057,420, "Bovine Nuclear Transplantation," Massey & Willadsen; Delhaise et al, 1995, Reprod. Fert. Develop. 7:1217-1219; Lavoir 1994, J. Reprod. Dev. 37:413-424; PCT application WO 95/10599 entitled "Embryonic Stem Cell-Like Cells"; Stice et al, 1996, Biol. Reprod. 54: 100-110; Sfrelchenko, 1996, Theriogenology 45: 130-141; WO 97/37009, entitled "Cultured Inner Cell Mass Cell-

Lines Derived from Ungulate Embryos," Stice and Golueke, published October 9, 1997; U.S. Patent No. 5,213,979, entitled "In vitro Culture of Bovine Embryos," First et al, May 25, 1993; U.S. Patent No. 5,096,822, entitled "Bovine Embryo Medium," Rosenkrans, Jr. et al, March 17, 1992; Seidel and Elsden, 1997, Embryo Transfer in Dairy Cattle, W.D. Hoard & Sons, Co., Hoards Dairyman; Stice & Keefer, 1993,

"Multiple generational bovine embryo cloning," Biology of Reproduction 48: 715- 719; Wagoner et al, 1996, "Functional enucleation of bovine oocytes: effects of centrifugation and ultraviolet light," Theriogenology 46: 279-284; Pieterse et al, 1988, "Aspiration of bovine oocytes during transvaginal ultrasound scanning ofthe ovaries," Theriogenology 30: 751-762; Saito et al, 1992, Roux's Arch. Dev. Biol.

201: 134-141; and U.S. Patent No. 5,496,720, entitled "Parthenogenic Oocyte Activation," March 5, 1996, Susko-Parrish et al.

61 With regard to felids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Swanson et al, 1996, Molecular Reprod. Dev. 43: 298-305; Donoghue et al, 1996, J. Reprod. and Fertility 107: 53-58; Goritz et al, 1996, J. Reprod. and Fertility 106: 117-124; Hoffert et al, 1997, Molecular Reprod.

Dev. 48: 208-215; Donoghue et al, 1990, Biology of Reprod. 43: 733-744; Wood et al, 1995, J. Reprod. Fertility 104: 315-323; Donoghue et al, 1992, Biology Reprod. 46: 972-980; Johnston et al, 1991, J. Reprod. Fert 92: 377-382; Luvoni et al, 1993, J. Reprod. Fert. Suppl. 47: 203-207; Roth et al, 1997, Biology of Reprod. 57: 165-171; and Jewgenow, 1996, Theriogenology 45: 889-895.

With regard to canids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Nickson et al, 1993, J. Reprod. Fert. (Suppl. 47): 231- 240; Yamada et al, 1993, J. Reprod. Fert. (Suppl. 47): 227-229; Mahi &Yanagimachi, 1976, Journal of Experimental Zoology 196; 189-196; Yamada et al.,

1992, Biology of Reproduction 46: 853-858; Farstad et al, 1993, Journal of Reproduction and Fertility (Suppl. 47): 219-226; Bolamba et al, 1998, Theriogenology 49: 933-942; Durrant et al, 1998, Theriogenology 49: 917-932; and Hewitt et al, 1998, Theriogenology 49: 1083-1101.

With regard to equids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Aim & Hinrichs, 1996, J. Reprod. Fert. 107: 215-220; Aim & Tomer, 1994, Theriogenology 42: 345-349; Hinrichs et al, 1993, Biol. Reprod. 48: 363-370; Hinrichs et al, 1995, J. Reprod. Fert. 104: 149-156; Hinrichs et al, 1995, Biology of Reproduction Monograph 1 : 319-324; and DellAquila et al,

1997, Theriogenology 47: 1139-1156.

With regard to ovids and caprids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Willadsen, 1986, Nature 320: 63-66; Ruffing et al, 1993, Biology of Reproduction 48: 889-904; Smith & Wilmut, 1989,

Biology of Reproduction 40: 1027-1035; McLaughlin et al, 1991, Theriogenology 35: 240; Campbell et al, 1995, Theriogenology 43: 181; Cambell et al, 1996, Theriogenology 45: 286; Campbell et al, 1996, Nature 380: 64-66; Wilmut et al, 1991, Nature 385: 810-813; Ledda et al, 1997, Journal of Reproduction and Fertility 109:73-78; Byrd et al, 1997, Theriogenology 47: 857-864; Wilmut et al, 1997, Nature 385: 810-813; LeGal, 1996, Theriogenology 45: 1177-1; Pawshe et al, 1996,

Theriogenology 46: 971-982; Gall et al, 1993, Molecular Reproduction and Development 36: 500-506; Walker et al, 1996, Biology of Reproduction 55: 703- 708; and Gardner et al, 1994, Biology of Reproduction 50: 390-400.

With regard to murids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. . See, e.g., Downs & Masfropolo, 1997, Mol. Reprod. Dev. 46: 551-566; Kim & Schuetz, 1991, Cell Tissue Res. 265: 105-112; Downs, 1995, Dev. Biol. 167: 502-512; Kite & Bavister; 1997, J. Reprod. Fert. 110: 35-46; Zhang & Rutledge, 1991, Mol. Reprod. Dev. 28: 292-296; Bos-Mickich & Whitingham, 1995, Mol. Reprod. Devel. 42: 254-260; Cufhbertson, 1983, J. Exp. Zool. 226: 311-314;

Shaw & Trounson, 1989, Gamete Res. 24: 269-279; Sakkas & Trounson, 1991, Reprod. Fert. Dev. 3: 99-108; Kito & Bavister, 1997, J. Reprod. Fert. 110: 35-46; Bavister, 1995, Human Reprod. Update 1: 91-148; Erbach et al, 1994, Biol. Reprod. 50: 1027-1033; and Ho et al, 1995, Mol. Reprod. Dev. 41: 232-238.

With regard to leporids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Kanka et al, 199, Molecular Reproduction and Development 43: 135-144; Lui et al, 1996, Molecular Reproduction and Development 45: 157-162; Du et al, 1995, Journal of Reproduction and Fertility 104: 219-223; Farrell & Foote, 1995, Journal of Reproduction and Fertility 103:

127-130; Sofikitis et al, 1996, Fertility and Sterility 65: 176-185; Adenot et al, 1997, Molecular Reproduction and Development 46: 325-336; Lorenzo et al, 1996, Journal of Reproduction and Fertility 107:109-117; and Jelinkova et al, 1994, Molecular Reproduction and Development 37:210-215.

With regard to mustelids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Johnston et al, 1994, Journal of Experimental Zoology 269: 53-61; Polejaeva et al, 1997, Journal of Reproduction and Fertility 109: 229-236; and Moreau et al, 1995, Biology of Reproduction 53: 511-518.

With regard to cervids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Berg et al, 1995, Theriogenology 44: 247-254; Berg et al, 1994, Theriogenology 41: 160; Fukui et al, 1991, Theriogenology 35: 499-512; and Pollard et al, 1995, Theriogenology 43: 301.

With regard to camelids, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Del Campo et al, 1995, Theriogenology 43: 21-30; Del Campo et al, 1994, Theriogenology 41: 187; McKinnon et al, 1994, Theriogenology 41: 145-150; Wiepz & Chapman, 1985, Theriogenology 24: 251-257; and Del Campo et al, 1994, Theriogenology 41: 1219-1229.

With regard to non-human primates, researchers have reported materials and methods for oocyte maturation, oocyte enucleation, cell activation, in vitro embryo development, and other processes. See, e.g., Edward, 1965, Nature (Lond) 208: 349- 351; Morgan et al, 1991, Biol. Reprod. 45: 89-93; Meng et al, 1997, Biol. Reprod. 57: 454-459; We et al, 1996, Biol. Reprod. 55: 260-270; Bavister et al, 1983, Biol. Reprod. 28: 983-999; Weston et al, 1996, Mol. Reprod. Dev. 44: 88-92; Enders et al,

1989, Biol. Reprod. 41: 715-727; Wolf et al, 1990, Molec. Reprod. Dev. 27: 261- 280; and Zhang et al, 1994, Biol. Reprod. 51: 433-440.

Each reference set forth in this section is incoφorated herein by reference in its entirety, including all figures, tables, and drawings.

IV. Cloned Animals

As described previously herein, the invention provides advantages of assessing the genotype and phenotype of an animal before cloning that animal. In preferred embodiments, an animal to be cloned is a mammal. Particularly preferred mammals are canid, felid, murid, leporid, mustelid, ursid, primate, ungulate, ovid, suid, equid, bovid, caprid, and cervid animals. Preferably, a cloned animal has a genome that is substantially similar to that of a nuclear donor cell. More preferably, a cloned animal has a genome that is identical to that of a nuclear donor cell. Differences between a genotype and/or phenotype ofthe nuclear donor cell and that ofthe cloned animal can result from natural processes, such as differences in DNA methylation or differences in telomere length for example, and can also result from differences in the intrauterine environment during development. Differences between nuclear donor DNA and that of a cloned animal may also result from the addition of one or more fransgenes.

A cloned animal can also be a member of a plurality of animals which share substantially similar, and preferably identical, genomes with a nuclear donor.

Differences between a genotype and/or phenotype of each cloned animal and that of other cloned animals descended from a common nuclear donor can result from natural processes, such as differences in DNA methylation or differences in telomere length for example, and can also result from differences in intrauterine environment during development, as described above.

Multiple products can be isolated from a cloned animal. The following discussion of such products is not meant to be limiting and the invention relates to any products which may be isolated or collected from a cloned animal using techniques known to a person of ordinary skill in the art. Products can be any body fluids or organs isolated from the animal, or any products isolated from fluids or organs. In preferred embodiments, products such as meat may be collected from cloned animals. In preferred embodiments, products may be present in mammary tissue of a female transgenic animal , or present in products of mammary tissue such as breast milk (containing one or more recombinant proteins), which may then be collected and subjected to purification techniques. In another example, semen can be collected from a cloned animal and cryopreserved. Semen can also be separated into sex-specific fractions of sperm. See, U.S. Patent Nos. 5,439,362, 5,346,990, and 5,021,244, entitled "Sex-associated Membrane Proteins and Methods for Increasing the Probability that Offspring Will be of a Desired Sex," Spaulding, and issued on August 8, 1995, September 13, 1994, and June 4, 1991, respectively, each of which is incoφorated herein by reference in its entirety including all figures, drawings, and tables. Methods of collecting semen are well known to a person of ordinary skill in the art, as discussed previously, hi another embodiment, the invention relates to determining a phenotype of an animal, which is a neutered animal, and then cloning this animal such that resulting cloned animals are reproductively functional and can be used to produce semen. Other preferred embodiments ofthe invention relate to such products as xenograft materials, sperm, embryos, oocytes, any type of cells, and offspring harvested from cloned animals ofthe invention.

Xenograft materials can relate to any cellular material extracted from one organism and placed into another organism. Medical procedures for extracting the cellular material from one organism and grafting it into another organism are well known to a person of ordinary skill in the art. Examples of preferable xenograft cellular materials can be selected from the group consisting of liver, lung, heart, nerve, brain, gallbladder, kidney, skin, bone, small intestine, large intestine, and pancreas cellular material.

As discussed in a previous section, transgenic animals can be generated from methods ofthe invention by using transgenic techniques well known to those of ordinary skill in the art. Preferably, cloned transgenic animals are produced from such methods. Cloned transgenic animals can be engineered such that they are resistant or partially resistant to diseases and parasites endemic to such animals. Examples of such diseases and parasites are outlined in a preceding section.

Moreover, cloned transgenic animals can be engineered such that they produce a recombinant product. Examples of recombinant products are outlined in a preceding section. Expression of such products can be directed to particular cells or regions within cloned transgenic animals by selectively engineering a suitable promoter element and other regulatory elements to achieve this end.

For example, human recombinant products can be expressed in urine of cattle by operably linking a uroplakin promoter to the DNA sequence encoding a recombinant product. Altematively, examples are well known to a person of ordinary skill in the art for selectively expressing human recombinant products in milk of an ungulate animal. Once a recombinant product or recombinant products have been expressed in a particular tissue or fluid of a cloned transgenic animal, suitable tissue or fluid can be collected using methods well known in the art. Recombinant products can be purified from such fluid or tissue by using standard purification techniques well known to a person of ordinary skill in the art.

V. Method for Treating a Disease or Disorder

The present invention also relates to a method for treating a disease or disorder comprising the step of administering to a patient in need of such a treatment one or more molecules identified as inducing or inhibiting developmental competence or as inducing lineage specific development in a cell line.

Toxicity and therapeutic efficacy of substances, or compounds, can be determined by standard pharmaceutical procedures in cell cultures or experimental animals. The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Compounds which exhibit large therapeutic indices are preferred. The data obtained from these cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized.

For any compound used in the methods ofthe invention, the therapeutically effective dose can be estimated initially from cell culture assays. For example, a dose can be formulated in animal models to achieve a circulating plasma concenfration range that includes the IC50 as determined in cell culture ( e.g., the concentration ofthe test compound which achieves a half-maximal disruption ofthe protein complex, or a half-maximal inhibition ofthe cellular level and/or activity of a complex component). Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by HPLC. The exact formulation, route of administration and dosage can be chosen by the individual physician in view ofthe patient's condition. (See e.g. Fingl et al, 1975, in "The Pharmacological Basis of Therapeutics", Ch. 1 pi).

It should be noted that the attending physician would know how to and when to terminate, interrupt, or adjust administration due to toxicity, or to organ dysfunctions. Conversely, the attending physician would also know to adjust treatment to higher levels if the clinical response were not adequate (precluding toxicity). The magnitude of an administrated dose in the management ofthe oncogenic disorder of interest will vary with the severity ofthe condition to be treated and with the route of administration. The severity ofthe condition may, for example, be evaluated, in part, by standard prognostic evaluation methods. Further, the dose and perhaps dose frequency, will also vary according to the age, body weight, and response ofthe individual patient. A program comparable to that discussed above may be used in veterinary medicine.

Depending on the specific conditions being freated, such agents may be formulated and administered systemically or locally. Techniques for formulation and administration may be found in "Remington's Pharmaceutical Sciences," 1990, 18th ed., Mack Publishing Co., Easton, PA. Suitable routes may include oral, rectal, transdermal, vaginal, transmucosal, or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as infrathecal, direct intraventricular, intravenous, intraperitoneal, intranasal, or intraocular injections, just to name a few.

For injection, the agents ofthe invention may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks's solution, Ringer's solution, or physiological saline buffer. For such transmucosal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art.

Use of pharmaceutically acceptable carriers to formulate the compounds herein disclosed for the practice ofthe invention into dosages suitable for systemic administration is within the scope ofthe invention. With proper choice of carrier and suitable manufacturing practice, the compositions ofthe present invention, in particular, those formulated as solutions, may be administered parenterally, such as by intravenous injection. The compounds can be formulated readily using pharmaceutically acceptable carriers well known in the art into dosages suitable for oral administration. Such carriers enable the compounds ofthe invention to be formulated as tablets, pills, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a patient to be treated.

Agents intended to be administered intracellularly may be administered using techniques well known to those of ordinary skill in the art. For example, such agents may be encapsulated into liposomes, then administered as described above. Liposomes are spherical lipid bilayers with aqueous interiors. All molecules present in an aqueous solution at the time of liposome formation are incoφorated into the aqueous interior. The liposomal contents are both protected from the external microenvironment and, because liposomes fuse with cell membranes, are efficiently delivered into the cell cytoplasm. Additionally, due to their hydrophobicity, small organic molecules may be directly administered intracellularly.

Pharmaceutical compositions suitable for use in the present invention include compositions wherein the active ingredients are contained in an effective amount to achieve its intended puφose. Determination ofthe effective amounts is well within the capability of those skilled in the art, especially in light ofthe detailed disclosure provided herein.

In addition to the active ingredients, these pharmaceutical compositions may contain suitable pharmaceutically acceptable carriers comprising excipients and auxiliaries which facilitate processing ofthe active compounds into preparations which can be used pharmaceutically. The preparations formulated for oral administration may be in the form of, for example, tablets, dragees, capsules, or solutions.

The pharmaceutical compositions ofthe present invention may be manufactured in a manner that is itself known, e.g., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes. Pharmaceutical formulations for parenteral administration include aqueous solutions ofthe active compounds in water-soluble form. Additionally, suspensions ofthe active compounds may be prepared as appropriate oily injection suspensions. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes.

Aqueous injection suspensions may contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents which increase the solubility ofthe compounds to allow for the preparation of highly concentrated solutions.

Pharmaceutical preparations for oral use can be obtained by combining the active compounds with solid excipients, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose,sodium carboxymethylcellulose, and/or polyvinylpynolidone (PVP). If desired, disintegrating agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate.

Dragee cores are provided with suitable coatings. For this puφose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses.

Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers may be added.

The proper dosage of a compound depends on various factors such as the type of disease being freated, the particular composition being used and the size and physiological condition ofthe patient. Therapeutically effective doses for the compounds described herein can be estimated initially from cell culture and animal models. For example, a dose can be formulated in animal models to achieve a circulating concenfration range that initially takes into account the IC50 as determined in cell culture assays. The animal model data can be used to more accurately

-determine useful doses in humans.

Plasma half-life and biodistribution ofthe drug and metabolites in the plasma, tumors and major organs can also be determined to facilitate the selection of drugs most appropriate to inhibit a disorder. Such measurements can be carried out. For example, HPLC analysis can be performed on the plasma of animals freated with the drug and the location of radiolabeled compounds can be determined using detection methods such as X-ray, CAT scan and MRI. Compounds that show potent inhibitory activity in the screening assays, but have poor pharmacokinetic characteristics, can be optimized by altering the chemical structure and retesting. In this regard, compounds displaying good pharmacokinetic characteristics can be used as a model.

Toxicity studies can also be carried out by measuring the blood cell composition. For example, toxicity studies can be carried out in a suitable animal model as follows: 1) the compound is administered to mice (an untreated control mouse should also be used); 2) blood samples are periodically obtained via the tail vein from one mouse in each freatment group; and 3) the samples are analyzed for red and white blood cell counts, blood cell composition and the percent of lymphocytes versus polymoφhonuclear cells. A comparison of results for each dosing regime with the controls indicates if toxicity is present.

At the termination of each toxicity study, further studies can be carried out by sacrificing the animals (preferably, in accordance with the American Veterinary

Medical Association guidelines Report ofthe American Veterinary Medical Assoc. Panel on Euthanasia, Journal of American Veterinary Medical Assoα, 202:229-249, 1993). Representative animals from each treatment group can then be examined by gross necropsy for immediate evidence of metastasis, unusual illness or toxicity. Gross abnormalities in tissue are noted and tissues are examined histologically. Compounds causing a reduction in body weight or blood components are less preferred, as are compounds having an adverse effect on major organs. In general, the greater the adverse effect the less preferred the compound.

For the freatment of cancers the expected daily dose of a hydrophobic pharmaceutical agent is between 1 to 500 mg/day, preferably 1 to 250 mg/day, and most preferably 1 to 50 mg/day. Drugs can be delivered less frequently provided plasma levels ofthe active moiety are sufficient to maintain therapeutic effectiveness.

Plasma levels should reflect the potency ofthe drug. Generally, the more potent the compound the lower the plasma levels necessary to achieve efficacy.

VI. Cell-Based Therapeutics

Cell-based therapeutics rely on the ability of a cell, and in particular a stem cell, to differentiate along a specific cell lineage. The ability to direct lineage-specific differentiation can provide a virtually unlimited suply of source material for the treatment of diseases by tissue repair and regeneration. For example, hematopoetic stem cells have been used for many years to repopulate the bone marrow of animals, including humans, which have lost the ability to produce one or,more blood cells.

Methods for administering cell-based therapeutics are known to those of ordinary skill in the art. See, e.g., Stein, et al, International Publication No. WO 98/39427, published on March 6, 1997, entitled "Gene Therapy Using Bone Marrow Transplants Transfected With Therapeutic Genes Under the Control of Tissue-Specific Promotors," which is hereby incoφorated by reference in its entirety, including all tables, figures, and claims. EXAMPLES

MATERIALS AND METHODS

Example 1. In vivo, In vitro, and Nuclear Transfer Embryos

Cryopreserved bovine in vivo embryos were purchased commercially. Bovine cumulus oocyte complexes were recovered from slaughterhouse ovaries by aspiration and in vitro matured in maturation medium at 39°C in a 5% CO2 in air atmosphere as described in U.S. Patent No. 5,453,366, issued to Sims et al. on September 26, 1995, and/or U.S. Patent No. 5,096,822, issued to Rosenkrans et al. on March 17, 1992, each of which is hereby incoφorated by reference in its entirety, including all tables, figures, and claims. A preferred maturation medium was prepared by combining 4.4 mL Medium 199 (Gibco-BRL 11150-042), 500 μL fetal calf serum (Hyclone), 50 μL Pen-Strep (Gibco-BRL 15140-122), 50 μL pyruvate (2 mg/mL in medium 199), 25 μL LH (Sioux Biochemical), and 5 μL estradiol (Sigma Chemical E-8875). Matured oocytes were inseminated by combining sperm and matured oocytes in a fertilization drop as described in U.S. Patent Nos. 5,453,366 and/or 5,096,822. CR2 medium (CRl medium supplemented with amino acids as described in U.S. Patent No. 5,096,822) + 6 mg/mL was preferred as a fertilization medium. Fertilized oocytes were matured in CR2 medium supplemented with 10% FCS and collected on five day post insemination.

Example 2. Cell Culture Conditions of Donor Cells, Embryonic Germ Cells and

Embryonic Stem Cells

Bovine embryonic germ cells were derived from the genital ridge of 55 day old bovine fetuses and cultured in alpha-MEM (Gibco-BRL) supplemented with 10% fetal bovine serum (Hyclone) and 0.1 mM 2-mercaptoethanol (Gibco-BRL). Confluent culture dishes were passaged in IX Trypsin-EDTA (Gibco-BRL) at least once before use in nuclear transfer. Bovine embryonic stem cells were derived from bovine nuclear transfer blastocyst that were on mitotically inactivated mouse fibroblast feeder cells in alpha-MEM (Gibco-BRL). Some ES cell cultures were supplemented with 50 ng/ml recombinant human leukemia inhibitory factor (rhLLF) (R & D Systems), 50 ng/ml fibroblast growth factor basic (bFGF) (R & D systems), and IX Antibiotic- Antimycotic (Gibco-BRL).

Example 3. Nuclear Transfer Embryos

Matured oocyte complexes were pooled in HECM/HEPES and vortexed for three minutes to strip cumulus and placed in Hoescht medium 30 minutes prior to enucleation. Enucleation (removal of polar body and metaphase plate) was performed and oocytes were flashed with UV light (less than 10 seconds) to confirm enucleation. Enucleated oocytes were washed with HECM/HEPES and put back into a drop of CR2 medium prior to transfer of donor cells within the oocyte cytoplasma. Fusion of the enucleated oocyte and the donor cell was performed on a BTX 200 Electrocell fusion machine in a 500 μM fusion chamber by an electrical pulse of 90 V for about 15 μsec. After fusion the resultant NTs were placed into CR2 medium plus fetal calf serum (Gibco-BRL) until activation. Fused NTs were activated between 4-9 hours later by exposing them to 5 μM ionomycin in HECM/HEPES supplemented with 1 mg/ml BSA for four minutes.

Example 4. RNA Isolation

Total RNA was isolated from single embryos (in vivo, in vitro, and nuclear transfer) using the RNeasy kit according to manufacturer's protocols (Qiagen). All buffers and reagents were supplied by the manufacturer with the exception of β- mercaptoethanol (Fisher Scientific). Briefly, in vitro and nuclear transfer embryos were collected (Day 5) and transfererd into 1.5 ml microcentrifuge tubes containing 350 μL RLT buffer and frozen at -80°C prior to RNA isolation. In vivo bovine embryos were cryopreserved prior to RNA isolation and transferred into a 1.5 ml microcentrifuge containing 350 μL RLT buffer prior to RNA isolation, β- mercaptoethanol (0.145M) was added to the RLT buffer and embryos after incubation on ice. The embryos were homogenized by vortexing for 30 seconds. After addition of 70% ethanol (350 μl) the homogenized lysates were applied to the RNeasy mini spin column and centrifuged for 15 seconds at 10,000 φm (discarded flow-through). The wash buffer RW1 (700μl) was applied to the RNeasy column and centrifuge for 15 seconds at 10,000 φm (discarded flow-through). The RNA was precipitated by addition of 500 μl of RPE buffer onto the RNeasy column and centrifuged for 15 seconds at 10,000 φm (discarded flow-through). An additional 500 μl of RPE buffer was applied onto the RNeasy column and centrifuged for two minutes at maximum speed to dry the RNeasy membrane. The RNeasy column was transfened into a new 1.5ml collection tube (supplied by manufacturer) and 30 μl of Rnase-free water was applied directly onto the RNeasy membrane. The RNeasy membrane was centrifuge for one minute at 10,000 φm to elute the RNA.

Alternatively, RNA is isolated from single embryos using the Micro RNA Isolation Kit (Stratagene) according to the manufacturer's protocols. Briefly, individual embryos were incubated in 200 μL of denaturing buffer and 1.6 μL of β- mercaptoethanol at room temperature for 5 minutes. Extraction was performed in 20 μL of 2M sodium acetate, 200 μL phenol, and 60 μL chloroform:isoamyl alcohol. The aqueous layer was collected and mixed with 1 μL glycogen (10 mg/mL), and precipitated with 200 μL isopropanol. The sample was washed with 70% ethanol, air dried, and resuspended in 16 μL RNase-free water, 2 μL DNase I reaction buffer, 1 μL RNasin, and 1 μL DNase I. The resulting solution was incubated at 37°C for 30 minutes, the nucleic acid was precipitated, and the resulting pellet resuspended in 10 μL DEPC-freated water.

Example 5. First-Strand Synthesis of cDNA and Amplication of cDNA

Total RNA isolated from single in vivo, in vitro, and nuclear transfer embryos was used to produce cDNA with the SMART PCR cDNA synthesis kit following manufacturer's protocol (Clontech). Briefly, 3 μl of RNA sample was combined with lμl of cDNA synthesis (CDS) primer (10 μM) (5'- AAGCAGTGGTAACAACGCAGAGTACTpo) N.i N-3'; N=A, C, G, OR T; N1=A, G, or C) and 1 μl of SMART II Oligonucleotide (lOμM) (5'-

AAGCAGTGGTAACAACGCAGAGTACGCGGG-3 ') into a 0.5 ml microcentrifuge tube. Contents were mixed and briefly centrifuged prior to incubation at 70°C in a therma cycler for 2 minutes. After incubation, the tubes were spun briefly in a microcentrifuge to collect contents at the bottom. The tubes were kept at room temperature. The following was added to each reaction tube: 2μl of 5X First-Strand Buffer (250mM Tris-HCl (pH8.3), 375 mM KC1, 30 mM MgC12), 1 μl of DTT (20mM), 1 μl of 50X dNTP (lOmM each dNTP), and 1 μl of.MMLV reverse transcriptase (Superscript II, 200 units/μl; Gibco-BRL). Microcentrifuge tubes were gently mixed and then spun in a microcentrifuge. The reaction mixtures were overlayed with one drop of mineral oil (to prevent evaporation) and incubated at 42°C for 1 hour in a therma cycler. The first-strand reaction product was diluted by adding 40 μl of TE buffer (10 mM Tris (pH 7.6), 1 mM EDTA). Microcentrifuge tubes were heated at 72°C for 7 minutes to inactivate the reverse transcriptase. For amphcation of cDNA, the PCR thermal cycler was preheated to 95°C. For each embryo cDNA sample, 10 μl of single-stranded cDNA was transferred into a 0.5 ml microcentrifuge tube. The following was added to each reaction tube (supplied by manufacturer; Clontech): 74 μl of sterile deionized H₂0, 10 μl of 10X Advantage 2 PCR Buffer, 2 μl of 50X dNTP (lOmM each dNTP), 2 μl of PCR primer (10 μM) (6FAM-5'- AAGCAGTGGTAACAACGCAGAGT-3'; modified at the 5' end with 6FAM), and 2 μl of 50X Advantage 2 Polymerase Mix. Contents in microcentrifuge tubes were mixed well and spun briefly in microcentrifuge. The reaction mixtures were overlayed with two drops of mineral oil (to prevent evaporation). Thermal cycling paramaters were as follows: one cycle at 95 °C for 1 min, followed by 25 cycles at 95°C for 15 sec, 65°C for 30 sec, and 68°C for 6 min. To confirm amplification of cDNA was successful, a 5 μl aliquot of each sample was electrophoresed on a 1.0% agarose/ethidium bromide gel in IX TBE buffer. Typical results, indicative of a successful PCR according to the manufacturer (Clontech) had a moderately strong smear of cDNA from 0.5 to 6 kb and several bright bands conesponding to abundant transcripts.

Example 6. Linear Amplification of RNA using T7 polymerase by Reverse

Transcription (RT)

10 μL of purified RNA was mixed with 1 μL T7-oligo(dT) primer (5'- TCTAGTCGACGGCCAGTGAATTGTAATAGCACTCACTATAGGGCGT₂₁-3') (0.5 mg/mL) to initiate first strand synthesis. The primer and RNA were incubated at 70°C for 10 minutes, followed by incubation at 42°C for 5 minutes. Next, 4 μL of first strand reaction buffer (2 μL 0.1M DTT, 1 μL 10 mM dNTPs, 1 μL RNasin (Promega), and 1 μL Superscript II (Life Technologies) were added, and the resulting mixture incubated at 42°C for 1 hour. Subsequently, 30 μL of second strand buffer (3 μL 10 mM dNTPs, 4 μL DNA polymerase I, 1 μL E. coli RNase H, 1 μL E. coli DNA ligase, and 92 μL RNase-free water) was added, and the mixture incubated at 16°C for 2 hours, followed by addition of 2 μL T4 DNA polymerase and incubation at 16°C for 10 minutes. cDNA was extracted with pehnol-chloroform, and washed 3 times with 500 μL on a Microcon-100 column (Millipore).

Amplification was accomplished using the Ampliscribe T7 Transcription Kit (Epicentre Technologies) according to manufacturer's instructions. Briefly, 8 μL of cDNA was added to 2 μL of 10X Ampliscribe T7 buffer, 1.5 μL each of 100 mM

ATP, CTP, GTP, and UTP, 2 μL 0.1 M DTT, and 2 μL T7 RNA polymerase, and incubated at 42°C for 3 hours. The resulting RNA was washed 3 times using a Microcon-100 column, collected, and dried to 10 μL.

RNA from the first amplification round was mixed with 1 μL random hexamers (Pharmacia) (1 mg/mL), incubated at 70°C for 10 minutes, chilled on ice, then brought to room temperature. To this sample, 4 μL of first strand buffer, 2 μL 0.1 M DTT, 1 μL 10 mM dNTPs, 1 μL RNasin, and 1 μL Superscript II were added, and the resulting mixture incubated at room temperature for 5 minutes, followed by 37°C for 1 hour. Subsequently, 1 μL RNase H was added, followed by an incubation at 37°C for 20 minutes, 95°C for 2 minutes, then chilling on ice. For second strand cDNA synthesis, 1 μL T7-oligo(dT) primer (0.5 mg/mL) was added, and the mixture incubated at 70°C for 5 minutes and 42°C for 10 minutes. To this solution, 30 μL of second strand synthesis buffer, 3 μL 10 mM dNTPs, 4 μL polymerase 1, 1 μL E. coli RNase H, and 90 μL RNase-free water was added, followed by incubation at 16°C for 2 hours. 2 μL of T4 DNA polymerase was then added, followed by incubation for 10 minutes. Double stranded DNA was then extracted with 150 μL phenol-chloroform, and washed using a Microcon-100 column. The resulting cDNA could be used for a additional rounds of in vitro transcription and RNA amplification. Example 7. Differential Display

The identification of differentially expressed RNAs from in vivo, in vitro, and nuclear transfer derived embryos was performed using reagents supplies in the Delta Differential Display kit and following manufacturer's protocol (Clontech). Briefly, 2 μl of PCR amplified in vivo, in vitro, or nuclear fransfer single embryo cDNA were used as templates and amplified in the presence of [α-³³P]dATP (50nM) (Amersham), 1.OμM each of arbitrary "P" and oligo(dT) primers, 2X KlenTaq PCR reaction buffer, 50 μM each dNTP, and 2.5X Advantage KlenTaq Polymerase Mix. Thermal cycling conditions were as follows: One cycle at 94°C for 5 min, 40°C for 5 min, and 68°C for 5 min; two cycles at 94°C for 2 min, 40°C for 5 min, and 68°C for 5 min; followed by 25 cycles at 94°C 1 min, 60°C 1 min, and 68°C for 2 min; final extension was performed for an additional 7 min at 68°C. Differential display products were loaded onto 6% denaturing polyacrylamide gels and electrophoresed at 70W for a minimum of seven hours. Polyacrylamide gels were fransfened to Whatman paper and dried under vacuum at 75 °C for 60 min. X-ray film was exposed to the gels at room temperature overnight with intensifying screens. Differentially expressed bands were excised from dried gels and fransfened into 0.6-ml microcentrifuge tubes. The gel slices (along with the Whatman paper) were soaked in 100 μl H₂O for 10 minutes, followed by heating at 99.9°C in thermal cycler for 15 min. Microcentrifuge tubes were spun for 2 min to collect condensation and pellet the gel and paper debris. The supermatants were fransfened to new 0.6-ml microcentrifuge tubes and 10 μl of 3M NaOAC, 5 μl of glycogen (lOmg/ml) and 450 μl of 100% ethanol were added. Samples were placed at -80°C for 30 min and spun at maximum speed in microcentrifuge for 10 min to pellet DNA. Supematants were removed and the DNA pellets were washed with 200 μl of ice-cold 85% ethanol. Samples were spun briefly and residual ethanol was removed. DNA pellets were resuspended in 20 μl of sterile H O. Eluted bands were stored at -20°C. Differentially expressed bands were reamplified using primer(s) used in the original differential display PCR. Each 12 μl reaction contained 2 μl of eluted DD band, 0.5 μM each primer, 0.8 μM each dNTP, 1.5mM MgCl₂, IX PCR buffer (AmpliTaq) and 0.2 units AmpliTaq DNA Polymerase

(Perkin Elmer). Thermal cycling conditions were: 3 min at 94°C, followed by 20 cycles of 1 min at 94°C, 1 min at 60°C, 1 min at 72°C, and a final extension of 4 min at 72°C. Re-amplication products were cloned into pGEM-T vector (Promega) and sequenced using ABI Prism BigDye terminator cycle sequencing kit (PE Applied Biosystems) and automated nucleotide sequencer (GeneSys). The resulting sequencing data were aligned and analyzed using SeqMan (DNASTAR), and BLAST (Basic Local Alignment Search Tool).

Example 8. Embryonic Germ (EG) Cell cDNA Library

A bovine EG cell cDNA library was custom made by Sfratagene (La Jolla, CA). Briefly, bovine EG cells isolated from the genital ridges of a slaughterhouse bovine fetus were grown at Infigen, Inc., in α-MEM (Gibco BRL) supplemented with 10%) fetal bovine serum (Gibco- BRL) and 0.1 mM β-mercaptoethanol (Gibso BRL). cDNA was synthesized from RNA isolated from 80 x 10⁶ EG cells. For directional cloning an Xho I site was introducted at the 3' end ofthe cDNA, by using an oligo(dT) primer contiaing an Xho I site for priming first strand synthesis, and ligating an EcoRI adapter to the 5' end ofthe double-stranded cDNA. The directional cDNA was then ligated into lambda arms ofthe Uni-ZAP vector (Sfratagene) cut with

EcoRI and Xhol. The average insert size is 1.0 kb with a size range of 0.5-2.2 kb. The estimated amplified titer is 1.2 x 1010 pfy (plaque forming units)/ml, representing 10⁶ recombinants. In vivo mass excision ofthe pBluescript phagemid from the Uni- ZAP XR vector was performed to generate a subtraction library. Briefly, overnight cultures of XL-lBlue MRF' and SOLR cells grown in LB broth supplemented with

0.2% (w/v) maltose and lOmM MgSO₄ were spun down and resuspended in lOmM MgSO₄ to an OD₆₀₀ of 1.0 (8 x 10⁸ cells/ml). In a 50 ml centrifuge tube 10⁷ pfu ofthe amplified lambda bacteriophage library was combined with 10⁸ XL 1 -blue MRF' cells and 10⁹ pfu of ExAssist helper phage and incubated at 37°C for 15 minutes. LB broth was added to the mixture and incubated at 37°C for 3 hours with shaking. The centrifuge tube was heated at 65°C for 20 minutes, followed by spining at 1000 x g for 10 min. The supernatant was decanted into a new sterile centrifuge tube, diluted, and combined with 200 μl of SOLR cells (previously diluted to 8 x 10 cells/ml) in a 1.5 ml microcentrifuge tube and incubated at 37°C for 15 min. A portion ofthe cell mixture was plated onto LB-ampicillin agar plates (100 μg/ml) and incubated overnight at 37°C. Individual colonies were picked from the agar plates and fransfened in single wells of a 96 well block containing 1.3 ml LB broth supplemented with 100 μg/ml ampicillian and incubated for 24 hours in a shaking 37°C incubator. The bacterial cells were harvested by centrifugation for 5 min at 1500 x g. Medium was removed by inverting the block. Plasmid DNA was isolated using the R.E.A.L. Prep 96 Plasmid kit (Qiagen) following manufacturer's protocol and supplied reagents. Briefly, bacterial pellets were resuspended in Buffer R2 and lysed after the addition of Buffer R3. The 96 well blocks were placed in a boiling water bath for 5 min and cooled down to room temperature by incubating on ice for 10 min. The bacterial lysates were fransfened to the wells ofthe QIA filter 96 well plate and fransfened to another 96 well block by vacuum. The DNA was desalted and concentrated by adding 0.7 volumes of room temperature isopropanol to each well and inverted to mix. The plasmid DNA was pelleted by centrifugation at 2500 x g for 15 min. DNA pellets were washed with 0.5 ml cold 70% ethanol and centrifuged to reconcenfrate the pellets. Plasmid DNA pellets were air dried and redissolved in 50

Example 9. Sequencing of Bovine EG cDNA/EST Library-

Sequencing of cloned cDNA inserts from the EG cDNA library was performed using the ABI Prism Big Dye Terminator cycle Sequencing kit (PE- Biosystems) following manufacturer's protocol and supplied reagents. Sequencing reactions were electrophoresed and analyzed using an automated nucleotide sequencer

(Genesys9600 and/or Perkin Elmer ABI 377). The resulting sequencing data were aligned and analyzed using SeqMan (DNASTAR), and BLAST (Basic Local Alignment Search Tools).

Example 10. Macroarray Preparation and Use

Insert cDNA samples from the bovine EG cDNA library were amplified by

PCR using flanking vector specific primers T7 and T3. Each 50μl reaction contained 2 μl of DNA template, IX AmpliTaq Reacton buffer, 1.5 mM MgCl , .5 μM each primer, 0.8 μM each dNTP, and 0.2 units AmpliTaq DNA Polymerase (Perkin Elmer). Thermal cycling conditions were: 3 min at 94°C, followed by 30 cycles of 1 min at 94°C, 1 min at 60°C, 1 min at 72°C, and a final extension of 4 min at 72°C. Following PCR amplification ofthe clone inserts, the PCR products were spotted onto neutral nylon membranes soaked in 0.5 M NaOH/1.5 M NaCl using the HDR tool and Biomek 2000 (Beckman). After spotting onto nylon membranes, the DNA was neufraliszed in 1.0 M Tris-Cl pH 7.4/1.5 M NaCl. DNA was cross-linked by UV inadiation. Nylon membranes were pre-hybridized at 65 °C for four hours in modified

Church buffer containing 0.25 M Na₂HPO₄ (pH 7.2), 7% SDS, lmM EDTA and 0.5 mg/ml denatured salmon sperm DNA. The membranes were hybridized in Church Buffer at 65°C for a minimum of 16 hours using ethanol precipitated amplified probe (previously described). Nylon membranes were washed twice in 2X SSC/0.1% SDS at room temperature with gentle agitation. To detect the hybridization of amplified probe to target, the ECF Signal Amplificaiton module (Amersham Pharmacia Biotech) was used. Briefly, after a blocking step, the membrane was incubated with an anti-fluorescein alkaline phosphatase (AP) conjugate (amplified probe contained 6FAM). After washing off the excess conjugate, detection reagent was added and probe-bound AP catalyzed the conversion ofthe detection reagent to a highly fluorescent product. The fluorescent product was visualized using a signal Fluorlmager (Molecular Dynamics).

Example 11 : Microanay Use

cDNA probes were labeled with Cye-3 and Cye-5 dyes using the Superscript Choice System for cDNA synthesis (Gibco-BRL) according to manufacturer's instructions. DNA affixed on a glass slide microanay was hybridized, and scanned using a Genepix 4000 Scanner and integrated software (Axon Instruments, Inc.). Formamide-based hybridization conditions at 42 °C were prefened over aqueous solutions containing either polyethylene glycol or dextran sulfate. Denhardt's Solution was prefened as a blocking reagent, although SDS, salmon sperm DNA, tRNA, or

Coti DNA may be used. Information related to intensity values, intensity ratios, normalization constants, and confidence intervals was assigned to each target. Data was typically viewed as a normalized ratio (Cye-3/Cye-5), in which significant deviations from 1 (no change) are indicative of increased (>1) or decreased (<1) levels of gene expression. Example 12: Developmentally Competent and Developmentally Incompetent Cell Lines

The competence of 59 bovine cell lines previously used in nuclear fransfer procedures were compared for the ability to produce live-born animals. The donor cell lines exhibit a range of competencies for successful reprogramming. Critical variables conelated with these competency ranges include culture media, number of passages and days in culture. The minimum standard for competency was defined as producing pregnancy initiation rates of greater than 50%, 90 days gestation, and live birth. 90 days appears to be a key indicator of live birth for cattle, as over 50% of NT fetuses that reach this mark survive full term. In tables 1 A and B, embryos generated from a competent donor cell line will be identified by a '+' while - embryos generated from an incompetent donor cell line will be distinguished by a '-'. For example, BFEG⁺ refers to a competent EG cell line, while BFEG^" refers to an incompetent EG cell line.

Example 13: Assessing the Effect of Changes in a Nuclear Transfer Protocol on Developmental Competence

Two cell lines in particular illustrate the differences in range of competencies: BFES⁺ and BFES^". These are embryonic stem cell lines cultured under different conditions and used to produce nuclear transfer embryos. Line BFES^" represents a stem cell line cultured using conditions that produced donor ES cells used for greater than 50,000 nuclear transfers. From this pool of NT embryos, 2000 were fransfened into recipients over a two year period, and all failed to develop beyond 55 days in utero. By contrast, using novel culture procedures aimed at minimizing differentiation and maximizing embryonic stem (ES) cell growth, Infigen generated stem cell line BFES⁺ to use as nuclear donors. Briefly, bovine embryonic stem cells were derived from bovine nuclear fransfer blastocyst that were on mitotically inactivated mouse fibroblast feeder cells in alpha-MEM (Gibco-BRL). Some ES cell cultures were supplemented with 50 ng/ml recombinant human leukemia inhibitory factor (rhLLF) (R & D Systems), 50 ng/ml fibroblast growth factor basic (bFGF) (R & D systems), and IX Antibiotic-Antimycotic (Gibco-BRL).

These cells were used to construct embryos that have sustained pregnancies greater than 90 days in 10% ofthe fransfened embryos. This data suggests that developmentally competent reprogramming can be enhanced by culture conditions of donor cell lines.

Example 14: Identifying Molecular Events Related to Developmental Competence by Immunoblot Analysis Immunoblot analysis was performed using standard protocols and essentially as described in Harlow and Lane (Antibodies: A Laboratroy Manual, pgs 471-506). Briefly, cells were grown as described previously and resuspended in approxiamtely 10 volumes of sample buffer (2% SDS, 100 mM DTt, 60 mM Tris, pH 6.8, 0.1% bromophenol blue). Samples were boiled for 5 minutes and immedialtely loaded onto 10-20% Tris/gly cine SDS -polyacrylamide gradient gels. Proteins were separated by electrophoresis at 100-125 V until the dye front reached the bottom ofthe gel. Proteins were fransfened to nitrocellulose in transfer buffer (50 mM Tris, 380 mM glycine, 0.1% SDS, 20% methanol) at 100 volts for 1 hour. Mouse anti-histone deacetylase 2 primary antibody (Santa Cruz Biotechnology, Inc.) was used at a dilution of 1:100 in blocking solution (5% wt/vol nonfat dry milk, 0.2% Tween 20,

0.02% sodium azide in PBS). Goat anti- mouse secondary antibody conjugated to horse radish peroxidase (Santa Cruz Biotechnology, Inc.) was used at a dilution of 1:500, also in blocking solution. Detection was accomplished using ECL+Western hotting detection system (Amershampharmacia, cat. # RPN2132). Immunoblot analysis has identified a potentially novel, 55 kD isoform of bovine histone deacetylase 2 (HDAC2) present in bovine BFES^" donor cells, but absent in competent bovine BFEG⁺ donor cells. By contrast, an approximately 60 kD band is detected in bovine BFEG⁺ cells but not BFES^" cells. (Fig. 2).

In addition, we have determined that histone deacetylase 1 is present in bovine BFEG⁺ cell lines but absent in BFES^" cells (data not shown). It has been presumed that successful reprogramming requires extensive chromatin remodeling, a process highly dependent on histone acetylases and deacetylases. See, e.g., Liang and Pardee, 1992, Science 251: 967-971; Wilmut, 1998, Scientific American 279: 58-63. Taken together, these observations suggest that donor cells can impact reprogramming and developmental competence by activating or deactivating genes and/or biochemical pathways that in turn could enhance or disrupt the reprogramming process. For example, novel deacytalses may alter chromatin remodeling kinetics. Example 15: Identifying Molecular Events Related to Developmental Competence by Differential Display

Differential display (DD) was used to compare mRNA profiles of single embryos'generated by nuclear transfer to in vivo embryos. The nuclear transfer embryos were reconstructed from a competent cell line [BFES⁺] and an incompetent cell line [BFEG^"]. DD was used to calculate the percentage of bands conserved between single day 7 in vivo embryos, and single day 5 NT embryos generated from incompetent EG^", and competent ES⁺ donor cells. It is important to note that day 7 bovine in vivo embryos and day 5 bovine NT embryos have identical moφhology, the same number of cells, and are considered to be at the optimal stages for comparison.

This analysis revealed a 73% difference in banding patterns between day 7 in vivo embryos and day 5 BFES⁺ embryos, and a 74% difference between day 7 in vivo embryos and day 5 BFEG^" NT embryos (Fig 3 ). A band was considered different if present in the in vivo sample but absent in either ofthe NT samples.

These results suggest that for individual embryos, mRNA expression pattems of embryos reconstructed with donor nuclei may not be converted to blastocyst pattems that represent the best model of successful reprogramming (i.e., in vivo produced embryo). These data further suggest a potentially large number of genes may have altered expression levels in NT reconstructed embryos when compared to in vivo embryos. The observation that nuclear transfer embryos reconstructed from competent cell lines may also have distinct DD pattems from in vivo embryo pattems may partially account for the poor efficiencies ofthe nuclear transfer process.

By contrast, researchers using differential display protocols demonstrated that expression patterns are highly conserved (-95%) between in vivo, IVF, and NT embryos, suggesting that developmental programs very similar to those detected for in vivo embryos can be established after nuclear transfer. See DeSousa et al, 1999, Cloning 1: 63-69. However, this analysis was based on single embryo equivalent representations obtained from pools of embryos. This method can mask differences between individual embryos, which in turn may account for individual embryo differences during development and the low live birth rates observed by artisans. For example, if 20% of NT embryos were developmentally competent, pooling template from 5 embryos likely would produce results substantially similar to results from a competent in vivo embryo. The data provided herein suggest that the vast majority of individual, NT reconstructed embryos may not reproduce expression patterns similar to in vivo pattems. The ability to monitor single embryos is critical to minimize genetic noise that might obscure underlying reproducible expression pattems. Since differences appear to be readily detectable at a single embryo level, deficiencies and/or differences in the mRNA profiles of NT embryos when compared to in vivo embryos ultimately will help identify genes/mechanisms responsible for low (live birth) efficiencies and developmental problems.

Figure 4 describes comparing banding pattems generated by differential display (Figure 4A & B) between five individual day 7 in vivo embryos (lanes 1-5); six individual day 5 IVF embryos (lanes 6 and 11)]; five individual embryos reconstructed by NT [three day 5 embryos (lanes 12-14), one day 7 (lane 15) and one day 8 (Lane 16)] using a developmentally incompetent cell line, and the developmentally incompetent donor cell (DC) line . Day 7 bovine in vivo embryos and day 5 bovine NT embryos have identical moφhology, the same number of cells, and are considered to be at the proper stages for accurate comparison. Briefly, RNA from each embryo was isolated, reverse transcribed and amplified using the protocol described previously. Differential display reactions were performed using one of 15 primer pairs. Analysis of banding pattems (Fig. 4A) revealed 122 bands present in aU 5 individual day 7 in vivo embryo samples. Seventy three (60%) ofthe 122 bands were also identified in five day 5 individual IVF produced embryos. (Less than 10% ofthe bands were present in the sixth, day 6 JVF embryo, lanel 1.) In shaφ contrast only 9 (7%>) ofthe 122 bands were identified in all ofthe day 5 individual embryos reconstructed by NT (Fig. 4B). (The number of matching bands was less for day 7 and day 8. The bands that did match showed altered expression pattems.) Moreover, these were the only 9 bands (of over 700 identified bands observed cumulatively in the 5 NT samples) present in all day 3 NT reconstructed embryos. This indicates tremendous heterogeneity among individual NT produced embryos collected at precise times after activation and not observed in either in vivo or IVF embryos. These banding pattems further support the hypothesis that low NT efficiencies may be due partly to improper reprogramming, exemplified by the different banding pattems between individual embryos reconstructed by NT. Most importantly, these data indicate that genes expressed at high levels in developmentally competent embryos, but at low or undetectable levels in developmentally incompetent embryos can be identified and used to determine an idealized expression pattern. The consistent amplification of identical bands in all individual in vivo embryo samples and all individual IVF embryo samples further demonstrates that the embryo harvesting and amplification protocols described herein are reliable for detecting gene products whose expression levels are either relatively high or low.

These results also suggest that, for individual embryos, mRNA expression pattems of embryos reconstructed with donor nuclei may not be converted to blastocyst pattems that represent a best model of successful reprogramming (i.e., in vivo produced embryo). This is further supported in a report by Eckert and Niemann (Mol. Human Reprod. 4: 957-65, 1998) who identified perturbations in mRNA expression pattems specific to the LLF-LLF receptor system in embryos generated in vitro and possibly conelated with improper blastocyst development. By contrast, de Sousa et. al. used differential display protocols to demonstrate that expression pattems are highly conserved (~95%) between in vivo, IVF, and NT embryos, suggesting that developmental programs very similar to those detected for in vivo embryos can be established after nuclear transfer. However, their analysis was based on pools of embryos. This method can mask differences between individual embryos, which in turn may account for individual embryo differences during development and the low live birth rates observed . For example, if 20% of NT embryos were developmentally competent, pooling template from 5 embryos likely would produce results substantially similar to results from a competent in vivo embryo. The data provided herein suggests the vast majority of individual, NT reconstructed embryos may not reproduce expression pattems similar to in vivo patterns. The ability to monitor single embryos is critical to minimize genetic noise that might obscure underlying reproducible expression pattems. Since differences appear to be readily detectable at a single embryo level, deficiencies and/or differences in the mRNA profiles of NT embryos when compared to in vivo embryos may help identify genes/mechanisms responsible for low (live birth) efficiencies and developmental problems. Example 16: Identifying Molecular Events Related to Developmental Competence by Differential Display Using Microarcays

Though differential display can be used to identify reprogramming differences between embryos generated by NT and those produced in vivo, the method cannot be used in a high throughput format and cannot be performed on a sufficiently broad scale to characterize reprogramming at a molecular level. Limitations include very labor intensive procedures after identification of differentially expressed bands and confirmation of differential expression. Also, standard differential display does not allow genomic scale comparison and sophisticated statistical analysis of expression data, and thus prevents 'rapid' elucidation of comprehensive molecular pattems and relationships. To reconfirm our results and compensate for the limitations of differential display cDNA microarray technology was used to investigate and compare expression profiles of single in vivo and in vitro derived embryos (Fig. 5).

The microanay was comprised of cDNA clones representing numerous functional classes and gene families, including unknown ESTs, genes putatively associated with reprogramming (SNF2), cell cycle progression (quiescen, cyclins), cell adhesion-extracellular matrix (collagen, fϊbronectin), apoptosis (p53), imprinting (lg£2 and Igf2r), transcription (STAT), embryonic signaling (interferon tau), and signal transduction (JAK) (Fig. 6).

To amplify and detect hybridization signals, protocols for linear and exponential amplification of cDNA representing mRNA from a single embryo were employed. See, e.g., Van Gelder et al, U.S. Patent.No. 5,716,785, issued on February 10, 1998, which is hereby incoφorated by reference, including all tables, figures, and claims. After incoφorating appropriate controls 744 PCR amplified anayed cDNA clones obtained from an anayed EG cell cDNA library were spotted onto nylon membranes, which in turn were probed with cDNA representations of a single in vivo embryo and 4 single embryos generated by NT from 1 competent (+), 1 unknown, and 2 incompetent (-) cell lines. A similar comparison of conservation after hybridization has confirmed basic plus/minus differences in expression pattems between individual embryos. Embryos generated from the 2 incompetent and unknown cell lines ranged in similarity from 18-85%, while the embryo generated from the competent cell line had a similarity to the in vivo embryo of 88%. Even a 3% difference in similarity between NT embryos generated from competent and incompetent (+ and -) donor cell lines represents -22 ofthe 744 genes screened with detectable (on/off) plus/minus differences. Studies in Phase II propose measuring expression levels of 10,000 genes. These data suggest that, from this pool, as many as 300 genes may have detectable plus/minus expression levels, and many more will likely have less subtle, but measurable differences. These results are the first visualization of broad changes in mRNA expression pattems between individual nuclear fransfer and in vivo embryos.

Nucleotide sequences analyzed by the methods described herein are provided in Tables 2 and 3. Each sequence was determined to have a positive, negative, or neutral association with successful cellular reprogramming. The individual nucleotides in these sequences are provided as A=adenine; T=thymine; G=guanine; C=cytosine; N=nucleotide not determined. Individual sequences in Table 2 begin with a sequence identifier, and are separated by blank lines, while those in Table 3 are separated by two blank lines.

Example 17: Statistical Analysis of Molecular Events Related to Developmental

Competence

Clustering analysis was used to identify an idealized expression pattem for a developmentally competent embryo. 14 genes uniquely associated with reprogramming were identified (Fig. 7). The following EST sequences were identified as being associated with reprogramming: 990809a-88, 990726a-13,

990726a-14, 990726a-14, 990729a-l, 990729a-13, 990928a-9, 990928a-10, 990928a- 65, 991108a-13, 991108a-14, 991108a-87, 991115a2-13, 991115a2-24, and 991115a2-92. Thirteen genes were always expressed in both the in vivo and competent cell derived embryos, but not in any ofthe embryos generated from incompetent cell lines. One gene was not expressed in the 2 competent embryo samples, but was detected in all three incompetent samples. The embryo derived from the unknown cell line had an expression pattem that matched 100% the embryos generated from the 2 incompetent cell lines. Transfer of embryos generated from the unknown cell line into recipient heifers failed to meet the criteria of a developmentally competent cell line (no pregnancy initiation was detected for any of the recipients), suggesting that it may be feasible to 1) identify an 'idealized expression pattern' of genes representing developmentally competent reprogramming and 2) identify genes that can be used to predict developmental viability. Gene expression differences between in vivo and nuclear transfer embryos are likely to contribute to the high inefficiencies associated with nuclear transfer cloning and potentially represent reprogramming deficiencies.

Example 18: Identifying Developmentally Competent and Incompetent Nuclear

Donor Cell Lines, and Developmentally Competent and Incompetent Nuclear Transfer Embryos

In order to determine if a nuclear donor cell line is comprised of developmentally competent or incompetent cells, one or more cells are separated from the cell line and used as nuclear donors to provide one or more nuclear transfer embryos by the methods described herein. RNA or protein is isolated, and optionally amplified, for identification of molecular markers that indicate developmental competence or incompetence. If the embryos are cultured in vivo or in vitro to at least the two cell stage, the embryo can be divided into two or more portions, such that at least part ofthe embryo is retained for possible implantation into a maternal host.

The invention illustratively described herein may be practiced in the absence of any element or elements, limitation or limitations which is not specifically disclosed herein. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention that in the use of such terms and expressions of excluding any equivalents ofthe features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope ofthe invention claimed. Thus, it should be understood that although the present invention has been specifically disclosed by prefened embodiments and optional features, modification and variation ofthe concepts herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the appended claims.

The contents ofthe articles, patents, and patent applications, and all other documents and electronically available information mentioned or cited herein, are hereby incoφorated by reference in their entirety to the same extent as if each individual publication was specifically and individually indicated to be incoφorated by reference. Applicants reserve the right to physically incoφorate into this application any and all materials and information from any such articles, patents, patent applications, or other documents.

The inventions illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Thus, for example, the tenns "comprising", "including," containing", etc. shall be read expansively and without limitation. Additionally, the terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents ofthe features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope ofthe invention claimed. Thus, it should be understood that although the present invention has been specifically disclosed by prefened embodiments and optional features, modification and variation ofthe inventions embodied therein herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention.

The invention has been described broadly and generically herein. Each ofthe narrower species and subgeneric groupings falling within the generic disclosure also form part ofthe invention. This includes the generic description ofthe invention with a proviso or negative limitation removing any subject matter from the genus, regardless of whether or not the excised material is specifically recited herein.

Other embodiments are within the following claims. In addition, where features or aspects ofthe invention are described in terms of Markush groups, those skilled in the art will recognize that the invention is also thereby described in terms of any individual member or subgroup of members ofthe Markush group. Table 1 and B: illustrates data concerning the developmental competence of 59 different nuclear donor cell lines.

Table 1A: Incompetent cell lines.

Cell Line: Pregnancy Initiation (%) Full term calves Number of ongoing pregnancies

BF101/65-C238-15 0 0 0

BF104/15-16 0 0 0

BF108-17 10 0 1

BFl2n2-I8 15.79 0 0

BF13nl-19 10.00 0 0

BF15-20 13.64 0 0

BF15-21 18.75 0 0

BF 15-22 25.00 4 0

BF 15-23 4.55 0 0

BF15-24 19.77 0 0

BF15-25 20.25 0 0

BF15-26 40.00 0 0

BF15-27 20.00 1 0

BF 15-28 36.36 0 0

BF15-29 1.92 0 0

BF15-30 13.24 0 0

BF15-31 29.41 0 0

BF15n4-32 22.22 0 0

BF15n7-33 37.50 0 2

BF19-34 33.33 1 0

BF24/15-35 25.00 2 0

BF33/21-36 0.00 0 0

BF65-37 27.27 0 0

BF65-38 44.44 0 1

BF65-39 ' 28.13 - 0 0

BF65cl l9-40 15.79 0 0

BF65c238-4l 21.05 0 0

BF6Sc36-42 34.78 0 0

BFES--43 33.00 0 0

BF65c46-44 37.50 0 1

BF65c7-45 38.10 0 0

BF65c7-46 33.33 0 0

BF65c9-47 0.00 0 0

BF68-48 20.00 0 0

BF68n2-49 16.67 0 0

BF74c2-50 0.00 0 0

BF75-51 40.00 0 2

BF83/65c36-52 41.67 0 4

BF85c2-53 45.45 0 2

BF85c26-54 30.77 0 3

BF85c51-55 45.45 0 4

PGC-56 12.12 4 0

PGC-57 12.2 2 ^■ 0

PGC-58 8.33 I 0 Table IB: Competent Cell Lines:

Cell Line ID Pregnancy #Full term # Ongoing initiation (%) calves Ppregnancies (> 90 days)

BF12n7-l 50.00 11

BF15-2 54.55 4

BF15-3 58.8 4

BF15-4 61.54 5

BF21-5 62.5 1

BF22/15-6 64.29 3

BF25-7 68.75 5

BF83/65-8 50.00 - 2

BF84/65-9 68.42 - 7

BF85cl02-10 76.92 - 2

BF85cl9-l l 50.00 .- 2

BF90/68-12 60.00 - 5

BF91/65c42-l 58.33 - 1

Table 2.

>'000127a-001.scf came from CONTIG 1 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-001.scf'(43>314)

AATTTGGCACGAGACTCATTTACGAAACCGGGCTGGAACCGCAGCTGTCGCGGATCTGAA

CGCGAGCTGTTCCTGTGGGTGCGCAGCTACCTTGCTGCGGACAGCTGAGGGAAAAAGGAA

GATGGGGTCTTTTGTCTCATTTTTGAAACCTCGGAAAACTGTCACCATGCCCCACTCCTAC

CCCACCCTTTCTGTTGAGCAGAAAAAAGAGATGTTCGACATTGCCCTGCGGGTTGTGGGG

CCAAGCAAAAGCATTCTGGCCGCAATGAAAA

>'000127a-002.scf came from CONTIG 2 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-002.scf'(48>536)

CTCGAGGTGGACACCACCCTCAAGAGCCTGAGCCAGCAGATCGAGAACATCCGGAGCCCT GAAGGCAGCCGCAAGAACCCCGCCCGCACCTGCCGTGACCTCAAGATGTGCCACTCTGAC TGGAAGAGCGGAGAATACTGGATTGACCCCAACCAAGGCTGCAACCTGGATGCCATTAAG

GTCTTCTGCAACATGGAAACCGGTGAGACCTGTGTATACCCCACTCAGCCCAGCGTGGCC CAAAAGAAACTGTATATCAACAAGAACCCCAAGGAAAAGAGCACGTCTGGGACGGCGAG AGCATGACCGGCGGATTCCAAGTCGAGTATTGCGGCAGAGGTCCGATCCTGCCGATGTGG CCATCCAGCTGACTTTTCTGCGCCTGATGTGCACCGAGGCCTCTCAAATCATCACTTACAC TGCAGTACACGTGGCCTACATGACCACAGACTGGCACTCAAGAGGCCCTGCTCTCAGGCT

CACGAATNG

>'000127a-003.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-003.scf'(55>553) GCACGAGGCAACCTCACGCTGCGGGACTACAGCGGACAGGGAGTCGTGAAACTGGACGT

CCAGCCGAAGTGCTTGGCCGTCGGCCCCGGGGGCTACACCGTGGTCGTGTGCATTGGCCA GATCGTTCTGCTGAAGGACCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTATGAGCC CGAAGTAGTGGCCGTGCACCCGGGTGGTGAGACAGTGGCCGTCGGGGCGCGGATGGAAC GTCCGNCTCTACTCATCCTGGCACCACGCTGAAGACGAGGNCAGCTCTGGAGCCAAGGCC CCGGCCGACTGGCGTTTCCCACGACGCGCCTTCTGCTGGTGCGACCCACAAGTGTCACGTC

TCACGTTGCGACGCTATCGAGACACGTTTTATGACACACAAGATGTTGCTGCCGTCTCGAC ACACATTGCTGGTGCTGAATATGGATGGTGACCTGAGACTAACAGTANATCAATGCACGT CCATGACATGCTGTGAAAC >'000127a-004.scf came from CONTIG 4 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-004.scf'(48>649)

CCTCAGCTGCCCCCACCAGCTCCTGGGGTCCACCCACCAGCACCAGTGGTCCACCCACCA GCCTCGGGGTGCATCCCCCTGCTCCTGGGGTTCATCCCCCAGCTCCTGGGGTCCACCCCCC AGCACCAGTGGTTCACCCACCAGCATCTGGGGTCCACCCCCCAGCTCCAGGGGTCCACCC TCCAGCCCCAGGAGTCCACCCTCCTGCTCCGGGAGTCCACCCTCCAGCCCCAGGGGTCCAT

CCTCCCCCATCTGCTGGCGTTCACCCCCAGACACCAGTGGTGCACCCACCAGCTCCTGCAG TTCACCCCCNAGCTCGGGGGTGCACCCAACTCCTGCAGTTCACCCCCANGCTCCAGGGNTC CACCCACCAGCTCCGGNGTCCACCCACCAGCCCCTGGNATCCACCCCAGCCTCTGGNGTC ACCCNNCTCTCTGNNGTCATCTCCGCTCTGGGTCCATCCAGCACTGNGTGCACCCTCAATC TGGTGCATTCCCACACCTGCCCGTGCTGAGCCCCATACCTCGAGCCTGGACTTCTCCCTCC

CACACTGAACACCCTACTCGTTGTTTGTTTΓGGTΓGCCTAAAAATTTTGTGCTGGG

>'000127a-005.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-005.scf'(53>543) GCACGAGGGTCATCAAGGTGCAGTTGGCAGTCCAGGCCCTGCAGGCCCCAGAGGACCTGT

TGGACCTACGGGCCCCCTGGCAAGGACGGAGCAAGTGGACACCCTGGTCCCATTGGACCA CCGGGGCCCCGAGGTAACAGAGGTGAAAGAGGATCTGAGGGCTCCCCAGGCCACCCAGG ACAACCAGGCCCTCCTGGACCTCCTGGTGCCCCTGGTCCATGTTGTGGTGCTGGCGGNGTT GCTGCCATTGCTGGTGTTGGAGCCGAAAAAGCTGGTGGGTTTGCCCCATATTATGGAGAT GAACCGATAGATTTCAAATCACACCGATGAGATATGACCTCACTCAATCANGTCATGGAC

AAATAGAAGTCTCATTAGTCTGATGGTTTCCGTATAACCNTGCACGGACTGCAGGNACCT GAATCTGCCATCTGACTCAGATGGAGATATGNNGTGTATCTACCAAGNTGCAAATGATGC TTTTAGTCTAT >'000127a-006.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-006.scf'(47>578) fAAACCCAAGCCCTTGACCTCTTACAGGAGCTTTGTCTGCCCTCTTAATAACATCCGGCCT AACCATGTGATTTCACTTTAACTCAATGACCCTGCTAATAATTGGCCTAACAACAAATATA CTAACAATATACCAATGATGACGAGATGTTATCCGAGAAAGCACCTTCCAAGGGCACCAT

ACCCCAGCTGTCCAAAAAGGCCTCCGTTATGGAATAATTCTTTTTATTATCTCCGAAGTAC TATTCTTTA(^GNATTTTCTGAGCTTTCTACCACTCAAGCCTCGCCCCCACCCCTGAACTAN NGCGCTGCTGACCCCCACNAGCATTCACCCACTAAACCCCTANAAAGTCCACTGCTCACA CCTCTGTCCTATGGCTTTCGGAGTTCTATTTACTGAGCCATCATATTTATAGAAGGGACGA AGCTATATACAGCCTATTTTCACATACATAGATCTATCACACTATCANCTCAATATTGAGC

ACTTATTCTCGAGNGTTACGTCATTTTGTACCAGCTCCGCTCCTC

>'000127a-007.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-007.scf'(52>397) GCACGAGGAGATGGCGGGTGACGACAAGCACATGTTCAAGCAGTTCTGCCAGGAGGGCC

AGCCACATGTGCTGGAGCTCTGTCCACCCAACCTAGCCTACCCACAATGGTAAACCAGGG GGAGATGAAGCCCTACACAGGCACCGAGACCTTTACTATGCCCTATGATTTCGCGATCATT ACCACCGACCTATTACCGACCACCTATGGGGACCATCATGGCGTTACGCGGAGATAGCCG ACCCATGGAGGGAAGAATTGTGTGAGTATTAATCACAATGATAACTTGGAATGACTGTCT ATATTTTAAGGTAGTTGTTTTTGGTTTAGTCCTATCTGGAGAGTGA

>'000127a-008.scf came from CONTIG 8 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-008.scf'(46>662)

GGCCAGTCCTCTACCCTCACTTCAGGCTCTCAGATCCCAACTCTTGTCCCACTCGTCGAGC GTTAACTGATGTTATGGTTTAAGTAGTGCTGAAATTTTGGTGGCTAATCTGCCTCCACCCC

TAGCCACAGAGATCCCTTTTTTGGAGGAATGACTCGCGATGAAGACGAAGATGATGAGGA AGAGGAAGAAGAAGGAGTCACGTGGGGCCGTGGGAACTCGAGGTTTGAGGGTCCCCAGT CCCCCGAGGAATTTAGCTTTGGCTTCAGCTTCAGCCCAAGAGGAGGAATGCGTTTCCACG ATAACTTCGNCTTTGATGACCTAATACGGNATTTCAATAACATCTTCAGCGAGATGGNGGC CTGGACCTTGCCTTCCCGCCCCTCTGTACTTCCAGGTCCTGAGTCAGAGACACCTGGTGAG

AGACGGCAGTAGGACAGACGCTTCGGACTCATGCTTTATTATNCANATATCACAGCCCAG ACTTNGTGGGGCTGGNAAGGAGCANGACTGTATCTCCAACACACCGACGTGCCNCCAAAC TTTCTAGNTGTGAACTGNCTGACCCCCTCTAACAGAAAAATGATTTTTTCAGTTTCAGAGT TTGCCATTGGGCC

>'000127a-010.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-010.scf'(52>598)

GCACGAGGGTGAGCAAGCCCACTCTGCTGGCATCACCTCCTGCTCAGGTTTTCTCTGCCAG CACAGCCCGGCTTGGGTCAAGTGGTCAGAGTATGTGGCCATCTTGTCACCAGCGGAAGGA ACGTGCAGGGAACATCGCTGCTCTGGTTGACTGACAGGCTGGGCTGCAGAGCGGCTCCTG

GAGCAGCTCAAGGCCTGCGAGCTGCAGGATGAGGCTGACATGCAGCGGTAGTTCCCGCAT GGCCCAGGCCCTGGGCTGTGCAGGGGACTCNGATGAGGAGTTCACCAGCTGCTACCCAGA CCACCCCGAGACCTGCATCTTNGCACCATGACGATATCACAGGACAAGGCTGTCTTCATG GAGGGCCATGTTCTTGTGTCCACAGTGACCTGAGTCACTGAGGTTTATGCACAGACTNGTG GTCAATAACGGNTGTGTAGCCAGTCACTGGTGAGTANCCAACACGTGGTTTTTCGAACAG

GCAGCGTCAGGCTGAAGTGGAAGAATCAGATGTTACAGAACGATCACCCAACTCACGTGT TGTCT

>'000127a-011.scf came from CONTIG 10 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-01 l.scf ' (49>614)

GCACGAGGCTCCACAGTTCAAAAGACCCCTTTCATCACCAACCCTGGGTATGACACTGGA AACGGTATTCAGCTTCCCGGCACTTCTGGTCAGCAGCCCAGTCTTGGGCAACAAATGATCT TTGAGGAGCATGGTTTTAGGCGAACCACACCGCCCACCACGGCCACCCCCGTAAGGCATA GGCCAAGACCGTATCCGCCGAATGTAAATGAGGAGATCCAAATTGGTCATGTCCCCANGG GAGACGTAGACCATCATCTCTACCCTCACGTTGTGGGACTCAANTCCAATGCTTCTACNAG

CCAAGAAGCTCTCTCTCANACAACCATCTCATGGACCCCATTNCCAGAAAGCTCTGAGTAT ATCATTTCATGTCATTCAGTTGGCATTGATGAGAACCTTACAGTTCGAGTTCTGGATCTTG CTAGGCCACCTGACGGCCTCACAGAGGNCCACTACACATATATGAGGAGTAAAGACCACG AGCAGAAGTGCGGAGNTGGTACGTGGCATCTGTGACAGGCGATCACCCAAGATCTGTTCA CCTACGNTCCATTGCTGGAGAN

>'000127a-012.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-012.scf'(48>603)

TTGCAAAGACACTAGGAAAACGGTCTTCTTTGCTAGGCTCTCAAGATGAGGCTTGGCCGA ACAGGTTCTGTTACTATTTTTACCTTCACAGTTATCGTTAGTTCCATATGTTTGTCAAAACA CAGACCATTCTCGTTCCCCAGCTAGAAAGCAATAGGTTAAATTCTAAAAGCTGTTTGCTTT TTCGTCTTCGCCTTTAAATCCTTGGAAGTTATCTCTTCCTGCTCCCCTACAGTATATATGGT TGGGAAACTGTGAAAGGAAGAAGGNGTGGTCTGTNAGGGAACTCCATCCATGGGGCCTN

CTAGAGCGGGTGTNGTGTTCCTACACCACTCCCCTCTCAGCAGAAGGGCTGCACACACAT ACACCAGAGAACTTCGCCTTCCTTTTTCACTTNCCACTTCCCACCATGCTTCGTTTACTACT AGATGAGAGTTATGACCACAGCTCTANACGTTACGCTTTGTATTATTAATTTCATACATAN ACATCTTGTCTACACCANACTACATAGTCGTTGTCTATACTTTATATAGGNTAGNGGGATG TACTTATA

>'000127a-013.scf came from CONTIG 12 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-013.scf'(52>585)

GCACGAGGCATGACTGACAATGATCTTATCAATATTCTTGACCCTTTTTATCATCTTTCAAC TAAAAGTTTCAAAACACAACTTTTATCACAATCCAGAACTGACACCAACAAAAATATTAA

AACAAAACACCCCTTGAGAAACAAAATGAACGAAAATTTATTTACCTCTTTTATTACCCCT GTTATTTTAGGTCTCCCTCTTCGTACCCTTATCGTACTATTCCCAAGCCTACTATTCCCAAC ATCAAACCGACTAGTAAGCAATCGCTTTGNTACCCTCCACAATGAATACTTCAACTTGTAT CAAAACAAAAATGAGTATCCACAATTCTAAAGGACAACATGAACATTATATTATATTCTG ATNCTATTTTTTGATCATCAATCTACTAGCCTATACCCATTCTTTCCACCACACACACTATC

ATAACTAGCTACCCTCCCTGTGGCGNAGCGGATCAGATCGCATATATAGCTACTGCCTTTT TACCAGACACCCTCCTATCATCTNATTTGATTTACTTTTTTTCTN

>'000127a-015.scf came from CONTIG 13 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-015.scf'(48>658)

AATAAAAAATACTATGACTAAAATTACTGTGGTTGAGAAATTTGGGTAATTTATAGTACC AGTGTTCAGAAATCTTCCTAACTTGTATTTGGTAACCCAAGTAAACAATTTCAGCTAATCT CAGATGGATTATTTTACTTATGAAATTTCTCTGTTCACTTTCTCTTCTTTATCCTGCTTCACA GCTTTTGGGTGTTGCCACATGATAAAGTATCATATCAACTCTAGATGATTAGGCAGAANAT TTTTATCAAAGTCAAGNGTTACTTTTTAGCAACTGGGTAAAGGNAAGNNGACTAATAGCT

GCTTCATTANAAAGAAACTCAAAAATATACAGNTCTCTTTANTAGACATAGCATACAGCA TACAGTTCTTCACTAGATATTGCTTAGATGTTACCACTTCTTTGCACTATTCTAAAGATGAA ACAGAANATAAACTACTANAACACAGGCAGAATCTCTCTATGTTTATTCTTTGCTCAAACT GGGCTTGATNAGGTTCTACTGAACCACTACCTTTTNTGTAGACAGGCAATTACGGAGATTA TAAGTCTTTTAGCCTTCCCACCAAATTTTTAATGCTTTTTTCTACAGCATTAAAATTAATGT

>'000127a-016.scf came from CONTIG 14 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-016.scf'(52>645)

GCACGAGGGTACAGAGGCCGGCTCCCGGAGCCAGCTGAGTTGCGGCCTCTACGACATGTC GGCGCACCAGCAGGGCACGGAGCTCGACCTTAGCTGGATCTCCAAAATACAAGTGAATAA

ACCAGCAGTGCTAAGACGTGCAGAACAAATCCAGGCTCGTAGACCTGTGAAAAAGGAGT GGCAGGCTGCATGGCTCCTGAAGGCTGTTACCTGTATAGATCTTACTACACTNTCAGGTGA TGACACAGCTTCCAACATTCAAAGGCTGTGTTATAAAGCCAAGTATCCAATCCGGGAAGA CCTCTTAAAAGCTNTAAATATGCATGATAAAGGCATCACTACAGCTGCCGNTTGTGGTTAT CCTGCCCGCGNGNGNGATGCAGTGAGAGCTCTAAGGCTGCGGCTGTGACATCCCATGGCA

TCAGGGGCCCTGGCTTCCGCTGCACAGACTCATTGATACACGATTAGAGAATAGATGGNC GGGNAGAGGGCTACGGAATGAGGGNGGATAACAGACTGGGCTGCAGCCAGGAAGCCGNT GAGAGACGCAGTGCAGGCGGGGAGCATCCAACATCTACCAGAATGATCTCCAAN >'000127a-017.scf came from CONTIG 15 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-017.scf'(52>584)

GCACGAGGAAATTATTTACTAAACTAAACCTTAGGAAAAGATGTTTTGCATCAGTCTTAAT

AGGCAAAAAGTΓCATGCTTAGTGACTGGAGAGATTTTTGCTTATAGCTTTTCCCTCTATAA

ATACTATCTAGAATGAAAGCTAATTTAGGAACAAGACTAACATTCAAAAAACCCTTAGTG CATATATTTTTAATTATTATTAGCTCATTATTAGATCATTTATTNTCATCTGTATTTGCCA AAAATTTATTTGCCTTTATATCTTTAGAATATTGAGTTTGTGTCTTTCTGTTTATCAπ^ CAAGTTTTATAAAAAGAACCTTCACTAGTACATGCCAGAAGATCATATTTCTGCTAAGTAT TATTNTTTTTAAAATCAGATGTCGCTGTATTATTGGTCATGCAGCGAGTAGAGGAAATGTA CAGACAGAGTTTTCTTTAGCCATGACCTTTCTCTCTGNAGNTGNTGCTTTAAGCAGATTTCT

CTTATATATGNCTTCTTTCTCTACTCTTAGATACTTGCTGT

>'000127a-018.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-018.scf'(44>670) GAGCCCACCTGGAGCTGCGCGCAGGCTTGTAGCGCGGAGCCCAGCGCAGAACCTCGCCCG

CGCAGTCCCTCGCGCGCCCCGCGTCTCGGCGCTGATTTCCAGGCCCCGGAGCCGCGCCAA GCGCTGCGAGCGGACCCGGGAAGAGCTCCGGCCCCCGCCGCCACCGCTTCACCGGCTTGG CTCCCTCCGCCCCCGGGGGGTCGCGCACCCACGATGCTGCAGGGCCCCGGCTCCCTGCTGC TGATCGTCCTCGCCTCGCACTGCTGCTTGGGCTCGGCGCGCGGGCTCTTCTTCGCCAGTCC GACTTCCCCTACAAACGCAGCAACTGCAAGCCCATCCCGGCCAACCTGCAGCTGTGCCAC

GGCATANAATATCAAAACATGCGGCTGCCCNACCTGCTGGGNCACGAGTACATGAGGNA GGTGCTAGAGCAGGCGGCGCCTGGATCCGCTGGTCTGAAGCATGCCACCGGACACCAGAA GTTCTGTGCTGCTCTTCGGCCGTCTGGCTCGACGACTGGAGAAACATCAGCCGGCACTGCT CTGGTGCAGTGAGACCTGGCTCATCATGTCGCCTTGCTTCGTGGNCGATGCTGATGTACGC TCCCAGAACACACTTGCTCCCTCT

>'000127a-019.scf came from CONTIG 17 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-019.scf'(51>444)

GCACGAGGAAGATGGCCTCGGGCCCCACGAGCATCCGCGTGCACTTCCAAGCCGGCCGCT TCCACCTGGACGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACG

TGGCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCGGCCGCTGC AGGAGCTGTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCGAGAAACCTGCGCGCATCC CCCTCAACCCCGTCCTCCGCGACTACCTGAGCTCCTTCCCCTCCANATCTGACCAGCCGCA CACCGCAACATTACTGNAGCGCCCTCTACTATTTTCTATATTATTATTATTTTNNCTGACAT GTGGNTGCCTTCCCATCTGGTGTAGGTACGG

>'000127a-020.scf came from CONTIG 18 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-020.scf'(41>577)

CTCGTATTTGATGGACTCTAACTACATCGATCCGAAATTTCCTCCATGCGAAGAATATTCG CAAAATAGCTACATCCCTGAACACAGTCCGGAATATTACGGCCGGACCAGGGAATCGGGA

TTCCAGCATCACCACCAGGAGCTGTACCCACCACCGCCTCCGCGCCCTATCTACCCTGAGC GCCAGTATAGCTGCACCAGTCTCCAGGGGCCGGGCAATTCGCGAGGCCACGGGCCGGCCC AGGCGGGCCACCACCACCCCGAGAAATCACAGCCGCTCTGCGAGCCGGCGCCTCTCTCAA GCGCCTCCGCCTCCCCGTCCCCAGCCCCGCCAGCCTGCAGCCAGCCAGCCCCTGACCATCC CTCCAGCGCCGCCAGCAAGCATCCATAGTCTACCATGGGATGAAAAAATCCACGTTGCAC

GGTGTACCCCATTTACGTTAGGGGAACCNACGCTCGAGACGCCTAACCGCAGCAGTCTGT ATTAAGAAGAGATTATTACATCGTACTGACGAGAGAGAGGAGATGGCCATGTGG

>'000127a-021.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-021.scf'(38>612)

CTGCAGTTGGCCCCTACTGGCCGGGGTGGTCTGGGGAGTGGACAGATTGAGATTGTGTTG GCAAGTGTTTGTCTTTTCTGAATGCAATGTGGCAAAGCAGGAAAAGAGCCTAGGTTTGCA GAATATATGTGCGTGCATGCTGAGTTGCTTCAGTTGTGTGACCCCACGGACTGCAGCCCAC CAGCCCCCTCTGTCCATGGAATTCTACAGGCAGGAATACTGGAGTGGGTTGCCTTGCCCTC CTCCAGGGATTTCCTGACCCAGGATCAAATTCACGTCTCTTACATCTCCTGCACTGGCAAG

ACAGTTCTTTACCACTGTCCCCACCTGGAAGCNAATATACACANGATGACAAAGCTCAAA CTCATTCTGACCCCACACCTCTGTCTGTTCTAGTCCCACACGAGCTTGCTCTTTCTACTGNG NGNCCACTAAACGACTGTTCTNCTGTGCGCTTACTCACAGTATGGNNCTATCANAGTCACT GTTGCTTTGATGCTAGTCACATAACCTGGACTTCTACCTTTTATGTTTGTITITTTAT ACTAACTGATTTTTTTTTTTTNTTATC

>'000127a-065.scf came from CONTIG 19 at offset 537;"E:\SEQUENCE\export\EST_db\000127a\000127a-065.scf'(46>576) CCTGGCCTTCATCTGTCTTGATTGACATCTTTGCTTTCTTCTGTCCCCTTCACTCCAGATCCC TAAGTTCCCTTCCAGCTTGGGGACTCAGGGTGGGATGTGGTGTGGAGGAGAAGCCCCAGG CCCAAAATTCCATCTATTCTTCCTGGATCCCAGAGGGTGGGGTAGAGAAGAGGGGGGNCA TCCCCAGCCCCCCAGCACTGAGGAAGAATGGGGCTCTTAAGGCCTTAGCTCTGATCCCTTC

CCCCTTCTCCCTGCCCCCAGNACTGNGCCACTTCTGAGTTGGGCAGCGGGTTCTAGCTCAG CTCAGCTGAGAATGTTAGAAACTACAACATAATTCTATTAATTAGTTTTGTGTCTTCAAAA AAAAAAAAAAAAAAAAAAAAAACTGAGGGGGCCCCGTACCCATCGCCTATGGATCGTAT ACATTCCGGCGNCGTTACAGCCGGACTGAAAACTGNCGTACC

>'000127a-022.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-022.scf'(48>664)

TTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAACAGGAAGCCTTGCCTGATGA GACAGAAGTGGTGGAAGAAACCGTGGCCGAGGTGGCCGAGGTACCCGTGGGAGCCAACC CCGTCCAGGTGGAAGTAGGAGAATTCGATGATGGTGCTGAGGAAACCGAAGAGGAGGTG

GTGGCCGAGAACCCCTGCCAGAACCACCACTGCAAACACGGCAAGGTGTGCGAACTGGA CGAGAACAACACCCCCATGTGTGTGTGCCAGGACCCCACCAGCTGCCCTGCCCCCATCGG CGAGTTTGAGAAGGTGTGCAGCAACGACAACAAGACCTTCGACTCTTTCTGCCACTTCTTT GCCACCAAGTGCACACTGGAGGGCACCATGAAGGGGCACATACTCCTACTGGACTACATC GGGCCTTTGCAATACATCCCNCCTGCCTGGACTCGANTGATGTATTCCCTTGGCATGCGGA

TGGCTAGTACGTCTGTCAGCTGTACGAAGGAGAGGACACACTCTGACGATACAGAGCTGG AGAAAGATCACGAATGAACGCCGGGCGGGACATCTGGATGCGNCGGATNGAAAATAACA GACTTTCTGCCGGAACGG >'000127a-023.scf came from CONTIG 21 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-023.scf'(45>583)

CTGGGGGGAAGACCATGGACTTCGTCGACGTGAATGAGAGCAACGCACGCTGGGTGCAG GACTTCCGCCTCAAAGCTTACGCCAGCCCCGCCAAGCTGGAGTCCATTGACGGTGCCCGCT ACCACGCCCTGCTGATCCCCAGCTGTCCCGGGGCCCTGGTGGACCTGGCCAGCAGCGGGT CCCTGGCTCGCATCTTGCAGCACTTCCACTCTGAGAGCAAACCCATCTGCGCTGTGGGCCA

CGGCGTGGCCGCCCTCTGCTGCGCCACTAGTGAGGACAGGGTCTGGGTGTTCCAAGGCTA CAGCGTCACCGGGCCCTCAGTGTACGAGCTCGTGCGGGCGCCCGGTTTCGCCCACCTGCCC CNTGATGTGGAGACTTCGTGTAGGACGCGGGGNCCTGCTTCAGCGCCAGCGACCTGACGC ATGCATGTGTGCTGGATCGCCACCTGGTCACGGNCAGACGCCAGCTCACATTCTGNCGTG CAAANCTGTCTTNCTTGTGCAGCGNAAGGAGNAGNCCCNGGCAGCCCCGACAATGCA

>'000127a-024.scf came from CONTIG 22 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-024.scf'(54>633)

GCACGAGGGAGGTCACCCACATCCCTTCAAGATGAAAGCCGGGTGCTGACCTTGGCTGTG CTCTTCCTGACGGGGAGCCAGGCTCGGCATTTCTGGCAGCAAGATGACCCCCAGTCATCCT

GGGATCGGGTGAAGGATTTTGCCACCGTGTATGTGGAAGCAATCAAGGATAGTGGCAGAG ACTATGTGGCCCAATTCGAAGCCTCCGCTTTGGGAAAACAGCTCAACCTGAAACTCCTGG ACAACTGNGACACCCTGGCCAGCACGTTGTCCAAAGTGCGTGAACAGCTNGGCCCAGTGA CCCCAGAGNNTCTGGACAACCTGNAAAAAGAGACCGCGTCGCTGAAGCAGGAGATGCAC AAGGACCTGAGGAGGTGAGCAGAAGTGCAGCCCTACTGTACGAGTTCAAAAGAGGGCAG

AGGAGTGGAGACTACGNCAGAGTGGCGCGCTGCGNNAGAGTCGGAGGGCGCGCAAAGTG CAGAGTGAGACAGTGACCGTGCCAGACTCGCACGCGCCGCCCGAAACTGGCAGAGTGCG CTACGACACTGCAGGTGCGCCGCGGGGCTAAGGGGGGGCGGGA >'000127a-025.scf came from CONTIG 23 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-025.scf'(47>576) TTTTTTTTTTCCAGTTGGATAAATCATGAGA

ATAACAAACGTCACTTTCTGGAGAGTCATCTTATTATAAATACATCAAGTGCACTTAATAC AATGAAACTCGTCTTTTGGTACCACTGTGAGACCATCAGGTGAGGCTTTGTTAAATTTCCC TCTAAACTTAGGCTGAGATGATCTCAATTCAGGAGGGTCATAGCAAACTTTTTCCAAAACT

ACAGCGAAGAAGCTGTAACAACACCCGCGCCCTCCCAATGACAACGCNGTAGAGAAAGT TACTTTGCCCCACTNACCCGGGCCCTACCCGCTCTGGCACGTGAGATTCAGCAGCAGGAG ACGAGCGCCACAGCGTGTGCAGGCCAGACCCGGTCACTGTACTCAGNCCTGACCACAAAT ATCCTATCAACGAAGTCTAAGGTAAAGAACTAACAGGGGCTCTGTCTACAAGCTTGCTCT CAATGAAACCCGNCTTTATAACTGGTACAAGGACTCACTTGGTGTT

>'000127a-028.scf came from CONTIG 24 at offset 0;"E:\SEQUENCE\export EST_db\000127a\000127a-028.scf'(53>645)

GCACGAGGGGAGGTTGGACGCTGTGCACCCTCCTCCCCTCCTCTCGCCGGCAACGTCTGA ATCCGGACACCATGGACTCGGTTCGCCCCCTCTGGCTGATGCTTCTGTCGCTGCTCCTCGT GGGAACTGCGCTGGGTGATGCCTCGCAGGCGCCGCCAGGAAATAACGCGGAGATCTGCCT CCTGCCCCCGGACGACGGGCCCTGCCGGGCGCGGATCCCCAGTTACTACTACGACAGGTA CACGCAGAGCTGCCGCGAGTTCATGTACGGAGGCTGCGAGGGCAATGCCAACAATTTTGA

AACTTTGGAGGGCCTGCACGAAGCGNGCTGGAAGATTGAGAAAGTTCCCAAAATTGCCGG NTAAAAGNGAATAGTAGCAGTGTGGGGAGCTCAGAGACAGTATTCTTCATCTAGTTCTTG ACATGTAATAGTTATATTGCGGTGTCACACATGAGACCGGTCCGGTGAGCTACTGTATGAC TCTGGCACCAAGAGACTCATATTTGCTACACCCAAGAGAGGCTGTGTTGCTAGTCCTCGTA TATTTTACCANAACAAGCTGAGGCTCACTACGTGNGAGGAGNATAATTGC

>'000127a-029.scf came from CONTIG 25 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-029.scf'(49>593)

GCACGAGGCAATACACTAGGTAATACTGTTTTAGGTTTCCCTTTTTCCCTCTTTATCTGAAA GTATCCTTGGTGTACGGCGTCGTGTCAGCTTCAGAATACTGGGTGCTCGTCACCTGTACAC

ACGCACAACCTGTGGTTTCTCAGGGTCTTCAGCGGGATAGCTTGGGGCACCGTGTTCACTG GCGTTCTCTCGCTGCCTACGGTGGGTTCTTGTTGATTAGAGAATCTAATAGTTTATGTATGT GAATCCCAACCTTTTCAGGTACCCGCCCACTGTATTGTACTATACTTCCTTTCGTTTTCTTT CTCCCTCACTGAGCCTGTTTCTCTTTGAAGTTCACATTTCACACTATTTAGATCACACATGT TACGAATATCACGTAATATTGTCTGTCTGTATCTGTATTAGATGGTTCGTGGGATCCTCTG

GGTCCATTCACTAGCTGCATGTACATTTTTCTTGTTNCATGNTGAGTATGTATTCATATATT GTTCACGATTTTACAGTTATTGTCTTGTATTTTTATTTTCTGTTATATGATG

>'000127a-030.scf came from CONTIG 26 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-030.scf'(53>583)

GCACGAGGATGGGAGTAGACATCCGCCACAACAAGGACCGAAAGGGTCGACGACAGGAG CCGAAGAGCCAGGACATTTACCTGAGGCTGTTGGGCAAGCTGTATAGGGTCCTGGCCAGA CGAACCAACTCCACCTTCAATCAGGTTGCCCTCAAGAGATTGTTCATGAGCCGGACCAAC AGGCCACCGCTCTCTCTTTCCCGGATGATCCGGAAGATGAAGATGCCTGGCCGGGAGGGC AAAACAGCTGTGGGCGGGGGGACTATAACCGAAGATGTTCGTGTGCAGGAGGTGCCGCA

ACTGAAGGTGTNGTGCTTGCGAGAGAGCAGACGCGCCCGCAGCCGGATACTCAAGCCGG GGGCAAGAGCTCACCTCGATCAGCGGGCCTGGACTCCGCCAGGGCTGTGCACTGCCTCCT TCTGTCCTCGTAGGTCGGAGAGGTCAGGCTTCCNCAGGGCCCACTACCCGATAGCCACAC AACCTACTCGCTCAAGGCGGNAGTGAGCGGCAAGCGCGAGCCTCGGCTCATACT

>'000127a-031.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-031.scf'(47>393)

CTTCGTTTTCTGAATGTTGAGCTTTAAGCCAACTTTTTCCCTCTCCTCTTTCACTTTCATCA^ GAGGCTTΓTTAGTTCCTCTTCACTTTCTGCCATAAGGGAGGNGATCATCTGCATATATGAG GTTATTGATATTTCTCCTGGCAATCTTGATTCCAGCTTGTGCTTCTTCCAGCCCAGCGGTTC

TCATGATGTACTCTGCATATAAGATAAATAAACAGGGNGACAATATACAGCCTTGACGTA CTCCTTTTCCTATTTGGAACCACGCTGTTGCTTCATGTCCAGGTCTTACTGTTGCGTCCTGA CCTGCATACACGATTCTCAAGAGCAATCAAGGGNGCCGG >'000127a-032.scf came from CONTIG 28 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-032.scf'(53>635)

GCACGAGGCTTTTCTCCAATCATAAACCACGTGGCCAGGGTTGCCGCTGCAGCCACACAG CAACGGACAGCCTCTCAATACTTTGTGCTCTTGATCATTACTGATGGCGTGATCACAGACC TCGATGAGACCAGACAGGCGATTGTTAATGCTGCCAAGCTGCCTATGTCCATCATCATCGT CGGCGTTGGAGGCGCGGACTTCGGCGCCATGGAGTTCCTAGATGGCGACGGCGGAAGCCT

CCGCTCCCCGACCGGCGAAGAAGCCGCCAGGGATATTGTNCAGATTGTGCCTTTCAGGCA GCTCCAGAACGCTCCAAAAGAAAGCACTGCTCAAAGCGNCCTGGCGGNAGGCCCCCAGC AAGGGANGGGGCTACTTCATCACATACAAACTCCTTTCTCCCCAGAACCCGGCTTCGAAA TGAGAGCGCCCTGGTCGTCGAGCAGATTTGTGTGCTGGTGGAGCACAGATTCTCACATCTC AATGCGATTGTCATTTCACCTCTCAAANCCTACATTACATGCACCTACTTCTTGGATTGTCA TTAAGCTTCTTTTACTGTTTGAGAAGGCTACTTAGTTGC

>'000127a-033.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-033.scf'(48>605)

CTAGTGGTTATTAAGACTTTCGGGGCTGATTTTAACCCTAACTCTCCCTTCAGTTGGCAGC CCAAGTGCTAGAAGACAAGGGTGTTGGCTTCGGGATGGTGGACTCTGAGAAGGACGCGGC TGTAGCCAAGAAGCTAGGACTGACTGAAGAGGACAGCGTTTATGTTTTCAAGGGGGATGA AGTCATTGAGTACGATGGCGAGTTTTCTGCTGACACCCTGGTGGAGTTTCTGCTTGATGTC CTAGAGGACCCTGTGGAATTGATTGGAGGTGAACGAGAGCTGCAGGCATTTGAGAATATT

GAAGATGATAACAANACTATTGGCTACTTCAAGAACAAGACTCANAACATTACAAAGCCT NATGAGACGCCGCGGNAGATGTTCACCCCTACATNCCTTNNCTCNNCCCTNCGACGCAAG TGGCAAAGTAGCTGACCCTAAGCTGATGAATTGATTCTACGAGCCTCATGGNAGANCTGT GACATCCCAACAGCCCACAGCGAAGAAACGCAGCTCGTNAGCACCAGAAACAACTGAGA GTGAGCTGAATTGATGT

>'000127a-034.scf came from CONTIG 30 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-034.scf'(47>553)

CTGCTTGGCAGTTTGATTTTTAAATTGTGTTAGAACATAAGCTGTTTCAGAAAAATATGAA AAATGTATGGCTGCCTTTTGAAATATTTGATGCCTTGTCCTACAGGATACTGCAAAGAACA

TGGCTGTCCTAAAATTGTAAAAATTGTATAAACAAGTCACAAATGCCAGTTTTCTAAAAAC TTTTCAGATTTTTCCCTTGATATGAAGGTAAGGAACATATACAGGTATGGAGTATTTGACT GAAAACAGTGTAGGTTATGGTGGAGACACAGACACAGAATTTTCAGAGATTTGCTAGTGG TAGGTACTGAANTGAATACCCNNAGTAGCTGTAATGTCCCCTGAGACAGGTAGTCTTTCAT ACTAACACAGAGACTTTGTTGGNTCATTATAACACATGCGATGTNGTAAATGTGNTCAGG

GAGAAGNTAGGAACTTGNATGATTTGGACAAGAGTTGAAAGGATATCATAGNTAGAGGA GGNTGAAANTACTGNAAGTTGNT

>'000127a-035.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-035.scf'(48>603)

CAGGTGGCACAGCCCGCCATCACCGACAACAAGGATGGCACTGTGACTGTGCGCTACGCC CCCAGTGAAGCCGGCCTGCACGAGATGGATATCCGCTATGACAACATGCACATCCCAGGC AGCCCCCTACAGTTCTACGTGGATTATGTCAACTGTGGCCATGTCACAGCCTATGGGCCAG GCCTCACCCATGGGGTGGTGAATAAGCCCGCTATCTTCACCGTCAACACCAAGGATGCGG GCGAGGGGGGCTTGTCCCTGGCCATTGNAGGCCCCTNCAAGCAGAGATCAGCTGCACCGA

CAACCANGATGNGACGNGCAGNNGTCTCCTACTNGCCGTGTTACCTGGNGACTACACATC CTGGNCAAGTACAACGACAGCATANCCGGGCAGCCCTTCACTGNCAGGTCACAGNTGACG ACTCCTGCGCATGTCCACTGAAGTGGGCTTGNCGNCGACTCCCATCACATCCGNAGACGA CTCACCTCTGACGCAAAGGNGCCCCCTCGGCGGNAAANCTGCTGTGNANCGGTGGCAGNC ACAGGGATCTATCTC

>'000127a-036.scf came from CONTIG 32 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-036.scf'(48>605)

CAAAATCCTCACCCTGCAAATGAGAATGCTGGGTGGGCACAGAAGCACGTGAGAGAAGG CAGGNGTGCGGAAGCCCACCTGGGGGCTGGGCTCCCCAGTCTGCGCACCTTCAGGCTGCT

TAACTCAAGCTTGAGTTTGTGGACCTGCTCAGTCTGCTCGACCACAACCTTTCATAGGTGA TTGCTAAGAGGGTTTTTTCTTAAAAAGAAAAAAAAAAAAAGAATATTGTCAAAAATGGTT GTTTGCACACCCTGTGAATTTTTCTTCCTTCCAAATGGAGACTCATGTTTATGACTACTATT TAAAAAGACTCCATTTAAAGCACANTTTATGAAAACAAATAANTCCATGTTTAATGTCAT GTATACTTAATATCTTCTCTACAGTAGCTCAGTTATAGAGTGTTTTTTATTACAATTATGTT

TTGTCGGAGGAAACCGCCCAGAGAGNGATCGGGACAGGAGAGNTATGTTTGTTCTAATTA TTGAGTGGGCTTATACTTCGCTGGGTTCATGTTCTTGGTGACTACAATAATTCTTCAACTAA AAAATCATTAAG >'000127a-037.scf came from CONTIG 33 at offset

0;^,,E:\SEQUENCE\export\EST_db\000127a\000127a-037.scf'(46>513)

CTGACGCTGAGCAGCGTGGTGAGATGGCTGTTAAGGATGCTCATGCCAAGCTGGCCGAGC TGGAGGCCGCTCTGAGGAACGCCAAGCAGGACATGGCGCGGCAGCTGCGCGAGTACCAG GAGCTCATGAATGTGAAGCTGGCCCTGGGACGTGGAGATTGCCACCTACAGGAAGCTGCT GGAGGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACATGAGTATCCACACCAAGA CCACCAGAGGCTACGCAGGTGGACTGACTTCGTCCTACGGGACCCCTGGCTTCAACTACA GCCTGAGCCCCGGCTCCTTCAGCCCACCAGATCCAAGCCTGTGGGTGTGAAGAAGAATGA GACCCGCGATAGGAAGACTGGGGTCGTGTTCTCTGATGTGCTGTGCTAGTGTATGGGCTCT GCGGNGCCTTCCATCCTCTTCGCTTCATGCTTCTTGCGAGNAGCTGGCG

>'000127a-038.scf came from CONTIG 34 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-038.scf'(l>498)

AGGGCGTTAATAGTCCGCAGATTGCAGTCAAACACCCGCTCACGACCGACCCTGTCTCCG CTCGCGCCCATCTACACAAGGCCCCGTGGAACAAGGTTCGCAGGCTGGGGGTCCCCCCTC

CTGAAGGACAACGTCTCCTACACGGGCAGGCCTTTGGTGCTGTATCACTGACTGAGAGCA GAGCCTCCTGAGAGCCTGAGCTCGTCCTGCACTCCCACCCCATCCCNACCAGGCGGCCCG GCTCCTCCAGTGCAGATGGCACAGGGGGTGGACAGCTCTCCTCCAGTGCCCGGGACCTGC ACCCACCACGNNGCTGGAGCTGGGGCAGATGGNGACAGCGACCCTGCGCACTGCAGGGA TCTACGACTGTNCTGGGCTCAGGCTGGGCACTGGCCTTTGTNCAAGNATATTATAATCAGC

TGTGCTCCCAAAAAAAAAAAAAAATAAAAAAANAAAAAAAAAAAAAAATGAGGGGGCC GTACCCATCCCTAAGGTGTA

>'000127a-039.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-039.scf ' (54>514)

GCACGAGGGAAACAGTGAAAATAGCTCTGCTGTGTGCTGGAGCTCAGGAGTTTTGCCAAA

ACAATCTGGGCCTACATAAGATTTGGAAATTATCTGTCTATGGTGAGACCTGAAAGGAGT

GATTTAGACAAGAAACAATGTTCCATTCAGCAATATTCCCAAAAGGAAACTTCACCCCTTC AGTGCTAAATACTGTTACTCAAGTTTAAATGCCACCACTCAAGGAAAGAGAAACTATNGA

AGAAATAATTAT1TAATATANTTGCAGTTGGGGGAGAAGAAATAATACATTTAGNGTATT AATTCATATGCTAGGAAGTGCATCTAGAATTTATGGGATGTTGATGGNAGAGTTGTGCTG GTACTGAAGATACAACTTTNTTTGTTTTATTTGGNGTA >'000127a-040.scf came from CONTIG 36 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-040.scf'(53>617)

GCACGAGGACGGCAGTCGCTAGCCCCTCACCACCTCCATCCTGACTCCTGACCTGTAGGTT GGGCACCACCATCAGAGCCACCTCCCAGTGCTGACCCCTCCCCTCAGCAGCCCTGTAACA AGTGCCTTGTAAGAAAAGCGGGGGAAGTGGGAGCAGCCACGTTAGTCTCTGGAGGTAGGT TATCCCTGGGAGACTTGAAGGCTGGGTTTGATTAAGAAAACTCTTCCACCCCCCACAACTA

CTTCCGGACTAAGGAATTAGGGGAGCATCCGTTCAGAAGCCTGAGAAGTTATCCTATGCT GATGGAGGAGCCATGCTGCTTCATCCTGCGTGAATGCAGNTGGCTCTCCTTGCTGCTGNGA TCACCCCAGCAGACCCATAGCCCCCCAGCCTGGTGCTGGCTGCTCCAGCCCACCATGGTAC ATGGCTCCCCATACATAGCTCATTCCCANCATGNNAGAAGCCNAGTGCGNAGNTCTGNGT ATGTNATCACCAGCCTTGNCTGCTTCGGGCTCACAGCACGGAGGAACACCCGCTTCTCCAC

CTACTTGTTGATCTAAAAGA

>'000127a-041.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-041.scf'(52>584) GCACGAGGGCAGCAGCTGGGGGCCGGCAGTTGCCTTGGGGACCGCGGGCCCCTCCCTCCT

CCTCTCCCCTGCCCCTCGCGTACCCCACCGAGGCGCGGCCGACTCCCCGGCCTCCCTGCCG CCGGCTCGGCGGAGCCGCAGCGGCGCCCCGCGAGAGGCGGAGCCGCTCCCAAGATGTCG CAGACGGCCATGTCCGAGACCTACGATTTTTTGTTTAAATTCTTGGTTATTGGAAATGCAG GAACTGGCAAGTCTTGCTTGCTTCATCAGTTTATTGAAAAAAAAATCANAGATGACTCAN ATCATACAATAGGAGTGGAATNTGGTTCAAAGATATAAATGNTGGNGGTNAATATGTAAA

GNTACAGATATGGGACACAGCAGGCCAGAACGATTCAGGTCTGTGACAAGAGCTACTACG AGTGCAGCGGGGCCTGCTGTCTACACATTACCAGCGAAAACTACATGCGCTACTAATGNT TACAGATGCCGATGCTGCGAGCCAAACACGNCTCATCCCTGCGGAACACAAG >'000127a-042.scf came from CONTIG 38 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-042.scf'(48>516)

TTTGAGAAACCTCTGCGCCATGAGAGCGAAGTGGAGGAAGAAGCGAATGCGCAGGCTGA AGCGCAAAAGAAGAAAGATGAGGCAGAGGTCCAAGTAAACTTGTACACCCATGGAAGCC ACAGAAGCAGAAACAAGGGAAGCCAGAGGCCAGGGACGCTGGTACAAAGTGTGGACTGC ATGCCTACTATCTAGAACTTATCAATGGATCTGGAACATCTATGGCCATTCTGATCACCTT GACCACCTTTGCGAGACCTACCTTGCTCATATCAAAGCCGTCCCTTTTGGTCCATTGCCCT GGACCTGTGATAACTATGGACTAGTTCTCTCTCAGTTGTGGCTGAATGTAACGNGTACAAT AAATCATCTNCTTTGCTGTCTTATCGGAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAACTGAGGGGGCCGGNACCNATCGNCCTATG

>'000127a-043.scf came from CONTIG 39 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-043.scf'(52>491)

GCACGAGGCCCCACTCTCCCCCGCCCCGCTCTTTTTTAAACATGTGATTTGTGTATTGGCCT GAGCTGAGCCTTCATCGCAGTGTGTGGGCTTGCTCTAATTGCAGCTCTCAGTCTTCTCTTGT

GGAGCACGGGCTCCGGAGCGCATGGACTCAGTAGTTGCAGCTCGAAACTCTTGTTGTCAC AAGCTGGCTTAATTACCATGTGCCATGTGGAATGTTAGCTCCCCACCACGGGTCTAACCCG CGCCTGCGTTGGAAGGCAGATTCTTAACCATTTGGCCACCATCGCAATATCANGGCCTGCC TCTGCTAACCACACTCCATACATCCCTTCTTNCTCCGCTCCNNCCTGCACGTATCTGTCTCT TGTCTGGATGCTGTTTCTAGTAGTTCGTTTGGCCTGTGTTTTTCCATCTCTTATGTTGTTGTT

TGCTCNNTC

>'000127a-044.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-044.scf'(50>491) GCACGAGGAGGCCTCGCTCTTTCCTCGCGAACAAGCATCATGAGCTTCAACACCCAATCC

ACCTTCTCCAACTACCGGTCCCTGGGCTCCGTGCAGTCGTCGGGCCACCGGGTCCGACCGG TCAGCAGCGCGGCCAGCGTCTATGCAGGCGCCGGGGGCTCGGGCTCCCGGATCTCCGTGT CCCGCACCACCAGCGTCCGGAGCGGCTGTGGGGTACGGGAACCTGCGCGCCGAGATGGCC GAAGGTCTGGTGGGTGTAGAGGGCATCCATGACGAAAAGGAGAACCATGCAAACTGAAA TGACCGCTGTCCTCTACTAGAGAAGANNGAGAGCTGCATGCGATATCGCAACTGCAGACA

AATCCGGTACACTGTAGAGATGTACTCAGTCATTAATGGCGCATACTGTATATATTTAGTC TGGGCTAATTTGATTTTTTGT

>'O00127a-O88.scf came from CONTIG 40 at offset 24;"E:\SEQUENCE\export\EST_db\000127a\000127a-088.scf'(50>618)

TCGCGAACAAGCATCATGAGCTTCAGCACCCAATCCACCTTCTCCAACTACCGGTCCCTGG GCTCCGTGCAGTCGTCGGGCCACCGGGTCCGACCGGTCAGCAGCGCGGCCAGCGTCTATG CAGGCGCCGGGGGCTCGGGCTCCCGGATCTCCGTGTCCCGCACCACCAGCGTCCGGGGCG GCTGGGGGTCCGGGAACCTGGGCGCCGGGATGGCCGGGGGTCTGGTGGGTGTAGGGGGC ATCCAGGGCGAGAAGGAGACCATGCAAGACCTGAATGACCGCCTGGCCTCCTACCTGGAG

AANGTNGAGAGCCTGGAGGCGGATAACCGNAGACTGGAGAGCAAAATCCGGGAACACCT GGAGAAGAAGAACCCCAGTCAGAGACTGGGCGCATTACTGTAGATCATCGAGGACTGAG GCTCATATTTTGCAATTCTGGGACACGCCGCATCGTCTGCAGATGATATGNCCGTCTGCTG CTNTGACTCAGAGTCAGTATGAAAGACTGCCTGCGCAGCTGGGAGAGGACTACCGGCTCG CAGTCATGTGACACATGTCACGCTGCGTGA

>'000127a-045.scf came from CONTIG 41 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-045.scf'(52>359)

GCACGAGGCAATCTTTCGCCATCCTAGCCGAGAGGGTATCAAGTCGACATCTGCAGGAGT CAGACACGCTCGGGGCCTACTGAGAAGCCTCCCAGACGCTTCATTTCTCTCTCTTGGGTTT

ACGGTAGGGCACGAAGAGGGTGAGCTGAAAGGTTGTAGAAGCTCCAGTTGCTCGCCACCC TCCTGGACTGNAGAAACAGGNCCCTTCCAGGGATTCGTAGCGGACTAGTGGAGCCGCAGG NACTAAAGCGGCGGCGCGCGCTCCGNAATCCCNNATCTGGGTCCANAATACACANCTANA TNNGCTT

>'000127a-046.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-046.scf'(48>562)

CGGCGGCGATTGTGGTGACTGAGCGGAGCCCAGCGACAGGATGGCTGGGCACAGATTGGT GTTGGTATTAGGAGACCTGCACATCCCACATCGGCGCAACAGTTTGCCAGCTAAGTTCAA AAAGCTGCTGGTGCCAGGGAAGATTCAGCACATTCTCTGCACTGGAAACCTTTGCACCAA

AGAGAGTTATGACTATCTCAAGACTCTGGCTGGCGATGTCCATATTGTGAGAGGAGACTT CGATGAGAATCTGAATTATCCAGAGCAGAAAGNTGTGACTGTTGGGCCAGTCANAATGCT CTGATCCATGGACATCAGTTATTCATGGNGAGATATGCCCAGCTAGCCCTATTGCAAGCA GTNGATGGGACATTCTTATTCAGACATACCATAATTTGTAGCATTGGCTGNAATTATTCTC TTATTCCGTTCTGCCCTGAGCTATATGTCTTGGNNACACATATTCTCTTTGGTGAGTATTCA GCTTACGTGTCTTTGTGTTATATGGAGAGAAA

>'000127a-048.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-048.scf'(54>584)

GCACGAGGGTTGATAAGGCATCTACGTTTTAGAAGCTCTGGCCACTAGTCGTTAAGATGA TGGCTCTGATGGCATTTCTATGGATTATAACGAGTCATCTGTGAGAGAGAGTCACTCTGGA CAGGCTTGTTACCCTGACTGACCCAGAGGTCCTGGGGGGAATGGCACCTTGTCCTCGCTCT TAAGAGAACCTGTGGAAGGAAACACAGAGTAAACGTGGCTGCCGTTTCACAACTGTGGAA GGAAATGTGTGAGCGAATGAAGGATCTTAGAATTCAAAGTAGAGGGAAGCCCACCTTGTC

TACTGATTTTGATGTATATTCACAGCGTCCTTTTAAGATCTGNGAATGAGACTCTTCTAAN CTCTATACTCTTGCACTCTAACGCAGATCACAGTCTTATATAACTATTTATCNANNNAAGT ATCATTCTAAGATGTTNTTTNGGAAAACTGTAGAATGTAATGTACTATGAACTGATATCTG TCAAGTATTTATATAATACTGTTTANTTTACTGTTTTGGTGATCTA

>'000127a-049.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-049.scf'(53>599)

GCACGAGGGCACAACACTGAGAAAACTAGGGAAGACTCAGGCTCAGAGCATGGTTCCTG TGTCCAGGATAGTCACAGTATTGTTCAAATAAAGAAGCTTCCTGGCAAGTCAGTCTTTTAG AACTAGTATCCTATGTATCCTTCGTTGATTTTCAACACTTCTGAAGTCTCCCTCTATTAGTC

TTCTCCCCAAGGGACATTTATGAGAAGACTCCTGGAGAAAAATCTGTTTAAAATATGTGCT CTGTTTGCTGTGAATTCCAGCTGCTGTGACTTGATCACTTACACAGGATGTCAGTTCTCCCT TCTTCTGTAGCAATCTANAGGGTTGGNACAGNAAATGGAATAAGGGCAGATGAAAGGCA CTTCAGAGATGGAGCATCTTTAAGGTATTTACATACCATTATTGGGACACTATCAGCAGGT GGGGCTGACAGAATTTTACCTTNCATGGGTCTNCATCACACCCCNCTATCCCATCCTCTNC

ATGGAANTACATATAACTAAATCAAAGAGAGCTTAAATCTCAAAGAGCTATACTTTATTA T

>'000127a-050.scf came from CONTIG 45 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-050.scf'(52>430)

GCACGAGGCCCACCCCCAACCTGCGGGCACACTTTGAGGAGGAGGCGAGGGTGGCCGGG CTGGGCTGGAAGGTGAGGCTGGACTCCTGGTAAGTGTCAGGCTCCCTGGCACAGGGCTTC CCTGTGTTGTATAATCAGCTGTCACTTCAGCATTTCCCTGCACCGTGCTTCACAAGTACAG ATCGAACATTAAACAAACAGTGACTGCTTTATAAATATTTAACTCCCACTGTTTAGGAATT GCTTTGAGGCAGAGACAAAATAAGAGTTCCTGGCGGGCTGCTGCATGGCCCCTCTTTAGT

GGCTTTGNATTGTGAAGACAGGNTGTTNNGNAGTTTGAAGGGCAGCTGTATTCTGAAAGC CCTTTGTCCATAGGCTTT

>'000127a-051.scf came from CONTIG 46 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-051.scf '(43>355)

TTAAAGTTGATAAAGAAAAGTGGTTGTATCGAACTCCTCTACAGATGTGAAGGAATCAAG TACTAGTCAAGCAAATTTTCTGCAGATTATCACAAATCCATGAGCTGAGTGACTGTGGCTT GCAAAATCATTGTCTCTGGGTCTGATGTAGTTCCTTTCCTCCCCAATTTCGAACTAGTGAA GAGAAATTAGTCATCAAACTATGAANTTACTGTGTAAAAGAAAAAGTGATTNNGTGATGC TGAGGTGATTCAAGGTCTTGCTACAGAAGTATTAATCACCCCTGTGCTAGAATGCTCTTAT

GNNGTAGNTC

>'000127a-052.scf came from CONTIG 47 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-052.scf'(48>395) CTTAGTGGATCTTTCTTGTGGCGTGCCTCTTTCTGCTCTATGCGTGCTGAAGGCCGTCATTC

ACCTATGCCGAGCTAAATTTTCTGCCAATTATCACAAAGCCATGAACTGTGTGACTGCGCG GTGGCAAAAGCGTTGTCCTCTGGGTGCTGCTGTCCCTTCACTTTCCGTCCCCTCTGTGCGTA CTATCGAAAGAGAAATGAGGCTGAAATCTATGAAGTACTGGGTGAAAGAAAAAGGTGAG AGGTTGAAGCTGAAGTGACCATGATCTCGCTTACAGAAGAATTAAGGCACCCCCGTGCTA GATAAGCATGATAATGAGAAGCCCTTTGCATAACCAAGAAGACT

>'000127a-053.scf came from CONTIG 48 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-053.scf'(49>527) CAGAGGTGCAACTTTCTTCGGTCGTCCCGAATCCGGGTTCATCCGACACCAGCCGCCTCCA CCATGCCGCCTAAGTTCGACCCCAACGAGATAAAAGTCGTGTACCTGAGGTGCACCGGTG GGGAAGTCGGTGCCACGTCTGCCCTGGCCCCCAAGATCGGCCCTCTGGGTCTGTCTCCAAA AAAGGTCGGTGATGACATCGCCAAGGCAACTGGTGATTGGAAGGGTCTGAGGATTACAGT GAAACTGACCATTCAGAACAGACAAGCCCAATTGAGGNGGTACCTTCTGCTTCTGCCCTG

ATCATCANAGCCCTCAAGGAACCCACCAGGNACAGANAGAAGCAGAANAACATTAAGCA CAGGGAANACATTACTTTTGATNNGAGATCGTCACATTTGCCGGNCAGATGCGCATTCGG TCTCTAGCTAGAGATCTTTCTGGANCATTTAGAGATNCTGNNGACGNCCACCTGTGGN >'000127a-055.scf came from CONTIG 49 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-055.scf'(48>610)

TTCCCAGGTGCTGCTGGCCGAGTCGGTCCCCCCGGCCCCTCTGGAAATGCTGGACCCCCTG GCCCTCCTGGCCCTGCTGGCAAAGAAAGCAGCAAAGGCCCCCGCGGTGAGACTGGCCCCG CTGAGCGTCCCGGTGAAGTCGGTCCCCCTGGTCCCCCTGACCCCGCTGGTGAGAAAGGAG CCTCTGGTGCTGACGGACCTGCTGGAGCTTCTGGCACTCCTGGACCTCAAGTATTGCTGGA

CACGTGATGTGTTCGTCCTGCTGGTCAGAAAGAGAAAGAGCATCCCTGTCTTCTGCACCTC TGTGAACCAGCAAACAAGTCATCTGAGCAATAGAGAACTGCCCCCTGTCCCATGGCCCCT GATTGTTGTACCCTGTGAGTTGTACGGGAGGAGTCTGGGTGAGTACCTTGACAAATGTTTC GTGCCAGGGGAGGGGGGAACGCCTTTGACCTTGGGTTCGGCTCCGCGGCCCGCCTGCGAC TGCGCAGAGGATGGGGGACGGCTGGGCCTGGTCTTGCCGGGGCGGGCCGGGCCCAGCCCC

GGGAGGGGAAGAAAAGGAA

>'000127a-056.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-056.scf'(49>595) CTCGAGTTTTTTTTTTTTTTTTTTATTπ

TCCCATGGGCAATAAAGCGCATTCAATGTGTTTATAAGCCAAACAGTCACTTTGTTTAAGC AAACACATGTACAAAGTAAAATAAAACCACAAAATAATGAACTGCATGTTCATAACATAC AAAAATTGCTGCCTACTCAGTAGGTAACTACAACATTCCAACTCCTGAATTATATTTATAA ATTTACATTNTCAGTTTAAAAAAATAGACTTTTC^ TTACATTCTGGAGAACTGGAGCTCAAGCTCAGCCCCCTTCCTTGTTTTGCTCCCAAAGCCT

CCCCCCGATCACCACTCCCTTGCCCCCTTNAGCTAGAGGTGAGCACATCCCTCACAATTGC ACTGTCAGNCCGNGTCAGCAGGNCGCATCACACAAAGGCACCCAGAGTGNAANCTTNTTA ANCAAAAGNNACAAAAAACTACTTCAAAAAAGAGAAAAACAACGNNATTGCNCTGGGA >'000127a-057.scf came from CONTIG 51 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-057.scf'(49>619)

GTGATATTCAAACGAATAGTCCGTCAACCCCAGACACTGGTTTGAAGAAATTGAGACTTG ATCATAGGACTGTATTAGTGCACAGCGCCAGCATGTATGCTAGGAGCAGTGGGAGGAGGC CAGTAGAAAGCCTTGTCATCTTTAGGGGTAGTGATGTGACTGCTATTTGGAGTGTCACTGA AAAGGAAAACTTTAGCATGCTCACTGATCTGCCTATAGCTCCAGCAACAGCTCGGATGTG

CGTTCTCCAGCCATCATGAGGCTGAGTCAAGTTCGTCTCTAAGTCAGAACAGCAGATTCAG CTATGACATTCTGATTCAAGACATTGTTCAGGAATCAGAATTCTGTCTATTAGACTGGGAC AGCTGNGGCAAGCTAAATTGCCTGTNACAAGCCAGATTTTTTTTTATTGATACTGTAATAT TGTGTGTATTATATATATTGTACGNTATCTAAGTTATTAAAAGTGTTGTGCTTTTTGNTTTG TTTTTATGCTTGATATTCAGAGTTAGCTCATTTGACACATAGTAGACGAAGCTGTTGATAT

CAAGCAGATGAATCAATAATTTGG

>'000127a-059.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-059.scf'(50>595) GCACGAGGCCGGTGTCCCCGCGCCAGAGACGCAGCAGCGCTCCCTCTGCCCACACCCACC

GCGCCCTCGCGCTCGCCTCTCCTTCCGGAGCCAGTCCGTGCTACCGCAGTCGCCCAGTCCA CCACCACCCTCTGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGATGT TCGGCGGCCCCGGCACCGCAAGTCGGCCGAGCTCCACCCGGAGCTACGTGACCACATCCA CCCGCACCTACAGCCTGGGCAGCGCGCTGCGCCCCACCACCAGCCGCACCCTCTACACCT CGTCCCCGGTGGNCGTGTACGCCACGCGCNTCTCGGNCGTGCGCCTGCGAGCGGNCGTGC

CCGGCGTGCGGNTGCTGCAGACTCGGTGGACTTCTCGTTGGCCGACGCCATCACACCCGA GTCAAGACACCGCACAAGAGAAGTGGAGCGCAGGACTCATGACGCTCGNCACTACTGAC AGTGCGCTTCGGACACAAACAGTCTGTGCTGAGTGGCACTCAGGCAAGCAGGCGCGGGGA CTTAA >'000127a-060.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-060.scf'(l>277)

AGGGCGGTTAATAGTCCGCGAGACCGTCCCTTCTCAACCCAGTTTTGAAGAGCTCTTATCT TCAAAAAGAACTCTTACTCAAGTTTAAACATCACAGGGCTGACTACACTAGGGGGTTTTAT

TGCCTCTGTGCTTGTTCTTAAATCTGTTTTGGACGATCGCTACGAATCACTATGTCAATCAG CAAGGTGAAGAACTAAGACATGAAGGAGAACCGGATGTCCTTGTTGTTGGCCTCTCATTT TTTTGACTTGGGGAAGACGAGGTTTGGCTGGTT >'000127a-061.scf came from CONTIG 54 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-061.scf'(55>678)

GCACGAGGCTGTCACTTTGTAAAGCTTTCAATCAAAACCACCCTGAAAGCACAACAGCAG AATTCAATGATTCTGACTCTGGCATTTCACTGAACACAACAAGCTCCAAGCATGGCATCAC CAGACCACTCAGTGGAATCTTCCATCTATGGAGACACATTGCTTGGCTTCAGTGATTCTGA AATGGAAGAGATAGATAGTACCCCTGGAAATGTCAAACAGAAGGGGCCCAAAACACCGC

CAGTGTGGCCTCCTGGGGACCCAGTCCAACCTTTGTCGTCATCACAGGGGAACAGCGCTG CAGCACGCGATTCCCAGAGTGAAAACGCACCAAAGAAAGAGTACCTGTAAGTCCGGGTC ATCGAAAAACGCCATTCACATAAGACAAACATTCAGCCGCTTGGAGGCTCACCTCACAAG AAGAGAGCTACGGNNCAAAGCTCTCATATCCATTCCTGTAGAAAGACATTACCTCCAGTT GAGACTTCATGAATGAGTGCAGGAGCATTCACGAGCTCACTGCATAATTTAAACTACTAG

AGGGNAGATAAGGGCTGTCAAAATGCAAAAGAAACGGAATATAGGNACGGGCAGATTAA TATTAAAAAAAAAGAAAAAGTCAAG

>'000127a-062.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-062.scf'(47>628)

CTGACAGTGAGCCCGAGTCCGAGGTATTTGAAATCACGGACTTCACCACTGCCTCGGAAT GGGAAAGGTTTATTTCCAAAGTTGAAGAAGTTTTGAATGATTGGAAATTGATTGGAAACT CTGTGGGAAAGCCACTTGAAAAGGGTATATTTACTTCTGGGACATGGGAAGAGAAATCAG ATGAGATCTCCTTTGCAGACTTCAAGTTCTCAGTCACTCATCATTATCTTGTACAAGAATC CACTGATAAAGAAGCAAAGGATGAAGTACTAGAAGATGTTATTCCACAACCTATGCAAGA

ATTGCTGTGTATGAATAATGACTTTCCTCCCAGAGCACATTGCCTGGNAAGATGGNATGG NACTCGAGAGNTNGGGNNGATAGCACCCTGCTGCAACATGATGCTGTCCTCATGAATCTA AGTGCATCTTCTCTGACTCTGTGTCTATGGCTTGGAAACACTGCTGNCAGNGCCACTCTTG TGCAGATCTCACAATGGCGAGATGATGGGNNGAAGTCAGGNNCTGGGNNCGACTGATTG AATGGTCTCTCGAAAGGCCAATAGATACTATTTCAGNCTGT

>'000127a-063.scf came from CONTIG 56 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-063.scf'(48>639)

GAAGGATTTTCCAGTTAGTTTCTCCATGTTTGCCCGAAGCCCAAAAAGTCTCTGTCCAGTT CTTTGTTAGGACAGTAAGACCCAGTGAAGCCCAAGTTAAGTGGAAGGCCCTGAATAATTC

CAGAAGACCCATTCTTATCCTTAAAATCCTAGAGTGGTCAAGGGACAGAGTGATTTGTTTC CGAAAGAGTCCGAGGTATATGTGTTAAATTTAGAAACATTATTTTGTGCTGCGAACTCTCA TGATGTTGACCAGAAAGAAATCACTTGCATTTTATACAGTGTCAGTTTGGAAAGCTGATGA AGTTTCGCATTCTTTTTAGGAGGTCAAGAAAGGCACANNAATGCTGCTGCAGAAGGNGGN NGGNNGTCATTNTTGCCAGTTGTCTAGCTTGATTGCAGACGGTTCTGTTNAGTGTTATGGN

CGTGTATGTATCACTCATTCATGGTTGATGAGTAAATATGATGAAATGNCTGANACTGAG GCTGGNATATACAAATGCAGCTGACCTATCTCAAGACTACGTCAGCAGGTAGCAACTAAC ATATCTAGAGTATATTTGTAATTGATATGAACAGAATTACGAGTGGG >'000127a-064.scf came from CONTIG 57 at offset

0;Ε:\SEQUENCE\export\EST_db\000127a\000127a-064.scf*(50>649)

TTCCAGTCCTGTTTCCACCTACAGAGTCCCAACGTGGTTATTGCAGGCAACGTTCCCTCTCT CCGTGGTCTAGAAGCCCCTCCCCCAAGGTAGAAAGAAGGGAAGAAGCTAACTCCAGTGTT TCCGTTGCACTGATCCCCAATTCAGTCCAGGAGGGGGCTTGGTAACCCCTCTCCCTCAATA TCCTGGCACCTTGGGCTTGTGAACGCCTCCTAGCCAAATCACTAGAGTACAGTGACCCCAG

CCTCCTGCCTGTCCCGAGTGAGCCCTCCCCACCCTGACCGTGCTAACTGTGTGTACATATA TATTCTACATATATGTATATTAAACCCGCACTGCCATGTGTACCCTTTTCTGTGGTGTCTAG CATTAACTTATTGTCTAGGCCGGGCGGGGTGGNAGGNAAATGCCACAGTGAGGGNGTGGC AGAGTCAATTGCTATATATCGAAAAGAAAACTTTTTAACTTTNATTCACATGCATCTCAGA GATATTANAAGTTAGGAGGGGGAGTTTGGAGTGGGAAAAACTTAGGGAGGAGCTGCTGT GNAGAAGAACAATGCTGGAGACCTTCACCAGCACCAGCGCCTTGCCTGTGGCA

>'000127a-066.scf came from CONTIG 58 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-066.scf'(53>292)

GCACGAGGCCGGTCTCCGCGCGGGTCTGGGTCGCGGAACCCGGTGGCTGCTGTGCGGGCG TCATGTCAGACAACGAGGACAATTTTGATGGAGACGACTTTGATGACGGGAGGAGGATGA AGGGCTCGATGACTTGGAAATGCCGAGGAGGAGGGCCAGGATAACGTTGAGATTCTCCCC TTTGGAGAGCGACCGCGAGCCAACCANAAACCAATCACACACCATATATGACCACTATGA

>'000127a-068.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-068.scf'(49>600)

GCTCTTCTTTGTTTCCCAGCTACAACTTGCAGAGCCATCACATCCCAGGAACATTTAGGCA AAATATAAAGGTGTGTGTCTAAAATATGTCTTTGAAGAAGCACTTCCTCCTTCCTCAGTGC TTCTGTCCCACTTGGCTTCTGCTTGGCCACCTGGGGCTGCCGCAAAGCAGGTTAGTCCTTT

CTGGCCCTGGCTGTTGAGTGTTTTGTGTCCAAAAAGTGTTTAAGGCGCAGTGGAAGTTAAA GAAGTCTAAGACACAGTCCTTGTTCTTAAAAAGATCACCGGCAGGNTAAAANTACAGTGC TAAAATATAAGCGTATACCTGAGAAATCATTCATGTTCAGCTGTTATTGGAGTGTCTGCTA GGTGCAGACTGTAGGGTGAATTATAATAATAAGAATAGACTGNTGCTCCTCAGCAGTTCT GTCTCTCAGAGGTATCGAGTATATATCAGATAGGAATATTGGAGCCCTGCATGCCTTGCCA

TNAAGCTCAGGAGGCAGATCACGATGAAGGACGGCGAGTAGCGAGGATGCAACTTTTGN ATAACGN

>'000127a-070.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-070.scf'(48>619)

CGGCTGTGTCTTCTCTGCTCTCCCAGCCGCCGCTGCCGACCCCGCCGCCCGCCGCCCGCCG GACTCGGACGCGTGGCCGGCTGAGCCTGACCTGTGGCCTGTCCCTGGCCCTCTAGTGGAG CCTCTTCAGGCGGGAACTTCTGTCTACCTGCCCTACAGAGGAGCCATCCCACCAGCCAGAC GCTCCCAGAATCGTCACCCAGGCAGGCGGTTGGCTTGGCCCCAACCTGGGCTGGACACGT GTCCCCCGCTCCTCTCCCCGCTGGCGTTTGGCTGTCCTCCTGGGCAGCCCGTCCCCCACCC

ACTGGNCCCCAGATGGGCGAGTTTGGAGAGAAGTCGACAACATGTGGCACCGTCTGCCTC AAGTACCTGCTCTTCACCTTCTACTGCTGTTTTCTGGCTGGCTGTTCTGGCCGTCATGGCCG TGGGCATCTGGACGCTGGCCCTCAGAGCGACTACATCACCTGCTGGCCTCGGCACCTATCT GCCACACCTACTNCTGGGGNGGCGGCATGTTGTNTGGGACCGGGCCTGGCTGTTGGCACC TCAGGACGAGGACTGCTGGCGTCTTT

>'000127a-071.scf came from CONTIG 61 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-071.scf'(52>598)

GCACGAGGAGAACTTTCAGGGACCCTGTGAAGCAGCTCCAGCCGAGATGTGCGAGGAGG AGGACAGCACCGCCTTGGTGTGTGACAATGGCTCTGGGCTCTGTAAGGCCGGCTTTGCGG

GGGATGATGCTCCCAGGGCTGTTTTCCCATCTATCGTGGGACGTCCTCGACATCAGGGAGT GATGGTGGGAATGGGACAGAAAGACAGCTACGTGGGTGATGAAGCACANAGCANAAGAG GAATCCTGACCCTGAAGTACCCGATAGAGCACGGCATCATCACCAACTGNGACGACATGG AAAAGATCTGGCACCACTCTTTCTACATGAGCTTCGTGTTGCCCCTGAAGAGCATCCAACC CTTCTCACCGAGGCGCCCCTGNNACCCCAGNNCCANCGGNAGNAAATGACCAGATTATGN

TTGAGACTTTCATGTCCAGNCTGTATGTGGCTATTCAGCGNNGCTGTCCCTCTACGCCTCT GGCGCACACTGNCATGNGCTGACTTGAGAAGNGNCACCACACGGCCATCATGAGGCTCGC CTGCCC >'000127a-072.scf came from CONTIG 62 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-072.scf'(49>521)

TCTTAAACCTGAAGTGGACTACACCATCACTGTCTATGCTGCCACCGGCCGGGGGACAGC CCGGCAAGCAGCAAGCCCGTTTCCATCAATTACCGAACAGAAATTGACAAACCATCCCAG ATGCAAGTGACTGATGTGCATGGACAACAGCATTAGTGTGAGGTGGCTGACTTCAAGTTC CCCTGTTACTGGGTACAGAGTGACCACTGCTCCTAAAAATGGCCCAGGACCATCGATAAC

GACAACTGTGAGTCCAGATCAAACAGAAATGACAATTGAAGGCTTGCAGCCCACAGTGCA GTATGTGGACAGAGTCTATGCTCAAAATCAAAACGGAGAGAGTCACCCTCTGGTTCAGAC AGCGGNTACCACCATTACTGCTGCGATCCTACCTGAGTTTATTGAGTGACACCCTACCAGC TGACTGCCAGCGACGGCACGCATGTTTAGCTCATGGGTATTGGAGCCGGGGA >'000127a-073.scf came from CONTIG 63 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-073.scf'(49>374)

CGGACATTCAGACAGAACGTGCGTACCAAAAGCAACCGACCATCTTTCAAAATAAAAAGA

GGGTCCTGCTTGGAGAAACTGGCAAAGAAAAGCTCCCTCGATACTACAAGAACATTGGTC

TGGGCTTCAAGACTCCAAAGGAGGCCATCGAGGGCACCTACATTGACAAGAAATGCCCTT

TTACGGGTAATGTCTCCATTCGAGGGCGGATCCTGTCTGGCGTGGTGACCAAAATGAAGA

TGCAGAGGACCATCGTCATCCGCCGAGACTACCTTCACTACATCCGAAAGTACAANCCGC

TTGAGAAGCGCCACAGACAGGGTNCC

>'000127a-074.scf came from CONTIG 64 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-074.scf'(49>601)

AAAAAGAACCATTCGGATATATGGGAATAGTTTGGGCTATAATGTCAATCGGATTTCTAG GTTTCATCGTATGAGCCCACCATATATTCACTGTCGGAATAGACGTCGACACACGAGCCTA CTTCACATCAGCCACTATAATTATTGCTATTCCAACCGGGGTAAAAGTCTTCAGCTGATTG

GCAACACTTCATGGAGGTAATATCAAATGGTCTCCTGCTATAATGTGAGCCCTAGGCTTTA TTTTCTTATTTACAGTAGGGGGTTTAACTGGAATTGTCTTAACCAACTCTTCCCTCGATATT GGTCTTCACGACACATACTACGNTGNCGCACATTTCCACTATGTTTTATCAATAGGAGCTG NATTTGCTATATAGGGGATTTGNTCATTGATTCCACTATCTCAGGTATACTCTCACGATAC AGAGCCAAAATCACTCGCATATATTGTAGCGNCATATAACCTCTCCACACACTTCTAGACA

TTGGCTGCTCGCGAACTCGACACAGAGCTACCATAGAAACTATTTCATAGCTATCTTCCTA CCAG

>'000127a-075.scf came from CONTIG 65 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-075.scf'(55>670)

GCACGAGGGGTATCTGCTCACGCCATGAACAACTCTGGCCCCACCGCCCAGATCATTGAG CGGGAGGGCTGGAAGACCAACATGGACTTTGTTGGGCATCGGAAAGCTGTGACTGTCGTG AAATTCAACCCTAAAATCTTCAAGAAGAAGCAGAAGAATGGCAGCTCCGCGAAGCCCAG CTGCCCATACTGCTGCTGCGCCGTCGGCAGCAAGGACCGCTCGCTGTCCGTCTGGCTCACG TGCCTGAAACGGCCTTTGGTGGTCATCCACGAGCTGTTTGACAAATCCATCATGGACATCT

CCTGGACCCTGAATGGGCTGNGCATCCTGGTATGCTCCATGGACGGCTCCGTGGCCTTTCT GGACTTCTCCTAGACGAGCTGGGAGAACCCCTGAGCGAGGANAGTAGAGCCGCATCCACC ATCCACTACGGCAGAGCTGGCCTCATGACGAGCCCACTGTCACGCTGTCATGAGACCAGA AGCTGAGTACAGGCAGCGCACAGTGGACGCAGGNCCCAGNCAGGACGCGACCGGNCAGA AACGCTCGCTCCTTCGCGGGGTCAGGGGAGCTGAAATAGAAACTTGATAAAGAGGAGGA

CGAACGGGGGAAAACC

>'000127a-076.scf came from CONTIG 66 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-076.scf'(50>518) TGGAGTTCTCCCACCCACGCCGGTTCTGGCCTGCCATTGACGACGGGCTGCGGCGGGCTGC

CTATGAGCGGGGCGTCAAGGTACGCCTGCTGATCAGCTGCTGGGGACACTCTGACCCCTC AATGCGGGCCTTCCTGCTCTCCCTGGCTGCCCTGCGTGACAACCACACCCACTCCGACATC CAGGTGAAACTCTTTGTGGTCCCTGCGGACGATGCCCAGGCCCGAATCCCTTATGCCCGCG TCAACCATAACAAGTACATGGTGACTGAACGGGCCACCTACATCGGAACCTCCAACTGGT CTGGCAGCTACTTCACCGAGACGGCAGGCACCTCGCTGCTGGTGACACAGAACGGNCGNN

GTGGCCTGCGAAGCCAGCTGAGGNCCGTGTTCCGGGNTCTCCCATCCCTGTCCCTGTGCCC NCCGCTCTGTTGACCCGNTGTGATCANCAGGCTCCTNTCGCAACC

>'000127a-077.scf came from CONTIG 67 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-077.scf'(55>522)

GCACGAGGCAGTGTCTTTCGCAGGTTCGTGGTGCGGACCATGTGTGCAGTGCTGGGGCTC GTGGCCCGGCAGGAGGACTCTGGACTCCGGGATCACCGTGTCAGGGTCCTCATTTCCAAC CACGTGACACCTTTCGACCACAACATAGTCAACTTGCTCACCAGCTGTAGCACCCCTCTAC TCAATAGTCCCCCAAGCTTTGTGTGCTGGTCTCGGNGCTTTATGGAGATGGATGGTCAGGG CGAGNTGGTGGAGTCACTCAAGAGATTCTGTGCTTCAACAAGGCTTCCCCCTACCCCTCTG

CTGCTATTCCCCGAGGAAGAAGCCACCAATGGCCGGGAGGNNGCTCTGCGCTTCANTTCC TGGCCATTTTCTATTCATGATGTGGTACAGCCTCTTTACTGNCGAGTNCAGAGACCTCTTG TCTCGTGACGGTGTCAGATGCATCTGGGTCTANAATGCTGGTNT >'000127a-078.scf came from CONTIG 68 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-078.scf'(l>349)

CCCGGGGCGGCGTTAACTAGGTCCCGGCTGAGCGGGCGGGCATCCCAGAGGCCAATTTGC TGACCCTGGCCCAGAAGGCAGTGGAGCTGGCCTCGCTGCAGAACACAAAGGATGCCAGTG GCTCTGAGGAGAAGAGAAAAAGTGTGTTGGCTTCAACTACCAAGTGTGGGGTGGGAGTTT

TCTGAGCCTGCCTTANCCAAGCGAGCACGAGAGGACAGCGGGATGGTACCCCTCATCATC CCAATGTCTGTGCCTGTGCGGGCAGTGGACCCACTGANGCAGCTCAGCTGNAGGTGTGAT GAGATGAAAAGGTNCCGACAGCACCTGCTGACACAACCGTCATCATTTG >'000127a-080.scf came from CONTIG 69 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-08p.scf'(22>530)

TTACCATGGATCCTCCGGACTGCATGCAAGCTGAGTGTCTTCCCTTGCCGTCCCCGCTCGT ACAGTCTCGCTCATCTCGTTGCCGCCCAGTCCCCGCGCCCCCCGGCCGTACGAGCATCCGG CCCCCGTAGCGGACGCCATGCTGCGGGCACGCCCCGTGCTTTGGGCTGTGGTTTTGACCGC ACTGACGTTGTTCCGCGGTCCGCCGGTGGTTCGAGCTGGGGCGGGCACGATGGGCGCCGG

CCCAGTGGTGCGCTGCGAGCCGTGCGATGCGCGTGCCGTTGCCCAGTGCGCGCTGCCGCC CCCCTCCTCCCGTGCGCCGAGCTGGGCGCGAGCCGGCTGGGATGCTGTCTACGAGCGCGC TGCGCGAGGTCAGCCTGCGACGCCATCCGAGGGTGTGTTCCGGCTCGTTGTCGTCGCGCTG TGATCGCGCCCGTTCAGGTTGTGGTGGCGGGGCTCGGCCATGCGCGCGTGTGCGCTGCCTT ACCGTTCGTCGGTAGGATGCGTGG

>'000127a-081.scf came from CONTIG 70 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-081.scf'(47>636)

AATTGGCCCGAGGCGGATCGCCCCTCGACTGCAGTCTTTTTGCATCCGAGAGACCATGGTG GGCTCCCCGCGCGCCCCACTGCTCCTGCTGGCATCCCTGATCGTCGCCCTGGCCCTGGCCC

TGGCCGTGAGCCCCGCGGCAGCGCAGGGCCCTAGGAAGGGTCGCCTGCTGNGCGGCCTGA TGGAGGCGGACGTCAATGAGGAGGGCGTGCAGGAGGCGCTGTCCTTTGCGGTCAGCGAGT TCAACAAGCGGAGCAACGACGCTTACCAGAGCCGCGTGGTGCGCGTGGTGCGCGCCCGCA AGCAGGTCGTGTCAAGGATGAACTATTTCTTGGACGGGNAGCTTGGCCGGACTACATGTA CCAAGNNCCCAGCCATCTATACAGCTGTCCTTTNCATACCAGCCGCACCTGAGAGGGAAA

GCTGTGCTCTTNCAGTNTACGNCGNCCATGGATGACACATCANCTGNTGAANTNAGCTGC AGNATAACAGCAGCCACTGACCGCTTCATCTGCTCTGCGAAGCCACACTGGNGGNNGATG CTATGGCGGCCTCCCATGCGCCTGCAACAGCTCTGGCATGNTGATTGC >'000127a-084.scf came from CONTIG 71 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-084.scf'(49>316)

TTTAGGAGCCAAGGCAATTCAGCTGAACAGTAACAGTGTTCAAGCTTTGCTACTTAAGGG AGCAGCGCTTAAAAACATGGGCAGAGTCCAGGAAGCAATAATACACTTTCGGGAGGCTAT ACGTCTTGCGCCTTGTCGCTTATATTGTTATGAAGGTCTCATTGAATGTTACTTATCCTCCA ACAATATTCGTGAAGCACTGGTTATGGGCTATCATTGTTACTAAACTCTTAGAGCAAATGC

ACAAACCTTTTACCTTTACCACCGC

>'000127a-085.scf came from CONTIG 72 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-085.scf'(49>427) TGAGAGTGAAACTGCAGCCGGCGTCCAGCTCTAAGCTTCCTGCTTTCAGTCCTTTGACGCC

TCCAGCTGTGATCTCTCAGATGCTGCTGCTGGACAATCCACACAAAGAGCCCATCCGGTTA CGGTATAAGCTGACATTCAACCAGGGTGGACAGCCTTTCAGCGAAGTAGGAGAAGTGAAA GACTTTCCGGACCTGACAGTCTTGGGTGCAGCCTGACTCCTCCCATGACAGAGCTTGCCGT TCACGCTTATGCTAATGTTCCTTTTGCTGTCTAGATAGGACTGATCATGGTGATTTAGTGCA GAGTGCCAAGAGTTCTGTCCTGACATCNAGCTCTGGATGCCAGCCTCCGACTTATTTGCAN

AGTGTGTTGTGGT

>'000127a-086.scf came from CONTIG 73 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-086.scf'(49>664) TTTTTTTTTAAAAAAAGATTACAGAAAACACT^

CAGTCGTTAAGGATCTGAGAGACAGCAAGCACAACACAGTACAAAAGGAGAAGGGAATG TTGAATTCCAGTGCAAGACACTAACACAGCACAATTAGGGAACCAGGCGGAAGCAACCAT TTCACAAAGAATGGAATTAGGCATTTATACTTAATCAGGATTΓTTTTAAGCTTTAAAAGTC CAGCATAAAGAAGGGAATTGNGAAGAGTGGATGGNGACAGGGGCTAAGCTTATCTACAA TCACCATTTTACCAAAAAACACACTGGCTCAACCACGTGAGAAGNGGAGGNTAAACCTGC CTACAGAGGCCCAGCAATAGAGCAAATGCCTAGGCAGTCACATTTTTAGGTGTCGATGTC ACATTGGCTGTACATGTTTAAGGGACTTGATTCACCAGACTGGCTCCATCACCTGGCTACG AAGTTGAGTTCTTGCATTGCTCAGAGNCAAGCTTACTGNAGAGTCATCAATAGCTAGTGCT GTTTACGNCTGGGNCAAGGCTCTATAACTCACTTCTAGGAGTTTAGATACAGATTAATCAG

CACCTAGAGGAAA

>'000127a-087.scf came from CONTIG 74 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-087.scf '(50>630) CTACAACCACCTCTACCTCCAAGGCAATAGGATCAATGAGTTCTCCATCAGCAGCTTCTGC

ACCGTGGTGGATGTCATGAACTTCTCCAAGCTGCAGGTGCTGCGCCTGGATGGCAACGAG ATCAAGCGCAGCGCCATGCCCGCTGACGCGCCCCTCTGCCTGCGCCTGGCTAGCCTCATCG AGATCTGAGCGCCACTGGGCGCAGGGCCATGCCCCCACGCCTCTTTGCATTTGGCTTGATG GTTTGGTTTGGCTTTTGATGGAAGGTCTGNGACAGACCGCGTGACAGAAGNCCATGGGCT CTCTCTCTAGTCTTCTTCCCTGTAGGCAGNTNTAGGGGNAGNCAGGGAGACAGCAGCNTT

CTGCTGAAGGACATGACACGTCCGTTTCCAAGACAGAAGTGGTTGGCAGAAGGTNGTAAC CCTGAAGNCCAGNCCCCGAAACTCATACCCTCAGTCTCACAGGATCAGGGNCTGACATGN CTGAGCATAATACTGGCTTTGAGTATGCTGATTGAAGCAGACTGACGCTCCCGGGCGGCT GGCGGCGAACTTGGCCCNAGTGTGTTTAATTACCTTGC

>'000127a-089.scf came from CONTIG 75 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-089.scf'(55>387)

GCACGAGGCCCTGTACACATATCCTGAAAACTGGAGGGCCTTCAAGGCCCTCATTGCCGC TCAGTACAGCGGGGCTCAGGTCCGCGTGCTCTCCGCACCACCCCACTTCCATTTTGGCCAA ACCAACCGCACCCCCGAATTTCTCCGTAAATTTCCTGCTGGCAAGGTTCCAGCCTTTGAGG

GTGACGATGGATTCTGTGTGTTCGAGAGCAATGCCATTGCCTACTATGTGAGCAACGAGG AGTTGCGGNGAAGTACTCCCGAGGCAGCAGCACAGGTGGTGCAGGGGGTGAGCTNTGCT GATAGCGACATAGTGCCACCGCCAGCTGGGGG >'000127a-090.scf came from CONTIG 76 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-090.scf'(52>432)

GCACGAGGCACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAGGAAGGCATTCCCCC TGACCAGCAGAGGCTCATCTTTGCCGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGA TTACAACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTCCGTCTGAGGGGTGGTATGCA GATTTTCGTGGAAGACCCTGACCGGGCAGACCATCACCCTGGAAGTGGAGCCCAATGACA

CCATCGAGAACGTGATGCCAACAATCCAGATAAGAGGGCANTCCCCCCGCCANCANAGCT CATCTTTGCGGCAGCACTGGAAANAGACGACTCTTTTGATACACATCAAAANAATGACCT GCCCTGTCCTCGTGGGGGGGGT >'000127a-091.scf came from CONTIG 77 at offset

0;"EΛSEQUENCE\export\EST_db\000127a\000127a-091.scf'(52>619.)

TCCAGTTTGGTACCAATGATAAGGACTCAGACTTGTGTCTGGTTGTGAGAGAGAGTTTAAA AGCAGAGAAGGAGTTAACAGCATCAGTTACTGAGGCCATTCCCATGGCCCGAGACTGGGA GCTGCTCCCCAGTGCTTCTGCCTCAGCTGAGCCACAATCCAAGAACCTGGCTTCTGGGCAC TGTGGCCCCGAGACCAGCTCCTCAGGCCAGCGCTTGTACCCTGAGATCTTCTATGGCAGCC

CTGGGCCTCCCAGTTCTCACGTCTCAGGAGGAGCCATAGACTCTCAATTACATCCCAACAG TGGAGGCTTCCGTCCTGAGACACCCTCACTGCACTCTTACAGATCACAGCCCCTGTACCTC CCCACGGTCCCAGCCCCGCCCTCGGCACTGCTCTCAGGGNTAGCTGTACAGGGGCCATTTC TGGATTTCTNCGCACTGCAGCACAGTACTGNGTAGCTGNCGCTGNAGGGTTCTCTACCCTC ATCTTCTTCTNTACTNTCAGCTCTGACTATCCTTGGCCAACCACCTGTTCAGTTAAGCGGG

NTGCTGCTAGGTAGAGGGGG

>'000127a-092.scf came from CONTIG 78 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-092.scf'(55>563) GCACGAGGAGATGATCCAGCTGGGGAAGACGGTGCAGTACCTGCCCATCCTGTTCATTGA

CCAGCTGAGCAACCGTGTCAAGGACCTCATGGTCATCAACCGCTCCAGCACTGAGCTGCC GCTCACCGTGTCCTACGACAAGATCTCGCTGGGGCGGCTGCGCTTCTGGATCCACATGCAG GACGCCGTGTACTCACTGCAGCAGTTCGGATTCTCAGAAAAAGATGCTGACGAAGTAAAG GGGATCTTTGTCGACACCAACTTGTATTTCTTGGCGCTGACCTTTCTCGTGGCTGCATTTCA CCTACTNTNTGATTTGCTGGCGTTTAANAACGACATCAGCTTCTGCAAGAAGAAAGAGAG CATGATCGGCATGTCCACCAAAGCAGTGCTCTGGCGCTGCTCAGCACCGGGNTCTCTTCCT GTTGCTGCTGGACGACANACAGCTCTGTGNCTGNGGCCGGGGCATGNAGCCCCTCNAGCT GGAAAGGAAAAGGNCTGAGATGACG

>'000127a-093.scf came from CONTIG 79 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-093.scf'(57>347)

GCACGAGGATTCCCTGCTTCATCCTCTCACTTCCCTGGAACATTCTGGCACCTCCCTGCCCC ACTTTGGTGGGCGGCGGGTCCTCATGAACCTAGTGGGGCTCGGTGCCCCAGCCCGGGTCT GGCGGCCAGACAGAGACCCGGGACCGTCCAGCCCCTACCCTCTCCCACCTGCCTTCCTCCT

GAGGAGGGCTCCACTTGGACGCCATTAGAATGGCGCCCCCTTAGCTGAGTAGCGGGAAAC CTGAGCCCACCGGGCCAGTGGACATTCCTGCGGCCAGTGGTGCTCAAG

>'000127a-094.scf came from CONTIG 80 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-094.scf ' (51>346)

CTCGCACACAGGGTTATTGTTACCATCTTTCTAAATTCCATATATATGCGTTAGTATACTGT ATTGGTGTTTTTCTTTCTGGCTTACTTCACTCTGTATAATAGGTTCCAGTTTCATCCATCTG ATTAGAACTGATTCAAATATATTCTTTTTAATGGCTGAGTAATACTCCATTGTGTATATGTA CCACAGCTTTCTTATCCATTCATCTGCTGATGGGCATCTAGGTTGCTTTCATGTCCTGGCTA TTATAAACAGTGCTGCGATGAACATTCTACCAAGAGGGGAGGNNGGGG

>'000127a-095.scf came from CONTIG 81 at offset 0;"E:\SEQUENCE\export\EST_db\000127a\000127a-095.scf'(51>350)

CGCACCCTCACCGAGCACTCCTACGCCGTGTCTGCCGTGTCTTCCGTGGCTGAGGCTTACA GAAGGCAGCCTGCCCGGGAACAGGACAGCAGCTCACCTGCGAAAACAGGGAAGGAGAAC

TCTGAAGCTGTTGCAGCAAAACCGAAAACATGCCGAAAGCCAAAGACACTCTCCGTACCC

CAGGAATCAGATTCCACTCCAGAAAATATACCACCCCCTCCAGCAAGCAACTGGGAGGTG

CGTCAAGAAGTAAGTCCGCAGCCAGCTGCAGCTCTTTCCCTTTCAAATCCCCACCACGAA

I >'000127a-096.scf came from CONTIG 82 at offset

0;"E:\SEQUENCE\export\EST_db\000127a\000127a-096.scf'(50>473)

CTGACATTAATTGTACACCCAACCCTTAAAAGATATGTTCTGAAGATGCCTTTGGTTTGAA ATAGGAAGGTTGAAGGAGACCCTAAGTATTTTAGGATTTTTTTTTTAATAAAGTTT^ GCCCCTTTAGCATGTTGGCCTGTTTGCATGTAAGGGTGGGCAGAGGGGCATTTACAACCTG ATCTCTCTTCTCCCTGGGCTTCTCCTNGTGCCAAGCTTGGTGGGTGGCNTAAAAGGGNACA

GACAAATCTCCTTTTCCATCGACCTGTACCCTCTGCTGGCCGCTCCTCCAAAGCTAAAGGT CCCTGTNNCTGTTGTTNACGCACTGCTCTTGGACCTTTCAATAGAGGAAACACACGTGACA CGATCAACTCAGACCGCATCAGTTTTAGTGAGCCTGGATCAGTCTTTCAGTCTGGGA >'000128a-001.scf came from CONTIG 1 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-001.scf'(46>520)

AATTGGCACGAGGGCACTCCAGCTCAGCACATGACCCTGAGACCGCCGTCCACTGTGGAT GACAACAGGCGGGAGAGATAGCTGACAAGATCTACAACCTGGATAATGGGTACACGAGC GGCAAGGAGCAGCAGGCCGCCTACAACACGCTGATGGAAGTCTCTGCCTCCATGCTGTTC CGCGTCCAGCACCACTACAACTCACACTATGAGAAGTTCGGCGATTTTGTCTGGAGGAGC

GAGGACGAGCTGGTTTTTAGAAGGCCCACCTGATCCCTCGGCGGCTGGAGAGGTGAGCAG CCACTGGTCCAGCCTCCTGCGAAGCGCCTATATNCAGAGCCGNGTGGACACCGTGCCCTA CCTCTTTGCCGCACGAGGNAGGTCGGNCTGCGTATGNNNGNGGNTACAGCATCTCAGGAC ACCAAGCACGTGCGAGAGAAAATAGTGTCATGGNCCGAACACTACGGGAGGCAGAN

>'000128a-002.scf came from CONTIG 2 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-002.scf'(49>547)

CGACCCCCTTGTGTTTCATGTCCGCGGCGCTCTGCTCTGGATTCGGAAACGGATACCATGT GCGCCGGTCAGCGCTCGGCGGGCGCCCTGGCGGCGGCAGCCCCGCGCACAGAGTACGCCT TCTCCGCGCGCCCTCTGGCCGGCGGGGAGCCCTTCAACCTGGCCTCCCTGCGGGGCAAGG

AGCTGCTCATTGAGAACGGAGCATAGCTCTGAGGCACAACGGAGCGGGACTACACCCAG AAGAATGACCTGCAGAGGGGTTTTCGACCCCGGGCCTGGACGAGCTCGGCTCGCCTGCAC CAGGTGGGCATGAGGAAACGCCAGACGAGAGATCTGATTGCTGAGTACGCCGACAGCGN GGGTCGAGCCAACTAGCCTTGAAGGCGAGGAATNGAAGAGGCTCGTCTCGCTTCTGGGAG TCGCCAGCAGGACAGCATGTTATACGACTAGTATACGCCCGGGGCGAAAAGTCTGATTGA ATCTGGGCCAAGGGCCGGCC

>'000128a-003.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-003.scf'(52>478)

GCACGAGGCTTTTTTTTTTTTTCCTCCπ^

TGACCCCGCTGGCTGTACTGTGAAGTCTCTATGTTTTCTGCCTTGACGAAGCACAAAAGCT TGAGATGCTATATTCGAAGGCGCAGTGTGCCTTCGAATGTAAAAGAAGAGAAAACAAATG CAGACGGGGACCCTTTTAAAGTGGAAACCGACCACCGAGGCTGGGGGGCTGCCGTGAAC AANAACGCCTTGCNTTTTCACCTTGCATCCTTGAGCGATGGGTGGACCATCCTGTCTGCAG

AGACCCCCCTGCGATGCCCGGGGCAAAGCCAGCCCTAAGCATAGATGATGATCTTTCACA CAAAGAGGAANTTGTAACTTATACTCCGAGCGCTGGATTTTAAGACATCCATGAGGGTTT CTG >'000128a-004.scf came from CONTIG 4 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-004.scf'(48>489)

CGGGTTTTGAGTATAGCCGTTCTGGAAATCCCACCCGGAATTGCTTGGAAAAAGCAGTGG CGGCGCTGGATGGGGCTAAGTACAGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTGAC CATTACCCATCTCTTAAAAGCAGGAGACCAGATTATTTGTATGGATGATGTGNTATGGAG GTACAAACAGATACTTCAGGCAGGAGGCAACTGAATTTGGATTAAAGNATTCTTTTGTTG

ATTGTTCCAAACCCAAATTGCTNTNTNCAGCTATTACACCAGAAACCNAAGCTGNTGGNA TTGAAACCCCCACANACCCTAGCTTGAAGATGATNGACATTGAAGCCTGCGCACATACGG NCCATANACATGNAGACATATTTNGGGNTGNGGATACACTTTATGTCAGCATATTCAGCG CCTTGCTCTGGAGCGATATTG

>'000128a-005.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-005.scf'(46>459)

TGGGCCCCCCTGGATTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTCCTGGTG CTGAAGGATCCCCTGGACGAGATGGTTCTCCTGGCGCCAAGGGTGACCGTGGTGAGACCG GCCCTGCTGGACCTCCTGGTGCTCCTGGCGCTCCCGGTGCCCCCGGCCCTGTCGGACCTGC

CGGCAAGAGCGGAGATCGTGGTGAGACCGGTCCTGCTGGTCCTGCTGATCCCATTGGCCC CGNTGGTGCCCGNGGCCGCGTTNTTCCCCAAGGCCCCGNGGAGACAAGGGAGAGACAGG CGAACAGGGCGACAGTAGCATTAAGGGTCACGNGGCTCTCTGGTCTCCAGGNTCCCCCGG CCCCTCCGCTTNCTGTGAGCAGGTCCTTTCGAGCTCTGTCTGCTGTCCCCGCGC

>'000128a-047.scf came from CONTIG 5 at offset 14;"E:\SEQUENCE\export\EST_db\000128a\000128a-047.scf'(50>548)

TTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTCCTGGTGCTGAAGGATCCCCT GGACGAGATGGTTCTCCTGGCGCCAAGGGTGACCGTGGTGAGACCGGCCCTGCTGGACCT CCTGGTGCTCCTGGCGCTCCCGGTGCCCCCGGCCCTGTCGGACCTGCCGACAAGAGCGGT

GATCGTGGTGAGACCGGTCCTGCTGGTCCTGCTGATCCCATTGGCCCCGTTGGTGCCCGTG GGCCCGCTGGTACCCTTNNTCCCGTGGTGACAAGGGTGAGACAGGCGAATCAGGCGACAG TAGCATAANGGGGTCACGTGCTCTCTGGTCTCCAGGGTCCCNCCGCCCCTCCGCTTNCTGT GAGCAGGTCCTTNCGAGCTCTGTCTGCTGTCCCGCCGTCCCTGCTTGCTGTTCTCCCGCAG ATGACTCATGGCTCCAGCCCATCGTCCCTGCCTGAGCGATGGATGTGTCGCTGTCCTCGCC

TCGACCCTGTCCAGN

>'000128a-079.scf came from CONTIG 5 at offset 43;"E:\SEQUENCE\export\EST_db\000128a\000128a-079.scf'(49>648) TGTGGAGCTCCTGGTGCTGAAGGATCCCCTGGACGAGATGGTTCTCCTGGCGCCAAGGGT

GACCGTGGTGAGACCGGCCCTGCTGGACCTCCTGGTGCTCCTGGCGCTCCCGGAGCCCAC GGCCCTGTCGGACCTGCCGACAAGAGCGGTGATCGTGGTGAGACCGGTCCTGCTGATCCT GCTGATCCCATTGGCCCCGTTGGTGCCCGTGGCCCCGCTGGACCCCAAGGCCCCCGAGGA GACAAGGGTGAGTNCTTCGAACAGGGCGACAGATGCATTAATGGTCACCGTGGCTTCTCT GATCTCAGGGTACCACCCGGCCCTCCNGGCTCTCCTGTGAGCAAGGTCCTANCGAGCCTCT

GTCTGCTGGGCCCGCGTCCCCTGCTTGCTGCTCTCCNGCAAATGACTCATGTCTCCAGCCC ATCGTCCCTGGCCTGAGTCCCTGTGTGCTGTCTGCTGTCTCCGCCTCTGACCCTGTCCCAGT CTCCACGGGCTCACTGACTCTCCCANCACTCAAAGTCGAGTGGCGTTACGGCGGTGCATG GNCGGACGACGCGGGCCCACTCACGNCCAAGAAAACGGCCCGGCCGAACCCCCCCC >'000128a-006.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-006.scf'(51>507)

GCACGAGGCAGAGTCCTGGTGACGATTGCCGCGTTCGCCCCCTCAGTCCACTCCGCCAGC CCTCCACCGCTGCGCCCCGCCAGCCCGCCCCTTTCCTGTGCCAGGCACTGACAGGCACCAT

GCCCCACCAATACCCAGCACTCACCCCGGAGCAGAAGAAGGAGCTCTGTGACATCGCTCA CCGGATTGTGGCTCCGGGCAGGGCATCCTGACCGCAGATGAGTCCACCGGGAGCATTGCC AAGCGACTGCAGACTNTTTACACCGAGAACACTNGAGAGAACCGGCGCTACTACCGCCAA CTGCTGCTGACTGCCGATGACCGCGAGAATCCCTGCATCGGGGCGTCATCCTCTTCACGAG ACGCTGTACCAGAAGCCGATGATGGGNCGNCCTTNCCCCCAGTTATAAAGCCCAGGCGNG

GGGNGGGCAATAAGGAGAAAAGGGGGGGGNCCCTG

>'000128a-007.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-007.scf'(47>316) TCGGTGGGATCTCTTTACGTCCTCTGGACTGGAGGCCGAGCCCCCGCCCGCGGCCGAGCCC

CGCGCCCGGCGTCTCCGCCCGGTGTGCTCTCCGCAGTGTTCCTGGGCTTGGGAAGACCTCG GGGAACATGGCGAGGCAGCGGTGGTTTAACGGGAAGGACGGTGACTGTTAGCCTGTGAA CGAAAGCGAGAGTGAGCCGCCTCACGCTCCGGACCAAGAGTGATCTTGAACTTGAGGCTG CTACTAGATTATTGCCCACACCTGCTNTC

>'000128a-008.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-008.scf'(45>464)

TAAAAAAAGGAAGCTTGGTCCACTTGCTTGAAGACCCACGTGGGGGTAAGTCCTTTTCTG CCCATTGGGCTTATGACACCCCAGCACTGCCCTTTCTGCTCCTTTCTCCATGCCTTCTTAGG GCCTCCCCTCCACTGGTCCCCAAATCTAAGTCTCCCCAAAAGACACAGGAAACAATGCAT

TGTCTGCCCAGCAACCAAAGGCAATGCTGAAACACCCAAGAGGCCCCCACACTCCCAGCC CACTTCCTTCACCCAGAACCTCNTNTTCTGGGGGACCTGGAGTGCTCAGACTGCCANAGA AGCTTTACCATCTGGCATCCCTGGGGCCCGGGCACATTCCCCTCTTGTTTTGAGGGAAGCA TGCCAGGGGGACACTGGCCCTTCATCACAGNTGGAGGAANGCAGAAGGGNNCAGANG

>'000128a-010.scf came from CONTIG 9 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-010.scf*(316>320)

TTGAA >'000128a-012.scf came from CONTIG 10 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-012.scf'(43>539)

TCTCAACTCCATGATTTGTGGAGAGAAGGAACGAATCTTTGATGGGAAAAACAGAGAAAA

ATCCCTCTTTTTTCCCCCCCATTCTTATAAA^ AGTCGAGTCCGACTCTGTGCGACCCCATAGACGGCAGCCCACCAGGCTCCCCTGTCCCCG

GGACTCTAGGCATTTAGAAATTNTTTTTATCTGTGAGGTATTATAAGTCATTAACTATTCCC TTTCGATAATAGATGTAAGCAACTATTAAAAATATTAGTTAGTCACAGATTTGACTGAAAA TCTCTTACAAGAAGAGGAACAGAAATAANGAGCAGNTNGAATGGNGCTGNNACATGGAA ACATCAAGAAAGGNGACACACTGTTTTTTTTTTCTATCTCTATGTTTAATTTAGNAAAACA ACTNTGATG

>'000128a-017.scf came from CONTIG 11 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-017.scf'(100>532)

AGGAAGGTCGGGGCTGGGGGGGGGAAGGCGCGGGGGTGGGGGGGGGAGGAGGGGAAGG GGAGGGGGGGGGGGGCGAGGAGGGGAGGGGGGGAAAAGGGGGAGGGGAAGGGAAAGA

AAGGAGGGGGGAGAAGAAAAGAAAAGAGAAAGGGGGGGAATTTGAGAAGGAGGGGAA AAAAAGGGGAAAAGGGAAAAAAGGGACAAAGGAAAAGGGGGGGGGGGCGAAAAAAAA AACGGGAAGGGGCCGAACGAAGGAGGAAAAAACAAAAGGGGAATTAAAGCAGAGAGGG AAAGGGGGGACTACGGGACAAAGTTGGGAATGAAGGAACAAAGGCCAAAAGACGCGCC CCAGGGGCCGGGAAAAAAACAAAAACGAGATACCGAACGGGAAAGGAAAAAAAGATAC

GATTAAAAACCCCCCCCCCAAATACGGGAA

>'000128a-018.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-018.scf'(60>253) AAATATTAAGAACGTAAGAAAAGCTCACTATATAGAAAATGCTATACCCGGAACAAAAC AATGGGGCAAATGCTGGTGGAGGAGACAAAAGGGAAAAGCAAAGGCAAAATGGCAGGG AGGAAGGGAGAGGAAAAGAAACCGGAAGGGCGGGAAAGGCAGGGAGAACACCGCGGGT GAAGGGCGGGATAGAGATG >'000128a-019.scf came from CONTIG 13 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-019.scf'(99>348)

AATAAGAAATAGGCTCCTTGTAAGTCTTTATGAAAACGGAAACTTAGAGGGTAAGAGGAC TGGTGGGGAATACAAGTTGGTTGGGATTAAGAGATGATGAGCAGGAGAAAGAAAAATTA TGACCATATATGGAATGGAGGAAGAGGAGGGAATATGGGAGAAAGAAAAGGGAAAGGG

ACGGACGGCGGCTTTGAGGGAAGAAACGCGGTCTTCCAAGAAATAGAATAAAAGAAAAA GAAGAGGAGGGGGG

>'000128a-020.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-020.scf'(l>365)

AGGGGGGTTAATAGACCCGCGCGGGGCCGGCGCTGATACACCACCTGGGGGAACCCTTCC GCGCAGAGAAAAGACCTGGACCCAGGCAAGAGGGACAGAGACATCCAGCCGAAGAAGG GCGCCTGAGAAAACATATATGGGAACGACAAAAGAGACACTATGAGGCAAAGGGCCTGG GGATCCATTGTAGGAGGGATCCAAAGCCAATGCCTCAGCGCGGAAGAACCTGGCCTTGGA ACCAAAGGCCACACACCGCGAAGGAGCCAACAAAAAGGGGAGGGGGCCTCTTGGAACGA

AAAGGCTGCCCGAAAAAAATAATTGAATTGGGGGGGAAAAATGGCAAAAAACCTAAGGG GGTTGGCCGC

>'000128a-021.scf came from CONTIG 15 at offset 0;Ε:\SEQUENCE\export\EST_db\000128a\000128a-021.scf'(3>262)

GCGTGGGCGTTTAACTCGGTCCCGTCTCGCGTTCCGGCCTTTGATATCTTTCATCTTCGTTG GGTAACCGATCTCGCGCAGACTGAAAATACCCTGGGGCACCCTATGGCCACAAGCTTGGT GACCCAAACGCTACCACTCGCCAGTTGCCGGACATGATATGTGCGCCTGTGAGATTAGAG AGATAAGGGGAAGTGAGAGAGAGAGAAGAAGAGGGGGGGGGGGAGGGGGGGGGGGGTT TTGGGGGGGGGGGGAGGGGG

>'000128a-022.scf came from CONTIG 16 at offset i

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-022.scf (411>415)

CAGAA

>'000128a-023.scf came from CONTIG 17 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-023.scf'(336>462)

GGGGCGCGCGGGCTCTGGTGGGCCGGGAGGAGGGGGTAGGGGGGCACGGGGGGGGGGA

GCTTTGGCAGGATAGAGGCCCCAAAAGGAGAGGGAACCCGCCGCCCCGGGGGGGGCAGG GCCTGGGCGG

>'000128a-024.scf came from CONTIG 18 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-024.scf'(29>467)

GGCTGTGTGGACTTACAGGACTCTGAGGGCGCTCCTCATGAATGAAAATTAAGCAACACG GAGGGAAGGGAAAGCGCACCACTTCATATAACTTAAACAGTTGTGAGCAACCTGGCTAGC

CTGGCTGGCGCTATGAGACGGGAGCTGGGCACGAAGAGCCACTGGTCGTAAGAAAAGGA AGTCGGGGAGTTTGAGGCGCAAAAAAAAAGCCCGCAGCCCCCGGACCGTCAAGCCAAAT GGGGCCTGGGGACCAGGGGACCAAGGGACGACCAGCGGGACAGGGCCAGAGGAACGTA AGAAGGGCAACGCAAAGGGCAAGGCCGCCCACCGCTAAACCACACCGCACGCCGCCCAA TAAAACATGGGGTAAAGCGCGCCTTTTGTCCCCGCCCCCCCCTCATTTTCTGGGGGTCGGT

ATTTGTAAATTAAAAAAATTTTT

>'000128a-025.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-025.scf'(l>247) CACGGGTGCCCTTTAATATGGTCCCCCGGGCTGCTGCTGATTTCTTTTTCTTTTGGTAGGCT

GATGCACTTTGTTTTGCCAGTCAATGGCAAGATAAAACTAAGTGAGAAAGAATGCAAGGG ATAAAAAAAATTTGCATAGGGCATGTGAAAATGTCTCCATTTTTGGTTGTTGGGGTTAAGA TGGGGTGGTGTGGGGTGAAGTAGGGGATGGGGTTGAGGGGAGGAGGCAGGTGGTGAAGG GGAGG >'000128a-026.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-026.scf'(l>587)

CAGGGGCGTCGTTTACTTTGATTCCCGGCTGCGGAATTCGCACGAGATTGATCTACCAGCT CCAATTAAAACTGCAGGCATAAGCCCAAAATGTGACTAATATAAAAGCCCTCAGGCATGT

AATTAAATTATCCCAGTGCCTTTTTTAGTTTTAATATCAAGATTGAATCTGTTATGTAGAGG CACCAAAATGAATGTCATGCTGGNAGTCTGTATGCATGACTCAAATATACCTAATACAAT GTCAGAGNTGTATAAGCCAGCAGAATTTATTTTATAGCAATTCAGTATCTGTTTACCTACA GGNTCGGGGTTGGGGAGTATATTATGAAGAATCAGATTAGAACTGACTACTAAGAGACTA TGGATCCACTATTAGCCACTCAATATAGACCACGCTAGACCCNAGAGAGCTATACAAAAC

AAAATCTATTCNCCCTACTTATTTAAGTCTCCTTTATACATACCAGGCCTACTGCTAGACG AAAGTGAGGGGCCTGGGAGGCACACTGACTCCCTTCCTGCCCAGCATAGGAATAAGAGTC AAAGAGAGATACTCACACCTTTCCCCTTCGGGCTAAAGCGCG >'000128a-027.scf came from CONTIG 21 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-027.scf'(40>80) CGCTGCATGGCACATGCCGCCACAATGCCACACTATACCAT

>'000128a-028.scf came from CONTIG 22 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-028.scf'(l>525)

CACGGGGGGCGTCTAAACTAGGGATCCCCCGGCTCAGAACTGCACGAGTAGAACAAACC ACACGTTAATACTGCTGTGTGATATGAAGCCATAGATCTTCTACTATGCTTGGATACGACC TACGCCCAGTGCAGAGTCGGGGGTGCGTGCTTACAGACCAGATGATGTATGATTTGCGCT GGAGCATGCGAGAAGATAAATAACTACCCTAGCGCGAAGAGGCTCTATAGCATAAGTATG CGAGAACATGCGGACCAGTTCTGAAGTAGAATAAGAGCATGCTGGAGCTGTTCTTGCAGT

GGACACAGTGAAAGACACATAGGCTGACAACAGATGTGCATGACAGATGAGAGACGACT CACCGAGGAAGACACAAAAAATAAGGAAAGGGCGCAGAAAGTGAGCACTCAGAGGTAA CTGGCGACATGGGACTTGGCAATCAGCGCAGGAGACGGGCCTACTCACGCTGGCTTTTGC ACACCTAATTGAGAAAGGAGCGAGGGCGACTGGGGGTGGGGGTGTGTG

>'000128a-029.scf came from CONTIG 23 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-029.scf'(l>363)

AGGGGCTCTAACAGTCCCGCTAGATGCCAGCATCTCTCAGAAGCGCAGGTCGCACTCGGT AGGAGCGCGCCAGGCAGGCGGGGAGCGAGGGACGAGAGACGACAGAAGGGCCCTAACC GAAACTGTGCCGCCCAACTGGCAGCTCGAGGAAACGTACGCCAGTGAGACCCAAGTTTCC

CTATCAGAGACGGCAGAACACTACGGTGGCGAGAGCCCAGCCGAGCGCCAAGCCTCGAG GCGGGAGGAGCAGTTGGCTTTGGGCTGCTGTAAGCAGTGACCACACGCGTTAAAGTCTCA GACCCCAAAAAAAAAAAAAAAACGGGCCGCCAGCTAGAGTTAACGCGGTAGGGAGGACG GTCCTAC

>'000128a-031.scf came from CONTIG 24 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-031.scf '(1>431)

AGGGGCTTAACTGTCCCGTAGCTGCTGGCCGGGTGAGACTTTTGCTACCCGATCAACCGGC GACGGGCGGTCGCTCCGGACTCGCAGCGGGGAGGGTCACTACTCTGCGACGAGGGAAGA GCGGCGTGTCCGGAGCAGAGGAAAAATTGACTAATGAACGATAGAGCTCTAGTTTTGCTG

GACCCCGAGAACGACACTCCGCCACCACGGATCCCAGGACTCTGACGAACCAAAAGCATG ATGAGAGACGAAGTAAAAGCTTTGTGGGGAGGAGGGGAACACCTATCGACACGACCCCG TGACAAGGGATGGGGCACCTAGATGAAGAAAAATACAGTGAGTTATGAGGAAAAAACTG AACTTGTAATTCCACTGAGGGGGTAAATAATCAGGATGGCCTCCGCGCTCTTGCGAAACC GCTTTCTTTAAAG

>'000128a-032.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-032.scf'(178>503)

GTCGCGCAGAACGCAGAACAGCCCCGAGATCACCCAGACTGCCGAACGAGCCAGACTTG GGGTGCCCCTCGAAAGCAGACAGAGCTGAACTAAAGGGCCCTTTTTGGACGGGAACCACG

CCTGATATTTCACAAAACAAGCGGCAATAGAGAGCTGTATCCCACCTACTTATAGCAAAC CAAGGAGAAGGCCCAAAATTTTCAAAACAAAGAGAAAGACTGGGATTTGCCCAAAGTAG GAGGAGCGAACCGGATCCCCTCAATCAATGCACAGATCAATTACTAAAGCTTCCCGGCAA AAACTGTGCCGCCTCAACATTAGAACGA >'000128a-034.scf came from CONTIG 26 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-034.scf'(l>120)

CAGGGGGCGTTAACAGGATCCGGCTGAGGAAAAGTCATGTACGCATGCTACCAGGAAAG AAATCAAGGGACGGCACTTGAGAAGCCTTTATGGGGGGTGAGGAGGGGGGGGGGGGGGG

GG

>'000128a-035.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-035.scf'(54>235) GCACGAGGCTGTTTCATTAGCTGCTTTATATGGAGAAGAGAGAAATTCTGTGTCTTTCCAG

ATCCCAACAAGGGGTGCATAGAGTCTGAAGACATTCTTTTCTATTTTCCTAATCCCCCTTCT GCTGTCTCTGGGAGTGCCTACTGGCACAGAGGCAAGGTATTTGCAGAGAACAGAAANGT

>'000128a-036.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-036.scf'(43>286)

CCCGCGTCTACTTTCAGAGCCCCCCGGGGCTGCGGCGAGGCCCGGGCGCGCGGACGAGAG GGCCCATGAGGCGCCAGGGAAGGTCACGGTCAAGTACGACCGCAAGTAGCTACGGAAGC GCCTCAACCTGGAAGAGTGGATCCTGGAGCAGCTCACTCGCCTCTACGACTGCCAGGAAG AGGAGATCCCAGAGCTGGAAATCGACGTGGATGAACTCCTGGACATGGAAAGCGATGAT ACCCGG

>'000128a-037.scf came from CONTIG 29 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-037.scf'(l>281)

CACGGGCGCTTAATAGGTCCCGGCTGAGGTTGGCTGTTATTGGATTGTGAAATGCTTACTA

CGAAAATCTGAAGCTAGCCAACGATGATTGAAATCACAAGTGGGACAGCAGGAGGAGTA

TCAGCTCTCTGAAACTCTCAGCAGCTCGCGAGCCGCATAACACTGCGACGATAACAGAGA

CGCTTGTTCAGTCCTNAGAATCACAAACCAGCAGATGAACTAAAGACGCAGGACAACTAT

TCATACCCATGTTGGAAACATGACTTCAAAAAATAAATAAT >'000128a-038.scf came from CONTIG 30 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-038.scf'(8>426)

GTTAATAGATCCGGCTGAGTGAAATGTGACACCATTCACTCAAAAAGGATTGACCCTAAC CAGAGGACCTACTGCAACGAGCATCACTGGCCCAGCTTGAGCAGGGACAGAGAGAGTCA GAGCTGCCCCTGTACGCAAAGGAAGCAGCTCAGGTAGCTCGCAATCAGTGAGAGAGTCGG ACAATGAAACAGATTNCGCACTTGTTGCCGCGGAGACGACAGGCACGCACNGCTGTGCAG

CAGCCCAGACCATACTCAACCTACAAAACGTCAAAGTGAAGGAATGTGAGAAGAAGGGC AGCCGTGAACACACGACGCTTGCTAACAGAACAAAACCCACTGCCAACAGCCGACGGCC ACCCTAAACCAGAGACTAAAGAAAAAAAGACTACACAACCATGGGGATTGAAAGGCGCG AGG

>'000128a-039.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-039.scf'(48>549)

GGAAATTGCCCCAGATGCGTCCTTCATTGATGACGAAGCATTTAAGCGGCTGCAGGGCAA AAGGAACCGAGGGAGGGAGGAGATCAACTGTGTGGAGATCAAAGGTGACGACCAGCTCA GTGGGGGCCCAGCAGTGGATGACCAAGTCATTGACAGAAGAAGAAACCATGAAATCATT

CAGCAAAAAGAAAGGTGAGCAGCCAACAGGCCAGCAGCGGCGGAAACACCAGATTACGT ACCTGATTCATCAGGCTAAGGAGGTTNTNCTGGAGCTGAAGAAACACTGGTCGGGAGAAC AAGCTCAGCCGCCGGCAGACCCAAAGCAAATANNCGATCTAGGGCTCTGGACTGACTGCT CTGGATCNCTGCAAGCCACTGGCTCGGGCCCAGCTCGNCTCTGGACCCAGCTGATCGAGC CAGATCTCTTTCCTGAGACCNAGCCTCGCTCTGGAGATGACTATTGAAGATTTTCTACAAA

GTAAAAATCACTCTTCTGGCTGGA

>'000128a-040.scf came from CONTIG 32 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-040.scf(47>605) TTTTTTTTTTTTGCAACAGTAACCCCCTGTCCAGAGTCTGACTGTAGCTGAACTGTTCAGAC

TGAGGAATGGAGCAGGCTGTGGGCGCACGCCTGATCCCTCCTGGGCGAGCGCCCCCACCC TCAGGGAACAGGCTCCAGCCAGACCAGCTCACTGCTTGCTGGCCACCACACACTAGCCAT ACAGAACATCATCATTATCTTCTGAGTACACACTGCCACCTGTGCCACCGCCACTGCCCTG ACGGGGACAGCTCATTCTNGTTACTGAGGGAATCTGAGCTGGCAAGCCTCGACTTGCTGA AGGGCTGAGCAACATTCATACTGCGGAGTCATTATACTGACAGACGGCGGCAAGCGCATA GCTCTCAAGGATCCGCGGATCTAGCCTGATCATCTTTTATTCATGCTGACGGTGTTGCGTC CGTCTGCCATTACTTGATGATCAGAGGCACTGAGGCGTGCAATTGGCAGCATCAAAACCT ATCTTTACAGACTATCATCTGCATGGCTGGCGTGCTGAAGAACGGCTCTTGAAGGAAAAG GAAAGGCGGGAGAGG

>'000128a-041.scf came from CONTIG 33 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-041.scf'(14>537)

TTCTATACTATGGATCCCCGGGCTGCGGTTTTTTTT^ TGCTTTTATTATGAATATAAAATATACATACAACATAATACACATTTACACATTTACAATT

TGCAGTTAGTTTCACTTTTTTGAGCACGTTTGGTTCTGCACGGCACAGTGGCCCATGTTCCT TCCACTTACACTCAAGACATTCTCTTCACCTTGATACATACTTGGGAAGAAATACCAGGCC GAGCGTCANATGGCCAGCTTCACTGTCTTCCCAGAATCACTTNTCTTCTGATTCCCCTTTGC TGCTACAGGCTTTCATGGCCCTAAACTCCAGCATAAAAAATGCAGAGAAAAGAGGCTGCA GAATCCCCTTCGNCTTTCAAATCACCCTGAAACATCCCACCTGACGAGGNGAACATCATA

GCATGCTGGATAACATAGCTAAAAACTACTACAGGAGCTTGAAGGACACATACAACTAAC TGTCACCATGATGATACAAGGATCGAATCGGGTAT

>'000128a-042.scf came from CONTIG 34 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-042.scf'(48>687)

TAATTCGGCACGAGGGTTGCTTTGGGAGCTCTCCAGCACCTTCAGGAAAGGTACAAGAAA TTNTTAACAAATCATTI AAAATGCAATTTAAAATTCTCAATAAAAGTGATTTTπ CATTTATTTATGGCTGAGCTGGGTCTTCTTCGCTGCGCACGGGCTTCGTCTAGTTGCTGTGC AAGGGCGTCTCATTGCAGAGACTTCTCTTGTTGCAGAGCACAGGCTCTAGACGCGGAGCT GCAGTACTTTNCGCACANCNNNTCAGNAGNTGTAGCTCCCAGACTGTAGAGGGCAGACTC

AGTAGATGGGGAGGGGCACAGCTTAGTGCTCTGAGGCATGTGAGAATCTCCAGATCAAGA ATCAACCTGTGTCTCCTGCATTGCAGGCAGATTCTTTACACTGAGCCTCAGGNAAGCCAAA GNGATATTAATATTAAATACTCTGATTGATATGAATTTTTTTTTCCTGTAATCATCAGAAA AAGGGCGGCAACAAAAACTACGCCAAGCACACTGCTCATCTCATTACTTAAAACANAACT ACGTCNAAGAAGAGAGAACTTCTATACAGATTACCAGACTTTAAAAATAGTGGGCTGGAA

TTGGTTTATGGGAATGGAAAAAATTTGTTTCCCGG

>'000128a-043.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-043.scf'(334>638) AGAAGACAAGGAAACAGAGAAGAACAAGGGCACCCAAACACACACACCCCGGGCCCTGC

GGTTCGGACGGATGGTGCCGCCCTGAAGAACTCCCAGAGGTCCGAAGGGACGGAAGGGG GAAAAGGGTTGGGTGGAAACCCCCCCCTTCCGGCGGCCATCTGGACCCTTTTACCCAGAG GGGGCTCGCCCTAAGAGGTTTATGTAGGCCGGGGGGCCGAATAACTGCAAAGAAATTAAG TGCAGAGTTTTAAAGTGAAAATTTTTTGAACCCTACCTCCTAATTTGTTTTTCTGGGGGGG GTTTAG

>'000128a-044.scf came from CONTIG 36 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-044.scf'(l>359)

CGGGGGGTTATAGTCCGCTAGTGGCGCGGGTGGTTGTGAGAGGGTGTAATGTAGACAGCT ATTAGAATACAAGGAATTAAAAAGGAAGGCAAAATGATATATGTGAAGATGTAATCAAT

AAAAAAGACACACACTAATCAAGTGTGGTAGACAAATATATTGTAATGCTATGCGATAGA

GAATATGATTTTGGCAGCTTTGCTACGACTCCAATATGNGGAAGTGGNCGAAATTTGTGG

GTTTGACGGCGTGTGGCGCGCTCTATAGTGGTGAAATTTGAGCAGGAGGAGGAGATCAGG

AAGTGGGCACGGCTTCTGTCGAGCGATGCAATCTCGATAGGTTGGGCTAGGGCGGAGGGT

>'000128a-045.scf came from CONTIG 37 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-045.scf'(50>308)

GCACGAGGGGCAGAGGTGCAACTTTCTTCGGGCGGCCCGAATCCGGGTTCATCCGACACC

AGCCGCCTCCACCATGCCGCCTAAGTTCGACCCCAACGAGATAAAAGGCGGAGCGTGCTT TAGATGTGGGCCGGGGCTTCGGGATGCGGCATCCCTCCCCGTATTNCGTCCGGGCCGCGG

CGCCCGCCGCTATGGGCTTTCCCACGTCGGGCCTCAAGGCCGCTGCCTCCTAAGGGCCCTG

CCTCTGGTGCTGNNNNNA >'000128a-046.scf came from CONTIG 38 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-046.scf'(54>610)

GCACGAGGGCTCCCCCCTCCCCCCGAGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCT CCGGGCTCCTGCTAAGCCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTA CCGGGACCTCATTAGCCATGACGAGATGTTCTCCGACATCTACAAGATCCGGGAGGTCGC

GGACGGGCTGTGTCTGGAGGTGGAGGNGAAGATGATCAGTAGGACAGATGATAACATCG ATGACTCGCT(^TTNATGGAAATGCCTCCGCTGAAGGCCCCGAGGGCGAAGGTACCGAAA GCACAGTAATCACTGGTGTCGATATTGTCATGAACCATCACTTGCAGGANACCAGCTTCAC AAAGAAAGCTACAAGAANGTACATCAAGATTACTGAAGNCAATCAAGGGAACTTGAGAA CAGAGACAGAAGAGAANACCTTTATGACAGGGNCTGCGAACAATCAGCCATCCTTGCTAT

TCAAACATCAGTCTTATGTGAAAACTGATNCAATGCATGGTGCTTGTGACTACGGAGAGG GGNACCCATATGATTT

>'000128a-048.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-048.scf(52>580)

GCACGAGGGTGCTTTGAGTTCCGTCTGCGGCCAAGGAGCTCGTCCCCCACCTACCCCCACC CTCTTCCTCTCTCCTCCCAATCCCAGGCGTTCCCGACACTCTAGGCGTCAGGAGGCACGCC GACCAGCGTTCCGGCTGGGGAAAGGGTGGCGAGCGGGACCGCCCGACGTTGGGGTTCTAG TGTGAGACGCAGGTGCGGTCGGTNTCAGGAATTAGGACATCGGCTGGGCCTGAAACTCGC TGGGCATGCAGNNNNTGTCCCTCGNCCGCGGAGACTGGCTGTCTCACGGAGCGAGGGACG

TGCATGTACCCCCGCCTCAGAAAGCGGCCNGCTGGCAGCCTCATGGAGGTGGNNTGTGAG CAGTGNGAATAACACGCCANAAAGCTAGCAGCTGGCGACAAAGTCAAATCCTCTGCGNN CCACCCACCCAGCATCAGCAACTACGCCAGGGACAGNGCCTGCCCATCTGNGTCTCGTCC TCCGACCCCCTCCCCCCCCCTCTCTGCTACTCCCGNGCCACGNATGTG

>'000128a-049.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-049.scf'(48>538)

TTTCTTGGAACTAAGAAGGACTTACCTGACATTGGCCTCATTCTGGCCTTCACTTGTTCATA AGAATCATGGAACCAGAGTTTGAGTTAAGAAACTTGGAAAAAGCAGCTGAAAACATCTCA GAGTCCACTTAACAATTTAAAAATTCCACTTAAGATGCTAAATAATCCATTGCTTATGTAG

CAACTCAACGATGTTCTCAGGNTCCCCAGTTCTTTCTGTCTTTCCCCTCTGNGATCCTTATT GTATGGGGCTTTGNNNNCACGGNNTTCTCAGNGAGTACATATAGGCTGNTGCTGCNTCAG ACATTTNCATCTCTCTCAAGACTGGNAGTAGGNAGCAAAACCTTNGTCTTTCAGTCTCTGT TTTTATTTGGAAGAANAATCTCTTCTCAAAGTCCTCACATTTNCTTNATCTCATACATAGG ATTTCCCTACAATCTGATCACAGGAGCTGAAACGACAGGANGGNAGTGATGCTGGTAGAC

CATG

>'000128a-050.scf came from CONTIG 41 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-050.scf'(8>563) GCGTTAACTAGGGTCCCCGGCGCGGGGTCTGCTTGCTTACAGGCTGGACGGACAGACCCA

GGACGCCCCTTGCTCCAGCCTCCGACCACCCTCCAACCTTTTTTCCAGTCGCAACCTTCGG AGTCAGCCACTCAGCTGTCCGCGATCACCGGGACCAGCCACCATTTTTTAATCTCTTATTA TTACCGACCAATCATGAGCTGCCAGATTCGTCAGAATTATTTCTACGAGGTGGTAGGCGN NCGTCACCGCCTGGTTAACATGCATCTGCNNNNCTCTACACCTACCTCTCTCTGGGCTTCT ATTTCGACGCGACGATGTGGCCTGGAGGGTGGGGGTCACTTTTTCGCGAATGGNCCAGAG

AAGCGCGAGGCCGGAACGCTCTTGAAACTGCAAACCAGCGGGCGGCCGGCCCTCTCTGGG AGGNCAAAACCATCTAGAGANGGGGGTAAACCAGACCTAGGAGCCGCTCTCGANAGAAA ACTGATANCTNTGGACGCAGGCTGGCTTGCCCGGAACCCAATTGGACTCTGAAACATCTA ATGGAAGAANCAAA

>'000128a-051.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-051.scf ' (1>671)

CCACCGTGTGGCGCCGCTCTATACTATGGATCCCCGGGCTGCAGGCTTCAGTGGCAGCCA GTGCAGGGGGTCAGGGATCATGGGGGAGAGCGCTCTGGAGTCGGGGCCTGCGCCCGGAG CGCCGGCAGGGGGTCCGGTGCACGCCGTCACGGTGGCCACCCTGCTGGAGAAGCTGGCCA

CCATGCTGGAGACGCTGCGCGAGCGGCAGGGGGGCCTGACTCAGATGCAGGGCGGGCTG GCGGGCTCCGTGCGCCGCATCCAGAGCAACCTGGGCGCGCTGAGACGCAGCCACGATACC ACAGTTTTCACGCTGGCGCAGCTGCTGGCCAAGGCGGAGCGCGTGGGCTCGCACGCGGAT GCCGACCAGAACGCGCCGTGCGCCGCGCGCCCAGAGCAGAGCTGGAGACACCACGACTG TGGTGCGCGCGGTAGTCCACGTCTGCCTTAAGAGAAGCTGAATCCCACCAGCCTTCANAA GCGCGGACCCTAGCCCGGGAACTGGCCAACTGCCGACCGACGAAAAGTCAACAGAGAGC CGGGAGCAGCCGAGCGAGGACCGGTGAGAAGACAACTGCAGCCCTCAGCCAAGGCGCGC CACACAGCGTAGCCCCGCTGGCGCGAGNTGGCCGAGACACCTGGGCACGACAACCCCAA CGGGACGGACGGGCGAG

>'000128a-052.scf came from CONTIG 43 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-052.scf'(44>569)

AATTGGCACGAGCTCAGGGCACCAACGACTCACTGATGAGGCAGATGAGGGAGCTAGAG GACCGCTTTGCTAGTGAGGCCAGCGGCTACCAGGACAACATTGCCCGCCTGGAGGAGGAG

ATCCGACACCTCAAGGATGAGATGGCCCGCCACCTGCGCGAGTACCAGGACCTGCTCAAT GTGAAGATGGCGCTGGCACGTGCAGATTGCCACCTACCGGAAGCTGCTGGAGGGCGAGG AGAGCCGGATCAACCTNNNNNATCAGACCTTCTCTGCCCTCAACTTCGAGAAACAAGCCN CGACAGAGGGGGTCTGAAGTCATACCAGAAGACGNGATGATCAAGACATGAGACCGGNA GGNNGAGTCGGAGTGAGGCAACACAGAGATGAGTGCTCTAAGCAGAGTTTTTGCTGCAAN

ACGGCTCACTTGTCTACTGCTCTAAGCANNCTCTCTTCAGCACACCCACCATGTTCCTCAA CTTGACTGTTCGGACCCTTTGTCCCAGGAAAGACACTCAGCAGTACCC

>O00128a-053.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-053.scf'(43>620)

ATTTCGCACGAGGGGAAGGTTTTCCTGGCAGGTTGATTTCGAGTCAGCATGTCGGCTTCAA TGAAGGAATGCCTTCAGCTTCAGCTGCTGGAGATGGAAATGCTGTTTTCTATGTTTCCTAA CCAAGGAGAAGTAAAACTTGAAGATGTCAATGCCCTGACGAACATAAAGAGATACTTGG ACGGCATAAGGGAGGCCTTGCCACCAAAAATCGAATTTGTGATCACCCTGCAGATCGAGG AGCCCAAGGTGAAAATTTTCTTGCAAGTAACCATGCCTCACAGCTACCCCTATGTAGCACT

ACAGATGTGTGCACGGTCTGCAGAACTTGACAGACAGCAGCAGCTGCTTCTCAACAAAGG CCTCACTTCCTACATCGGGACTGTTGATCCCAGGGAGCTCTGTGTGTGCGCGGCATNCAGA GTTACAGACAACAGGCCTCCTACTTCTGACAGAAGCTGTGGACGAACATGAACAGCAAGC CATCAGAACACTCTNCGATGTGACTACGCACATATTTCAGAGACCTCGAAAGACTGAGNC GGAAGTNGACGACGAATTGAGAAGAAGCGGATACG

>'000128a-054.scf came from CONTIG 45 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-054.scf'(39>53)

GGTCTGCAGTTGCTC

>'000128a-055.scf came from CONTIG 46 at offset

0;Ε:\SEQUENCE\export\EST db\000128a\000128a~055.scf'(10>290)

CGTTAACTGGGTCCCCGGGCTCAGTTCCGCCCCCGCCCCACGCGCCCAAAAGGCTGGAGC

CTCATCGCTCCATGTGTGGTATTTGGGGCTCTTTGGGGGAGATGACTGGCTTTTTGTTTGTG GGTGATGGGTTTTAATATTGCTCACAGGGGTCCGGGAGCATTTCGTTTTGAAAATGTTAAT

GGGTACACCAATTGCTGGTTTGGATTTCACCGGTTGGAGAGAAGATGACCAGCTGTGTGG

TATGTCTGCCGATCCGAGAGAAAGAAATTATNCTCCTT

>'000128a-057.scf came from CONTIG 47 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-057.scf'(53>548)

GCACGAGGCCAGTACACAGGTGTCGTGAAAACCACCGTTAAACCTAAGCCAAAAGGGAA AGGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCAGGGAAGTCTACCA CGACTGGCCATGTGATCTACAAATGTGGCGGGATCGACAAGAGAACAATTGAAAAGTTCG AGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAAC TTAAAGCTGANNTCTTGCGTGGTATCACCATTGATATCTCGCTGTGGAAATTTGAGACCAG

CGAGTACTATGNTACCATCATTGATGCCCCCAGACACAGAGACTTCATCANAAACATGAT TACAGGCACATCCCCAGCTGACTGTGCTGTCCTGGATCGTGTGCTGGTGGTGGTGGATTTG AAGCCCGGATCTNCAGAAACGGCAGACCCGNGAGCATGCCCTTTTGGCTTTACACCTGGT GNNGAANCACTANTG

>'000128a-056.scf came from CONTIG 47 at offset 20;"E:\SEQUENCE\export\EST_db\000128a\000128a-056.scf'(77>499)

TGTTGTGGAAACCACCGCTTAACCTAAGCCAAAATGGGAAAGGAGAAGACCCACATTAAC ATCGGTGTCATTGGGCACGTAGATTCAGGGAAATCTACCACGACTGGCCATCTGATCTAC AAATGTGGCGGGGATCGACAAGAGAACAATGAAAAGGTCGAGAAGGGAGCTGCCGAGAT GGGAAAGGCTCTTTAAATGCTGGTCTGACAACTTAAGTTTTTGACGGGGTCACATGATTCT CCTGGGAATTGAACAGAGTATATGTACTATGAGCCAAGAACAAACTATCAAACTGTTCGG CCTCCAGTGATGGCTGCGATGGTGTGGTTGGATTGAGCGATTTCAACGCAACCGACTGCCT TGTTACTGGGGAAATATGGGGTACAAGATCCTACCCTANCAAAAACAATGTGAAACCTTT

AA

>'000128a-058.scf came from CONTIG 48 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-058.scf'(9>565) GCGTTAAACTAGGGATCCCCCGGCTGAGTATTCGGCACGAGGGATCCCACAAGAGGCTGG

ACCCTAGACATACTCTTGTTGAATAACGCACACATGGTGTATAACTAGCACGCACGTAAA ACATCCGTTTTACGTAGCCACAGGAGGGGGAAACCATATAGATGAAAACACTGAGTCTGA GACGTGGACATCCCAGAAGTGTATAAACTAAACTTACCTGAGTATAGGAAGAACCTCTGA TATCCGTGAGCAAGACAAGGAAAAAGAAGAATTCTGAATATATGGGAAAGCCAGCGCTA TAGGGAGAGCAACAAGGACCATGAGAGCCAGATATATGATGGGGAATAGAGAGGACACA

CGAGGATAACATACACATAGAGAAAGCTATCAACGGGGAAAAATAAGCGATGAGACACT CATGGTGGACTGAACGGCCGGCATAGGGAGGCAACGATAGTATACGAGGGAAACGAACA ATATGACGCAATAAACGAGTAGAAAATGGGAGCTACACAGTGTTTAGGAGGAGCTATGG ACAAACGGGTTTTAAATTCCGG

>'000128a-059.scf came from CONTIG 49 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-059.scf'(40>518)

GTCTGCTATTCGGCACGAGGGTTTACCAGCTTAGAGGTCTTGGACCAATTGAAGAAGACA CTATTCTTGTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTT TTACTTGCCACATGGCTTGAGTATAGATAAAGATGGAAAGTATTGGGTCACAGACGTGGC

GCTTCATGAGGTGGTCAAACTAGATGCAAAGAGTAAAGAAGGCCCTCTGCTAACCCTGAG AAGGAGCATGCAACCAGGCAGTTTTCTAGAAACACTTCTGTGCAGCCCACCGATGTGGCT GNGGGACCAGACACCGGAACCATCTATGTGTCAGATGACTACTGCAACAGTCGCCTTGTG CAGAGTTCACCAAGTGAAAAATTCATCACACAGTGGGGAGAAGCGTCTTAGAAAACAAN CCTATACAGACCCAGTCAGAGTTCTCACAACTTGCCCTGTNGCCTCCCTGGCCACTGGG

>'000128a-060.scf came from CONTIG 50 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-060.scf'(45>469)

TTCCAATGAATATTCAGGACTGATTTCCTTTAGGATTGACTGGTTGGATCTCCTTGCAGTCT AGGAGGTATTACTTACATATTGTAAAATTTACCCCTGTAAAGTATACAATTCAGTGGGTCT

TTATATACTCACAGTTATATTTAΛTAACACTAATCTCAGAAATTTCATCACCCCCAAAAGA AGTCACATACACATTAGCAGTCACTTCCCATTTTCATTCCTNCCATCTCCAAGCAGCCACT ATACTAGTNNNNACTATGATTTGTCTACTTTGGACATTTAACTATATGAATTCTACAATAT GGGCTTTTGTGACCATT πSfCTTTACTTTACAAATATTGATATTGTGCAGGGCAGGGGCATA CTCATTCTCCTCTGTTCTTAGTAGATGGNGAGAGAGAAAGAAAAAAAAAAAATGTAAA

>'000128a-063.scf came from CONTIG 51 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-063.scf'(49>634)

CGCTGACTATTCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATTTGGTGCTTG GGCCGGTATAGTAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGG

AACTCTGCTCGGAGACGACCAAATCTACAACGTAGTTGTAACCGCACACGCATTTGTAAT AATCTTCTTCATAGTAATACCAATCATAATTGGAGGATTCGGTAACTGACTTGTTCCCCTA ATATTGGTGCTNNNNTATAGCATTGCCCGAATAAATATATAAGCTCTGACTCTCCCTCCTC ATTCTACTACTCTGCATCTCTATAGTGAGCTGGGCAGGACAGCTGACCCGGTACCTCCTTA CAGCAACTAACCTGCAGAGCTAGAAGACTAACATTTCTCTTAACTAAAGAGATCTCATTTA

GAGCACACTTATACACATATAAAAAGACCCGCAGGACATACAACCTTGTGTGAACGATAT ACGCGACATATACTTTCCTGTTTAAGGCTACAAGTTTAAACGAACAAAACCTTTGACGGG AGAGGACTTTTTAACTTTTGTTTGCCCGAGTTTTATTTCG >'000128a-064.scf came from CONTIG 52 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-064.scf'(54>595)

GCACGAGGGGGATCTACACTCGAGTCAAGAACTACGTTGACTGGATAAGGAAGACAATG CAGGAGTATAGTGCCCCCAGTGTAGACTAACCATACAGGTCCCACCAGCCTCTCTAAGGG CTGTGACCCCTCTGGACTTTCTCTTCCTCACAATAGTTCCATTATTTCACCATGACTGAGAG AGGACACGGGAGTGAGATTGAGCTAGTGCCAGGACTTGGATGTCGGGACACTGGGTTGGA GGTAGGGTGTNTNTCCTGTGGCTGTGTTGGTCTTTCAGTATAGATGGACTAACTACATGGG GTCCTCTCCCCCGAGTCCATCCTGTGGACTTGAGTGTGCAAGGGAAACCCTCTCTTTCTCT ATTCATGGGTGGNNNAGGGTCCTCTTCTGGATGACCCACTCCTGTTACAGATCTGACTCTG AAATTTGCTGTGGGGCATTCTCTTGATTTTNTTGGGTTNCCCTTTACCGTTGAAGTTGACCA

CACGTTCTGCTACTACTGTAATAAGCATGTTATAACCCAAAAAANAAAAAACTGGA

>'000128a-065.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-065.scf'(50>578) GCACGAGGTGAAACCTTAAATCCCACAACATTTATTATAAAGGTGCTGTAAAGGGAAACG

CTGGGCTTCATGACGGGCTTATCGGTAGGATTTCTGGTAGCGGGCACGGGCACCAGGACC TCCAAACTTCTTGGATTCGCAGCGACGGGGATCGGCTACCAGCAGGGTCCGGTCATACTG GATGAGGATGTCTTTGATCTCCTTCTTGGAAGCCTCATCCACATATTTGTGGTAATAGGCC ACCAAGGCTNATTAGATGGACTGGCGGATGGCGTAAATCTGGGCGACGAGACCACCACCC TTCACTCGGACGCGGATGTCCACACCAGCAAATCGCTCCTTGCCCNAGAGCAGAACAGGT

NCCAGTAGCTTGTATGCAGCGTGCGCGGTTCGATCATTCTCAGGGTCGTGCGTTCACCTGA TGAGGNCGNTACCTCGTTTGCAGTGCGCCAGGCTGTGGCCGNCTTCTTACGNCCGAGACTT GCACGACTGCAGAGGCCCTTTGGACGCATGGCTCAGGCGCAGAACG >'000128a-066.scf came from CONTIG 54 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-066.scf'(50>515)

CCGGGGACGAGGGCCTGACCCACTNACAAACGTGTGCTAGACTACCCGAGGGACCCTTGA AAGCCAAAGCTCGGTCCCCGGTAGCGTCGAAGGCTACGAATCTTGTCCGCACCAACGCCG ACCTGAGGGGGGAGGGGCTGCAGCCAGGAAGACAGAGCGGAAAGAACAAAGGAGGGCG AGGAAAACAGGCGAAGCACAAAGAAAAAAACAATAAACCAGCGCAGTCGGAGGAGGCA

CACGTGTGGATGGGATGAGCTCTTCTATGAGAAGGACAGCGCCGGTGCAGCCAGACCTGA ATGCGAGGAGGAGGAAGAGACAGAAGTGGGAGAGGAGCAGGAGTAGGCGGCAGATTGG ACCTAGCACAGCTACAGAGAATGATGGCTGGGGGGAGAAGAGGCTGGATAGAGCGCGGG TAGATATGACACAAAAAGATGACGAGAACGCGCTGAGAACACGGGAGCAGAGA

>'000128a-067.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-067.scf'(9>545)

CCGTTAAACTAGGGATCCCCGGGCTGCAGGCAGAGACGGGCGCCGTCCCATCTCGGCCTC TGGGTAACTTCTGCTTGACTGACCGACCGTGACCCTGACATAGCGTCATATTCATGGCAGC CAAGGGAGGCACTGTCAAAGCCGCTTCAGGCTTCAACGCTGCCGAAGATGCCCAGACCCT

GAGGAAGGCCATGAAAGGGCTTGGCACAGATGAAGATGCCATCATCAACGTCCTGACCTA TCGCAGCACGGCCCAGCGCCAGGAAATCCGGACAGCCTACAGTNTTTCCATCGGCAGGGA CCTGATGGACGACTTGAAGTCAGAACTGAGTGCAAACTTCGAGCAGATGATCCTGGAGAT GATGACACCCCACGAGCTGTACGATGTGCAGGAGCTGCGTAAGGNCATGAAGGNAGCTG GCACAGATGAAGGCTGCTGATTGAGATCCTGGCTCCNGACACCGAGAAGAACGGCGCATA

ACAGACCTACACTGCATATGCGNAGCTGAAAAGAATCGTCGACCGCATCATGTCACG

>'000128a-068.scf came from CONTIG 56 at offset 0;Ε:\SEQUENCE\export\EST_db\000128a\000128a-068.scf'(51>578) CCGGGGCTATATTTATTGGCGCCTTCTCTCAACTGATCCTGTCACAGCTAAAGAAGTAGTC

TTGTCTGAAAAGCCACTGATTTCTGAGGAGACAGATCTTATTGAGCCAACTCTACTGGATG AGCTAATCTGCCACATTGGTTCTTTGGCCTCAGTGTACCATAAGCCGCCCAATGCTTTTGT GGAAGGAAGTCATGGAATCCATCGCAAACACTTGCCAATACATCATGGGAGCACTGATGC AGGAGACAGCCTTNTNGGCACCACCACTGCCACCAACCTGAAGCAGCCTCAGGTTATTCC CTCCAGGTGACCTTTGNGGGATCTTTAAACCTGACCNNTGTCCCAGGCATGTGCACAGTAT

CTTCATGCAATGGAGCAGGGATCTCTGGAGANGCTAAAGGCGNGGGAAGCCTCTCCACAT CAGGCGCACCTGTCCTCCTATCTGCGGCAGAAGGCGAGAACGTGACTTCCGGAAGCAGCA CGGGAAGGGTCAGTGTGCGCTGAAAGTAAACGGAATAAAATATA >'000128a-069.scf came from CONTIG 57 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-069.scf'(49>593)

TCAGGACAGAAATGTACAAGCTCATGGTCCGTATTCATAAATAGGAGATTTCGGGAAGAT GAGACTGGATTATAAACAGGATCAGTCAGAAGCTGAAGATCTTAAGGATATGCAGTGGAA GGCAAACATCTCTTCATTCCACAACAGAAAACTATGACGATCAGAAACTTTAAGTGAAAA AAAAAAAACAACGTTGTAAGAGGAACACATCCTTCAGATAACCAAACAATGTAAAATACT GCAGGGTTTTGACCGTTNTCTGGAGTGTAAGAAGGTGGACTCAATTTCAGTGTCACTCTAA TTCGCATTGTGGATCAGAATCTTGGAGCCAAAAAAAAGGAAATCCAATCATAGCACANAG CTTGGTGGNTTATTGAATAACATTTANATAATCATAATGGAAANTGCTGTTATGGNNTTCA TCTTTTTTAGAGAATGCTATTACGGTACAGANTGNAGTGNCATATTATCACCTGATGCGNA

NNNAGGCATACAGGNAGATGCAGGNCGGCGCTGGNAAGNAGGNNGNCTTTAAGNGGNA GCGN

>'000128a-070.scf came from CONTIG 58 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-070.scf'(50>628)

CGTGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTCCGTGACATCAAGGAGAAG CTCTGCTACGTGGCCCTGGACTTCGAGCAGGAGATGGCCACCGCGGCCTCCAGCTCCTCCC TGGAGAAGAGCTACGAGCTTCCTGACGGGCAGGTCATCACCATCGGCAATGAGCGGTTCC GCTGCCCTGAGGCTCTCTTCCAGCCTTCCTTCCTGGGCATGGAATCCTGCGGCATTCACGA AACTACCTTCANTTTTTCATGAAGTGTGACGTCGACATCCGCAAGGACCTCTACGCCAACA

CGGAGCTGTCCGGCGGGACCACCATGTACCCCGGCATCGCGGACAGGATGCAGAAAGAG ATCACTGCCCTGGCACCCAGCACATGAAGATCAAGATCATCGCGCCCCCTGAGCGCAGTA CTNCGTpTGGATGGNCGCTCCATCCTGGCTCGCTGCCACCTTCACAGAGNGGATCACAGC AGAGACGAGAGCCGCCCTCCTCGGCACGCAAGCTCTAGCGACGTAGCGCGTACCCTTTCT GCAAACTACTGCCAAACGAAGAAATGAGTCTTTGTTT

>'000128a-071.scf came from CONTIG 59 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-071.scf'(55>577)

GCACGAGGCAGGAATGGGGCCCTTACCAAGGAAAAGTCGGTGAAGCATATGGACTTGTG CCTGACCGTGGTGGACCGGGCACCTGGCTCCCTCATAAAGCTGCAGGGCTGCCGGGAGAA

CGACAGCAGGCAGAAATGGGAGCAGATCGAGGGCAATTCCAAGCTGCGGCATGTGGGCA GCAACCTGTGCCTGGACAGCCGCGCAGCCAAGACGGGCGGCCTGAGCGTGGAGGTGTGC GGCCCGGCGCTTNNTTAGCAGTGGAAGTTCTCGCTCAACCTGCAGCCGTAGGGGAGCCTC CCGCGTCTGCCCGCGCCCGGCCACCCAGCGACGAGCACGTCATCAAGTCTGTTTCTTAATA CTTNCGAGAAACTATATACCTCAGTATTCATCATGTCTGCAGGTCGGAGACTAGCGCGGN

GAGGGCGCACCAGAGCGGAGGAGAGGAGCTNTGCGCCCTCTCGCCTGCGCTGGCGNCCA CACCCTGGAGCACGGNCCGAGNNNGACGGAAGAAGGGCCTGCCAGG

>'000128a-072.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-072.scf'(36>612)

GTGCTGCATGAATTCGGCTCGAGGCTGCCCGGTGCTTGCCTGCTGCCTGCCTGCCTGCCAC TGTGGGTTCCCAGCACCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGC CTTGGCAGCCCCTCAACAGGAAGCCTTGCCTGATGAGACAGAAGTGGAGGAAGAAACCG AGGCCGAGGTGGCCGAGGTACCCGTGGGAGCCAACCCCGACCAGGTGGAAGCAGGAGAA TTCGATGATGGTGCCGAGGAAACCTTCTAGGAGGTGGAGGCCGAGAACCCCTGCCAGAAC

CACCACTGCAAACACGGCAAGGAGAGAGAACTGGACGAGAACAACACCCGCTGTGTGAG AGCCAGCACCCCACCAGCTGCCCTGCCCGCATCGGCGAGTTGAGAAAGAGTGCAGCAACG ACAAACAGACCTTCGACTCTTGCTGCCCACTTCTTGCACCAGNGGACACTGGAGGCACCA GAAGGGCACAACTGCACTGACTACACGGGCCCTGCAAACATGCCCCCTGCTGGACTCGAG CTGACGATTCCCTGCGCAGCGGACTGGCTAGTACGACT

>'000128a-073.scf came from CONTIG 61 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-073.scf'(55>610)

GCACGAGGCTΓCAAGGCCCTCATTGCCGCTCAGTACAGCGGGGCTCAGGTCCGCGTGCTC TCCGCACCACCCCACTTCCATTTTGGCCAAACCAACCGCACCCCCGAATTTCTCCGTATAT

TTCCTGCTGGCAAGGTTCCAGCCTTTGAGGGTGACGATGGATTCTGTGTGTTCGAGAGCAA TGCCATTGCCTACTATGTGAGCAACGAGCAGTTGCGGAGAAGCACTCCCGAGGCAGCAGC ACAGGTNNNTCAGAGGGTGAGCTATGCTGATAGCGACATAGTGCCACCGGCCAGCGGGG GGGGTGTTGCCTACCTTTAGCATCATGCACCACAACAAAGCAGCCACAGAAGATGCAGAG CAGGAGGTGAGGCGAANTCTGNNGCTGCTGGATGCTCACTTGAAGACGAGACTTNTCTGG

GTGGCGAACGCGTGNACGCTGCTGAATCACAGATGTCTGCACCTGTGTTGGTTTACAACA GNTCTGGAGCCTCTTTCGCCAGNCCTTCCTATACCCACGCTGGTCTTACTGCATATCANCC CCATCGGNCTGTTG >'000128a-074.scf came from CONTIG 62 at offset

0;"E:\SEQUENCE\export\EST__db\000128a\000128a-074.scf'(16>50)

AATGACCCCGGCTGATAATCGTTGAGGGGAGCTGA >'000128a-075.scf came from CONTIG 63 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-075.scf'(56>567)

GCACGAGGGGATTTTGCAGACATGATTCATATTTCCTTCTTAAAGTGTATTTCTTTCTGCTC GCAGTTAAACAGAGAAGGAGGGTCTGGCGTGGCCTCTCTGAGATTGTTAATGATGTAAAT TGAGTCCCTGGTTTTTTTACTTCCGTCTCGTGTCACATGACCGGCGTGCGCATGGAGTAGA AGGATGATGCTGAGAAGTCAAGGAACTGAGCACGCGGACGAACAGAGGCCGCGTCAGGC

GCCTTTCCACCAACCCACCCTCTCCCCTCAGTTTGGTTGTTAGTCTCACCCAGTCTCCTTGA GAAGATGGAGGGAGGCTGACACAACAGCGCGACACTACCCTGTGCCCCGCCCGACCATCA CGAGCCTACGTCCTCAAGAGCGGTGCCGCGCTGTGCGTGGAGAGTCAAACAGTATATGTG TATGAAACATGTACACATCAAGTTATGATATAAGATCTCAACTTCTAATTTAATTTTAAAA CTGATGTTGTCTAGGGGGGTTTGTCTT

>'000128a-076.scf came from CONTIG 64 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-076.scf'(50>486)

CTCGTGTGGACTTTATCTTGAGGGCAGAGAAGAAAGTAATTTAAGTGTGGAAGATAGAAT TGATTATGTTGGAATTCTGACACCGTAGCTCTATGGTACATCAAGCTCCCTTCATATGAAC

CTTCAAGTTGAGAGCTTTGTAAGATGCTGATGTGTGTTCACGTGTCCGGTCACATAAGTTA GTTCACGTGTCTGGCGTACTTCTCAAGGTAGTGTACTGTAAGATTAAAAGATGTTGTATTT TTTGTGTTTGTNNTAAGGTATTATTTGGTGAAAAGGATTGGGAATCCTACTACACTACAAT ACTATACAGTTGATTGTTAGATGGGTACCTAGGCTAACTNNTGTGGACTTATGAACAAATT GGATTTATGAACATGCTCTTAAATGGAACTCATTCATATGAAGGNGACTTACTGTTATAGT

AGATGGGGAGG

>'000128a-077.scf came from CONTIG 65 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-077.scf'(47>555) TGTTGAGTGGTTGTGAGATTTAAAAAGCAAAACAGACCACTGCTGGCTGGTTGGTGCCGA

GGTGAATCACCCAAAAGCTCCCATGCCACAGAGCGAAGCCGAGACCACGAAACCTGGGTT CGAGGCCCAGTGGGAAGGGGTGCATGGCCTCACTCCTCACTGCTGCTCACTTCCTCCAGG GCAGCATCTCCCCTGNGTTTGCACCCATGGGACTCATCTTTTGGGAGGGTTTTTGTGGTTG TNTTGTTGTACCTTTTTTTAAGGAGCAGAGAGGCCAGTGATCACCCCCGAGCCGGGCTGGG TAGCAGGTGACCTGACATGCGNNGATGTGCCCTCAAGAGCCTGGNGCCTTCACCGCTTTG

TGCTTGGGCTGNGTGTGCCTCGCTCCCTCTGGGGCGGNGGCCGCTGCAGACCTGCCCNAG GGTCCAGNNCGGGAGCCACCACTGATCATACCAGGCTGNCAGCCACGGACGCTCGCCTGG TCTGCTCACTTCCCTGGCTGGANNAGT >'000128a-078.scf came from CONTIG 66 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-078.scf'(49>560)

TTATTTCGGCACGAGGATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGAT TACAGGCACATCCCAGGCTGACTGTGCTGTCCTGATCGTTGCTGCTGGTGTTGGTGAATTT GAAGCCGGTATCTCCAAGAACGGGCAGACCCGTGAGCATGCCCTTTTGGCTTACACCCTG NGTGTGAAACAACTAATTGTTGGCGTTAACAAAATGGATTCCACTGAGCCACCCTATAGC

CAGAAGAGATACGNTTNAATGGTTAGGGAAGTCAGCACCTATATTAAGAAAATTGGCTAC AAACCCGACACAGTAGCATTTGTGCCAATTTCTGGCTGGAATGATNGACACATGCTAGAA CCAGTGCTATATGCCATGTTCAGGGATGGAAGTCACCCGTAGGGACGCATGCCAGGGAAC CACCTGCNTGAGCTCTGATGCATCTGCACCACTCGCCACTGACAACCTGCGTGCTCTCAGA GCTATAATGGGGATGTACGCCTGGGNCGGG

>'000128a-080.scf came from CONTIG 67 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-080.scf'(46>302)

TGTTATTCGGCACGAGGTAAGTGTAATCGGCAGAAACAACAGCAACATCTTTGACCTGAA CCGGAATTTCCCGGACCAGTTCGTTCAGATCACAGAGCCCACCCAACCAGAAACTATGGC

TGAGATGAGCTGGATGAAGACCTATCCATTTGTGCTGGCAGCAAACCTGGATGGAGGGAC TTTGGAGGGTAACTACCCTTGTGAGATGATGAACAAGGCAGTGCCACATATAGGAAATGA CCAGATGATGCTGTTCT >'000128a-081.scf came from CONTIG 68 at offset 0;Ε:\SEQUENCE\export\EST_db\000128a\000128a-081.scf'(51>540)

GGAGATGAACCGATAGATTTCAAAATCAACACCGATGAGATTATGACCTCACTCAAATCA GTCAATGGACAAATAGAAAGCCTCATTAGTCCTGATGGTTCCCGTAAAAACCCTGCACGG AACTGCAGGGACCTGAAATTCTGCCATCCTGAACTCCAGAGTGGAGAATATTGNGTTGAT

CCTAACCAAGGTTGCAAATTGGATGCTATTAAAGTCTACTGTAACATGGAAACTGNGGAA ACGTGCATAAGNNTNAGTCCTTTGACTATCCCACAGAAGAACTGGTGGACAGATTCTGGT GCTGAGAAGAACATGTTTGGTTTGGAGAAATCATGAGGTGGNTTTCAGTTNAGCTATGGG CATCTGAACTTCCGAAGACGTCTCGATGTCAGCTGGCATCCTNCGACTTTCTNCAGCCGGC TCTCAAACATCAATATCACTGCAGAATACATGCTACTGGATCATGCAGGGNAATGTAAGA

AGCTGAAGT

>'000128a-092.scf came from CONTIG 68 at offset 441;"E:\SEQUENCE\export\EST_db\000128a\000128a-092.scf'(63>428) GCTTATAAAGCCATAAACATAGGATACAAGAAGCTGAAGTTGCGGCGGGTAGGTAAGAA

AAAATGAAAGGAGAAGAACAGGACGGACACGGGCAGGAGGAAAGGACCAGGGGGAAGG GCGGGAGAGGGGGACAGAGGAAGGAGGGCGGAGGGGGGGGGGCCTGGAGGAGAGGAGG AGGGAGAGAGGGAGAGAAAAAGAGAGACGAAGAGAAAAACAGAGGAAGGCAGAGAGG AGACAGAGAGGGACGCGAAGATAGGAGAAGCAAAGGCTAAGTGGCTAGAAGAATGGAA GCAAACAAAGAGACACACGACAAGAAAACCACACCGCACGCTACTAAAAAGAATGGAAA

AAAAGAAGACAAATTGT

>'000128a-082.scf came from CONTIG 69 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-082.scf'(53>345) TCGGACCCGTGTCGGAACCTGACCGGACAAGAAGACGGAGCATCGGTGAGATGTGTACAC

GGCGTCACTGGCATGGGTGCCGTGGCATGTGTCACCATATGAGCACCACGCCTGGATGGC ACCGCTGGGCACCGCGGCTTGGCACACCACAAGGGCCCTCGCCGCTGAGATGGACGANAG GAGGTGGAGTAGCAGAGACGTATACAGCAGGGCGGAACAAGCAGGGACAGTATGATAGG GAGTACATCACTGTGGTGACATTGCATCATGGGATACTCATCATGATGCTGCCA

>'000128a-083.scf came from CONTIG 70 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-083.scf'(51>541)

CGGGCGGCCGCCTGGCCCGGGCAGTGACGCGGGCGCTGGCGCTGGCCCTGGTGCTGGCCC TGCTGGTCGGACTGTTCCTGAGCGGCCTGACCGGCGCGATCCCGACCCCGAGGGGCCAAC GGGGACGGGGGATGCCGGTTCCGCCCGCCTACCGCTGTCGCTCGCTGATCCTGGACCCCG

AGACGGGCCAGCTGCGCCTGGAGGATGGGCGCCACCCTGACGCCGGAGCCTGAGGCCAA CCTTACGAACGTTCCACGCGAGAGCGGGAGGGCCTTTGTGGAGCTGCACACGAACGGGCG CTTGAATGACAGACTGCAGGCCTACGCCGCAGGCGAGAAGGAGGCTGCTGAGTGCGGAG AGCTGATCTACATGTACTGGATGAACACGATGGAGAATTACTGCGGACCCTTCGAGTATG AAGGGGTATACTGTGAGATGCTCAAGAACTTGCTAGAGGGCAACCTGTAGTGGATGCAGA

AAGATATGGAGCT

>'000128a-084.scf came from CONTIG 71 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-084.scf'(47>645) CTGGTCCCCCAGGTCCTCCCAGCGGCGGCTACGACTTGAGCTTCCTGCCCCAGCCACCTCA

AGAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATGATGCCAATGTGGTCCGTGA CCGTGACCTCGAGGTGGACACCACCCTCAAGAGCCTGTGCCAGCAGATCGAGAACATCCG GAGCCCTGAAGGCAGCCGCAAGAACCCCGCCCGCACCTGCCGTGACCTCAAGATGTGCCA CTCTGACTGNTNTAGCGGAGAATACTGGATTGACCCCAACCAAGGCTGCAACCTGGATGC CATTAAGGTCTTCTGCAACATGGAAACCGGAGAGACCTGTGTATACCCCACTCAGCCCAG

CGTGACCCAGAAGAACTGGTATATCAGCAAGAACCCCAGGAATAGAGCACGTCTGGTACG CGAGAGCATGACCGGCGATTNCATTCGAGTATGGCGGCAGGGTNCGATCTGNCGATGGGN CATCCACTGACTTTCTGCGCCTGAGTNCACGAGGCCNCCANAACATCACTACATGCAGAA CAGNGGNCTAACTGACCACAATGGCACTCAGAAGCCTGTNCTCAGGCTCANGGATAGA

>'000128a-085.scf came from CONTIG 72 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-085.scf'(304>310)

CAAGCAG >'000128a-087.scf came from CONTIG 73 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-087.scf'(293>298)

AAACAC >'000128a-088.scf came from CONTIG 74 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-088.scf'(302>308) CAANGNG

>'000128a-090.scf came from CONTIG 75 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-090.scf'(56>598)

GCACGAGGTCTCCACGTACGGTCAGTTCTACGGTGGTGACAGCTACATCATTCTGTACAAC TACCGCCACGGCGGCCGTCAGGGACAGATCATCTACAACTGGCAGGGCGCCCAGTCCACC CAGGATGAGGACGCTGCCTCGGCCATCCTGACCGCTCAGCTGGACGAGGGAGGCTGGGAG GGGACTCCCGAGCAGAGCCGAGAGGGCCAAGGCAAGGAGCCCGGTCACCTCATGAGCCT GAGTTCTCGGAAACCCATGATCATGTACAGGGGCGGCACCTGCCGCGAGGGAGGGCAGA

CGGCGCCGCGCCAGCACCGGCCTGGTCCAGGGCCGGGCCAGCAGCTCTGGAGCCACCCGA GCCGTGGAGGTGATGGCCAAGGCTGCGCGCTGATTCCAACGATGCCTTTGACCTGAGACC CCTCGGCGCCTACTGTGGTGGGTGCGGAGCAGCGAGCAGAAAGATGTGCCTGGACTGTCA GTGGCTCGGCCAACCGGCGGTGCAGAGGCAGAGCCAAGCTTTGGAGCCTGTGGGAGGCCC TCCG

>'000128a-091.scf came from CONTIG 76 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-091.scf'(80>368)

CATTACATATTGTGACTGCTACTGTTATAATGATCCACGATCACTACGAGCACGAATGTTA CGACGCTGTTACACGATGAAAGTGGGTGGGCAGTGGCATGGATAATGGCGTCACACGAAG

TAATAATAATAGCAGAAACTGGCATAAAAGAAATCAATGGCACACACACAACGGCGGAA GGACAACTGCCAAGACAGAACCGCAAATGTAGCTACATTGGCTGCTGTAGTGTGGAAGGA GGAGGGAGCGAGGAAAGGGAGAGGGCGAGGCGTGCATGGACGAGTGGGG >'000128a-093.scf came from CONTIG 77 at offset

0;"E:\SEQUENCE\export\EST_db\000128a\000128a-093.scf'(52>500)

TTTTCGTTTAGAGTTGTTTATGCTTTATATGCAACTCTCTTATGATTGCACAAATCCTAACT AAAATTCTAGATAGATAAAGCTTCGTGGGGCTAGGTAAGAAATTATGCCAAGCTGGAGAA CAGCCAGGCCCGGGAGAAAGGAACGACCAGCCGTTAGGCCGGAAGGAGACAGAGGACG AGGCCGAAGGGGGACAAGCTAGGAAGACCAGAAGAAAGACAGACAGGGACAAAAAAAA

GAAAGCCAACAAAAAAACACATGAAAAAAGGCAGGTGACAAAGAACGACGCGATTATTT GAGAATCAAAGGCTACTATTGTTTTTAACACTAAAAGTAAAAAACGACGTAGCGGCGATA AGAAAACACCCGGCAAGCTTCTAAAAAAAGAGTGGGAAGAAAAAAGCAAAGTGCAAGA AACGGAAATCAAAAGCTAAATGAAAGGCCACTCC

>'000128a-094.scf came from CONTIG 78 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-094.scf'(l>358)

CTCAGGGGCGGCGTCTAAACTAGGTCCCGGCGCAGCCTCTGGCTGGTTCCCTACACGACCT TCCCCTAGCATCTCCAGACCATCCATTGAGCGTCGTACATGACGACACTAAGGACACCTTG AAGCAACAGGAAAGAGAACAGAGGGGGAAAGAAGAGAGGGAACCAATAGAAGTGGGGA

AAGGAGGAGGAAGGACCAAGGGAACGGCAGGACAAAGGACGAAGTTCTAGAAAGGAAA ACGGAAAAAGAGAAGAAAAGGAGACCAAGAAAAAAGAAGAAAGGCAATAAACAAGTAA AAGAACCACGATGGGGAGGAAGGGGAGAAACGCACACATAGCGGCAGGCGGGACCGGG GAAA

>'000128a-095.scf came from CONTIG 79 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-095.scf'(53>524)

CGGTCTGGGGCTGGTGTTCCAGCGCCACATACCTTAGCACCAGATGGACAGCTCCACAGC CCAGAGTCTCCTCTGTGGCCTGAGCTACACCTCTGCCGGCTCCCTCAGCCGCCACCTCTTG ATCGGCCACAAGGTGAGAGACCAGGAGGAGGAAGAGGCAGAGGCGGCAGAGCCAGAGG

AGGGGCTGGGGGAGGAGGTGCCCATGGGGACCAAGGAGAACGGACTGGAAGAAAGTGCC GAGGTCTCCAGTGTGAGGCGACTCCGAGACGAAGAGATCTCTGAGCCTGGCCCAGGATGA GGATGGAGCACGAGATGCTCCTAAACGACCACAGACCTGTCAGGACCGGGACAGCCACA CACCGAGACCCGCAGTGTGACCAGAGGCCCTGCAAGGCATGGGGCGGGTGGACGCGGGN CGACGCNGCGCTGCTGTGGGGACAAGGGAAANAACAGCCCACCAGGGNGAGTGGCG

>'000128a-096.scf came from CONTIG 80 at offset 0;"E:\SEQUENCE\export\EST_db\000128a\000128a-096.scf'(42>393)

GGTCTGCATGCGGTTTTTTTTGTGGTTTTTCTGGCGTCAGACGTTATATGTTAGTGGTGTGG GACTTTACTAGTTCTAGACTGATATACGATCCTGTATGGTGTGCGGTGTGCTTTAAAATGA ACACACAAAAGACATAATGGAGAAGAGGAAAAGAGGAGGAAAGGAGAGAAGAACGAAA AAGAGGGAGCGGAGTGGAGAGGAAGGGAGGGGGAGGAAGAAAGAAAAAGGGGAGGGA AGAGAGAAGGGGAGGTCTGGGGAGGAGAAAGGGAGAAGGAGGAAGGGAGAGAGGAGA

AGAGAAGAGTGAGATAAAAAGGACAGACAAGAGAACAGAAGAGAACAGAAGGAGAGA

>'000203a-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-001.scf'(45>465) GCACGAGGCTGTTTTATATTCGCCCATTCCAGTCCATTTTAATTCTCTGATTCCTAATATGT

TGATGTTCACTCTTGCCATCTCCTGTTTGACCACTTTCAATTTGCCTTGATTCATGGACCTA ACATTCCAGGTTCCTGTGCAATATTGCTCTTTTTATCATCAAACTTTACTTCTATCACTAAT TACATCCATAACTGGGTGGTGTTTTTTGCTTTGTTTTCATTCTCTTCTTCTTT^ TTTCCACTGATCTTCATTAACATATGGGGCACCTACCGACCTGGGGGGGTGATCTTTTCAT GTCTTTCTTTTTGCTTTTTATTCTGTTATGGGGTTTCAAGCAAGATATGAAGAGT^

CCTTTTCCGGGACACGTTTGTCAGATCACACAGACTGCCGCTGGGGTTG

>'000203a-002.scf came from CONTIG 2 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-002.scf'(48>297) GCACGAGGGATTCTTATACTTTCTGAGGGAGTTTAATGACCACTAGAGCTTGTCCTCATAT

TTTTTTCAGCTTAATACTGTATGTCTCGTAAGATGGGCCTTATTGCCTGTATTCTTTGATAT GTGATTAAGCCTATAGCTTTCAGTGACCAAACATTTTACAGAGTAAAAAATGTTAGGAAG CAGAAAAAGAAAATCTGATTTATTCTATGTCTCATTTATCCAGCCCTGCACTTAGATAGAA GTGTGC

>'000203a-003.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-003.scf'(40>551)

TTTTGACAGAGAACATTTTTCTCACATACACTTTCAGAGTCAAAGCTGTGGATGGGGGAGA TCCCCCCAGATCTGCAACAGCCACGGTCTCTCTCTTTGTGATGGATGAGAATGACAATGCT CCCACTGTCACCCTTCCCAGAAATATTTCCTACACTTTACTGCCACCTTCGAGTAACGTCA

GGACAGTAGTAGCTACGGGGTTGGCAACAGACAGTGATGATGGCATCAATGCAGACCTTA ACTACAGCNATGGGGGAGGGAATTCCTTCAAGCTGTTTGAGATTGATTCACCAGTGGGNG GGTTTTCTTAAAGGAAACTCACCCAAAGCATTATGGCTTGCACAGGNTGGTGTGCCAGNG ATGACAGGGGCAGCTTCCCATCTACACGATCTGTGCTGTGTTGTCATGAAAGGTTCTAAGC ACTGGATGACTCCCAAAGCAAAACTGCCNCCCCATCACCAGAATATACGGGACCAGCTAT

AATTACACAAAATAATGTTTGGGGGGGG

>'000203a-004.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-004.scf'(43>365) GCACGAGGGCCCTTTGACGTTCCGGCCGCGCGCCCCGCGCCTCGTCGCTATGCCTCGCAAA

ATTGAGGAAATCAAGGACTTTCTGCTCACAGCCCGCCGCAAGGACGCCAAGTCCGTCAAG ATCAAGAAAAATAAGGATAATGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACC TTGGTCATCACAGACAAAGAGAAGGCAGAGAAGCTGAAGCAGTCCCTGCCCCCCGGTTNG NNNCGTGAAGGAGCTGAAATGAACCACGCATGCTGCTTTGAACTGTATTAAATTTTTTAA ATTCTCAAAAAAAAAAAAAAAA

>'000203a-005.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-005.scf'(45>563)

GCACGAGGCCAAGAATACAGTCACCTGCAGCCGGGGGACCACCTGACTGACATCACCTTA AAGGTGGCAGGTAGGATCCATGCCAAAAGAGCTTCTGGAGGAAAGCTCATCTTCTATGAC

CTTCGAGGAGAGGGGGTCAAGNTGCAAGTCATGGCCAATTCCACGAATTACAAATCTGAA GAAGAATTTATTCGTATTAACAACAAACTGCGCCGNNGAGACATAATTGGAGTCCCAGGC ANTCCCTGGAAAACCAANAAGGNCGAGCNTAGCGTCATCCCCTATGAAATCACACTGCTG TCTCCTTGCCTGCACATGTTACCTCATCTTCACTTTCGCCTCAAAGACAAGGAACACCGTA TCGTCAGAGATACTTGGACTTGATTCTGATGACTTGTGAGCAGAAGTTTATCTCCGCTCTN

ATAATCACGTTTTATNAAGTTCTTGNTGAATGGNNATTCTAAAATGTAACTCCATGAGAAC

ATCATCCAGGGNAGCTGTGCTAGCTTTACACTACAA >'000203a-006.scf came from CONTIG 6 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-006.scf'(47>562)

GCACGAGGGTTTAATTAGTGTACAAGGAGGCTTCAAGAGGGCTTCTGTGGTGACCCCGTG GTAAAGCATCTGCCTACCAGTGCAGGAGACTCCAGTTCAGTCTGGTCTGGGAAGATGCCA CACACCCGGGGGAAACTGAGCCCATGTACCACAACTGCTGAGCCTGTGTTCTAGAATCCG GGGAGCTGGCACGAGAAGTCACAGCAATGAGAAGCCCACACACTACTANAGAGTAGCCA

CACTCACCACACAAGGCTTNCCTTGTGCTCAGTTGTTAGGAATCTGCCTGCATGGCGGAGA CCTGGGTCGATTCCTGGTCGGAAGATCCCTGGAGAAGGAAAGCTACCTGCCGGAGCCACA CGGAAGACCCACCTGACAGTCTGTGAAGAACTGAGAGCAGGGATAAACTAGGATCCTTGA TTGTCAACTCTATCAAACAAACTCTTCTGTTTTGTTTGCTTCACACTTCTGCGTGCAAGCTT TCCGCCCCTTTTNAAATAAATAATTTATTATATT

>'000203a-007.scf came from CONTIG 7 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-007.scf'(32>465)

GCTGCAGGAATTCGGCACGAGGCTAGTTTCTTGTTTTC^ GCCTTTTCTTCCACTTTATTTCATATTCCCACCACAATAATGACTCCTTTAATTTAAACTAA

AAACCATANAGGGTTCCCTGAAATTGTGGCAGCAAAGGAATGAAAGTGTCAAATACCGA GGGACAGGTGGGGTGGGGAATCACCGAATCGTCTCACTGGGCTCTTGAAGTTGCTGGCGG CTGAAGCTGCAGCTGGTAGGGCATTGATGGTATCTGAAACCGAAAGCCTGGGCCAACCTG GTGGCGGCCCCTTGGCCGGTACTGGGGTGCACATGAAAACATTGAAGGACCCGCGCCGCA GAAGCGCCTCCGGGGGGGGGCCTGTTGATTGGGGGTACACCCCTCCCCTGGGAAAAAATT

TCCATGGCT

>'000203a-008.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-008.scf'(39>747) CAAAATGTCTTGAAATGATATTACCATAATTTTAAGTAGGAAAGTTACCTGAACACTTCTG

CTTCCACTTAACTGACTGGCCCGCAATATTGTAGGAACAGCATGTCCTTTGTACTGTGGTA TTCAGAACAGCCACAGCACTCACTTTTTCCAAATGATTCTAGTAATTGCCTAGAAATATCT TTTTCTTACCTGTTATTTATTAATTTTTCCCCATATTTTTATATGGAAAAAAAAAT^ GAAGATACTTAGTATGCAGTTGATAAGAGGAATCTGTTCTAATTATGTTTGGTGGATTATT TTTATACTGTATGTGCCAAAGCTTTACTACTGTGGAAAGACAACTGTTTAATAAAGAATTA

CTTCCCAAAAAAAAAAAAAAAAAAAAAAAATAACCGGAGGGGGGCCCGGTCCCCATCGT CCTATGGGAGCGTTACCATCCACGGGCGGCGCTTACAGCNCGGACGGGAACCCGCCGTCC CCACCTACGCCTGCACCCACCCCCTTCCCGTGGGTAAAGGAAAACCCCACCACGCCTCCA CGTGCGCACCGAGGCGAGGAAAGAAGGGTAATTTGTAATCGTAATTTTTATATATTTTTAC ATGCCAAGCCATCCTTAAAAAAAAAAGAAGGGGGGGGTGTGTAAAAACTCTTAAAGCCC

CCGAGAAAAACCTAGGGCCCCCCCCCCCCTCTTTGGGGGCGAC

>'000203a-009.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-009.scf*(37>606) TAATTCGGCACGAGGCTCATTTTTCCATCTCTTATGAGGACACACATCACTGAATTTAGGT

TCTACCCTAAGTCCAGAATAATCTCATCTTGAGATCCTGAAACTTATCACATTTGCAAAAT TCAAGAGCCAGGGAAAGCTGAGCAGTGACTGCTAATGGAACAGGGTTTGCTTCGAGGGTG ATGAGAGTGTTCAGGGGTAGACAGGGATGCTGTTTGTACGACTCAGTGAATATACTAAAA CCC^AGGGATTGCATGCTTTAAAGAAGAAGCTTAATGTTTGTGAAATTAGTCTCAATATAG CTGTTATTTTTAAAAGAGCCTGGCTCGGGGAGCCATCAATCATACTGCTATTTTTATATCG

ATGTGCCAGCAGAAGTATTCTTAAATCTTTATGACACTGTTTTACTTTTGGCTGTCTCCCAC CTGGTTTAAATACATTGAACAGAACCCAGNGAAAGCCTATGGTACAGGGAGAGCCCCGCT TTGCCATGAGGGATAGAATTGGTGATGCCAGAGATTCCAAGAATTTGTGAAAAACCAGAC TCCGGGGCCGGGTAACCTTCTCCG

>'000203a-010.scf came from CONTIG 10 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-010.scf'(44>427) GCACGAGGAGAGAACTAGTCTCGAGTTTTTTTTTTTTTTT^ TACAATGCTGTGTTGGTTTCTGTCATACCAACGTGAATCAATCATAATTATATTATATATCC TGATGGCACATGTTAAGAATGCATTTTCTCGTTTGAACATTACTGAGTTGGGAGATATGCA GGTTATGGATTAGTCTCTCTTGTGACTACTGACTTAACTAAAATTCAGAAGATACAGCCAT TTACCTACAGTCCTCCAGTTAAAACATGGCAGACCTGAGCCTANAACCCAGTTTGCTCATT TTCACTCCAGTATCACCCAACTATACCTAAAATGTTCCCTCTGCAGATACTATTCAAAGCA CTTTATTTATTTCTAT

>'000203a-011.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-011.scf '(31>278)

CTGCAGAATTGACACGAGCACCCTCTCAAGACCGAGCTGCTGCGGCCACACTCCTACAGT CTGTGCAAGCCCCCGAGTTCACCCCCAAGTCTGGAGGGAAGAACCATGTCTGTGACCAGC

AACTGCAAAGAGCCAATGCCTGTGTGGTTGACAGCCGGCGTGGAGATCTCATAGCTACTC TTGCCACTGCCCGACAGCTCCCTGGCTCAAAAATTACCCTCATCTACTTGATAAGGATGAT GTACACC >'000203a-012.scf came from CONTIG 12 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-012.scf'(l>719)

TGATGCCTTCTAATTATGGTTCCCCCGGGCTGCTGGTGAGACCTGTGTATACCCCACTTTG CCCTGTGTGGTTCCAGAAGAACTGGTATATCAGTAAGAACCCCAAGGAAAAGATGGCTCG TCTGGTACGGAGAGAGCATGACCGTCGGATTTCAGTTCGAGTATGGCGGCCAGGGGTCCG ATCCTGCCGATGTGGCCATCCAGCTGACTTTCCTGCGCCTGATGTTCACCGAGGGTCTTCC

ATAACATCACCCTACCACTGCAAGAACAAGAGTGGCCTACATGGGACCAACTGACTGGCA ACCCTCAAGATGCCCTGCTCCTCCAGGGCTCCAACGAAGTACGAAATCCGGGCCGAGGAC AACAGCCGCTCCACTACAGCGACACCTAAAATGGCTGCACGATCACACCGGACCCTGGGC AAGAAGAGACGAATACAAACACCAAACTCCGCTGCCCACATGATGGCCCCTTGAAGTGGC GCCCATACAGAATTCGTTCGAGTGGCCGCCTGTTCTGAACTCCTTCCCCACCGCTCCTCAC

CAACCCTGCCCGACTCGAAAACAACACCAACGAACCCAAAACAAAAGGAAAATCACAGC TGAAAATTTTCTGCTTTCTTAATATTTATTTACACAACTACAACAAAGACACTCAAAAAAA AACAGGACGCCCCCCCTAGGCATAATATCGGTTACGGAGGACCGCCCCCTCCTCCC >'000203a-013.scf came from CONTIG 13 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-013.scf'(284>351)

ATGAAGCGTTATATTTTGTTAAATTCCGTTATATTTTGTTAATCACCTCATTTTTTACCCAT

AAGCGC >'000203a-015.scf came from CONTIG 14 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-015.scf'(l>680)

CTGCGGCCCTCTACACTATGGATCCCCGGGCTGCAGGCGGAAGATGGCGGCCACGGCGGT GAACGGGGTGGCCGGCACCTCGAGCTCGGGGTCTGCGGCGGCCTCGGGCGCGATCCTGCA GGCCGCGGCCGGCATGTACGAGCAGCTCAAGGGCGAGTGGAACCGGAAAAGCCCTAATC TTATCAAGTGCGGNGGAAGAGCTGGGCCGTCTCAAGCTGGTTTTGTTGGAGCTCAACTTCC

TGCCAACNNCACAGGACCCAAATGACCAAGCAGCAGCTCATTCTGGCCCGTGACATACTG GAGATCCGGGCTCATTGGAGTATCCTACGCAAGGACATCCCCTCCTCGAGCGGGACATGG CCCAGCTCAAGTGCTACTACTTCGATTACAAGGAGCAGCTCCCAGAGTCAGCCTACATGC ACCACTCCTGGGCCTCACCTCCTCTTCTGCTGTCCCAAACCGNTGGCTGATTCCACCAGAC TGGACGGTGCCTGCCAAGACATCCAACCACGGTACACAAGCATCGGGNCCTCGAGCATAC

GAGGAGGCAGTACATAGTATTCTGGCAAGCACATCCCGCGAACTACCTTCTCATGATTCG CTGAACTCAGAAGAAGTTGTGANGAAGGCATGAAATCTTTACAAGCCCGACCCCCTCACA ACCAAAAAAAAAAACCAAA >'000203a-016.scf came from CONTIG 15 at offset

0; "E:\SEQUENCE\export\EST_db\000203a\000203a-016.scf ' (8>560)

GCTCTATACTATGGATCCCCGGGCTGCAGGTTCGCTTAGGCGCAGACGGGCAAACAGAGC CAGCATGCCGGTCGCCCGGAGCTGGGTTTGTCGCAAAACCTATGTGACCCCGCGGAGACC CTTCGAGAAGTCCCGCCTCGACCAAGAGCTGAAGCTGATCGGCGAGTATGGGCTCCGGGA CAAACGTGAGGTCTGGAGGGTCAAATTCACCCTGGCCAAGATCCGAAAGGCTGNCCGGGA

GCTGCTGACGCTGGATGAGAAAGACCCGCGCGTCTGTTCGAAGTAATGCCCTGTGCGGCG GCTCGTCCGTATCGGGTGCTGGATGAGGCAAGATGAAGCTGGATACATCCTGGGCTGAAG ATGAAGATTTTTTGAGAGACGCCTGCAGACCAGTCTTCAGCTGGGCTGCCCAGCCATCACC AGCCCGGGCTCTCCGCACGCACACAGGTCGCAGCAGGGAGACATCCGTCTCATGGCGCTG GACTCCAAACCATCACTCTCCTCCTCCCCTCGCGGGGCGNCCGGCCGGGAAGAANAAGCA AAGACAGGGGGT

>'000203a-017.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-017.scf ' (44>531)

GCACGAGGAGTGACCAGGGTTAGCTGGGATGCCCTCAGACTGCACTGGACCAGCCCCGAT GGGATCTATGAACGGTTTGTCATTAAGATCCGGGAGACTGACCAGCCCCAAGAAGTTCAC AGTCTCACGGTTCCTGGCAGCCAGCACTCCGTGGAGATNTCCAGCCTCAAGGCTGGTACCT CTTACACAATCACCCTGCGTGGCGAGGTCAGGGACCACAGCACTCAACCCCTTGCTGTGG AGGTCATCACAGCGGAGCTCCCCCAGCTGGGAGACTTATTCGNGACTGAGGCTGGCTGGG

ATGGCCTCANACTCAACTGGACCGCAGCTGATCAGGCCCTTGAGCACTTTGTCATTCAGGC GCAGGAGGCCACAGGGTGGNAGGCGCTCAAACTCCCGGGGCCCAGGACATGCGGCTGGG ACATCCGGGCCCTGAGCGCNCCCCTACAGAGCACATCCACGGTGATCGGGCTATAGACCA GGCTCTT

>'000203a-018.scf came from CONTIG 17 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-018.scf'(13>586)

AAATATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGGTACCATCTATTTTTTCAAACCT GGCAGGAATCCCCGGGGGGAAGCCCGCATACTCCTTCCACGTTACCGCAGATGGTCAGAT GCAGCCCGTCCCCTTCCCCCCAGATGCCCTCATCGGCCCTGGCATCCCCCGACACGCTCGC

CAGATCAACACCCTGAGCCATGGAGAGGTGGTGTGTGCGGTGACCATCAGCAACCCCACG CGACACGTGTACACGGGTGGGAAGGGCTGCGTCAAGGTCTGGGACATCAGCCACCCCGGC AACAAGAGCCCGTCTCTCAGCTCGATTGTCTGAACAGGGATAAACTACATCCGTTCTGCA AATTGCTCCCTGATGGCTGCACTCTCATAGTGAGAGGGGAAGCTAGTACCCTGTCCATCTG GGACCTGCGGCTCCCACCCGCGCATCAAGCAGACTGACGCCTCGGCCCCGCTGCTCGCCC

TGCCATCAGCCGGACTCAAGTCTGCTCTCGGCTGCAGCGAGGCACATGCTGGTGGGACTG CACACCAACGCGTGAGGCATNCAGGCACCGA

>'000203a-019.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-019.scf'(13>287)

ACAACCATCTCATGGACCCCATTCCAGGAAAGCTCTGAGTATATCATTTCATGTCATCCAG TTGGCATTGATGAAGAACCCTTACAGTTCCGAGTTCCTGGAACCTCTGCTAGTGCCACCTT GACGGGCCTCACCAGAAGGGCCACCTACAACATCATATGGNAAGCAGTAAAAAAACAAN CAGAGCAGAAAGTTCGCGAGGAGGGGGTTNCCG

>'000203a-020.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-020.scf'(2>215)

CTTCCGTTATACTAAGGATCCCGGCCGCGGAATTCGGCACGAGCCTCAGTTTTTTTTTTCA GCCTCAGGCCCACCCTGAGGGTTCTCCTCCAAGCTGGCATCGCCCCACTTTACAGATGACC

ACCCCAGGCTTGGACAGGGCCGCCCCTGGACAAGAAGCTGATCAAGGCCCTCTTTGACGT GCTGGCGCACCCCCAGAACTACTTCAAGTACA

>'000203a-021.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-021.scf'(29>265)

TGAATAAGCTGGCTTAAGACTCAACATTCAAAAAACTAACATCGTGGCATCTGGTCCCAT CACTTCATGGCAAATAGATAAGGAAAAAGTAGAACGGGGTCAGGCTTAATTTTTTTTGGC TCCAAAATCACTGCAGATGGGGGTTGCAGCCATGAAATTAGAGATGCTTGCTTCTTG

>'000203a-022.scf came from CONTIG 21 at offset 0;'Ε:\SEQUENCE\export\EST_db\000203a\000203a-022.scf'(36>646)

AATTCGCACGAGGTGGAAGCTTTTTTGTCGGGGGTTGTGACTGGGGGCCGGAGTGCCCCA CCCGATTGGTGGGTCCCCTTCCGCATTTAGGGTCCCTGAGCATGCTTTCTTGCCAGGGAGC TGGAAAGTTTTCTGACCCTTTTCCCCAGAAAGAGAGACAATAGATTGCCTTCATTTTGATG

TCTGTGGCCTCAAAATTGATCATTTCCTGTCTCCTCCCTCCCTCCCCGCCCTGGGGCCCCCC GCCCATTCATCCCCACCCCTCCAGAGCCACTTANGACCCACTTCTGACTAATTATGGATTC CAGATGCTTGGGATAAAAGAAAAAGGACCAAGAACCCCTCCCCCTCTCTGACCTGGCCAA AGCCCTCCCCCAATCCCCAGGTCTCTGGAGGGCTCTGCTTAAGCCCGCCTCACCGANAGN AGGNATGTAGCTGTAGAAACAACCATGCAAACTGGGTGGCCTGCAGTTTACACCACCCAA TCTTCCCTCCTGGCTCCTTACATGATGAGGACAACTGGCTGAGAAGGGCGCAAGCGTCTG GCTCACTGCTATTCTGAAATAGAACTGGCTCTTGCTGGCGTGGCCTGGGTAGGGCCGGCA GAGGGG

>'000203a-023.scf came from CONTIG 22 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-023.scf'(l>640)

GTGCGTTAAATAGGATCCCGGCTGAGAATGCCGAGGAAAAGGCCAGGTTAAAAGGGCCC GGCCCGGCCGGGTGAAGAAGCAGGAGGCCAAGAAGGTGGTCAACCCCCTGCTCGAGAAG AGGCCCAAGAATTTTGGCATTGGACAGGACATCCAACCCAAGAGGGACCTCACCCGCTTT

GTCAAATGGCCCCGCTACATCCGGCTGCAGCGGCAAAGGGCTATTCTTTATAAGCGCCTG GAAGTGCCTCCTGCAATTAACCAGTTCACGCAGGCCCTGGACCGACCAACAGCTACTCAA CTGCTTAAGCTGGCCCCAAGAACAGACCACAGACAAACAAGAGAAAAAGCAGAGCTGCT GGCCGAACTGAGAAAAAAGCGCGGGCAAAGGCGAGTCCCTACCAGAGCCCACTGTCCTTC GAGCAGGTNCACACGGCCACACCTGGGGAAGACAGAAGCTCAGTGTTGTGATCGTCAGA

GTGGTCCCTTGGCTGGGGTCTCTGCTGCCTGGGCGCAGAGGGGNTTCTATGCTATAAGGCA GGCGGCTGGCGCGTGCCAGAGACGGCCACGACTTACCATCACGGGAAAGAGCTGTTAGG GGAACCAGACATTAAACAAAAAGAACGGGTGGGGGAGGCGGGCA >'000203a-024.scf came from CONTIG 23 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-024.scf*(l>602)

CGCCGCCGCTTAAACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGATTACAAGCG GATAGAAGGGCTAAAAATCAAAGGCGAAGAGTTCATATGACTCTGGAGTTACCATGGAGT GCTGATAGAGCAATTCAGCAATTTGGACGAACTCATAGATCAAATCAAGTTACCGCTCCT GAATATGTCTTTCTGATTTTCTGATTGGCAGAAGAACAAAGATTTGCATCTATTGTTGGTA

AAAGACTTGAGAGTTTGGGCGCACCTACACATGGAGACAGAAGAGCAACAAAAACTAGA AAACCGAGCCGCGTCCACCTTCGATAATAAGATGGAAGAAAAGCTTTAAAAATTGTGATG AAATCCAATGTGAAACCAAATTCTTCCTTGGTTCACCACTCCAGACTATCCTGGAGATTCT TTAAGAGTTCGCAAGACTGATAGAGTGTCTTATAAAGTGAAAAAGTCAGAATCTTCTTTTA TAAAATTTAAAACAAAGNAAATTTTAACAATTTGGGCGGGAGGGCCCACAAAGCCTTTTT

TTTTCGCACCCCTCCTGCGGCTCAAAGCAAAAAAGAAAAACATAGGAATTAATGTTGTTG

>'000203a-025.scf came from CONTIG 24 at offset 0;Ε:\SEQUENCE\export\EST_db\000203a\000203a-025.scf'(29>176) GGGCTGCAGCTCCATGGGGTGTTGGTGCCTGCCAGCCACGGAGGCCGGGCGGCCAGAACG

CGCACAGAGGGATATGATATGGTCCGGTGTGATGGAGAGAGCAAGCGGGACCGTGCAGC CTCCCAGGACACTGGCCCCGCGGGGAGCC

>'000203a-065.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-065.scf'(l>665)

GTGGCGCCCTCTAAACTATGGATCCCCGGGCTGCAGGTGGACTACACCATCACTGTCTATG CTGTCACCGGCCGGGGGACAGCCCGGCAAGCAGCAAGCCCGTTTCCATCAATTACCGAAC AGAAATTGACAAACCATCCCAGATGCAAGTGACTGATGTCCAAGACAACAGCATTAGTGT CAGGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTGACCACTGCTCCTAAAAAT GGCCCAGGACCATCGAAAACGAAAACTGTAGGTCCAGATCAAACAGAAATGACAATTGA

AGGGCTGCAGCCCACAGTGGAGTATGTGGTCAGTGTCTATGCTCAGAATCAAAACGGAGA GAGTCAGCCTCTGGTTCAGACAAGCGTTACCCACCATTTCTGCACCAACCAACTGAAATTN ACTCAGTGACACCACCAGCTGACTGCCAGGACGCACCNATGTCACTCACTGGTTCGAGGC GGNGACCCGAGAAAGACGNACGAGAAGAATCACCTGCTCTGAACTATCGGTTGTTCAGAC TAGTTGCACCAATGAGGAGGCTTGCTTTAGACCTGACACAACGCTAGGAGGTCAATTGAA

AGCACTCAAAGGCCGGGAAAGTTGAACACTCCTTATGAACAAATGAAAACGGTCAGTGGC TCC

>'000203a-026.scf came from CONTIG 25 at offset 40;"E:\SEQUENCE\export\EST_db\000203a\000203a-026.scf'(38>628)

AATTCGCACGAGTGTCTATGCTGTCCCGGCCGGGGGACAGCCCGGCAAGCAGCAAGCCCG TTTCCATCAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACTGATGTCC AAGACAACAGCATTAGTGTCAGGTGGCTGCCCTCAAGTTCCCCTGTTACTGGTTACAGAGT GACCACTGCTCCTAATAATGGCCCCAGACCATCGAAAACGAAAACTGTAGGTCCAGATCA AACAGAAATGACAANTGAAAGCTTGCAGCCCACAGTGGAGTATGTGGTCAGTGGCTATGC TCAAAATTCAAAACGAGAGAGTCAGCCTCTGGGTCAAACAGCGGAACCACCATTCCTGCA CCACCCACCTGAATTACTCAGNGAAACCAACAGCTGACTGCCCAGGNACGCACCCATTTC ACTCACTGTTCGAGGCGGTGACCCGAAGAGAGACGNACGAGAAAAATCACCTGCTCTGAA CTATCGGGTGTATAGACTAGTTGCACAAATTAGGAGGCTAGTCTAGACCTGAAGCAACGC

TCAGATGTACATTGAAAGAGCCTCAAAGCCGGGAAAGCTTGAACCCTACA

>'000203a-027.scf came from CONTIG 26 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-027.scf'(30>646) CTGCAGAAATTCGGCACGAGGAGCGAGTCCTGTTAGGTGCGCGTGGAAACTAGGGTCATG

GCTGCGCCCGGTCCAGCGCTCTGCCTTTTCGACGTGGACGGGACCCTGACGGCCCCGCGG CAGAAAATTACCAAAGACATGGATTGCTTTCTGCAAAAACTGAGGCAGAAAATCAAAATT GGTGTCGTCGGCGGGTCGGACTTTGAGAAAGTACAGGAGCAGCTGGGAGATGACGTTATT AAAAAATATGATTACGTGTTTCCAGAAAATGGCTTGGTAGCATACAGAGATGGGAAACTC TTGTGTAAACAGAATATTTAAGGTCACCTGGGTGAAACCCTAATCAAGATATATTCACTAC

TGTCTGAGCTACATCGCGAAAAATCAGCTCCNGAAAAAAAGGNCACTTCATAGAGTCCGT AACGTGAGCTGACGTGTCGCCGACGGAAAAGCTGCAGCAGAANAACCATGTATCTACGAC TGTACAAAAGAAACATAAACAAAGTCGGAGNATTGCAAAGATTGCTGTAAGGCTACGTTT CTAGAGNCAATCACTTATTCTCCCTAGCTGAACAATACGCTGGAACGGGAAGAAGATAAA CTTATTTTTGGACAAC

>'000203a-028.scf came from CONTIG 27 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-028.scf'(40>622)

CACGTAGGGGCGACCGCAGGCCCTCTCCCGAGGAGCTGGACAAGGGCATCGACCCCGAG AGCCCCCTGTTTCAGGCCATTCTGGACAACCCCGTGGTGCAGCTGGGCCTGACCAACCCG

AAGACCTTACTAGCATTTGAAGACATGCTCGAGAACCCGCTGAACAGCACCCAGTGGATG AACGACCCGGAGACGGGCCCGGGCATGCTGCAGATCTCAGAATCTTCCAGACCCTGAACC GCACATATGCCGCGCACTGCAGCTGCCAGCCCAGAGAGCCTCTTCTTCCCAGCCCAGGGG TGGGGAGAGGGTGCAGACCCCAAGGTGCGCCTGGGCTGGGGGCGGGGAGCAGGGGGGCN TGGAGGGACCCTGCCCCTGGGTGTGGCGCCAGGCCGCACTCCGCTGGATCTTCTGGAAAA

ACTCGGNGGCAGGGCCGGGTGGCTCCACCCCTGACAGGTTACGACAGGCGCCACCGGGA AGGGGGCTCCTTCAGGCCCTGGCTCTGACGTATTGATTAACGAGCGCGCTGGAAGACCTG TTTGAAAAAGAATGTCAACCAGTTAGGAAGGATAATGGGAAAAAAA >'000203a-029.scf came from CONTIG 28 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-029.scf'(35>595)

AATTCGCACGAGGTCATCCCTAAGTGGCCTGAAGATGGACAAAGGGAAGTAACAGGCAC GTGATGTTGGCAAGGATGCTTCTAGGGCTAGAGGATCAGTGGTGGGAGAGAGCTGCAGAA TCCACCAGCCAGAACTGCAGATAACGATATCTATGGTCAGGGGCTGTGACTGAGAGAAGG AAACTGAGGTTGTGTTCTGAAAGTACATAAACTCTCACATATACCCAGTTCTTCACCATCT

TCCCTCCTCACTTTGCAGNGCCATTTTTTTTTTGCATTAGGCAAATTGCTCAGACT^ AGCCATGCCCATCCCGTCTCTGGAACCCCCACACCTCTGAGAGTGGGATCACCACGTCCTG CAGGGCTGCTCCCCTCCAACTACCTTTAGAGAGCAGGACAGGAGCTGTTTCACCACAAGA CAAAATCAAACGAGAGCAGACGGGTAAACAAANAAGACAGGGGCAATGTTTTCTTGNGT TTTGTTTTTTTTCCATTGGAGGTGACACAAAAATTCAAGCTACAGTTCCCCTCTCCCCCCCA

TTTTTTTTTAACAAANA

>'000203a-030.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-030.scf'(36>676) CTCATCCTACCATATAGATATTGGTACCCTTTATCTACTATTTGGTGCTTGGGCCGGTATAG

TAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGGAACTCTGCTCGG AGACGACCAAATCTACAACGTAGTTGTAACCGCACACGCATTTGTAATAATCTTCTTCATA GTAATACCAATCATAATTGGAGGATTCGGNAACTGACTTGTTCCCCTAATATTTGGTGCTC CCGATATAGCATTTCCCCGAATAAATAAATAAGCTTCTGACTCCTCCCTCCCTCATTCTACT ACTCCTCGCATCCTTATAATTGAAGCTGAGGCAGAAACAGCTGAACCGNGNACCCCTCCT

TANNCAGCAACCTACCATGCAGGAGCTNATAGAACTACCATTTCTTTTCACTTACANGAGT CCTCATTTTAGAGCATCAACTCTTACACAATACAACATAAGCCCCGCATGCCATACAACCC TTGTGTTGATCGNATATACGCGACTATATATTGCTCTTITACACGCACCAGCTTTAAACGA ACTATCACTCTCACGCGAGAGAACTTTTTTACAT^ GGGATTCTTTGCCCCTCAAAAAAACAGTA

>'000203a-031.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-031.scf (13>195)

TACTATGGATCCCCGGGCTGCAGGNAGTTTTTTTTTTTTTTTT^

TTATTACATAAATAAAAGCAGCACGCTTTTATTTTCTATTTAAATACCATACACGAGATTT

AAAATCACATTTGGCAGTGGACTGCAGGATGCTCAGACTTCACCCACATCACNTTGGATT >'000203a-033.scf came from (F3, 033) no description length

779GGCGCCCTCTAAATATGGATCCCCGGGCTGCAGGAATTCGGCACGAGGCCGGACCGGT

GTCCTTCTCTGGAGGCTCCTCGCTGGTCGTGGGGGAGCCGGGAGGGCATGGCTGGCTGCC

CGAAAGAGACTGCGAGACGGTGACCTGCTGTCTCTTTTCGGAGCGGGACGCCGCCGGAGC TCCCCGAGAAGCCGGCGAACCCCTGGTCGGGGCGGCCCTAGAGCCAGAGGCGGTGGGCG

GGAGCGCGAAGCCCGCTCGCGGGTGCTGCTGCTGTAGCAGGAACTCAAGATGGTCACGAT CTCGCTGCTGAAGCGGCTCAAGGAACGCTCGTTGGCCACGCTGCTGGAGGGGGGAGACCC GCGGGGGGGGCCGGGCGGCTGCGGGCTGTGCCCGCCGCCGACCTCCCCTGGCGGCCACCC CGCCGCGCACTGGTGTCGGACCCCCTCCCTGGCCCACCTCAGCCGCCGGGGCCCAGCCCT GGCGGGGTCCACTCCCCCCCCCCGAGGCCCCAGGGCCGCACCCCACCCTCACCGCTCGGG

GCCAAATACCGCCCGCCTACCTGTTTCCCCGGACAACAACACGATTATTATCCCTTGCTAA TGAAAAACGCCCCCTTTCATCCGGAATCAACCACTGCCGCCCCCACCACCTGGCGGGGCT GTACGGCGGGGGGCTCCCTCCCCCCCCCCATTTCTCTCTTTTTTTTCGTCTCATTACATTTG GGGGCTATATATATAATATATTATTATAGATATTATTTTIΠTTTCTATCTATATTTTTA

>'000203a-034.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-034.scf'(28>623)

GGGCTGCAGAATTCGCACGAGGCTGTCTGCTCGTGGTGGAGATGGCAGTAGGATCATTTT TGATGATTTTCGAGAAGCGTACTATTGGCTTCGTCACAATACTCCAGAGGATGCGAAGGTC ATGTCATGGTGGGATTATGGCTACCAGATTACAGCTATGGCGAATCGGACGATTTTAGTG

GATAATAACACGTGGAATAATACCCATATATCTCGAGTAGGGCAGGCCATGGCATCCACA GAAGAAAAAGCCTATGAGATCATGAAGGAGCTTGATGTCAGCTATGTGCTGGTCATTTTT GGNAGCCTCACTGGGATTCTTCAAATGACATCAACAAATTTCTGTGGATGGGCCGGATTG GAAGGAGCACAGATACAGGAAACACATACAGGACACGATATTATACTCCACTGGNGATTC GNGTGGACCCGGAGGCTCCCANGCTGCTCACTGCTTTAGACAAAAGGGTACTACGATTGA

CAGGNTACCAAAACCACGGCCCTAGCTTTACCGGCCGGATGCGAGATGGAATAAACTCGA CTGAGTCTAAAAACAACACACCACATGCTGGCGAATTCAAGGAGACCGNAATCAG

>'000203a-046.scf came from CONTIG 32 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-046.scf'(37>597)

NAATTCGGCACGAGGGCATGAATGTCCTGGCCGATGCTCTCAAGAGTATCAACAATGCCG AAAAGAGAGGCAAACGCCAGGTCCTTATTAGGCCGTGCTCCAAAGTCATCGTCAGGTTTC TAACAGTGATGATGAAGCATGANTACATTGACGAATNTGAAATCATTGATGANTCACAGA GCTGGAAAATTGGTGNGAACCTCACNAGCAGGGCTAATAAGTGTGGAGNGATCAGCCCTA GATTGATGTGCAACTCAAAGATCTAGAAAATGGCAGAATACCTGCTCCATCCCGCAGTTG

GTTTCATGTACTGACAACTCAGCTGCATCATGGACATGAAGAGCAAGACGAAACATACAG AGGAAATCTTGATTCTTTTTAGGAGTATACTACAATAATGCTCAAGACTTGTGCTTCTTAA AAAAAAAAAAAAAACGACCGCACTGATGACAGATCTACATATTCTGACCTTTTTATCTCA CTAAAGTCAACCACTTTTCCATCAACGAACACAAAATAAAAAAAACCCTGAAAAAAAAA AATTTTTITTTTTTCTTTTTT

>'000203a-035.scf came from CONTIG 32 at offset 542;"E:\SEQUENCE\export\EST_db\000203a\000203a-035.scf'(38>379) TTTTTTTTTTTTCCTTTCTC ATTTTCTTTAAATTCGACACAGTTATGTTAAAAAATATATGCATTGTACTTAGAGTTTGGT

GTAATTTAAAATATGTGGAGTGATTTCATTCACTCTCCTGTTTTAAACATTTGTTAAGGACT CAGCATGTGAAGGAGCAAGAGATATAGTCATTTI ATTAGAAAACTTCAGTGTTCTAATTT CATCAGAGACCGNGAATAATCAGAAGATGACATGATTTACTTGGAATATACAGCTTATCA AGGACTTCGTTATTTATGATGGTTATTTAAAATC >'000203a-037.scf came from CONTIG 33 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-037.scf'(37>554)

CGCAGCCACTCCGACCGGTGCCGCCTCGTCCTGCTTCGCCATGACTTCCTACAGCTATCGC CAGTCGTCGTCCACCTCGTCCTTCGGGGGTATGGGCGGCGGCTCCATGCGCTTCGGGGCTG

GGAAGCGCCTTCCGCGCGCCCAGCATCCATGGNGGCTCAAGTGGCCGCGGCGTGTCGGTG TCCTCCGCCCGCTTCGTGTCCTCGTCCTCCGGGGGCTACGGCGGCGGCTATGGGGCGCCCT GGCCACCTTCGACGGGCTGCTGGCGGGCAACGAGAAACTCACCATGCAAAACCTCACGAC CGCCTGGCCTCCTACCCTGAGAAGTGCGCGCCCTGGAGAGCCAACAGCGATTGGAGTGAA AATCGCGACTGGACCAAAACAAGGCCGGCCCGCCGCGACTACACCTACTCAAACATAAGA

CTGCGNACCAACTCGTGGCACATGAAACTCATAATCTGCATACACAGCCGTCGCTGCAAG ACTCGCACATTGAGACGACAGCTGGCAGAGGGAGC

>'000203a-038.scf came from CONTIG 34 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-038.scf'(38>594)

NAATTCGGCACGAGGAGCAGATCCTGGCTGCCCTCGAGAAAGGCTGCAGCTTCCTGCCGG ACCAGTACCGCAAGCAGTGTGACCAGTTTGTGACGGAGTATGAGCCAGTGCTGATAGAAA TCCTGGTGGAGGGGATGGACCCTTCCTTCGTGTGCTTGAAGATTGGAGCCTGCCCAGCAAC CCACAAGCCGCTTTTGGGAGCTGAGAAATGTGTCTGGGGCCCGACCTTACTGGTGCCAGA ACATGGAGTCGCAGCCCTGTGCACCGCGTCGAGCACTGCAGCGTCACGNGTGAAACTAGG

GCACGCTTCACCCTGAAAAACTGCAGCGTCTTTTCTGCTCGGTTGTCTGGGGTAACCACAC CAATTGTGACTTTGTATAAAAAAGACCCTTCCTCATCCTTNTTCTCCCTCTTGTGCGTGCTT GCAGGCAGTGACTGCTGTTTCGTCCTTTTTGTAAAAAGCGAACCTCCTGAGTTTTGATTGT GGCGGGGTAGGGGAAAGGGTTGTCGGAGGAACGACCTCGCGAGGCCGCCCCGCTGTTGG GGGGGCCTGCGCT

>'000203a-040.scf came from CONTIG 35 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-040.scf'(29>585)

GGGCTGCAGGTTAATTCATTTTTCTGGAAAAAGAGAAGATGTTTATTTATTTATTTTTCCAT GGTAAATTCTTTTGAATCTGCCTCTTAAACCTAACTCTGGGCTCTCTCAGGAGGGGCAAAG

AGGACCTTTGAGTTAAACCCTCCAATGGAGACCCTGGGAAAGAACCGGAGGCATAACACC CNAGCCGCCCTCCAACTGGACTGTANGACTCCCCAGACCCGCTGCCCAGCTGCTTCTGCCC ATCGNTCTGCCTGGTTGGGTTNTGGGTCCTGGATCCCACCCGAGCCCTGTAGGATGGCACC ACAAGCCCTACATGAAGAGCTTTGTGGTGTCACTAAAATGTGTGTTTCGGCACGTTGCTGT CATTCTGCCTGNCTGCCATGCTGAAAAGCTGGCACAGCCCGANAAGCCAGCGAAAACACC

TTCTGCCAGANCTCTGNCCCACTCGAGATGAGACCACCAGCTGCTGTCCTCCCAGAACAG GTATTATATTTAAGTAAAACTGTTACTAAAAAGTTTGTTCCAACTTATTCAAAACAAGAGA AAAGGGGCGT >'000203a-041.scf came from CONTIG 36 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-041.scf'(l>593)

GGGGCCCTCTAAACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGCGGACCTGCTG GAGCTCCTGGCACTCCTGGACCTCAGGTATTGCTGGACAGCGTGGTGTGGTCGGCCTGCCT GGTCAGAGAGGAGAAAGAGGCTTCCCTGGTCTTCCTGGCCCCTCTGGTGAACCCGGCAAA NCAGGTCCTTCTGGAGCAAGTGGTGAACGTGGCCCCCCTGGTCCCATGGGCCCCCCTGGA

TTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTCCTGGTGCTGAANGATCCCCT GGACGAGATGGTTCTCTGGCGCCAAGGNTGACGNNGTGAGACCGNCCCTGCTGACTCCTG TGCTCCTGCGCTCCCGGGCCCCCGNCCCTGTCGACTGCCGCAGACGNNGACGGGTGAGAC GGCCTGCTGTCTGCTGTCCCATGCCCGTTGTGCCGGGCCCGTGNACCCAGCCCCCGGGACA GGTGAAAGCGACAGGGACGAGCATAAGTCACGNGCTCTTGTCTCAGTCCCCGCCTCCGCT

TCTGGAGCAGTCTTCGACTTGTCTGTGGCCGCGCCCCGTTTTGTTCTCGCA

>'000203a-047.scf came from CONTIG 36 at offset 42;"E:\SEQUENCE\export\EST_db\000203a\000203a-047.scf'(41>502) CACGAGGACGGACCTGCTGGAGCTCCTGGCACTCCTGGACCTCAAGGTATTGCTGGACAG

CGTGGTGTGGTCGGCCTGCCTGGTCAGAGAGGAGAAAGAGGCTTCCCTGGTCTTCCTGGC CCCTCTGGTGAACCCGGCAAACAAGGTCCTTCTGGAGCAAGTGGTGAACGTGGCCCCCCT GGTCCCATGGNNCCCCCTGNATTGTCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCT NCTGGTGCTGAAGGATCCCCTGGACGANATTGTTCTCCTGGCGCAAAGGTGACCGTGGTG AGAACCGGCCCTGCTGACCCTCTGTGCTCCTGCGCTCCCGTGCCCCCGNCCNTGTCGACTG CCGCAGACGTGATCGTGGTGAAACAGGCTGCTGTCTGCTGTCCATGNCCNGTGTGCCNGG NCCCCTGNACCCAGACCCGGTGACAGGGAAAAGCAACAACG >'000203a-042.scf came from CONTIG 37 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-042.scf'(l>652)

CGGCGTCCCTCTANACTATGGATCCCCGGGCTGCAGTGGTTCTGCAGCTCTGTGGCAAGCC GCGGAGTCTGGGTTCTGATCCGCAGGATGGGGTTTGTTAAAGTTGTCAAGAACAAGGCCT ACTTCAAGAGATACCAAGTGAAATTCAGAAGAAGGCGAGAGGGCAAAACTGACTACTAT GCTCGGAAACGATTGGTAATCCAAGATAAAAATAAGTACAACACACCTAAATACAGAATG

ATTGTTCGTGTAACGAACAGAGATATCATTTGTCAGATTGCTTATGCCCGTATAGAAGGAG ATATGATAGGTTGTGCAGCTTATGCTCACGAACTCCCAAATATGGNGTGAAGGNTGGCCT GACAATTATGCTGCGCATATTGTACTGGCCTGCTGCTGCCCCGCAGCTTCTTTATAGGTTG GATGGACAAAATTATGAAGCNAGACGAGGNGATGGAGAGATACATGNGNAAGCATCGAG CCAACTGGGCCTCACTGTACTGNAGCAGACTGCAAACTCTACGAGTTAAGTTTGGCCCTA

GGACGCGAGAGCTGCTTTCTACAGACACGTCCTGTTGATCAAAGCAAATCAGCGAGCCCG AAGCATAGGCAAAGTGAATACGCCCCTGTGGAAAAAATCCAAAACTTTTCA

>'000203a-044.scf came from CONTIG 38 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-044.scf'(l>627)

CGGCGCCCCTCTACAACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGCAGGACAA TCAAGTGTGGCAGCTGGGCTCATCGTCCCCAAACTTCACTCTGGAGGGACATGAGAAAGG TGTGAATTGCATTGATTACTACAGGGATGGTGACAAGCCATACCTCATCTCTAGAGCAGAT GACCGTCTTGTGAAAATATGGACTATCAGAATAAACTTGTGTACAGACACTGGAGAGGAC ATGCCCCAAATGTGTCTTGTGCCCAGTTCATCCTGAGCTGCCCATTTTATCACAANTTCAA

AAAATGAAACTGGCGTTTTGGCATTCAAGCACCTTCGCCTTGAGAGGACTTGATTATGAAT GGAGAAGAGATGGGGGGGCCGCCGCGAGGTCCATAACGTGTTTTGGCTTTGAGAAAGAA GCATATGTTAACTTGTCGGAGAACTGCTTGTCTGGTGCCAAGGAAAATAATGGGCCAACA TCAAAATCACCAGCCACTAAACAAGGAGAGTGTAATTAAAGAAAAGATGCCTGCATAAA AATGCAGTTGAATTACTCAATATCACAATCTAAGCGCGGTGGGGGGGGGGGGGAAATTTT

TCCGCAGCCCGAAACAATGTGGGCCG

>'000203a-045.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-045.scf^,(44>624) GCACGAGGCTTGCCTGCTGCCTGCCTGCCTGCCACTGAGGGTTCCCAGCACCATGAGGGC

CTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAACAGCAAGCC TTGCCTGATGAGACAGAAGTGGTGGAAGAAACCGTGGCCGAGGTGGCCGAGGTACCCGT GGGAGCCAACCeCGTCCCAGGGGAAATAAGAAGAATCGATGATGGTGCCGAGGAAACCG AGGGGAGAGTGGGGANCGAGAACCCCCGCCAAACCACCACTGCAACACGGCAGGNGTGT GAACTGAACGAGAACACACCCCATGGTGTTGGCCAGACCCCACCACTGCCCTGCCCNTCG

CGAAGTTGAGAGTGTGCACAACGACAACAGACTTCGATCCCTGCCATTTTTGCACNAGGN ACATGNAGGCACCAAAAGGCCCAACTCACTGNCTACTCGGCCTGAATACATCCCCTGCTG CATCGACTGATGATCCTGGCTGCGACGCTAAACGCCGNCACTGACAAGGAAGCACACTCG ACGAAAATATGGATGAAAAACCAAATAAAGCCGGGGGGGCCTC

>'000203a-048.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-048.scf'(38>559)

TTATACTCCAAGGCCTGGCAAAATCACATAATCAAGATTGAATTGTTTCAGAAATATTGGC AGGATTCTTGGACTGTGTCTACTACAGAATGAACTGTGTCCTATCACATTGAATAGACATG TGATTAAAGTGTTGCTTGGTAGGAAAGTCAATTGGCACGATTTTGCTTTTTTTGACCCTGT

GATGTACGAGAAGTTGCGGGCACTTATTCTTGCTTCTCANAGTTCAGATGCTGATGCTGTT TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTTAAGAGAAGAGGGGAGACAGN TGAACTATTTNCTATGTGTAATATACCAGTCACTCTCAAATGTTATGAGTATGTGCGGAAT ATGCTGACATAAATGTNNGTAGTGCAGACACCATACTGCATGAGAAGTCTCTGNTGTGCT TCAAAATCATATANATTACACAGAAATTAGCTTTGTTAGCTGGNGAGNTACGGCGAGCGT

CAGTCACTCTTCTGAGATAGAAAAGTGAACTTGCGTC

>'000203a-049.scf came from CONTIG 41 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-049.scf'(l>306) GGGCGCCCTTAAATAGGATCCCCGGCCTCAGGGTGGCAAGAGGCCGTGCTATTTTTTTTTT TGTAGAAGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAACGAGTTTCTCACTCGGGA GCTGGCTGAAGATGGGTACTCTGGAGTTGAGGTCCGAGTTACACCAACCAGGACAGAAAT CATTATCTTGGNCCACCAGACACAGAATGTACTTGGTGAGAAGGGCCGGCGGATCCGGGA ATTGACTGCTGTGGTTCAGAAGAGATTTGGCTTCCCTGAAGCAGTGTAAAGCTTATGCTGA

AAA

>O00203a-050.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-050.scf'(39>525) NAATTCGGCACGAGGCTAGTCTCGAGTTTTTTTTTTTTTTT^^

TGCTTTATTTCATTTTTTTCACAATTTATTTAAACATCTCACATATACAAAATAGGTACA^ TTAATTTTTCTGCTTGTCCGAGAAACAAGACTTCTTTGGAACCATGGNAGAGGATGAAAAT GAGACTGGCAAAGAACAAATGCTGAANTTAAAGAAGAGACAANTGTGGGCAAATGATCC ACTTACTTTTGTGGAATAAGATGTAAAGTACTGATGTTAAAGTCAAATGAAAAAAATACA CAATACAGCTCAACAGCAGAGGAGTATCTCTTCTCAAATTCTCCTAGCACCATCAACATTC

TTNCAGTATCTGAAATACTGTTAATTAGCACCTTCGTATTTTGAACNAAAAAACACAAATA CCTCAGCTCATCTCTGGTCAGCACTCACGGTGTGGTATCACACTCACAGGAAANGTTTTGA

>'000203a-051.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-051.scf '(38>406)

NAATTCGGCACGAGGATCATATAGTAAACCCAAGCCCTTGACCTCTTACAGGAGCTTTGTC TGCCCTCTTAATAACATCCGGCCTAACCATGTGATTTCACTTTAACTCAATGACCCTGCTA ATAATTGGCCTAACAACAAATATACTAACAATATACCAATGATGACGAGATGTTATCCGA GAAAGCACCTTTCCAGGGGCACATACCCCAGCTGTCCAAAAAAGCCTCCGTTATGAATAT TCTTTTTATTATCTCCAAGTACTATTCTTTACCGATTTTTTTGAGCTTπ

GCCCCACCCCTGACCTAGCGCTGCTGACCCCCACACGCATTCACCCACTAACCCCTACAAG TCC

>'000203a-053.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-053.scf'(37>515)

TGAGAGCAGCAGCCAAAAACCACGCTCGAGTGACAGTAGTATGTGAGCCGGAGGACTAT GCAGCTGTAGCCTCAGAGATGCAGGATTCTGACAGCAAAGACACGTCCTTGGAGACAAGA CGCCAGTTAGCCTTGAAGGCTTTTACTCATACAGCACAGTATGATGAAGCAATTTCAGATT ACTTCAGGAAAGAGTACAGTAAAGGAGTATCTCAGATGCCCCCTGAGTATGGAATGAANC CTCATCAGACTCCTGCCCAGCTGTATACGCTGAAGCCCAAGCTCCNTTATCACAGTCTGAA

TGGAGCCCNTGATTTATAANCTGGGTGATGCTTTGAATGCCTGCAGCTGGTGAAGGAACT CNAAGAGCTTTTAGCTTNCACTGCTGCGTCTTCAAACATGTAGCCCACAGGCTGCTGTTGG ATTCACTCATGAAGAGAAACCACTCTGCATGTTATGATTGTACAAACCTCCACCGCA >'000203a-054.scf came from CONTIG 45 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-054.scf'(40>404)

CCTAAATTACTCAATAGTTTTAAAGTGTTACATATTCAAAGCCTTTTCCAGACCAGGGAGA GAGTTCTGTTAGAGTGAAGGGTAGTGTCTCTTGCGCATTCTGTGTGTGTATTTCTAAATGC TACTGTGTGTGTTTGTGTGTGCTCCCACAGTTTATATGCAAAGACTTTGAGCAACATTTAT AAAAAGTATTTTCTCTTAGAACAATTCAAGAGATTTATTTTGTGGCTACCACAGNCACTGC

CAGTGGATTGTTTTTTCTTCTAAATCTGAATATTGACCAAAAATTTGGTGATTTTTATGACT TTGTTGTGTTGGTGTTTAATTTTCTTAAAAAT^

>'000203a-O55.scf came from CONTIG 46 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-055.scf'(l>728)

GTGCCTCTCCCTATACTATGTATCCCCGCGCTGCAGTATATTTTGCATGTAGGAGAACATG TAATCTCTATCTTCCCTTAGCAGGATCAAACCTAGGGCCTTCTGCATTGCGAGCACAGAAG CCTATCCTCTGGACCACTTGGGGGAGTCCCCGCTITΓCTTTGCATCCCAAAGAATATTATA ACTAACCTAAAGAAAACCGCATTTTCCCCTTATCGGCGCGCTTCTTTCCTTTAGTCTAAGA CAATAATGTCTTATTGTCCTGGGGGGGACATAGTCAGTACGGGTTAAGCTCCTCTAACCTT

TGGTGGCATTTTTTGCCCCAAATATTGCTTTTC^

AAATTCCTTCTGCCGCCCCCCACTTGGGGGTGGGTTGGCCTCTTGGGTCTTTTCTTAATAAT AAAACAAAACGGTTTGACTGTGTCTCCCCCAGGTACTTTTTTTTCTCTCTTTCAGAGTACTG TCAACCGGACTCCAGTTTTCTCCTGGGACGTCAAATTTTCCTACTCTCATCGCCTCTGCTGT GGCCTTTTTCCATTTCAAGAAATTCTCGACCTATTATTCACTCCTTAAAAAATATATCATGC CCCCCCCCTCTACTTGCTTCGCGACAGACACAACAATTTTCTTCTAAGCAGGCGAACCACA ACAGAATAGGAAGATATCTATACAGAAGGAAAGAACGTATTCATGGCGATCT >'000203a-056.scf came from CONTIG 47 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-056.scf'(17>140)

TCAGGGATCCCCGGGCTGTCAGCTGCGTCAAGTGTTGTCATGAATGTTTTCCTGGGCCTGG CGGCGACTACAGCGGTGCTGTTCTGTCCTGTCGCGGGCTGCGGTGACTCGCTGGCGGCTCT TC

>'000203a-057.scf came from CONTIG 48 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-057.scf'(10>722)

CTCTATACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGAGGTATGTCTGAATGTG TTTCGACTATTTACAGCCCCCTTTCCTCGCAGGGCCCCATGAGTAAGCTGTGGCGGCGCGG GAGCACCTCTGGGGCTATGGAGGCCCCTGAGCCTGGGGAAGCCCTGGAGTTGAGTCTAGC

GGGTGCCCACGGCCACGGAGTGCACAAGAAAAAGCACAAGAAACACATGAAGAAACACA AGATAAAACACTACCAGGATGAAGAGGCTGGGCCAACGCAGCAGTCTCCTGCCAAGCCCC AGCTCATACTCAAATCAAGTTGGGCGGGCAGGTCTTGGGCACCAAGAGTGTTCCTACCTTC ACTGTGATCCCTGAGGTCCTCGCTCACCCCTCTCCCTTATGTNTGGGAACATGAAGAGTAC CTGTGAAGGAGCCCCCTGACATACCGCGCTGCTGGAGAAACAAAACTGCCCCTCCCATGG

GNACTGCTGNGGNTANAGCCAGAGAAGAGAATACGAGGGCTGAGCTTGNAAAGGGAGCG AGACAGAAACCAAAGAAACAGACGCTGCACGTGCAGAGTTGTGAAGCCGAGCACTCCGG TGCCTCTGCTGGCTGCGGCCCTTACAAAAGGGGAGGGGGGGCGGAAGGGGGGGAGGGGC GGGAAAAAAAAAAACCCCAAGAGCGGGGGGGGGGGCGGGGGGGGGGGGGCCCCG

>'000203a-058.scf came from CONTIG 49 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-058.scf'(38>620)

NAAAGACTTCATGAAGGAGAAGAAAAGGAAAAAAATCAAAGGATGACTACAGCCTCTCT TCATCTCAGCTTTGCAAAGCATGACTCAACAGAGAGATCACATTCTTGAAGACTCTCCAGA CCACAGATTGAAGATAAGTTGTTGTGCTGCACTATTTCTGTTGCTACTCGTGAGAGTCACT

ACCAGCCTCTCTTCTCAGGATTAATGAATGGGCCAGAAACCGGGGGCAGAATGACTNCAG GGGCACCCCCAACACCAGATATTGGCATAAGGAAACAGTACAATGAAAAAAGTCATACTT GGACCCTTGTCATTCCACANAGCATGATGTACTATCTAAAACAAAAAGAAGAGCTGCTTT GGAGAAGGGTTTTAAAAGTTGTTTATCAAAANAAAGATTANAAGAGGAAAACTCCAGTNT ATNAGATGGCATTTACTTTNAAGGCTCTGTCCCTGTGTAGGCATGAGATTGATACAGNACA

GACGGGCTGCCAANCAGNTACTAATGTNTCTGCTCTAAGAAGGGNCCTCTTGCTTCCTTGT GATATCTTGCAGAGCCGACTGAGGACAGAAACACAATAAG

>'000203a-059.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-059.scf'(39>620)

CAATTCGGCACGAGGGTGAGTGACATCGTCTTTAAACCCTGCGTGGCAATCCCTGACGCA CCGCCGTGATGCCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCA TCCAACTTCTGGATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAA GCAGATGCAGCAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAA CACGATGATGCGCAAGGCCATCCGAGGGCATCTGGAAACAACCCGCTCTGGAGAACTGTG

CCTCACACCGNGGAATGTGNNGCTCGGTCACCAAGAGACCTACTGAGACAGGACAGCTGC TGCCACAGGGCCACTGCGCCCGGCTGTGCATACGCCGGGAGACCTGGCCACCAGACATGN CTGGGCCGAAAGACTTCTCTCAGCTTAGCACACACGATACTCAGGCACAGAACCTGAGAG GCATGATAAAAGAACAGAGCGCAGAGCACGCGACACGACACCCCTTCCTGCGCCCCAAG GGGAAAGCAGATACCCAGCTAAAAAGACCGCTCCTCGGGGGG

>'000203a-083.scf came from CONTIG 50 at offset 7;"E:\SEQUENCE\export\EST_db\000203a\000203a-083.scf'(45>614)

GCACGAGGGTGACATCGTCTTTAAACCCTGCGTGGCAATCCCTGACGCACCGCCGTGATG CCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCATCCAACTTCTG

GATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAAGCAGATGCAG CAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAACACGATGATG CGCAAGGCCATCCGAGGGCATCTGGAAAACAACCCGGCTCTGGAGAAACTGTTGCCTCAC ATCCGGGGGAATGTTGGCTTCGTGTTCACCAAGGAGACCTCACTGAGATCAGGGACATGC TGCTGGCCAACAGTGCCAGCTGCGCCCGGCTGTGCCATACGCCGGTGAAGCCTGGCCAGC CAAACATGTCTGGGCCCGAGAGACCTCTCTTCAGCTTAGCACACAGAANATTCAGGCACA TGAAATCTGAGAGGCACGATAGAAGAACAAGAGCGCACGAGCAGCGTGACAGCGACACC CCTTTCTCGCGNATCACAGGTGACAGCAATT

>'000203a-060.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-060.scf'(l>262)

GGGCTAACAGTCCGCGAGCCCGGCAATCCGCAGCCGGGCCCACAGGAACATGCGTCTGCT TGGGGGGGAGAGGGCCGGGCTAGAGCGAGCAAGGTGAGGGGGGGGGGGGGGGACCTCC CGCGGATACAAGGTCACACACCCCTCCTAATGCAGAAGGCGACGGTTGCAGGAAGGGCA

AAATAAGGACTCGCAAGGTGTCTAGGGGAACGAGTAAATGAAAGGCCACGGCGCGAGAC GCGAGCGACCACCCAGGAGAACCGCG

>'000203a-061.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-061.scf'(39>494)

NAATTCGGCACGAGGGTGAGTTTCATTGAGTTAAATAAATACCTTTTGGAAAGGAGTTTG CCGATGCACCAAAAAAGCCTGTCTGCGCTGTAGGAATGTGTGGTGAAGCTCAATTTCTGTT TTATGAAACCTGTTTGGGCGGGGGTCTGGGGGTTGCACAGAGAATGAGTTCTTGTATTTCG CGTCACACAGGTAGTTATGGAAATATGTTATTGTACTGTGTAAAGATGCCCAGCCATTTTG ATTGTTTGGCTTTTTACTTTGTACCTTTTCAAGCTTTTGCTATACATCTGGA^

CATACTGTGTTGTACTTCCTTTTGTAATGATTTTTAATGGAAGTTTGCACATAACTCTTGTT

ATACTGTACGATAATCTTGGGGGAAAATATTTTGCATATCAAAAAAAAAAAAAAAAAAAA

ACCGAGGGGGCCCGCCCCCATTCCCCTTA >'000203a-062.scf came from CONTIG 53 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-062.scf'(l>630)

CGGGCGCCGTTAACTAGGTCCCCGGCTCAGCAGACACAGTGTCGTGAAAACCACCGTTAA ACCTAAGCCAAAATGGGAAAGGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTA GATTCAGGGAAGTCTACCACGACTGGCCATCTGATCTACAAATGTGGCGGGATCGACAAG AGAACAATTGAAAAGTTCGAGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCNAATA

TGCCTGGGTCTTGGACANACTTAAAGCTGAACGNGAGCGNGGNATCACCATTGATATCTC CCTGTGGAAATTTGAGACCAGCAAGTACTATGNTACCATCATTGATGCCCCAGGACACAG AGACTTCATCAAAAACATGATTACAGGCACATCCCCAGCTGACTGTGCTGTCCTGGTCGGT GCTGCTGGGTTGGNNGAATTGAAGCCGGATCTCCAAGACGGCAGACCCGNGAGCTGCCTT TTTGCTTACACCTGGNNGNGAAAACACTATTGTGCGNNTACAAAGGATNCACTGACACCT

ATACAGAGAATCAANAATGTTAGNANCACACTTATANAAATGCTCACCCGACANACATTG GCCATTTGCTGAAGGACAAGCTAACAAGCT

>'000203a-075.scf came from CONTIG 53 at offset 27;"E:\SEQUENCE\export\EST_db\000203a\000203a-075.scf'(41>615)

CGGGACACAGGTGTCGTGAAAACCACCGTTAAACCTAAGCCAAAATGGGAAAGGAGAAG ACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCAGGGAAGTCTACCACGACTGGC CATCTGATCTATAAATGTGGCGGGATCGACAAGAGAACAATTGAAAAGTTCGAGAAGGA GGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGGTCTTGGACAAACTTAAAG CTGAACGTGAGCGTGGTATCACCATTGATATCNTCCTGTGGNNAATTGAGACCAGCAGTA

CTATGNTACCATCATTGATGCCCCCAGACACAGAGACTTCATCANAAACATGATTACAGG CACATCCCAGCTGACTGTGCTGTCCTGATCGTGTGCTGTGNTGGNNGAATTGAGCCNGCAT CTCCAAGACGGCAGACCCGGAGCTGCCCTTTTGGCTACACCTGGTGTGAAAACACTATGTT GGCGTTACAATGGATNCACTGACACCTTANCAGAGAATCAANAAATGTAGAAGCAGACTA TTAAAAATGCTCACCCGACAGACTTGGCCATTTGT

>'000203a-063.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-063.scf'(10>605)

GCTCTATACTATGGATCCCCGGGCTGCAGCGTCACTTACCTCACTCGTTCGGAGTCGTATA TCGGGGGAAATTGCTACATTCTGTCAGGGTCACGTGATGCAACCCTTCTGCTCTGGTACTG

GAATGGAAAAAGCAGTGGTATTGGAGATAACCCGGGCAGTGAGACTGCCACTCCGCGGG CCATTCTGACAGGCCACGACTACGAGATCACTTGTGCTGCTGTCTGCGCGGAGCTCGGCCT CGTGCTAAGTGGCTCCAAAGAGGGACCATGTCTCATACATTCCATGAATGGNAGACTGNN TAGGGACTTGNAGGNTCCANAAAACTGCCTGAAACCAAANCTCATTCANGCGTCGAGAGA GGCCATTGTGTCATTTTTATGAAAATGGGCTCTCTGCACATCATGTAACGGAAAGCTCAGC CACATGGAACGACATACATAAGGCATCACTGACGGNATGGCAGACTGCTCACGGAGAAC AGGGGGCTCAGTCTGCGGGTCGACTAACATGTCGCTACAGTGGAGCGGATCGGCTGGCTG CTAACAAGGCGCTGTGCTCCTAGACACGTGTTCACATCACGGGACCAACACCCT

>'000203a-064.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-064.scf'(44>603)

GCACGAGGCCTGGACCCCCTGGTCCCCCAGGTCCTCCCAGCGGCGGCTACGACTTGAGCT TCCTGCCCCAGCCACCTCAAGAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATG ATGCCAATGTGGTCCGTGACCGTGACCTCGAGGTGGACACCACCCTCAAGAGCCTGAGCC

AGCAGATCGAGAACATCCGGAGCCCTGAAGGCAGCCGCAAGAACCCCGCCCGCACCTGC CGTGACCTCAAGAGTGCCACTCTGACTGGAAGATGCGAGATACTGGATTGACCCNCACCA NNGCTGCACCTGGATGCCATTAANNGTCTCTGCACATGGAACCGGTGAGACCTGGTATAC CCACTCAGCCANGTGGCCCATATAACTGTATATCACAGAACCCAGTAAAAAGCACGTCTG TACGGGAGACTGACGGCGATTCAGTCGATTGCGGCAGGGTCGACTGCGAGGGCATCATGA

TTCTGGCTGAGNCACGAGCTCAAAATACTACATGAGACAGGNCTATGACACAATGCACTA AAGCCGTCTCAGCTCAGATGA

>'000203a-066.scf came from CONTIG 56 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-066.scf'(39>329)

GTCTCAATGTCCGTGGCGCTGAGGCAAGCGTTGTGGGGGAGAAGGGTAGCGACTGTAGCT GCCGTTTCCGTTTCCAAGGTTTCGACCAGGTCGTTGAGCACTTCCACATGGAGGCTGGCAC AGGACCAAACTCGAGACACGCAACTCATAACAGTTGATGAAAAATTGGATATTACTACTA TAACTGGTGTTCCAGAAGAGCATATCAAAACTAGAAAAGCCAGATCTTTGGTCCTGCTCG NCATACATGCAGTCTGTAGTTAACAAACACAAGAATGGAGATGGAGGTTG

>'000203a-067.scf came from CONTIG 57 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-067.scf'(45>669)

GCACGAGTGGCGGATGACGCCGGTGCTGCGGGAGGGCCCGGAGGCCCCGGGGGCCCCGG AATGGGAGGCCGCGGTGGCTTCCGCGGAGGCTTCGGTAGTGGCGCCCGGGGCCGGGGTCG

CGGCCGGGGTCGGGGCCGGGGCAGAAGCCGCGGAGCTCGCGGAGGGCAAGGTCGAGGAC AAGGAGTGGCTCCCCGTTACCAAGCTGGGCCGCCTGGTCAAGACATGAAGATCAAGTCTT TTGAGGAGATCTACCTTTCTCTCTGCCTATCAAGAGGCTGAGATATTGACTTTTTTCCTGGG AGCATCCTTGAAGATGAGTTTTGAAGATTATGCCGGGCAAAACCAGACCCGGGCTGCCCA GGAACCAGTTCAAGGCGTTGTTGCTTTCGGGGATACAACGACTGGGGGCTGGTGGCAGGC

CCAAGAAAATACCCTGCCTCCGGGGGCCATCTTCTGCTAAGTGTCCACGCCCGGGCAAGA GCTTAGGGGAACANAAGACACCCCCCCGTCTGCAGGGACGGCTGGGTCCGGCGGGCCCTA CCTCCCAAGACGGCTCCTCGCCCGGCCAAACGGAGAGCGCTGACAGTCCTTGCCGGCGCT GCCCTGGCATCCAGCCTTGTCTCCA

>'000203a-068.scf came from CONTIG 58 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-068.scf'(40>680) TTTTTTTATGGCTTCTTCTTTCT^ TACACCGTTAAATAATTATTTAAAAACCAACCAGGATTAAGGCCCTGGCCCAGAGCTCCA AACCAGAAGCAGAAAGGAATGGTGGCGGTGGGCTGGGGGGGTATTCCTCCAACATCACC

AAAACCCAGAGAACGAGGATCCTAAGCTTTTCACAGGCCAACCCGGGCACGGGCCTGCAG GCTGACCCTCGGAGGCCTCTGGCTGCATCACTATCAGATCAAAACCAGCGAGGAGCTGCC GGGAACAGCCAGCCGAGTCCAGACATGGACACAGTAGCTGGATGGACACGAGACGGACA GGTCCTGTCCAGCTGTGGACAGGATTCAGATGCAAGCTAGGCAGTGGGGGCAGGGGCTGG GGAGCAGAATGAAGCATGCAGGAGGGGCCCCGGGGCCTGGCTCANCCACCGGCCGCCGA

GCCTCACCGTGTGGGNTCGCTGGGGNCTGGGCTCCCGCCCACACTGGACTTGAGGCTCTG NAGCGAGAGTTCCAGCCATTGTGATGTTGCTCTCACAACAAATNCTTGCCACTGGGAGAA TTGAGATGGTGACAAACTACGCCCAAGCATGTGGATGCCAGC >'000203a-069.scf came from CONTIG 59 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-069.scf'(12>643)

CTCTATACTAGGGATCCCCGGGCTGCAGTAATTCGGCACGAGGCTCGGTTTTTTTTTTTTπ TTTTGCTCTAATTAAAATTTTTATTGAAATCTCTCAAACGTTACCAAGAAATAGTTTπ AAAGGGAGGGAAGGGAAAAAACAAACAACAACAACAAAAAACAGCTAACAAGCAAATT CAACATGGGAGCTCCCTCTGCTGGTCTGCAGTAGGTTGATATGTTACAAACACATTCCCAG AGACAAATCTATTTGCTGGAGAAGGGACAAAAAACAGGTGTGTGGGCTTTGCCTCNAGAG AGAACACTGGCATGCAGNGAGCGGGGTAGTGAAAGCAGAGGAGCAGCGCAGCGCTAAGT CGCTGGTACAGAAGTACGGGCCACACTCAGGCTATGNGTAAAGGCAGCCTGTGACTCTAT GTCTCTGCATGACTGAGACAGGTGGCAAGNAACTGGGTTGGAGCCTACTATTGTCTTGCTC

TCGGGTTGCTACAACCTATGTAGGTTGCGATTAGACGACGAGCCTCAAGATTTGCGCTTTG TTGACATGCAATGCAACTAGCTGTATTACTTTAAAACTTTACCTATGTGAAAAATAATCCG TGATCAAGGAAGGCAAAAAAACTCTTT >'000203a-070.scf came from CONTIG 60 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-070.scf'(19>728) CTACGGCATCCCCCGGGCTGCAGGTCGAGTTTTTTTTTTTTTTT^^ TTACATTTTAGTGCTTTCTTAAAATAAATATAATAATATAATTATCAAACATACAGTGAGA AGTAAAGCACACGTGTGAACGGCATGTCACAGGAGTTCACTCAGGACTGTTTCAACACTC AGCACTGGAGAAACCGCACAGGCCTACCTATGTACAGACGACCCAACCGCCAGGGCGAG

GCCACCGCGTCCCCTCCGTCCTCATGGACACGGCCACTCCCCCTTGCGTTGAAATGACCAG TTTGCATGTTTTAACTTTTCTCTCCGTO

AAAAATTCAAGTAACACTCCCAAGAAAAAAAAAGTGCAAACTAATAAGGGACTCAGAGT CCGGCGCCGGTCAGGGGCAGCGCACAGCGGGGGGGCAGCCGGCCGAGTCTGTCCCGGAA CACGGGGCGCAGGACCCCGCCCACTCGAGGAGGGGGGGACGGAGGCCGGCCTGGGTCCA

AAGCGCCAGACCTTTGTTGAAAGCAGCACAGCCCGCGAACGAACGCAGTCCGCGGCCGAC TTCGGACCAAGGAAGGAGAGGGGGAAAAATAAAAGTATTAGGATCCTTTTATAAAATATA AAATTTTCAAATTTTATAAAGGGCGCCCCCGGGGGGGGGGGCCCC >'000203a-071.scf came from CONTIG 61 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-071.scf'(38>713)

TTGACATCCTCCATTTCGCTGTGCTGAGTTAGTACAGGGAAGACGGGGAAGTGAAATGCC AACAGTAGTAGATGGGGGACTTCCCTGGTAGTCCAGTTGTTGAGACTTCGCCTTCCAGTGC TGGGGGGTGCAGGTTCAGTCCCTGATGTGGGAGCTAAGATCCCTCATACCTCATGGCCAA AAAACCAGAATGTAAACAACAGATACAATATTGTAACATATTCAATAAAGAATTAAAAAA

AAATTTTTTTATAAAATATACTTAAAAAAAAACCTGACAGTTTCACAGAGAGGGCTGTGA TAGGATTGCTCATGAGGAAATCCAAGGAATAGAAGTTTTTGATAGAGGATGATGGGAAGT GTGTTAGCAGAAGTAGGACTGCCTACTGTCCATCTGGACCATGNAAAGCACANATTCATC CCGCACAGCTTGGAGAGAATGTCTCACTAAGAGCTCATGCCTTGTATTCCTCCCACATTAT TTGTATTGTTGGTTTTATATACGTTTTTTTGCTGATATTACCATATTAGGTπ

TGTAGGACATTCTATGTAGAGAAAGATAAACTTAAAAAAGAAGCCCTTTTTCTTTTTTTTN TTAAATAATGCATCTTAAGTGAGTCACCCTTTCGGCAAAAAAGAGAACACTTTACTTATTA CTATTTCTT >'000203a-072.scf came from CONTIG 62 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-072.scf'(38>334)

CTGGTGCTTTCGGCCTCGCTGCGGTGCCGACAGTCCGTTCATGCCTCGCGTTTGAGGGCAG GGGGTGGCTCAGCGGCTGGCTCGCAGCTTTCTCCGCTGGCTGAGGCCCGCCACAGCCGAC ATGGGCTGTTTCTGCGCGGTTCCGGAAGAATTCTATTGCGAAGATTTGCTTCTGAATGAAT CCAAGTTAACTCTCACCACCCANCAAACAGGCATCAGAAAATCACGAAAGGGCTCATTGT

CCTTGAGCACCGTATCCGCCACTCAACCCTGGGGAGGTGAGTATTTTTGGCTTGC

>'000203a-073.scf came from CONTIG 63 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-073.scf'(l>639) CGGGGCGCCCTCTAAACTATGGATCCCCGGGCTGCAGGCCCAGTTTCCCTCCCAGAACATT

CTTGGGACCAGCCACCTTTCCCCAGGTGTGTGCTGCCCACTGCCACCCAGAGGTGGGATG GCAGGTTCCAGGTTCCCTCTTGGATCCCAGGCTTCCCCTGACATCAGCACCATTCAGTGGT TTTCCTGGCTCCATCGCTATCGCTTCATGCTGAATGGACAGGACTGTTGACCTGTCTCAAG AAGCCCATAAGATTTGAGCAGAAACGNTGACTTCCTTGTACCTCTGCCAGAGCAGCTCCCT TCTCCCCCCCAGAATTTCACCAGATCTCTTCATGCTGCTCTTNATTTNCGTACTTGAAGTGG

NTCTGCCGACAAACAGCAGACTTTGTGTGTCCCACTCTGACTTGCAGGACGGNAGNTTCTT TCTCTTAAGTTGATCGCTTCTTGCTGTGACTGNCCCGCTGGNGAAAATGGTTTTGCCTCGTT TTAAGTGAACAGGAGACTAGATGCTGTACTAAACAGATGGAACCGAGAGAAACACTACC ATCAGTAAAGACCACCACCCAACACTCATAAACGCTAACAAATCTGCTGAAAGATGTAGC TGGAAAAAAAAAACGGGGGCCGGCCACCTTA

>'000203a-074.scf came from CONTIG 64 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-074.scf'(l>580)

GCGGGCGCGCTCTAAACATGGATCCCCGGGCTGCAGGTTCCTGTGTCGTCTTGGAGGTGA CTCGGCGTGATTGAATTTGCGGCATCTTCGCATTCACTCACAGGTCAAAATGCAGATCTTC GTGAAAACCCTGACCGGCAAGACCATCACCCTGGAGGTGGAGCCCAGTGACACCATCGAG AACGTGAAGGCCAAGAATCCAGATAAGGAAGGCATTCCCCCTGACCAGCAGAGGCTCATC TTTGCCGGCAAGCAGCTGGAAGATGGCCGCACTCTNTCTGATTACAACATNCAAAAGAGT

CGACCCTGCACCTGGNCCTNCGTCTGAGGGGGGNATGCANAATTTCGGAAACCCNNTGAC GCAGACATCACCTGGAAGGGAGCCCANGACACCACGANAACGGAAGCCNAAATCAGATA GAGGCATNNCCCCGACACAAGCTCATCTTGCGCAGCACTGGAGAGGCGCCTCTTTGATAC ACANCAAAAGGCGACTGCCCGGCCTCGCGAGGGGGAGCAATCTCGAAACCGACGCAGAC ATACTGAGGGGGCAGCACACCAAAGAAGCAAACAAAAAAGA

>'000203a-076.scf came from CONTIG 65 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-076.scf'(45>598)

GCACGAGGCCTTCATCCAGCACCTTCCCCTGAGTGAGCGCATCCGGGGCACCGTCGGACC AAAGAGCAAGGCAGAGTGTGAGATTCTAATGATGGTGGGCCTGCCCGCTGCTGGCAAAAC

CACGTGGGCCATCAAACATGCAGCCTCCAACCCCTCCAAGAAGTACAACATCCTGNGTAC CAATGCCATCATGGATAAGATGCGGGTAATGGGCCTACGCCGTCAGCGAAACTACGCCGG CCGCTGGGACGTCCTGATCCCAGCAGCCACTCAGTGCCTCAACCGTCTCATCCAGATTGCT GCCCGCAAGAAGCGCAACTATATCCTANATCAGACAAATGTTTATGGGTCAGCCCAGAGA CGAAAAATGAGACCATTTGAAGGCTTTCAGCGCAAAGTATTGTATTTGTNCCNACTGATG

AGACTGNAAGACGAACAATAAGCGACTGACGAGAAGGAAGGAGTCCNANACACGCGTCT TAAAATGAAAGCACTTCACGTGCCGATGTGGGACTTCTGGAGAGNGCTGTCATGAGCTGC AGGAAAGGAGCGAC >'000203a-077.scf came from CONTIG 66 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-077.scf'(46>306)

CACGAGGGGAATCTTGTCCTTCCAGGTCCGCCAGTTTAAGCGCCTTTATGAACATATTAAA AATGACAAGTACCTTGTGGGCCAGCGCCTCGTGAACTATGAACGGAAATCCGGCAAACAA GGCACATCACCACCACCTCCACAGTCGTCCCAAGAATAAAGTGGTTGTCTCCACTACCTTG GCCTTCCCCTTGCCTTCACGTGTCCTTTTTTGTGGACTTCTCTCTCTGGAGATTTCCCCAGT

GATCTCTCAGCGTTGTT

>'000203a-078.scf came from CONTIG 67 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-078.scf'(39>281) CTAGTCTGAGTTTTTTTTTTTTTTTTTTT^^

GTGGGTTTTTGAGAATGAATGTGCAGAGTTTATGATGTGTGTCAAGCATGCCTCGATAGCC ACAGGCTTTACAAAAATTACCTATTGTTTGCTTCTTTGGATTGACATGCAAATCTGTTTCAT GATTCTCACACTCACGACAGAAAACAAATTTΓTTTATGAATCCATCCACCATGCTT >'000203a-079.scf came from CONTIG 68 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-079.scf'(16>24) ACAGGGATC

>'000203a-080.scf came from CONTIG 69 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-080.scf'(38>623)

NAATTCGGCACGAGGCAAGCGCCTGCTGGAGCCCCCGTGCTCCTTGCACTTGAACTCTATG GGGTTTGGTGGGCAGAGGCTCAGGAGTCCCCTGGATTTCCCCAGCTGGTATCCTGGGACG TGGTAAGCCTTGGGGCTGGGGTAGCATGGGATCCCCCGAGGACCCANATTCTGGTACTNA GGGCAAGGNGAGGNGAACCCGNACCTCANCCGTCCCCCAGTCTACAGCCTGAGCCCAGTG TGCTCCCAGCTCCCCANTCCNCATGAAGCCTGCCGGNGGCTGGCAGNAGGGNTTAGAGGN

NCTGGCCTTCGATTCCTTTTCTGTCGCGCTGCTTTCACCCGCTTCCTGCAGCTTTGCTCTGG CCTGATGATCGTGCTTTGTTCTCTGTACTGTTAACTGAGCATGCCACATTTGTTGAAATGTT GTTCAAGTGTAAGCAAGGAGAGGTCCAATTGTGATGGGGATGGAGGCATGGACTCTGCTT CTATCCTTCTACTTATCTGAAATGTTGCTTCTGCTGTTGGATTATTATACAGGGCAACCTAT ACAGCGAAAAAAAAAGGCAAAAAATTCTCTACCACGAGA

>'000203a-081.scf came from CONTIG 70 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-081.scf (41>563)

CTCCAGTTACCTCTGCCAGTACCGCTGTGTCAACGAGCCGGGCCGCTTCTCCTGCCACTGT CCACAGGGCTATCAGCTGCTGGCCACGCGCCTGTGCCAAGACATTGACGAGTGTGAGTCG GGTGCGCACCAGTGCTCTGAGGCCCAGACTTGTGTCAACTTCCACGGNGGCTACCGCTGT GTGGACACCAACCGCTGTGTGGAGCCTTACGTCCNAGTGTCCGACAATCGCTGTCTCTGTC CGGCCTCAACCCCCTGTGCCGGGAGCAGCCCTCATCATCGTGCACCGTATATGAGCATCAC

CTCGAGCGGAGCGTACCGCGGACGTNGTTNCAATCAANCANCNNTCGTCTACCTGTGCTA CATGCTTTCAATCGTGCTGTAACTCGCAGGAACTCTACATAGCAATCACATGCACGCTGCT GTCTCGCTCGGCTGGACGGCCCCGGATACGGCTGACTGAGAGTCACTTACTCTCTGATACG ^ GCACTCTTTTGAATACGCTTGGGGCTACTTTGGGGGGG

>'000203a-082.scf came from CONTIG 71 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-082.scf(48>533)

GCACGAGGGCCTGCTGCAGCCCGGCTGCCAGCTGGAGTCCCTGTGGGTGAAGTCCTGCGG GTTTACGGCCGCCTGCTGCCAGCACTTCAGCTCTATGCTGACCCAGAACAAGCATCTCTTG GAGCTGCAGCTGAGCAGCAACCCGCTGGGCGACGCGGGCGTCCACGTGCTGTGCCAGGCC

CTGGGGCCAGCCGGCACTGTGCTGCGGGTGCTCTGGGTGGGCGACTGTGAGCTGACGAAC AGCAGCTGTGGCGGCCTGGCCCTCACTCTGCTGGCCCAGCCCCACCTGCGGNAGCTGGAC CTGANNCATACGGNCTGGGCGACCCCCGCGTCTGCAGCTGCTGGGGCAGCTGGAGCACCC GCTGCAGCTGGAGCACTGTCCTGTCGACTCTATGGACCGAGCATGGACGACGCTGCGGCT GTGGAGAAAGCAGCTGGNCTGCGATCTTTCTGACCCGTCCCCAGNGCGTNATGAAAAGTN

CATCA

>'000203a-084.scf came from CONTIG 72 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-084.scf'(47>388) GCACGAGGCACAGTAGCATCACTTCAGAAAGGAGCCAGACTTATTCTCAAAGAACTATGT

TCACACTTTTCAGCAGAAATAGCGATGGTTGTAACATATGTATCCCCTCCCTCGGATTTGA AGGCACAATCTACAGTGTTTCTTCGCTTCTTTTCTGATCTGGGGCATGAAAAACCAAGATT GAGATTTGAACTATGAGTCTCCTGCATGGCAACATAATGTGTGTCACCGTCAGGCCAAAC AGCCAGCCCTGAACGGTGGNTTTATTACTTGTGTATTTGTGTTGGATGATAAACACTCATC ATCTCTCCTGTAGTCCCTGCTCATTTCACTTAACCCTAN

>'000203a-085.scf came from CONTIG 73 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-085.scf(9>658)

CGCTCTATACTAGGGATCCCCGGGCTGCAGAATTGGCACGAGGGGAGCTCCGCATCCACA CCGGCCAGCCCAGATCCCGAGGTCTGACAGCGCCCGGCCCAGATCCACAAGCCTGCCAGG

AGCCAGCCGAGAGCCAGCCGGCCGCGCGCTCCTACCCCAGCAGTCTCTGTCCTTCGGCCT GAGCCCCGCGTCCTTCCCGGGACCTCTGCCCCTCGGGCAGTGCTGCCACCCTGCCGGCCAT GGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGNGCGCAGGCCAGCTCCACCCCGCT GCCACCCACCCGCATCACCCGGCTGCAGGAGAAGAAGACCTACAGGAGCTCAATGACCG NCTGGCTGTCTACATCGACCGTGTGCGGGCGCTGGAAACGAAATGCAGTCTGCGCCTCGC

ACACTGATCTGAGAGGGGGCAGCCGGAGGGTCTGGCTTAAGCCCGCTCCAGCCGACTGGG GAGCCGCCAGACCTGACCGTGGNCAGACGCGCCGCGCGCGGACGACAAGGGAAGAGTCA GGACCAGCACGCATCAAAGAGGAACGAGGCCCAGCCGCTAGACGAGGCGTCACCAGAGC GGCGGCTGTTAGAAGCCGGGGGACGGACGGGGAGGCATGGGCCCGGGGCAAC

>'000203a-086.scf came from CONTIG 74 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-086.scf(48>633)

GCACGAGGATGAATTTTCACTGGCCCTTCGGCATCTGGTTGTGCAAAGCCAATTCCTTCAT TGCCCAGTTGAACATGTTTGCCAGTGTCTTCTTCCTGATGGTGATAAGCCTGGACCGCTAT ATCTACTTGATCCACCCGGTCTTATCTCATCGGTACCGTACCCTCAGGAACTCTCTGATTGT

TATTATAGTTGTTΓGGCTTTTGGCTTCACTAATGGGTGGGCCAGCTCTGTACTTCCGGGAC ACTCTGGAGTTGAATAACCACACTCTTTGCTATAACAACTTCCATGAGCATGATGTGGACC TCAGGTTGNTGAGGCATCATGTTCTGACCTGGGAGAAAGTTATTGTTGGGTACCCTCTCCC TCTGCTAACAAGAGCATTTGCTACTTGGCCTCATCTCAAGAGAAGAACGAGCACCTGTACT CAGAAGCCTCCTGACCACCCGGCGNGGNCATGCCTTNCGATTGCTGAATCCTATCACTGTT

ACATTGGAACCACGACCACACATACTATTCACCAAGCTACAGCACACCCCTTCACGCCGN

GTTCTCAAATGCTGACCCCCCTTACCCGATATAAAAG >'000203a-087.scf came from CONTIG 75 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-087.scf(46>645)

GCACGAGGATTTAATATTGTGGAGGGTGGGGCTTCCAGGTGAATACAGTTGCTGGTTGCT GAGCCATGCCCAACTCTTTGCAACCCCATGGACTGCAGACCGCCAGGCTCCTCTGTCCATG GAATTGTCCAGGCAAGAATACTAGAGTGTGTTGCCACTCTCTTCTCCAGGGTATCTTCCGA ATATAGGGATCAAACCTGGATCCCCTGGATTGCAGGCAGATTCTTTATCCTCTGAGCCACC

AGGGAAGCTCCTAGTCACCCTAAAACCTCCAAATTCTTAAAAAAATTACCCTATCTACTTC CACCCCAGTCTTTCTCTCTTCTTCTTTTGGTGTCTTGATTTTTGCTTTTGGCTCT^ ATCACATCACCTCTTCCAGCCTGACTATGAGTCGCCTCAGACTCAGAGCAGTTCACTCACG AATCTTGGCTTGACCACATACTCTCGNACTTGGCTCTGACTGCTTTTTTTATTGTTATTCGA CATCTCCACCCGCGAGATCTCTTTGGACAGCCTTGTATAACATCTGTTATACCTTTTGTACG

CTATTTGGGAAAAATAATTAAAAGGGGCTCCCCCAAAAAATTACGCAA

>'000203a-088.scf came from CONTIG 76 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-088.scf(19>21) TAT

>'000203a-089.scf came from CONTIG 77 at offset

0;"E:\SEQUENCE\export EST_db\000203a\000203a-089.scf(l>428)

AGGTGGCGGCGCTCTTATTATGGATCCCCCGGGCTGCAGAATTCGCACGAGGGAGGCCTT TCGGCCGCAGCCATGGCGCCCAGCCGGAATGGCATGATCCTGAAGCCCCACTTCCACAAG GACTGGCAGCGGCGCGTGGCCACGTGGTTCAACCAGCCGGCTCGCAAGATCCGTAGACGC AAGGCCCGGCAGGCCAAGGCGCGCCGCATTGCCCCACGCCCCGCGTCCGGTCCTCTCCGG CCGGTGGTGAGATGCCCGACGGGTCAGTACCACACGAAGGTTCGTGCCGGCAGGGGCTTC AGCCTGGAGGAGCTAAGGGTGGCCGGCATCCACAAGAAGGTGCCCGGACCATTGNNGAT CTCGTGGACCCGNAGCGCGGANCAAGTGCACGGAGTCCCTGCAGGCCACGTGCAGCGCTC

AAGGAGTAN

>'000203a-090.scf came from CONTIG 78 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-090.scf(42>591) NAATTCGGCACGAGGGGAAGTGTATAATTTCCTGGCCACTGCAGGTGCCAAGTACGGCGT

GGGCTTCTGGAGGCCTGGCTCTGGAATCATTCACCAGATCATTCTGGAAAACTATGCGTAC CCTGGGGTTCTTCTGATTGGCACTGATTCCCACACCCCTAATGGCGGTGGCCTGAGAGGCA TCTGCATTGTAGTCGGAGGTGCTGATGCCGGGNACGTCATGACTGGGATCCCCTGGGAGT TGAAAGGGCCCCAGGTGATTGGGCGTGAAGCTGACAGGCTCCCTCTCTGGCTGGACCTCA CCTAAGATGTGATCCTGAAGGTGCGGGTATCCTCACAGTGAAAGGTGGCACGGGCGCCAT

CGGGNAGTACCACGGGCCTGGAGTAACTCCATCTCTGCCCCGCATGCGACCTCTGCACAT GGTGCAGAATCGGCCACACTTGTGTTCCCTACACACAGAGAANAATACTGACAGACGGCG GCAATATGCACCTGTGAGATTAAGATACTGTACTGCTTGCTGCCTTTACAATTATATTACC TAGGCGA

>'000203a-091.scf came from CONTIG 79 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-091.scf(41>338)

TAATTCGGCACGAGGCCCCTTTCATCACCAACCCTGGGTATGACACTGGAAACGGTATTCA TCTTCCCGGCACTTCTGGGCAGCAGCCCAGTCTTGGGCAACAAATGATCTTTGAGGAACAT GGTTTTAGGCGAACCACACCGCCCACCACGGCCACCCNCGTAAGGCATAAGCCAAGACCG

TATCCGCCGAATGTAAATGAGGAGATCCAAATTGTTCATGTCCCCAGAGGAGACGTAGAC CATCATCTCTACCCTCACGTTGTGGGACTCAATCCAAATGCTTCTACAGGCCAAGA

>'000203a-092.scf came from CONTIG 80 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-092.scf(47>391)

GCACGAGGCAGCCCGAGGACAGCCAGCAGGACCTGCCTGGGGAGCGCCACGCCCTCCTG GAGGAAGAGAACCGGGTGTGGCACCTGGTGCGGCCCACGGACGAGGTGGACGAAGGCAA GTCCAAGTGCGGCAGCGTGAAGGAGAAGGAGCGTACCAAGGCCATCACCGAGATCTACC TGACCCGCCTGCTGTCCGTCAAGGGCACGCTGCAGCAGTTCGTGGACAACTTCTTTCANNA GCGTGCTGCGCCCGGGAAACGCGTGCCACCGGGCGTCAAGTACTTCTTCGATTTTNCTGNA CGAGCAGCAGAAAAGCATGACATTANAGATGNANGACACCNATTNC

>'000203a-093.scf came from CONTIG 81 at offset 0;"E:\SEQUENCE\exportEST_db\000203a\000203a-093.scf(44>356)

CAAAAACCAGAAGTGACGGGAGGTGCTGCGCTCCCCTGCGTCGTGGCAAAGTCAGCTGGC CTCTTGTGTGTGCGTGTGTGCGTGTGAGGAGCCGAGTGTGGGTGTGTGGCGGGCGTGGGA GCAGCTTTCTCACATAGTGCCTTATACACGCTCTAAAGAAACCAGTCTTACATGTTAAGAA CAACCAGTGTTACATTTTCTACACTACCTTNCATTTCAGTAGCTTTGATGACCAGTTTTGCA GTTCATGGAGGAAATCATGGNNGCGTCCCAAGGGGCTCCCCATGCCCGAGAGCCGACTGG

TCNTGTGACG

>'000203a-094.scf came from CONTIG 82 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-094.scf(40>373)

CCAGCCACAAGTGTCTTCAAAAATTAACAAAACAAAAAAAATATATATATGGCCATAGTT CACAGTTAAGCAGCCAAAAGCTGCTCCAATTATAGCCTTTAAACAACATGTGAGCATCCT CCCTTTCCCTCCCCTTCAGTAAGTATATTCACAGCTTCAAGTCCTCTGTCCGAAGCACTCTC CACAGAGAGAAGTTAAGAGTCAATGCACCTTTCTGCAAAATTGTCTGAAAAGCTTTANNA AACAGTACGTCAAGGAAACTGCTTCGGNTC

>'000203a-095.scf came from CONTIG 83 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-095.scf(42>489)

CGACAGCCTAGAGGGCTTCGTGCTGTGTCACTCCATCGCTGGGGGAACAGGCTCTGGCCT GGGCTCCTACCTCTTAGAACGGCTCAACGACAGGTACCCCAAGAAGCTGGTGCAGACATA

CTCAGTGTTTCCCAACCAGGATGAGATGAGCGATGTGGTGGTCCAGCCCTACAACTCACT GCTCACGCTCTAGAGGCTGACCCANAACGCCGACTGTGTGGTGGTGCTGGACAACACTGC CCTGAACCGGATCGCCACAGACCGCCTGCACATCCAGAATCCCTCATTCTCCCANATCAAC CAGCTGGTGTCCACCATCATGTCAGCCAGCACCACACCCTGCGCTACCCCGGCTACATGA AACACGACCTCATCGGCCTCATCGCCTCGCTTATTCCACGCCACGCTNCACTTNCTCTGAC

TGTTTCACCCCCTCCACAGNACAGCG

>'000203a-096.scf came from CONTIG 84 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-096.scf(43>460) CATCAGGCTCGAGGGCTCTGTTGTGCGGACTGCTCCCCCTGGACCCTCTGGTTTCTCTGGG

CCCTCTGACCTCTTTGATCCTGCTGGTAAAGAAGGGCTTCGTGGGCCTCGTGGGGACCAAG GTCCAGTTGGTCGAAGTGGAGAGACAGGTGCCTCTGGCCCTCCTGGCTTTGTTGGTGAGA AGGGTCCCTCTGGAGAGCCTGGTACTGCTGGGCCCTCTGGGACCCCAGCCCACAAGGCCT TTTTGTNGCTCCTGTTTTTCTGGGTCTCCCAGCTCTACAGTGAGCGCGACTACACGTGTCGT GATCTGTGGAGGGGTTGACACCTCTTTTCCTCGTTACATATAAAAATGTAAACCTGCCTTA

ACTGGACATATGACCTGATACTCACTTATATΓTTTTCTGGCTTTCTTAACAAA

>'000203a-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-001.scf(45>465) GCACGAGGCTGTTTTATATTCGCCCATTCCAGTCCATTTTAATTCTCTGATTCCTAATATGT

TGATGTTCACTCTTGCCATCTCCTGTTTGACCACTTTCAATTTGCCTTGATTCATGGACCTA ACATTCCAGGTTCCTGTGCAATATTGCTCTTTTTATCATCAAACTTTACTTCTATCACTAAT TACATCCATAACTGGGTGGTGTTTTTTGCTTTGTTTTCATTCTCTTCTTCTTTTTGGAGTAπ TTTCCACTGATCTTCATTAACATATGGGGCACCTACCGACCTGGGGGGGTGATCTTTTCAT GTCTTTCTTTTTGCTTTTTATTCTGTTATGGGGTTTCAAGCAAGATATGAAGAGT^

CCTTTTCCGGGACACGTTTGTCAGATCACACAGACTGCCGCTGGGGTTG

TTTTTTCAGCTTAATACTGTATGTCTCGTAAGATGGGCCTTATTGCCTGTATTCTTTGATAT GTGATTAAGCCTATAGCTTTCAGTGACCAAACATTTTACAGAGTAAAAAATGTTAGGAAG CAGAAAAAGAAAATCTGATTTATTCTATGTCTCATTTATCCAGCCCTGCACTTAGATAGAA GTGTGC >'000203a-003.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-003.scf(40>551)

TTTTGACAGAGAACATTTTTCTCACATACACTTTCAGAGTCAAAGCTGTGGATGGGGGAGA TCCCCCCAGATCTGCAACAGCCACGGTCTCTCTCTTTGTGATGGATGAGAATGACAATGCT

CCCACTGTCACCCTTCCCAGAAATATTTCCTACACTTTACTGCCACCTTCGAGTAACGTCA GGACAGTAGTAGCTACGGGGTTGGCAACAGACAGTGATGATGGCATCAATGCAGACCTTA ACTACAGCNATGGGGGAGGGAATTCCTTCAAGCTGΠTGAGATTGATTCACCAGTGGGNG GGTTTTCTTAAAGGAAACTCACCCAAAGCATTATGGCTTGCACAGGNTGGTGTGCCAGNG ATGACAGGGGCAGCTTCCCATCTACACGATCTGTGCTGTGTTGTCATGAAAGGTTCTAAGC

ACTGGATGACTCCCAAAGCAAAACTGCCNCCCCATCACCAGAATATACGGGACCAGCTAT AATTACACAAAATAATGTTTGGGGGGGG

>'000203a-004.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-004.scf(43>365)

GCACGAGGGCCCTTTGACGTTCCGGCCGCGCGCCCCGCGCCTCGTCGCTATGCCTCGCAAA ATTGAGGAAATCAAGGACTTTCTGCTCACAGCCCGCCGCAAGGACGCCAAGTCCGTCAAG ATCAAGAAAAATAAGGATAATGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACC TTGGTCATCACAGACAAAGAGAAGGCAGAGAAGCTGAAGCAGTCCCTGCCCCCCGGTTNG

ATTCTCAAAAAAAAAAAAAAAA

>O00203a-005.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-005.scf(45>563) GCACGAGGCCAAGAATACAGTCACCTGCAGCCGGGGGACCACCTGACTGACATCACCTTA

AAGGTGGCAGGTAGGATCCATGCCAAAAGAGCTTCTGGAGGAAAGCTCATCTTCTATGAC CTTCGAGGAGAGGGGGTCAAGNTGCAAGTCATGGCCAATTCCACGAATTACAAATCTGAA GAAGAATTTATTCGTATTAACAACAAACTGCGCCGNNGAGACATAATTGGAGTCCCAGGC ANTCCCTGGAAAACCAANAAGGNCGAGCNTAGCGTCATCCCCTATGAAATCACACTGCTG TCTCCTTGCCTGCACATGTTACCTCATCTTCACTTTCGCCTCAAAGACAAGGAACACCGTA

TCGTCAGAGATACTTGGACTTGATTCTGATGACTTGTGAGCAGAAGTTTATCTCCGCTCTN ATAATCACGTTTTATNAAGTTCTTGNTGAATGGNNATTCTAAAATGTAACTCCATGAGAAC ATCATCCAGGGNAGCTGTGCTAGCTTTACACTACAA >'000203a-006.scf came from CONTIG 6 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-006.scf(47>562)

>'000203a-007.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-007.scf(32>465) GCCTTTTCTTCCACTTTATTTCATATTCCCACCACAATAATGACTCCTTTAATTTAAACTAA

TCCATGGCT

>'000203a-008.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-008.scf(39>747) CAAAATGTCTTGAAATGATATTACCATAATTTTAAGTAGGAAAGTTACCTGAACACTTCTG CTTCCACTTAACTGACTGGCCCGCAATATTGTAGGAACAGCATGTCCTTTGTACTGTGGTA TTCAGAACAGCCACAGCACTCACTTTTTCCAAATGATTCTAGTAATTGCCTAGAAATATCT TTTTCTTACCTGTTATTTATTAATTTTTCCCCATATTTTTATATGGAAAAAAAAAπ^ GAAGATACTTAGTATGCAGTTGATAAGAGGAATCTGTTCTAATTATGTTTGGTGGATTATT

TTTATACTGTATGTGCCAAAGCTTTACTACTGTGGAAAGACAACTGTTTAATAAAGAATTA CTTCCCAAAAAAAAAAAAAAAAAAAAAAAATAACCGGAGGGGGGCCCGGTCCCCATCGT CCTATGGGAGCGTTACCATCCACGGGCGGCGCTTACAGCNCGGACGGGAACCCGCCGTCC CCACCTACGCCTGCACCCACCCCCTTCCCGTGGGTAAAGGAAAACCCCACCACGCCTCCA CGTGCGCACCGAGGCGAGGAAAGAAGGGTAATTTGTAATCGTAATTTTTATATATTTTTAC

ATGCCAAGCCATCCTTAAAAAAAAAAGAAGGGGGGGGTGTGTAAAAACTCTTAAAGCCC CCGAGAAAAACCTAGGGCCCCCCCCCCCCTCTTTGGGGGCGAC

>'000203a-009.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-009.scf(37>606)

TAATTCGGCACGAGGCTCATTTTTCCATCTCTTATGAGGACACACATCACTGAATTTAGGT TCTACCCTAAGTCCAGAATAATCTCATCTTGAGATCCTGAAACTTATCACATTTGCAAAAT TCAAGAGCCAGGGAAAGCTGAGCAGTGACTGCTAATGGAACAGGGTTTGCTTCGAGGGTG ATGAGAGTGTTCAGGGGTAGACAGGGATGCTGTTTGTACGACTCAGTGAATATACTAAAA CCCNAGGGATTGCATGCTTTAAAGAAGAAGCTTAATGTTTGTGAAATTAGTCTCAATATAG

CTGTTATTTTTAAAAGAGCCTGGCTCGGGGAGCCATCAATCATACTGCTATTTTTATATCG ATGTGCCAGCAGAAGTATTCTTAAATCTTTATGACACTGTTTTACTTTTGGCTGTCTCCCAC CTGGTTTAAATACATTGAACAGAACCCAGNGAAAGCCTATGGTACAGGGAGAGCCCCGCT TTGCCATGAGGGATAGAATTGGTGATGCCAGAGATTCCAAGAATTTGTGAAAAACCAGAC TCCGGGGCCGGGTAACCTTCTCCG

>'000203a-010.scf came from CONTIG 10 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-010.scf(44>427)

GCACGAGGAGAGAACTAGTCTCGAGTTTTTTTTTTTTTTTTTTAACT^ TACAATGCTGTGTTGGTTTCTGTCATACCAACGTGAATCAATCATAATTATATTATATATCC

TGATGGCACATGTTAAGAATGCATTTTCTCGTTTGAACATTACTGAGTTGGGAGATATGCA GGTTATGGATTAGTCTCTCTTGTGACTACTGACTTAACTAAAATTCAGAAGATACAGCCAT TTACCTACAGTCCTCCAGTTAAAACATGGCAGACCTGAGCCTANAACCCAGTTTGCTCATT TTCACTCCAGTATCACCCAACTATACCTAAAATGTTCCCTCTGCAGATACTATTCAAAGCA CTTTATTTATTTCTAT

>'000203a-011.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-011.scf (31>278)

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-012.scf(l>719)

CAACCCTGCCCGACTCGAAAACAACACCAACGAACCCAAAACAAAAGGAAAATCACAGC TGAAAATTTTCTGCTTTCTTAATATTTATTTACACAACTACAACAAAGACACTCAAAAAAA AACAGGACGCCCCCCCTAGGCATAATATCGGTTACGGAGGACCGCCCCCTCCTCCC >'000203a-013.scf came from CONTIG 13 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-013.scf(284>351) ATGAAGCGTTATATTTTGTTAAATTCCGTTATATT^ AAGCGC

>'000203a-015.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-015.scf(l>680)

CTGCGGCCCTCTACACTATGGATCCCCGGGCTGCAGGCGGAAGATGGCGGCCACGGCGGT GAACGGGGTGGCCGGCACCTCGAGCTCGGGGTCTGCGGCGGCCTCGGGCGCGATCCTGCA GGCCGCGGCCGGCATGTACGAGCAGCTCAAGGGCGAGTGGAACCGGAAAAGCCCTAATC

TTATCAAGTGCGGNGGAAGAGCTGGGCCGTCTCAAGCTGGTTTTGTTGGAGCTCAACTTCC TGCCAACNNCACAGGACCCAAATGACCAAGCAGCAGCTCATTCTGGCCCGTGACATACTG GAGATCCGGGCTCATTGGAGTATCCTACGCAAGGACATCCCCTCCTCGAGCGGGACATGG CCCAGCTCAAGTGCTACTACTTCGATTACAAGGAGCAGCTCCCAGAGTCAGCCTACATGC ACCACTCCTGGGCCTCACCTCCTCTTCTGCTGTCCCAAACCGNTGGCTGATTCCACCAGAC

TGGACGGTGCCTGCCAAGACATCCAACCACGGTACACAAGCATCGGGNCCTCGAGCATAC GAGGAGGCAGTACATAGTATTCTGGCAAGCACATCCCGCGAACTACCTTCTCATGATTCG CTGAACTCAGAAGAAGTTGTGANGAAGGCATGAAATCTTTACAAGCCCGACCCCCTCACA ACCAAAAAAAAAAACCAAA

>'000203a-016.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-016.scf(8>560)

GCTCTATACTATGGATCCCCGGGCTGCAGGTTCGCTTAGGCGCAGACGGGCAAACAGAGC CAGCATGCCGGTCGCCCGGAGCTGGGTTTGTCGCAAAACCTATGTGACCCCGCGGAGACC CTTCGAGAAGTCCCGCCTCGACCAAGAGCTGAAGCTGATCGGCGAGTATGGGCTCCGGGA

CAAACGTGAGGTCTGGAGGGTCAAATTCACCCTGGCCAAGATCCGAAAGGCTGNCCGGGA GCTGCTGACGCTGGATGAGAAAGACCCGCGCGTCTGTTCGAAGTAATGCCCTGTGCGGCG GCTCGTCCGTATCGGGTGCTGGATGAGGCAAGATGAAGCTGGATACATCCTGGGCTGAAG ATGAAGATTTTTTGAGAGACGCCTGCAGACCAGTCTTCAGCTGGGCTGCCCAGCCATCACC AGCCCGGGCTCTCCGCACGCACACAGGTCGCAGCAGGGAGACATCCGTCTCATGGCGCTG

GACTCCAAACCATCACTCTCCTCCTCCCCTCGCGGGGCGNCCGGCCGGGAAGAANAAGCA AAGACAGGGGGT

>'000203a-017.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-017.scf (44>531)

>'000203a-018.scf came from CONTIG 17 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-018.scf(13>586)

TGCCATCAGCCGGACTCAAGTCTGCTCTCGGCTGCAGCGAGGCACATGCTGGTGGGACTG CACACCAACGCGTGAGGCATNCAGGCACCGA >'000203a-019.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-019.scf(13>287)

AAATATGGATCCCCCGGCTGCAGNAATTCGGCACGAGGCAGGCCTTTTTTTTCTCTCTCAG ACAACCATCTCATGGACCCCATTCCAGGAAAGCTCTGAGTATATCATTTCATGTCATCCAG TTGGCATTGATGAAGAACCCTTACAGTTCCGAGTTCCTGGAACCTCTGCTAGTGCCACCTT

GACGGGCCTCACCAGAAGGGCCACCTACAACATCATATGGNAAGCAGTAAAAAAACAAN CAGAGCAGAAAGTTCGCGAGGAGGGGGTTNCCG

>'000203a-020.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-020.scf(2>215)

CTTCCGTTATACTAAGGATCCCGGCCGCGGAATTCGGCACGAGCCTCAGTTTTTTTTTTCA

GCCTCAGGCCCACCCTGAGGGTTCTCCTCCAAGCTGGCATCGCCCCACTTTACAGATGACC

ACCCCAGGCTTGGACAGGGCCGCCCCTGGACAAGAAGCTGATCAAGGCCCTCTTTGACGT

GCTGGCGCACCCCCAGAACTACTTCAAGTACA

>'000203a-021.scf came from CONTIG 20 at offset

0; "E:\SEQUENCE\export EST_db\000203a\000203a-021.scf (29>265)

CCTGCAGAATTCGCACGAGGAGAATCTATTTTTTCTCTTGATGAGGGTGAAAGAGGAAAG

TGAATAAGCTGGCTTAAGACTCAACATTCAAAAAACTAACATCGTGGCATCTGGTCCCAT CACTTCATGGCAAATAGATAAGGAAAAAGTAGAACGGGGTCAGGCTTAATTTTTTTTGGC

TCCAAAATCACTGCAGATGGGGGTTGCAGCCATGAAATTAGAGATGCTTGCTTCTTG

>'000203a-022.scf came from CONTIG 21 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-022.scf(36>646) AATTCGCACGAGGTGGAAGCTTTTTTGTCGGGGGTTGTGACTGGGGGCCGGAGTGCCCCA

CCCGATTGGTGGGTCCCCTTCCGCATTTAGGGTCCCTGAGCATGCTTTCTTGCCAGGGAGC TGGAAAGTΓTTCTGACCCTTTTCCCCAGAAAGAGAGACAATAGATTGCCTTCATTTTGATG TCTGTGGCCTCAAAATTGATCATTTCCTGTCTCCTCCCTCCCTCCCCGCCCTGGGGCCCCCC GCCCATTCATCCCCACCCCTCCAGAGCCACTTANGACCCACTTCTGACTAATTATGGATTC CAGATGCTTGGGATAAAAGAAAAAGGACCAAGAACCCCTCCCCCTCTCTGACCTGGCCAA

AGCCCTCCCCCAATCCCCAGGTCTCTGGAGGGCTCTGCTTAAGCCCGCCTCACCGANAGN AGGNATGTAGCTGTAGAAACAACCATGCAAACTGGGTGGCCTGCAGTTTACACCACCCAA TCTTCCCTCCTGGCTCCTTACATGATGAGGACAACTGGCTGAGAAGGGCGCAAGCGTCTG GCTCACTGCTATTCTGAAATAGAACTGGCTCTTGCTGGCGTGGCCTGGGTAGGGCCGGCA GAGGGG

>'000203a-023.scf came from CONTIG 22 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-023.scf(l>640)

GTCAAATGGCCCCGCTACATCCGGCTGCAGCGGCAAAGGGCTATTCTTTATAAGCGCCTG

GAAGTGCCTCCTGCAATTAACCAGTTCACGCAGGCCCTGGACCGACCAACAGCTACTCAA

CTGCTTAAGCTGGCCCCAAGAACAGACCACAGACAAACAAGAGAAAAAGCAGAGCTGCT GGCCGAACTGAGAAAAAAGCGCGGGCAAAGGCGAGTCCCTACCAGAGCCCACTGTCCTTC

GAGCAGGTNCACACGGCCACACCTGGGGAAGACAGAAGCTCAGTGTTGTGATCGTCAGA GTGGTCCCTTGGCTGGGGTCTCTGCTGCCTGGGCGCAGAGGGGNTTCTATGCTATAAGGCA GGCGGCTGGCGCGTGCCAGAGACGGCCACGACTTACCATCACGGGAAAGAGCTGTTAGG GGAACCAGACATTAAACAAAAAGAACGGGTGGGGGAGGCGGGCA

>'000203a-024.scf came from CONTIG 23 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-024.scf(l>602)

CGCCGCCGCTTAAACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGATTACAAGCG GATAGAAGGGCTAAAAATCAAAGGCGAAGAGTTCATATGACTCTGGAGTTACCATGGAGT GCTGATAGAGCAATTCAGCAATTTGGACGAACTCATAGATCAAATCAAGTTACCGCTCCT

GAATATGTCTTTCTGATTTTCTGATTGGCAGAAGAACAAAGATTTGCATCTATTGTTGGTA AAAGACTTGAGAGTTTGGGCGCACCTACACATGGAGACAGAAGAGCAACAAAAACTAGA AAACCGAGCCGCGTCCACCTTCGATAATAAGATGGAAGAAAAGCTTTAAAAATTGTGATG AAATCCAATGTGAAACCAAATTCTTCCTTGGTTCACCACTCCAGACTATCCTGGAGATTCT TTAAGAGTTCGCAAGACTGATAGAGTGTCTTATAAAGTGAAAAAGTCAGAATCTTCTTTTA

TAAAATTTAAAACAAAGNAAATTTTAACAATTTGGGCGGGAGGGCCCACAAAGCCTTTTT

TTTTCGCACCCCTCCTGCGGCTCAAAGCAAAAAAGAAAAACATAGGAATTAATGTTGTTG >'000203a-025.scf came from CONTIG 24 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-025.scf(29>176)

GGGCTGCAGCTCCATGGGGTGTTGGTGCCTGCCAGCCACGGAGGCCGGGCGGCCAGAACG CGCACAGAGGGATATGATATGGTCCGGTGTGATGGAGAGAGCAAGCGGGACCGTGCAGC CTCCCAGGACACTGGCCCCGCGGGGAGCC

>'000203a-065.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-065.scf(l>665)

GTGGCGCCCTCTAAACTATGGATCCCCGGGCTGCAGGTGGACTACACCATCACTGTCTATG CTGTCACCGGCCGGGGGACAGCCCGGCAAGCAGCAAGCCCGTTTCCATCAATTACCGAAC AGAAATTGACAAACCATCCCAGATGCAAGTGACTGATGTCCAAGACAACAGCATTAGTGT

CAGGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTGACCACTGCTCCTAAAAAT GGCCCAGGACCATCGAAAACGAAAACTGTAGGTCCAGATCAAACAGAAATGACAATTGA AGGGCTGCAGCCCACAGTGGAGTATGTGGTCAGTGTCTATGCTCAGAATCAAAACGGAGA GAGTCAGCCTCTGGTTCAGACAAGCGTTACCCACCATTTCTGCACCAACCAACTGAAATTN ACTCAGTGACACCACCAGCTGACTGCCAGGACGCACCNATGTCACTCACTGGTTCGAGGC

GGNGACCCGAGAAAGACGNACGAGAAGAATCACCTGCTCTGAACTATCGGTTGTTCAGAC TAGTTGCACCAATGAGGAGGCTTGCTTTAGACCTGACACAACGCTAGGAGGTCAATTGAA AGCACTCAAAGGCCGGGAAAGTTGAACACTCCTTATGAACAAATGAAAACGGTCAGTGGC TCC

>'000203a-026.scf came from CONTIG 25 at offset 40;"E:\SEQUENCE\export\EST_db\000203a\000203a-026.scf(38>628)

AATTCGCACGAGTGTCTATGCTGTCCCGGCCGGGGGACAGCCCGGCAAGCAGCAAGCCCG TTTCCATCAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACTGATGTCC AAGACAACAGCATTAGTGTCAGGTGGCTGCCCTCAAGTTCCCCTGTTACTGGTTACAGAGT

GACCACTGCTCCTAATAATGGCCCCAGACCATCGAAAACGAAAACTGTAGGTCCAGATCA AACAGAAATGACAANTGAAAGCTTGCAGCCCACAGTGGAGTATGTGGTCAGTGGCTATGC TCAAAATTCAAAACGAGAGAGTCAGCCTCTGGGTCAAACAGCGGAACCACCATTCCTGCA CCACCCACCTGAATTACTCAGNGAAACCAACAGCTGACTGCCCAGGNACGCACCCATTTC ACTCACTGTTCGAGGCGGTGACCCGAAGAGAGACGNACGAGAAAAATCACCTGCTCTGAA

CTATCGGGTGTATAGACTAGTTGCACAAATTAGGAGGCTAGTCTAGACCTGAAGCAACGC TCAGATGTACATTGAAAGAGCCTCAAAGCCGGGAAAGCTTGAACCCTACA

>'000203a-027.scf came from CONTIG 26 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-027.scf(30>646)

CTGCAGAAATTCGGCACGAGGAGCGAGTCCTGTTAGGTGCGCGTGGAAACTAGGGTCATG GCTGCGCCCGGTCCAGCGCTCTGCCTTTTCGACGTGGACGGGACCCTGACGGCCCCGCGG CAGAAAATTACCAAAGACATGGATTGCTTTCTGCAAAAACTGAGGCAGAAAATCAAAATT GGTGTCGTCGGCGGGTCGGACTTTGAGAAAGTACAGGAGCAGCTGGGAGATGACGTTATT AAAAAATATGATTACGTGTTTCCAGAAAATGGCTTGGTAGCATACAGAGATGGGAAACTC

TTGTGTAAACAGAATATTTAAGGTCACCTGGGTGAAACCCTAATCAAGATATATTCACTAC TGTCTGAGCTACATCGCGAAAAATCAGCTCCNGAAAAAAAGGNCACTTCATAGAGTCCGT AACGTGAGCTGACGTGTCGCCGACGGAAAAGCTGCAGCAGAANAACCATGTATCTACGAC TGTACAAAAGAAACATAAACAAAGTCGGAGNATTGCAAAGATTGCTGTAAGGCTACGTTT CTAGAGNCAATCACTTATTCTCCCTAGCTGAACAATACGCTGGAACGGGAAGAAGATAAA

CTTATTTTTGGACAAC

>'000203a-028.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-028.scf(40>622) CACGTAGGGGCGACCGCAGGCCCTCTCCCGAGGAGCTGGACAAGGGCATCGACCCCGAG

AGCCCCCTGTTTCAGGCCATTCTGGACAACCCCGTGGTGCAGCTGGGCCTGACCAACCCG AAGACCTTACTAGCATTTGAAGACATGCTCGAGAACCCGCTGAACAGCACCCAGTGGATG AACGACCCGGAGACGGGCCCGGGCATGCTGCAGATCTCAGAATCTTCCAGACCCTGAACC GCACATATGCCGCGCACTGCAGCTGCCAGCCCAGAGAGCCTCTTCTTCCCAGCCCAGGGG TGGGGAGAGGGTGCAGACCCCAAGGTGCGCCTGGGCTGGGGGCGGGGAGCAGGGGGGCN TGGAGGGACCCTGCCCCTGGGTGTGGCGCCAGGCCGCACTCCGCTGGATCTTCTGGAAAA ACTCGGNGGCAGGGCCGGGTGGCTCCACCCCTGACAGGTTACGACAGGCGCCACCGGGA AGGGGGCTCCTTCAGGCCCTGGCTCTGACGTATTGATTAACGAGCGCGCTGGAAGACCTG TTTGAAAAAGAATGTCAACCAGTTAGGAAGGATAATGGGAAAAAAA

>'000203a-029.scf came from CONTIG 28 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-029.scf(35>595)

AATTCGCACGAGGTCATCCCTAAGTGGCCTGAAGATGGACAAAGGGAAGTAACAGGCAC GTGATGTTGGCAAGGATGCTTCTAGGGCTAGAGGATCAGTGGTGGGAGAGAGCTGCAGAA

TCCACCAGCCAGAACTGCAGATAACGATATCTATGGTCAGGGGCTGTGACTGAGAGAAGG AAACTGAGGTTGTGTTCTGAAAGTACATAAACTCTCACATATACCCAGTTCTTCACCATCT TCCCTCCTCACTTTGCAGNGCCATTTTTTTTTTGCATTAGGCAAATTGCTCAGACT^ AGCCATGCCCATCCCGTCTCTGGAACCCCCACACCTCTGAGAGTGGGATCACCACGTCCTG CAGGGCTGCTCCCCTCCAACTACCTTTAGAGAGCAGGACAGGAGCTGTTTCACCACAAGA

CAAAATCAAACGAGAGCAGACGGGTAAACAAANAAGACAGGGGCAATGTTTTCTTGNGT

TTTTTTTTTAACAAANA >'000203a-030.scf came from CONTIG 29 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-030.scf(36>676)

CTCATCCTACCATATAGATATTGGTACCCTTTATCTACTATTTGGTGCTTGGGCCGGTATAG TAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGGAACTCTGCTCGG AGACGACCAAATCTACAACGTAGTTGTAACCGCACACGCATTTGTAATAATCTTCTTCATA GTAATACCAATCATAATTGGAGGATTCGGNAACTGACTTGTTCCCCTAATATTTGGTGCTC

CCGATATAGCATTTCCCCGAATAAATAAATAAGCTTCTGACTCCTCCCTCCCTCATTCTACT ACTCCTCGCATCCTTATAATTGAAGCTGAGGCAGAAACAGCTGAACCGNGNACCCCTCCT TANNCAGCAACCTACCATGCAGGAGCTNATAGAACTACCATTTCTTTTCACTTACANGAGT CCTCATTTTAGAGCATCAACTCTTACACAATACAACATAAGCCCCGCATGCCATACAACCC TTGTGTTGATCGNATATACGCGACTATATATTGCTCTTTTACACGCACCAGCTTTAAACGA

ACTATCACTCTCACGCGAGAGAACTTTTTTACATTTTGTTTTGGCCCGAGCTTTTTTTC GGGATTCTTTGCCCCTCAAAAAAACAGTA

>'000203a-031.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-031.scf(13>195)

TTATTACATAAATAAAAGCAGCACGCTTTTATTTTCTATTTAAATACCATACACGAGATTT AAAATCACATTTGGCAGTGGACTGCAGGATGCTCAGACTTCACCCACATCACNTTGGATT >'000203a-033.scf came from (F3, 033) no description length

779GGCGCCCTCTAAATATGGATCCCCGGGCTGCAGGAATTCGGCACGAGGCCGGACCGGT GTCCTTCTCTGGAGGCTCCTCGCTGGTCGTGGGGGAGCCGGGAGGGCATGGCTGGCTGCC CGAAAGAGACTGCGAGACGGTGACCTGCTGTCTCTTTTCGGAGCGGGACGCCGCCGGAGC TCCCCGAGAAGCCGGCGAACCCCTGGTCGGGGCGGCCCTAGAGCCAGAGGCGGTGGGCG

GCCAAATACCGCCCGCCTACCTGTTTCCCCGGACAACAACACGATTATTATCCCTTGCTAA TGAAAAACGCCCCCTTTCATCCGGAATCAACCACTGCCGCCCCCACCACCTGGCGGGGCT GTACGGCGGGGGGCTCCCTCCCCCCCCCCATTTCTCTCTTTTTTTTCGTCTCATTACATTTG GGGGCTATATATATAATATATTATTATAGATATTATTTTC

>*000203a-034.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-034.scf(28>623)

GGGCTGCAGAATTCGCACGAGGCTGTCTGCTCGTGGTGGAGATGGCAGTAGGATCATTTT TGATGATTTTCGAGAAGCGTACTATTGGCTTCGTCACAATACTCCAGAGGATGCGAAGGTC ATGTCATGGTGGGATTATGGCTACCAGATTACAGCTATGGCGAATCGGACGATTTTAGTG GATAATAACACGTGGAATAATACCCATATATCTCGAGTAGGGCAGGCCATGGCATCCACA GAAGAAAAAGCCTATGAGATCATGAAGGAGCTTGATGTCAGCTATGTGCTGGTCATTTTT GGNAGCCTCACTGGGATTCTTCAAATGACATCAACAAATTTCTGTGGATGGGCCGGATTG GAAGGAGCACAGATACAGGAAACACATACAGGACACGATATTATACTCCACTGGNGATTC

GNGTGGACCCGGAGGCTCCCANGCTGCTCACTGCTTTAGACAAAAGGGTACTACGATTGA CAGGNTACCAAAACCACGGCCCTAGCTTTACCGGCCGGATGCGAGATGGAATAAACTCGA CTGAGTCTAAAAACAACACACCACATGCTGGCGAATTCAAGGAGACCGNAATCAG >'000203a-046.scf came from CONTIG 32 at offset

0;Ε:\SEQUENCE\export\EST_db\000203a\000203a-046.scf(37>597)

NAATTCGGCACGAGGGCATGAATGTCCTGGCCGATGCTCTCAAGAGTATCAACAATGCCG AAAAGAGAGGCAAACGCCAGGTCCTTATTAGGCCGTGCTCCAAAGTCATCGTCAGGTTTC TAACAGTGATGATGAAGCATGANTACATTGACGAATNTGAAATCATTGATGANTCACAGA GCTGGAAAATTGGTGNGAACCTCACNAGCAGGGCTAATAAGTGTGGAGNGATCAGCCCTA

GATTGATGTGCAACTCAAAGATCTAGAAAATGGCAGAATACCTGCTCCATCCCGCAGTTG GTTTCATGTACTGACAACTCAGCTGCATCATGGACATGAAGAGCAAGACGAAACATACAG AGGAAATCTTGATTCTTTTTAGGAGTATACTACAATAATGCTCAAGACTTGTGCTTCTTAA AAAAAAAAAAAAAACGACCGCACTGATGACAGATCTACATATTCTGACCTTTTTATCTCA CTAAAGTCAACCACTTTTCCATCAACGAACACAAAATAAAAAAAACCCTGAAAAAAAAA

>'000203a-035.scf came from CONTIG 32 at offset 542;"E:\SEQUENCE\export\EST_db\000203a\000203a-035.scf(38>379) TTTTTTTTTT CCTTTCTC

ATTTTCTTTAAATTCGACACAGTTATGTTAAAAAATATATGCATTGTACTTAGAGTTTGGT GTAATTTAAAATATGTGGAGTGATTTCATTCACTCTCCTGTTTTAAACATTTGTTAAGGACT CAGCATGTGAAGGAGCAAGAGATATAGTCATTTTTATTAGAAAACTTCAGTGTTCTAATTT CATCAGAGACCGNGAATAATCAGAAGATGACATGATTTACTTGGAATATACAGCTTATCA AGGACTTCGTTATTTATGATGGTTATTTAAAATC

>'000203a-037.scf came from CONTIG 33 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-037.scf(37>554)

>O00203a-038.scf came from CONTIG 34 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-038.scf(38>594)

>'000203a-040.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-040.scf(29>585) GGGCTGCAGGTTAATTCATTTTTCTGGAAAAAGAGAAGATGTTTATTTATTTATTTπ GGTAAATTCTTTTGAATCTGCCTCTTAAACCTAACTCTGGGCTCTCTCAGGAGGGGCAAAG AGGACCTTTGAGTTAAACCCTCCAATGGAGACCCTGGGAAAGAACCGGAGGCATAACACC CNAGCCGCCCTCCAACTGGACTGTANGACTCCCCAGACCCGCTGCCCAGCTGCTTCTGCCC ATCGNTCTGCCTGGTTGGGTTNTGGGTCCTGGATCCCACCCGAGCCCTGTAGGATGGCACC

ACAAGCCCTACATGAAGAGCTTTGTGGTGTCACTAAAATGTGTGTTTCGGCACGTTGCTGT CATTCTGCCTGNCTGCCATGCTGAAAAGCTGGCACAGCCCGANAAGCCAGCGAAAACACC TTCTGCCAGANCTCTGNCCCACTCGAGATGAGACCACCAGCTGCTGTCCTCCCAGAACAG GTATTATATTTAAGTAAAACTGTTACTAAAAAGTTTGTTCCAACTTATTCAAAACAAGAGA AAAGGGGCGT

>'000203a-041.scf came from CONTIG 36 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-041.scf(l>593)

GGGGCCCTCTAAACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGCGGACCTGCTG GAGCTCCTGGCACTCCTGGACCTCAGGTATTGCTGGACAGCGTGGTGTGGTCGGCCTGCCT

GGTCAGAGAGGAGAAAGAGGCTTCCCTGGTCTTCCTGGCCCCTCTGGTGAACCCGGCAAA NCAGGTCCTTCTGGAGCAAGTGGTGAACGTGGCCCCCCTGGTCCCATGGGCCCCCCTGGA TTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTCCTGGTGCTGAANGATCCCCT GGACGAGATGGTTCTCTGGCGCCAAGGNTGACGNNGTGAGACCGNCCCTGCTGACTCCTG TGCTCCTGCGCTCCCGGGCCCCCGNCCCTGTCGACTGCCGCAGACGNNGACGGGTGAGAC

GGCCTGCTGTCTGCTGTCCCATGCCCGTTGTGCCGGGCCCGTGNACCCAGCCCCCGGGACA GGTGAAAGCGACAGGGACGAGCATAAGTCACGNGCTCTTGTCTCAGTCCCCGCCTCCGCT TCTGGAGCAGTCTTCGACTTGTCTGTGGCCGCGCCCCGTTTTGTTCTCGCA >'000203a-047.scf came from CONTIG 36 at offset

42;"E:\SEQUENCE\export\EST_db\000203a\000203a-047.scf(41>502)

CACGAGGACGGACCTGCTGGAGCTCCTGGCACTCCTGGACCTCAAGGTATTGCTGGACAG CGTGGTGTGGTCGGCCTGCCTGGTCAGAGAGGAGAAAGAGGCTTCCCTGGTCTTCCTGGC CCCTCTGGTGAACCCGGCAAACAAGGTCCTTCTGGAGCAAGTGGTGAACGTGGCCCCCCT GGTCCCATGGNNCCCCCTGNATTGTCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCT

NCTGGTGCTGAAGGATCCCCTGGACGANATTGTTCTCCTGGCGCAAAGGTGACCGTGGTG AGAACCGGCCCTGCTGACCCTCTGTGCTCCTGCGCTCCCGTGCCCCCGNCCNTGTCGACTG CCGCAGACGTGATCGTGGTGAAACAGGCTGCTGTCTGCTGTCCATGNCCNGTGTGCCNGG NCCCCTGNACCCAGACCCGGTGACAGGGAAAAGCAACAACG

>'000203a-042.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-042.scf(l>652)

CGGCGTCCCTCTANACTATGGATCCCCGGGCTGCAGTGGTTCTGCAGCTCTGTGGCAAGCC GCGGAGTCTGGGTTCTGATCCGCAGGATGGGGTTTGTTAAAGTTGTCAAGAACAAGGCCT ACTTCAAGAGATACCAAGTGAAATTCAGAAGAAGGCGAGAGGGCAAAACTGACTACTAT

GCTCGGAAACGATTGGTAATCCAAGATAAAAATAAGTACAACACACCTAAATACAGAATG ATTGTTCGTGTAACGAACAGAGATATCATTTGTCAGATTGCTTATGCCCGTATAGAAGGAG ATATGATAGGTTGTGCAGCTTATGCTCACGAACTCCCAAATATGGNGTGAAGGNTGGCCT GACAATTATGCTGCGCATATTGTACTGGCCTGCTGCTGCCCCGCAGCTTCTTTATAGGTTG GATGGACAAAATTATGAAGCNAGACGAGGNGATGGAGAGATACATGNGNAAGCATCGAG

CCAACTGGGCCTCACTGTACTGNAGCAGACTGCAAACTCTACGAGTTAAGTTTGGCCCTA GGACGCGAGAGCTGCTTTCTACAGACACGTCCTGTTGATCAAAGCAAATCAGCGAGCCCG AAGCATAGGCAAAGTGAATACGCCCCTGTGGAAAAAATCCAAAACTTTTCA >'000203a-044.scf came from CONTIG 38 at offset

0;*'E:\SEQUENCE\export\EST_db\000203a\000203a-044.scf(l>627)

CGGCGCCCCTCTACAACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGCAGGACAA TCAAGTGTGGCAGCTGGGCTCATCGTCCCCAAACTTCACTCTGGAGGGACATGAGAAAGG TGTGAATTGCATTGATTACTACAGGGATGGTGACAAGCCATACCTCATCTCTAGAGCAGAT GACCGTCTTGTGAAAATATGGACTATCAGAATAAACTTGTGTACAGACACTGGAGAGGAC

ATGCCCCAAATGTGTCTTGTGCCCAGTTCATCCTGAGCTGCCCATTTTATCACAANTTCAA AAAATGAAACTGGCGTTTTGGCATTCAAGCACCTTCGCCTTGAGAGGACTTGATTATGAAT GGAGAAGAGATGGGGGGGCCGCCGCGAGGTCCATAACGTGTTTTGGCTTTGAGAAAGAA GCATATGTTAACTTGTCGGAGAAcfGCTTGTCTGGTGCCAAGGAAAATAATGGGCCAACA TCAAAATCACCAGCCACTAAACAAGGAGAGTGTAATTAAAGAAAAGATGCCTGCATAAA

AATGCAGTTGAATTACTCAATATCACAATCTAAGCGCGGTGGGGGGGGGGGGGAAATTTT

TCCGCAGCCCGAAACAATGTGGGCCG >'000203a-045.scf came from CONTIG 39 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-045.scf(44>624)

GCACGAGGCTTGCCTGCTGCCTGCCTGCCTGCCACTGAGGGTTCCCAGCACCATGAGGGC CTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAACAGCAAGCC TTGCCTGATGAGACAGAAGTGGTGGAAGAAACCGTGGCCGAGGTGGCCGAGGTACCCGT GGGAGCCAACCCCGTCCCAGGGGAAATAAGAAGAATCGATGATGGTGCCGAGGAAACCG

AGGGGAGAGTGGGGANCGAGAACCCCCGCCAAACCACCACTGCAACACGGCAGGNGTGT GAACTGAACGAGAACACACCCCATGGTGTTGGCCAGACCCCACCACTGCCCTGCCCNTCG CGAAGTTGAGAGTGTGCACAACGACAACAGACTTCGATCCCTGCCATTTTTGCACNAGGN ACATGNAGGCACCAAAAGGCCCAACTCACTGNCTACTCGGCCTGAATACATCCCCTGCTG CATCGACTGATGATCCTGGCTGCGACGCTAAACGCCGNCACTGACAAGGAAGCACACTCG

ACGAAAATATGGATGAAAAACCAAATAAAGCCGGGGGGGCCTC

>'000203a-048.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-048.scf(38>559) TTATACTCCAAGGCCTGGCAAAATCACATAATCAAGATTGAATTGTTTCAGAAATATTGGC

AGGATTCTTGGACTGTGTCTACTACAGAATGAACTGTGTCCTATCACATTGAATAGACATG

GATGTACGAGAAGTTGCGGGCACTTATTCTTGCTTCTCANAGTTCAGATGCTGATGCTGTT TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTTAAGAGAAGAGGGGAGACAGN TGAACTATTTNCTATGTGTAATATACCAGTCACTCTCAAATGTTATGAGTATGTGCGGAAT

ATGCTGACATAAATGTNNGTAGTGCAGACACCATACTGCATGAGAAGTCTCTGNTGTGCT TCAAAATCATATANATTACACAGAAATTAGCTTTGTTAGCTGGNGAGNTACGGCGAGCGT CAGTCACTCTTCTGAGATAGAAAAGTGAACTTGCGTC >O00203a-049.scf came from CONTIG 41 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-049.scf(l>306)

GGGCGCCCTTAAATAGGATCCCCGGCCTCAGGGTGGCAAGAGGCCGTGCTATTTTTTTTTT TGTAGAAGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAACGAGTTTCTCACTCGGGA GCTGGCTGAAGATGGGTACTCTGGAGTTGAGGTCCGAGTTACACCAACCAGGACAGAAAT CATTATCTTGGNCCACCAGACACAGAATGTACTTGGTGAGAAGGGCCGGCGGATCCGGGA

ATTGACTGCTGTGGTTCAGAAGAGATTTGGCTTCCCTGAAGCAGTGTAAAGCTTATGCTGA AAA

>'000203a-050.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-050.scf(39>525)

NAATTCGGCACGAGGCTAGTCTCGAGTTTTTTTTTTTTTTTTT^ TGCTTTATTTCATTTTTTTCACAATTTATTTAAACATCTCACATATACAAAATAG TTAATTTTTCTGCTTGTCCGAGAAACAAGACTTCTTTGGAACCATGGNAGAGGATGAAAAT GAGACTGGCAAAGAACAAATGCTGAANTTAAAGAAGAGACAANTGTGGGCAAATGATCC ACTTACTTTTGTGGAATAAGATGTAAAGTACTGATGTTAAAGTCAAATGAAAAAAATACA

CAATACAGCTCAACAGCAGAGGAGTATCTCTTCTCAAATTCTCCTAGCACCATCAACATTC TTNCAGTATCTGAAATACTGTTAATTAGCACCTTCGTATTTTGAACNAAAAAACACAAATA CCTCAGCTCATCTCTGGTCAGCACTCACGGTGTGGTATCACACTCACAGGAAANGTTTTGA >'000203a-051.scf came from CONTIG 43 at offset

0; "E:\SEQUENCE\export\EST_db\000203a\000203a-051.scf (38>406)

NAATTCGGCACGAGGATCATATAGTAAACCCAAGCCCTTGACCTCTTACAGGAGCTTTGTC TGCCCTCTTAATAACATCCGGCCTAACCATGTGATTTCACTTTAACTCAATGACCCTGCTA ATAATTGGCCTAACAACAAATATACTAACAATATACCAATGATGACGAGATGTTATCCGA GAAAGCACCTTTCCAGGGGCACATACCCCAGCTGTCCAAAAAAGCCTCCGTTATGAATAT

TCTTTTTATTATCTCCAAGTACTATTCTTTACCGATTTTTTTGAGCTTTTACCACTCAG GCCCCACCCCTGACCTAGCGCTGCTGACCCCCACACGCATTCACCCACTAACCCCTACAAG TCC >'000203a-053.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-053.scf(37>515)

TGAGAGCAGCAGCCAAAAACCACGCTCGAGTGACAGTAGTATGTGAGCCGGAGGACTAT GCAGCTGTAGCCTCAGAGATGCAGGATTCTGACAGCAAAGACACGTCCTTGGAGACAAGA CGCCAGTTAGCCTTGAAGGCTTTTACTCATACAGCACAGTATGATGAAGCAATTTCAGATT

ACTTCAGGAAAGAGTACAGTAAAGGAGTATCTCAGATGCCCCCTGAGTATGGAATGAANC CTCATCAGACTCCTGCCCAGCTGTATACGCTGAAGCCCAAGCTCCNTTATCACAGTCTGAA TGGAGCCCNTGATTTATAANCTGGGTGATGCTTTGAATGCCTGCAGCTGGTGAAGGAACT CNAAGAGCTTTTAGCTTNCACTGCTGCGTCTTCAAACATGTAGCCCACAGGCTGCTGTTGG ATTCACTCATGAAGAGAAACCACTCTGCATGTTATGATTGTACAAACCTCCACCGCA

>'000203a-054.scf came from CONTIG 45 at offset

0;Ε:\SEQUENCE\exporf\EST_db\000203a\000203a-054.scf(40>404)

CCTAAATTACTCAATAGTTTTAAAGTGTTACATATTCAAAGCCTTTTCCAGACCAGGGAGA GAGTTCTGTTAGAGTGAAGGGTAGTGTCTCTTGCGCATTCTGTGTGTGTATTTCTAAATGC

TACTGTGTGTGTTTGTGTGTGCTCCCACAGTTTATATGCAAAGACTTTGAGCAACATTTAT AAAAAGTATTTTCTCTTAGAACAATTCAAGAGATTTATTTTGTGGCTACCACAGNCACTGC CAGTGGATTGTTTTTTCTTCTAAATCTGAATATTGACCAAAAATTTGGTGATTTTTATGACT TTGTTGTGTTGGTGTTTAATTTTCTTAAAAATTTAAACTTTGGTTAAAATTCAGAAA

>'000203a-055.scf came from CONTIG 46 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-055.scf(l>728)

GTGCCTCTCCCTATACTATGTAfCCCCGCGCTGCAGTATATTTTGCATGTAGGAGAACATG TAATCTCTATCTTCCCTTAGCAGGATCAAACCTAGGGCCTTCTGCATTGCGAGCACAGAAG CCTATCCTCTGGACCACTTGGGGGAGTCCCCGCTTTTCTTTGCATCCCAAAGAATATTATA

ACTAACCTAAAGAAAACCGCATTTTCCCCTTATCGGCGCGCTTCTTTCCTTTAGTCTAAGA CAATAATGTCTTATTGTCCTGGGGGGGACATAGTCAGTACGGGTTAAGCTCCTCTAACCTT

AAATTCCTTCTGCCGCCCCCCACTTGGGGGTGGGTTGGCCTCTTGGGTCTTTTCTTAATAAT AAAACAAAACGGTTTGACTGTGTCTCCCCCAGGTACTTTTTTTTCTCTCTTTCAGAGTACTG

TCAACCGGACTCCAGTTTTCTCCTGGGACGTCAAATTTTCCTACTCTCATCGCCTCTGCTGT GGCCTTTTTCCATTTCAAGAAATTCTCGACCTATTATTCACTCCTTAAAAAATATATCATGC CCCCCCCCTCTACTTGCTTCGCGACAGACACAACAATTTTCTTCTAAGCAGGCGAACCACA ACAGAATAGGAAGATATCTATACAGAAGGAAAGAACGTATTCATGGCGATCT

>'000203a-056.scf came from CONTIG 47 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-056.scf(17>140)

>'000203a-057.scf came from CONTIG 48 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-057.scf(10>722)

CTCTATACTATGGATCCCCGGGCTGCAGNAATTCGGCACGAGGAGGTATGTCTGAATGTG TTTCGACTATTTACAGCCCCCTTTCCTCGCAGGGCCCCATGAGTAAGCTGTGGCGGCGCGG

GAGCACCTCTGGGGCTATGGAGGCCCCTGAGCCTGGGGAAGCCCTGGAGTTGAGTCTAGC GGGTGCCCACGGCCACGGAGTGCACAAGAAAAAGCACAAGAAACACATGAAGAAACACA AGATAAAACACTACCAGGATGAAGAGGCTGGGCCAACGCAGCAGTCTCCTGCCAAGCCCC AGCTCATACTCAAATCAAGTTGGGCGGGCAGGTCTTGGGCACCAAGAGTGTTCCTACCTTC ACTGTGATCCCTGAGGTCCTCGCTCACCCCTCTCCCTTATGTNTGGGAACATGAAGAGTAC

CTGTGAAGGAGCCCCCTGACATACCGCGCTGCTGGAGAAACAAAACTGCCCCTCCCATGG GNACTGCTGNGGNTANAGCCAGAGAAGAGAATACGAGGGCTGAGCTTGNAAAGGGAGCG AGACAGAAACCAAAGAAACAGACGCTGCACGTGCAGAGTTGTGAAGCCGAGCACTCCGG TGCCTCTGCTGGCTGCGGCCCTTACAAAAGGGGAGGGGGGGCGGAAGGGGGGGAGGGGC GGGAAAAAAAAAAACCCCAAGAGCGGGGGGGGGGGCGGGGGGGGGGGGGCCCCG

>'000203a-058.scf came from CONTIG 49 at offset 0;Ε:\SEQUENCE\export\EST_db\000203a\000203a-058.scf(38>620) NAAAGACTTCATGAAGGAGAAGAAAAGGAAAAAAATCAAAGGATGACTACAGCCTCTCT TCATCTCAGCTTTGCAAAGCATGACTCAACAGAGAGATCACATTCTTGAAGACTCTCCAGA CCACAGATTGAAGATAAGTTGTTGTGCTGCACTATTTCTGTTGCTACTCGTGAGAGTCACT ACCAGCCTCTCTTCTCAGGATTAATGAATGGGCCAGAAACCGGGGGCAGAATGACTNCAG GGGCACCCCCAACACCAGATATTGGCATAAGGAAACAGTACAATGAAAAAAGTCATACTT

GGACCCTTGTCATTCCACANAGCATGATGTACTATCTAAAACAAAAAGAAGAGCTGCTTT GGAGAAGGGTTTTAAAAGTTGTTTATCAAAANAAAGATTANAAGAGGAAAACTCCAGTNT ATNAGATGGCATTTACTTTNAAGGCTCTGTCCCTGTGTAGGCATGAGATTGATACAGNACA GACGGGCTGCCAANCAGNTACTAATGTNTCTGCTCTAAGAAGGGNCCTCTTGCTTCCTTGT GATATCTTGCAGAGCCGACTGAGGACAGAAACACAATAAG

>'000203a-059.scf came from CONTIG 50 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-059.scf(39>620)

CAATTCGGCACGAGGGTGAGTGACATCGTCTTTAAACCCTGCGTGGCAATCCCTGACGCA CCGCCGTGATGCCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCA

TCCAACTTCTGGATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAA GCAGATGCAGCAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAA CACGATGATGCGCAAGGCCATCCGAGGGCATCTGGAAACAACCCGCTCTGGAGAACTGTG CCTCACACCGNGGAATGTGNNGCTCGGTCACCAAGAGACCTACTGAGACAGGACAGCTGC TGCCACAGGGCCACTGCGCCCGGCTGTGCATACGCCGGGAGACCTGGCCACCAGACATGN

CTGGGCCGAAAGACTTCTCTCAGCTTAGCACACACGATACTCAGGCACAGAACCTGAGAG GCATGATAAAAGAACAGAGCGCAGAGCACGCGACACGACACCCCTTCCTGCGCCCCAAG GGGAAAGCAGATACCCAGCTAAAAAGACCGCTCCTCGGGGGG >'000203a-083.scf came from CONTIG 50 at offset

7;"E:\SEQUENCE\export\EST_db\000203a\000203a-083.scf(45>614)

GCACGAGGGTGACATCGTCTTTAAACCCTGCGTGGCAATCCCTGACGCACCGCCGTGATG CCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCATCCAACTTCTG GATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAAGCAGATGCAG CAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAACACGATGATG

CGCAAGGCCATCCGAGGGCATCTGGAAAACAACCCGGCTCTGGAGAAACTGTTGCCTCAC ATCCGGGGGAATGTTGGCTTCGTGTTCACCAAGGAGACCTCACTGAGATCAGGGACATGC TGCTGGCCAACAGTGCCAGCTGCGCCCGGCTGTGCCATACGCCGGTGAAGCCTGGCCAGC CAAACATGTCTGGGCCCGAGAGACCTCTCTTCAGCTTAGCACACAGAANATTCAGGCACA TGAAATCTGAGAGGCACGATAGAAGAACAAGAGCGCACGAGCAGCGTGACAGCGACACC

CCTTTCTCGCGNATCACAGGTGACAGCAATT

>'000203a-060.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-060.scf(l>262) GGGCTAACAGTCCGCGAGCCCGGCAATCCGCAGCCGGGCCCACAGGAACATGCGTCTGCT

TGGGGGGGAGAGGGCCGGGCTAGAGCGAGCAAGGTGAGGGGGGGGGGGGGGGACCTCC CGCGGATACAAGGTCACACACCCCTCCTAATGCAGAAGGCGACGGTTGCAGGAAGGGCA AAATAAGGACTCGCAAGGTGTCTAGGGGAACGAGTAAATGAAAGGCCACGGCGCGAGAC GCGAGCGACCACCCAGGAGAACCGCG

>'000203a-061.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-061.scf(39>494)

NAATTCGGCACGAGGGTGAGTTTCATTGAGTTAAATAAATACCTTTTGGAAAGGAGTTTG CCGATGCACCAAAAAAGCCTGTCTGCGCTGTAGGAATGTGTGGTGAAGCTCAATTTCTGTT TTATGAAACCTGTTTGGGCGGGGGTCTGGGGGTTGCACAGAGAATGAGTTCTTGTATTTCG

CGTCACACAGGTAGTTATGGAAATATGTTATTGTACTGTGTAAAGATGCCCAGCCATTTTG ATTGTTTGGCTTTTTACTTTGTACCTTTTCAAGCTTTTGCTATACAT^^ CATACTGTGTTGTAC1TCCTTTTGTAATGATTTTTAATGGAAGTTTGCACATAACTCTTGTT ATACTGTACGATAATCTTGGGGGAAAATATTTTGCATATCAAAAAAAAAAAAAAAAAAAA ACCGAGGGGGCCCGCCCCCATTCCCCTTA

>'000203a-062.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-062.scf(l>630) CGGGCGCCGTTAACTAGGTCCCCGGCTCAGCAGACACAGTGTCGTGAAAACCACCGTTAA ACCTAAGCCAAAATGGGAAAGGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTA GATTCAGGGAAGTCTACCACGACTGGCCATCTGATCTACAAATGTGGCGGGATCGACAAG AGAACAATTGAAAAGTTCGAGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCNAATA TGCCTGGGTCTTGGACANACTTAAAGCTGAACGNGAGCGNGGNATCACCATTGATATCTC

CCTGTGGAAATTTGAGACCAGCAAGTACTATGNTACCATCATTGATGCCCCAGGACACAG AGACTTCATCAAAAACATGATTACAGGCACATCCCCAGCTGACTGTGCTGTCCTGGTCGGT GCTGCTGGGTTGGNNGAATTGAAGCCGGATCTCCAAGACGGCAGACCCGNGAGCTGCCTT TTTGCTTACACCTGGNNGNGAAAACACTATTGTGCGNNTACAAAGGATNCACTGACACCT ATACAGAGAATCAANAATGTTAGNANCACACTTATANAAATGCTCACCCGACANACATTG

GCCATTTGCTGAAGGACAAGCTAACAAGCT

>'000203a-075.scf came from CONTIG 53 at offset 27;"E:\SEQUENCE\export\EST_db\000203a\000203a-075.scf(41>615) CGGGACACAGGTGTCGTGAAAACCACCGTTAAACCTAAGCCAAAATGGGAAAGGAGAAG

ACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCAGGGAAGTCTACCACGACTGGC CATCTGATCTATAAATGTGGCGGGATCGACAAGAGAACAATTGAAAAGTTCGAGAAGGA GGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGGTCTTGGACAAACTTAAAG CTGAACGTGAGCGTGGTATCACCATTGATATCNTCCTGTGGNNAATTGAGACCAGCAGTA CTATGNTACCATCATTGATGCCCCCAGACACAGAGACTTCATCANAAACATGATTACAGG

CACATCCCAGCTGACTGTGCTGTCCTGATCGTGTGCTGTGNTGGNNGAATTGAGCCNGCAT CTCCAAGACGGCAGACCCGGAGCTGCCCTTTTGGCTACACCTGGTGTGAAAACACTATGTT GGCGTTACAATGGATNCACTGACACCTTANCAGAGAATCAANAAATGTAGAAGCAGACTA TTAAAAATGCTCACCCGACAGACTTGGCCATTTGT

>'000203a-063.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-063.scf(10>605)

GCTCTATACTATGGATCCCCGGGCTGCAGCGTCACTTACCTCACTCGTTCGGAGTCGTATA TCGGGGGAAATTGCTACATTCTGTCAGGGTCACGTGATGCAACCCTTCTGCTCTGGTACTG GAATGGAAAAAGCAGTGGTATTGGAGATAACCCGGGCAGTGAGACTGCCACTCCGCGGG

CCATTCTGACAGGCCACGACTACGAGATCACTTGTGCTGCTGTCTGCGCGGAGCTCGGCCT CGTGCTAAGTGGCTCCAAAGAGGGACCATGTCTCATACATTCCATGAATGGNAGACTGNN TAGGGACTTGNAGGNTCCANAAAACTGCCTGAAACCAAANCTCATTCANGCGTCGAGAGA GGCCATTGTGTCATTTTTATGAAAATGGGCTCTCTGCACATCATGTAACGGAAAGCTCAGC CACATGGAACGACATACATAAGGCATCACTGACGGNATGGCAGACTGCTCACGGAGAAC

AGGGGGCTCAGTCTGCGGGTCGACTAACATGTCGCTACAGTGGAGCGGATCGGCTGGCTG CTAACAAGGCGCTGTGCTCCTAGACACGTGTTCACATCACGGGACCAACACCCT

>'000203a-064.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-064.scf(44>603)

GCACGAGGCCTGGACCCCCTGGTCCCCCAGGTCCTCCCAGCGGCGGCTACGACTTGAGCT TCCTGCCCCAGCCACCTCAAGAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATG ATGCCAATGTGGTCCGTGACCGTGACCTCGAGGTGGACACCACCCTCAAGAGCCTGAGCC AGCAGATCGAGAACATCCGGAGCCCTGAAGGCAGCCGCAAGAACCCCGCCCGCACCTGC CGTGACCTCAAGAGTGCCACTCTGACTGGAAGATGCGAGATACTGGATTGACCCNCACCA

NNGCTGCACCTGGATGCCATTAANNGTCTCTGCACATGGAACCGGTGAGACCTGGTATAC CCACTCAGCCANGTGGCCCATATAACTGTATATCACAGAACCCAGTAAAAAGCACGTCTG TACGGGAGACTGACGGCGATTCAGTCGATTGCGGCAGGGTCGACTGCGAGGGCATCATGA TTCTGGCTGAGNCACGAGCTCAAAATACTACATGAGACAGGNCTATGACACAATGCACTA AAGCCGTCTCAGCTCAGATGA

>'000203a-066.scf came from CONTIG 56 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-066.scf(39>329)

GTCTCAATGTCCGTGGCGCTGAGGCAAGCGTTGTGGGGGAGAAGGGTAGCGACTGTAGCT GCCGTTTCCGTTTCCAAGGTTTCGACCAGGTCGTTGAGCACTTCCACATGGAGGCTGGCAC

AGGACCAAACTCGAGACACGCAACTCATAACAGTTGATGAAAAATTGGATATTACTACTA TAACTGGTGTTCCAGAAGAGCATATCAAAACTAGAAAAGCCAGATCTTTGGTCCTGCTCG NCATACATGCAGTCTGTAGTTAACAAACACAAGAATGGAGATGGAGGTTG >'000203a-067.scf came from CONTIG 57 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-067.scf(45>669)

GCACGAGTGGCGGATGACGCCGGTGCTGCGGGAGGGCCCGGAGGCCCCGGGGGCCCCGG AATGGGAGGCCGCGGTGGCTTCCGCGGAGGCTTCGGTAGTGGCGCCCGGGGCCGGGGTCG CGGCCGGGGTCGGGGCCGGGGCAGAAGCCGCGGAGCTCGCGGAGGGCAAGGTCGAGGAC

AAGGAGTGGCTCCCCGTTACCAAGCTGGGCCGCCTGGTCAAGACATGAAGATCAAGTCTT TTGAGGAGATCTACCTTTCTCTCTGCCTATCAAGAGGCTGAGATATTGACTTTTTTCCTGGG AGCATCCTTGAAGATGAGTTTTGAAGATTATGCCGGGCAAAACCAGACCCGGGCTGCCCA GGAACCAGTTCAAGGCGTTGTTGCTTTCGGGGATACAACGACTGGGGGCTGGTGGCAGGC CCAAGAAAATACCCTGCCTCCGGGGGCCATCTTCTGCTAAGTGTCCACGCCCGGGCAAGA

GCTTAGGGGAACANAAGACACCCCCCCGTCTGCAGGGACGGCTGGGTCCGGCGGGCCCTA CCTCCCAAGACGGCTCCTCGCCCGGCCAAACGGAGAGCGCTGACAGTCCTTGCCGGCGCT GCCCTGGCATCCAGCCTTGTCTCCA >'000203a-068.scf came from CONTIG 58 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-068.scf(40>680)

TTTTTTTATGGCTTCTTCTTTCTTTATTGGACGCTTTGTAGATGTCACGCAGGTCTAAA^ TACACCGTTAAATAATTATTTAAAAACCAACCAGGATTAAGGCCCTGGCCCAGAGCTCCA AACCAGAAGCAGAAAGGAATGGTGGCGGTGGGCTGGGGGGGTATTCCTCCAACATCACC AAAACCCAGAGAACGAGGATCCTAAGCTTTTCACAGGCCAACCCGGGCACGGGCCTGCAG

GCTGACCCTCGGAGGCCTCTGGCTGCATCACTATCAGATCAAAACCAGCGAGGAGCTGCC GGGAACAGCCAGCCGAGTCCAGACATGGACACAGTAGCTGGATGGACACGAGACGGACA GGTCCTGTCCAGCTGTGGACAGGATTCAGATGCAAGCTAGGCAGTGGGGGCAGGGGCTGG GGAGCAGAATGAAGCATGCAGGAGGGGCCCCGGGGCCTGGCTCANCCACCGGCCGCCGA GCCTCACCGTGTGGGNTCGCTGGGGNCTGGGCTCCCGCCCACACTGGACTTGAGGCTCTG

NAGCGAGAGTTCCAGCCATTGTGATGTTGCTCTCACAACAAATNCTTGCCACTGGGAGAA TTGAGATGGTGACAAACTACGCCCAAGCATGTGGATGCCAGC

>'000203a-069.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-069.scf(12>643)

CTCTATACTAGGGATCCCCGGGCTGCAGTAATTCGGCACGAGGCTCGGTTTTTTTTTTTTTT TTTTGCTCTAATTAAAATTTTTATTGAAATCTCTCAAACGTTACCAAGAAATAGTTTTTGCA AAAGGGAGGGAAGGGAAAAAACAAACAACAACAACAAAAAACAGCTAACAAGCAAATT CAACATGGGAGCTCCCTCTGCTGGTCTGCAGTAGGTTGATATGTTACAAACACATTCCCAG AGACAAATCTATTTGCTGGAGAAGGGACAAAAAACAGGTGTGTGGGCTTTGCCTCNAGAG

AGAACACTGGCATGCAGNGAGCGGGGTAGTGAAAGCAGAGGAGCAGCGCAGCGCTAAGT CGCTGGTACAGAAGTACGGGCCACACTCAGGCTATGNGTAAAGGCAGCCTGTGACTCTAT GTCTCTGCATGACTGAGACAGGTGGCAAGNAACTGGGTTGGAGCCTACTATTGTCTTGCTC TCGGGTTGCTACAACCTATGTAGGTTGCGATTAGACGACGAGCCTCAAGATTTGCGCTTTG TTGACATGCAATGCAACTAGCTGTATTACTTTAAAACTTTACCTATGTGAAAAATAATCCG

TGATCAAGGAAGGCAAAAAAACTCTTT

>'000203a-070.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-070.scf(19>728) CTACGGCATCCCCCGGGCTGCAGGTCGAGTTTTTTTTTT^

TTACATTTTAGTGCTTTCTTAAAATAAATATAATAATATAATTATCAAACATACAGTGAGA AGTAAAGCACACGTGTGAACGGCATGTCACAGGAGTTCACTCAGGACTGTTTCAACACTC AGCACTGGAGAAACCGCACAGGCCTACCTATGTACAGACGACCCAACCGCCAGGGCGAG GCCACCGCGTCCCCTCCGTCCTCATGGACACGGCCACTCCCCCTTGCGTTGAAATGACCAG TTTGCATGTTTTAACTTTTCTCTCCGπ^

AAAAATTCAAGTAACACTCCCAAGAAAAAAAAAGTGCAAACTAATAAGGGACTCAGAGT CCGGCGCCGGTCAGGGGCAGCGCACAGCGGGGGGGCAGCCGGCCGAGTCTGTCCCGGAA CACGGGGCGCAGGACCCCGCCCACTCGAGGAGGGGGGGACGGAGGCCGGCCTGGGTCCA AAGCGCCAGACCTTTGTTGAAAGCAGCACAGCCCGCGAACGAACGCAGTCCGCGGCCGAC TTCGGACCAAGGAAGGAGAGGGGGAAAAATAAAAGTATTAGGATCCTTTTATAAAATATA

AAATTTTCAAATTTTATAAAGGGCGCCCCCGGGGGGGGGGGCCCC

>'000203a-071.scf came from CONTIG 61 at offset 0;"E:\SEQUENCE\export\EST _db\000203a\000203a-071.scf(38>713) TTGACATCCTCCATTTCGCTGTGCTGAGTTAGTACAGGGAAGACGGGGAAGTGAAATGCC AACAGTAGTAGATGGGGGACTTCCCTGGTAGTCCAGTTGTTGAGACTTCGCCTTCCAGTGC TGGGGGGTGCAGGTTCAGTCCCTGATGTGGGAGCTAAGATCCCTCATACCTCATGGCCAA AAAACCAGAATGTAAACAACAGATACAATATTGTAACATATTCAATAAAGAATTAAAAAA AAATTTTTTTATAAAATATACTTAAAAAAAAACCTGACAGTTTCACAGAGAGGGCTGTGA

TAGGATTGCTCATGAGGAAATCCAAGGAATAGAAGTTTTTGATAGAGGATGATGGGAAGT GTGTTAGCAGAAGTAGGACTGCCTACTGTCCATCTGGACCATGNAAAGCACANATTCATC CCGCACAGCTTGGAGAGAATGTCTCACTAAGAGCTCATGCCTTGTATTCCTCCCACATTAT TTGTATTGTTGGTTTTATATACGTTTTTTTGCTGATATTACCATATTAGGTTTGTGT^ TGTAGGACATTCTATGTAGAGAAAGATAAACTTAAAAAAGAAGCCCTTTTTCTTTTTTT^

TTAAATAATGCATCTTAAGTGAGTCACCCTTTCGGCAAAAAAGAGAACACTTTACTTATTA CTATTTCTT

>'000203a-072.scf came from CONTIG 62 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-072.scf(38>334)

CTGGTGCTTTCGGCCTCGCTGCGGTGCCGACAGTCCGTTCATGCCTCGCGTTTGAGGGCAG GGGGTGGCTCAGCGGCTGGCTCGCAGCTTTCTCCGCTGGCTGAGGCCCGCCACAGCCGAC ATGGGCTGTTTCTGCGCGGTTCCGGAAGAATTCTATTGCGAAGATTTGCTTCTGAATGAAT CCAAGTTAACTCTCACCACCCANCAAACAGGCATCAGAAAATCACGAAAGGGCTCATTGT CCTTGAGCACCGTATCCGCCACTCAACCCTGGGGAGGTGAGTATTTTTGGCTTGC

>'000203a-073.scf came from CONTIG 63 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-073.scf(l>639)

CGGGGCGCCCTCTAAACTATGGATCCCCGGGCTGCAGGCCCAGTTTCCCTCCCAGAACATT CTTGGGACCAGCCACCTTTCCCCAGGTGTGTGCTGCCCACTGCCACCCAGAGGTGGGATG

GCAGGTTCCAGGTTCCCTCTTGGATCCCAGGCTTCCCCTGACATCAGCACCATTCAGTGGT TTTCCTGGCTCCATCGCTATCGCTTCATGCTGAATGGACAGGACTGTTGACCTGTCTCAAG AAGCCCATAAGATTTGAGCAGAAACGNTGACTTCCTTGTACCTCTGCCAGAGCAGCTCCCT TCTCCCCCCCAGAATTTCACCAGATCTCTTCATGCTGCTCTTNATTTNCGTACTTGAAGTGG NTCTGCCGACAAACAGCAGACTTTGTGTGTCCCACTCTGACTTGCAGGACGGNAGNTTCTT

TCTCTTAAGTTGATCGCTTCTTGCTGTGACTGNCCCGCTGGNGAAAATGGTTTTGCCTCGTT TTAAGTGAACAGGAGACTAGATGCTGTACTAAACAGATGGAACCGAGAGAAACACTACC ATCAGTAAAGACCACCACCCAACACTCATAAACGCTAACAAATCTGCTGAAAGATGTAGC TGGAAAAAAAAAACGGGGGCCGGCCACCTTA

>'000203a-074.scf came from CONTIG 64 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-074.scf(l>580)

GCGGGCGCGCTCTAAACATGGATCCCCGGGCTGCAGGTTCCTGTGTCGTCTTGGAGGTGA CTCGGCGTGATTGAATTTGCGGCATCTTCGCATTCACTCACAGGTCAAAATGCAGATCTTC GTGAAAACCCTGACCGGCAAGACCATCACCCTGGAGGTGGAGCCCAGTGACACCATCGAG

AACGTGAAGGCCAAGAATCCAGATAAGGAAGGCATTCCCCCTGACCAGCAGAGGCTCATC TTTGCCGGCAAGCAGCTGGAAGATGGCCGCACTCTNTCTGATTACAACATNCAAAAGAGT CGACCCTGCACCTGGNCCTNCGTCTGAGGGGGGNATGCANAATTTCGGAAACCCNNTGAC GCAGACATCACCTGGAAGGGAGCCCANGACACCACGANAACGGAAGCCNAAATCAGATA GAGGCATNNCCCCGACACAAGCTCATCTTGCGCAGCACTGGAGAGGCGCCTCTTTGATAC

ACANCAAAAGGCGACTGCCCGGCCTCGCGAGGGGGAGCAATCTCGAAACCGACGCAGAC ATACTGAGGGGGCAGCACACCAAAGAAGCAAACAAAAAAGA

>'000203a-076.scf came from CONTIG 65 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-076.scf(45>598)

GCACGAGGCCTTCATCCAGCACCTTCCCCTGAGTGAGCGCATCCGGGGCACCGTCGGACC AAAGAGCAAGGCAGAGTGTGAGATTCTAATGATGGTGGGCCTGCCCGCTGCTGGCAAAAC CACGTGGGCCATCAAACATGCAGCCTCCAACCCCTCCAAGAAGTACAACATCCTGNGTAC CAATGCCATCATGGATAAGATGCGGGTAATGGGCCTACGCCGTCAGCGAAACTACGCCGG CCGCTGGGACGTCCTGATCCCAGCAGCCACTCAGTGCCTCAACCGTCTCATCCAGATTGCT

GCCCGCAAGAAGCGCAACTATATCCTANATCAGACAAATGTTTATGGGTCAGCCCAGAGA CGAAAAATGAGACCATTTGAAGGCTTTCAGCGCAAAGTATTGTATTTGTNCCNACTGATG AGACTGNAAGACGAACAATAAGCGACTGACGAGAAGGAAGGAGTCCNANACACGCGTCT TAAAATGAAAGCACTTCACGTGCCGATGTGGGACTTCTGGAGAGNGCTGTCATGAGCTGC AGGAAAGGAGCGAC

>'000203a-077.scf came from CONTIG 66 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-077.scf(46>306)

CACGAGGGGAATCTTGTCCTTCCAGGTCCGCCAGTTTAAGCGCCTTTATGAACATATTAAA AATGACAAGTACCTTGTGGGCCAGCGCCTCGTGAACTATGAACGGAAATCCGGCAAACAA GGCACATCACCACCACCTCCACAGTCGTCCCAAGAATAAAGTGGTTGTCTCCACTACCTTG GCCTTCCCCTTGCCTTCACGTGTCCTTTTTTGTGGACTTCTCTCTCTGGAGATTTCCCCAGT GATCTCTCAGCGTTGTT

>'000203a-078.scf came from CONTIG 67 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-;078.scf(39>281) CTAGTCTGAGTTTTTTTTTTTTTTTTTTT^ GTGGGTTTTTGAGAATGAATGTGCAGAGTTTATGATGTGTGTCAAGCATGCCTCGATAGCC

ACAGGCTTTACAAAAATTACCTATTGTTTGCTTCTTTGGATTGACATGCAAATCTGTTTCAT GATTCTCACACTCACGACAGAAAACAAATTTTTTTATGAATCCATCCACCATGCTT

>'000203a-079.scf came from CONTIG 68 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-079.scf(16>24)

ACAGGGATC

>'000203a-080.scf came from CONTIG 69 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-080.scf(38>623) NAATTCGGCACGAGGCAAGCGCCTGCTGGAGCCCCCGTGCTCCTTGCACTTGAACTCTATG

GGGTTTGGTGGGCAGAGGCTCAGGAGTCCCCTGGATTTCCCCAGCTGGTATCCTGGGACG TGGTAAGCCTTGGGGCTGGGGTAGCATGGGATCCCCCGAGGACCCANATTCTGGTACTNA GGGCAAGGNGAGGNGAACCCGNACCTCANCCGTCCCCCAGTCTACAGCCTGAGCCCAGTG TGCTCCCAGCTCCCCANTCCNCATGAAGCCTGCCGGNGGCTGGCAGNAGGGNTTAGAGGN NCTGGCCTTCGATTCCTTTTCTGTCGCGCTGCTTTCACCCGCTTCCTGCAGCTTTGCTCTGG

CCTGATGATCGTGCTTTGTTCTCTGTACTGTTAACTGAGCATGCCACATTTGTTGAAATGTT GTTCAAGTGTAAGCAAGGAGAGGTCCAATTGTGATGGGGATGGAGGCATGGACTCTGCTT CTATCCTTCTACTTATCTGAAATGTTGCTTCTGCTGTTGGATTATTATACAGGGCAACCTAT ACAGCGAAAAAAAAAGGCAAAAAATTCTCTACCACGAGA

>'000203a-081.scf came from CONTIG 70 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-081.scf(41>563)

CTCCAGTTACCTCTGCCAGTACCGCTGTGTCAACGAGCCGGGCCGCTTCTCCTGCCACTGT CCACAGGGCTATCAGCTGCTGGCCACGCGCCTGTGCCAAGACATTGACGAGTGTGAGTCG GGTGCGCACCAGTGCTCTGAGGCCCAGACTTGTGTCAACTTCCACGGNGGCTACCGCTGT

GTGGACACCAACCGCTGTGTGGAGCCTTACGTCCNAGTGTCCGACAATCGCTGTCTCTGTC CGGCCTCAACCCCCTGTGCCGGGAGCAGCCCTCATCATCGTGCACCGTATATGAGCATCAC CTCGAGCGGAGCGTACCGCGGACGTNGTTNCAATCAANCANCNNTCGTCTACCTGTGCTA CATGCTTTCAATCGTGCTGTAACTCGCAGGAACTCTACATAGCAATCACATGCACGCTGCT GTCTCGCTCGGCTGGACGGCCCCGGATACGGCTGACTGAGAGTCACTTACTCTCTGATACG

GCACTCTTTTGAATACGCTTGGGGCTACTTTGGGGGGG

>'000203a-082.scf came from CONTIG 71 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-082.scf(48>533) GCACGAGGGCCTGCTGCAGCCCGGCTGCCAGCTGGAGTCCCTGTGGGTGAAGTCCTGCGG

GTTTACGGCCGCCTGCTGCCAGCACTTCAGCTCTATGCTGACCCAGAACAAGCATCTCTTG GAGCTGCAGCTGAGCAGCAACCCGCTGGGCGACGCGGGCGTCCACGTGCTGTGCCAGGCC CTGGGGCCAGCCGGCACTGTGCTGCGGGTGCTCTGGGTGGGCGACTGTGAGCTGACGAAC AGCAGCTGTGGCGGCCTGGCCCTCACTCTGCTGGCCCAGCCCCACCTGCGGNAGCTGGAC CTGANNCATACGGNCTGGGCGACCCCCGCGTCTGCAGCTGCTGGGGCAGCTGGAGCACCC

GCTGCAGCTGGAGCACTGTCCTGTCGACTCTATGGACCGAGCATGGACGACGCTGCGGCT GTGGAGAAAGCAGCTGGNCTGCGATCTTTCTGACCCGTCCCCAGNGCGTNATGAAAAGTN CATCA >'000203a-084.scf came from CONTIG 72 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-084.scf(47>388)

GCACGAGGCACAGTAGCATCACTTCAGAAAGGAGCCAGACTTATTCTCAAAGAACTATGT TCACACTTTTCAGCAGAAATAGCGATGGTTGTAACATATGTATCCCCTCCCTCGGATTTGA AGGCACAATCTACAGTGTTTCTTCGCTTCTTTTCTGATCTGGGGCATGAAAAACCAAGATT

GAGATTTGAACTATGAGTCTCCTGCATGGCAACATAATGTGTGTCACCGTCAGGCCAAAC AGCCAGCCCTGAACGGTGGNTTTATTACTTGTGTATTTGTGTTGGATGATAAACACTCATC ATCTCTCCTGTAGTCCCTGCTCATTTCACTTAACCCTAN >'000203a-085.scf came from CONTIG 73 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-085.scf(9>658)

CGCTCTATACTAGGGATCCCCGGGCTGCAGAATTGGCACGAGGGGAGCTCCGCATCCACA CCGGCCAGCCCAGATCCCGAGGTCTGACAGCGCCCGGCCCAGATCCACAAGCCTGCCAGG AGCCAGCCGAGAGCCAGCCGGCCGCGCGCTCCTACCCCAGCAGTCTCTGTCCTTCGGCCT GAGCCCCGCGTCCTTCCCGGGACCTCTGCCCCTCGGGCAGTGCTGCCACCCTGCCGGCCAT

GGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGNGCGCAGGCCAGCTCCACCCCGCT GCCACCCACCCGCATCACCCGGCTGCAGGAGAAGAAGACCTACAGGAGCTCAATGACCG NCTGGCTGTCTACATCGACCGTGTGCGGGCGCTGGAAACGAAATGCAGTCTGCGCCTCGC ACACTGATCTGAGAGGGGGCAGCCGGAGGGTCTGGCTTAAGCCCGCTCCAGCCGACTGGG GAGCCGCCAGACCTGACCGTGGNCAGACGCGCCGCGCGCGGACGACAAGGGAAGAGTCA

GGACCAGCACGCATCAAAGAGGAACGAGGCCCAGCCGCTAGACGAGGCGTCACCAGAGC GGCGGCTGTTAGAAGCCGGGGGACGGACGGGGAGGCATGGGCCCGGGGCAAC

GCACGAGGATGAATTTTCACTGGCCCTTCGGCATCTGGTTGTGCAAAGCCAATTCCTTCAT TGCCCAGTTGAACATGTTTGCCAGTGTCTTCTTCCTGATGGTGATAAGCCTGGACCGCTAT ATCTACTTGATCCACCCGGTCTTATCTCATCGGTACCGTACCCTCAGGAACTCTCTGATTGT TATTATAGTTGTTTGGCTTTTGGCTTCACTAATGGGTGGGCCAGCTCTGTACTTCCGGGAC ACTCTGGAGTTGAATAACCACACTCTTTGCTATAACAACTTCCATGAGCATGATGTGGACC

TCAGGTTGNTGAGGCATCATGTTCTGACCTGGGAGAAAGTTATTGTTGGGTACCCTCTCCC TCTGCTAACAAGAGCATTTGCTACTTGGCCTCATCTCAAGAGAAGAACGAGCACCTGTACT CAGAAGCCTCCTGACCACCCGGCGNGGNCATGCCTTNCGATTGCTGAATCCTATCACTGTT ACATTGGAACCACGACCACACATACTATTCACCAAGCTACAGCACACCCCTTCACGCCGN GTTCTCAAATGCTGACCCCCCTTACCCGATATAAAAG

>'000203a-087.scf came from CONTIG 75 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-087.scf(46>645)

GCACGAGGATTTAATATTGTGGAGGGTGGGGCTTCCAGGTGAATACAGTTGCTGGTTGCT GAGCCATGCCCAACTCTTTGCAACCCCATGGACTGCAGACCGCCAGGCTCCTCTGTCCATG

GAATTGTCCAGGCAAGAATACTAGAGTGTGTTGCCACTCTCTTCTCCAGGGTATCTTCCGA ATATAGGGATCAAACCTGGATCCCCTGGATTGCAGGCAGATTCTTTATCCTCTGAGCCACC AGGGAAGCTCCTAGTCACCCTAAAACCTCCAAATTCTTAAAAAAATTACCCTATCTACTTC CACCCCAGTCTTTCTCTCTTCTTCTTTTGGTGTCTTGATTTTTGCTTTTGGCTCTGCCACTGC ATCACATCACCTCTTCCAGCCTGACTATGAGTCGCCTCAGACTCAGAGCAGTTCACTCACG

AATCTTGGCTTGACCACATACTCTCGNACTTGGCTCTGACTGCTTTTTTTATTGTTATTCGA CATCTCCACCCGCGAGATCTCTTTGGACAGCCTTGTATAACATCTGTTATACCTTTTGTACG CTATTTGGGAAAAATAATTAAAAGGGGCTCCCCCAAAAAATTACGCAA >'000203a-088.scf came from CONTIG 76 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-088.scf(19>21) TAT

>'000203a-089.scf came from CONTIG 77 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-089.scf(l>428)

AGGTGGCGGCGCTCTTATTATGGATCCCCCGGGCTGCAGAATTCGCACGAGGGAGGCCTT TCGGCCGCAGCCATGGCGCCCAGCCGGAATGGCATGATCCTGAAGCCCCACTTCCACAAG GACTGGCAGCGGCGCGTGGCCACGTGGTTCAACCAGCCGGCTCGCAAGATCCGTAGACGC AAGGCCCGGCAGGCCAAGGCGCGCCGCATTGCCCCACGCCCCGCGTCCGGTCCTCTCCGG CCGGTGGTGAGATGCCCGACGGGTCAGTACCACACGAAGGTTCGTGCCGGCAGGGGCTTC AGCCTGGAGGAGCTAAGGGTGGCCGGCATCCACAAGAAGGTGCCCGGACCATTGNNGAT CTCGTGGACCCGNAGCGCGGANCAAGTGCACGGAGTCCCTGCAGGCCACGTGCAGCGCTC AAGGAGTAN

>'000203a-090.scf came from CONTIG 78 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-090.scf(42>591)

NAATTCGGCACGAGGGGAAGTGTATAATTTCCTGGCCACTGCAGGTGCCAAGTACGGCGT GGGCTTCTGGAGGCCTGGCTCTGGAATCATTCACCAGATCATTCTGGAAAACTATGCGTAC CCTGGGGTTCTTCTGATTGGCACTGATTCCCACACCCCTAATGGCGGTGGCCTGAGAGGCA

TCTGCATTGTAGTCGGAGGTGCTGATGCCGGGNACGTCATGACTGGGATCCCCTGGGAGT TGAAAGGGCCCCAGGTGATTGGGCGTGAAGCTGACAGGCTCCCTCTCTGGCTGGACCTCA CCTAAGATGTGATCCTGAAGGTGCGGGTATCCTCACAGTGAAAGGTGGCACGGGCGCCAT CGGGNAGTACCACGGGCCTGGAGTAACTCCATCTCTGCCCCGCATGCGACCTCTGCACAT GGTGCAGAATCGGCCACACTTGTGTTCCCTACACACAGAGAANAATACTGACAGACGGCG

GCAATATGCACCTGTGAGATTAAGATACTGTACTGCTTGCTGCCTTTACAATTATATTACC TAGGCGA

>'000203a-091.scf came from CONTIG 79 at offset 0; "E:\SEQUENCE\export\EST_db\000203a\000203a-091.scf (41>338)

TAATTCGGCACGAGGCCCCTTTCATCACCAACCCTGGGTATGACACTGGAAACGGTATTCA TCTTCCCGGCACTTCTGGGCAGCAGCCCAGTCTTGGGCAACAAATGATCTTTGAGGAACAT GGTTTTAGGCGAACCACACCGCCCACCACGGCCACCCNCGTAAGGCATAAGCCAAGACCG TATCCGCCGAATGTAAATGAGGAGATCCAAATTGTTCATGTCCCCAGAGGAGACGTAGAC CATCATCTCTACCCTCACGTTGTGGGACTCAATCCAAATGCTTCTACAGGCCAAGA

>'000203a-092.scf came from CONTIG 80 at offset '

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-092.scf(47>391)

GCACGAGGCAGCCCGAGGACAGCCAGCAGGACCTGCCTGGGGAGCGCCACGCCCTCCTG GAGGAAGAGAACCGGGTGTGGCACCTGGTGCGGCCCACGGACGAGGTGGACGAAGGCAA

GTCCAAGTGCGGCAGCGTGAAGGAGAAGGAGCGTACCAAGGCCATCACCGAGATCTACC TGACCCGCCTGCTGTCCGTCAAGGGCACGCTGCAGCAGTTCGTGGACAACTTCTTTCANNA GCGTGCTGCGCCCGGGAAACGCGTGCCACCGGGCGTCAAGTACTTCTTCGATTTTNCTGNA CGAGCAGCAGAAAAGCATGACATTANAGATGNANGACACCNATTNC

>'000203a-093.scf came from CONTIG 81 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-093.scf(44>356)

CAAAAACCAGAAGTGACGGGAGGTGCTGCGCTCCCCTGCGTCGTGGCAAAGTCAGCTGGC CTCTTGTGTGTGCGTGTGTGCGTGTGAGGAGCCGAGTGTGGGTGTGTGGCGGGCGTGGGA GCAGCTTTCTCACATAGTGCCTTATACACGCTCTAAAGAAACCAGTCTTACATGTTAAGAA

CAACCAGTGTTACATTTTCTACACTACCTTNCATTTCAGTAGCTTTGATGACCAGTTTTGCA GTTCATGGAGGAAATCATGGNNGCGTCCCAAGGGGCTCCCCATGCCCGAGAGCCGACTGG TCNTGTGACG >'000203a-094.scf came from CONTIG 82 at offset

0;"E:\SEQUENCE\export\EST_db\000203a\000203a-094.scf(40>373)

GGGTTTTTTTTTTTTTTTT^

CCAGCCACAAGTGTCTTCAAAAATTAACAAAACAAAAAAAATATATATATGGCCATAGTT

CACAGTTAAGCAGCCAAAAGCTGCTCCAATTATAGCCTTTAAACAACATGTGAGCATCCT CCCTTTCCCTCCCCTTCAGTAAGTATATTCACAGCTTCAAGTCCTCTGTCCGAAGCACTCTC

CACAGAGAGAAGTTAAGAGTCAATGCACCTTTCTGCAAAATTGTCTGAAAAGCTTTANNA

AACAGTACGTCAAGGAAACTGCTTCGGNTC

>'000203a-095.scf came from CONTIG 83 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-095.scf(42>489)

CGACAGCCTAGAGGGCTTCGTGCTGTGTCACTCCATCGCTGGGGGAACAGGCTCTGGCCT GGGCTCCTACCTCTTAGAACGGCTCAACGACAGGTACCCCAAGAAGCTGGTGCAGACATA CTCAGTGTTTCCCAACCAGGATGAGATGAGCGATGTGGTGGTCCAGCCCTACAACTCACT GCTCACGCTCTAGAGGCTGACCCANAACGCCGACTGTGTGGTGGTGCTGGACAACACTGC CCTGAACCGGATCGCCACAGACCGCCTGCACATCCAGAATCCCTCATTCTCCCANATCAAC CAGCTGGTGTCCACCATCATGTCAGCCAGCACCACACCCTGCGCTACCCCGGCTACATGA AACACGACCTCATCGGCCTCATCGCCTCGCTTATTCCACGCCACGCTNCACTTNCTCTGAC TGTTTCACCCCCTCCACAGNACAGCG

>'000203a-096.scf came from CONTIG 84 at offset 0;"E:\SEQUENCE\export\EST_db\000203a\000203a-096.scf(43>460)

CATCAGGCTCGAGGGCTCTGTTGTGCGGACTGCTCCCCCTGGACCCTCTGGTTTCTCTGGG CCCTCTGACCTCTTTGATCCTGCTGGTAAAGAAGGGCTTCGTGGGCCTCGTGGGGACCAAG GTCCAGTTGGTCGAAGTGGAGAGACAGGTGCCTCTGGCCCTCCTGGCTTTGTTGGTGAGA

AGGGTCCCTCTGGAGAGCCTGGTACTGCTGGGCCCTCTGGGACCCCAGCCCACAAGGCCT TTTTGTNGCTCCTGTTTTTCTGGGTCTCCCAGCTCTACAGTGAGCGCGACTACACGTGTCGT GATCTGTGGAGGGGTTGACACCTCTTTTCCTCGTTACATATAAAAATGTAAACCTGCCTTA ACTGGACATATGACCTGATACTCACTTATATTTTTTCTGGCTTTCTTAACAAA

>'990729A-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-001.scf(56>557)

GCACGAGGGGTGGTTTTGCTGTGTTAGCAGCAATGTCAATACAAGGTTCTGCAAATTTACA AACCCAATGGAATATTGTTGGGGGAATTCAACAATTTGCCACAAGAAGAACTTATTGAAT GGATTAAATATAATACTAAACCGGATGCAGGGTTTGCGGGTGCCATGCCCACAATGGCAA

GTGTTAAACCTCTCCGCACTCGGGCCGTTGTGAATCATCCACATTATGAAGATGCGGGTTT AAGAGCCAGAACAAAATAGTATTTCGATGATAAACGGAAGCAGTGAGAAAGGAGGAGAC TGTAAAGTACAGTGAATTTTCATTTGGAGAATGGGGGTAAAAAATACAAGCGGATGCAGA GCGGAATTGGGATGGGAAACCTGTATGCGGAAATCCCTTTCAACCTTTAAGAGGCAAACC CCTCCCCGATTCCAACAAGGACAAAACTAAAAATAGAGGACGCGCTCAAAAACCCAAAG

GGTTCTTTGTTTAACTGCTGTT

>'990729A-008.scf came from CONTIG 2 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-008.scf(315>902) GAGGTTGGGGTGTGGTGTTGGGTGGGTAGGTGGTTGTGTTATGTGTGTTGTGGTGTGGTGT

TGTTGTTGGTGGGTGTTGGTTGTGGTGTGAGCTTGTGGTTGTGTCGGTGTTGTGTGGTGTTC

TGGTCTGTGTTGTCGTCTTGTTGTTTCTTTGTTTTGTTTTTCTTTGTTCGCTGTTTGTGGTCGT

CTGTATTCTCTTTCTCTCATGTTTGTTTCGTTCGTTTTCTTATTTCTTTATGTCTT

AATCTTTTTTTATTTTTTTCATTTTTATATTCTATTCCT^^ CTTTCCTTTTTTTTTTTTCTTTGTTTTTTTGTT^

ATATATTCTTACGTACTACTACATCTTTTCCTTC^

TTGTTTATCTCTTCACTTTTCTTTTTCTCTTTTTTTTATTπ

AATAATTTATTTAAT

>'990729A-028.scf came from CONTIG 2 at offset 149;"E:\SEQUENCE\export\EST_db\990729a\990729A-028.scf(291>388)

TTTTTCTTTTTTTTTTTTTTTAT^

>'990729A-012.scf came from CONTIG 2 at offset 234;"E:\SEQUENCE\export\EST_db\990729a\990729A-012.scf(576>659) TTATATTTCTTTTATTCATCTTTTTTATTATTTCATT^ TATTTCTTTTAATCCTCTT

>'990729A-002.scf came from CONTIG 2 at offset

430;"E:\SEQUENCE\export\EST_db\990729a\990729A-002.scf(249>314)

ATTCTATTTCTTTTTTATATCTC^

T

>'990729A-003.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-003.scf(48>272)

TTGGAATTAGGAACGAGGGGGGGGCTGATTCCGCAGGACGCCGCCGTCGGGGCCTTCGTA TTGGTGGTGGCGAGAGGGCCGGCCGCCGAGGACAGGCCGTGGCGGGTCGAGGCACTCCC CAGGAGAGCAACATTCATAGGGTGGGTTGGATAGACGGGGTACCCGGCCCTGACCGATAT ACATGGCCGTTGTGGGACATTATTTCACTGTTGGAGGGCCCTTCCA

>'990729A-004.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-004.scf(62>70)

TΓΓΠTTTT

>'990729A-005.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-005.scf(51>589) CTGCCAAGGAGGGCAAGACATACAGGTGGTAAGGTGATGCCCGCTGTACCTTCTTCACCA

AGGTCCGGAGATGACAGATACCACTCCAAGAGCGCACACAGGAGGGCCAAAGCCCCACA AGTGGCCCGCACTGCGTCCAAGAGCCTTTGCGCAACGCGCTCCTCACCTGGGCCCAGCAC CCTGCGCATCCACCTAGGCGTGCAAGCCCTACCACTGGGTCCTACTGTGATAAGAGCCTTT CGACAGCTCTCCCACCTCCAACAGCACACCAAAAANCACACAAGCGACAAACCCTCAAGG GCCCACATCTGGGGTGGAATGGGTTCACTCAATCTCCACCCCCAACCACCACGCCAGGCA

AAAGGGCAAGCTCAAGGGCCCACTGCTCCGGGCCCCCGGCCCGCCCCTGCGACCCCCCTC GCCATGCCTCACCGCCAGCCGCTGTGGGGAGGGGGGGGCGCCCCCGGACTACTATGAGAA TACAACACAGGGGGGGCGGGGGCACTGCCCCAGGAGAGCCCCATCGGGGATTTTTTGGG >'990729A-006.scf came from CONTIG 6 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-006.scf(57>631)

GCACGAGGGTTTCCTGGCATCCTCAGGTGTACTGGNGATCCTGTGTCTATATTGCTCCCTC ACTGAAACTTCCAATAGCTGCCCTGTAGGCTGCAAACTCAGATGCCCGTGTGGGCAAGTG ATGGAGATCAGTGAATATCTGGGTACTAAAAAAAAAAAGCACCATAAAAACTAGACAGG GTΓTTTTAAAGAAACTAGACAGGGGTTTTTAAAAACTGGAAAGAGCATGTTCCCTGGCCT

AGCCTCCATTTCCATGAAGGAGTAAAGGCCATCCTGACCTCAGGTAGTGAACAATCTATG TGCCTGACACACAGGTGCTGGGGCGAGGCTGNGAGTGAGAGAAAGGCCCCTCCTCTCCTG GGTGGATGCCAGATCTACAGACCTGAGCCCACAGGAGCCACACCAGGGCAAGNAATACT GAAACATCTGCAAGACCAGATGTCAGNNTGTTTTAAGAAAGCCTGAATCAGATTTTCTGT GAATTCATTTTTGCAATGGGATTACAGCAGAAATCCACTTTTTATGATTATGTTAGTGGAA

TCTAAAAAAAAAAAAACTGAGGGGCCCGACCTATN

>'990729A-007.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-007.scf(57>619) GCACGAGGCTAAAGCCATGCCTCCTCCTGCAGAACCAGATTCTCTCTCTTTGACCTTCCCC

CTCCTGTTTTCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGGGTCAAGGT GCTAATATAGACTTAAACGAATACATTAACGGAGCTAAACACAGACATTTTAACCCAAGT CACGACATTCTTAGCTGTAACTCAGCTCTCACGGCCTCTTGCTCACCCATGAATGGTCCCG TTTTCCTCTTGCCGCGTGCACCTCCACCCATTGTCTTGGGGGCACATGGGTGGAACACTTG ATCTGCTCGCGTCTGCCTTCAACACACATTGCATCTTCAGATTTTCTACTTTTCTGTGTCAA

AACTAAATTCACCAAGTCAGACTTTGTGTTAATTTATATCAGGGGATGGGCTGNCAGGGG GCATGCCTAGNGGCCCCGAGAGGACAAGGGGAGAACAGCACGGATGTGGCAGGTGCTCT AGGCTGAGATCAGGGGGAGAGACGCGATCACAGCAGACGCGATACGATCTTGTCGGGCG GACGCACAGAACGAGCGN

>'990729A-009.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-009.scf(50>328)

TGAAAACTTCGCTGTTCTATGCTTGGATCTTTGGGAGGGTCAAGTCTGGGCACCATACTTT GACAATCTTCCTCATCACCAACGATGGAAGCGGATGCTGGGGGAGTTTGGCAACGGGACG TGGGNGTGTTACAAAGGCAGCAGAAAAGCAAATGAAGGACAAGCAGGGAGAAGAGCAA

AGGCTACATGGAGGGAGGAGGAGGAGAAAAAAGGCGAGGGAGAGGAAGAGGCAGACAA AGATGATACGAAGACAAGGATGAGGATGAGAGATAGAGAGAA

>'990729A-010.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-010.scf(56>610)

GCACGAGGGTTTATTGTTGCATTCTCCCTTAGCGTTGTCCTGCTCAGGGTCAGGGCCTAGC TACAGATTGGGCTTCCAGAATTGTAATAACTGTTTTTTAAAGTCAGACCTTGGCAAGAACT ACAATAATTTGGGGTTACATGCCCTTGACTTTTTAATAAACATCTCTTTCTAAGGAGATGC AGAAGGAAAGGAGGGTCTAAGCGAGACTCTGGCCTACCTATAATAATGTCTGGGAAACA GGCTAAACTTAAGGCCATGGTCCACTCTTACTTCAGAGAGGGAGCTCAGATTGTGACATT

ACTGTTTCCTTTCTGGCCITTTCTCCTGGATAGAAGGAAGAATTGGAAATAGTTTGAGTAG

TGGTTGGTTCATATTACCTCCTCTTGGTTGTGTTATTTTTTTTTGCCCCCCCATATTAGGCAG

GGCCCCCTGATGAGATGAGGGGGCTAGGCTACAGNGCCTGAGGGAAGACTATTTGGTTGA GGAGAGATCTCCTACAAAGNGAGGGGTAGAACCTCCTTCTACTATCTCTTACACAGATCG

TCTATCCCA

>'990729A-011.scf came from CONTIG 10 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-011.scf (46>647) TAGGAATTTTTTTTTTTTTTTTTATCAAACAAA^

AAATACAGCAAGCCAGTACACAGTTTCAGGACACTGCTTTAAGTACAATGAAAACTTGAT ATACAAAAATGAAAGAGGAAATAGCAGAAATAAAGCTCGATTTTTTTAAAAAGTTGAAGT AACCTGAAAACCTTTAGACTAAAAGAGTCTTACATCAATTCATAAATGCCTTAATTTATAG ATAACAGTGGTACATTGTAATCAAAAAGGACTTCCCAAAGAGTCATTTCGAACTGATCAG CTCCAGATAAGAAATTCCTGGCAGTGGCTACTCTGGGATTCGGCACTCACTCATACTGTAC

AGACTGGTATAGTTCAATCCATGGCATTTGATTTTTATTCAAATTCCAANAAGGTAAATAC CTTTTTGGTAAGNTCAATAGGAGGCCCACACCACTACCAAAGAGTCCTGAAAATGCCACT ATATATTAAAGGTCTAAGACCATTTTGGCTTAGGCCCATGTACAATGTGGGGAAAGACTC ATNANACTCGTACTTAAATCTTTGTAGATGCAAAGGCCCTAAGCTNCCAGAAACGNT

>'990729A-013.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-013.scf(55>549)

GCACGAGGTGAAAGGTTAATGGTTTGGCACATAGTTATTTGCATTTTAAAATCTCTGGTGG GGTGGTGGATGTTTAGGTGTGGGATTTAGGGGACAAGGAACCGGTTTCTTAGCTAAAGTG TTCAAGTACTGTTTTGAACAGCTTATTCATTTTTGCCAGCCCTTCTGGACATCCCACACCCA

CCCATCTTTGCTAGGCTTAAAAGACTGAGCTATCCCCAGTGGCTGGCTGGCCTTGGGATTG GCTGCAACCTTGTTAGAACCACACAGGTTCCATCCTCACCTAGCCGCCTGTTACTTCAGGC GAGGGGACAAAGACCGCCGCAGGACAGAGTAAAAGACTCAGCTTCAGGACCCTTGGTTC CCCTTACCTAAACCCTAATCTACCCCTTCTTTTTCCTGGAGACTTTCACACTCTTTTTTAGA GCGACACCAATATAAGCTCTATGCTAAAGGAGAGAAAGAGGCTGGGCGACTTTATTCCCA

CCAACAGTA

>'990729A-014.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-014.scf(49>564) TGCTGCGGCAGCCACAAGAGGGCTCGGGCCTGGGAGCATCCCTGAATGAGAGCAGCCTGC

AGGACATCATTCTGGAAACAGTGCCCGGGGGAGCCAGGACCCCAGGAGGAGGCTGAAGA GGAAGGTGGGGGCGGTGAGGGCATAGCCCTCCCGGCCTCTCAGGGCACGTCGAGCCCTAT CATCCACGTCGTGAACCAGACCAACGCCCAGGGCGAGCGGGAGGTTCGTCTATTACGTGC TGTTCGAAGCCCCGGGAGAGCCCCCACCCGCCTCTGAGCCCCCCTCGGGGGCGTCATGGG AGAGCTTCAGGAGCAGCGGAAGACCAGAAGTCCAGATGGTGTGAAGCTGCAGGCCCCAC

CCTTGTACCNCAGCCTGGAGCTGAGCCGCTGTGGCAGCGCCTAGGGCAGCCTGTCACGAT GCTTAGAGGAGCTGGAGACGGTGCACCTGAGCATGCGCACTACAGCGAGACGTCTTTTGC ATCACTCTTGTGGCGAAGTTGTTTGAGGGGACCGNGGG >'990729A-015.scf came from CONTIG 13 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-015.scf(47>430)

TCGAGTΓΓTTTTTTTTTTTTTTTT^

AAACCCTGCTCACCTGCTTCATCCCCTTTCCTGCTTGGGAGGGAGGGCTCCTTGGTATGCA GAGCCACAAAGTGGGCGATCCAAGGGGAGATGCTCCTGGTGACTTCCCCACGGACCTTGC TACTGGCCTTGGCTCCTCACTGGTAGTCGGCACCTTGGACTCAAACCTCATCTGCCCTTGG

TCTTGCCTACTGGCAACTCTGGTTAGAGGGCTTGGCCCAGCTGCTGGCCCTTTCACCCCAG AAGTCTGTGCAGCCTTGTGCCCAGCCAGGCCTACTTGAGCACAAGCATGGCCTCCGTGCC GTCCTTGGCGNGCAGGTAG >'990729A-020.scf came from CONTIG 14 at offset

0;Ε:\SEQUENCE\export\EST_db\990729a\990729A-020.scf(362>694)

TTGGTGTTTTGAGTTCGTGTGTCTCTCTΠ^ TTTTTTTTTTTTTTTTTTC

TTTCTTTTTTTT CT^ TTTTTTATTTTTCACTTTTTTTCTAATTCCACπ^

ATAATGCTTCTCCATAGACTCATTAATGTCTAACTAGGATGAATATAATTCTCACCCATCT

TTTCCTCCGA >'990729A-031.scf came from CONTIG 14 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-031.scf (45>126)

TTGGGTTTTTTTTTTTTTTTTTTT^^

TTTTTTTTTTTATGG >'990729A-016.scf came from CONTIG 14 at offset

83;"E:\SEQUENCE\export\EST_db\990729a\990729A-016.scf(443>608)

CTTTTCTTTTTTTTCTATTTCTTTTTCTTTTAT^^ TTGCTTCTTTTCTTTTCTTGTTGTTTTTTTTTGT

>'990729A-017.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-017.scf(46>592)

TGGCTGGCTTCATGATTCCTTAAAAAGGCCCCCACCACAGAGGGAGGACAAGAAGGCGGC TGAGAAGAAACGGGGAGGACAAAGACCAAGAAGAAGCACGGACAGGGAAGTCCAGGCG CCCGGGACGAGGAGGAGGGAAGACAATGAGGGTGGCGAGTGGGAGAGAGTCCGAGGTG

GCGGGCCCCTCGTTAAGGAAAAGCCAAAAATGTGTTGCCAAGGGAACTGAGATCACCCAT GCTGTTGTCATCAAGAAACTGAATGAGATCCTACGGCACGAGGAAGAAAGGAACTGATCG TGCAGCCAGATGAGCTGTGGGCTGCGGGTCAGTTGCCTTGAAAACACCTAGAGAGGGCGC ATCGCAAGATAAGTTCACATCATTGCTTTTTTTACTACACCCCACCTGCTCGACATGAGAC GGAGTGCAGAAGAGTTGACTGCTCATGAGTGTGGCATCTGTTGCAACCTACTCTTGTGAG

AGAATATGGAAAGGAGACGCTACCAACACCCGGGTCGGCTGCTTTACTGGGACGAGTAGA TTCCAAAGCG

>'990729A-018.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-018.scf (55>562)

GCACGAGGGTTTGTGGAAAATAACTCCTTCACTTCAGCAAAATGTTGTCATGGAAAGGGT GTTGACTTCCGTGTCTGGAGACTTGATGAGTCTTGGTGCTATCAATTACAGTGTGAGTTTG GGCAAGGCACAGGTTGCCCTAGATTTATTGCTTCATTTCTAAAGAGAGGATTGTAATGCCT GACCTGCCTACCTCACAGGGCTATTGAGGGGATCCAGNGAGACAGGATACACGTAAATGT GATTTTGTAAGATGAAAAGTATTGGACGGGGGAAAGAATTTAAGCCATAGATTTTAGACT

ATTTTTCAAATGACTGAAAAAGAAATTTTAAGAATTGATTTCCTGGCTTACCAACCTCATA GAGAGAGACAATGAATTCAGCTGCTAAGGAAAAAACTTAGNAGTCTATGTTCTTGTCAAG GGCCCGTGCTCTGCGCGCTACATTTCTCCTCAGCAGCGACTGCCACACACTGCGAGGAGG GAAAAGAAGAGGNGACAAGATGAGA

>'990729A-019.scf came from CONTIG 17 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-019.scf(49>570)

GTGAGGATCTCGTCTCTGCGCCTTGAGCCATGCCGTCCAAGGCCCTCTGCAGTCGGTGCAA GTCTTCGGACGTAAGAAGACGGCCACAGCCGTGGCGCACTGCAAACGAGGTAACGGCCTC ATCAAGGTGAACGGACGACCCCTGGAGATGATCGAACCGCGCACGCTGCAATACAAGCTA

CTGGAACCTGTTCTGCTCCTGGGCAAGGAGCGATTTGCTGGTGTGGACATCCGCGTCCGAG GAAGGTGGTGGTCACGTCGCCCAGATTTACCCATCCGCCAGTCCATCTCCAAGCCTTGGTG CCTATTACCAGAATAGGGGATGAGGCTTGCAGAAGAGATCAAAGACTCCTATCCAGATGA CCGACCTGCTGTAGCCGATCCCGCGCTGCGATCAAAGTTGGAGGCCGNGCCCGGCCGCTC CAAAATCTCCGTAGCCGGCTGAAGCACGTNCCTTCACACTTTATAAGTTTGGATTAGTTTA

GAAAAAAAAAAAAAAAAAATGGGGGGCCGACCCATGCT

>'990729A-021.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-021.scf(46>562)

CACATACCGCAGACTTTACTCATTTAAAGAGTTAACAGTTCAGAGATTTTAAATATATTCA CAGAATTGACCATCACCACAGATTTTTAACATTTTCAACACCCCCAAAAGAAAGGCGCTA CCTTGTAGCAGTTACTCCTCAGATTTTCCCCAACCCCCCAACTACAGGCAACCACTAAACC ACATTCTGTGTCTGACTGGCCAACTGGGGACATGACTATAATGGGAGATTATGTGGCCGT GTGTGCGAACCAGCTCAGGGCTTAAGGAGCAGGAAGCAAAGGAAAGGCTGGATGTTGCC GCAGAGACGAAGCCGAGGCAGGAGCTCGGGTGGGGAGGCCAGGCAGAGGAGCAGGAGC GCGTCTCTACCAATCTNGCTCAGAGACAGTAGGCTGGGCGCGGCCCGGGCTTTCACCTCTC GCTATCAAGGCGGACACATCCACAAAAAACCGCG

>'990729A-022.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-022.scf(197>625)

ACTAGGGGAGAAAACGGGCACAACGCTGTAATAAGGCAATTGGGATGACTTTTATCCCCC CCCAAAAGGGGGGAAGGGGGGAGTCCGCCCCCCCGGGGAACGGGGAACAGAGGGAGGC AGCGGGGGGTCTCTGGTGGTGCTTTCGTGCCAGCACCCCCTATCCGGGCGCGGGGGTAAG

GGGAGTCCCCCCAGGAGACCCCAAAAAAAGAATTTTTTCTGAACCTTTAATTGGGCCTGTC TTTAATAATTGTGGGGGGGGGGGTTCTTTGCTCCACCACAAGAGACGGAGGGGGGATATG CTGGGGGGGGCCGGCAGAGGAGGTTGGCCCCCGGGGCAGACCTGCAAGGCGGGCGCGGC GCCGAGGAACAAAGCGGCCCGCCCCCCCTCCTGGCCGGGCCTCCCCCCGCCTGGGGGGGG GGGGGCCACGT

>'990729A-023.scf came from CONTIG 20 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-023.scf(48>557)

CGCGAGCCCCAGGACCTGTGTGCAGTAGCCGCGCATCCCGAGCCGGACCACGTCGGAGTT CCTCTGGACCCAAGACATCAGAAGCCATGTCGAAGCACCACAGCGACGCCGGGACGGCCT

TCATTCAGACTCAGCAGCTGCACGCAGCCATGGCCGACACATTCCTGGAGCACATGTGCC GCCTGGACATCGACTCACCGCCCATTACGGCCCGAAACACCGGCATCATCTGTACCATCG GCCCAGCTTCAGAGCAGTGGAGACATTGAAGGAGATGATTAAGTCTGGATGTATGTGCTC GTTGAACTTTCTCATGAACCACGGTACACGCAAGACCATAAGATGACGTGAGGCCGAGGC TTGCTCAACCCTTCTTTCGGCGGGCGGGCCTGACACTAGACGAGATCGACTGGTCACAGG

CGCGCCGTGGGGGGCGAGAGGAGCCACGAACACTGCAGCTACTGAAGGGCGACTCGGCG ACCAACATGAGGGGGGGCGAGATACGAGAGC

>'990729A-024.scf came from CONTIG 21 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-024.scf(101>231)

CGCGGGTTGGGTGTGCTGGTGGCTTGGTTTTTTCTGCTGATTGTCTTGCTGGTTGCAGTTGT CTTTGTCGTTGTGTTTGGTTTTTTGTATGTTGGTGTTGTTGTGTGGCTATTATGGTGTGTGTG GGTGTA >'990729A-025.scf came from CONTIG 22 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-025.scf(31>550)

GTCCCCCGGGCTGTTTGGTAGAACCTTTATTTTGTGGTGAATAATCCTATAATTGCTTGGA GTAATTTATTTTGTTTATTATTTTCTATTAAAAAATTGTCAGACCTTAAAAAAGAAA^ AGGTTTAAAGCATCATGTTGGCAAGTCATTTTTATGTGTGGGGGAATTTGGCAAATAAATT TTAGGGGGATTGTTCTTTTTTCCTTCTTGGACTTTTTATCAGGGAGAACATGTCAGGATAA

AATTTAAAACTAAATTCAAAATCATTTGGGGGCGGTGAAACAATGAATAATATAGGGTGG GGGGCTCTATTTTCTTATTTCTGTTGTATGACAGGACTGGATCGCTTTGTGTTTTTAAATAT TAAAAGATAGGGGGTTGCCACTTCTGGTGGTTGCTTTGGACTGTGGCCCGGGCAGCCGATT GGGGGAGGAGCAAAAAATGATACTATTTGTGTGGGGCAGGGCTGGTGGGACAGGAACAT TTTTGTGTGTGGGTGTTTATTTTTTTAGGGAGAG

>'990729A-026.scf came from CONTIG 23 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-026.scf(44>536)

TTTGTGAGTCTCATTTTAAGTGGCCTTGATATTTAAAACTATTCCTGCCACCAATTCTTTTC

CTGGGGTATGAGTTATTTAAAAATGAAAGGGGTAAACTAGTGGGGTTGTGGAGATTAACA TAAAGCACTGATTTAACTTGCTAAGTAAACTGAAAGATAAATCCTGACTGCCTACTATCCA ATGTCAGTTAACCGCGTCCTCCCCTTCATTTTCTCAGTCCCCTAAAGCTTCTGTCCCGGATT CCTTCATTTGCTCTTGACTTCACGTTGCTCTTCTCTTCTCCCGCTTTGCTCCTTCCTGTCTNC ATGAGTTGATGAAATGGAAGATTAATTGCATGCACTAGGTTGGAGGGGGTGNGGTNTGTC

TTTCTACTAAGGTATAGCCATCACTTCCTAGATAAATACTACCTAAATTGATGTCTCATTTG

>'990729A-030.scf came from CONTIG 23 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-030.scf(45>376) TTGGTGAGTGTCATTTTAAGTGGCCTTGATATTTAAAACTATTCCTGCCACCAATTCTTTTC CTTGGCCACTTTTTCCTCCTGTGTCTTGCTGCATGCTGGTTTATTTGCTTCCTCCCCACCACC CTGTGGAATGAGTTATTGAAAAAGGAAAGGGGTAAACTAGCGGGGTTGCGGAGATGAAC ATAAAGGACTGATGTAACTTGCTAAGAAAACTGAAAGATAAAACCTGACTGCCTACTATG CAACGGCAGTTAACCGCGTCCTCCCCTTCATTTGCTCAGGCCCCTAAAGCGCTGCCCCGGA

TTCCTTCTTTGCTCTTGACTTCACTTG

>'990729A-027.scf came from CONTIG 24 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-027.scf(54>547) GCACGAGGATCTTGCTGCTTATATGTACCTGTGCTTATATCCGATCCTTGGCACCCAGCCT

CCTGGACAGAAATAAAACTGGGTTGTTGGGTATATTTTGGAAGTGTGCCAGAATTGGTGA ACGGAAGAGTCCGTATGTTGCAGTGTGCTGTATCGTGATGGCCTTCAGCATCCTTTTCATA CAGTAGCTTGGAACAACGCCAGAATTCCAGGCGCTATCAGATTTAAATATGACAAAAAAG GACGATCTGCCGAAAATAGAGGAAAGAATGGTTAACCCTTTATCTCTCAAATTGAAGAGC TACACTCTCACTGCGTTCTCCTTTTTGTATTGGACCAAGTCTTATAAAAATTAGAGTAACAT

TAATACCGAGTGAAATGGNCTGAACATCACCCACACTNCGCTCATATACATTTGCTTGTCA TCTTTGGCTGATCAGCTTAGGAGATCTTAGCCAAGAAAAACAAAGTAATATAGTCCCTTCT GGATGAAG >'990729A-029.scf came from CONTIG 25 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-029.scf(55>468)

GCACGAGGCTGGGCTGTGCAAAGCTGGGTTTGCAGGAGATGACGCCCCCCGCGCCGTCTT TTCTTTCATTGTGGGGCGGCCTCGTGACCAAGGGGGTGATGGGGGGAATGGGGCAAAAAG ACAGGTATGGGGGAGATGAAAATCAAAAGAAGGGGGGGGATCTTACTCTCAAATACCCC ATTGAACACCGCATAATTACTAACTGGGGTGACAGGGAGAAAAACTGGCACCACTCCTTC

TACAATGAGCTGCGGGGGGCCCCGAGAACACCCCACCTGTCACAAAGCCCCCCTGAACCC CAGGCAACAAGAGAAAGACCAAAACAAGTTGAAACTCAACACCCGCAGGACGCGGCCTC AACTGGCTTCCTCTTTGCTTGGCGACAACGCAGGGCCGGATTAGGAGGGGACCACA >'990729A-032.scf came from CONTIG 26 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-032.scf(58>61) TTGC

>'990729A-033.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-033.scf(54>518)

GCACGAGGGTGGAGTCCCACTGCTGTGCCTCGGATGTGAAGCTCAAGCTGTACGACCGGA GTCTGGAGTCAAACCCGGAGCAGCTGCAGGCCATGAAGCACATCGTTATGGGCACCACCC GCCCCGCCCCCTACATCATCTTTGGGCCTCCGGGGACAGGCAAGACTGTCACCCTAGTGG AAGCCATCAAGCAGGTGGTGAAGCACTTGCCCAAAGCCCACATCCTGGCCTGCGCTCCGT CCAACTCAGGGGCTGACCTCCTCTGTCAGGCCTCCGGGTCACTTACCCACTCCATCTACGN

CCTCTGGCGCCCACAGGATATCCCCTGGCCCTGAGACTCAGCCCTGTGTTACTGGAGCAAA GAGGGATTTGTTTTTCTTCAGAAGAGCTCAGNATTCGNGCTTATTACACCTCTCCTGCAGC GTGGCTCAGCACTTCCTCATCCTCCACCTCTTTCGCAGCGGC >'990729A-034.scf came from CONTIG 28 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-034.scf(46>481)

TGGAATTCGGCACGAGGGCGAGAGGAGGGGGCTGGGCCGTGGGGAGCCCCGCGGAATGG GGCACCGTGGGCTACTTCTGCTGATGCTGTTAGGCGGGTTCCTCTGGGACGCATTCACCGG CTGACGCTGACGGGGGAGAAGCGAGCAGATATCCAACTGAACAGCTTTGGTTTCTACACC AACGGCTCCGTGGAGGTGAATCTGAGCGCTCCTGAGGCTAGGCCGCCAGGATACAGAAGA

GAAGGCCCCGCTGTGGGGGTCAGGCTGACCCGGTGAGATCTGCAGCATTCGCTCCTATCA ATCGGGACTCATGAGTGGCTCTACGGAAAACAGAGCAGCCCTGGTCTTACTCACAAACAA GGATTGGAGCCAGTCGAAAGATGGGAGCAAAAAATATTCTCTTGCTGGCTCCTCGCATCA CCTCAACAGGCTCCGA

>'990729A-035.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-035.scf(49>380)

GGGGTGGGAGCAGGAGGCACGCGGGGTGTGAGGCCACGCATGAGCGGACGCTAACCCCC ACCCCAGCCGCAAAGAGTCTACATGTTTAGGGTCTAGACATGTTCAGCTTTGTGGACCTCC GGCTCCTGCTCCTCTTAGCGGCCACCGCCCTCCTGGCCCTGCTGGCAAAGAAGGCAGCAA AGGCCCCCGCGGTGAGACTGGCCCCGCTGGGCGTCCCGNGGAAGTCGGCCCCCCTGGTCC CCCTGGCCCCGCGGGGAGAAAGGGAGCCCCTGGGCTGACGGACCTGCTGAGCTCCTGCAC TCCTGACCTCAGGTATTGCGGACACGAGGGGG

>'990729A-036.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-036.scf(55>461)

GCACGAGGGACTGACAATGATCTTATCAATATTCTTGGACCCTTTTTATCATCTTTCAACT AAAAGTTTCAAAACACAACTTTTATCACAATCCAGAACTGACACCAACAAAAATATTAAA ACAAAACACCCCTTGAGAAACAAAATGAACGAAAATTTATTTACCTCTTTTATTACCCCTG

TGATTGTAGGTCTGCCTCTCGTGACCCTCATCGGACTATTCGCAAGCCTACTATTTCCACAT CAAACCGACTAGAAGGCATCGCTTTGTACCCTCCACATGAATACTCTACTTGTATAAAACA ATATGAGTATCACAATCTTAGGACAAACAGACATTATATTATATCTTGTCCTTTTGGGAGC ACAAACTACTAGCCTTACCCCCTCTTCCACCACACACACAT

>'990729A-037.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-037.scf(55>532)

GCACGAGGGCCCTCGGCCCATTTCGAGTTCAGACAGCGACAGTGATAAATCCACAGAAGA CCCCCCAATGGGTGAGCCTCACCATCACCCAACCCCTCCAATAGAGTGAGCGAAGCTGCC ATCCTTCCCAGCATAACTCCCACCTAGCCCTTCATTTGCCCATAATATATGAGAGCTAGAA

GGGCCCTTAGGAAGCCTGTCATTCAATCCCCTCACTTTATAGATGGGGAAACTGAAGCCC AGAGCCACTAACCCAACCAGATTCCCATCCGGGGGCCCTTCATTTATCACTTCACCTTTTC TCTTCTCATTCTCCTTGGGGAATATCCTTTAAGCCACTGTGTCCTAAGGCTAGTAACTGCCA AGGGAAGTGCAAGGGGGGGGCAGGGCTGTGGGCGCTGGGGTGCACACGCGCCAGAGTGG CTTGCTGGTGAGGGTGAGGAATTTCAGCCAGACGGAAAGCCAGCTTGAGACCCCT

>'990729A-038.scf came from CONTIG 32 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-038.scf(49>243)

GTATGAAGTAAGGTTTTAGTTGGTTCAAATGATTCCAAATGGGGGGCGGTTGGCTTGGCAT ACAGAGGACACTCTGGGGTGTGGGAAGGTGGGGAAGGAAGGGAAGGAGAGGGCCGCCTG

CCGGGGTTGTGTGTTTGAAGCTGATCTCCCGAGCGGCCCCGTGGCGCCTGGCCTGCGTTTT GTGTGAGTTGAAAG

>'990729A-039.scf came from CONTIG 33 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-039.scf(l>603)

CCGGGCGGCGGGCGCTCTATAACTATTGGGTCCCCCGGGCTGTTTTTTTTCGGCACGAAGA TGATGTTGAATGGTGTTGTGTGAGACCTACAAGACCTTTTATTAACTAACACCCAAAAAAG TCGTGCTTTTATTATGGGGGACGGAATACAAAAGGAGGAAGGAAAGAAACACCTGGGGG AATGGGCGGATTGGGCCTTAGAGGAGGGGGTGAAGCAGGGGTTGGGGGTTTGTGAGTTTT GTCAAAGGAACGCACTGGTCGTAGCCAACACCCCCCCTTCCAACAACACAGGAGATGACT

CAAGGAGGGGAAGCCCTTTCCAGCCGGAAAAACAAGACCGGGTGCGAGATGTGGCGAAC ACATGTACTCCCTTTGGCAATTCACACTCAAATGAAGATGTGGGGAAACCACCACCCCTG CGGGGTGCCCTCCTTAATCCTTTTGCTCTCATTGGAGGTAATTGGCTTTAGGCTGGTCCGTT GTCGGGGCGGCGACCTTGTGGGGTCGTGCTTGCTTGTTCGGCCCGCCCCCCCCGCCAAAC

>'990729A-040.scf came from CONTIG 34 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-040.scf(39>122)

CGGGCTGCAGGAAACCGGCATACGAGGGTTGAAGTTGTATTGGTGTCTTTTGTAGACAAT ACTAGAAGTGTTTTTATTATTTAT

>'990729A-041.scf came from CONTIG 35 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-041.scf(48>56)

TTTTTTGGC

>'990729A-042.scf came from CONTIG 36 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-042.scf (46>511) TGGTTTTTTTCAGTTAAAAAGGCAAAAACTTTATTTAGTTTTTGGGGGAA^ ATGTAAACATAAAATACAAAACAAAACAACCCAAATCTTACAGTCTAGAAGCATGCCAAG ACAGAACATTTTCTGCAGACCAGAGTCCCGTCAAAAGGATAAAGGGCACCTGGAAAGGG GGGGGGCAAGGGGCTGGGTCCCTTCCCCAAGGACACTGCTTTTTGTGATGAGAACAACTG AAAAAAACCAACCCATTATAAAAATATAGAAACTGAGACAGTTTACACCACCTGGGCCTG GAATTTTTAGCCTCGACTGCCTGATTCATGTTCTTTCTTCGTTCTGTGTGAGGAGAAAGGG ATGACCCCGCAGCCCCAGGCCCTGGGCGGGGGGGGGGGGGCACGGGAGAGGCCCAAACA

ACAGTGCTCGGCAGCAGAACCCAACCACCTACAACGCCCCACCGCT

>'990729A-043.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-043.scf(55>565) GCACGAGGCTTGCCCGCCACCCGTGCGCCCAGTCCGAGAGGCCAGCCCAGTTCTCCCGGT

CCTCACTGCCCGCCGGCCGGCCCGTCCCCCACTGCAACCATGGACGCCATCAAGAAGAAG ATGCAGATGTTAAAACTGGACAAGGAGAATGCCATCGACCGCGCAGAGCAGGCTGAGGC CGACAAGAAGCAAGCTGAGGACCGCTGCAAGCAGCTGGAAGAGGAGCAGCAGGCCCTCC AAAAAAGCTAAAAGGACGGAGACGAGNGGAAAAGATTCTGATCAGGAAGGATGCCAGA GAAACTGAGCAGCTGAGAAGAAGCACTGTGCTGAGCAGAGGGCCTCCTGACCGGCATCA

CTGGAGAGAGAGCTGACGGCCAGAGCTCTGCTCAGCCGAGAGCGGGGAGTGAAAGAGTG AGAAGGAGAAGATGAGTCATGAACGACTTGAGAGAGAAAAGAGTGAGAAGCATGAGAG CACCATGCGGATCGACGAATGGAGGGCGAACGGATCGAG >'990729A-044.scf came from CONTIG 38 at offset '

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-044.scf(49>550)

CCAAGGACGCCTTATGACTCCGTTTACTAAATGTACCACTCAGACCTGCAGGCCTTGCTTG GGGTGGGACCTTGATACTGGAGTTTTGGTTATTAATCCTTCCTCCTCTGACCCTAAATTCA GAACACAGAAAGGGATCCAGTCAGGGAATGGAAGGAAATCTCACCACGAAAGGCTTAAG TAAACTCTTAAAAAGCAGTTGTATTGAGGTATTTTTTTAAGTGCACAATTTGATAAGTTTT

GACATCTATATGAAATCATGGCCACAATCAAGACATAGGTGTATCTCTCACTGCCGNACG TTACTGCTGAAGACGTCGTTTGCTATTACTCTCTCAGAATCTGAGCACTGNAGATCAGAGA CTGATTACAGGGCCCTATGACCTGTCCTATCTTCTAAGACCGCGAGAGCCACAGACTACA GCTCTGAAGAGATAACGGCCAAAGACTTGTACGAAACAACAGCTTCTCAGACTTTATATG GTGATAGACGAGACGAGAA

>'990729A-045.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-045.scf (55>561) GCACGAGGCTTATCTCCAGGTGCGTACGGGAGCTGAGGTGGGCGAAACTTCGAGGGGTGA GGAGAGGGTGCCGGGATCCAGGTGTGAGAGAGGGGTGGGCGTGAAGGCGAAAAGAACG

GGCCCGCCCCTTTCCGGCCTGGAAAGTAGTTTCTGTGGGTCCCTGGGAACGTCGGAATACC AGATCTCGATCCGTGGGGGCGGGGTCCCTGGGGGAACTTGAGCGCCCCCTTCTGGGAACC GGCGGGTCTGTTCGCAGGGACTGCTGTTGGGGCCTGATTGGTTAGACAGACGTTCCCCGA AGCCACGGGAAGCCCTACCCGCGGGGCGTGGGTGGGGGATCCCTACTTAGTACTCCTGCC TCTCCTGCATCGCAGCCCCTCCCTAGTGCATTGTCCCTGTCCGGGCCATNAGACATGCACC

ACCACGCGGCGCTCTGTTGAGAAGGAAGGACCTCGTCTCAGCTTGCTGGGAGAACCGAGC CCTTGCTCGCCACAACGGAAAAGAGAG

>'990729A-046.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-046.scf(55>533)

GCACGAGGCTGACATCGGCCTCCTGCAGAGCCTCCAGAACTTGGCCGTCACGGCCAACCG GATCGAGGCGCTGCCACCCGAGCTCTTCCAGGGCCGGAAGCTGGGGGCCCTGCACCTGGG CAACAACGTGCTGCAGCCGCTGCCCTCGCGGGTGGGCGAGCTGACCAGCCTGACCCAGAT CGAGCTGCGTGGCAACCGACTGGAGTGCCTGCCTGTGGAGCTGGGCGAGTGCCCGCTGCT CAGCGCAGTGGCCTGGTGGTGGAGGAGGACCTGTTAACACCCTGCCCCTGAGTGAAGAGC

GCTCTGGAGGTGACAGGAGCAGCCTGAGTCCATGCATGAGCACGGTGCCCTGGGGGCGCC GCACCGACCCCAGCAGCCTGACCCGAACCAGAGCGACGACACCAGCACCTGCAGAGGCG CGGGCTGNCGACAAGACGACTGAGGTGCCCTTTTCTGGATAGCCCCAGCGGCGCGAGGAA >'990729A-047.scf came from CONTIG 41 at offset

0;"E:\SEQUENCE\export\EST db\990729a\990729A-047.scf(55>544)

GCACGAGGCTCGCTCCGGTGTCCCCGCGCCAGAGACACAGCAGCGCTCCCTCTGCCCACA CCCACCGCGCCCTCGCGCTCGCCTCTCCTTCCGGAGCCAGTCCGTGCTACCGCAGTCGCCC AGCCCACCACCACCCTCTGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCA GGATGTTCGGCGGCCCCGGCACCGCAGGCGGCCGAGCTCCACCCGGGCTACGTGACCACA TCCACCCGCACCTACAGGCGGGCAGGCGCTGGCCCACCCCGCCGCACCTTACACCTGTCC CGGTGGCGGGTCGCCAGCGCTCTGCCGGCGCTGGGGGGGGTGCGGCGGCGGTGTGAGACC GGGGACTGCTGTGGCAGCCTCACACGATCAGACACCGACCACAGAGGAGCGAGACCAGA CCGTCCACACCGCAGGCGCTCGACAAAACAACGTGCGACGAGGCTAGGCAGCAGGGCGG

GACTTCAGAG

>'990729A-048.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-048.scf(46>593) TGGAATTCGGCACGAGGCACCAACCGATTCGACCAGTTATTTGACGACGAATCGGACCCC

TTCGAGGTGTTGAAGGCAGCAGAGAACAAGAAAAAAGAAGCCGGCGGGGGCGGCGTTGG GGGCCCTGGGGCTAAGAGCGCAGCTCAGGCCGCAGCTCAGACCAACTCCAATGCGGCGG GCAAACAGCTGGGTAAAGAGTCCCAGAAAGACCGCAAGAATCCGCTGCCCCCCAGCGTC GGCGTGGTTGACAAGAAGGAGGAGACGCAGCCGCCTGGGCGCTGAAGAAAGAGGAATAA GACGTGTTGGAAGAGACCTGATCAACAACTTCGGGTGAAGGGAAGATAATGAAGGAGAC

CGAAGGCGACCACCTGTGAAAGAGATTCGAAAGCCATTGAGAAAGGTNGAGGAGAGATT TCCGTGATGACGATTTTGCCGCCTTCCGAGCCGGTGGTCTGGAGGGCGGGAGCCGGACGG GAGGGCGGAGAGCTTGTCTCGGCAACGGATTGTAGCTGGGAGGGGACGCCGAGCGGGCA AGGGGGGGATGAACC

>'990729A-049.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-049.scf(49>505)

TCTTGCTGCCGGATCTGGCTTCCGTGGGGACCCTCCCTTGATGAATATGGCCGTCCTTTGCT TATTATCAAGGATCAAGACCGCAAGTCTCGATTTATGGGACTTGAGGGCCTCAAGTCTCAT ATAATGGCAGCAAAGGCTGTGGGAAATACAATGAAAACATCG'CTTGGACCAAATGGGCTT

GATAAGATGATGGTGGATAAAGATGGAGACGCGACCGTGACCAATGACGGCGCCACCAT CTTAAGCCTGAGGACGGTGACCCCAGACGGCAGCTGAGGCTGAACTGCCAAATCCAGATG TGAGAGGGAGAGGACCACAGAGGGTTGGCTGCTGCGCCTGGGGAGAGCGAGAGAGCTGG CCGGGATGACCCACGAGGCCGCGATACAACGCGGCGCTGCTTGAAACCGACAATANGAC GGGCTGAGACGAAAACGTGCCCCTCAAGCAGACCGCT

>'990729A-050.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-050.scf(46>198)

TTGGGTTTACATCTCCCCACATTTCATACCAGTATTCCAACAGATTCTTTATTACTTAAACC CAAAACCACTTCAAACCATTACCCTTGGATTGGGACTTAGCCTTTAGCTGTGCACACGGAG

AAAATTCGCGCCACATTTGGGCCTCCACAC

>'990729A-051.scf came from CONTIG 45 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-051.scf (45>193) TTTGAATTCGGCACGAGGCTCGGGTTTTTTTTTTTTTT^

CAATAAGCAACTAGGGTTAGCCCACATAAATATGCTACCAATAAATGAGAACGCTTAATG GCTTATTACATGCTATGTATGTGCTT

>'990729A-052.scf came from CONTIG 46 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-052.scf (45>513)

TTGGTTTTTCCTTACTTGGAGATCTTCTATATAAATACTGTAAATGACATCTTTTCGTACGG ACCTGTTCGAGCGTTGCTTTCCAGAGCCCACGAACAGTGCTGGCCCGATCTTGGGCTCTGG CTGCCCCATCCGCGTGGAGCCCTTGCAGGAAGCCCCGGCGAGCAGAGGAGCCGCGCCTGG GTCCCAGCAGCGCTCACTAGTCTGTCACTTGGCCCGGNGCGGGCTCGTCGTCATCTTCTTA TGGCCAGGATGTACTGACTAAATCTGGTTAGCAAATCAGACCTCCTCCCTTCAGAGCATAC

AGGTCATCTCCTCAGCTTCCTCCACCGAGCTCGTGGGAGGGGCGGACCCCGGGGCTTGAG GGGAGGGGGAGCTGCCTCCTGGGAGCTGAGCCCTCCAGACAAACCTTCTTCTCCTCGCAT GCAACAGGCAGACCCGCTTATCGTCATCACTTCAAAAGAAGAGC >'990729A-053.scf came from CONTIG 47 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-053.scf(56>573) GCACGAGGAGAGAACTAGTCTCGAGTTTTTTTTTπ

AACCCAGCATCATTTGTTCTAATGCTTCTTGTTGGCAGCTGCCACCTGTCCAGCGATTCTGT CCAGATCTCTCTGTCCCTGAGGCGTCAGTTTGCGGCCCCCATCTTGGTCCTTTTCCACCATT TTCAGCCCCTCCAGGGCTTGGAGGACCCGCCGGGCCAGGCTCTTGGAGCCTCTGCTGAAGT GGGTGGGCATGACGCCGTTCCTCTGGCGCCCCCCATAGATCTTGGTCATGGAGCCAACCCC ACGCCACCCCGGGGTACAGGGGCCGNNGGCCGGGAGCGCTCGGGTGTAGACCAGTCTCA NGTAGGGAGCAGTTTTTATGCTGGCCGCTGACGCGTCCACCATCAGGACTTCAGCTCCCGA CTTTTGGGAAGCTGCAAGCTTGACACTCTGCTGTGAATCTTAGGCTCTGCCTCAGGCCGGG

GTCCGTGTAACACGAACGGGGACGTCCGC

>'990729A-054.scf came from CONTIG 48 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-054.scf(56>577) GCACGAGGGATTCAAAAAGTAATAAGCAACCTTTTGAACCTATGATTATTTATGCACACTT

CTAGTTTTGTTTTGATATTTAAGAACTGTTGATCATCTAAAGTTTCTATGCACAAAGCACTG GCATCTTCAAGCAATTTAAAATTTGAGAATATCCATCAAAAATTCTTACCTTCTGGAGATG ACTTTGTCACATATAGAGTTATTGAATAAGCATGTTGTGCACCTGGAACCAACATAGGGCT GTAGGTCAATTATACTTTCAAAAAAAAAAAGTTCTTGCCTTCCTTATTCTCAAGCATCCCA AATTTTGCAACCTCCNTCTTTCTGGCCCCAATCACCAAAGAAGATGGACCCTGCCCAGCCC

TTGCTTTGAGCCCCTCCCTCCTTCTTCCTCAGCTTCCTGAGACGCTATATGAATGACCACAC NCACAGAAAAACACTGGTTTTCCTTAAGGTAGTTCCGGGGGGGGGGAGGCCCAGACCAGA GGCCGGACAANACAGAAATGGAGAAGACGNTTC >'990729A-055.scf came from CONTIG 49 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-055.scf(56>534)

GCACGAGGCAAGTCTCTACATTTGTTTCTCAGGCAGGTTCTAGTATTTTTAGGGGCAGGGT CAATCGAAATTGACCCTTCAGATTAGTCAATCCAAGTTACTGACATTTCCAGTATTACTTA GTATTTTTTTGTGTTATGTTGGCGAGTAGGCTTTTCATATTTTTATACAATGAAAAAA^ AGCCCTTGGGTGTATCTCTAACAGAATGTGCTCATCGACATTTACTAGCACAAACTTTCAG

TTTTGATTTCATCAAACTCTACTTTAACTGACCCATATTATTCTCTTATCGCAAGACTTAGT GAGAAAGAGAAAGCAGTTCTGACCATCGGAAAGGCCTGCCAGCTGCTTTGATTATAGGGG CTGCCGGTCCAGGACGNTGGCACAAACCCACACACACAGAGACAGGCCTCGGATGGAGA AGGANAAAGACAACAAAACAATACATTGTTAGGCTACAGGAAGGAAACTACGC

>'990729A-056.scf came from CONTIG 50 at offset 0;'Ε:\SEQUENCE\export\EST_db\990729a\990729A-056.scf(56>450)

GCACGAGGCTTCACCGTCTCTGCCATGCACGGGAAACATGGGACCAAAAAGAACGAGAC GTTATCATGAGGGAGTTCCGCTCTGGCTCTAGCAGAGTATTGATTACCACTGACCTACTGG CCAGAGGTATTGATGTACAGCAAGTTTCCTTAGTCATCAACTATGACCTCCCCACCAATAG

GGAAAACTATATCCACAGAATTGGGCGTGGCGGGACGTTTCGGCCGTAGGGTGTGGCTAT TAACATGGTGACAGAGAGGACAGAGGACTCTCGAGACTCGAAACCTCTACACACCTCCTT GGGGAATGCCCTCATGTTGCTGCCTCTCTGGGGGGGCTGTTGGCTCCTACCACAGCCGGCT GAAACCTGGGGGGCGAGGCGCAGGGANGGGGGA

>'990729A-057.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-057.scf(56>460)

GCACGAGGATTGATCAGAGCATTGAGCAATACAATTTAATTCACTCCCCCTCCCTTTCCCC CTCTCCAAAAGATTTGGAATTTTTTTTTTTCAACACTCTTACACCTGTTGT^ ACCTTTGTAAGAAAACCAAAATAAAAATTGAAAAATAAAAACCATGAACATTTGCAAAA

AAAAAAAAAAAAAACTGGAGGGGGGGCCCGGTACCCAATTCGCCCTATAGTGAGTCGTA TTACAATTCACTGGCCGACGCTTACAACGTCGAGACTGGGAAAACCCTGGCGTTACCCAA CTTAATCGCCTTGCAGCCATCCCCCTTTCGCCAGCTGGGCGAATAGCGAAGAGGCCCGCCC GACCGCCCTCCCACAGCTGGCAGCCGATGGGAAGGCAATGGGG

>'990729A-058.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-058.scf(56>590)

GCACGAGGATCAGCCGCTCGGTGACCGTCACAGGGCCTACCTGATGCAGAAGATGAACCT GTCGCTCAACGATGCCTACGACTTTGTCAAGAGGAAAAAGTCCAACATCTCACCCAACTT CAACTTTATGGGGCAGCTGCTGGACTTCGAGCGGACGCTGGGGCTGAGCAGCCCGTGTGA

CAACCACACCCCCAGCGAGCAGCTCTATTTCTCCACACCTACCAACCACAACCTGTTCCCA CTCAACACGCTCGAGTCCACGTGAGGCCGGGGGCACTGGGCGATGGGCTAGCCCCTCCCG GGCCCCCACAGGGCCCGCCGGCAGGGCCCCAGCCTGCCGCCTCTGGCCCGAGGACCCAGA CTCACCGTGCCGGGTGAGCTCCCTCAGGTCCCACACCGGCCTGCACGGCAGACTTTCGAG GGCCGAGCGACAGACACAGGCTTGGAGTCCTGGGCCTCTCTGNCCAGACCTCTTCTGTGA GCTCAGCGNTGCTGTTTTTAAGACACCACGACGGTTACTTTACTTGCAGAACCC

>'990729A-059.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-059.scf(46>550)

TTGGTGCAGCGCCTCTCGTCTTGCAGGCTCTCCTAGCTTTCGCCTTTTCGCTTCCGGAAACA TGGGCCTCCGGTGTGGCTGTCTCTGATGGGGATCATCAAAGTGTTCAACGACATGAAAGT GCGTAAGTCGAGGACACCAGAGGAAGTGAAGAAGCGCAGGAAGGCGGTGCTCTTCTGCC TGAGTGAGGACTTGAAGATTTTTATCCTGGAGGGGGGCATGGTGATCCTGGGGGGTGTCG TGGGCCAGACGGTGACGACCCCTTTGCCCCCTTGTCAAGATGCTCCAGACAGGGCTGCCG

CTCGCCCTTATGTGCACCTAGAACCCAGAAGCGGAGGGGGCCTGTGTCTTCTCTGGCCCCG CGGGCCCCCCTAGACAATGACTTGCGCTCCAGACGCTTATAGAGCTGCGGGTCAACTGAT TACAGCCACGCTCAGGGGGCAACCCTCCCCTCCGAAACCGGGCACCTCCTTTCCGCGGAG CCTGGGCCCCCACCCTCTGGCTG

>'990729A-060.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-060.scf(30>644)

CGGATCCCCCGGCCTGCAGGAATTCGGCACGAGGGTTTTCATGACCTGCTATCGCAGCTG GATGATCAATACAGTCGCTTTTCTTTGGAGAATAATTTTTTATTGCAACATAACATAAGGA AAAGCAAGCGTAACCTTCAGGATAATTTTCAGGAAGACCCAATACAGATGTCTATGATCA

TCTGTAACTGTCTGAAGGAGGAAAGAAAGATCTTGGATCATGCCCAGAGAATCAGCCAGG CGCAGTCTGGGAATATCCAGAGCACTGTAATGTTAGACAAACAGAAGGAGCTTGACAGCA AAGGCAGAAATGTGAAAGACAAAGTTATGAGTATTGAACATGAAATCAAGACTCTAGAA GACTTGCAAGATGAATATGACTTTAAATGCAAAACCTTGCAGAACAGAGAACATGAAACC AATGGCGTGGCAAAGAAGCACCAGAAACAAGAACAGCCGTTACTCCACAAGATGTCCTA

ATGCTGGACAATGGAGAAAGGAGTTGTCCCAAAAAATAGAGTGGTGAATGCCACTGACTA CCCAGAGCCCGATTATGATGACTGGGGGGGGAACGGGACAGCGAGGCGGTTGGGGGCCC CACGCTGCCGTTAATGT >'990729A-061.scf came from CONTIG 55 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-061.scf(47>604) TGGTTTTTTTTTTTTTTTTTAATTGTTCAAGCT^

AATTGATAAAACACTAGGAACTAATTCACAACTCTTTCTACCCTCTTTTTATGTCAAAAAT ACAAATGACTATCCATTGCATATCAGGAGAAATTAAGCTTTTTACAGAACAGGTTGGAAG AGAAAACTATAGGTGATAATTAATAAGAATTTAAGAATATATTTTCCATAAAAACAACAA

ATGAGAACCTCTTACATAAAATTCTAAATACATGCTAAATATATTAGGAAAACAAACATA TTTTGGACATTGTTATACATGCCTATAAAANGAGTTGGGGCTGTTAAAAAACTAATAAAAT GCTACTACCANACTATATACAAAACTCTTAAAACTAGTTTTCTCTTACATATGGCTCTGAA TATTTATGACACAAACTATTCACGAACAGACGGGATCATTGAGATGAGCAAATTAAATTA TTCCCGGAAAAAACCTCAGTTTCATTTTCCTATTAATAAGTGNTAATACTGGCCATCGTGA

CGCATAAAAAG

>'990729A-062.scf came from CONTIG 56 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-062.scf(50>470) GGAGAGTCGGTGGGATCTCTTTACGGCCTCTGGACTGGAGGCCGAGCCCCCGCCCGCGGC

CGAGCCCCGCGCCCGGCGTCTCCGGCGGGGTGCTCTCCGCAGTTTCCTGGCTTGGAAGCCA TGGGAACATGGCGAGGCAGCGGTGGTTTAACGGGAAGGACGGAGACTGTTAGCCTGTGA ACGAAAGCGAGAGTGAGCCGCCTCACGCTCCGGACCAAGAGTGATCTTGAACTTGTGGCT GCTACTAGATTTTTGCCCACACCTCCTCGTATGCTGCGGCTTCTCCATGGAGTGGGGCCAG GGTGACCGGGGACTTGCCGCAAGTCAGACGGCTGCAGGTCACAGCAGTCCAGNCTGTCCA

CCTTTGAGCGCGGGCGCATGTCCTTCCCACCCCGAGACCCCGCTGGCTTGACCCAAAACG

>'990729A-063.scf came from CONTIG 57 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-063.scf(47>374) TCTGGTTCGTGTTTTTTTTTTTTTTTT^

ATAAAACATTTGGGAGAGATTTGTAAAAACCAGGCCAGCCCAGGGCACTGAGATACTGGG ACAGGGTATTTCCCATGAGCATTCCTTGGTGGGGGTCAGGCCGTAGCTCTGGCTCCATTCG GTTTGGTGGGCTGTTGCCTCGCCCCCCTTTGCTGCCCTGTAGAACACACGGGGGGGACTGG GGGCGGGCAATGGATCCCCTTGCCGGTCCTTGCGCCCGGCTTCTGGGGTCCTCAGCTGACC TCCCTCGTTTCGTTTCGGGGG

>'990729A-064.scf came from CONTIG 58 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-064.scf (51>548)

GGACTGTGGAGAAGGGCAAGGACCCCAAGGGCCCCGGAGGGTGAGGAGTCGGAGGAGG AGTGGGCTCCAGTAGAGAAAATCAAGTGCCCCCCCATCGGGATGGAGTCACACCGCATTG AGGACAACCAGATCCGGGCCTCCTCCATGCTGCGCCACGGCCTGGGTGCACAGCGAGGCC GGGTCAACATGCAGGCTGGCGACACTGAGGACGACTACTACGATGGGGCGTGGTGTGCTG AGGATGACTCCCAACCCAGGGATAGAGGGGACACGAGAAGACCACAATTCACAGCGCCA

CACCAGGCCGGACTCCGCATCATGACACTTGGACCCCTCTCGGGGCTCACACGACGCAGC GGGGGATGACACACGCTACAGAAAGCTTCAGGGACGGATAGACCGCCGGCGACGACTCC GGCGNAGGCCGTCATCCACACCTCCCGAAGAGCGGCGCGCGAGGCGGGGCCGGCCTGCC GTCACGCGAGGGGACCGGCCGCT

>'990729A-065.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-065.scf(48>589)

TAGGCAACTCTATCAAACGCTTACTAATTGGAAGCCTCTTCGCAGGATACATCATTTCCAA CAATATTCCTCCAACAACAATTCCCCAAATAACTATGCCCTACTACCTAAAAACAACAGG CCTAATTGTTACAATCCTAGGCTTCATCTTAGCCCTAGAAATCAGTAATATAACTAAAAAT

CTAAAATATCACTACCCCTCAAACGCCTTCAAGTTCTCAACCTTGCTAGGGTATTTCCCCA CAATTATACATCGCCTAGCTCCATACATAAATTTATCAATAGCCAAAAATCAGCATCCTGC CTCTAGACCTATCTGACTGGAGCCATCCTACCAAAACCATCTCACTCGCCCAATAAAAGCT GTACCTGGNCACAAGCAAAAGACTGATCAACTTATTCCTTCCTTCTATCACATCCTATAGA TATCTATTATTACAGAGTATTCATATACCACACACATAAAAGACACCATACATACTACAGA

GCTACTGTAAGCGAGTCTTGCCTTACTAAGACAGATCCGTTATAATACATCCTAN

>'990729A-066.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export EST_db\990729a\990729A-066.scf(44>143) TTTTTTTGCCAGCCACTTCTACCGGCAGATTGGGAGGCGAGCGCTGGGTGTGGAACATCAT

TCTCACCACCAGTCTCTTCTCTGTGCCTTTCTTCCTGAC

>'990729A-067.scf came from CONTIG 61 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-067.scf(49>55) ATGAATT

>'990729A-068.scf came from CONTIG 62 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-068.scf(57>391)

GGGCACGAGGCGGTTGTTAACCTGGGGTATGTTGGTTTCGTGGAGATGCCCATGAGTGTTT TATTTCACCTGGTGGCCAGAGCTGAAATGGAACTTATTGAAAAGTAAGGTGTAAGCTTAG

ATGGAAAGAAGATCTTGGTAATAGGAGCCCATGGGTCTTTGGAAAGCCACCCTACATTGT GTGTTCCAGAGAAAAGGGACCATGACAATGAGCTACCAGTGGAAAACACCTCAGCTGCA AGACAAGCTACAGGAGGCTGGTCTTGAGGTCTTGGGCTCACCCAAGCCAGAAGAGATCCC CTTTCTTGGTTCAACGGGAACTACTGTTTAAACTG

>'990729A-069.scf came from CONTIG 62 at offset 2;"E:\SEQUENCE\export\EST_db\990729a\990729A-069.scf(59>496)

GCACGAGGCGGATGTCAACCTGGGGAAGTTGGTCCGAGGAGATGCCCATGAGTGTTTTAT TTCACCTGTGGCCAGAGCTGTAATCGAACTTCTTGAAAAGTCAGGTGTCAGCTTAGATGGA AAGAAGATCTTGGTAATAGGAGCCCATGGGTCTTTGGAAGCCACCCTACAATGTCTGTTCC

AGAGAAAAGGGTCCATGACAATGAGCTCCCAGTGGAAAACACCTCAGCTTCAAGGCAAG CTACAGGAGGCTGATATTGTGGTCTTGGGCTCACCCAAGCCAGAAGAGATCCNCCTTTCTT GGATTCAACCGGGAACTACTGTTTTCAACTGTTCGCATGACTTTCTATCAGGGAAGGCTGC ATGCATTTCTTCTGGCGTCCATGGTATTAGCCCCATCGCCAAGATGTGGNTCTCCTTGCTG CTGCTCTGCGAATA

>'990729A-070.scf came from CONTIG 63 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-070.scf(55>274) GGGCACGAGGCGTGTTTTTTTTTTTTTTT^

TCATTACCTAATGGTCCACTAAATTTACATATTCAGGAAATTATATATAGAATACTGCAAA AACACAGTAGAAGACTGAAGGTGGCCCGGTTCAGCTCATGAAATCCCTTCACTCCCAAGC ATGTTGTCCTTTGAACTCCAAAGTGAACTGGCTGGAC

>'990729A-071.scf came from CONTIG 64 at offset 0;"E:\SEQUENCE\export\EST_db\990729a\990729A-071.scf(54>478)

CAAAGAGCTGCCCCCATCCGAGTTCCTGCAAGTGGGCCGAGGGCCACGTGGTCTGGGGGC TGAACGTGGTCGCTCCCCCAGCGGGGGCGGGCCGGTGCAGGGCCGACCGGGGTTCACCAA GGATCGGCCCGGGTCAGTGGATCGGCACCCGCTGGGCCGAGGCACCACGTGGTCCGGGGC

TTGATGCTGGTCCAACCTACCTAGACATGACTTTCATCCTTGTGCGGGGAGCAGGGACCTG TCCGCGGGGGATCCACACGCTGGGCCCGGGAGTTCGACATTTACCGAGAGGTGGGCGGGG AGCCTGTGCCCTGTGCCAGGGACGATTCCAGCAACGGCTTCCCCGTGCCCAGCATGGGCC CAGCCCCCACGNGCACCCCACCAGAACCCAAAACCGATCTGCGTNCTCACGCTGACCCGA GACC

>'990729A-072.scf came from CONTIG 65 at offset

0;"E:\SEQUENCE\export\EST_db\990729a\990729A-072.scf(54>526)

TCTCGCGAGATCCGCCTCCTCAATACCAAGCGCCTGTGTGTGGCAGAGCCGGGGTGAGAC GAAGAGACAATCCTTCCCAGCCGCCAGGATAATCAAGAGTTTTGGCCGGACCTTCGAGCA

CACACCGAGATAGTGAGGAGCCAGACGAAAAGCACAGACTATGGCGGCTGAAACGGATT AATAAGGAACTTAGTGATTGGGCCCGCGACCCTCCAGCACAATGTTCTGCAGGTCCAGGG GGGATGATATGTTTCATTGGCAAGCCACAATTTGGGACCTAAGACAGCCCATATAGGCGG TGTATTCTTTTGACATTCATTTCCTACGACACCCCTCAACCCTAGNTGCATGACAACAGAA TTANATCCAATATAACGNAAGGCGCATTGTCTGAATTCAGACCAGTGTTCCTGTTACATTT

AAGTCTTTTCATTGTTATGTTGGACCAACCAAGACCCTAGGCGGATGCGACT

>'990809A-089.scf came from CONTIG 1 at offset 0;"C:\export\EG_DB\990809a\990809A- 089.scf(60>576) GCACGAGGCAGAGAGTCATAAAAGGTTTTTAGCAGAGGAGTAGTCTTTTTAGAACAATGA

TTCCGACAGTAGTATATGGAAATGGGAGCAGATACAGATTTAGGCAAGGAGGCCAGAAG ACGATCTCAACAGTAGTAACACTGATAAGAGGTATTGGTGGTCTAGATTAGAGTAAAATG CAAAACTAAGGTTAGATCTATTAAAATACATGACTCAAAGGAAAAATTGAAGACCTAAAA TTGGCTTCAATCTATTTAAAGAAAAAAAAAAAAAAAAACTCGGGGGGGGCCCCGGACCC AATTGGCTCTAGTGAGTCGTATACAATCACTGGCCGCCGTTTACACGGGGNGACTGGAAA

ACCTGCGTACCCACTTATTGCCTGCAGCACATCCCTTCGCCGCGNCGTATAGGAAGAGCCC GCCGTCGCCCTTCACAGTGGCAGCGATGGGATGGAGATGTAGGTATTTTGTAAATGCGTT ATTTGTTATAGTCTTTTTACAATGCGACGCAATCTTTA >'990809A-065.scf came from CONTIG 2 at offset 0;"C:\export\EG_DB\990809a\990809A-

065.scf(56>544)

TTGGTTTTTTTTTTTTTTTTCCAAAATGA^ ACTTGTAGCTTTGACTGCTCCTTCCGGGCATCTCAGGGACTTCGCTGCTCTTTTTTCCTAGG AACGCCCCAGGTTTCCGGTGGGAAGACTCTCGGGGCCCGGGATTCCTCGGGGCCGCCCGG

CCAGCCGGCGCCCGCCAGTGCCTCCGCCGCCCACGCGAGTCTGCTCGACAGAGGCGGAGC GTGGCCGAGCTCAGGCTGCAGCTGCGGCAGATGCGACAGCTCCAGTACGGCGGCGTCCCC GGGNCGGNGNCCCTGACCGGGCTCTCCCCACCGCTGCCTCCGCACCCCGCCCACACATGT GCGGTGGCTGCTTGCGCATCTTGTACGATGATGAGGCGGGGCAGGCGGCCACCGGCTCTC CTA

>'990809A-017.scf came from CONTIG 3 at offset 0;"C:\export\EG_DB\990809a\990809A- 017.scf(451>525)

AAATATATATATTTTTTTTTTTTTTTT^^ TCTTTTTTT

>'990809A-043.scf came from CONTIG 3 at offset 32;"C:\export\EG_DB\990809a\990809A- 043.scf(50>572) TGGTTTTTTTTTTTTTT

AATGTGATGTTTTAAAAATGAAAAAAAGAAGAAAGATGAACACAATATAAATTTGAATTG

TAAAATAGGACAAAATCAAGAAGTGGGGAAGCAGAAGGGGGAAAGGAGGGATGGTTGC

CAAAAGATTGAAGGGGCGCTGGGGCCTGTGGGGGGAATGACGTGTGGGGGGCAGCACAT

ACCTTTCCATATAAGGACAAAAGGGGTTGATCCGTCTCATTTTTTTTTGTTAAGAAAAGAG

GGGGGGGGGGGGGCTTTCTGGGGACTTAAGAACCAAGTTCTTTCTTGGTTTCTTGACCCCC

TTTTCAAACAGAGAAGGCGGGATTCACGCTTGTAGAAGAGATAAGAGGAAGAGAAGAAT

CCGACTGAGGGGGGGGCAGAACTGGAGGTAAGGCTAGGAAGAAGGGAGAGATGAAAGA

AATAAAGTCACACCGCCAGCGGGGGACGGGAACCGCACCAGA

>'990809A-061.scf came from CONTIG 4 at offset 0;"C:\export\EG_DB\990809a\990809A- 061.scf(319>477)

CACCACCTCAACATCTTTTTTCTTT^ ATTTATTTCCTTTAGGATGTGTGGGTGTTTTTTTTTTTTT^^ TTCTTCATCTTTTTCCTTTTTCTTCCCATCCT

>'990809A-095.scf came from CONTIG 5 at offset 0;"C:\export\EGJDB\990809a\990809A-

095.scf(62>535)

GCACGAGGCTGCCCTCTGGTCTGCCTCAGATCCAAGATGTCCAGTCCCCTGGAGCAGGCG CTGGCTGTGATGGTCGCCACCTTCCACAAGTACTCTGGCCAAGAGGGCGACAAGTTCAAG

CTGAGTAAGGGGGAGATGAAGGAACTTCTGCACAAGGAGCTGCCCAGCTTTGTGGGGGA GAAGGTGGATGAGGAGGGCCTGAAGAAGCTGATGGGTGATCTGGATGAGAACAGAGACC AGCAGGGGGACTTCCAGGAGTACGCCGTCTTCCTGCCCTCACACGATCATGTGCAATGATT TTTTTCAGGGCTCCCCAGCACGGGCCTGATGCAAGCTTGGGCTCCCTGCTTGGGTCTTTCG CCCAGAAGACTCTTTATTTTTTTTTTTACTCATAACTTTTTGGTGTTGCAGGAAAAA^

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTGGGGGCCGGCCCCATCG

>'990809A-056.scf came from CONTIG 6 at offset 0;"C:\export\EG_DB\990809a\990809A- 056.scf(53>609) TGGGTTTTTTTTTTTTTTTC

TCTAAAAGATATTTCTCCATGCCTGATGATTTGATATAAAAATCAAACCCATCATACTTTC CCCATCAGTCTCTCTACATCAAGGGCAATCAGAAATTTGTACAACATGAATATCTGCTTCT GAAACAAAAATTACAAATTAAGTGATAACAAAAATACACAAATCAACTGGACCCTAAAC AAATTTCTAATGAATTCTTCCCCCCACCCCCTCAATCACCTAGAGCTTCTTTCTTCAGCCTC ATTCTGCTCCTTTTCCTTTCTTTGCTTGGCCATGAACTTCTCTGTATTTTGCTTATGAC

ACTCTTGCGGGATTTGTCTTGCTTTTCTCTGAGTAGAAGAGGGACAATGGACAGAGGATCC AGCCTCGNACAGAAGTCTAATCTTAGGACACAGGGCCACGACTCCTGAGGCCTCATCTTT GCGTCTGGTGGTCTGATCTTATCAATCTCACTATGGAGGCTTCTCTTCTGTTCACGACACTT TCGAG

>'990809A-027.scf came from CONTIG 7 at offset 0;"C:\export\EGJDB\990809a\990809A- 027.scf(53>464)

TTTTGTTTCCCAAATGTCTCTCCAGACTGTCTACATCTCCGCTACAATCACCTGAGTACCAA CTGTGTCATCTCTCACCATTTGTATCTGTCTCCGTGCAATCCATCCTCCACTAGAGCCAGAA TGTTCTTTCCAAGATACAGATGTCAGCTGGCCATCCTCCATCATAAACCCTTCAATGGCAC

TCACTGCTCATTAAGTAAAGACATTCTGCCTTGTGGCCCCTGCTACCCTCTGTGACCTTCTC TGCCACCATGGCTCTCCCAGCTCACTCCCAGAGTCTCAGAGTTCATGTTTTCCATGTGACC TCCTGCACAGAACCTCTGCCAGTGCTCTTTATCCCCTCTTCACCTGCAATCCAAGCGCTACT TCTTCAGAAAAAAAAAAAAAACAACCCCTTACGGCGNTGCGC

>'990809A-079.scf came from CONTIG 8 at offset 0;"C:\export\EG_DB\990809a\990809A- 079.scf(58>614)

GCACGAGGCGCTGACTATTCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATT TGGTGCTTGGGCCGGTATAGTAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGC CAACCCGGAACTCTGCTCGGAGACGACCAAATCTACAACGTAGTTGCAACCGCACACGCA

TTTGTAATAATCTTCTTCATAGTAATACCAATCATAATTGGAGGATTCGGTAACTGACTTG TTCCCCTAATAATTGGTGCTCCCGATATAGCATTTCCCCGAATAAATAATATAAGCTTCTG ACTCCTCCCTCCCTCATTCCTACTACTCCTCGCATCCTCTATAGTTGAAGCTGGGGCAGGA ACAGGCTGNACCGNGTACCCTCCCTTAGCAGCCAACCTAGCCATGCAGGAGCTCATAGAT CTACCATTTCTCTTACCTTACAGAGNTTTCTCATTTAGAGCATCACTCATTCACATTATCAC TAAGCCCCGCATGCCATACCACCCTTGTTGAGAACGAATATACGCGACTCTCTACTTGTCT TTTGCGCGC >'990809A-021.scf came from CONTIG 8 at offset 9;"C:\export\EG_DB\990809a\990809A-

021.scf(61>617)

GCACGAGGCTCAACCAACCATAAAGATATTGGTTACCCTTTATCTACTATTTGGGTGCTTG GGCCGGGATAGGAGGAACAGCTCTAAACCTTCTAATTCGCGCTGAATTAGGCCAACCCGG AACTCTGCTCGGAGACGACCAAATCTACAACGTAGGTGTAACCGCACACGCATTTGTAAT AATCTTCTTCATAGTAATACCAATCATAATTGGGAGGATTCGGTAACTGACTTGTTCCCCT

AATAATTGGTGCTCCCGATATAGCATTTCCCCGAATAAATAATATAAGCTTCTGACTCCTC CCTCCCTCATTCCTACTACTCCTCGCATCCTCTATAGTTGAAGCTGGGGCAGGAACAGGCT NGACCGCGTACCCTCCCTTAGCAGCAACCTAGCCATGCAGGAGCTCATAGATCTACCTTTT TCTTTCACTAGCAGAGTTTCTGATTTTAGAGCATCACTCATACACAATATAACAAAGCCCC GCATGCCATACAACCCTCTGTGTGATCGTATATACGCGACTCTCTCTTGCTCTGTTGAGCG

GTACAGCTTA

>'990809A-006.scf came from CONTIG 9 at offset 0;"C:\export\EGJDB\990809a\990809A- 006.scf(51>493) TTGGAATTAGGCACGAGGACCCACATACCTTCAAAAGAAAACGAGGTGCTGACCTTGGCT

GTGCTCTTCCTGACGGGGAGCCAGGCTCGGCATTTTTGGCAGCAAGATGACCCCCAGTCAT CCTGGGATCGGGTGAAGGATTTTGCCACCGTGTATGTGGAAGCAATCAAGGATAGAGGCA GAGACTATGTGGCCCAATTCGAAGCCTCCGCTTTGGGAAAACAGCTCAACCTGAAACTCC TGGACAACTGGGACACCCTGGCCAGCACGTTGTCCAAAAGCGTGAACAGCTGGCCCAATG ACCCAGAGTTCTGGGACAACCTGGAAAAGAGACCGCGTCGCTGAGGCAGAGATGCCAGG

ACTGAAGGAGTGAAGAGAGGGCAGCCTACTGACGGTTCAGAGAAGGACGAGAGTGAGAT TACGCGAAGGGGGCGTGGCGGAGT

>*990809A-057.scf came from CONTIG 9 at offset 17;"C:\export\EG_DB\990809a\990809A- 057.scf(54>482)

GACAGGATCCCTTCAAGAGAAGCCGGGTGCTGACCTTGGCTGTGCTCTTCCTGACGGGGA GCCAGGCTCGGCATTTCTGGCAGCAAGATGACCCCCAGTCATCCTGGGATCGGGTGAAGG ATTTTGCCACCGTGTATGTGGAAGCAATCAAGGATAGTGGCAGAGACTATGTGGCCCAAT TCGAAGCCTCCGCTTTGGGAAAACAGCTCAACCTGAAACTCCTGGACAACTGGGACACCC TGGCCAGCACGTTGTCCAAAGTGCGTGAACAGCTGGGCCCAGTGACCCAGGAGTTCTGGG

ACAACCTGGAAAGGAGACCGCGGTCGCTGAGCAGGAGATGCACAGGACCTGGAGGAGTG AAGCAGAAGGCAGCCCTCCTGACGAGTTCCAGAGAGGGGACGAGAGTGGAGACTACCGC GAGGTGGNGCG >'990809A-066.scf came from CONTIG 10 at offset 0;"C:\export\EG_DB\990809a\990809A-

066.scf(62>596)

GCACGATGGCACTTCCTGGCACCTCTAGGTATTGCTGGTCAGGGGGGTGTGGGCGGCCTG CCTGGCCAGAGCAGGAGAAAGAGGCTTCCCTGGGCTTCGTGGGCCGTCTGGTGAACCCGG CAAACAAGGTGCTTTGGGAGCAAGGGGTGAACGTGGCCCCCCTGGCTCCCATGGGTCCCC CCTTGGATTTGGCTGTGTCCCCCCTGGCGAGTTCTGGACATTGTAGGGATCTCCCTGTGTG

CTGAATGCATCCCCTGGACGAATAGTTCTCCCCTGGCGCCAAGGGTGACCTCGGCTGAGA CCGTCCCTTCTGGTCCTCTTGTGCTTTTGGGGCTCCTGTGTCCCCGTTCCTGTTGTCCTGCCT GGTATGATTGTTTTCGTGTTTTCCGTGCCTTGTGTTCTGTGTTTCCTTTTCCCCTTTGGTCCG TGTCCCGCTTGCCCTAGTCCCCTGGTGAATGTGTGACAGGTACAGTCAAAAGCTTAAGGCC ACCTTTTCTCTGCTCATGTCCCCCCCCTCCGTTTCTGGTGTCAGTCT

>'990809A-093.scf came from CONTIG 10 at offset 5;"C:\export\EG_DB\990809a\990809A- 093.scf(56>547)

CTGGCACTCCTGGACCTCAAGGTATTGCTGGACAGGGTGGTGTGGGGCGGCCTGCCTGGT CAGAGAGGGAGAAAGAGGCTTCCCTGGGTACTTCCTGGGCCCCTCTGGCGAACCCGGCAA

ACAAGGTCCTTCTGGAGCAAGTGGGGAACGTGGCCCCCCTGGTCCCATGGGCCCCCCTGG ATTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTCCTGGGGCTGAAGGATCCCC TGCCGAGATGGCTCTCCTGGCGCCAGGGTGACCGNGGNGAGACCGGCCTGCTGACCTNCT GTGCTGCTGCGCTCCCGGGCCCCCGCCCTGTCGGACCTGCGCAGAGGNGATGTGGGAGAC GGGCTGTTGTCTGCTGTCCCATGCCCGTGTGCCCGGCCCCGTGACCCAGGCCCGGNGACA

GGNGGACAGGACAGGCACGAGAATAAGTNACGGCTGTTGTCTCAGAACCCGCCTTCGCTT

CTGGAGAGACCT >'990809A-037.scf came from CONTIG 11 at offset 0;"C:\export\EGJDB\990809a\990809A-

O37.scf(60>606)

GCACGAGGCCCGGCCCTCCTGGACCCCCTGGGTCCCCCAGATCCTCCCAGCGGCGGCGTA CGACTTGGAGCTTCCTGCCCCAACCACCTCAAGAGAAGGGTCACGATGGGGGGCCGCTAC TACCGGGGCTGATGATGCCAATGTGGTCCGTGACCGCGACCTCGAGGTGGACACCACCCT CAAGAGCCTGAGCCAGCAGATCGAGAACATCCGGAGCCCTGAAGGGAGACGCAAGAACC

CCGCCCGCACCTGCCGCGACCTCAAGATGTGCCACTCTGACTGGAAGAGCGGAGAATACT GGGTTGACCCCAACCAAAGGTGCAACCTGGATGCCATTAAGGGGTTTTGCACATGGGACC CGGGAGACCTGTGNTACCCCACTCAGCCACGTGCCCAGAGTACGTTATTCATCAGAACCC AGAAAAAGGACGCGGGGCGGGGAGATGACGCGGTGCATCGGGTTGGGGCAGGGTCGTCC TGCGTGGGCTCACTGCTTCTGGCTGTGGCCCGCGCTGCAACATACTACCTCAGAGGGGGCT

CTGTCCGG

>'990809A-092.scf came from CONTIG 12 at offset 0;"C:\export\EG_DB\990809a\990809A- 092.scf(61>533) GCACGAGGCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGGTTGCAAGGTCTCCCGGGT

CTTGCTGGTCATCATGGCGATCAAGGTGCTCCCGGGGCTGTGGGTTCCCGCTGGTCCCAGG GGCCCTGCTGGTCCTTCTGGCCCCGCTGGCAAAGACGGGCGCATTGGACAGCCTGGTGCA GGCGGACCTGCTGGCATTCGTGGCTCTCAGGGAGCCAAGGGCCTGCTGGCCCTCCTGGGC CCCCTGGCCCTCCTGGACCCCCTGGCCCAAGGGNGGGGGTACGAGGTTGGTTTGATGGAG ACTTCTACAGGGCGCCAGCCCGCTCACAACTTCTTCAACCCAGGATATGAAGTGTGCTCTC

TGATATCTCACAACAATGAGACCTTCTCTCAAGGATTAGAGAACCACCGCCAGCGGACTG AACCACCCCCACAGACAGGGTCTCTGTTGACTACAGAGACTTGAGCTTAAA

>'990809A-013.scf came from CONTIG 13 at offset 0;"C:\export\EG_DB\990809a\990809A- 013.scf(55>581)

CTTTACCCAGCCTATCTCAGAAGTTGTAGATGAAGTAATTCAGAATTGTCCTATCGATGTC AGACGTCCTCTCTACAAGAATATTGTGCCTCTCTGGAGGTTCAACCATGTTCAGGGACTTT GGACGTCGGTTGCAAAGAGATTTGAAAAGAACTGTAGATGCCAGGCTGAAATTAAAGAG GAATTGAGGGGTGGTAGATTGAAGCCAAAACCTATTGATGTACAAGCCATTACACATCAC ATGCAACGATACGCAGCTTGGTTTGGAGGATCTATGCTGGCTTCCACACCTGCGTTCTACC

AAGCATGCCACACCAAAAAGGATTATGAAGAAATTGGACCTAGCTTCGTCGCCACATCCA GCGCTTGGGTCATGTCGCAAAATGGCTTCATAGTTTGGGGTAGGGGGGGAGGAGAAAAGA CTTCTGTTACCTGCTGCTGGTGGCTGCTGGCACCTGACTGATCATAGACAACATCATATCA GATATTtATAGATACACAGCGAAGAAGAGGCAAAGATAGNGTTT

>'990809A-O10.scf came from CONTIG 14 at offset 0;"C:\export\EG_DB\990809a\990809A- 01 .scf(47>589)

TTGTTAAAGTGGCCTACAGCACCGAGGGCGCCAATTCCAGTTCATCCAGGTTGCAGGGCG GGCAGGAGATAAGATATTTATAGGTAATGTGAACAACAGCGGCCTGAAGATTAACCTGTT TGATACCCCCTTGGAGACGCAGGATGTGAGACTGGTACCCATCATCTGCCACCGGGGCTG

CACCCTCCGCTTTGAACTCCTTGGCTGGGGAGTTGAATGGATGCACTGAACCCCTAGGCCT GAAGGATAATACCATCCCCAACAAGCAGATCACAGCCTCCAGCTACTACAAAACCTGGGG CCTGAGTGCCTTTAGCTGGTTTCCCTACTACGCACGACTGGATATCAGGGCAGTTCAACGC CTGACCGNCCACACCAACAGGCCTCTGAGTGCTGAGATGACCTGGCTCCAGAGCGGTCAC GGCATATCACCAGGGCCCGGACTTGCCCATCATTGTGCTGCTCAGGGGCTTGNGTGTGNG

GACCGCTGGACAGACCGGGCCCAGAGAGATTTCTGTACTGACATATCCAAAAGAAATTGA C

>'990809A-002.scf came from CONTIG 15 at offset 0;"C:\export\EG_DB\990809a\990809A- 002.scf(52>545)

TTGTTTTGGTTTCTTTGAATTCCTAGAGACACAGATTCTGATAGAGAAAATTATATTAAGT TATAGAAAACTTTACAGGATAATAGCTTTATATTCATTGCACACTTACCTTGAATAGTCAT GGCGTTATCATAGTATCATTAGTATAGTTATCTGTATTCATTAATTGGCATTTTATGGGTTT CAGGTAGACATGACATGACATGACTCTAACAAAATTAAAAGAAGTAGGGCTTGTTCTTTT ACGAATTATAGTTTTATTTTCCTTCTTGGTATATAAGAATTTGTTAAGCCAGCATATT^ TTTATTTGTGCAGATGCTGNTAATGTCTGGATAACTATCTTTACTTTATGGGGGGTAAATA TGTGTTTTGGGTGATGTGTGGCAGCCACTGGTATGTGTGTATCTGGTCCCATTTACAGTAG ACACATTCTCTGTTTTGTACTTCACAGCTAAATTTTTGGTTATTTCTTACCACTGCTNCCAN ATTA

>'990809A-012.scf came from CONTIG 16 at offset 0;"C:\export\EG_DB\990809a\990809A-

012.scf(54>607)

TTAACACCTACAAACCTTCCAACTCCCCACTCTACGCAAAAACAGCTATCTCATACGCCCT CATTACCAGCATAATTCCCACAATAATATTTATAACACTGAGGGCAAAAACTAATTATTTC

AAACTGACACTGACTAACCATGCAAACTCTTAAATTATACCTCAACTTTAAAATAGACTAT TTTTGAATAATATTTATCCCAATTGCGCTATTGGTCACATGATCTATTATAGAATTCTTAAT ATGATTTATATACTCAGACCCCAATATTAACAAAATGTTCAAATATCTTCTCCTATTCCTCA TTTCTTTGCGTGTCCTTGTTACCGCAAACAACCTCTTGCGGGTTTGATTGGCTGAGGAGAG TGGGATATATCTTTTTGCTCATCGGTGATGATGCGGCGAGGAGAGCAAAACGGAGGCGTC

AGCATGCTGTTATCGGTCGGGCGTTGTTGTTGTGNGTAGATGTTCGTAAATTCAGTCCGGA CGGCACGATCTTTCTTACCAACACCAACTCCTGGTGTCTGCTGTTGACGGTATCGACATTG GCTC >'990809A-008.scf came from CONTIG 17 at offset 0;"C:\export\EG_DB\990809a\990809A-

008.scf(61>623)

GCACGAGGAGAATCTTTTAAACCAAAATAATGCAGCAGGAGATGCCTGTGTTCCAGGTGC ATTGAAAGCCAATGAGAAGTTATCTGAAGAGAGAGCACAAGATACATACTGTGATGGTTC ACCTTTACCTGAAGATTTTACAGAGTCTACCAAAATGAATGGCTGTGAAGAACATTGTGA AGAAAAAGGTAAAAGTGAAAGCTTAATTCAAAAGACAGAAGAAAAGAAGACTGAGGATG

ATGAAATAACATGGGGAAGTGATGAATTGCCAATAGAAACAACAGACCATGAAGATTCC AATAAAGAGCATCCCTTTCTGACAAATGAGGAACTCACCACACTCCCCATCATCAAAGTG CTTCCCTCCGCGAGTACACTGCTGGCCAGCTGCAGTCAGNCATGCGGTGTTGCGGGGNNT ACTCGATCAGGGATCCATCTAGGAGCTGGAGAATCTCAAGAATAAAACTTTGATCATGTC TATTGACAGACGAGGAAACAGAGGAGAACGAATAAATATACGCCCTGACGCTCGGNGCC

TCTGGGTGAGGGGNTTTCACGCGCTC

>'990809A-048.scf came from CONTIG 18 at offset 0;"C:\export\EG_DB\990809a\990809A- 048.scf(62>553) GCACGAGGGGGGGCTCAGTCCGCAACCGCCGCCGCCGCGCCTCCGTATCGGTGCTGGGAG

GGGCCGCCGCCGAGACAGCCGTGCGGGCGAGCATCCCCAGGCAGCACATTAAGAGTGGG TGATAGCGGTGTCCCGCCCTCACCGAATACATCCCGTTCTGCACATATGCACTGGGAGGGC CTTCCAGCTATAAAGTAGGCACCATGGCTGAGAAGGTCGACTGCCACTACTGCAGAGACA ACCTGCGAGGGGAAGAAGTAACGTGCAGAAAGACGGCCACCACTGCTGCCTCAAGTGCTT CGACTAGTTCTGCGCCAACAGNTGTGTGGCAGTGCCCGCAGCCCATCGGCGCCGACTCCT

AGGAGTGCACTACAGGAACCGCTACTTGCACCAACCTGCTTGCGCTGTTTTAGTGCTCCGC CCTTGGCAGAGAGACTTCGTGACAAGAAACAGATCCTGGCACAGGCCCCTCGGAGACAAC CCAGGCTGGCT >'990809A-049.scf came from CONTIG 19 at offset 0;"C:\export\EG_DB\990809a\990809A-

049.scf(62>438)

GCACGAGGGATTAAAGGTCTGGAAACACATAAATGGATTGCAATGAACTTTCCAGATGTA GTAGTTCATGGGGATTCTCACGGCAACAGTCGACTCATTGGAAAAGACCCTGAGACTGGG AAATATTCAAGGCAGAAGGAGAAGAGGGGGACAGAGGATGGAGATGGGGGGGAGGCAT CACCGAGTCAATGGATATGAACTTGGGCAGACTCCGGAGATGGCAAACTCCGACCGTCTG

CAGGCCATGGGGTGGCGAGAGGCGGCACATTTGGGGACGGACAACACCAACAAAGATAT TTGGAGCCACTTTTAAATTTTAATGATGCTCAGGTCATTAGTATGTGCTAAATTGAGGTCC CAGTTACCCAATGGCGGGG >'990809A-009.scf came from CONTIG 20 at offset 0;"C:\export\EG_DB\990809a\990809A-

009.scf(51>605)

TATGAGAGCAGCACCTTCCCCCTCCTCCTTTCCACACCTGCAAACTCTTTTGCTTGGGCTGA ATATTTAGTGTAATTACATCTCAGCTTTGAGGGGCTCCAGAGGCAAATCCCCGGATTAAAA GGTTCCTCGGTTGTGAAAATATACAAGAGAAATCATGAAGGCAACTATCATCTTTCTCTTG GTTGCACAAGTTΓCCTGGGCTGGACCATTTCAACAGAAAGGCTTATTTGACTTTATGCTGG AAGATGAGGCTTCTGGGATAGGCCCGGAAGAGCACTTTCCTGAAGATCCTGAAATAGAGC

CTATGGGCCCAGTCTGCCCCTTCCGCTGTCAGTGCCATCTGCGAGTTGTCCAGTGTTCTGA TCTGGGTCTGGAAAATACCAAAAGACCTCCTCCGCTACTGCGCTGCGGACCGCAAAACAC AAAATACTGAGACAAAGATGAGACTTAGAACTGAGACCTCTACACTGTTCNATCACAACA

AATAGCAAACAGCCTGGGCTTGCTCTTGGTGAATGGACACTATCTTCCAGATAACGAGGA TGCAGAAAA

>'990809A-028.scf came from CONTIG 21 at offset 0;"C:\export\EG_DB\990809a\990809A- 028.scf(61>564)

GCACGAGGCAACCACGTGCTGAAGGGCAAGGACGCCAGCTGCCTGGCAGAACAGTGGGT CTGGCAAGAAGGGGGGACACAGGCCGCCCTGGGGGAGCAAGAAATCCAAGAAGAAGAG CGGCCGGGCCAAGGGCTTGGGCGGGGGCAGCAGGAAACAGAGGAAGGAGCTGGGCGACC TCGACGGAGACCCCAGCCCCGAGGAGGACGAGGGCATCCAGAAGGCTTCCCCGCTCACAC ACAGCCCCCCTGACGAGCTCTGAGCCTAACCCAGTGGCTTTTGCTGACTGAGAGCCTGAG

CTGGGAGCCCAGGTGTCTGGGCCCCCGGGCTGCACAGATGGAGCAGCGCAGGCCTCAGCG GTGCCTGCCTGGCCGTGCCGCCTCCTGCCGTGGAACTCCAGCCTGGGGNAACTTNATCAGT TCGGGCAGGCGGCTGCCTTTCCTCTGCCCAGCGTCTTCCTGACCAACTCAGCGGGCCCAGA TTCAGATGCCAGACTCATGTGACTCG

>'990809A-024.scf came from CONTIG 22 at offset 0;"C:\export\EG_DB\990809a\990809A- 024.scf(53>501)

TTTCAGCCATCCCTTGGGTTGAAGACAAGCTCACCAACTCCCCACACGCCCACCACCCCCC TACCCAACTGGGCAGCCCTTCAACGAGGATGGTATCGAGGGACTGAAACATCTTACCTGT TCCTGTCTGTCTGGCCGCAGGGTCTAGGAGCCCCCAGGACACAGCATGAGTGGGCCTTGG

ACCGCTACCCCGCTATGGGCCTGCAGACTTGGTTCCAAAGGCCTGGGCGGACAGACCGCC CAGTCACCACCTTCACCCTAGCTTGGCCACCCCAGGGCGACAAAGAGCAGCAGGGGGCGG GGGCAGCCGCGCGGACAAAGCCGGATTTCCTGGTCGCGGCTGGCTCTGTTTCCCTGCGCTC CCCCCCCGCCGTGTGTTCCGCCGAGCTGACGTCTAACGGGGAGGGTAGAAGGACAACCCG CAAGGTGTGGGATTGAAGGAATGTGGC

>'990809A-020.scf came from CONTIG 23 at offset 0;"C:\export\EG_DB\990809a\990809A-

020.scf(58>610)

GCACGAGGGTCAGTGTTAGCATCAACACCACGCTCCCATCTACCATTGAGCCTTGCATCTT GCCATCCCCATGGCAAGGAAGCCTTTCTCTGCTCAGATTCCTCCTACCCTTGAAGACTTAG

CTCAAAATGCAACACCTGTATCTGCTTCAGCTCATCCTATCTTCTCAACTCCCTTATATGTT TGTACTTCTTACTTGAATACTTAATCCTATATGCTGGTGAGGGTTACTGAGTCTCTTCTATG TCTCAGTCATGTCTTATCAACAAAGCTGCAAACTTACCAAGAGACAGATCACTTCCACTCC CCAGGGTGCCTATCACAGGTTTTAGTAGCAGAGAGGAGCTCAAATCCACTGTTGATTTCAT CTTTGTTCCATTTGCTATTATCAGTTCATTTAACAAAGAGNAGTATGCTCTATACCTGCTTT

TCAAAAGAAACTAAATCAGAAATATTATAAACAGAGAAGGTCATCTGTTGCTCTTGGCAG AGCCTGACAGNCNTAAACGAAAGCTCANGTCCCAGGAACATGGCCACGGTCGGGGGAGC GTCT >'990809A-025.scf came from CONTIG 24 at offset 0;"C:\export\EG_DB\990809a\990809A-

025.scf(55>597)

GGAAGATGTATGGAGACATGGCCTAAAGCCAGAGACAGGGAGAACACGTGAACATTTTA GGCTGTCACTTGAATCGATTCACATCTCATTTTTGTGTACACGTGATTTCAGGGGCACAAG TTATTTAAATCTGTGCTTCTAACTGGGGAAAAGAAAAATTCCCACCAAATTCAAAATACTG TGCCATGTGATATTCAAACCAATAGTCCGCCAACCCCAGACACTGGTTTGAAGAAATTGA

GACTTGATCATAGGACTGTATTAGTGCACAGCGCCAGCATGTATGCTAGGAGCAGGGGAG GAGGGCAGCAGAAAGCCTTGTATCTTTGGGGGGGNGGAGTGACTGGTTTTGGATGTGACT GAAAAGAAAACTTAGCATGCTCCTGTCTGCCTTAGCTCCAGCACGCCGGTGTGCGCCCCA CCTCAGAGCGAGCAGTCGCTCTAGCAGACACAATCACTTGACTTTGATCAGACATGTCAG AATAGATCTGCTTAACGACGCCGGCAGCGATGCCCACAGCAATNTTTTGTACGAATTGGG

NN

>'990809A-026.scf came from CONTIG 25 at offset 0;"C:\export\EG_DB\990809a\990809A- 026.scf(57>601) AGGAACGAGGCCCAGCTCTATGTAGGCAGGGCGGGGTGGAGCTCACCTGCTCCCATGCTC TGGATGGACAGCAACTACTCTACGGGGACCAGGGGCACAAGACTCAGCAACTGGACCAC CAGGCACCCCCCCAACCCAGAGGGGCTGGAGTTGGGTCCTGAGGGTTCCCAGGACCAACG GCTGCAAAAACCGGATGTTACAGGAAGGAGGCCTGCCTCCTCAGGGCCTCAGATTCTGAA ATGCCCAGAGGGAGAGGGTGTCAAGCTGCGCTGTGAGCTGGGGGCACGGACCGGGAGAG

AGCGCGAATCTGCAACTGCGTTGCGCGTGTGGGCCAAAACCCTCTACAGCGGGAGCACCA GCCTTTAGACGGAGAGTGAGGCGGGATGAGCCCCGAAAGCACTATAAAACTGCTCGACG GTTCCAGAGAGCTGCAGGGGCCAGGGGCAAGGACAAGGAGAGCAGCCCGGTGCTCTTGA TCTATCTATCTGCCATGCCTCCGTCCGTCGCCTTTTACTTAAAATGATTTTAAGCTCGTCGC GGCGNCT

>'990809A-022.scf came from CONTIG 26 at offset 0;"C:\export\EGJDB\990809a\990809A-

022.scf'(60>522)

GCACGAGGCTCCCTGTGGATCCTGTTCCACTTCCTGACGGGGCAAGGCAGGTCAGGAAGG TGTAGACCATCCTCAGGAAAGAGCCAAGGCCCAGGAAGTCCTCCAAGCCATCCGGGGGCT

TCGTCCGCTTCTTCTTCGGGTGGCGAGAGGGCGCTGGCCACTTTGGGCAGATGGCCTCTGG CTCCATGCACCGGGTGGGGAGGCTGAACAGCGCCGTCCTTTGGGTCTGGGCCAACCACAA CAAGGTGAACGCTCGCCTCGCAGGCGCCCCCAGCGAGGACCCCCAGGTCCCCAAGAGGCA GNGGCCACCCCGCGAGCTCTGGTCCGCCTGCCACAATGAACTACGGGCACGCCTGTGTGG GACCTGCACAACATCTCAGATCTTGAGACCACTACTCCCCAGCAAAACTGCTATACTTTCT

TTGCTGGCCGGGGCCGGGCGGGGGAGGAGGAGGAGGAAACA

>'990809A-003.scf came from CONTIG 27 at offset 0;"C:\export\EG_DB\990809a\990809A- 003.scf(l>516) CCTCTCGGGGGGGCCGCTTAAATGGGTCCCCGGGTTTTTGCCGGGCATTTACCCTTCAGAA

AACGAGACCACCAATTCCTTTCTTTCCCGGCTGGGGACCAGCCAGNGTTCCTGCCCACCCA GATGCTGGTGAAGATCATGGCAGATATTGCCAGAGGCATGGAGTATCTGAGTACCAAGAG ATTCATACACCGGGACCTGGCTGCTAGGAATTGCATGCTGAATGAGAACATGTCGGTGTG GTGTGGCTGACTTTGGGCTCTCCAAGAAGATCTACAACGGGGACTACTACCGGCAGGGAC GCATCGCCAAGATGCCGGNCAAGTGGATTGGCATCGAGAGCCTGGCGGACCGTGTCTATC

CAGCAGAGCGATGTTGGGGCTTGGGTGACGATGTGGAGATGGCAGCGAGGCAACCCCTAT CAGNATGGAGACAGGAGATATGATACTGGCCAGGAACGCTGAGCACCGTGACTGCTGAC GACGACGCCGTGTCGTGCTGGGCTAACCCCGACGC >'990809A-001.scf came from CONTIG 28 at offset 0;"C:\export\EG_DB\990809a\990809A-

001.scf(62>533)

GCACGAGGCTACCAGTATGGATTCAACCTGGTCATGTCCCATCCTCATGCTGTCAATGAGA TTGCGCTGAGTCTCAACAACAAGAATCCAAGGACCAAAGCCCTTGTCTTAGAGCTCCTGG CAGCTGTGTGTTTGGTACGAGGAGGGCACGAAATCATTCTCGCTGCCTTTGACAATTTCAA AGAGGTGTGCAAGGAGCTGCACCGCTTTGAGAAGCTGATGGAGTATTTCCGGAATGAGGA

CAGCAACATCGACTTCATGGTGGCCTGCATGCAGTTTATCAACTCGGGGGTGCACTCAGTG GAAGACATGAACTTTCGGGTCCACCTGCAGTTGAGTTCACAAAGCTGGGCTGGAGGAGTT CTGCAGAGTCACGCACCAGAGAGGGGAGCGCAGCGCAGATCAGGCGACCTGACACGGTC GTGTGGGGGGTGTGGGGTGCGGACAAAAGTGGCCTGGAAGGGAGAGTGGG

>'990809A-004.scf came from CONTIG 29 at offset 0;"C:\export\EG_DB\990809a\990809A- 004.scf(50>557)

TTTGCAAGAGAGAAGACAAAGCAAATGAACTCAAAGACAAGATGGGCAAGTGGAGAGAT GATGGGGAAGGATTGGGGAGCTTTGTTCTGCTGGCTCCTCTGGTCTCAGAAATGAGAATT ATAATTCCATTCAACAATGAGAATGGACAGCAGACATTGGGAAGGGAGTGAGTGACTGAT

TAGATGAGGGGCACAAATTGGAGATGCCCAGAAACACTAAGTTTCCTCTTAAGTTACTGG CCTTGAATTTCAGTGGTAGCCAGCCACTAGAGTGGAGTTTTATTCTCTATCCTTATTCAGCT GGGAAGCTGGGGGTTTGGGTTGAAAGAGTTGAATTTATCTAGGTTGTGACTTTGCCAGCA GATGTAGCCACCAATGAGAGAGAGCAAATATGCCAATAGAAGCTTACTTNTTCTGNAGCC CGNGGNCTCTGGATGCTACTGTTCATAGATAACCGCAGCAGAAAGGGAACCGCCCCGTAC

AGGAGCTGGACGAATATGCTCCGTCAC

>'990809A-007.scf came from CONTIG 30 at offset 0;"C:\export\EG_DB\990809a\990809A- 007.scf(52>536) TGGCCGGCTCCCGCGGCGGCTCCCGCGGCGGGCTCCCTAGGTTAGTGTGATCTCAACTCAA.

GAGAAAGGTGGGGCTATCATGGCATCTATCTGGGTTGGGAAAGCGAGGGACAATAAGAG

ATTATGCTGGCTTTAACCCATCGGGGGATGCTGAAGCGATTCGTAAGGCCATCAGAGGGA

ATTGGGGACCGACGAGAAAACACTGATCAGCATTCTGACTGAGAGGACGAATGCACAGC

GGCTGCTGATTGCTAAGGAATATCAAGCACTATGTGGAAAGGAACTGAAAGATGACTTGA

AGGGTGATCTCTCTGGCCACTTCAAGCATCTCATGGTAGCCCTCGCCGCCCCACCCGCAGN

GTTCGCTGCGAAACAGCTGAGAATCCATGAGGGCATGGGACAATGAGATGCACGATCGA

AATCTACCACTGACAGCAGCAATGCAGAGACGGCATCCTCTTCACGACAGAGGACTGAGA

TGGATA

>'990809A-030.scf came from CONTIG 31 at offset 0;"C:\export\EG_DB\990809a\990809A- 030.scf(48>602)

TTTGTGGCAGGATGGGCAAGTGTTGCGGTCTTCGTACTGCCAGGAAGCTCCGCAGCCACC GACGAGACCAGAAGTGGGATGATAAGCAGTACAAGAAAGCCCATCTGGGCACAGGCCTG AAGGCCAACCCTTTTGGGGGCGCTTCTCACGCTAAGGGAATTGTGCTGGAAAAAGTAGGA

GTTGAAGCCAAACAGCCAAATTCTGCAATCAGGAAGTGTGTCAGGGTTCAGCTAATCAAG AATGGCAAAAAGATCACTGCTTTTGTTTCCAATGATGGGTGCTTGAATTTTATTTGAGAAA ATGATGAAGTTCTGGTTGGTGGATTTGGTCGCAAAGGTTATGCTGGTGGTGACATTCCTGG GGTCGTTTTAGGTTGGAAAATAGTCATTGTΓI TTTTTGGTTATCAAAGCAAGAGGAAAGA CAAATATAAATTTGTGATGAAGACGATGAATAATTTTTTTACAAAAAAAAAAAATGGGGG

GGCCGGCCCATTGCTTTTGGGTTGTTTATTATGGCGGGTTAACGGGATGGAAACTGGGTCC ACTΠTGTTGCG

>'990809A-031.scf came from CONTIG 32 at offset 0; "C:\export\EG_DB\990809a\990809A- 031.scf(l>545)

ACCACGGGGGGCGTTAAACTAGGGATCCCCCGGCTGAGAATGGCACGAGGGACATTCTAC CCTGGCCGCTGACTCGGGAACCTCAATAACCAAACCAGCCGATTCAAGGGGCCAGGGCTT TGGTGGGGCACCCGATCCCACGGGCTGACCACCACCCCCTCACGGAAGCCTCTTACGAGA ACCTGCCCACCATTGCCCTGGGCAACACGGACTCTCCTCTGTGCTATCGGGACATCGGCAC CCCGCGCCACAACAAGGGGGCGCACTAGGGGGGGTGGGTGGCGGGTGCTCGCCCGGGGA

AGTCACGCGCATGCGGGGCACCATCTCCCCGCGCCCCGGGGGAGGGTGTCCGCCTCTCTT GTCAGAGAGCTGAGAGAAGAAAAGAAGAAGGGAGCAGAGAGAGCTGGGCCAGAGGGTT TGGGTTGATGGTTGCTCQCTTCTATTTGGCTGGATGCGAGGGACACGCCTGAGGGCGCGCT CCGGCATCAGGGCGACTAGAGGAGCGAGCTCCCTGAACGCGCGCCACGACACCCGAGGA GAACACC

>'990809A-035.scf came from CONTIG 33 at offset 0;"C:\export\EGJDB\990809a\990809A-

035.scf(13>36)

AGGCGGCCGCTCTATGATACTATT

>'990809A-O33.scf came from CONTIG 34 at offset 0;"C:\export\EG_DB\990809a\990809A- 033.scf(61>588)

GCACGAGGCCCAAAGACACTGAAGTTTTCTGGAACAATGGCAGAAGTTGGGTTTGAGAGG AGGAGTGTTCTGTCTTAAAGCATGTGGACCAGAGGTCAGTAGATGATAGAAACATGTAAG TGTACATAGTAGTATTGTCAGATGTCAAAGATGCCAGGATGGAGGCTGGGTGGGGTCTAA

AGTGGCATTAATGGGTTAATAAATTGTCACCCCTATCCTCAGTTCTATGGTAGGTGAAATG TACAGTTAGTGTGGGGAGATGTTGTGTTTATTGGGTCTITTTCTTTTACATAAAGATGAAG ATCCACAGGGTTGTATGGGTTGAGGGAGAGAGACAGAGAGAAGAGGTACAGAGCTGAAG GGTTGAGACAGGGAGGNAACTGACTCCTTTGGCTATAGATATAGGACGAACCCTATTGAT TATTACCCAACATCAAGNNGATAGCAACAAAAGCGGCGGGGGGGCCGCCACAGGTGGGA

CCATGCTGGCTGGCATAAATTAACAGCCCCTCGGCGAGGGACGGCCTN

>'990809A-040.scf came from CONTIG 35 at offset 0;"C:\export\EG_DB\990809a\990809A- 040.scf(60>587) GCACGAGGGTGGGGTCCCCCTGGGGGTGGGGGGCGGGAGACATCTGGGCATCCAGCCCC

CCCAGGTCCTCTTACTCTCTCTCTCCTTTCCTCCATCCACAGGTGATAGTGAGGTGCGGAA GCTGGAGGTGGCGCTGGGCGTACATCTTCGAGATGCCAGGCGTGGGCAGAGGCTCCGCTC AGGGGCGCACGGGGTGGTTGCGGGACCTCCCAACGCCGGCAAAAGCAGCCTGGTGAACC TGCTCAGGGGTGGGGCGGGGGCGGGGCTAGGGGCAGGGGCGGGGCTGGAGCTAAGCTGC TGGGCTTGTGGGGTAGGGAGGGGCCTGGGAGGGTGAAAACTGGCCGGGCCGGGGGGGGC CTAGGGAGGGACCCTCCATTCCACCACCGCTCCTCTGGCCACCCCACCCCGGCCGGAGCT GGTCATCGGGCCCGAGCGGGACACCGGAGTCTGGACCCGGGACTGGCGATTCACGCTGTG GGACATGGGGTGGGAGGGGGGCTGGGCGGGGGGCGGGCCAAAGAGGAGCGA

>'990809A-036.scf came from CONTIG 36 at offset 0;"C:\export\EG_DB\990809a\990809A- 036.scf(55>584)

CTCCCCCCGAGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCTCCGGGCTCCTGCTAAG CCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTACCGGGACCTCATTAGC CATGACGAGATGTTCTCCGACATCTACAAGATCCGGGGGGGGGCGGACGGGCTGTGTCTG

GAGGTGGAGGGGAAGATGGGCAGAAGGACAGAGGGGAACATCGATGACTCGCTCATTGG TGGAAATGCCTCCGCTGAAGGCCCCGGGGCGAAGGTGCCGAAAGCACAGAATCACTGGG TGCNGTGTTGTCTTGAACCATCACTTGCAGGAAACCAGCTTACAAAAGAGCCTACACGAG TACTAAAAGATACATGAAGGAATCAATGGAAACTGTACACACAGACAGAAGAGAAAACC TTTTGACGGGGCTGAGACAAATCAGCACATCTGCTATTTAAAATATATTTTTTTGTGAAAC

ATGATCAATGCGGGTGGTTGTGGCTACGGAGGTGGGNANCCATTTGATTT

>*990809A-038.scf came from CONTIG 37 at offset 0;"C:\export\EG_DB\990809a\990809A- 038.scf(54>610) CAGCAACCGGCCTGCCTTCATGCCCTCCGAGGGCAAGATGGTGTCGGACATCAACAACGG

CTGGCAGCACCTGGAGCAGGCCGAGAAGGGCTACGAGGAGTGGCTGCTGAACGAGATCC GCCGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACG AGGCCTGGACCGATGGGAAGGAGGCCATGCTGAAGCACCGGGACTATGAGACGGCCACC CTGTCGGACATCAAGGCCCTCATCCGCAAGCACGAAGCCTTCGAGAGCGACCTGGCCGCC CACCAGGACCGCGTGGAGCAGATTGCCGCCATCGCCCCAGAGCTCAACGAGCTGGATTAC

TACGACTCCCACACGTCAACACGCGCTGCCAGAAGATCTGTGACCAGTGGGACGCCCTGG CTCTCTTCCCACAGNCGCAGGGAGCCCCTGAGANAACGAGAGCAGCTGAGACATCGACAG CTGCACTGGAGTCGCCAGCGGGCGCCCCTCACACTGGATGANGNGCATGGAGACTCAGAC AGTCATCGCCCACATCAGN

>'990809A-042.scf came from CONTIG 38 at offset 0;"C:\export\EG_DB\990809a\990809A- 042.scf(54>549)

CAAAATTCTGAAAGCTGAATTTGTTACATAGTCTCAGTGAGCTCTTAACAGAATAGTGTAT GTTATTTGGGGGGAAAAGCAAACCTGAAAGGATTTTTCATGAATACTTCTTAAGCTTAAAT TATTTATTTGTCTATGTCCAGGCTTAGTTGTAGCATGCGGGATCATTCATTGGTTGGTGTGC

GTGGGCTTCTGTCTAGTTGTGGCATGTGGGTTCAATAATTGTGGTGCACAGGCTTAGTTAC CCAGGAGTTGTGGATCTTAGTTTCCTGATCAGGGATTGAACCTGCGTGCCCTGCATTGAAG GTGGATTCTCGACTGCTGGACCACCAGGGAGTCCCTACTGAAATATTTTGTATTAAATAAA AGGGTTGGCTGGGTTCCCTCTGCAGGGCCCAGGCATCAATTACAAGACAGCGCGGGGNGG GGCTGGGGCGGCGGGGGGGCGGAGTGAGGACAGTTAGCTGGAGGAGTTTGGATGGGGGG

GGGGCGCGGA

>'990809A-039.scf came from CONTIG 39 at offset 0;"C:\export\EGJDB\990809a\990809A- 039.scf(53>591) TTCTCCTCGGGCATCACGGGCTGCATCAAGAACCTGGTGCTGCACTCCGCCCGGCCCGGCG

GCCCGCCCCCGCAGCCAGTAGACATGCAGCACCGTGCCCAGGCAGGGGCCAACACACGCC CCTGCCCCTCGTAGGCCCTGCCTGCCCCGCACGGACTCCTGGGCCGCACCCCAGCCCCGCA ACGGCGACTATATTATTATTAATATTATTATGATGATGATGATGAATATTTTGTAAGAAAC CGAGGCGATGCCACGCTTTGCTGCTACTGCCCTGGGCTGGACTGGAGGGTGGGCACGTCA CGCCCTCCCGCCCCCACCCACAAACACACCTGGGCAGAGCCACAGGCTGTGGGCACAGCA

GGTTGCACCAGAGCCGTGCCTCGGGGGCCACCAGACACGGGTTAGGCGCAGTGGCTCATG GGTCAGACCGCCCCACACAGACCCCCCAGCAGGCTGCCGNCGTTGTCAGCTGGGCGGGCC CTATTCTGGAGCGCATGCTCACCGCCCTGCAGCACTGAACCACAAACCGGAGAGGA >'990809A-045.scf came from CONTIG 40 at offset 0;"C:\export\EG_DB\990809a\990809A-

045.scf(61>588)

GCACGAGGTGGAGAAGGGGGCAGACCTCAAGTGGGGGAGCCACCTGGGCTGAGGTGCCT GGGCCAAGTTAGACCTTGGGCCTGAAGGCTTCTGGTGGGTAGCCGGCCCCCTCCCCACTG AAGCACCGAGCTCTAAGAAGTCAAACACGTGTTGACTCATTTGTTGGAGAAATTCAGCTC ATGGGCTTCCTGCATTCCAGGGTGCTGGTATGCCAGAAATTCTCTGGAGGAGCAAGCAGG GAAGTCTTGTCTTAAAGTAAAAATGCTAATAAAACATCTCTAGAATCTGCTCCTTCCTTTT CACCCACACAGCCACTGACTAAATTACCTTTTGTTCTCATTTGCTGAATTGCCTTGGCTGCT TAATTGGCTTCNCTGTTTTTGGTTTCTNCACACCCACTTCATCTGTCCTCCAATGGGTTCAG ATGATATTAAAATGCANACTGCCACGTTCTGCCTTGGTTNCCCCACGCTGCAGATGAGGCA

GATGCTAGTGGGCCTCTGGACCTCAGAACTTGGGCTNATGAGG

>'990809A-053.scf came from CONTIG 41 at offset 0;"C:\export\EGJDB\990809a\990809A- 053.scf(55>485) CAAAATTGACCTTAAACAAGGAAAGTTTGAAGTCACCATCTTTGACTTGGGAGGTGGAAA

AAGAATTCGAGGAATCTGGAAGAATTACTATGCTGAGTCCTATGGGGTAATATTTGTTGTG GATTCAAGTGATGAAGAAAGAATGGAGGAAACAAAAGAGACAATGTCAGAAGTGCTGTG ACACCCTCGGATATCCGGAAAGCCTATATTGGTGTTGGCAAATAAACAGGATAAGGGAGG GGGCTCTAGGAGAAGCTGATGTGATTGAGTGGTGTTTTTCTGGAAAGCTCGACATGAGCA CACGTGCTGTGTTAGATAAACCCTGTGTGCAGACTGGGATATGGAAAGAAAATGACATGT

TCATTAAAAGGGCTTTTTTGGTTCTACTTTATTGCAGGGGCTTGTTGCCTTAAGAACGCTCC AAAAACACA

>'990809A-046.scf came from CONTIG 42 at offset 0;"C:\export\EGJDB\990809a\990809A- 046.scf(53>593)

TGAGACATTCCCATGTTTCGGAGGATTTACAGACAGGAGGATTCGCTCACCCTCACATCTA GCAGGTTTTTGTAAACGTGACCCTTGGCTGCATCTCCCATCTTCAGCACAGCTCAAGCACC CCAAACGTGTCCTTTCTCCCCCATAGACTGACAGGTGGGATCAGCTCCCCGGTAACCTTCT CTCCCTTCTCCATCTTCTCCCACACCTTGTCCATCCATAAAAAGCAGATTTTGGGGGTCCTT CCACGCCTTCTCCCTTTCTTTGTGTCTTTTTTTTAAGTGATATTTTTAGA

ATACCAAGGATTAATGTCTGCCCCTCTGCGACCTCTCTTCACCTCTTTTTCATAAAGCTGCT CTlTATGTTGCTTACATGCCTTATATATGTTTGTGAAGATATATATTGAGAGTATTGTATAT ATTATATATTTTTGTTGGACATCGATCCTTCTGAACTCTGCCAGCCGNTTCTCTCTTCCTTC ACATATCAGCAACGCGCCATACCCAGCCTNGAGCAANGGGGGAGAGNA

>'990809A-044.scf came from CONTIG 43 at offset 0; "C:\export\EGJDB\990809a\990809A- 044.scf(59>584)

GCACGAGGGGCATGTTGCGCGCCGTTGCGCTTGCCGCCGCCCGCCTCGGACCCCGCCAGG GCCGCCGCCTGCTGTCCGCCGCCACCCAGGCCGCGCCGACCCCCAACCAGCAGCCTGAAG TCTTGTACAACCAGATCTTTATAAACAATGAGTGGCATGATGCCGACAGCAAGAAAACCT

TCCCCACGGTCAATCCATCCACTGGGGATGTCATCTGTCACGTGGCTGAAGGGGACAAGG CAGACGGGACAGAGCAGGGAAGGCTGCCCGGGCCGCATTCCAGCTGGCTCGCCCTGCGCC GCATGGACGCGTGCGGGGGGGCCGGCTGTGAACCGCCTGGCTGTCTGATTGAGGAGACCG ACCTACTTGCAGGCTGGAGACCCTGAAAGACAGCCCTTATATCTCTACCGTGATCTGACAG GCTCAGTGCTGCGTCTTGCGCTGGCTGCAAACAGGAAACATCCATGACGGACACTCAGTC

CCGCAGACGGGAGGGGGCGAAATCAGGACTCCGCCGGCGCTGTAC

>'990809A-054.scf came from CONTIG 44 at offset 0;"C:\export\EGJDB\990809a\990809A- 054.scf(62>492) GCACGAGGCTCACTTTGGTTTTTTAAATGACGTTATTTCTGAGGCTTGACGTCCCACAAGC

TAATCTGTTTCTTCAAGGCCCTGGACCGGCAAGGGCAATCTAGGCTATGGGGAGTGTTAG CTTGTGTTGCTGACTTAAGACTTCAGCCCTTTCGCTGTCACCTGTACCAAGTGCCAGGCCA ACAGAGGGGGGGGGGAGGCAGCTTCACGACGGGGCTAGGGGAGTCTGGAAGGAAGAAG CTGCACGCGGGGAGGCTGGGCCTGGGGAAATGAGCATCTTGGACTCATAAGGCCTGTTCT TCTTTGTTCCTGGTCTGGTCCACAGGCACCAATTTTTCTTTTTTTTTGT^

TTGCTTCTGGAGCCCATGTTGTGGCTGAGGCAGACCGCGGAACCCACAAAGAGGGGTGGG CCCCTGCC

>'990809A-051.scf came from CONTIG 45 at offset 0;"C:\export\EG_DB\990809a\990809A- 051.scf(56>551)

CTCAGATCGCAGCGGAAGAGTCGTGCTTTTCTAACGTTTCTTAGCTTCCAAATCCCGACAT ACAGAGGCTGGTAAAAGCAGAGCAGATCTGGTCAGGTCCTGAGACCGCTGAGTCCAGAG CAATGTTGCTGAAGACAGTGCTCTTGCTGGCCTTGGCGTCCCAGGTGCTAGTCCTGGAGAA CGGGCTCCTGCGGAAGCCACCCATGGGCTGGCTGGCCTGGGGAACGCTTCCGCTGCAACA TCGACTGCAGTGAGGGACCCGAAGAACTGCATCAGTGAGCAGCTCTTATGGAGATGGCTG ACCGGCTGGCGCAGGATGGATGGGGGGACCTGGCTACGTATACCTTAACATCGTGACTGC TGATTGTGGGCGTGATGCCAAGGCACCCGGTGCGGGACGCAGCGCTTCCCACGCATGCCT TCTGCTGCTTGCTACTCCTGGCCGAGCTGGCTTTACAGACTGGNCACTCACTGCTGGGTAC CGGCCCCGCTGACA

>'990809A-034.scf came from CONTIG 46 at offset 0;"C:\export\EGJDB\990809a\990809A-

034.scf(60>595)

GCACGAGGCACTGGCTGGGAAGCACGGGGGATGACCTTCGTCGCACGAAGACGGAGATT TCTGAGATGAACCGGAACATCAACCGTTTTGCAGGGCTGAGATCGAGGGTGCTTAAAGGC

CAGAGGGCTTGCCTGGAGGCTGCCATCGCTGACGCTGAGCAGCGTGGGGAGATGGCTGTT AAGGATGCTCAAGCCAAGCTGGCCGGGCTGGAGGCCGCTCTGAGGAACGCCAAGCAGGA CATGGCGCGGCAGCTGCGCGAGTACCAAGAGCTCATGAATGTCAAGCTGGCCCTGGACGG TGGAGATTGCCACCTACAGGAAGCTGCTGGGGGGCGAGGAGAGCCGGCTGGGTCTGGAT GCAGAACATGTATATCCACACCAAGACACCGTGGCTTCGCAGTGCCTGACTTCGCCCACG

GACCCTGCTCACTACACCCGGCCCGCTCCTTACCCACCACTCCACCGGGGTGTGAAAGAG GGACCCGAGGGAGCGGGCCGGCCCTGTGTCCGCCAAGGAGGCCCGGCGCCTCCCCCCCC

>'990809A-052.scf came from CONTIG 47 at offset 0; "C:\export\EG_DB\990809a\990809A- 052.scf(62>521)

GGACGAGGGCCAACCGGGGTCGGAGAAGATCTCAAGATGGCTGGACGGGAACTTGCTCT AAAAACCATTGGACTGGGGTAGCTTTTGGGGGGGATCATCCCTCGGAACCAGAAGGCGGG CTAACTCCTTGAAGTCCTGGAATGAGACCCTAACCTCCAGGTTGGCTACTCTGCCTGAGAA GCCACCTGCCATCGACTGGGCTTTCTACAGGCCAACGTGGCAAAGGCTGCTTGGTGGATG ACTTGAGAAGAAGTTTATGCCTCGAGGTGTCTTACCAGAGATAAATTACTGCCAGGTGGT

GCTGAAGAAAGAAGATGTGAAAGTGTGTGGGTTTGTCTCATCAAAACAGATTATGATTGA TAGAGTGTGGAAAGAGGAATATTTCTTGTCAATGACTTGGGATGAGAAGATTCACACCAA TAACAAGAGACCCCTGCTCCAGCATGGACTTTGTGGTGCG >'990809A-050.scf came from CONTIG 48 at offset 0;"C:\export\EG_DB\990809a\990809A-

050.scf(60>423)

GCACGAGGGGGATATGTGCCCAGGTCCTGCCCTACCTGTCCCAAGAGCACCAGCAGCAGG TCTTGGGAGCCATTGAGAGGGGCTAAGCAGGTCACTGCTCCTGAGCTGAACTCCATCATC CGACAGCAGCTCCAAGCCCACCAGCTGTCTCAGCTGCAGGCTCTGGCCCTGCCCCTGACCC CCCTGCCTGTGGGGCTGCAGCCCCCTTCTCTGCCGGCGGTCAGCGCAGGTACCGGCCTCCT

CTCGCTGTCGGCGCTGGGCTCCCAGGCCCACCTCTCCATGAAGACAAAAACGGGCATGAT GGTGACACCCACCAGGAGGACGACGGCGAGAAGTCGATTATGGGCGGTGGTGGGGNGGG GGN >'990809A-015.scf came from CONTIG 49 at offset 0;"C:\export\EG_DB\990809a\990809A-

015.scf(61>564)

GCACGAGGCTCCGGTGTCCCCGCGCCAGAGACGCAGCAGCGCTCCCTCTGCCCACACCCA CCGCGCCCTCGCGCTCGCCTCTCCTTCCGGAGCCAGTCCGTGCTACCGCAGTCGCCCAGTC CACCACCACCCTCTGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGAT GTTCGGGGGCCCCGGGACCGCAAGTCGGCCGAGCTCCACCCGGAGCTACGTGACCACATC

CACCCGCACCTACAGCCTGGGCAGCGCGCTGCGCCCCACCACCAGCCGCACCCTCTACAC CTCGGGCCCGGGTGGGCGTGTACGCCACGCGCTCCTCGGCCGTGCGCCTGCGGAGCGGCG GGGCCGGCGTGCGGGTGCTGCAGACTCGGTGGACTTCTGNTGGCCGACGCCTCAACACCG GTTCAAGACACCGCACCACGAGAGTGGAGCTGCAGAGCCATGACGCTCGCCACTACATGA CAGGCGCTTCTGGACAGAAACA

>'990809A-096.scf came from CONTIG 50 at offset 0;"C:\export\EG_DB\990809a\990809A- 096.scf(60>437)

TGGTACGGGGATAGCGTCTGCGCTATGGCATATACGTCATCAACCAGCACGGGGAGGACA CCTTCAACCGGGCCAAGCTGCTCAACGTGGGTTTCCTAGAGGCACTCAAGGAGGACTCCA

CCTACAACTGCTTCATCTTCAGTGACGTGGACCTGGTCCCCATGGGATGACCGCAACCTGT ACCGCTGNGGTGGCCAGCCCCGCCACTTTGCCATTGCCATGGGCAAATTTGGCTTCCGGCT GCCCTATGCTGGCTACTTCGAGGGGTGTCGGGCCTGAATAATCCCAGNTCCTGGGAATCAT GGCTTGCCAACGAGTCTGNGGTGGGTGGTGAGATGATGACTCTTCACCGGTCTCCTGCTTG ATGAAGATCTGGGT

>'990809A-055.scf came from CONTIG 51 at offset 0;"C:\export\EG_DB\990809a\990809A- 055.scf(60>587)

GCACGAGGGTGTAATCTTGTGATATCACCTCTGTAAGCCTGGATCTCCCCAGGTGTCAAAG GAGGCAGTTGAATAAGAGGAACTATGAACTCTTCTATCTGTGTTATATAGACGGCCCATTT CAATCTAGAGCAGGGGAATGCCATCCCAAGAGGGCACTTTTACAGAGGAGGGGGGTTTGT CAACATCTTTGGTTGACATTACTCTGGTGTAGGGAGGGACGGAGAAGGCAATGGCACCCC ACTCCGGCACTCTTGCCTGGAAAATCCCATGGATGGAGGAGCCTGTAGGCTGCAGNCCAT

GGGGGCTCGAGAGTCAGACACGACTGAGCGACTCACTTTCATTTTCACTTCCTGCATTAAG AAGAAAGGCACCCACTCCAGGTCTGCCGGGAATCCCAGATGGGGAGCCGTGCTGTGCTTG GGGACACAAGCGACACACGAGGACTAGCGCGCGCAGGGGGAGCCGNGTTGATAGATGCT CAACCTCACGGGACCTGCGGTGTACATAGATATACTATATTTGCGA

>'990809A-064.scf came from CONTIG 52 at offset 0;"C:\export\EG_DB\990809a\990809A- 064.scf(59>611)

GCACGAGGAATTTATCAAAAATCCCAATAACTCAACACAGAATTTGCACCCTAACCAAAT ATTACAAACACCACTAGCTAACATAACACGCCCATACACAGACCACAGAATGAATTACCT ACGCAAGGGGTAATGTACATAACATTAATGTAATAAAGACATAATATGTATATAGTACAT

TAAATTATATGCCCCATGCATATAAGCAAGTACATGACCTCTATAGCAGTACATAATACAT ATAATTATTGACTGTACATAGTACATTATGTCAAATTCATTCTTGATAGTATATCTATTATA TATTCCTTACCATTAGATCACGAGCTTAATTACCATGCCGCGTGAAACCAGCAACCCGCTA GCAGGGATCCCTCTGTCGCTCGGGCCCTAAACα^GGGGGTCGCTTCTATGAATTNTCCAGG CTCTGTTCTTTCTCAGGCCATCTATTAAACGTCCTTCTTNCTCTAATAGAATCTGATGACTA

TGCTATAGCCAGCTACCATACGGCTGCNTCTTGTTTTTTATTTGTGAGCTGACTAGTTGCCG NAAN

>'990809A-094.scf came from CONTIG 53 at offset 0;"C:\export\EG_DB\990809a\990809A- 094.scf(54>456)

CGCACCGTCAGGCTGTACTGCAGGGCCGCGGGGGTGCCCAGTGCCACCATCACCTGGAGG AAGGAAGGGGGCAGCCTCCCCCCACAGGCCCGTGCAGAGCGCACAGACATTGCCACCCTG CTCATCCCCGCCATCACGGCCGCCGACGCCGGCTTTTACCTCTGTGTGGCCACCAGCCCTG CGGGCACCGCCCAGGCCCGGATTCAAGTGGTCGTCCTTCCAGGTGCCACCACCCCACCGG TCAGGATTGAGTCCTCCTCGCCTTTTGTGACCGAAGGACAGACCCTGNACCTCAACTGCGG

GGTGTCAGGGCTGGCCCACAGCCAGATCACGTGGTGCAGCGAGGGGGCAGCCTGCCTCCC ACGCCCAGTGCGCGGCTCCCGCTGCGGCGCCCCAGTATTAC

>'990809A-058.scf came from CONTIG 54 at offset 0;"C:\export\EG_DB\990809a\990809A- 058.scf(56>578)

CTTCGTCCCTCTGGGGTGGAAACCGGAAAATTCTCAGGATAGCGTGTACCTCCAGTACTGT AAAGTCTGCCAAGCATACAAGGCACCACGGCCACATCACTGCAGAAAGTGTAACAGATGT GTGATGAAGATGGACCATCACTGCCCTTGGATCAACAACTGCTGCGGCTATCAGAATCAT GCTTCCTTCACGCTGTTCCTCCTTTTAGCACCACTGGGCTGCATTCACGCTGCCTTTATTTT TGTTATGACCATGTATACGCAGCTTTATAATCGGCTCTCCTTTGGTGGAACACGGNCAAGA

TTGATATGAGTGCAGGCCGCAGAGACCCTCTCCGTTATTCTTTTGATTAGCTGCTTTGCGC CACCTGTTTGCCTGGGTTAGCTTAGAACACCTACGTCGGTGTGNTTTTATCAGAGAAATAT CTAAAACAACTCATGATATGATGAGAGAGTAGATGATTATATATATAATGATTTGTTTCTT GTTGGAGGATGAACTCACAGATAATGCGGTCGAGGN

>'990809A-059.scf came from CONTIG 55 at offset 0;*'C:\export\EGJDB\990809a\990809A- 059.scf(56>604)

CTTTCTGAAGAGCCAGGAATTCCTTCAGGCTCGCACCCCGACCTCAGCCAGCACCCCCATC CCACCCACCCCTCAGGCTCCCTGCCCTGCTGTAGATGCCGAGATCAGAGCCCAGGATGCC CCTGTGTCTCTGCCCCAAGCACGAGTTGGGAGGCAACAGGTGCCAGAAGTCATGTGGGCT

GAAGCCAAGGTGGCCATCCCCGCCAGCGTCCTGCCAGGACCAGAGGAGCCTGGGGGCCA GCAACAAGAGCCCAGACCAAGCCAGACCCCTGAAGATCATGCCTCCCTGCTCCAGCCCTC ACCCTGACCACTCCAGTCTAGAGACCAAAGATGGAGAACCCAGGCATCTAGAGAGACCA GCAGATCCCAGGAGGAGATGAAGCCACTGTGGGGCTGACAGAAAGAAACAAGGTAGAGC CAAGCAGGAGCAGCTGCAGAGAAACGGCAGAGAGCGTCTGGACGGAAAATTCAGATGCC AGCCTTGAAAAGAGCTTGACCTTGGATAAAATCAAGCATGNTCCTGGAACAACCTGAACT TAACCTAAAGGG >'990809A-084.scf came from CONTIG 56 at offset 0;"C:\export\EG_DB\990809a\990809A-

084.scf(56>504)

CTTCGGCACGAGGCCCCCTTCCTAGGTCGGGGGGGACTTTTGTCTACCCTTCCCTCACCCT CGAGGACCCTAGTGGCCTCTGATGCCAGGGGTGCAGTGCCTGCCCAGTGAAGGAAAGTAG AAGAAAGAGGCAAGGCCCGCTCCCGGCTCAATGTTTGACCTTCCCAGGCCCCATTCCCCC CTTTATGTAACTGTCTTCTTATATAAATGGTGATCTTTΓTCTCTTCATCCACCATTGATGTTG

GGTCAAGAAACTGGGCTGGATGGGATGAGCACCCATGGTCCGTCCTGTGCATCTTTTCCTT GCTTATTACGTGGTTTGGGCTGTCAGCCAGATTATATTCCCCAACCCATTTTTGCCTTCCTC CTTCCCGGGTGCCTTGGTGTTTGGTTTATTCCGGGGTCCAGTTCCTATTTTTGGGGGTTCTT GGTGGGGGTCTTTCTTCTCA

>'990809A-063.scf came from CONTIG 57 at offset 0;"C:\export\EG_DB\990809a\990809A- 063.scf(62>547)

GCACGAGGGTGGGTTAAGCATGAATCCTTTTACACAGTCATTAATATTGTCTTTTAGGGTT TATGTAGTATTCTATAGTTTTTGTGGAATGAACATAAGAAAAATAAGTAGTACTTCATAGA TCCTGCTGCATGCCAGACCCTATTCCAAGTATTTΓACATATATTGATTTATTTAATTATCAG

AATGATCTTATGTAGGAACTACTGCTTCTATATCAATCCAGCAGTCCCTGATTTCCACACT GTAGATGAGGGAGGATAGCTCACAGGCAGCAAATGAAGCAACAATGTGCTTCACAGCAN ACTGTTAGCAGATTCTTAAGGCAAAAAAAATGGCGATGGTTGTCTCATTATCAGGAACCT AAGCACGCTGATGTCCCCGCGTCCCCTCTCTCCACTGGGGAGACGCCACACCCTTCTTATG TTTCCCTTGAGCATAACATCTACCTTAACACCCCCCCGCATTATCAGCAAAAGAAACACAA

>'990809A-060.scf came from CONTIG 58 at offset 0;"C:\export\EG_DB\990809a\990809A- ^' 060.scf(58>515) GGGCACGATGCTCACTTTGATTTTTTATATGACGTTCTTTCTGATGTTTAACACCCCACAAA ATATTTTCATGATTTACGTCCCTGTGCACCCAAGGGCCGTCGATGCTATGAAGAGCGATGG GTTGCTGGGGGGCCTTAAAACTGAAAAGCTTTCGGTTGCCCCTGTGCCAATCACCAGGAC

AAAAGAGGTGGGGGGGAAGCAGCTAGACAACTACGTCTAGGGGAGCGAGCTGGAACAAG GGCACACACGGACGCCGCGCCTGCCTGAATGAGGGACAGGGACTCCGACGACCTGTGTTC TTGTGATTCTGGACGTGACACAGGCACTCTGCCCTGCGCCTTTCTGTACGCTCTCTTGCTTC GCTGCGGGCGGCCCTTGAGGCGGACTGAGGATGAGCGCGCAACGCCACACGAGGCCGCG GGCCCCTGCCCAGCGCGGCGCGAGAGGAAGTGCCC

>'990809A-091.scf came from CONTIG 59 at offset 0;"C:\export\EG_DB\990809a\990809A-

091.scf(56>557)

CGGACTGGGAGGTGAACCTCACCGACTCCTTCTGGAACTGGGAGAAGGGCTTGGTTCTTG AAACTCCTCAGGTCGGACTTTTTTTTTTTTTTTAAACTGGGGGCTATGCTGCCCT^^

AGGTTTTTCAATCGTTGGTGTTTGCGTTTCCAACTTAAGAGAATTCCAGGCACTCCCCTTCC CCCTCCAGTGACATACTTGGGCAAGCGGTCATCGTTGCGTCATGGGGCAGACGGGGGGAG CTTCCTGCTGCCGNGCGGGGGTGGGGGCCGGGAGGAGGACCTGGGTGTGGGCCGCCCTGG GGAATGGAGGNGGGCGGCCTGAGCACTGCGCCTGCTGCGGTTATTGCCCGAGCCCCTCGC CTCGGGGTAGAGGNCCGACTATTTCTTTAAAATTTTTTCTGTGGGCGTTGAGTGGGATGTC

ACGTCCAGCTGCCTCAACCCACAACACACCGACGTCTGCCGATACAAATGAGGAGCAGAG CGACTGATCGGCTGCGA

>'990809A-088.scf came from CONTIG 60 at offset 0;"C:\export\EG_DB\990809a\990809A- 088.scf(56>586)

CTTGATTTGAGTCTGTTTCTAATCCCTGTGTCCTTTGCTCTCCAGGGCATGTGTTCCTTTCAT ATTTGTTGGCACCCGAGAAAACATCAGCAATGCTCAGGCTCTGCTGGAATATCACCTCTCC TACCTGCAGGAGGTGGAGCAGCTCCGCTTGGAGAGGCTGCAGATTGATGAGCAGCTTCGG CAGATTGGGCTGGGCTTTCGGCCTCCTGGAAGGGGGCGGGGCAGCGGCAGCAGGGACAA GGCTGGATATACCACTGATGAGAGCTCCTCCTCTTCCCTTCATACCACACGAACCTATGGG

GGCAGGTATGGGGGCCGGGCCGGGGCCGGAGGACAGGCGGTCCTGCCTATGCTGTGAGA CGNATCAGAGAAGAGGGAGAGCCCCCCCGGCTGGCCCGGCGACGGGATCCCCGCCCGGG GAGAAAGCCGAGCGNCTATAGAGGCGGGTAGGGACCCCACTGCCCCGNCCACTAGATCA CTCTTATGATATGTAGCTGAGACAACGAATCTTCAACACGGCACATCACA >'990809A-078.scf came from CONTIG 61 at offset 0;"C:\export\EG_DB\990809a\990809A- 078.scf(55>588)

GTTTTTTTTTTTTTTTTTTGATGGAATGTA GTAAAGCTTTGGCACATACAGTATAAAAAATAATCACCAACCATAATTAGACCAGATTCC

TCTTATCAACTGCATACTAAGTATCTTCAGTACAATTTTTTTTCCATATAAAAATACTGGGA AAAATTGATAAATAACAGGTAAGAAAAAGATATTTCTAGGCAATTACTAGAATCATTGGG AAAAGTGAGTACTGGGGCTGTTCTGAATACCACAGTACAAAGGACATGCTGTTCCTACAA TATTGCGGGCCAGTCAGTTAAGTGGAAGCAGAAGTGTTCAGGTAACTTTCCTACTTAAAAT TTGGTAATATCATTTCAAGACATTTTGTATCTTGGTTGGGTGCATGTGCTCCCTAGGATCCC

ATCCAAATCACAGTAGATCACTCATTTAAATCTGATGCATGGATATTTGAGAATGATACCT CTGCTCATGATGAGAAAGCTGAACACTCAGGGAGCTGGAGAGCGT

>'990809A-032.scf came from CONTIG 62 at offset 0;"C:\export\EG_DB\990809a\990809A- 032.scf(53>590)

TGGTTTTCTTAGGCACGGGGGGAGCTGAGTAGGTGTGGGGATGGGACAGGGAAGGGCAA AGGACAGAGCGGGGGGACCTTTGCCTCTCCAGGTGCCCCACGGCCAGCCCCCCGCGTCCT TCCTGCACTGCTCCCACACCCCACACCCCCAGGGCCCTGAGGGAAAGACAGGCCCCGAGG CCCCAGGCTGGAGAGAATAGCCCGAGGCATGATGCCGCACTCCTGGCCCCGAGACTTCCC CTTCATCCCCTCCCACTCCCCACAGACCCCTTTTGACTCTCATCCTGAAGCCTAGAAAGAG

AGAGAAGCGGGGNGGGGTGGGTCTGTGGGGNGACGGGCGGAGGAGGCGGGGAGCAGGG AAAGGCGGGAGCCCTCTGTGCTGGTTTTTACCAGATACACAGCAGCTTCCAATATATTATT CACCCCTGAAAAAAAAAAAAAATGAGGGGGCCGGGACCATCGNCTATGGAGNGATACAT CATGNCGCGTTTACAGGGATGGAAACTGCGTACACTATGCTGACCATCCCTTGCGGGGGT

>'990809A-090.scf came from CONTIG 63 at offset 0;"C:\export\EG_DB\990809a\990809A- 090.scf(60>584)

GCACGAGGCTCGGGAGGTCAGAAAGCCGGGCCGCGGGCGGCACCGAGAACTGGAGCTGG GATCGGGGACGCACAGAGGTCAGGGGAAGTAATCCTGGACCATGACTCAGCAGCCACTTC GAGGTGTGACCAGTCTGCGTTTCAACCAAGACCAGAGCTGCTTTTGCTGTGCTATGGAGAC

AGGTGTGCGCATCTACAACGTGGAGCCATTGATGGAGAAGGGGCATCTGGACCATGAGCA GGGGGGCAGCATGGGCCTGGTGGAAATGCTGCACCGCTCCAACCTGCTGGCCCTGTGGGC GGGGGTAGCAGCCCCAAGTTCTCAGAGATCTCAGGGCTGTCTGGGACGATGCCCGGGGGG GCAGGACTCCAAGACAGCTGTGCTGGAGTTCACTTCACAAGCCGGCGGCTGGCGCTGCGC, ATGACAATCGGATCGGCTGAGAACGCTTATGGTTCTCTCCTGACATCCGAAGCTGTGATTG

CACCGGACACCCAGGGCTTGGACTTGTCCACTGAAACAGTGTGG

>'990809A-087.scf came from CONTIG 64 at offset 0;"C:\export\EG_DB\990809a\990809A- 087.scf(61>433) GCACGAGGCGAACGAGCAGTACCGGGCGCTGCGCCCCGACCTGGCGGTAGGGGGAGGGT

GGATAGGAGGGGTGCGGCGGCGGGGGGGAGCGGGGGAACCCGGACCCCACAGGACATCC GAGGACGGGGGGCCTCTCCCCTGGGTCAGTACTGTCTTTGCTCCATGTCCAGACATCTTCC TGTTTAAAATGAACAAAGCTCTCACTTCAAAATCCACACTTCATTTGGGACTAGACAGTCG GGGGTTGGGGTTGTTTCCTTACTGCTAAACAAAATCCTCCACCCGGGACTCTGATTTGGGG ACCAAAAGCCCCCCAGAACCTCACCTGTGAGCCTCGCTGTGTGGTGCGGGGAGGGTGGGT

TGGGGGNNNGGG

>'990809A-067.scf came from CONTIG 65 at offset 0;"C:\export\EG_DB\990809a\990809A- 067.scf(59>555) GCACGAGGCTGCAGATTCCTTCCTATAACTATTTATAGGTAGTCCTGACTCCACTACCCGC

TTCCCAAATGGGCTGTTCACGCGGAAGAGGCTCACGTTTCACACAGCAGAACCCGAGAGA ATGGTGTGAACTGTCGGGGGGGAGTGCATGCAGGAGGCAGACTGAGTGCCCTGCTGTGCT CACCTGTGCTTATCACTCTTCTAGCATCGCGTCCACGCTGGTCTCCCTCGGGAACCAGCTG TGTCAGAGGCCCCTCTGTGGCTGGATGTCTAGCTTGCTCCGCCAGGCACAGCGGNGCTTTG GGGGCCGCAGGGGGCGGCGCTGTGCTGGGCTCACCCCGCGCGGNNACACGCTCCCTCTTG

GCCNCACGGGTGTCCGGTCTCCCTCTCTGGCTTCGCTGTCCCCATGTTAGTCACANGAGAG CCTGGCTCCCCTGCCCTTATTTGNATGAAATGGCTAGATCTGCCTTACTCTTACTGATGATG AATTGATATGC >'990809A-068.scf came from CONTIG 66 at offset 0;"C:\export\EG_DB\990809a\990809A- 068.scf(56>612)

GTTGAGTCTAGGAACCGTCCCAGCATGGCTCCCCTCCACCGCCACCACCACCACCATGTCC CACCCCCTGCGATGGCAGGTGATCTAGCTCAGGGGGGCCTCCCAGGCTGAGCAGGAAAGG AAGTTTCCAGAAAACCTGGGCTGGGGGAGGAGTCCTGGGGACAGCAGATGCCTGCCGCA

GAGGGCTGGCTGCCTGTGGACCCTTCCCAGCTCAGTGGAGGCCACGTTAGGGGCCCTCAA GCAACCCAGAAGCACAAATTGGTGGTTTGGGGCCACGCCCAGCTGGGCTGGCATCCACGA ACCTGGAGAGTTGGCTATGGCAGCACCAGGGCCTCGGCCCCACTCCCCTCCCAGGGTCCC CGTCCTTTCCCCCGCCAGGCTCTGCTCAGGCCAGCCCCTGAGCCGNCAGCGGGCCCCTCTA CCGGGGCCTGGTCTTGAGCACACCCTGTCCACTCACCCACTCTNNTTCCTCGCCACCCTTC

CCCGCACCATCGCCCTATATCGGGTTGCTCTCAGGCCCACTGAGTCACTTTCTANNTTGTC TGGCCTGCGCGCGT

>'990809A-069.scf came from CONTIG 67 at offset 0;"C:\export\EG_DB\990809a\990809A- 069.scf(60>613)

GCACGAGGGGAAGCCCATGTTTTATGTGTGCACACACACACAAATGTACACACACTCATG GTCTGCCAGTCTAGCAGTGGGAAAATGAAGATGAGGCAGGGTCTGAATGTCCACTTGCTC TCACTGACTGCCACGGAGCATGGTATGTGAAGTGGGGTCTTATCTGGAGAACTGTCCATC AGGGCTGTAGTCCTGGCTACAGTCCACCAGGGCTGTAACATGCATTATCCATTTACAGTCA GCGAAACCATCGATAGAAAAGCCACAACAACAAGGGAGCTGCAGGAAAAGAATCATGTA

AGCCCTCCTGGGTCCTTCATGGCTTTAGGAAATAGGGAAAGGCACCTAAAATGAGCAGGA AGGGCAACTAGAGTGGGGTTGGAGGTGGGGCAACCACATTTCAAGGGCTGCCAGTCTCAA CGAAGCTGCCCAAAGCGACACCTATGGTGTGGTGTGTGCCCGAAGGGCCAGCAAGAGGA GTCTACATTTAAAGCTTACGTGACTCTTGTGCCATGCTAAACCACCTCAAGCAGGGGGGCC AACCCGGCGCGCCN

>'990809A-075.scf came from CONTIG 68 at offset 0;"C:\export\EG_DB\990809a\990809A-

075.scf(60>563)

GCACGAGGGTGAAATTCAGAAGAAGGCGAGAGGGCAAAACTGACTACTATGCTCGGAAA CGATTGGTAATCCAAGATAAAAATAAGTACAACACACCTAAATACAGAATGATTGTTCGT

GTAACGAACAGAGATATCATTTGTCAGATTGCTTATGCCCGTATAGAAGGAGATATGATA GTTTGTGCAGCTTATGCTCACGAACTCCCAAAATATGGTGTGAAGGTTGGCCTGACAAATT ATGCTGCGGCATATTGTGCTGGCCTGCTGCTGGCCCGCAGGCTTCTTAATAGGTTTGGTAT GGACAAAATTTATGAAGGGCAGTCGAGGTGACTGGAGATGAATACATGGGGAAGCTCGA TGTCACCTGTGCCTCACCTGTACCGGTGCGGACTGCCGCACACTACGGGATAAGTTTTGGG

CCTAAGGAGCGCGNGGAGCTGCTTCCTCCAGACCACGGTCTGNTTGATTAGAGCAAGATC AGGCTGGACACGAGCCAATGCCA

>'990809A-074.scf came from CONTIG 69 at offset 0;"C:\export\EG_DB\990809a\990809A- 074.scf(62>380)

GCACGAGGAAACAGGTTAGTTTTACCCTACTGATGATGTGTTGTTGCCATGGTAATCCTGC TCAGTACGAGAGGAACCGCAGTTCAGACATTTGGTGTATGTGCTTGGCTGAGGAGCCAAT GGGGCGAAGCTACCATCTGTGGGATTATGACTGAACGCCTCTAAGTCAGAATCCCGCCCA GGCGGAACGATACGGCAGCGCCGCGGGAGCCTCGGTTGGCCTCGGATAGCCGGCCCCCCG CCGCCCCCGCCGGCGGGCCGTCGCCCGCGTCCCCCGGGGCGCGGCGCGGCGCGCCCCCGC

TGCGCGTCGGGACCGGGG

>'990809A-086.scf came from CONTIG 70 at offset 0;"C:\export\EG_DB\990809a\990809A- . 086.scf(62>593) GCACGAGGCTAAGACCCGTGTGCAGCAGCGGCGGGCGGGGGTAGAGGCGGGGGCGGGGG

CGGCGGCAGCGGCAGCGGCAGCGGGGCTCGGGAGGCAGCGGTTGGGCTCGCGGCGAGCG GACGGGGTCGAGTCAGTGCGTTCGCGCGAGTTGGAATCGTAGCCTCTTAAAATGGCAGAT GATTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCGATGCAGTGCTCA GCATTACGTAAGAATGGCTTCGTGGTGCTCAAAGGCCGGCCATGTAAGAATGTGGAGATG TCAACTTCTAAGACCGGCAGCACGGGCATGCCAAGTCCATCTGGTTGTATTGACATTTCAT

GGAAGAAATACCAGATTCTGCCATCACTCATATAGGAGTCCCCACATAAAGAACGATTCA CTGTTGCATCAGATGATACTTCACTCCCAAGAAGGGAGTGCGGAGACTCCGCGCCGAGAG ACCTGCAGAAAGACAAAACACGGGAGAAAATTGTCAGGCGCCCCTGACAGGCG >'990809A-072.scf came from CONTIG 71 at offset 0;"C:\export\EG_DB\990809a\990809A- 072.scf(293>632)

CAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGCTAAATCAGCTCATT TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGTGAT AGGGTTGAGTGTTGTTCCAGTTTGCAACAAGAGTCCACTATTAAAGAACGTGGACTCCAA

CGTCAAAGGCGAAAAACCGCTTCAGGCGATGCCCCATACGGAACCATACCCTATAAGTTT TTGTGTCGAGTGCCGTAGCACTAATCGAACCTAAGAAGCCCGTTTAAGCTTACGGGAAGC GGGAAGTGGAGTAAGAGGAAAAGGAAGGGGGGCCCTGC >'990809A-073.scf came from CONTIG 72 at offset 0;"C:\export\EG_DB\990809a\990809A-

073.scf(60>570)

GCACGAGGAGAAGGGGGACGTGGTGCTGCAGAGTGACCACGTGATCGAGACCCTGACCA AGACAGCCCTCAGCGCTGACCGAGTGAACAACATCAACATCAACCAGGGCAGCATCACGT TCGCAGGGGGGCCCGGCAGGGATGGCATCATTGACTTCACACCCGGCTCGGAGCTGCTCA TCACCAAGGCCAAGAACGGGCACCTGGCTGTGGTGGCCCCGCGGCTGAACTCGCGGGGAT

GAAGGCGCCCAGCGGACCCCTCCCGCCTCCCAGTGCTTCGCTCATCCCCTCCTNCCTTCCC AGCTACCAAAGACTCGAGCTTGCAGACAGGGACCCAGGGACACCTCNGAGCCCACCGAC AAACTCCCGCCTNCTGCTCGGCCCTCTCTGNGGGGGCGGGAGGGGCGCAGGAGCTGCCCA GNAGTGGGCAGCCGGGCCACACATAGGAGAGCCGGGCAGAGCAGCGCGCAGCCCCTGNC ATGCAATATTGAGAGAGGACTTTGTGAGTTTTN

>'990809A-016.scf came from CONTIG 73 at offset 0;"C:\export\EG_DB\990809a\990809A-

016.scf(51>603)

TATGGAATGATGCTGGCAGGCCTAAGGTTCAAGTAGAATACAAGGGAGAGACAAAGAGT TTTTACCCAGAGGAGGTGTCATCCATGGTCCTGACAAAGATGAAGGAAATCGCAGAAGCC

TACCTTGGGAAGACGGTTACCAACGCTGTCGTCACAGTACCTGCCTATTTTAATGACTCTC AGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAACGTACTTCGAATCATCA ATGAGCCAACTGCTGCTGCTATTGCCTATGGCTTAGACAAAAAGGGTGGAGCAGAAAGGA ACGTGCTGATCTTTGTTTTAGGGGTGGCACTTTTGATGTGTTAATCCTCACTATTGGGATGG ATCTTTGAGTCAATCTACACTGGAGTACTCCTTGGGTGGGAGACTTGACACCGCTGTTTAC

CATTTTTGCGAGTCAGCGGACACAGAAGATTAGGAAACAGAGGTGGCGCGCTCGTCGGTG GGGGGCTAGCGCCTTTTTCGCCCCAGCAGTTGGATGTTCCTTTGAGGATGCTTTACTTTTCC GGCCCTTC >'990809A-014.scf came from CONTIG 74 at offset 0;"C:\export\EG_DB\990809a\990809A-

014.scf(61>603)

GCACGAGGCAACGTCATCCGCTATTTCCCCACGCAAGCGCTCAACTTCGCTTTCAAAGACA AGTACAAGCAGATCTTCCTGGGGGGCGTGGACAAGCGCACGCAGGTCTGGAGGTACTTTG CGGGCAACCTGGCCTCCGGCGGGGCGGCCGGGGCCACTTCCCTGTGCTTCGTCTACCCGCT GGATTTCGCCCGAACCCGCCTGGGGGCCGACGTGGGCAAGTCGGGCAGTGAGCGCGAGTT

CAGGGCCTGGGAGATTGTCTGGTGAAGATCACCAAGTCCGACGGCATCCGCGGGCTGTAC CAGGCTTCAAGGGNNGGTGCAGGGCATCATCATCTACCGCGCGNCTACTTCGCATCTACG AACCGNCAGGGCTGCTCCCGACCCCAGACACGCCATGNGGTGAGCTGAAGATCGGCAGA CGGACGGCGGGGGGCGTGGCTCTACCCTCGCACGGCGGGGGCTGAGAGCAGCGGCGCAA GGACGCACATGACAGCCCGGGCTGTGCGAGACTAGACAGGCGAGGCTTTCAGGCCTGGCA

GCN

>'990809A-018.scf came from CONTIG 75 at offset 0;"C:\export\EG_DB\990809a\990809A- 018.scf(57>603) AAAGCGCTCAAATTTATGACATACAACAGCTGTGGCCAGACTCTGCTTAAATCAAGAGAC

AATATGTCTAGCAAGCACTGCTATGGAAAACTGGAAAATTGTGTGGGCCAAAACAAAACT TGCCAATGGGACTTCCAGTATGATTGTGCCCAAGCAACGGAAACTCTCAGCAAGGCTATG AGAAGGGAAAGGGACTGTGTGTCAAATATTTTGAGCAGAGGGCAGAATCCGATCAAGGG GAATTTGTGGAACATCTTATTTCCAAATGTGTCATTATCCAACATGGGCACATAAACTCAT ATCTAAACCTTGTTGTTGAGGGGATTTCTTACTNTCTGCCGCTGGNGTGTAGTCACATTGT

GGGACACCTGTGTACTGGGTGCGGATCATTTGTGTGCGNGACGGGTGGANAGAGGGACGC GNGCGGCGGTGGTGTTTGGGAGAGAGATGAAGAAGGGAGGCGATGTTGGGGAGGCGGGG ACGAGG(-^GGGCGGTTTGTAAAACAACCCGNGGAAGGCCCCACCTTTTTGTGGCTTCTAT TTTCGCC >'990809A-019.scf came from CONTIG 76 at offset 0;"C:\export\EG_DB\990809a\990809A- 019.scf(54>593)

CGGCAGCATGTCTCACAGGAAGTTCTCTGCTCCCAGGCATGGGTTCCCTGGGGCTTCCTGG CTCGGAAGCGCAGCAGCCGGCACCGCGGGGAAGGTGGAAGAGCTTCCCCAAGGATGACT

CTTCCAAGCCTGTGCACCTCACTGGCTTTCTTGGCTACAAGGCTGGCATGACCCACATTGG GGAGGGAGGTCGATAGGCCAGGGGCCAAGGTGAACAAGAAGGAAGGGGGGGGAGGCTG TGACCATCGGGGAGACTCCGGCCCATGGTGATTGTGGGCATCGTGGGCTACGTGGAAACA CCCCGGGCCTCCGGACCTTTAAGACCATCTTTGTGAGCATATTAGCGACGAGGGCAAAGG CGCTTTACAAGACTGCATAAGACAGAAGAAGGCCTCACAAAACTGAGGAAGGCAGACGC

GACGCAGAAGAGTTGGAGGATTACAGATAAAAGACTGCAGTATCGGCATGCCAACCAAT CGCTGTCTTGGCAGAGAGCCCTATGAGTCAGGACGAGCCGNGCCAAATGACGGCGGGAGT GGC >'990809A-083.scf came from CONTIG 77 at offset 0;"C:\export\EG_DB\990809a\990809A-

083.scf(55>579)

GTTGACCTTGACCTGGGTAACTATGAACGTTTCCTTGATATCCGCCTCACCAAGGACAATA ATCTGACCACTGGCAAGATCTATCAGTACGTCATTAACAAGGAACGCAAAGGAGATTATT TGGGGAAAACCGTCCAAGTGGTCCCGCACATCACAGATGCAATCCAGGAGTGGGTAATGA GACAGGCCTTAATACCCGTGGACGAAGATGGTCTGGAACCTCAAGTGTGTGTTATCGAGC

TTGGTGGGACAGTAGGAGATATAGAAAGCATGCCCTTTATTGAGGCCTTCCGTCAATTCCA GTTCAGGGTCAAAAGAGAGGAACTCTGTTATATTCATGTCAGCCTCGTGCCGCAGCCAAG TTCACAGGGGACAGAGACTAACCCACCAGACAGGGTCGGGACTCAGAGGCTTGGCTTCCC AGTCTGTTGTTGCCGGGCTCAATCTCTGACCGCAGGAAAGAAAATATGAGTCTGCTGGAA CCGACAGGACTGGCCTGAGCTCGCCTTACGGTCCCTATGTAGA

>'990809A-081.scf came from CONTIG 78 at offset 0;"C:\export\EG_DB\990809a\990809A-

081.scf(61>602)

GCACGAGGGATTTTTATTTTTCAGCCTGTTTGTTTTCAAGGTGGAGAATAAAAAACTGACT CTGTTCCAATCTTATTGGTACCAATCAGTATACATCACTTAAAGCTGTTGCTCCTGAGCTTA

TATTGAAGTAGCCCTAAGTACCTGGTGAAGTTTACATGTATAAGAGAGTTACACATTTGGG GGTTCAGTTGATTTCAACGTAGTAACATAAACATACTCTAGAACTATACACAAAGATTTAC AATTTAAAAACATAATCAGNCACCTTATTACCTGGAAATTTATTACTTTTTACTACTCTTCA TTTGCTTCAGACAATACATATTTCATTCCTTATAATCTAGAATTCAAGAACCAGGACTCTA ATCTTTTTCCTCTCATCTCTTATCTTTCTAAAATTGCCTGGGTAGAGATCAGGTATAAATAT

• TTATATTAATTGATTATTATGGTAGGGGGAGGCAAGAACCAACCATACAGGATCATGCTA CGATTTAGACATAGNCAAAACAGAGAAGGANNATATTTTTAAGGATATATAT

>'990809A-077.scf came from CONTIG 79 at offset 0;"C:\export\EG_DB\990809a\990809A- 077.scf(55>571)

GTGGTACTAACCTTACTTCCCTTAGTGTTGACCCGGAGAAGGAACGATGGTGCTGGATCTG GATTTGTTTCGGGTGGATAAAGGGGGGGAACCCAGCACTCATCCGAGAGTCGCAGGAGAA GCGCTTCAAGGACCCGGGACTGGTGGACCAGCTGGTGAAGGCAGACAGCGAGTGGCGAC GATGCAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATTG GAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAAATGATGAGTCCATTCCAGAAGAGTAT

TAAATCTCGATGACCTCACTGCAGACACTCTAACTAACCTGAAAGTCTCACAGATCAAAA AGTCCGCCTCCTCGNCGACGAAGCCTCTGCAGGTGACGCCGAGCGGATAAAACGGGAGCT GACGCCTGAGAGCGTTCGGAGATCGGGACCTCTGCACCGNCGNGCCATCACGAGACAGAT GCGACACAAGANAGAGATTGGGGGATGTCAGNCAGAGA

>'990809A-085.scf came from CONTIG 80 at offset 0;"C:\export\EG_DB\990809a\990809A-

085.scf(27>51)

TATCTAGTGGTTTCCCCCCGCTTCT >'990809A-082.scf came from CONTIG 81 at offset 0;"C:\export\EG_DB\990809a\990809A-

082.scf(61>456)

GCACGAGGCTCTGGCGTCCCGAATTCCGTCTGTTTTTTCTCACAGGCTGTGTCCCGTCCGCT GGCCCAACACCTCAGGGGAACGATGGGCCGCAGAGTCCACAGCCACTGCCGGCATCACCG CGGAGCTGGGTTCTGCCGACAAAATTGAAGAAGATGCCCCTGCTCCTTCTACTTCTGCAGA TAAAGTGGAGAGTCTGGATGGGGATAGTGAAGCTAAGAAACTCTTGGGATTAGGACAGA AACATCTGGGAATGGGTGATATTCCTGCAGCTGGCAATGCCTTCCAGGAAGCAGCTAGNC TTTTAGGTAAGAAGGAGGGAGAGACAGCTAATGAATGTGGAGAAAGCCTCTTTTTTTATG GGAATCGCTTTGGAGTGGGCAGATGGGAGATGGG

>'990809A-071.scf came from CONTIG 82 at offset 0;"C:\export\EG_DB\990809a\990809A- 071.scf(49>598)

TAGGCGCAGATCACCCTCGGCCTGGTCAAGTTCAAGAACCACAGGCCATCCAGACCGTGC GCGCCCGGCAGAGCCTGGGGCCGGGGCGCTGTGTGCTAGAGCGCGGGGGCGCGCCTGGC CTGCCCGAGGTCGTGCCAGCTTCTGGGCCCCCATCGGCTCTCGGAGCGTGACTGTGCTCCT

GACTGTGCTCCGAGTGGCGAGGCTGCGGCTGCGGACACCCCCGTGGAGGAGGCGTTGGAG TCACGGGTCAGCGGGAGCCAGCAAGGAGGGGGACAGCCACGGAGAGCTGAGGATGAGGA TTCGGCCCCGGGCGCTCAGGCTCTCAGGACGTGCCTGTCCCAGCCCAGCCTCTGAGCTCCA GCAAGCCCCGACCGCTGCGCCCTATTGCTACTCTGCAGATGTCCGACCAGCTTGGGCTGGG CTGCAGAGGCGGACCCGGATCGTGACCACATTTAGACTGGAGCCGCTGGGACACGGACAA

CCCCAGCTAATTGATCACGAGCCATCTGGGTGTGGGCTGGTCCTCCGACCCCCCTCGCCCT TTTACATC

>'990809A-070.scf came from CONTIG 83 at offset 0;"C:\export\EG_DB\990809a\990809A- 070.scf(59>543)

GCACGAGGGTTTCACATAAAACACAGGGAAAAATGTCACGCTTGAAGGTGGCCCTTCAGT TCTCCTAGTGAAAGGGCATGTAGCAACAGTACCTTGTGCCTGGCCATCTTTACTCCAGCTC ACGTGCTCTGGTACCTCATTGTGTCCTCACAGCAGCCCTGGAAGGCGGGAGGGGCGCTAC TGCCATCCTTGTGTGTGTGAAAACTTGAGACCGAGATAAGGCCAGCGACTTGCCTGACTA AAGTTGCCTAGGTTGCCCAAGCTGTGCCATCATTCCACACTCAGCAGAGACGGGGAGAGC

ACCTGTGGGGCAGAGACTGAAAAAAGTCCCCAGNTCCGCTTTGTCCTCCTGGGCCCGCGG CTGCCCTGCCCAGCCAGGTACTCTTTTCTCTTCACGATGATAAACCTGACACCAGTCTTGT GCGACACAGGGGCCTGGCTATCTCTGCATATCACAACATACTGGCTCCTGGGGCACGGNA AGA

>'990809A-080.scf came from CONTIG 84 at offset 0;"C:\export\EG_DB\990809a\990809A- 080.scf(61>603)

GCACGAGGCTTGCATCCAGTTTGACTACAAAGGAGCTTCATCTTTCAAGATAACCCGTGG AATTGAAGCAGTTGGTGGTAAATTAAGCGTGACGTCAACAAGGGAAAACATGGCCTATAC TGTGGAATGCCTGCGGGATGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACA

GCACCAGAATTTCGACGCTGGGAGGTAGCTGCCCTTCAGCCTCAGCTAAGGATTGACAAA GCTGTGGCTCTTCAGAATCCACAGGCTCACGTCATTGAAAATTTGCATGCTGCCGCTTACA GAAATGCCTTGGCTAATTCCTTATATTGTCCTGATTATAGGATTGGAAAAGGACACCAGTG AGTTACTGACTATGTACAGAATCATTTACAGTGCAGGAGGCTTTGTTGACTGGGGNGTCAT CTGCCTAAGCAGTGCTGACACTTCTACATAAGGGGGCTTGTTATTGGGCAAGCCAGACCA

TGAGGAAATGAGACAGAGAGACGCCGCCATCCGTTTGGCAAAGCACCTGAAGCAAACAA

>'990809A-076.scf came from CONTIG 85 at offset 0;"C:\export\EG_DB\990809a\990809A- 076.scf(56>562) TTTGATTGGGAGGAAAAAGACAGGCCAAGAAGCTCTCTCTCAAACAACCATCTCATGGAC

CCCATTCCAGGAAAGCTCTGAGTATATCATTTCATGTCATCCAGTTGGCATTGATGAAGAA CCCTTACAGTTCCGAGTTCCTGGAACCTCTGCTAGTGCCACCTTGACGGGCCTCACCAGAG GGGCCACCTACAACATCATTAGGGAGGCAGCAAAAGACCAGCAGAGGCAGAAGGTTCGC GGGAGGGGGGGTACCGNGGGCATTCTGTTGACCAGGGCCCGAGCCAGCCCACACATGACT CCTGCTTCGACCCCTCACGGCTCCCATATGCCATTGGAGAGGGTGGGAGGGATGGCTGTTT

GGCTTTACTCTCGGCGCGCTTAGCTTGGCGTGGGCATTCCATGCGATATCTATGTGCCTGA CAGGGAGAACTCAGAAGAGGAAGGGACGGAGGGAGATGGCGAGAGGCGCCGGCCTGAA TGAAAGAGATAGGTGACCAGAGCCAG >'990809A-005.scf came from CONTIG 86 at offset 0;"C:\export\EG_DB\990809a\990809A-

005.scf(5>15) ATTTTCGCGGN >'990809A-011.scf came from CONTIG 87 at offset 0; "C:\export\EG DB\990809a\990809A-

011.scf(49>63)

TTTTGTTTAACACCT >'990809A-023.scf came from CONTIG 88 at offset 0;"C:\export\EG_DB\990809a 990809A-

023.scf(l>14) GCCGCATGAAACCC

>'990809A-041.scf came from CONTIG 89 at offset 0;"C:\export\EG_DB\990809a\990809A- 041.scf(5>17)

ATTTGAAAACCCC

>'990820A-045.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-045.scf(58>535) AGGCACGAGGCAGAGACGCAGCAGCGGCTCCCTCTGCCCACACCCACCGCGCCCTCGCGC

TCGCCTCTCCTTCCGGAGCCAGTCCGTGCTACCGCAGGCGCCCAGTCCACCACCACCCTCT GCAGCCATGTGCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGATGTTCGGCGGCCCCG GCACCGGAGTCGGGCGAGCTCCACCCGGAGCTACGTGACCACATCCACCCGCACCTACAG GCTGGGCAGGGCGCTGCGCCCCACCACCAGCCGCACCCTCTACACCTCGGCCCCGGGGGG GCGGGGCCCCCAGCGCTGCCTGGCCGTGCGCTGCGGGCGGCGGGCCGCGTGGGGGGGTG

GAGAATTGGGGGATTCCGGGGCCGACGCCTCACACGATTCAAGACACCGACACGGGAGG GGGGCGCAGACCCAAGCCGCTCGCAAATAAGGACAGGGGCTCTGAGAGAAAAAGAACG

>'990820A-013.scf came from CONTIG 1 at offset 3;"E:\SEQUENCE\export\EG_DB\990820a\990820A-013.scf(54>434)

CCCGCGCCAGAAACGCAGCATCGCTCCCTCTGCCCACACCCACCGCGCCCTCGTGTCTCGC CTCTCCTTGCGGAGCCAGTCCGTGCTACCGCAGTCGCCCAGTCCACCACCACCCTCTGCAG CCATGTCCACCAGGTCCGGGCCCCGGGCTCCTACCGGAGGATGGCGGGGGGCCCGGGACC GGAGGGCGGCCGAGCTTCACCGGGGCTACGTGACCACATCCACCGGACCTACAGGCGGG GAAGGGCGCCGGGGCCCACCCCCGCCGGACCCTTACACCGGGGCCGGGGGGGGGGCCCC

CCCCGCCCCGGGCCGGGGGCGGGGGGGGGGGGGCGGGGGGGGGGGGGGGGGCGGGGGC TTGGGGGGCGGCCCCCAAACCAA

>'990820A-002.scf came from CONTIG 2 at offset 0; "E:\SEQUENCE\export\EG_DB\990820a\990820A-002.scf (62>518)

GGGCGGGGCGTGGTTTTTTTTTTTTTTTTTTTTAGCGGGGTGGCTAGGGGGCTTC TTTTATTTTGTAAATATATAAGATACCTTTTTTTTGTTTTTATTTGTT

ATTGGCTTTTTATGGTGGGGGACATGGGGGGAAAGGGGGGAACCCCATGCATGGCGCACT CCCCCCCAGGGGGGGGGGGGGGGGGAAAGGGGCGGAAAACCCCGGGGCTCCTGGTGCAA AAGCTTCCCGGGACAGGGTCCAAATGCAGGAACCAAAGGGGCCGGGGAGGCGGGGGGGG

AACCGCGGAGGGGTTCACTCTTGGGAGGACATAACATGATTCGGCCCCAACTTCCCCACC CGGGGTAAAAATTTCTAAAACCCCCGGTTGGACTGGGGGGCGGGGGGGCCGGGCCCGGG TGGGTGGAAACAGGGGCCCAAAAAAAAAAGCGACC >'990820A-043.scf came from CONTIG 3 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-043.scf(58>460)

TGGCACGAGGGAAAAGGTGGCTGGTGGTGAGTTGCTGGGTTCCTCCCTGGTGCCTACTGG GTTTTCCCAGGGTGGCTGGTTGGGGCGGAGGGCGGGGCCCCCCCGGCCCCCTTTTGGGAA AATGCCTGGGACCCCCCTTGGCCCCCTCCCTGGCGCCTGGGTGGGAAAAAAAAGGGAGCA AAAAAGGCCCCCGGCGGGGGAAGAATGGGGCCCCGGTTGGGGGGGCCCCGGGGGAAGGG

CCGGGGCCCCCCTGGTCCCCCCCTGGGCCCCGGGTGGGGGGAGAAAAAGAGGCCCCGTGG GGGCGGACGGGCACCTGGTTGGGGGCTCCCGGGGACCTCCCTGGAACCCTAAAGGAATTT GGTGGGACAGGGGGGGGGGGGGGGGGGGACGGGCCCGGGCCAAA ' >'990820A-035.scf came from CONTIG 4 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-035.scf(60>530) GCACGAGGGTTTTTTTTTITTTTTTTT^^

ATTAGGGGGGAGGTTCGGAACAAGGAAGAAAGGGGGGGGAGGAGGGAGGGAGGGGGGG GGAGGAGAACACCAAGCCGGGGTAGGTGGGCCACGGCCAGAGGGAAAAAGGGGGCCCC GGGATGGAAGGGGAGCGGGGAGGGGGACGGGGGGCAGGCAACAGGAGGGGGACACGGA GAGGGGGGGGGGGTAGGGGACAAGGGGACCCCACATCCCCGCCGGTCCAATGGTAACAG AACAACCAAAGCCCCGGGGGGGACAAGGGGGGCAACTTGCGTTGGAACAGGGTTAAAAT CGGGGAAGGGTGACCAACGCCCTTGGCGGGGGGTGGAGAAAAAAAAAAGAAAAAACCCC CGGACAAAAAGACCCCATTATGTTGGTGGAGAGGGGAAGTGGGGGGGAACCCACGN

>'990820A-014.scf came from CONTIG 5 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-014.scf(56>446)

GCACGAGGGTTTTTTTTTTTTTTTTT^ ACTAAAGAAAGAACTTAAGTTGATGTTTTGTTACAACTTATAGAAAAGATGAAGGTAACC

CAAATATGGCTGCACTGCCTTGGGGACCAGGGAAGGCACCCCTGTGGGTGTGGGAAACCA GCCTGGGGCTTTAGTTTCACTGGGGCCAGGGTGTGCTTGGGAAAGGGGACCTCTGCCTTGC CAGATCCCGGAGCCCCCCTCTTGGGCCAGGTGGTTTTGGGGGCACCCATTTTTTGGTGGTT TCCCCCGTCTATTAAGGAAGGGGTTAAAGAAAACACAAAGGGGTTATTTTTTTAGGGGGG TGGGGGGGGCCGGGGGCGGTTCCACCT

>'990820A-01 l.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-011.scf (60>496) GCACGAGGGTTTTTTTTTTTTTTTTTTGCTGTACTGAGCAGCATGTGGGAACC^ TGGTCCAGGGGATTGAACCTGGGCCCCCTGCAGTAGAAGTACAGAGTTAACCACTGGAAC

TGGTACCAGGGTATTTCCACACATAGATTTTAGGAGCTTTGTGCTGTATGCTTAAATGCTG GCATTCCAGAGATAACATGAAGACAAACTGGGTTGGAGAGTCTCATCATCTGTTTTCCCCT CCGGGGCTGGCCATAGAAGACTGAAATCCAGGGAAGAAAGATGCTGCAGCAGCAGAGAG CGCTGATTCAAACTACCTGCTTACAGGCATGCTCGACGGCAGAGGCAGGCGGGGCTAAAC AAACCGGGGACTATGTTTCTAATTGAAATACGTGTGGGCTTTCCTTGTTGGCCGGGGCAGG

AAGGAACGAGTGG

>'990820A-003.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-003.scf(61>525) GCACGAGGGTTTTTTTTTTTTTT^

ACAGATTTTTGGTCAAGTTGTTTTCATTAAAAAGTACTGATTTTAAAAACTAATAACTT ACTGCCACACACAAAACATATGGTCCACAAAAACATTCTCCTTTCCTTCTGAAGGTTTTAC GATGCATTGTTATCATTAACCAGTCTTTTACTATTAAACTTAAATGGCCAATTGAGACAAA CAGTTCTGAGACCGTCCTTCCACCACTGATTAAGACTGGGGTGGCGGTATTTGGGGATATA TTCATTTACCTTTTGACTTTTTGGCAGACTGGGACCTTCCACCCCAGCGCCTCCTGCCATGT

TTTGAGACCCCCGCGATGTTTGTTAGTCCGCCAGAAACGCCAGGGAGGAATAAAGAACTT TGCCCATGGGTTGCCGACCTTAACGTGGGGGGGCCC

>'990820A-038.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-038.scf(50>535)

CTTGGCATTTGGAAGGTACTCCCCGGATGGACATCGCTTGGGCCTTGAGATTCTTTGCCAT AGACCCTAAACCACCACACAACTGCAACCAACCACTTTACGAGGGTTCCCCTCTCTGTCAA TTTTACAGAGGCCTACCCCTTCCCCTAGTTTCTTTTTGCCATCAACCTTAATAAGGTGATTT GAAGCTCAGCACAAAGGGCCCTCACCAACTTGACATACATTAGCTCATCACAGTGGGATG

CGAGCACACACAGAGGGGCTTGGCGCTTGGGCTAAGCTTCGAGATTCCGATTCCAGGCTA GCCATGGGATGAGGCGCCTCAGCCCCTGCGAAAGATAACGCCTTACACCCCGCACATGCC TCCTGCCTGGGGGGGTAGGGGGGGCAAACTGATGCCCGACCTCCCCCCGCGTCCCGGTGN >'990820A-072.scf came from CONTIG 9 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-072.scf(9>114)

TTTTTGTTTGTGTTTGGTTTTTTTTT^ >'990820A-096.scf came from CONTIG 10 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-096.scf(55>399) GTCTCGAGTTTTTTTTTTTTTTTT^

CACTGTCCCCAGCCATGATGTAAAGGGCACAGACTTTGGGGTTGTCATAGGATCCCTTGAC AAATTCGATGTAGAGTTTGCCTGGGAAGGTGGACACCTCGCCCTGGACGCTCAGCTTCCCC TTCCGGATGCTCATCGGGATGATCTCATCATGGGCAGTACTGGGCCCTACAAGATCAAAG

ATATCCAGGCCCTTCACCACCCCGTGGCCGGTCAACCGCACGTAAAACACCTTTTGTTGGG

ACGGGCCAAGAAGACCCAAAGAACTTAACACCGCACGTAG >'990820A-062.scf came from CONTIG 11 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-062.scf(56>435)

AAGCCTCATGTGTATGAGTGTTTTCCCCTCAGACTGCACACCTTTCATCTCTTGTAGCTGCT CTGCCGTAGAGTTGCACAGATCTTCATGGTGAGCAATTAAGAAATTTTAGTGAAAAGTAG ATAACAATTTCAGAAATCAGTTTCTCTGGTCTTTTGTAATACTGTTTGGCTTCCCATGGCTT TTTTTGGAGTTGTTTATTGAATATGTGGTTTTGACAGCCTCCTCATTACAGTTTCTTAAATG

CATACTGGTTTGTAAAGAATTATTGACGTTATTCATTCCATTTATGAGAAAAGAGAGAACA GCTAATAAAACTTATTGGAAAATCGGAAAAAAAAAAAAAAAAAAACTGAGGGGGGCCCG TACCCCATCGCCTT >'990820A-050.scf came from CONTIG 12 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-050.scf(60>520) GCACGAGGTCGAGTTTTTTTTTTTTTTTTT^

CAATAGATTGAGTATTAAGCAGTTCTTGAAAGAATGAGGGGGGAAGAAGAAAAGCCCAA GTGAATAAAACATTGAAACTATTCCCCTTTGAAAATAAATTCTAAAATGATGCGGAATGT GAAATAAGCTTTAAACATAGGGGATCCGAGTTTATAGATAGAAACAAAAAGTAGTCCTTN

ATGAAATAAGGTTACAAGAACATGTGGCTGTTTTTCCCTGTTATAACTGGAAGCGAGAAG AGACGAGTTTGGGACGAAATAGCGACTCAGATCACTTTCCTTCACAGCTGACCCAAGCAG CTGAGTGCCGAGCTGTGAAGGAACCAAGCAACGGGCCGGGGGGACGAACGCGGGCCGCT GCAGAACACGGGCGACATAACAAGGGGGCTCGAGCTGTGTT

>'990820A-001.scf came from CONTIG 13 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-001.scf(l l>536)

GGGCGGGCGTCTTATATTTGGATCCCCCGGGCTGGGGGGAGCGAGGCGGGAACGGGGCGT TGGGTCTGTCGTTTGGGCCGCCCAGACACCTTTACTGTAAAGATGGTCAACGTACCTAAAA CCCCCAGGACTTTTTGTTGGAAGGGTGGAAAGCATCAGCCTCACAAAGTGACCCAGGATA

AGAAGGGGCAAAGGATTGCCTGGGTGCCCAGGGAAAGAGGCGCCTTGGATCGGGAGCAA AGGGGGTCCCGGGGGGCAAAACCAAGCCAATTTTTCCGGAAGAAGGGGTAAACCACCAA GAAAAAGGTGGCGAGACTTGGATGCGTGGGGCCCAACTTGCGGATCCAAAAGGATGCTG GCCTTTAAAAGGGGCGGCCTTTTGGAATTGGGGAGAAAAGAAAAAAGGGCCCAGGTTCCC TTTAAATTTGGGTTTTTTGTTTTTTTπ

ATTTGGGTTTTCTTTTAAAAAAAAAAAAAATGGGGGGGGGCGGGCTT

>'990820A-079.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-079.scf(54>478) TTTTTTTTTTCGTAAAAACCTGTTTTTAATTTTGTATAAAACA^

GGGGGCTGTAGGGAGAATTCAAGCTAGACCAGCTGGNGGTGGGGGGTCACAGGCCTACC TCGGGGGGGGGGACGGGCCCTGGAGGGGGGACAGGGAAGGCATGGCAGGGGGCCCAAG GCCCACAGAGCACCCCGGGCCGCCCCCCCGCCCCGGGGGCAGGAGACTAGCCCCTCCGGG GGCCCCCCTTGGGGGTGCGGGGGGGGGCCCCAGGCCCCGCAGCCTCTAACAAGACGAGA GAAAAGGGGGAAGGGGGGAAAGCACCAGGGAGGGAGAACCCTGGGGCCCCCGGCTGCG

GGGGGCCGCTTCCCCCTACAACCCCCAGCTTCTGGCCAGGCGGCGCACAACTGCACAGGC CCTGTGGGC

>'990820A-015.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-015.scf(60>454)

GGACGAGGGCGGGAACGTGCTGGACCCTCTGTGCCAGCTGGGCAACCCCCAGCTTCGGGT TTTTCGCACCAACTTCTTCATCCAGGGTGGGTGCGGGGCCGGCACCGGGCCCAGCCCCGA GGGATACCCGTGGCAGGGTCCCGGATCCCCCATGGAAGGATGGACCAGAAGTGGACCCTC AGGAAACTACCTCGGGCGCGGTTACCATGTGCGGGGGGCCGCCGGGGGGGCGAGGGGGG AGGAACGGGTCCAAAAAGGAGGAGGGAACACAGGAACGTAGGGATAAAAAAGCCAGAT

TTTAAGGGGGCCTCGGGGCAGTGGGACAGGGAGAACTTTTAATTTCCAGAATTTGTTTCCT AGGGGGAAGGGGGCCGGGGGGGGTCGGGGGGGGGGAC >'990820A-009.scf came from CONTIG 15 at offset

368;"E:\SEQUENCE\export\EG_DB\990820a\990820A-009.scf(60>430)

GGACGAGGGGGGGGTCGGGGGGGGGACCGGGCCCTGCTGGGTCCTGCTTGGGCCCATTG

GTCCCCCTTGGGTGCCCGGGGGCCCCCCTGGAACCCCAAGGGCCCGGGGGGGGAAGGGG

GGGGGAAAGGGGGAAAAGGGGGACAAGAGGGAAATAAGGGGGGACCGGGGGTGTTTTT

GGTGTTCAGGGGGCCCCCCCGGGCCTTCCCGGCTTTGCTGGGGAGCAAGGGGTCTTTTCGG

GACCTTTGGGTGCTGGTGGGTCCCCGCCGGTGCCCCCGGGGTTTTTGCGGGGTNTTCCGGC

GAAAAAGGGACTGAAGGGCTGGCCCAGCCCCTTTGGGCCCCCGGGGGCCAAAGGCGGGA

TGGGGATGGTGGGG

>'990820A-019.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-019.scf(60>343)

GCACGAGGGGGGGGCGGGGTGCCGGGTTTGGGGCGCGACGCCGAAGGCGTGGGAGGAAG GCGGAGTGGGGGCCGGCCGGGGGCCGTCTTTTGGGAACGGCAACGAACAGGAAGTTGGG GCCCCCCCGGGCCCGGGGCGGACGGGGGGGGGGTGGGGGGGGAAGGGGGGTCGGGGGG

GGGCCCGGCCCCTGGGGGGGTTTGTGGGCTTGAAATTCCCAAAGGGGGGGAACCCTGGCC CCCCCCACATAATTCTTCCTGGGGGTGCAAGGGGGGGGGGGGGCGCCG

>'990820A-094.scf came from CONTIG 17 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-094.scf(59>475)

GGGGACGAGGAGAAGCCATTAGAGGTTGGGCCCCATGCACAGATGGAATAGACTACACC AATCATTCAAACACCCTCCCTTCTTGGTTACTTTGCACGACTTGCAAATGAGGAGAAGAAG AAAAAAATCGCTGCACCCCAACCAAGGACACTGAGTGGCAGAGCAAACCTGGCACTTTGC GTGGAAGAAGATGCACCTGAAATTCTGGCAAAAAGCAAGACCGGGGGCCTGATGGGAAG ACATGGTTATGGGCCGGACCCCCCGGAGCACATAAATGGGGGGGACCAGAATCAGCCCTC

TTTAAAGTGGGGGATGGAAAAGTGTATGGGACTGGAAACCCGGGGGCTAAGGGGGGGGG TGGGGGGGTAAAGGTTTTAGGGGGGGGGAAGGGGGGGGTTTTCGGTGGGGGGCGAGCCC

>'990820A-005.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-005.scf (118>329)

TGTCTTTCCACTTCAGGGATGACCCTTTCCCAACGACGTGAATCTCGCAAGGCTTCCTCCC TTTTGTTAACGAATGGGACGTCTGGCGGGAGAGTCCGGGGGTTCAGCACACGCTTGGAGG TGGTGGGCCCCATGGGGACCTGTACTGGCTTGGCCGGCTGTGTGTGTGGACGGCGCTTTCG GGGCGACTTTGGGGGGGCCCAAAGTCCCCA

>'990820A-017.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-017.scf(60>389)

GGCACGAGGAAGTACTTCTTGTCCTGGGAAAATTCCCATGGGATGGGAGGGACGCCTGGG TAGGTCTTACAGGTCTATGTGGGTGCGCAAAAGAGGTCGGGACGGCGACCTGAAGTGAAC TTTCACATTAAAGGCTGGTCACCCATTGTTTGCATACATTTTTATGGTTCTTTGAGTTTTGT

TAAGGTTCTTATGACTTTTTTTCTGGGGGCTTTTCCTGGGTGGGCTAAAGAGGGTTTAAAG CCGTCCGGCCTGGCAATGCCAGAAAGACCCCAGGGTTCAATTCCCTGGGGTTGGGAAAGA TCNCCCTTGGAAAAGGGAAATGGGAAA >'990820A-008.scf came from CONTIG 20 at offset

0;*Ε:\SEQUENCE\export\EG_DB\990820a\990820A-008.scf(55>287)

AAAACATCACGTTGGGAGAACCGCCTGGGGTTTTGCACTCGGGNGGGGGGTATTTTGGGG ACCTTTACTGGGCAGCTCCTGAAAGGCGAGACACTTGTGAACATTCAAGTGAAGCAAAAG CCTTTCATGATTACAGTGCAGCAGCCGCCCCGAGCCCCGTGCTTGGCAACATTCCCCCAAG GATGGGAGGGCGGGAGGGCCCATTCCTCCGGTTTTTTTTTAGCTTTTTT^

>'990820A-004.scf came from CONTIG 21 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-004.scf(209>270)

CCGGGAACCCAAAGGGATTTTTTCTGTTTGCTGAGATTATACTATGCCTGGAGATTCTGAT C

>'990820A-016.scf came from CONTIG 22 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-016.scf(54>535) GTCCACAGGCGTGCTGGGCTCCCCGCTCATCTCACTGCTCTTCTGGATCCTCATCTGCTTCT CCATCGCGGCCCTGTTCACCAAGCGCTACAGCATCCGCCCCCTCATCGTGGCGCTCATCCT GCGTTCCATCTACTACCTGGGCATTGNGCCCACGCTCAACATCCTGGGTGCCCTCAACCTG ACCAACAAGATCGGGGTCGTGGGGAGCTTTGTGGGCAACCGTGGCACCTTCATCCGGGGC TATAAGGCCATGGGCATGGACATGGAGTTCCTTACCACGTGGGCTACATTCTAACGGGGT

GTTTTGGCCCTTTGGCCCCGAGCCTTTTACGGATTCTGTTTTTTACCCTTT CCTGGAAAAGGGAAAAAAAGGGACCCGAAGGCCGCCAACTGCTGCCGCCGGTGGCCCCA TCGGCTACCTTTTCTTTGGGGTTCCTTCCAAGAACATTTATCTTGGGGGCCGGTGCC >'990820A-033.scf came from CONTIG 23 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-033.scf(54>544)

CGCCGCGCACGCCATGGGAGGCCGGGGACTGACGACGAAGTCATACGGTAAGCGTCGTCC TAATCGGATGGAGGATGGTGGCTGGGAGATGAATCGGAAGAATTATATCTGCTGGTGAAA AGTTTCATTAAATGGTGCAACTCAGGATCTCAGGAAGAGGGATACAGCCAGTACCAACGT ATGCTGAGCACGCTGTCCCAGTGGGAATTTTCAATGGGCAAAACTTTGCTGGTATATGATA

TGAATCTCAGAGAAATGGAAAATTATGAAAAAATTTACAAGAGATAGAATGGTGCATTGC TGGGAGCCCATGAAAAAATTGCTGAGTGCAAAAGCCAATTCTTCAGCAAAACGATACAAA AAATGGCAGATAGATGCACTGGCAAGGGATCCACACATCAGCAGCCCCAACGCAAAAGA CTCGGGCCTGGAAAGAATAGACTCTTAAAATTAAGAGGGNGAAGAAACGGAAAGAACGA ACGCCCAGGCTC

>'990820A-020.scf came from CONTIG 24 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-020.scf(60>504)

GCACGAGGCAGAGGTGCAACTTTCTTCGGTACGTCCCGAATCCGGGTTCATCCGACACCA GCCGCCTCCACCATGGCCGCCTAAGTTTCGACCCCAACGAGATAAAAGTCGTGGACCTGA

GGTGCACCGGTGGGGAAGACGGTGCCACGTCTGCCCTGGCCCCCAAGATCGGCCCTCTGG GTCTGTCTGCAAAAAAGGGCGGTGATGACATCGCCAGGGCAACGGTGGTTGGAAGGGTCT GAGGATTACAGGGAAACTGACCATTNCAAACAGACAGGCCCAGATGGGGGGGGCCTTTG GCTTTGCCTTGATCTTCAAGCCCCAAGGACCCCCAGGAAAGAAGAAAAAAAAAATTAAAC CAAGAACATTTTTTTGAGAATGAAATTGCCGGGGAGCGTTGGGGTTTATTGGAATTTGGG

ACATAGGGAATCGGGACGGCGGGGGG

>'990820A-010.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-010.scf(60>532) GCACGAGGCTGTGTTCTGGGGAGAGGAGCACCACTCCGGACATTACTGGCTACATAATCA

CCACCACCCCAACAGACGCGCCAGCAGGCGATACGTGCTCTGGAGGAAGAGGGGCATGC GGATCAGAGTTCCTGCACCTTTGAAAACCTGAGTCCGGGCCTGTTGTACAATGTTCAGTGT TTACACTGGCAAAGATGACAAGGAAAGAGTCCATATGTCTGATACCATCTTTCCATCTGTC CCTCCTCCCAGTGATTGGCGATTTACCAATGTTGGCCCTGACACATGCGTGGCACCTGGCC TCCACCTCATCCATCGAACGACCACCTCTGTTCGCTCTGGCTGGGAAAAAGAGGGAGGTG

CCGGCTGCCTTΓCTCCTCAACAACCAGGATTTAAAATTCTGCCGGCCCGACTTTATAAGGT TCAAGGTAAAGAAAAGAAGCAACTTTAAGAAGAAAAAACGCTTGATTCCC

>'990820A-007.scf came from CONTIG 26 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-007.scf(58>532)

TGGGACGAGGGGGGGCCTGGGGGCTAAAGGGAGAAAGAGGACGGCTCCTGGGGGGGGA ATGGGGGTAGGGATGGCCGCTCCCGGGAGCCCGCGCGACCGCGCCGGGAGGGTTTTGTGG CCTGCCGGCTCCCCCAGGGCCCCCAAAGGTGTGAAAGGGGGAACGTGGGCAGGTCCTGGT GGGTCCTGGTGGCTGGTGGGTTGCCCGGTGGGTCGGGGGGCCTCCTGGCCCCTCCTGGGA GGAATGGGTTACCCCACGCCCCCCCAGGCTCCAGGGGGGGCTCCAGGGCAAAGATGGGCC

CCCCAAGGTCCACCCTGGCAGGTATTGGGGCTTGTTGGGAAGCCCGGGATTCTCTGGACC AAGGGGGTTTTTTGTGACCAGAGGGGAGGGGGGACCCGGGCCCCAGGGGCCTTCGGGGG CTCAGCCCACTAGAATTGATGATTATTGGAGCCCAAGGTTGAGGCCCCCAGGCTCTAG >'990820A-023.scf came from CONTIG 27 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-023.scf(60>543)

GCACGAGGGTGAGGCGGGGTGGGGGCGGAAGCACGGGTCTCCAGCGGCTCGACTGGGGA GTTTTTGGCTGGAGCAACGGGGAGCACCATTGGATATCTGGACTTGGTATGACGAGTTTTG GGGAATTACATCGGAACCAGAGCTTGATTCTGATGAAGAATGATGATTGAATTGGGCAGA GAGACCAAAGATCTTGATGAGGTCGAAGAGGACGAGGACGACGACGAGGGGGCCGAACA CAACGAAAAACACCCTGGGTGGTGGGGGGGGTGCAGCAAGACAAAAAGACCACCCCACC GCCGGGGGGGGGGACGGCCCCAAGGGGGACCATAGTAAGAGGAAGACACCAGCCCTCCA AAACCATATTAAGCAGGAAACCAAAAATTACTCGATGAGCAGAGTCCTGCACGGGGCGC AATGGTTΓΓGGCGGAATGATGAAATCGGCTTATAAAATGGACCTTTGGGCTCTGACCCGA

AGAAGTTT

>'990820A-031.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-031.scf(54>351) CTGCCTGCAGGGGCATCCTGAGTGTGGATTCCACTGTCAGCTCCTCTCCTTCCACCTGTGC

TGTGACTCCGAGGGATATGTACGTTGCACTTTCTCCCAGAAAATCTGGGCCAAGTGCTGTG AACCGGGGGAATGGAGAAGGCTAGAGGGAGACCCACTACCACCTTCAAAGACCTGTGCC CAGAGAAACCCAAGGGGGGAAGAAAAGCTGGCATCGCGGCGNGGGTCTCAGGAGATACC CGATAGAGACTGACAGCTTTGATGTGCCCTGTACCCCAGTGCTTTGCTTACAGGAGGT

>'990820A-027.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-027.scf(60>518)

GCACGAGGGGGTCCTGGACAGCATAAGCATCATTGACACGCCGGGGTATCCTGTCTGGAG GAGAAGCAGCGGCATCAGCAGAGGGTATGACTTTGCGGCCGTCCTCGAGTGGTTTGCCGA GCGGGTGGACCGTATCATCCTGCTCTTTGACGCCCACAAGCTGGACATCTCTGACGAGTTC

TCAGAGGTCATCAAGGCCCTCAGGACCACGAGAACAAGATCCGTGTGGGGCTGAACAAG GCCGACCAGATTGAGACGCAGCAGCTGATGCGGGGCTACGGGCCCTCATGGGGCCCCTGG GAAGATCATCAACACCCCGAGGGGTCCGGGTGACATTGGCTCTTTGTCCCACCGCTCTCAT CCCGACACGCAGCTTTGAGCTGAGAGAGACTCTTAAGAATCAGCTTGCCCGAAGCGCCCT AGAGCTATGACTATAAAGGGCGGGGCCAGGCAGCGATT

>'990820A-022.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-022.scf(55>247)

TTTAAGTACGAGGGTGAGGTGAGGGGGGGGGAAGCACGCAATCCACCGGCCGACTGTGA GTTTTTGGTTGGAGGAAGGAGAGCACCATGGATACTGAGTTGAATGACGAGTTCGGGAAT

GACATCGCACCAGAGTGGGCCGGTGGAGGAGAGGATGTTGAAAAGGGCTGAGGGACCAA AGATGTTGATGAGGT

>'990820A-029.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-029.scf(60>526)

GCACGAGGAGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCTCCGGGCTCCTGCTAAG CCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTACCGGGACCTCATTAGC CATGACGAGATGTTCTCCGACATCTACAAGATCCGGGAGGTCGCGGACGGGCTGGGCTGG GAGGTGGAGGGGGAAGATGGTCAGTAGGACAGAGGGTAACATCGATGACTCGCTCATTG GTGAAATGCCTCGCTGAAGGCCCGAGGCGAAGGGTACGAAAGCACAGGATCACTGGTGT

CGATATTGTCATGAACATCACTGCAGAAAACAGCTNACAAAGAAGCCACAGAAGACATA AAGATACAGAAGGCAACAAGGAAACTGAAGAAAAGACAAAGAGAAAACTTTTGAAGGG GCGCAAACAAACAGCCAACTGCTATTAAAACATAAGCTTAGGGGAAAAGAT >'990820A-021.scf came from CONTIG 32 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-021.scf(54>537)

CTTAATTCTTCTATGTCCAATGGGAACAAGCGATGCTGGACCCTTTTCGATTCACATGGAT GATATGAGATGGACGGAAGGGGNAGGCCGAGGGTCGGTGGGAAAGAGCACAATGAGTGT TATCATGCCATCTGTTGGTCACAGNGTTAAACTTGGAATGGATCTTACGAAGGTAGTTCTT CCAACATTTATTCTTGAAAGAAGATCTCTTTTAGAAATGTATGCAGACTTTTTTGCTC

GGCCCTGTTTGTGAGTATTAGGGACCAAAGGATGCCAGGACCGAATGGTTAAGGTGTGAA AATGTATTTTTCACCCTTTCACGCAGAAGAAAGGACGGTGGCCAAAAGCCACCAACCCCT TGGGCGAAATTTAGGGCACTGACATACAAAGAACGAGAGAGGGGGCAGGCCAAAGACAG TCCTGGTTCCAGAAAAGAACATTGGGGCGGCAGTTCCACATCCCCCTTACTTTTTGCGGGG G

>'990820A-032.scf came from CONTIG 33 at offset 0;'Ε:\SEQUENCE\export\EG_DB\990820a\990820A-032.scf(54>526) TGCCCGTGAACCTGCTCCGAGCCGGCCGCATCTTCGTGTTCGAGCCACCCCCGGGCGTGAA GGCCAACATGCTGAGGACCTTCAGCAGCATCCCCGTGTCTCGGATATGCAAGTCTCCCAAT GAGCGTGCTCGCTTGTACTTCCTGCTGGCCTGGNTCCACGCCGACATCCAGGAGCGCTTAC GATACGCACCCCTGGGCTGGGCGAAGAAGGATGAGTTCGGGGAGTCTGACCTGCGCTCGG CCTGCGACACGGGGGACACGTGGCTGGACGACACAGACAAGGGAGACAGAACATCTCGC

CAGACAGATCCCCGGTCCGGGCTCAGACCCTGTGGCCCATGCTNTATGGGGCGGGGGACA CGAGTCGACAGCGCTGCTACACTTCCTGACGCCGTCACACCGGGTTNGAAGGNGGTCAGC TGGCTGCAGGCGAGCACAGGACATCAAGCGGCGCATAGCGAAGGATGGCAT >'990820A-028.scf came from CONTIG 34 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-028.scf(60>520)

GCACGAGGGTCATTGCTGGTTCTGGATTTTTGGCACGTCTTTGGGTCTCATGTTGCTAACC CAACACCACAGGACTTAAGGCTGTCAGGAACAGTTCTTATTTGGGATTCAGAGCAATTAC TGAAGAAGGATTATGTTCTTGTGAGAAAACGAATTTATGATTCAGAAACCCCTAAAGACA AGGTACTAAGCAACAAAATATGCAΛACAGATGTTGNTAATTAACTGTCATTTTTGTCTTAC

AGCTGTTTGCAGACAAAGATCCAAAGACAGCAGATTAGTTTTACAAAGGGTATCTGATTA TTACTTTGTTGTGNGTGTCTCCTTTTGTCCTTATAATAGTTATATCTTTAATTTACAGAAAC TTCGGCTTGACACTGAGAGAAGATTGGTTAAAGTCCTGTTTACAATATTCGGTTTTGGCAG GATGAAAACGTACTCTGGTTGCTATTAGATGACTGN

>'990820A-034.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-034.scf(60>526)

GCACGAGGGCCGGCTCTGGGTGGTCAGGCCTTGCGAAGCTGACCTGGAGGAGAACATTAA GAAAGGCAAAAAGTGCATCCGGACCCCCAAAATCTCCAAGCCTATCAAGTTTGAGCTTTC TGGCTGCACCAGCATGAAGACATACCGAGCTAAATTCTGCGGAGGGTGCACAGACGGGCG

GCGCTGCCACCCCCCACAGAACCACCACCCTTCCGNGGAGGTTCAAGTGGCCTGATGGGG AGGGCATGAAGAAGAGCATGAGGTTCATCAAGACCGCGCCTGCCATTACACCGCCCCGAG ACATGACTCTTTGGGCCCTGACTACAGAAGATGATGGGGACAGGCCTAAGCCGGGCAGGG GACCGGAACATTTTGCTGGCCTGAATGTTCCATTATTTTGGTCCCGGGGTTCAGGCCCAGT TTTTAATGGGTTTAAGGGAAAAAAAATCCCCAAATAAAATGGGCTT

>'990820A-037.scf came from CONTIG 36 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-037.scf(ll>408)

AATTCGGGCTCTGTACAACTAGATGATCTACAGGGCTGCTGGAATTATGCACGATTGTCTA TTCTATATTGTTCACCCAATTATCTTGTGCGTAATAATGGTTGATACTTGTTGTCCTGTGGG

GAAATATGTTATGCCGGTCTACAATTGCACATCATTGTAACGAAGGCGGAAAACATAAAG ATGTAGAAGCGTGGGGAAGGGCTAAAGGAAGGAGGCTCAAGTGAAATTAATGTGCGATG GGGGTCCCTGCCCCCGCTTTCCCGGGGGCCAAGACCTACCCCGGCCAAGGTGGTTTTAAC GAAAGNGGAACATCGGGGCGAGGAGAGGCGGCGTTTTGCTCCTTTTCGCCTCTTTTGGTTT CTTTTGTTAAATTAAAAAAGTATTGTTGGAAAAAA

>'990820A-039.scf came from CONTIG 37 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-039.scf(60>580)

GCACGAGGACCCCAGGGCCTGATGGGAAACAAGGGTGGAACCGGGGGGTGGTTGGGCGG CTCCAGGGCACTGTTGGGCCCATTATGGGTCCTTAGCGGGACTCCCCAGGGAGAGAGGGG

GTGCGGGCTGGGCATTCCTGGAAGGCAAGGGGAGAAAAAGGGTGAAAACTGGGCTCAGA GGGTGACATTTGGGAGCCCCTGGTAGAGAAGGTGGCTCGTGGGGGCTTCTGGTGGCTATT GTGGGCTCCTTGGCCCCTGCTGGAGCCAAAGGGGGACCGGCGGTGAAAACTTGTCCCGCT GGCCCTGCTGGCCCCTGCTGGTCCTCGGGGTAGCCCCTGGGAACGGTGGGGAGGCCGGGC CCCGCTGGCCCCAACGAATTTGTGGTNCCGGTGGGCTGGTGGTCACCTGTGCTAAAGAAA

AAAAGAACCAAAGACCAAGGGGAAATGGCCTGTGGCCCCCAGCCCCGGGGACCGGCGGC CGCTGCCAAAGCCCCCTGGCCTGCGGAAGCGGGGAGGAGGGCCC

>'990820A-040.scf came from CONTIG 38 at offset 0; "E:\SEQUENCE\export\EG_DB\990820a\990820A-040.scf (55>520)

GGACAAAATCTACTTCATGGCTGGGGCCAGCAGGAAAGAGGCCGAATCTTCTCCCTTTGT TGAGCGACTTCTGAAAAAGGGCTATGAAGTGATTTATCTCACAGAACCTGTGGACGAATA CTGCATTCAGGCTCTTTCCGGTTCGACGGGAAGAGGTTCCAGAATGTTGCCAAAGAAGGA GTGAAGTTGATGAAAGTGAGAAAAGGAGGAGAGGCGCGAAAGCAGTGAGAAAGAAATT GGGCCTCTGCTAAATGGATGAAAGATAAAGCCCTCAGGACAAGACGGGAAGGCTGGGGG

GCTGACCGCCTGACAGAAGCTCGGGGGCCTGGAGCCGCCGNCGGGGGGTGGGCACTGAG AGGTCAGAAAGCCAGCTCCCGCAGCANGCCTCTCACCATTTTTTGCGGCCAAGAAAATTG AATTACCCCACCCCCCTATCGGCCGCCGGGGGGAAGAGAGAAAGACAAAG

>'990820A-041.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-041.scf(60>514)

GCACGAGGATTTAGTGAGATTTATGCTCTTTAAATTACATCCGTAGATACAATGTTTATCA CTCTAAAATCATTATATAGTTTTATAATCATCTATGTATCTAGAAAAAATGATTTATTAACT GTAGGATGAAAGACCATTTGGCAGTTTCCCAGACTTTTTGACTTTATCAGATTATAAATAA

ACTATTACTGCTTACATAATGGGGGCTTAGTGTTTGCTGTTTTGAGGTCTCATTCTTAAATT TTTCCCCTTCTATAATGGATTATTAAAAGGATATTATATATAATTGGATATTATAAAGGGT TCATACTAGGCTGAAAAGATCTAGGCAAAATTAAAATATCTTTTTGTGAGAAACTATAAT AGTATTATTTGTTTTCACAAAACACTCCATGACTCCTCCTCTTTCAATTATAATTTAAACCC CCAAAACCCAGACCTTGGCTTGGGGN

>'990820A-046.scf came from CONTIG 40 at offset

0;"E:\SEQUENCE\export\EGJDB\990820a\990820A-046.scf(55>533)

TTAAAAAAAAAAAGGAAGGAAGGAAAGAAGGAGACAGGAAGGAAGTATTGAAAAAAGG ATAAAGAGCAGAAAGGAAAGGAGGAACAGAAGGAAAAAGCAAGGAATAAATAAATCAC

AGTTACTTGAAATTCATAATCAGAAGAAATGAATTATATCTCCAGCATATGTTGTATAACT CTATGCTAATAAATTTGTAGATCTATTAGAAAATGTGTGATTAATAAATGATACAAGAAA ATACAGAAGATTGGCGTTACTATGAAAGAAATGAAATATTGTTTAGTTTTTCTTGAAAGAG GGTGGGGGCCGCTGATTTTTTAGGGAATTCTTTATGCTTTCTGAACAGATAGCCTGGTTAA TTAAATACTTAGATATAAGAAAAAGAAATTGTAGGTATTTTGGGAGGCACTTACATGATT

AAAACTAAGAACCCCAAGGCTGACCATTAGACAATTTGGGAATCTAATTTAAATTCAACC

>'990820A-049.scf came from CONTIG 41 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-049.scf(60>510) GCACGAGGGCGAATCGCAGAGCTCTGCACTTCGTGTTCAAAGGGGAAACCGCTTCGAGAC

GGCGTGTTTCTATCGCGATGTCCTGGGGATGAAGATTCTTCGGCATGAGGAATTCCAGGAC GGCTGCAAAGCTGCCTGTAATGGGCCTTATGATGGGAAGTGGAGTAAAACAATGGTGGGG TATGGACCTGAGGATGATCACTTTGTCACAGAGCTGACTTACAATTACGGCATGGCAGCT ACCAGCTTGGCATGACTTCCTGGTATCACGGNGGCTCCAGGCAGCTGGCAGCACGCTAGA AGCTGAGGGGCGCTCAGGAATGGAGATGGGGGGTTGGACCAAGCCCCTGAGATTTTAGTT

TTTGCGGACGGGCCCCCTACCAACCGATAAAGAACTTGCGGGGCGACTCAAAGCCTGACA CGGCCTACTACGGGAGAAATTTGAGAGTGG

>'990820A-052.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-052.scf(57>345)

GCACGAGGGGCGAGGCTATAGGTCCATGGTAATGCTCAAGAAATGTCATGACATTGACTT TCATΓAGACAAAAAACAGCAAGCATTTTTAAACCCTGGTTGGGCCGTTTTATTTTTCTTGT GAATTTAAAAACTTTTTAAACTTTTTTTTAAGGGGGGGATGAGAGGGGGACCGGGGGGGT TTTTTTTTTGGCTTTTGGTTTTAACCAGGGGGACTTCGGGCCCAAAAA^ GGGGCACAAGGAGAATAAGGGAAAAAAACATAAACCCTTGGGGCAAG

>'990820A-053.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-053.scf(60>202)

GCACGAGGATAATATCGTAGGTTTATAAAACCTATTTATAACACTTTTTACATATATGTAC ATAGTATTGTTTGCTTTACGTGTTGACCATAAGCCTTGGGTTGAACCTTAAAGGAGCTAAG

GAACTGGAAATCTTAACTTAT

>'990820A-054.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-054.scf(60>298) GCACGAGGCCCCCGCCCATGGCTAGCCTCCTGCTCCTGCTTCTCTGCCTTGGTTGGGTGTC

TACCTTCCAGGGGCCCATGGCTGCAGACGTGGGAACTGGCTCTTCTGAGCTCAAGTGTGC AGCGCACATCGCGGGACCTGTCCTGTCAGCAGCCTGAGCTGACCGTCCTCCTCCCGAGGG CCCCGCGGGNCACAGAGAAGAAGCCCGCCCCCCCGGGCCGAGAGGCCCAAGGGTTGGA >'990820A-055.scf came from CONTIG 45 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-055.scf(51>514) TGGTTTTTTTGGAAAACCAAACATGCTTTATTTCATTTTT^

CACATATACAAAATAGGTACAATTTAATTTTTCTGCTTGTCCGAGAAACAAGACTTCTTTG GAACCATGGGAGAGGATGAAAATGAGACTGGCAAAGAACAAATGCTGAATTTAAAGAAG

AGGACAATGTTGGGCAAATGATCCACTTACTTTGGGGGAATAAGAGGAAAGGACTGATGT TAAGACAATGAAAAAAAAAACACAAACAGCTCACAGCGNGGAGGATCTTTCTCAATTCCC TAGCACATCAACATTCTCAGAATCTGAAAACTGGTATTAGCACCTGGATTTGACAAAAAC AAATACCCACTCTCCTGTCAGACTGCGGGGGACAACCACGAAGGGTTTGGGGAGTTAACT TGGAGTGGGTTAACTCCCTCGGGAGAATTAAGCCCGGGGGCA

>'990820A-056.scf came from CONTIG 46 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-056.scf(54>506)

TGAGAGCCCACAAGGACCACAGTGGAAGATCCTGGCAGAAAGGAGAGTGCCACCCAGCA CCCATCCCTCACCTTCCATATTCCTTTCTCAACACCTGCTAGGGCCTGGCAAAAGAGCTTTT

CCCAGAAGACTTAGGGGAAACCAAACTGATATTTTTTTTTGGCCAAGTCATACATCTTGCA GGATCTCATTCCCCAACCAGGGACTGAATCCAGCCCACAACAATAAAAGCGCTGAATCCT ACCCACTAGACCACCAGGGAAATTTCCAAACTGATACCTAGAAGGGGGNGGGTATTATGG AGTTTAGGCTTCCTGCGCTAAAACACCNCAACCTGCTACTGTATGGGAAAGGNAGGGACC ACACAGGAGAAGAACCACCTCAGCCCTGGAATGGGAAGAAAAATTACATGTCAGTTTTGG

GCGGAAATCAGGCCAAAAGAAAGAGACCCTC

>'990820A-057.scf came from CONTIG 47 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-057.scf(54>504) GCAAGATGATGACTTCTTGGCCACCTTGAAAGAGCTGGAAGCAACCCTCCGGACCCAGAG

CCTCTCTCTGGAGTGATTCCTGAAGGGAAGATCCTGAACAACACCTACTACCAAGAATGC CTCTTCTACCTGCACAGCTACAGCAGGCCGCCAAGAGCAGCGGGGACGCAGGGGTGGCAG ACATCTGCTCCCAGTGGCTGCTGACAAGCCGCAGCCGGGGTGCCCATGGTTCGGCCTCCA GCAGTGACCCTGGCTGCAGGCCAGACAGCGNGGGGCAGGAGGATGGCGCCTTTCAGCTCT TTCTCCGGGGGGCAGGACTTCCTGGCTCACCCAGGTGGAAGGCGGGAAGNACCCACCTGC

ATCTGAGCAGATGGACTTCCGCAGGCCAGTTTGAAAAGTGAGGCGGGGGGGGTGGCGGG AGCCGCCTTTACCAGAGGAGGGGGGGGAAGCC

>'990820A-058.scf came from CONTIG 48 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-058.scf(54>525)

CTTTTCCAAACACGGGAGCCAGGATCATGCTGTTCACTGGGGGACCCCCCACCCAGGGAA CCTGGCATGGGGGGTGGTAGATGAATTAAAGGTTCCTATTCGTTCCTGGCATGACATTGAG AAAGACAATGCCCGCTTCATGAAAAAGGCAACCAAGCACTATGAGATGCTTGCGAACCGC ACTGCTGCAAACGGTCACTGCATTGATATTTACGCCTGTGCCCTTGATCAGACTGGACTCC TGGAGATGAAGAGTTGTCCAATCGTACTGGAGGGTACATGGGGAGGGAGATTCTTTCAAC

ACTTCTCTCTTCAGCAGACATTCAAAGATTTTAGTAAGATTTATGGAATTCCGATGGGCTT TGTGTACTTGAAGAAAGACCAGGGGCGGAGGGCGGGAGCATGACCTGGGGGTTTAAAGG GAGGACGGGGGGCAAAAAGACTGGGGCGGGCAGGGCAAGGAAAATGGGCG >'990820A-059.scf came from CONTIG 49 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-059.scf(54>533)

CAGCAGCAGCAGCAGCAGCAGCAGCAGCCTCGGGGGGGGCGGCAGCAGCAGCAGCGGCG GGGCGGCCCGCGCGGGTGTTTATGTGGGGTCGCGGGGTCTCCTGGCAGCATGGCGGACTA CCTGATCAGCGGCGGCACCGGTTACGTGCCCGAGGATGGGCTCACTGCGCAGCAGCTGTT CGCCAACGCCGACGTCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTTATAGACTTC

ACAGCTGATGAAGTGGGATCTGACTTCAGCCCTGACTCGAAGATCACACTAAAGACGCCA TCATCTCATCCCCCATGGACACTGNGACGGAGGTGACATGGCCTTGCATGGCTTGATGGC GGTATGGGTTCATCACACACTGACTCAGAATTCAGCCATGAGGGCGAAGGAAGAAAATGA CAGGCTCATCAGGCCCGGGGGCTAACCCCGCTACGGGGGAGGGCGAGGCAAACCGGCGG A

>'990820A-060.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-060.scf(60>529) GCACGAGGGATCAATGGAACAGATGGAGACACTTTTCACCCGCTAAFCACCAAAGATGAA

GTCCTTTATGTCTTCCCATCTGATTTTΓGCAGGTCAGTGTATATAACTTTCAGTGACTTTGA

GAGTGCCCAGGGACTGCCTGCCTTGAGGTATAAGGGGCCTGCAGAAATATTAGCCAATAC

CTCAGACAACGCTGGCTTCTGTATACCTAAAGGAAACTGCCTGGGGTCAGGAGGTTTGAA TGTCAGCGGCTGGAAGAATGGCGCACCTATATCATGCCTTCCCACACTTCTACCAGGCAG

ATGAAAAGTTGGCTCTGGCCTGGAGGCATGCATCCAATAGGGATATCATGGGAGCTTGGG GCATCAACCCCTGCTGGATATCCTAGAGCAGCAGAGGTCCAATAATGGTATGTAGAAAAT AATGACTCATGAACAGAAAATTCAACCCGGTTCCCAGGGGGAATAAAG >'990820A-061.scf came from CONTIG 51 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-061.scf(54>521)

TCGGAGTTTGCCACTTATCGGGCATCCTTGGTGTCCGCAGCACTCTCTCCCTCTCTCTAGGG CGGCGACCTCCGGCGGCCGGAAAGTCACCATGTCCATCCTGAAGGTCCACGCCAGAGAGA TCTTTGACTCTCGTGGGAATCCCACCGTTGAGGTTGATCTCTTCACCGCGAAAGGGCTCTT CAGAGCTGCTGGGCCCAGTGGCGCCNCAACTGGAATCTATGAAGGCCTGGAGCTCCGGGA

CAATGATAAGACGCGCTACATGGGGGAAGGGGGCTCAAGGCTGGTGAGCACATCAATAA AACTATGGCGCCGCCCTGTTAGCAGAAGCTGACGCGGGGAGAGAAAGAACGACAGCGAG ATAAGAGGAAGGACAAAAAAGGCAGTTGGGCGACGCCTCGGGGGGGCTGCTGGTGCAGG TGGCGGGGGAGGGGGCCCCCACCCCCACGCCCGGGGGGAGGGGGGAAN

>'990820A-025.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-025.scf(60>249)

GCACGAGGGTTGGGGTCCGGGCCCCTCGCTTCTACCCTGACCAAAACCGAAGTCCTGACG TGTTGGGGTCCGGCCCCCTCGCTTTTACCAAGACCAAAACTGAAGTTCTGACGTGTTGGGG GCCGGACCCTCTCTTCTACCCACACTAAAACCGAAGTTCGACGTTTTAGGGGGCCACTGGG

CCCGAATC

>'990820A-066.scf came from CONTIG 53 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-066.scf(55>526) GCCTAATTTTCAAAAGAAAAACCATAAAGTTAGCTGAATAGTTTCTTTATTTACACATTGA

ATCACAACTGTCCACTTAGAAGATTTTTGTTAAAAAAAATTGTTTATGTGTCTTTACACTA

AAACAGAACTTAAAAGATGAATTTTATGGCTCATGTAACCTACAAGGTTGAGAGCAGTTA TAATTTTTACTGGCCTAGCGCCATTAAAAAGTATTTAAGATTATAGTAGGAAGTATGTAAT

TATTCATTTATATTACCTTAAACGATGGATGAACCATCACACATTTCAGCCATTAAAAGGA AAATAGAGCATCATACATGATTCAGAGACAAGCAGCGTATCACTATTAGACTAATAGAAT

TTTGTTATATTTCCACTTCTGTTTTCAGCGGACAAAGAAAACAGTGGCCGCCTGCTTGATT

AATAACCCCAAACCTTTGCTTTTAGGCGAAATAAACGAATCCAACCA

>'990820A-073.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-073.scf(60>537)

GCACGAGGCTCATGCCTGTGCTGCTGCAGGGCCAGGCCCGACTGGTGGAAGAGTGTCATG GGCGCCGGGGCAAAGCTGCTGGCCTGCGATGGCAATGAAATTGACACCATGTTTGTGGAC CGACGAGGGACAGCTGAGCCCCAGGCACAGAAGCTGGTGATCTGCTGTGAGGGGAACGC NAGCTCTATGAGGGGGGCTGCGCCTCCACACCTCTGGAAGCTGATATTCAGTCCTGGGGC TGAATCATCCAGGCTTTGCTGGAAGCACGGGGNGGCCGTTCCCACAGAATGAAGCCCACA

GCATGGATGTGGTGGGCCCAGTTGCCATTCACCGCTGGGCTTTAAGCCGAGAATTTATCCT TTTCCTGGCCATGGGGGGTCACGGTCGCGGCCGCCTGTCCTACCGGCTTATGCCGGACCTG GTGCTTCTTTGTGACCGGGCCCTGCATGAAGAATCCAAAAGTGGGGGCTGGGCCCGN >'990820A-064.scf came from CONTIG 55 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-064.scf(60>465)

GCACGAGGTTACAATGCCAGCTTGGGAAAACAGAGAGTGGTTTTCTTCTAAAGGCGATCT GACGAACTCAAAGGTCCTAGAGAAGGAGGTGTCCCGCAGCCCCACCACCAGCAGCATCAC CAGCGGCTACTTTTCCCACAGTGCCTCCAACGCCACCCTGTCCGACATGGTGGTCCCTTCC AGTGACAGCTCAGATCAGTTGGCCCTTCCAACGAAGACACAGATTCCAGCGAGCATCCGG

ACCGTCCCTTGGGCAGATTTCAGACCATCTTCAAACAAGAGTTGACAGAACTAGAAAGAG CTTGGGAAAGGATAGATGACCGGGTGCCACTCAGAAAAAGGCCTTACCAAGGGGCCCTTG CCCCCAGTTCCGGGAAAACTCAAACCTCTGTGGACGCTGGTTAGA >'990820A-063.scf came from CONTIG 56 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-063.scf(54>534)

CTTTTGTCAATTGTACCTCCATAAAACTGGGAGGAAATGAACAATAAACAGTAAAAGAGT ACAGGAAAATAAGGAATACTTTTCATTGTTTTATGAAGCAAGGTTAACACTAGCGCCGAA

CCTGATGTAAAGATTTACTAAAAAGAAAAAAAATAAACATAGCTCAGTCTTACTTTTGAT AGCTACAGGGGTAΛTTTGGCCTTCTAAGAAAAGTTTGTATGTTTTAGATTTTATACTGAAG GATTAAGGGGAAGATGTCATGATGACTTTTTTTTT^

CTTAGATTGAATATATATACCTAGATTTTGGTCTAGGTGGCCGACGCTTCTTTTTAGGGGT CTGGGAGGAGGAGGCCGCGACCTTTTTGGATATTAATTGAAATGGGGATGGACCGN

>'990820A-069.scf came from CONTIG 57 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-069.scf(56>464)

AGGCACGAGGGCGGGGGGTGAGGGAGCGACCGGGGGCCGAGTCGCCGGACCCCGGCCGG GGCGATGTGGGAGGCGGGCAGCGGTGGAGCTGGGGGCCCGGGGCTGTTGGGTATACTGTT

GGCCCTCTCGCTGTCGGGGGGCCGTGCCGCCAAGAGCGACGCGGGGCTTGTGACCTGCGT GTCGGTGTTGAAACTTGTTAAAACGCAGAAACGGGGGCGGGGTGCACTCGCACGAAATAA AATACGAATCCGCCAAGGCCAAGAGCGGGGGGACGGGGGGAGGGGCCCAAGAACCCCAA AAGTATTGCGGTTCCCGGGGGGACGGAGGCGGAGGCCCCGCGGTCCCCGGGCCGGGGAA AGGGGGAGCTGTCCACGGCTAACGAAAAACCGCCCCCCCATTCCTGCCGCTT

>'990820A-071.scf came from CONTIG 58 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-071.scf(56>459)

ACCGTGGCCGGGTGGCCGGGGTACCCGGGGAGCCAACCCCGTCCAGGTGGAAGTAGGAG AATTCGATGATGGTGCTGAGGAAACCGAAGAGGAGGTGGTGGCCGAGAACCCCTGCCAG

AACCACCACTGCAAACACGGGAAGGTGTGCGAACTGGACGAGAACAACACCCCCATGTG TGTGTGCCAGGACCCCACCAGCTGCCCTGCCCCCATCGCCGAGTTGAGAAGGTGTGCAGC AACGACAACAGACCTTCGACTCTCCTGTCACTTCTTGCCACCAGTGCACACTGGAGGGCAC CAAGAAGGCCACAACTCCACTGACTACATGGACTTGAAAACTCCCCCTGCGGGATTCGGC TGCTGAATCCCTTGGCTGGGAAGGTTAAGAAGGCGGGCGCCGGCGA

>'990820A-065.scf came from CONTIG 59 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-065.scf(54>525)

CAGCATTCCAGGTTGCTGACTCTTTCAGCAGAGCCGGGCCTACGCTTTTGCAACCATGTCT AAAGGACCTGCAGTTGGCATTGATCTTGGCACCACCTATTCTTGTGTGGGTGTCTTCCAGC

ACGGAAAGGTGGAAATAATTGCCAATGATCAGGGGAACCGAACCACCCCAAGCTATGTC GCCTTTACTGATACCGAACGGTTAATCGGTGATGCAGCAAAGAACCAAGTCGCAATGAAT CCCACCAACACGGGTTTTGATGCCCAACGACTTATTGGACGAAGATTTGATGATGCTGTTG CCAGTCTGATTGAAACATTGGCCCTCATGNGGGNGAAGAGCTGCAGCCTAAGGTCAGNAG AAACAAGGAAGACAAAGCTTTACCANAGAGTGGACCTGGCCTGCAAGAGAAGAAACGAA

AGCCACTTGGAGACGGTCCAGCTGGGCCAGCCGCTTTTTAGACTAAGGAGG

>'990820A-070.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-070.scf(54>550) CGGGGCCGAAGGGGGAGCCTATGGGCTCAGGGGCCCAACTGGGGGATCCCGCCGGCTGG

TGCTGGGTGGCCCATGGGCCCTGGGCCGGGAGGACTCGGGGAACCTGGCTTCGGCGTGAA NGCGTTTGACTCGGGTGCTTGGGTGATACGGCNGTCTTGTCATCCGGGCCTGTGCAGTTGG ACGTATCCCCTTGCACACCCTACCCCAAGGAAGAAGGAGTTGTACGCGTGTCAGAGAGGT TGCAGGACTGTTTTCAATTTGTCAGTTTGTGGATGATGGAATTTGATTTAAATCGGACCAA ATGGAATGNGAATCTGCATGTACAGAAGCATATTCCCAATCTGAGAGCAATAGCTTGCCA

TCTGGTGCCAGACAGCGGCAACCAGAAAGGACAGAGCACTATGGCCGAGCAAAAGCACT ACTTTCCTTTACTTGAAGAAATCTGAGGAAAGGGACCTGACAAAGCTATACCCCTGCGAC TTTACTCAGCGTGTGGT >'990820A-086.scf came from CONTIG 61 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-086.scf(60>445)

GCACGAGGCTCTGAACTTTTTACGAAGAAATATGGAAAAACTTTGTATGGTGAGCTTCAT GTTGAAGTGGTTTTTTTTTTTGTTGGTTTTTTGT^ GCTTGGTTTTAATAGGGGCTATGCTCTACACTCCCCTCCCCTCCCCCCGCCCCGCCCACCCC CCACCCCACTCTTAACGGCCATTAGGGTTTTACTGACCCACTGGCTTTAAAGTTCCACTCT GTTTACTACATCATAATGCTGGGTTGCGGCCTTTTTGTTTTTTTATATTATAAA^ AGTGGGGATGGGTTGGAGCCCAGCGCCCTGACCTTGGGGGGATGTAACAGGCCCGGGACC GGGGCTCGGGCCCCGACC

>'990820A-047.scf came from CONTIG 62 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-047.scf(60>514)

GCACGAGGCATGATTAATCACACTGTTCGGGCTGGCCAGTTTTTCATGCATGCAAGCTTGA CAATTGAGCACAGTCAGGCGTTTGTATTAAAAACGAAAAAGTGAAAAAACAAATTCAAA ACCTACTCAGAGGGTTCTAGTTCAAATTGTTAGTGTAAATTGTAGCCGGTTTACTGAGAAG

AGCNGTTAAAATTGGCTCACCTCAGGAGCCCGGTGGGTAACTGGCCAGGCGGAGCGCCCC TGCTGCGGGCGGGCCTCTCTACCGCCCCTGGCGACCGTGACGCGCTGGCGGGGCGCCCGC TGGGTCGGGGGGGGTGCCGGGTGGCTGGTGGAAGGGGGCAGGTTTCACATTATTCAATTT AAAAAAAATTTTTAGGAGATTTGGGCTTTGTTTAAACCTCGACGGGCTGGGCCGCGGGGG GGGGGGGGGCCCCACAACCAAACCGGGGAAGAAA

>'990820A-051.scf came from CONTIG 63 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-051.scf(54>507)

GTTTCGGGGGCCAAGCGGGCTGTTTACTTATGCCGGAAAAGGGAAGTTTAACATCCAGCC CAACAAAAAGGGCTCCACCAGAAGCGCGCGTGGCCAGGAACCTGGAATGATTGCCGAAG

CACAAGAATTACTCCATGCTGCAGCTGATCCGGGCCATTCTGAAAGACCCACAAGATCCC ACCAGTGCTTTTGGTGGTTTGGCAACCAGACTGAAAAGACATTATTTTACGAGAGGACTTG GGGGACTGCAGGCCCGCCCCCCGCCGΠTATGTTTGGTTTACCTGGTAACCCCCAAAAGCC CCGGGGACGGAACCCGGTTCCCTGGCCCTCCTGTTTTTCTGGGCGGGGGTGCAGGGGGGT GCCCGTGACTTTGGGTGGGGACTGGGGGTTGAGGGGCAGCGGCACCTCCCTGCCCCCGCC

CCCGGCCCAGGTTGAGGGGGGTTCTTCCCGCCC

>'990820A-092.scf came from CONTIG 64 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-092.scf(61>496) GCACGAGGCTTCTTTCATGGATTGTATATTGTTTTCCTTTATGGCTGATCTCACACTAAGCA

TGCTTCCCTCCCCACCCAAAAGCTATTTCTTAAAATCGGATGTTTTAAAAGAAAAAAAAAA ACCCTCAGATTCTCAACAGGAAACAGTAAACTGGTGTGGCAGTAGTTCAGAAATCACAAA AGATACAAATGTAAACAAATCACTATGCAAAAGATAAAAAAGGAACAAAAGGAACAAAT CTATGGACAGAAGTAAATGCTAAGAGACCGGAATCATTTTGTTTTCACCACAAATTGCAA GAAAAGAAGAACAAGCTCGACGGAAACGAACAAAGAAAAGATAAAGGCCCGACCAGGA

TAATTAAAAAGAACTGGAGGGGAAGAGGGAAGGGGGGTCCGGGGTACGTGGACCTATCA GGGGCGGGCACAGGAGC

>'990820A-093.scf came from CONTIG 65 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-093.scf(55>471)

CGTTGCCGTCGCCATGACCCGCGGTAACCAGCGCGAGCTCGCCCGCCAGAAGAATATGAA AAAGCAGACGACTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGC AAGCAGAGGTAGCCCCAGGGAGGGGAGGGGAGGCTGGGGTGAGACCTCGGTCTGGTTTC TGAGTGCCCCCGGGTCTGACCTTAAGGGCAAGGGCGGGAGTTCACATTCAAATGCAGAAG AGGGTAGGACAGCCCGTACTTTGGGCCTCTTGCTGCCATTTGCCCTCCTTCCCCCAACCTTT

CCTGGGGGGGGGGGGGGGATTGGGACAAAACCCTGGCCGGGTGGCCGACTGGACCCTGG CAAAGCAAAGAAACGATGCTTGGGCCACTTTTTCCTGGTTCCGGGGGAACACACCAT

>'990820A-084.scf came from CONTIG 66 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-084.scf(58>374)

AACACTTTGAAAGAATTTGACCAATAATGTATGTTTGGCTTGTGCTTTAGTTTTGTAAGGC ATACTTTTTTGCTTGAATTTCTGTGTCCAGGAGAGTTTGGATGTTTAATGGTTCTTGAGCTA ATTTTATAATATATTTAATATATTACCAGTTGAGATATATAAAATTGGACATATTGAAATA AAAACCAGGGGCTAAGGAGGGGGAAAGACGGGGTACAGGGAGACCGGAGGGCGGTACC CATATGTGTAAAGGCATGACGAACAACCACCCATTTACCCTCCTGGGGTTCGGTGGAGAA

AAAAAAAGAAAACTG

>'990820A-087.scf came from CONTIG 67 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-087.scf(54>521) GCTGACTATTCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATTTGGTGCTTG GGCCGGGATAGGAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGG AACTCTGCTCGGAGACGACCAAATCTACAACGTAGGTGGAACCGCACACGCATTTGTAAT AATCTTCTTCATAGTAATACCAAGCATAATTGAAGATTGGGGAACTGACTTGTTCCCCTAA TATTTGGTGCTCCCGATTAGCATTTCCCGAAATAAAATTTAAGTTTTGGACTCCTCCTTCTT

ATTCCTCCTATCCCTGGATTCTTTTTGGGGAGGGGGCGGGAAAGGGGACCGGGGCCCCCC TTTGAGGCACCTAGCCTGGCGGGGTTTGTGTTTAACTTTTTTTTTTATTT^ TTGGGGCCTTAATTTTTAAAATTTTAATTAAACCCGGAGGG >'990820A-044.scf came from CONTIG 68 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-044.scf(54>605)

GAGACATTCCTCCACCTTAAGGAGGGGGAGCGGGGGCTTCCATTTCCTCCTTCCTCCTCCC TTCCTCCTCGGAGCTCCCCACAGCGCTCCCCGGGCCCCAGGCACGCCACCACATGGAAGG AAAGGCCGTTGAGGCATTGTTGTTCCGAGGGATTTTTGGGCGGGGTTCCATGCGGGCGCC CCACTCGGGAGCCCCCCTGGGCCTTTTCCAGCCACTCCCCACGGGCCCGGGGCTGCGGGG

GGGCCGGGCCAACATACAAGAACCCGGGGAGGACGCCCTATGAGTGTTGCTGTGGGACG GGAGCCGACTTCTGACCTGGGGGACATCAACGGGCACCACCTCCCACCAACCACATGGGG GGGGGGGGCCTGGGAAGGCTTGGAGGCGGGGGGGGCCGGCATGAACACCCTGGGTCAAA GGGCCGGTGGCGGGGGCGGGGCCCCATTTGGGACCCCGGCCGCGGGGGGAGGGAGGCCC CCCTCCGGCCCGGGGCGGCCCCAGGGGAGGGGGGAGAATTTGGAGGGGAGAGAATGAGC

CGGCTGCCCACCCCA

>'990820A-026.scf came from CONTIG 69 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-026.scf(60>583) GGACGAGGGGTACATCTACGAGGATCCAGCTGTCGGGCCATCACGGGGCTCCAGCAGGGC

CCGGGCTGGCTCTGGGGGCGCAGCATCGTGCCAGAGGGAAGGCACAACGCACCAGGCAC TTCAGTGCGCAAAGTCGGGAACCCTCCAACCAAAACCAGATAACTACGGTTCAAGATGGG CGACCTTGGATTGGGGGGTTCACCTTCGGTCCTCCAAAGTGGGGAAAAAAGACAAGACAA AGGTCGGTGTCCCCCCACCATCTTCTTTCCACTGTGGACCCCTGGGGGAAGGGAGGGGTTC CCCGGGTTCCAGCCACGAGACTGGCCGACTGCCAGTACCTTTTCTCCGGCCCCACCTGTGC

CGGGGGGCCCGCTGGGGGGGGCTTTGACGGGGGATGGGAGGGGTGGACCCCAGGAGCCA TAGGCTCCAGAGGGCACCGGCGGCGGGCAGGGCTCACCCGCGCTGGGGCCCCACCGCCGC CGGCCCCCCGCGCGGCAAAAGGGGCCGGGGAGGGAGGAGCGGTT >'990820A-075.scf came from CONTIG 70 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-075.scf(53>527)

TTTTTGTCTATTTTGTTCGTTGAAGTATCCCAAGCACCTAAAATAATGTACACAGCAGGTG GGTGTATTGAATAAGGGTAATAAATATTTATGAGATACCCAGTATGTATTGGGACAAATA TGAGCATTTAGTTGTGGCATGGAGAATGAGAATGACCTTTGGCAAGGTCAAAGAGAGTGG AAGAAGCAGAGTTTCTCACTTCAGAATTTTAAAAATTTACTCAAGGGGAAGCGGGAGGGA

AGAAGCCACCGAGGAGGCCTCTTGTAACTGCCTTGATATCGCCAAAGCACAGAAAAAAAT TTGGGGGTTTGCCTGCTCCCCTTATTGTGTTGGCCTAGACTTTATATATCATATGGAACCTA TTCAGCAACAACATTTTAGCTGGCTGATAAGAGACCTGAGGAGCGAGGTACTAACCAAAA CGAGCCGGGGGCCGCAAAAAATCTGGATAAGAAAAGGCAACACGAACAGTTC

>'990820A-074.scf came from CONTIG 71 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-074.scf(60>390)

GCACGAGGCTTTATTTTTGATATTTTGTATGAGCTTTTTATAAGTTTTGGAΓΓ^ TATCTGTCATACTGTGTGCAAATGTTCTCCCATTCAGTAGGTTATCTTTTCATTTTGTTGAT AGTTTGCTTTACTGAGAAAAAGAGATAATTAGGACCCATTTATTGATTTTATGCTTTTATΠ

CTTTTGCCTCAGGAGACAGATCCAGAAGAATATTGGTGGAATAGAGGGAAAGAGGGGTTT GCTTGGCTTTTTTTTAGAGGTTTATTGCTTAAAACTCGCATTAAGTCTCTATΠ GTTATTTTGCTTAGAATGAGAAA >'990820A-082.scf came from CONTIG 72 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-082.scf(60>513)

GCACGAGGCAGGTTTACAACCTGGTACTGACTACAAGATCCACTTGTACACCTTGAATGA CAATGCCCGGAGCTCCCCTGTGGTCATCGATGCCTCCACTGCCATTGATGCACCATCCAAC CTGCGTTTCCTGGCCACCACACCCAACTCCCTGCTGGTATCATGGCAGCCACCCCGGCCAG GATTACTGTTTACATCATCAAAGACCAGAAGCCTGGGTCCCCTCTAGAGAAGGGCCCCTC GCCCCCGCCTGGGGNCAAAGAAGCTTATATAATGGCCGGAAACAGAAACAAAAAACAAC CAAGCCATGCCCTAAAAACAACGAAAAGGAGCCTTGATGGAGGAAAAAGAAAAGAGCCC CAGCGGGACCCTCCACCCAACTTATGGCAAAATTGGTGGTCCTCCAAGAAAAAACCCTTT TACCAACCGGTTGAACGAAAGTTTAATTCCGGCT

>'990820A-076.scf came from CONTIG 73 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-076.scf(54>517)

TTTGTATAGAGCTGATGTGTGGGCTTTTAGAAACATAAATAAATAATAAAAGATCAAAAA GCAGGAGGCACATGACTATACTGGAAAATATAAAAGCCACATCTGTTTCCATAGTTGCCT

TTTGACAGCGATTGGCAAAGAACCATTGAATGTATTCTCACAGTCTTTGCTTATGTCATGG AACCTTTGTCCCTAACTCTCCTTTCCTGAGGGTATCGGGGCAGAAGGGTTGAATTATGAAA TTGGGGTCTGTAAGGATTTGTTCAGCTTGAGTTGTTGCTCTTTAGTTGGTTTCCTGTGCTTT CATGGGACGGTGAGCTCTGTTAGAAGATTTCAAGCCTCTAACCACCTATTATGGTGGCAGC GAGGAGCGCTGGACTGCGCAGACCAGAGGCCGTGCTTGGTGCTACACTTGGTCATATCCT

AATTAATGGCCTCATGGGACGTTTATTTATTAATGTGTT

>'990820A-080.scf came from CONTIG 74 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-080.scf (54>517) CACAGCCTCCTTTCAGCTGTTTCTGTCTCAAAGTCTTTGCTAAAACATTTCTCTCTGCTACG

ATCCTCTCCCATTCTGCCCCCAACTTCATCTCATTGTTGCTGTCATGTATTAGTCCAAATGT TACTTCCCAAGGAAAGCTTTCTGACAGGACCAAAATAAGTCTGCATTTCATATGCTTCAGA GCCACCTGAACTCTTAAAGCTATTCACTATTTTATGTATTTAGGTAATTTAGTGATTGAGGT GTGTCTCTCTTATGGACTTTAAAGTCTAGAGAACATAAGCCCTGGCTCTTAGCCTCTCTGA TCTCAGAGCCCAGACAAAGATGAAGAAGAACCACTCATCCGGCATCAGAAAGGGAAATT

CCCCAGCTCCAGCCCAGATGGGCTTCTGCCAGCAGGGCCGGGATCCGGGTAACCCGGCCG ATAGGCGGGAATTAGCCGAGCTTTGGGGGAGCGGCTT>^,990820A-078.scf came from CONTIG 75 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-078.scf (60>424) GCACGAGGGTGCTCCCGGCAGCCGCGGTCCTCTCAGTGCATGGGGCGCCGCTCTGGTTCC CGCCCTTGCTGGTGCGGGAGGGGGGTGCTGGCGCGGGAGCGCTTTTTCNGTTTTGGCTGGC

TGGCGGGGACTTCGGGGAAAGGGAGGGGGAATGCGGGAGCAGAGGGAAGGCACCGCCCC CCCCATGGGGAGGGCTGGTGGCCTCCGGGGCGGGAGATTCAGGGGCCGGGGGGCCCGCG GCGGGACCGGAGCCCCCGGGACCCTTTCTGCCCAAACCATGAGCATTCTTCAAAGAAAGC AATGGGTTGTTTGGTTTTTTGAGACCCAAAGGCCCCAGGGACCCTGCCCGGGAGGCAGCA TGGGGG

>'990820A-077.scf came from CONTIG 76 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-077.scf(54>528)

TAGTAACTATTGGCATTAACCAACCTTACCTAGCTTTCCTCCACATCTGTACCCACGCCTTT TTCAAAGCTATACTATTCATATGCTCCGGTTCCATTATTCACAGCCTAAACGACGAACAAG

ATATTCGAAAAATAGGAGGCCTATTTAAAGCCATGCCATTCACCACAACAGCCCTCATTGT TGGCAGTCTCGCACTAACAGGAATACCCTTCCTCACAGGATTCTACTCCAAAGACCTAATC ATCGAAGCCGGCAACACGTCTTATACCACGCCTGAGCCCTTCTTATAACATTATTGCCACT CTTTTAAGGTATTTACGCACCGTATTATTTTTTGGACTTCTGGACACCCGATTCCTACCTAG TAAATTAAGAAACACCCCTCTGATCAACCTTCAACGCTACTATTGGAGCCGTTCCAGATTC

ATATTCCACATATCCTCACACAATCCCAATACATGCCTATCCTAAC

>'990820A-081.scf came from CONTIG 77 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-081.scf(54>539) GGTCTGCGGCTCCAAGTATCTTGGGGCGGGGCGAGGAGTGCCCTCGACCACGTGTGGATC

TGCTCGTGCTCTTTCCCGNCCATTGGGCCTCCTGTGTGACGTGGGTTGACATGGGGCACAC CTGTGGGGCCTGGGGTGCTGACCTCTGGCTACCCCGCACCTGACCAACCAGATGTGGGGG AAGGAATTTAGGGCTGTTTCTCTAGCCCCCACGGAGCCACCAGNGAGGGGGGTCCTGCCC CAGACCTCTGGACCAAGATTATACAGGGGAAATGAAAGAGCCCGAGCACTCTGCCCAGA ACCTTGTCACAAGAATGCCAAAACGCGCATCGGCCACGCAGGCAACAGGCAGCCTGGGA

ACCAAGCTGGAAACATTCTTGCCCTGGGTCTGAGTGGACCCATGNAGCATCTGGCTATTG AAGAAGAAAAAAAAAGGGGCGCAGGCCCTTGCTTTGAAAGCCACCCTTTACTTTAAAGGC TAGGTTC >'990820A-090.scf came from CONTIG 78 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-090.scf(60>330)

GGACGAGGTGAGAGCCCTGCAGGTGCGGACCGGGAAGTTCAGGCCCAGCGATGAGCACC ACCCGGGAAGTCAAGGCTGATGGATACGTGGACAACCTCGCAGAGGCCGNGGACCTGCT GCTGCAGCACGCGGACAAGTGACGGGCCTTCTGGGAGGGCCCCGCCTCCTGCCACCCTGC

CCCGTGCCCCAACCACCCAGGGTGCTGCCCTCGGCCCCTGGATAAGAAGGGAGAAGGGGG CAGCCAGGCTGGTTTGGGCCCCCGGGCCACCCA

>'990820A-088.scf came from CONTIG 79 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-088.scf(54>514)

CTCGCGGCGGCAAGATGGCCGTGCAAATTTCCAAAAAGAGGAAGTTTGTCGCTGATGGAC ATCTTCAAAGCTGGAACTGTAACGAGTTTCTCACTCGGGAGCTGGCTGAAGATGGGTACT CTGGAGTTGAGGTCCGAGTTACACCAACCAGGACAGAAATCATTATCTTGGCCACCAGGA CACAGAAAGGACTTGGGGAGAAGGGCCGGGGGATCCCGGGATTGACTGCTGTGGTTCAA AGAGATTTGCCTCCCCTGAAGCAGGGTAGAGCTTTATGCCGAAAAGGAAGCCCCAGAGGC

CTGGGGCCCTTGGCCAGCCGGGTTCCGCGTTCCAACTCCAGGGGCCCGCGGGCGGGGCCC GCTTGGGGCCGGGGCCTAGGGGAGGGGCCAAGCGGGAGGCGGGGGCGGAAAACCGGGC AAGGCCAACCCGAATGGGGGGCCCGAACCCCGGGGCCCCGTACC >'990820A-085.scf came from CONTIG 80 at offset

0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-085.scf(54>520)

GTTGAGAGGAGCGTGGCCTTCTCCTCTCCCGCCATGGCGTGTGCTCGTCCACTGATATCAG TGTACTCCGAAAGGGGGAGTCCTCTGGCAAAAATGTCACTTTGCCTGCTGTGTTCAAGGCT CCCATTCGACCCGATATTGTTAACTTTGTTCACACCAACTTGCGCAAAAACAACAGACAGC CCCTAGCTGTCAGTGAATAAGCAGGCCATCAAACCAGTGCTGAGTCTTGGGGGACCGGCG

AGCTGTGGCTCGATTCCCAGGGTTCGGGGGGGGGGGACCACCGTCCCGCCCGGGGGCTTT GGAAACAGGGGGGGGGGCCGATGTTGGGCCACTAAACCTGCGCGGTGCCCCGAAAGGAA ACCACCAAACCAACCCCTCCGCTTCCTGCTGCCCACCCTCCCCCCCGGCAGGCAAAGGAA AGAAAAAGAAAACCCGACCCCTTGGGGGGGGAAAAGGAGGCCCCC

>'990820A-067.scf came from CONTIG 81 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-067.scf(54>455)

GTCAAATTGTGTCCTCCATCACTGTTTCCCTGAGGTTTGATGGTGCCCTGAATGTGGATCT GACAGAGTTCCAGACCAACCTGGTGCCCTATCCCCGCATCCACTTCCCTCTGGCCACATAC GCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCA

ATGCTTGCTTTGAGCCAGCCAACCAGATGGGGAAATGTGACCCTCGCCATGGGAAATACA TGGCCTGCTGCCTGTTGGACCGGGGGATGGGGTTCCCAAAGATGGCAATGCTGCCATTGC CACCATCAAGACCACCCACCATCCAATTTGGGGACCGGGCCCACGGCTTAAGGGTGGATT ACTCCACCTCCCCTGGGACCGGGGGGAACGGCAAGGACA

>'990820A-068.scf came from CONTIG 82 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-068.scf(58>322)

AGTGGCGAGGTGCGTCCTTGTGTGCCTGGCCTCTTGCTGGTCCTGCCTTCACGGGGTGTGT CGCCAGTAGACCGCGGGAACAAGGCTCGGTCCCGCTAGCCACCGCCGCCTACTCTTGGTC TTTACAGATCACCGGCCTGGACTTCCGTGGGTGCGCAGAGGCTGCCATGTCACCGGGTTTA

GGATCACCCCTCACCAGCCGCATCGCGATGAGCCTGGAGAAGGGGGGGTGCTGACGCTGA CCAGAGGCGCGAAAGATAAAGAG

>'990820A-095.scf came from CONTIG 83 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-095.scf(l>528)

TGTTCTCTCATCCGGGTGTGTGTCGGGGCTGCTTCTAGTTTCGTTGTTGGCATCCCGCCTCG GTTTCGTGCTACTGATGAGGGCGTGTGACGCCACCTGTGTCATCCACTGGCGTCGTGTTCG GCTCCTTTGTGCCCTACTTGCTTTCTCTGCCCGGACTGGGTGGCGGGTCCCCCTGGGTGGC CTGGAATACGTGCTTTTTCTTTTTGGGGTTTGCACTCTCGGCTCTAACACGCTTTGCAACTA TTTCTCTTCTCATTCCTATAGTCCTTCACTCATGGCTTGGTTTCTTTTGCGATGTCCAACAGC

CAACCCCGCCCCCACGTCCCCCTCCACTCTCCCTCCTTCCACACATAATATAATAAACATT GTAACTACAAATTGTAAGTGAAAGTCTCACTGTTCTATTAATGTTGCGTGCTTTTCTCTAAC CCTC1TATCCTTGCTTGTCTCATTTTGGCTTCTCTTTATTCTTCCTCAATCAATTCACATAAA TATCTTATTTATGTTGTTTGTTCTCTTGCGTTC >'990820A-091.scf came from CONTIG 84 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-091.scf(56>478)

GCTCTGAGTGGTTTCCTGTTGCCAGGGCTCTAAGACCCCTCACATTCCTGCAGACCTCCAA ACTGCCCGGGGCTTGCCTGCTGCCTGCCTGCCTGCCACTGAGGGTTCCCAGCACCATGAGG

GCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAACAGGAAG CCTTGCCTGATGAGACAGAAAGGGAGGAAGAAACCGGGGGCGAGGGGGCCGGGGACCCG GGGGAGCCCACCCCGCCCGGGGGAAGTAGGGAAATCGGGGGTGGGGGCCGGGAAACCGG GAGGAGGGGGGGGCCGGACCCCCGCCAACCACAAGCAAAACGGGAGGGGGGGAAGGGA GAAACAAACCCCTGGGGGGCCCGCCCCCCCCTGCCTGCCCCTGGGGAGTGGAAGGGGCAC

ACAA

>'990820A-083.scf came from CONTIG 85 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-083.scf(58>513) GGGCACGAGGCCCAGCAGGGCCCTAGCCTTGCCCTGCCGTCCTCCCATCACTCTAGCCCAC

CTGTATCAAGGGCCGGGGAGGGGCCGCCCCTGCTGCCCACCCCAGCATGAGGTTCTGAGC CACACCCTCCCCACAGACAGCCGCTCCGACCGCTGGTCCCAGATGCCAGCAAGCAGGGGG TGAAGGAGGACACAGAGGACGGGCGGCCGAGGCCCGGGACAGCCCAGCCCCGGTCCTTT CGCATCCCTGCCCACCTCAAAGCACCGGGGTTATGCAAGACCCGGATGAGAGGCACCGAG AAACAGCCCGGGGCCCAGGACGAAGCCCCACCCCAACCCAACAAACCAGAACCCGGGCT

GGGGAAAAATGAATTGGAAAGGGGGAAACACAAGAAGGGGGGGGGCCCCCCAGGGCCC GGCCTCCCCCGGCCGGGGGGGCCGGGACCCATGGCCCTT

>'990820A-089.scf came from CONTIG 86 at offset 0;"E:\SEQUENCE\export\EG_DB\990820a\990820A-089.scf(46>647)

CGCTTGCAGGGCAGGCAGCGGGAGCGCACGGGAATGTTTGTGCCTGCCGTTGGCTGCGTT ACCTTCAGGGCGGCCGGGCGCGAGAACCCTGGACCCATGGGAAACCCTCACAGGCTTCCG TTGGGGCCCCTTTTGCAGCTTGGCGCTTTTTTGGCCCCTAACGCTTTTCAAACGGGAGGGT TACGGTTATTGGGCAAATTTGGGTTGGGAGAAAGATTTTTTTTAATTTGGTTGCCTTTCTGA ACAACTTTGAATAAAGTGGAAGGGGGTTTCTCAAAATTCAAACCACGGGAACAAGGCCCC

CAAAATGTTTCCAAAATTΓAAACAACCAAAAACAATGGATTTGGGTGGTAGGGGGGTTTT TATGGGGGAATTTGGCTTTCCCCTTGCCCAAAAATTTTTTGAAAGCAAGAACTAAAAAAGT GCCCAGCCTTTCCACACATAAGGGCCTGACCCCCGGGGGCATTTGGTGGGTTGTTTGCCCC AATTCCTGGCCTCCTGGCCTTTTCCTTTTTTTTGTTCCAATATTTGGGGGGGTTTGGGATAA GGAGGGGCCGGTTTCCCGTTTGCCCCGTGGGCCCCCCCAAAAAATTTAGACTTTT

>'990913a2-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-001.scf(57>62) TTAGGG .

>'990913a2-002.scf came from CONTIG 2 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-002.scf(13>49)

GTCTGAATAGGGATCCCCGGCTGCTTTTTTNGTTTGA >'990913a2-004.scf came from CONTIG 3 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-004.scf(51>218)

CTTTTTCGGCTGGAGCGGGGCCCGTGCGGGATCGTGGTGCTTGGGGGTGAGGGGCGAGAG GGTGCGGGGGTGGGTCGGCGGATTGGCTGGGAGGGAGGATGCCCGACGAACGGTGGCCG CTTGCGGGGGCCCATTTTATGTGGTAAGGGGGGTAGAAAGGGATGGGCG

>'990913a2-005.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-005.scf(51>356)

CCAAAATCTACAGCCGCTCACTGTTACCTGTCCTGCGTTCAGGACGTGTTAAGGCCGTTGC ACATATTACTGGTGGAGGATTACTGGAAAACATCCCCAGAGTCCTCCCTCAGAAATTGGG GGTGAATTTAGATGCCCAGACCTGGAGGGTCCCCAGGATCTTCTCATGGTTACAGCAGGA

AGGCCACCTCTCTGAAGAGGAGATGGCCAGAACATTTAACTGTGGGATTGGGGCTGCCCT CGGGGTATCAGAGGACCCGGNGAAGCAGACTCTGCGGATATTGAGCAGCACCAGAAGAA GCCGCG >'990913a2-007.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-007.scf(57>326)

GCACGAGGCACGTGTGATTGTGTCTCCACACATCCGTGCATGTTCCCTGCCTTCCCCTCCG CTCCCTGCCCGCCTGCCCTCTGGCCCTTACCATGGGCGGGCCCCTGCAGTGTGGTCTGTTG CCCAGGAGGCGAGCGCAGGGACTGAGCTAGAGGATACAGGAGCCTGGGCTCCCAAAATG

CCAAAAACTCACACATATTCTCGCTGAAGGGCCGTAGCCTGCCTCACCACCATTTCACACC CTCACCTGGGACCTGGGCTCTTTTTTTT

>'990913a2-008.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-008.scf(49>556)

TGTTAGCTTAAAAGATGGCGGGTTCCGCTGTTTGCCGGGCAGCTGGCGCCGGGAGCGAGT GCTGCTACGCACCCGCCGCTCGCCGGCCCTGCTGAGTCGGCTGACTGGGGGGCACCGCCA CCTACGCCCAGGCTCTCCACAGCGAGCCAGAGACGCAAGTCAGCCAGCTGGACAACGGGC TGCGAGTGGCCTCGGAGCAGTCTTCCCAGCCTACCTGCACGGTGGGGGTATGGATTGATG CTGGCAGCCGNTACGAGAGTGAGAAGAACAAGGGGGCTGCTACTTTGGGAGCATCTGCTT

TCAAGGAACAAACATCGCCTGGCATGCTTGGAGAGGAGGTGAGAGCATGGGGCCATCTAT GCCTACACACCGGAGCCACGCTTATAATAAGAGTATCAAGACTGCAAAGTGAGAGTCTGC CGCACTGCAGATCANCTCAGACTCCAATGAGAGAGCGGAGGATCTGAGAGTGAGAATAC CATCTGCGACGTCTTATACTGTTGCCGCT

>'990913a2-009.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-009.scf (51>340)

TTGTTCCAAGATTATTTCAGAGCAAATCTGAAGGAGGACCACTGACAAGCCCAAAATATT TAATATACCTGATGAAATGGCCAATCAATATATGGAGAGGGCCATCAATGTAACCTCCCT CAAAATTAAACCACGTTAGCTATCACCTACACATTAGCTATCACCTATGTCACACTGTACT

TAAGCTTACTCCCAAGTGGAAGCTATTTTTATATTTTAGANTCAGTCGCTCAGTCATGTGT GACTCTGCGACCCCAGGACTGCAGNACTACAGGCTTTCCTGTCCATCA

>'990913a2-010.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-0 lO.scf (47>342)

GGTTTTTTCACCACATCAATGGGGTAACGGTTTTTCCCAGCCACACGCTGCATGACAGGCC ACCGGCCATTTTTCAGTTGCTGAATAAACGCGCCGGGAATACGACGGCTACCCACCACAA GCACGCTGCCGCCACCTTTCAGGGATGAACGCTGCCCCTTTTTACGACGCCTGCGGCGCGA AAGGACAACCCGCGCATTACCCAGCTTGATTACGGGCAAATCCCCCCGGTTAACTTTGATT CTGGCCTGCGGATTTTTGACCGTGGGCCTTTTCAGCCTGGCCCTTTCTTTACC

>'990913a2-011.scf came from CONTIG 9 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-011.scf(62>109)

AAGCAACGGCACGGCCAAGGGCATCAGCTGCCACTTCTGGGGACGTGG

>'990913a2-014.scf came from CONTIG 10 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-014.scf(52>227)

TGGCACGAGGCAGAGGCTCCAGGAGGCCCTGCAGGTGGAGGTGAAAGCTGGGAGGACGA

GGAGGCCGTGCGCCTCGCCCAGACCAGACTGGTAGAGGAGGAGGAGGAGAAGCTGAAGC AGCTGTTGCAGCTGAAGGAAGGAACAGAGAGGCGCTTACATCGAAACGGGCACAGGCA

>'990913a2-015.scf came from CONTIG 11 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-015.scf(56>572)

GCACGAGGCACAAAATAGCCCTTCTCCCTATGGAGAACCAAGCAGTTTCCATAACAGAGC CACTTTGCTGGATGTATTCTCGAAGGACTCAAGCAAGCGTACACTAAGACTTTAAACTATG

CTAAGTTGACTGACATATAACAGGGAGAGAAGGAAACTCCTGATAAACCTCTAGTATAGA CTACGGGAGGCTCTCTGCAAGTTTACTGACATTGATTCTAAAAGGGCAGACAGAGAAATT TTCTTAAAAGATAGATTTCTCACTCAGACAGCTCCAAATATCTGCCATAAGATACAAAACA GGCATTGGACCAATCAGACTTTAGAAAACTGTGCAGCTGGTCAGTGGTGTATATTGTAGA GATATGAGAGAAAATAGANGCATAAAGAACCAGCAAGACTGAGCCCACTGGCTTAGATT

GCTTGAACAACTGGAAAAGCCAGGNAACGGNGAAAGGATGAGCTGTTTTGGGAAGAGGA TGTAGTGGAGCTTAGCTCTACTACCCGCCCTGTAGCT >'990913a2-017.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-017.scf(49>312)

TATTTGGCACGAGGGTCCCTCATTCCTACTACTCCTCGCATTCTCTATATTTGAAGGTGGG GGAGGGACAAGGTGGACCGCGGTCCCTCCCTTTGCAAGGGAAACTAAGCCATGCCGGGG GCTTGAGTAGATCTATCCATTTTCTCTT^

CATCAACTTCATTTCAACAATTATCAACATAAAGCCCGCCGCCATGGGACAACACCCAAC CCCCTGTTCGGTGATCCGCGTG

>'990913a2-016.scf came from CONTIG 12 at offset 6;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-016.scf(55>576)

GCACGAGGCTCCCTCATTCCTACTACTCCTCGCATCCTCTATAGTTGAAGCTGGGGACAGG AACAGGCTGAACCGCGTTCCCTCCCTTAGCAGGCAACCTAGCCCATGCAGGAGCTTCAGT AGATCTAACCATTTTCTCTTTACACTTAGCAGGAGTTTCCTCAATTNTAGGAGCCATCAAC TTCATTACAACAATTATCAACATAAAGCCCCCCGCAATGTCACACTACCAAACCCCTCTGT TCGTATGATTCCGTCATAATTACCNGCCGCACTACTACTACTCTCGCTCCCTGTNTTAGCA

GCCGGCGTCACAATGCTATTACAGACCGGAACCCTAATACACCTTCTCGACCGGCAGAGG NAGAGACCTTTTTATTTAACACTATCTGTTTCTTGGCACCGCAGTCTTATTTTATCTACTGN GTGGGATAATTTCTTNGTGACCACTATAGAAAAAAGAACATCGATTATGGGATGTGGGCT TATGTAATCGTTTCTAGTTTGTTGACCACCTTTATA

>'990913a2-019.scf came from CONTIG 13 at offset 0;Ε:\SEQUENCE\export\EG_DB\990913a2\990913a2-019.scf (48>315)

CAAAATCGAGAATAATGAGGGAGTTCGGAGGTTTGACGAGATCCTGGAAGCCAGTGATG GGATCATGGTGGGGTCGTGGTGGATCTGGGCATTGAGATACCCTGCAGAGAAGGTCTTCC TTGCCCCAGAGATGATGATTGGTCGGNGCAACCGAGCTGGGAAGCCCGTCATCTGTGCCA

CACAAATGCTGGAGAGATGATCAAGAAGCCTCGCCCTACCCGGCGGAGGGAGNNGACGG GCCATGCCGGCTTGATGGACCGACTGCTCA

>'990913a2-020.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-020.scf(48>580)

CGAGTGGGAGCCCCAGGGCCGCGGTCTGGAAGCGGAACTTGTCGGATTGTTTTAAGAAAA TGGCAGACAAGCCCGACTTGGGGNGAAATCAACAGCTTCGATAAGGGCCAAGCTGAAGA AGACTGAGACGCAAGAGAAGAACACCCTGCCGACCAAAGAGACCATTGAGCAGGAGAAG CAAGCAAAGTGAGATTTCCCGCGAACCTGGGGATTCTCCACCGCATCATCTTGGAGACCC TAGCCGNGGTGTGGAGGGAGAGCCACCTGCANGATGTACACGAGCGACAGCTGGACTGT

GAACCCGGGCNCTCGTGCCGGCGCACCGGCCGCGGGGGTTGATGGGACCTTCCATCGGAC TGCCAATTTTCCGGTTGGCTGGATATTATAAATATTTGTTGATAATAAAATAACACACCCG GGAAAAAAAAAAAAAAAATGGGGGGGCCGGCCCATTCGCCTTTGGGGGTTTTCATCACTG GCGGTTTCACGGGATGGGAACCCCGGTCCACTTATGCTTCCCCTCCCTTTCCCTT

>'990913a2-021.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-021.scf (45>59) TTTTTTTTTGTACGC >'990913a2-022.scf came from CONTIG 16 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-022.scf(53>59) GTGACGA

>'990913a2-025.scf came from CONTIG 17 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-025.scf(47>348)

TGTTTTTTCTTCCTTGTGCAGAGATGCTATCACCCACACATCTCCCCACCCTGCCACATGCA GCCTGGAATTCTCCTATGGTTTTCCAGTGGGTCTGTAGTCTGCCAGAGGAGCAGGGGGTGG CCTCAGACAGAAGCCATGAAGAAGATCCCCACACAAAGACTTTAAGATCCACAACGCTTA CTTGTTTTCATTTATTTTGATAGAGCCATACAAATCANTATTCCAAAGGATGGGGAACAGC GCAGCTAAGCAGACTTTATTTCCCAGCCTATCATATGCTCGTTGNTTCTGCCTTAGTA

>'990913a2-026.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-026.scf(43>597) CGAGAACCTGCAGGACTTAGTGGGGAAGCCGGTGTTCACAGTGGAGCGCATGTATGACGT GACGCCGCCTGGCGTGGTCATGGGGCTGGCCTGGACGGAGCATGGGAAGACTCCACGCTG TTTGTTGAGACGTCCCTGAGACGGCCGAGGGACAGAGACAGNGACAAGGGGGACAAGGA TGGGAGCCTGGAGGGGACCGGCCAGCTGGGGGAGGGATGAAAGAGAGCGCCGCATATCC TACACTTCCCCAGGCCCTCCTGATGCAGCACGACTCCGCCAACAGTTCCTGTTGAACTCCC

CATCCACTGCACGTGCTGAAGGGCCACCCCAAGACGCCCGAGGGCCGCTGACATCTCTCN GNCCTCTCTCTGCTTTGACGGCAGGCNGAGAAACTGCTGACGCGAGGCTCTCCAGCAAAG TGCTGTGGCGGTTAGAGAGACACCGCCAACGGCGGGACCGCTCCCTCACTAGACAGAGAT CTTTACTGTTCTTTCCCAGCCCTGGGGCTGGGGCCTCCCGATTTTCTTCCTTCGGGAGGGCG GGCCGGGGGGGGCG

>'990913a2-028.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-028.scf(l>538)

ACGGGGGCGGCGTCTAACTAGNGGTCCCCCGGGCTGCAGGTATTCGGCACGAGGCTGTGC TGGACTGCATTTCCATGGAAGGGTGCATAGTCTGCTCTTTTTGTCTGGATTCCCTCATCAA

GCTGGTCAGAGTCACGAACGTCGCCCTGTGTGGGTGTGGGCCGGACCCTGTCCTTCCCGTC ACTGTGTGCCTGTCCCCGCCCACTGCCCCAGGTCCTGGAGCTTCTTAGAAGTCTGAATGCC TGGNGGCAGAGCCTTCCGCTGTCTTCTTCAAGATCATCCGCGNGTCCTCACCTTTGTTTTTT TTTGTCAATGTTCAAATCATACATCTATTTCTCCCGAGTGTGTGTGTGGTATTTTATGCNTT ' GΠTATGTTAGATATTACATATGGGAAGAATGACTCTTGCATATGGAAGTAAAGACATAA TAAAAAATATACCTGGCAATTTGTGCTACTACAACAAAGGCTGTCGCTATTTTATGTTATT TAAAAAAAAACATATCAGCATTCACAAAATCTTATATTAAAATAAAAACT

>'990913a2-029.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-029.scf(41>144)

TGGTTTTTATTGTAAACAATGCATTCATCGACCTTCCAGCCCCATCAAACATTTCATAATG ATGAAATTTCGGTTCCCTCCTGGGAATCTGCCTAATCCTACAA

>'990913a2-031.scf came from CONTIG 21 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-031.scf(53>58) CAAAGA

>'990913a2-032.scf came from CONTIG 22 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-032.scf(52>59) TTGGACGA

>'990913a2-034.scf came from CONTIG 23 at offset

0;Ε:\SEQUENCE\export\EG_DB\990913a2\990913a2-034.scf(46>624)

GTACGAGGCTAGGCCGTGCAGCTGCTGCCACCGCCGTCTGTCTGCCTGCCCTCCCGTCGGT CCACCCGCAGCATGAGCGGCCTGCGCGTCTACAGCACGTGGGTCACCGGCTCCCGCGAAA

TCAAGTACCAGCAGAGTGAGGTGACCCGCATCCTGGATGGGAAGCGCATCCAGTACCAGC TAGTGGACATCTCCCAAGACAACGCCCTGCGGGACGAGATGCGAGCCTTGGCCGGGCACC CCAAGGCCACCCCACCCCAGATTGTCAACGGAGAGCAGTATTGTGGGGACTATGAGCTCT TCTGTGAGGCTGGGGACATACACACTGANGAGNTCCTGATACTGCCTGAGCAGCCAGACC CTGACTCGTCATACATTCCCTCCCACCATCACCCGGCTGAGGACCTGGACCACTCCTGTTT

TCTACTGACGGGGCTTCCCTCACCAGACCCTCTCTCCTACTTAGCCCTCTTTCATCACACAC ATCTCACCACGCTAAATGATTAGACAGCAAGGTGTGCTAGTGGCCTGGTGGCCTCTGCTGT GTGGCCTGTGTCATACAGTTTCAAGCGCATCGCG >'990913a2-035.scf came from CONTIG 24 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-035.scf(53>562)

GCACGAGGCCCCTTCAAGGCCAGAGTCACAGGTGACGGCCTCGTCAGCAACCACAGCCTC CATGAGACATCATCTGTGTTTGTGGACTCCCTGACCAAGACTGCCACCATCCCCCAGCACA GTGCCCCAGGCCCGGGTCCCACTGATGCCAGCAAGGGGCTGGCCAAAGGCGTGGGGCTGA GCAAGGCCTACATGGACCAGAAGAGCAGCTTCACGGTGGACTGCAGCAAAGCAGGCAAC

AACATGCTGCTGTGGGGCGTGCATGGGCCCCCGACGCCCTGTGAGAGATCACTGGGAACA CGTGGCAGCAGCTCTCAGAGTGCCTACTGCTCAGGACAGGGGGANACCGCTGTGGNCAGG GGGGGACAGCCATCCGGGCAGCCTCGAGCCTGGGCCTGGTGTGGCGCTCCATCACACTCC AGACAGAGGCCCTCGCTGCCCTGCACCACACACGCCCACCCGCAGCCTGCACCTCCTACC TGCCTCTGGTGGTACTGCTCANGGCAAGAG

>'990913a2-037.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-037.scf(54>628)

GCACGAGGACCTCTTCTGCCCCCCGTCCCCTGTGCCCACCACCTGCTGTCCTGGTGCAGCA TGTGTTACTTCTGGCTCCCATGCCCTAGATCTGCTGGTGGTAACCTTGGAAGAGCTGGCCA GGCCTGGAGGTTTCCTTCTCCATTTGTAGTGTTCCAGAGTGCCATGATTGCCACGCCCCAC CAGAGCTCCACTTGTCATGCTCGCGGCCCATCCACACACCTTTCTTGCCTCTTGCCTCCTGC AGGGGGGGGGGGGATGGGAGTGAGACAGCCCGGCCCCTCTTCCCCTCTCCTCCCACTGAG

CACCAGCTGCTGCTGCCAGNGAAGCTCATGACCGGGGCGGNCAGCTTCCCTCCACTGACG AATCATTATCTTAACTAATAAATCACTATTAAAGACCAACTAACTAATGATGAAGATGGC GAACATTTAACTCGTTTTAGGTTTTGTTTC^ TATAATTTACTGTGATGACAAGAATGCTGTTCTTGAGACATTTTGATTTGTTATTNGTTTTC TTTCTTTCCCTACATCTACCATATC

>'990913a2-038.scf came from CONTIG 26 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-038.scf(53>537)

GCACGAGGCAGCGGGCGAGCTGGGACCCGCGTGGCATCCTGCCTCCCTGCCCGCGAAGTG ACAGTTTACAAAATTATTTTCTGCAAAAAAGAAAAAAAAGTTACGCTAAAAAAAAAAGCC

AAAAATACCCACAAAACCACATATTCTATTATACAAAAAGTATTCTTTTCTCCACCCGCTT AAAAGGAAAAGAGGAAGAATTACCCCTTTGCACCGCAATGTTTTGTTTTGCTGGGACATA AGCAAACACCCCAGCCAATGTTATATCCATCCTTTTTTTCGTTTTTTTTTTTCCTTTCTT^ GCCCCTCTGCTGTNTCCATTCCCCATCTCCTGGCCCCTTGTGGGGAGTGGGAGGTGGGGCG GGGAAATCTGCCAAAGCCATGTGCTGTGTGTGCTGCCCCTGTCCTGAAATTTTTGTTTAAA

AATTTTGATTGTTGTTTTTAGAAAAAAAAAAAAAAACCCGATGAAGAAAGACCCTGACG

>'990913a2-040.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-040.scf(54>148) GCACGAGGGTTTGGGAGAGAGCCAGCTATTCTGGGGGGAAAATTTTGAGGGAAAACAAC

TATTAAATGGGGTGGATTTAGTTTTTTTTGTCCCTA

>'990913a2-041.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-041.scf(l>634) CGGGGGGGCCTTAAATATGGTCCCGGCTGCAGAAAATGAAGCTGAACAAAATCTTCATTG

CGGAGGTACTTGCCTCATCCGAGCGAGCCCGCCGACATGCTGAGCAAGAGAGAGACGAG CTGGCGGACGAGATTGCCAATAGCGCCCTCCGCAAGTCTGCACTTCCGGATGAGAAGCGG CGGCCTGGAGGGCTCGATCGCACAGCTAGAGGAGGAGGTGGGAGGGGAGCAGAGCAACA TGGAGCTGCTCAATGACCGCTTCCGCAAGACCACACTGCAAGGGGACACGCTTGACACTG AGCTGCGGCCGAGCGCAGCGCTGCCCCACAGAGCGTAATGCGCGCAGCAGCTGGAGGGG

AGAACAAAAGTTGAAGCCAGCTGAGGAGCGGGAGGGCGGCAGTCCAGTTATGGCACCTC TTTGTTTGAAGCAGATGGGGTGGAGGGAGTGTGCAGGAGCAGGAAGACCGGCCATAATAT CGGGTACGGAGAGTGTAGATTTTTGCGTGAGTGAAGCGCTGCGTCATTTAGAAAGGGAGC ATGCAGTGAAGTTAGGGGGTGGGAGGGGAGAGTCAGCCGCTTTGCCACCCGGGACGTGG CTGGCCCGGGCGCGGGCGCCGGAAGGGGGGGGCGTGTCT

>'990913a2-043.scf came from CONTIG 29 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-043.scf(l>368)

CGGGGGCTTAATATGTCCCGCTAGAATGACAGTCCTGTGATGATAGGTGTTGTTTATGTCC GGACTTGTCTGTGCTGATGTTITTTATTTGATCGGCAGGACAGAGGATTTTGGGGTAGTTC

AAGAAAACAAAAAGAAAGGAGGAAGAAAAGTGAGCTCAACGAGCCCGCGTCCTTTTAAG AAACATGTTTGCCTGACAGCTGGCCTGCCACGCAACAGATTCGCTTTCATAAGATTGCAAC AACAAAGTTTATGTACATTAAATAAATAAAAAATGAAAAAACAACAAAATTTGAGTTGTG TATAATAAAAGGAGAGAAAAATAATGGTGTTTAGTAATTTTGπ^ AATT

>'990913a2-044.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-044.scf(46>224) GCACGAGGCTCCCCCCGGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCTCCGGTCTCC TGCTAAGCCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTACCGGGACCC TCATTAGCCATGACGAGATGTTCTCCGACATCTACAAGATCCGGGAGGGGGCGGACG >'990913a2-065.scf came from CONTIG 30 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-065.scf^'(54>601)

GCACGAGGCCCCCCTCCCCCCGAGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCTCCG GGCTCCTGCTAAGCCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTACCG GGACCTCATTAGCCATGACGAGATGTTCTCCGACATCTACAAGATCCGGGAGGTCGCGGA CGGGCTGTGTCTGGGGGGGGAGGGGAAGATGGNCAGTAGGACAGAGGGTAACATCGATG

ACTCGCTCATTGGTGGGAAATGCCTCGCGCTGAGGCCCCGAGGCGAAGGTACCGAAGCAC AGTATCACTGGTGTCGATATGTCATGATCATCACTGCAGGTAACAGCTCACATAGAAGCT ACAGAATACATCAAGATACATGAGTATCATGGAACTGAGAACAAACAAAGATAAATCTTT GAAGGCTGAGACAATAGCCATCTGTATTCAAACTTATTTTTTGGAACATGATCAATGCTGG TGTTCGGCTCGGAGTGGACCTTTTATTTTTAGTGTTAATGNAAGTTAAGATGGTTCTGTAT

ACTGT

>'990913a2-045.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-045.scf(l>208) CGGGGGGGCGTTAGACTAGGGTCCCCGGCTGAGGAATTGGCACGAGCCCCCTCCCCCCTA

GGCCCGACACCCCGTCTCTGGTACAAGCAGACCAAGAGGCTCAAGCCATGGCAGACCAAA GCCGGGGGAAGAGATGCAAGCACAGAAGGCCTCCCGGGTAAAGATGTGACTGGTGGGCT CCTTTCCTGCTATACTGGGGAGGGAGCAA >'990913a2-046.scf came from CONTIG 32 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-046.scf(l>454)

AGCTCATGTTAATAGAGAGATGGAGCCCAAGAACAGACAGCTCGGTTTCGAAATACAAGT TTAGGAAAATCTTATCTCAGTCATGCATAAATATGCAGGGATATGGCAGAAGACACCAGA GCAGATGCAGAGAGCCATTΓTGTGGATGGATTGGATTATTTAATAACATTACCTTACTGGG

GAGGGAGGATTGGAAAAAAAAATGCCTTTGTGACAGCTTCTTATCTTTTTATTGTTGTTTC TTCTTGTGGTCTTGTATGAGTGTGAATCATTCCTTCTTGTTATGNTNATTNGTAGTTNCAGT GAATGTGATACTTTTTATGATTTTTTCAAGTTTGAAACTTTATCAGTCTGTGTATAGACATA CGTTTNCTTTAAAATTATGCGTGTAA

>'990913a2-047.scf came from CONTIG 33 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-047.scf(50>534)

GCACGAGGCCGATCTCTGCGAAGAGCTGGAACCCCGGGACCTTGGCGAAGTCCAAAATAA AGAGTGTCGAGACGCCTGGTGTGTGTTGGTGTTGTTGTGNGCGTGCACGCCTGTGTGGGTG TGGGGTGTGTGTATGTGTGGTGTGTGTGTGTGTCTCTTTGTGTGGTGTATGTCTGTGTGTAT

GTGGCTGGGTGTGTCTGTGAGACTTGCCCGCGCGGTCTTGNGCCCCGCGCTTCCCGGGGCG CAGGTGCATTGCAGACGGCACTGGGGTCCGCCGAGGGGAGCCTGGTGCTGATTTTGGTCC TCCTTCACCGCCCGCCAGCCCTGGGAGAGCCTTTGTTCAGCTGATGTGAGGGCTCCTGTTC TAGTCATGCCTGTCTGGACAACGATCAAGTCCGAGCACGCGGGGAGGCCCTAAACCCACT GACCTCAACCAAAAAGGAGGCGGACAACAAATCTCCCACCTGGGTGTGGGGTTGGGAAG

G

>'990913a2-049.scf came from CONTIG 34 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-049.scf(8>579) CGGCGTCTATAATAGNGGTCCCCCGGGCTGCAGGCGGGTGCACGGGTGGCGAGCGCAGAC

GGGAGAGGCTGCCAGACGAGCACCATGGCTCCCTGCCCGCTTCGCCCGCTGCTGTGGGTC CTCGTGCTGGGGCTTGGGCTGGCGCTGCTGCGCGCCGCGGGCGGGGAGGGAGTGCCAGGC ACCACCCCCTGCTCTCGCGGGACCTCCTGGAGCGCGGACCTAAACAAGTGCATGGACTGT GCCTCGGGCCGGGCGAGACCGCACAAGGACTTTTGCCTGGGCTGCACTGCGCGCCCTCCA GCCCCCCTCTTGTTGGGTGGGGCATTCTGGGGGGGCCCTGGGCTGGCCCTGGGCTGGGGT

GGTTTTTGGTGCTGGGCTGGGAGGGGGCGCAGAAAAGAATTTTACACCCCATCGGGGACG GGGGGGAGTGGCTGGGGGGCCTGTCAGGCGGGGCGCCCCGCCGGAGAGGTGGGCCGTCT

GGGAAGGATATTTTTTAGTTGTCCATTTCAAG >'990913a2-052.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-052.scf(8>705)

CGGCGTCTATATTATCTGTGCCTCGGCCTGTTTGCTGCTCTCTAACATCCATACTTGTACTG TACTTTCACCTGTGGACCCTCTCCACATCAGACTTTTACTGTCCCTTATGGTTGTATACATT

CCAAACCTATTCCAGTTGGTCCCAAGTGTCCATCCCTTATAACTCTGCCCTTGCTATTTAAC CTCCAACTAAGGTGGTCTAGATTTCCCTGATGGCTCAGCTGTGAAAGAATCCATTTTCAGC GCACAGGAAACCAGAGACGCAGGTTCAATCCGTGGGTCGGGATGATCCCCTAGAGAAGG AAATTGTCTCCCACTCCAGTTTTCTTGCCTGAAAAATCCCTGGACAGAGGAACCTGGCTGC TTCAGCGCAGAGGGTTGCACAGACTCACACCGACTGACCACCTACCACATTGCTATGTGCT

TTCTTTTTTATCTTCTCATGCTATTGCCAACCTGAATGCGACCTAACAGACCTGAAGAGGA ATAAGAGAAATCTTCTGACGAAAGCATTAAAAAGCAGAAAGCCTTAAATCGAATATCTTG AAAGACTCATACATTAGAAATTGCTATGTTCTTAAACTCAACATTTCTCTTTTACCTCAACC TAAAGAACCGTCCGTTCCTGTTTAGGGGAAATAAAAATCACACTGCCACCTAACCAAGGA ACATAAACATTTACTTCCTCCTCCTCT

>'990913a2-051.scf came from CONTIG 35 at offset

34;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-051.scf(47>556)

CTGCAGTCTAACATCCAGCCTTGTCCTGTACTTTCACCTCTCACCCTCCCACAGCAGCTTCA CTGCCCTTATGGTGTAACATCCAACCATTCCAGNGGTCCAAGAGCCACCCTACAACTCTCC

CTTGCTATTTAACCTCCAACTAAGGAGGTCTAGATTTCCCTGATGGCTCAACTGTGAAAGA ATCCATATACAGNGCAGAGGAGACAAGAGACGCAGGGTCAATCCGCGGGTCGGGAAGAT CCCCTAGAGAGGAAATGGTAACCCACTCCAGTATTCTTGCCTGTAAAATACATGGACAGA GGAGCCTGCGAGCTCAGTGCAGAGGGTTGCAAAGACTCTACACGACTGAGCACTANCACA TGCTTTGTTGCTTTTTTTTTTTTATCTTAGTTATTGACAACATGATGGACCTACAGTACATG

AGATGGATACAAGGAATATTTGTCGGAGCAATAAGAAGTAGAAGGATTGATTGAATATTT TTAATGACTATACATTATAAATTTC

>'990913a2-053.scf came from CONTIG 36 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-053.scf(48>595)

TCTTGTTGAAATGAAATACCACAACAAAAAGCAAGGAACAATGAGCAAGAGAAAGGAGA GCTTTTAAAAAATTAACTGGACCACTTTTGGGGGTTGGGGAGCAGAACTGCTTTTGGTGAT CTCACGTGACGTGTGAAGGTACACTGTGCTTCTTTGCTTCAGGAAATATAGGGTTGTCTGC AAGGAACCCAAGGTACAGCCAACGGGCGGGGGGTTTTTTCAAATCCCAAACTCACCGACA GGCGTGAATGTTCCTTGTAGTCCTCTGTAGACTGTGTCCTGGCCCTGTCAGCCCTTCTTCAG

CCTGCACCCTGTTCCAGAGCCAGTGAGACGGAGACACTGTGATGGAGCTCTCACTTCCAA GTGATAGTATTATTAATTTGTGTGTGTCAGACTATGACTCAGATGTGGGTGGATTTTTATTT AACGATAATGACATTATAAAACTTTATTTGTATTTGTATTTAATATCATTTCATTTTTAATC TTTATTTGAGCACGTGTTAAAATTAATACTTTGGTT^^

>'990913a2-054.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-054.scf (52>252)

GGGCACGAGGTAAACCCAAGCCCTTGACCTCTTACAGGAGCTTTGTCTGCCCTCTTAATAA CATCCGGCCTAACCATGTGATTTCACTTTAACTCAATGACCCTGCTAATAATTGGCCTAAC AACAAATATACTAACAATATACCAATGATGACGAGATGTTATCCGAGAAAGCACCTTCCA

AGGGCACCATACCCAGCTG

>'990913a2-055.scf came from CONTIG 38 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-055.scf(277>558) GAGGAGAAACTTCACGGNGGTCCCCAGNTGGATTTATTGTTGAAGGAGAACCACCAGGAA

AGGGTTCCCACTTGCTCTTGGTCTGCTGGCCACCTGCTCTCAAAAAATACTACCTTGCAGA CAAGATGCTACGGATGAGGAACTGCAACGAAAGATGTTTTTTGAGGTCCAGATGGGATGT GCGAGGCACACGATCACTCCTGTTGTTGTGGTGTGTAAAAAAGATGGAAAGAAATATAAT TAAAAAAAAACACTGCTGCTTTTTGTTTGTCTGGGTTGGGG

>'990913a2-056.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-056.scf(46>533)

TGGGACGAGGGTCAATCCTAGACATTATAATGCATGGTATGGTTTAGGAATGATTTATTAC AAGCAAGAAAAATTCAGCCTTGCAGAAATGCATTTCCAGAAAGCACTTGACATCAACCCT CAAAGTTCAGTTTTGCTTTGCCACATTGGGGTAGTTCAGCATGCACTGAAAAAATCTGAGA AGGCTTTGGATACCCTAAACAAAGCCATTGTTATTGATCCTAAGAACCTTCTATGCAAATT TCACAGAGCCTCAGTTTTATTTGGAAATGAAAAATATAGTCTGCTTTACAGAACTTNGAGA ATGATCACATNGTTCCCAANGATCCCTCGTTACTCTTAATAGAAGGTTAAAGAGTTAGTCA ACGCACTCGCCTGTGATNTCTTTGGGTTGGGTAAATCCTAAGACCAATACCAATAAAAGC

AATGTAACCTACTTCAAGAGAGAGCATACCCAGAGAAAATATGGACAAGATCCAGAGAG AGAG

>'990913a2-057.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-057.scf(48>291)

TCCATACGGCGTTGTCTTGAATTCCCGTCGTAACTTAAAGGGAAGCTTTCACAATGTCCGG GAGCCCTTGATGTCCTGCAAATGAAGGAGGAGGATGTCCTCAAATTCCTTGCAGCAGGAA CCCACTTAGGGGGCACCAACCTTGACTTCCAAATGGAACAATACATCTACAAAAGGAAAA GTGATGGCATCTACATCATAAATCTGAAGAGGACGGGGGAGAAGCTTCTGTTGGGCGCTC GGC

>'990913a2-059.scf came from CONTIG 41 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-059.scf(46>612)

TGCTGGTGCTGTTGGCCCAAGAGGTCCCAGTGGCCCACAAGGTATTCGAGGTGACAAGGG AGAGCCTGGTGATAAGGGTCCCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGGTTGCA

AGGGCTCCCGGGTCTTGCTGGGCATCATGGGGATCAAGGGGCTCCCGGGGCTGGGGGTCC CGCTGGGCCCAGGGGCCCTGCTGGTCCTTCTGGCCCCAGCTGCAAAGACGGGCGCATTTG ACAGACTGNNGCACGTGGACCTGCTGGCATTTCGTGGCTTCAAGGTAGCCAAGGGTCTGC TGGCCCTCCTGGCCCCCTGGCCCTTCTGACCTCCTGGCCAAGGGGGGGGGTTCGATTTGGG TTTGTGTGACTTTTCAGGCTGCCCACCCTCCTACTACTCTCTCNACCCAGATTTGAANTGTG

CACTTGTATCTTCACAACAATTGAAACTTTTTTTCAAAGCTTTAGAAAACCCCTCGCATCC CGACTTGACCACCCCCCAAGGGACTGTTTTATTGTTGACTATCCAAGTGTCTTGTTGTTTAA GTTTTTTTTTTTTTGCGAACT >'990913a2-075.scf came from CONTIG 41 at offset

534;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-075.scf(48>547)

CGGACATTCAGACAGAACGTGCGTACCAAAAGCAACCGACCATCTTTCAAAATAAAAAGA GGGTCCTGCTTGGAGAAACTGGCAAAGAAAGCTCCCTGATACTACAGAACTTGGTCTGGG CTTCAAGACTCCAAAGGAGGCCATCGAGGGCACCTACATTGACAAGAAATGCCCTTTTAC GGGTAATGTCTCCATTCGGGGCGGATCCTGTCTGGCGTGGTGACCAAAATGAAGATGCAG

AGGACCATCGTCATCCGCCGAGACTACCTTCACTACATCGAAAGTACAACCGCTTTGAGA AGCGCANAGAACTNCCGCGTGCACCTTTCTCCTGCTTAGGGACGCCAGATCGCGACATGT CACGTGGGCGAGTGCGGCCCTGGCAGACTGGCGCTCATGTCTCAGGTCACCAGCTCCGCA CAAGAGCATTCGAAGTTGAATGGCCTTGCTGTCCCAACACATAGTATTNCATTCAAAAAA AAAAAAAAAAAAATAAAAAT

>'990913a2-060.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-060.scf(52>263)

GCACGAGGCCCTTCTTCACCCCTTGCCCCTCGCCATCACCCCGACTCTCAACACAGCACAA ACCCTGCAAACCCAAAGAGAATATTAATACTTGAAGCAAGAAGGGTGCATGCCAGTCCCT

CTCAATCATGGCCAGGGGATGCCAGGGCTTGCGCCCCTGGACTCCTAGCCCTGCCCAGGG CAAGGAGGGCTTTTCCCTAGAGCTACTGGGC

>'990913a2-061.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-061.scf(54>571)

GCACGAGGGACTGTTTTCATCAAGAATAGTCTCTTGAGAAAACTTCAAATTTACGCTAACA AAAGGTACATTTGCCTCAGGGATGTCAGTATTTTTTAGAAGCTCCACACATGGCTGTATCA TAAAGAAAACTTAGTTGAATTATTTTGACTGCTGTTTTCTGCCCTGTACTGGAGCTTTAGG GTTGCTTGTTGACTTTGGGACAACTTTGGGTGATGAGGCTGCAGCTGATTTCTATCTTGATT CATCAGGTACGGGAGTTTGAGGGCGCAGTCATAGCTCTCTTTATTTACTGGCCACCNAGAC

AGACNAAAGTCGAGCCCTGAGGGAGGCTTTTATCGTCAGAATTTGCCCATCTCATGACCTC ATGCCACAGTTTTCGTGTTCGTGTTGTATATTTTTAGGTTCCGTGGGACTGCCATCAGTCAG CCGACCGCGGCAGACAGCACTACCCCTCAGCTCTCTAACTCCACATCCTATATTCTCTGCG CCTGTGCCACCTGCTGATTTCAATGCTT >'990913a2-062.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-062.scf(49>602)

GTTTCTGCGACCTGTTCTCGAACGCTCAGCGTGGTCCTCCTTCCGATTTGGAGATGCCTGTC TGGGGGAGGTGGCAACAAGTGCGGGGCGCTGTGGGGAGGACACGGTACCACGGCCGAGG

AGGTGCAGNGTGACGGCCGGAGCTTCCACCGCTGCTGCTTCCTGTGCATGGTTTGCAGGA AGAATTTAGATAGTACAACAGTGGCAATTCACGATGAAGAAATCTACTGCAAATCCTGCT ACGGAAAGAAGTACGGGCCAAAAGGGCTACGGGTACGGCCAGGGCGCAGGCACCCTCAA CATGGACCGGGCGAGAGGTTGGGCATCAAGCCGAAAGTGTTCAACCTCACAGACCGACAC AAATCAAACACTTTAATTTGTCAGAATTGGAGGTGCTGGAGTGTCAGATGTGGGTTCCGTT

CGCTNCGATAGACTTGTAGCTGAAGCCTGCACAAACTGTTCGTGTGCTAGGCGGGAGGTC TAGTCTACACTTGATGAGAAAAGTGAATTTTGTAGATGTCCGAGACTCGCCCAGTTTGCTT CGCAGGCTGGCC >'990913a2-063.scf came from CONTIG 45 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-063.scf(47>258)

GCACGAGGGAAAGTTCAGACATCAGGTAAGTGTGTTCTAATTAAAAGATCATGAGTTCAA ATCCCAAGCAGGGTTTTAGCTGGATTTGAGTCCTGGCCATGTGGGTTTGAGTCCCAAACTA GGTTTTTGGCTAGATTCAAATACTGGCACATGGGTTCAAGTGCCAATATGAGGTAAATGG NTTTAAGACCATTTAGGTTTTTGTATTCTTT

>'990913a2-066.scf came from CONTIG 46 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-066.scf(47>584)

CGCCGGCCCCAGCGCGCTGCCACCGCTGCCCACCCACCATCAACCAGCATGTCCTCCGCTC ACTTCAACCGAGGCCCCGCCTACGGGCTGTGGGCTGAGGACAAGAACAAGCTGGCCCAGA

AGTATGACCACCAGGGGGAGCAGGAGCTCCGAGAGTGGGTCGAGGGGGTGACGGGGCGC CGCATCGGCAACAACTTCATGGACGGACTTAAAGACGGCATGATTCTTTGTGAGTTCATCA ATAAGCTCCAGCCAGGCTCCGTGAAGAAAGTAAATGAGTCCACTCATAACTGGCATCAGC TGAAGAACATCGTCAACTCATCATGCCATCACCAGTCGGGGTGAAGCCCTACGATATCTT GAGGCCACGACCTGTTCGACACACCACCAACGCAGTGCATCACCTTTGCGCTGCCAGATG

ACAGAGAAAGGACAGGNGATGGGGAGGAATAGCGGAAGCGTACGTGATTGAGCAAGAG CTAAAGAAGCGACATTNGTGTCAGTGGACCCAGTGCAGCAGAGCTGAGGTACGGCCGCG

>'990913a2-067.scf came from CONTIG 47 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-067.scf(290>553)

AACTTGAGTACTACACAAGCTGGCTGGATACTGGGCCAGCATCACTCCCACGCTCCTTTCA CTGTACCAAAGACAGAGAAATGTCAGTTGGGAGCCAGGGACATGTCATGTCCGCAGTACA ACTTGATCTGATGTGTGTGAGAGGACGTTCTTCATTCTCCACTTGATACAGCACCTATCGA CAGGACCCCACCCACTTTGTTTTTATGATTACAGTTTCGAGTCCTTGCCTTCCTCCCACCCA CATACCTGACTTACCTCCCT

>'990913a2-069.scf came from CONTIG 48 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-069.scf(48>147)

GCACGAGGCCCCGCTGAGAGGAGGCAGCCAGTGCGACTCCCACCGCCCGGCGACCCACCT TCCTCCAAGTCCGACGGGCAGCCGCCCCCGGGGCGACAAG

>'990913a2-071.scf came from CONTIG 49 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-071.scf(55>586)

GCACGAGGCGAGTTCGACGGGAAGAGGTTCCAGAATGTTGCCAAAGAAGGAGTGAAGTT TGATGAAAGTGAGAAAAGTAAGGAGAGTCGTGAAGCAGTTGAGAAAGAATTTGAGCCTC

TGCTAAACTGGATGAAAGATAAAGCACTCAAGGACAAGATCGAGAAGGCTGNGGNGTCT CAGCGCCTGACAGAGTCTCCGGGTGCTCTGCCAGCCAGCCAGACGGGCGGGNCTGGCACA TGGAGAGGATCATGAAAGCCCCAGCATACCANACAGGCATGGACATCTCATCCATTATTA TGCCACCAGATAAAACATTΓGTTTTAACCCACCACCCACTATCATAACTGCTTGAAGAGTT AGAGAGAGATGAATACTGTCAGATCTGTGTGTTTGTTGAACACACCTCGTCTGATTCTTTG

CAACCTAAGATTGAGAAGATANATGATCTCGCTCACTAACATCACTGTGCAAGTGAGAGA CCAGAGACTGAGACACAAGCACGAAGAACAAAGATAAAGAGGAGACAGACGAC >'990913a2-072.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-072.scf(55>600)

GCACGAGGGCCTGCCTGCCCAACCTGGACCGCGTGGGCCACCCCAAGGAGCGCTGCTTCG CCTTCTGATGGACGGGCCCTGCTGCCCGCTTTCACTGTACCCTGGCCACACCCACCCCTCC TGCCGCTGTTCATTAACACCACCCGCCCCACGTCTCCAGCTGCGGACGGGTTCAGCCTGGC

CTGCCCGTGCCTGGGAGGTCACCCCGCTGGGCTGGCCCCTGAGGGGCCCCTTTGGGAGCA GGTGTGTGGTACAGGTGGGCTGCTGTTGGCCACCTTTAAGACAGATTCCTGTCTAGGCCTC GCCGGAGATGTTCCTTCCCTCTCGNCCCTCCACATACACACTACTGGTGGAGGCTGCCAGC ACCATGCTCCCAACTCCCAGACATCCACACCTGGAAATTAGAGAAAGTACAGCAACCTTA CTACAGCGCAGCCTCACCACTGAGACATGNCTNCNCCCTGCTGTTAGACCCGCCAGCTTCA

AGTGAACTATGTACTGAACCATAGTCCATGGATGGCTGTGGTTGAGTGNCNACACCAAGC C

>'990913a2-074.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-074.scf(55>269)

GCACGAGGATAAGACCAATTGGTATAAAACAAGATTACTAGGAGGAAAAAGAAAATATT GTGGTTTAGAACTGGTACTGGAGAAGGCAATGGCACCCCACTCCAGTACTCTTGCCTGGA AACTCCCATGGATGGAGGAGCCTAGGGGGCTGCAGNCCATGGGGGGTGCTAAGAGTCAG ACATGACTGAGCGACTTCGCTTTCACTTTTTACTTTC

>'990913a2-076.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-076.scf (49>616)

GAGCTCCAGGACCGACAGGATGGGGTCAGCCTGCATCAAAGTCACCAAGTACTTCCTCTT CCTCTTCAACTTGCTCTTCTTTGTCCTGGGCGCGGNGATCCTGGGCTTGGGATGTGGATCCT GGTCGACAAGAACAGTTTCATCTCCATCTTACAGACCTCCTCCACCTCGTTCAAGGTGGCG

GCCTACGTCTTCATCAGACGCGGGGGCCCTCACCATGCTCATGGGCTTCCTGGGCTGCCTG GGNGCCGNCAAAGAGGTCCGCTGCCTGCTGGGATGTACTTTGCCTTCCTCCTGCTGATCCT CATCGCCAGNTGACTGCCCGGGTCTTTTTCTATTCAACATGGGCCAGCTGAAGCAGGAGA GGGCAGCATCGTGACAAACTATTCACACTACACGACGGCTCGNGACAATTGCAGAGCCTG GATACTGCAGCTTAGGAAGTGTGGGCTGGTCAATACTCATGNAAGAAAACGACTATGATG

ACACACACTTCCTGTCTGGAAAATGAGAGAGAGCTCTGAGCCAGAGGTNNTTGAGTCTTG CACAGACAACGCAAACCCAAAAG

>'990913a2-077.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-077.scf(53>548)

GCACGAGGCTGAGGCTCGCTCTTTGCTCTGGGGATTCTGTGGCTTTTCCCAGTGCTAACCC ACTCAACAAGAAACGGTTTACCAGACCATACAGACCCAGAAGACAATGAAATTGTCTGCT TCTTAAAAGTGCAAATAGCTGAAGCAATTAACTTACAAGATAAGAACTTAATGGCTCAGC TTCAGGAAACAATGCGTTGNGTGTGCCGCTTTGATAACCGGACCTGTAGGAAGCTGTTGG CGTCCATCGCCGAGGACTACAGGAAGCGGGCCCCCTACATTGCTTACCTCACTCGCTGTCG

ACAGGACTGCAGACACGCAGGCTACCTGGAAGGCTCTGCAGAGGTTCTGCGGACAAGAGT GGCCATCCTACTTACCACGCTGTGTGAGTGTGCTTGGAGAAGAGAGAGATCAGGAATATT CAGATTTATAATACAGCGTGTGTAAACCCCAAGTGAGATTTTGCAGTCTGTCGGCGATGCC AGAGCATTGGANA

>'990913a2-078.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-078.scf(49>453)

GCACGAGGCTGTGGCTCGCTCTTTGTTCTGGGGGTTCTGTGGCTTTCCCAGCGCTAACCCA CTCAACAAGAAACGGTTTACCAGACCATACAGACCCAGAAGACAATGAAATTGTGTGCTT CTTAAAAGTGCAAATAGCTGAAGCAATTAACTTACAAGATAAGAACTTAATGGCTCAACT

TCAGGAAACAATGCGTTGTGTGTGCCGCTTTGATAACCGGACCTGTGGGAAGCTGCTGGC GTCCATCGCCGAGGACTACAGGAAGCGGGCCCCCTACTTGCTTTCCNACTCGCTGTCGACA AGACTGCAGACACGCAGCTCACTGGTAGACTCTGCAGTGGTTCTGNGGGACAAGAGTGGC CATCCTACTTACCACGTTGTGTAGTTGTGCTGGAGAAGAGAGA

>'990913a2-079.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-079.scf(49>483)

CCCAGGCCCAGGCGGCCTGCCTATCCCCTCCTACTCCCGTCGCTGCCTCTCCCACCCCTGT ATCTGCGCCCGGAGCCAGTTTGTTTGTCCAGCGGCGGCCTCCGCCGCTCGAGCTGTTTGCG GAGCTTAGCGCGCCGCCGCGCAGCGCCGGCCCAATTAAGTCTAATTCATTATTCAGCGCCC CAGTGCTCCCGCGCCCAGCAGCTGGCGGCTCCAGCGTCACTTTGATGCCCCTCCCAGCCCT GGCCCCGCCGTGAGTGCTAGGGAGCAGACAGAGAGAGCTGCTTTCCCTTCTCGGACCGAG AAGAGACTGAGGGGGTGGGATGTANNGAGGACAAATCTGTGACTGTGGGAGCGACGCGC AGCCNTCGACCACCCCACCACATAAAATGGAACTGANATCACCTTTTTTTAAAGAGGAAC

GGCCCCCCTACT

>'990913a2-080.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-080.scf(54>301) GAACGAGGGCGGGAGCTGGGGTCTCTGGAGCGGGATGGCAGCGGGAGCCGGCCGGAGTT

GGTCCCTAGGCTCACAGATCCCGCTCTCTGGCCTGAAACATGGCCCGGGGGACCTGGCCC TCTAACCCGGCCTCGCCCCGACACGGCCGCCATGCCCAAGAGAGGGAAGCGACTCAAGTT CCGGGCCCAAGACGCCTGCTCAGGAAGAGTGACCGTGGGGGATTATGCCAACTCGGATCC GGCAGGCGG

>'990913a2-081.scf came from CONTIG 55 at offset 0;Ε:\SEQUENCE\export\EG_DB\990913a2\990913a2-081.scf(54>687)

GAACGAGGGCGGGAGCTGCGGTCTCTGGGAGCGGGGTGGCAGCGGAGCCGGCCGGAGTT GGCCCTAGCTCACAGATCCGCTTTGGCCTGAAACATGGCCCGGGACCTGGCCCTCTAACCC GGCCTCGCCCCGACACGGCCGCCATGCCCAAGAGAGGGAAGCGACTCAAGTTCCGGGCCC

AAGACGCCTGCTCAGGAAGAGTGACCGTGGGGGATTATGCCAACTCGGATCCGGCAGTCG GGAGGGCTGGAAGGGGCAAGAAAGCTGGTCGCCAATGCTGTTCATAAGAAGTAAAATCT CTCTGTGGCTTGGAAGCCTCCCAGGTTCCGGCAGTGGTAGCTCTTTCTGGGGCTGTGAGCC CTGGACACATCGAAGAAGAGGGAACTGATGCCCAGAGAAAGATACATGAGAGACTACTA CAAAAAAGAAAGCAGAGAACAAGAGACCGAGGNACGGAGAGAGAGATCCAGGATTTTG

GTTTGTGCCTCTTATCGACTGAGAATTGGATTTTCCTGATTGAGACGCCGACTGCCTGCCC TGTGCTTTGACAGGGACGAACATAACACGATCCTTGCCTTGCCGCACCGACAAGAAAAGA CGCTCGCTGGGTCGCCTGCCATTTGGCTTCGTCGTT >'990913a2-082.scf came from CONTIG 56 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-082.scf(55>136)

GCACGAGGCTTCTCCAAGCATCACCCTGGGGAGTGTTTTCTAGACTTTTTCTCATACATGG

GGAGCAGTAAGGTTTATCTAT >'990913a2-084.scf came from CONTIG 57 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-084.scf(42>252)

ATAGACCTGTGGTCTTACATACACGCACCCACACACACACGCATTTATGTTTTTTTTTTTTA TTTAGTGGCTTGAAAAATGAAGAAAATAATGTTTTTTGCTTTTATGTGGGAAATCATGGAA TACCATACGAGTTAAGGCGTTCCTCTTTTCCTCTTCGCTCACCCACGGGGTGACACCCACG CTCCCCCACACCACTCATTGTTGGGAT

>'990913a2-085.scf came from CONTIG 58 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-085.scf(55>578)

GCACGAGGGCCCGGCGGAGTGGGGGCTGGGGGTGGCCATGGATGATGATATTGCTGCGCT CGTGGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCTCCCCG

GGCCGTCTTCCCGTCCATCGNGGGGCGCCCCCGGCACCAGGGCGTAATGGTGGGCATGGG CCAGAAGGACTCGGACGGGGGGATGAGGCTCAGAGCAAGAGAGCATCCTGACCCTCAGT ACCCCATTGAGCACGGCATCGTCACCAACTGGGACGACATGAGAAAGATCTGGCACCACA CCTCTACAACGGCTCCGTGTGGGCCCTGAGAGCCCCCCGGCTGTGACCGAGCCCCCTGAC CCCCAGCAACCGGAGAGATACCAATATGTTAGACCTCACACCCTCCATTACCGGCCTTCA

GTGGCTGCCTGTTGCCTTGCCCACCACGATCGGAGGATCGTGACGGTACCCCACGGCCATT AGAGTTACCCTTCCTGCATCTCTTGACCGGTGCGGACTGCGACA

>'990913a2-086.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-086.scf(49>646)

GGAAAAGGACCGTGGCCCTGAGGGCCAGTTTGTGATGGGTTATGTGGTACGACTGCACAA TTTTCACCAGCTGTCTGCACCCCAGCCCTGTTTTACCTTCTGCCATCCTAACAAAGATCCTA TGATTGACAACAATCGCTACTGTACCTTGGGGGTTGCTGTGGAGGGGGACACAGGGCTGG GTGGGTTTGCAGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGAGTATCCGGCC AGAGACTCACTCTTCTGGGGTGGTTTCATGGTTTCCCATCCTCTTCCCCATTAAGCAGCGC ATTACGGGGGCGGAGGCCAGACCTCTGGTGCGGTGTGGCGTGCAGCACTCTAGAAGGGGG GATGAGGGGCTGGACGGACGGGCTGCTTGCTTCACACCCCACAGCGTCTACACATNGCTC TACCCGGCGAGGGCGAAGCGGGAGAGCGAGATTGTTCGAGCCAGAGGGAGACACTGGCT TGTCGCGGCCATCAAAGACTTAGCTGCTTCTCCTCTCAGAGCAAGGGATGGGCCAGCACC

ACGGAGATAGCCGGAGGGATAGTGTTGGTTCACGCTCGCCAGCCCGGAGCGGATG

>'990913a2-088.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-088.scf(217>525) AGCATGATAGACAACTTCACTCCTTTGCTCCCCCAGGGCCACCCACCCCACTCACACCCAG

CGAGGGACTTCCACCCCCACGCAGGGGGTAACCCTGACAGCCCAGGAGGACTCACACCTC CTCCGTCCGGCTGAGCCCCTTGGGTCCTGGGAGAGACTCTTCAGCTGGTTCCTCCTCGATC CTCGCCCCCCGCCCGGNGGGACGGGGTNGCAGNGAGGCGGGTGTGGCTGAGGGGGGCTC GGGCTGCCCGGCTGAGGGTGGGCGGGGGGGGGTTCTTCTGGCTGGAGATGGGGGGTGGTC TGTTAATC

>'990913a2-090.scf came from CONTIG 61 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-090.scf(56>651)

GCACGAGGGTTTAAAGTAAGCTCTGTTCCTTTCAATTCAGTCGTTCAGTTGTGTCCGACTC TTTGCGACCCCATGGGACTGCGGCACGCCAGGCTTCCCTGCCCATCAACTCCCAGAGCTTG

CTCAAACTCATGTCTGTCAAGNCGGTGATGGACTCTGTTAGAGAATTTTAAATGCTATCTC TGTGTTTAGGTGAΛGCAGTACCACTCTGTTTTTAAGTGTTGTGTGTAGCTGGACACTGTTC AGATTACTTGCTTCCATCTTGTCTCTCTCTCACATTTCATTATTGAAGATTTATGAATATAC AGAGNAAAGAGAATAGTATCAGAACTGCCATGATTCATACCCAAGTCAAAAATAACACTA CAGCTAGCTGATTATTATAATGCNTCCACACCTCACTCACTGATTTTTAAGTAATCTACAT

GTATATTTTTNTTAATATTCATGCTGCTTAAAATAGAATCTTATTCACTAACACGACTCTTA GCTTTAAATGCTGATTCTAGTGTCAAATTGGTTTAT^^ AAGAATTTAAGTTTTCTTCAATAAAAGTTGTTTTTTTTATTCAAA >'990913a2-091.scf came from CONTIG 62 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-091.scf(51>168)

TTTGGGGACGAGGCCAAAACGAATGCTTGGCTGCAGACAGGGTGGCCGCTTGGGCCCCCT

CGGCGCGAGCCCACGTAACTGGTTTGTACCGCTTTTGTGGCCGTGTTCTACGCGCGAC >'990913a2-092.scf came from CONTIG 63 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-092.scf(56>355)

GCACGAGGCCGGCCCCCTGCTGCTCTCACCCCAGTGCCCCTTTCCCAGGGGACCTCTCCCA CCCTCCTCGAAAGAAGGACCGAAAGAACCGAAGTGGGGCGCGGAGGGGCGACAGGCTTT GGGGTACTCCGGAGGCCCCGCCCAGCCCCTGGGGATGGGGAAAAGAAGACTCGAAACAA GAAAAGCAAGAAGCGGAAATTGAAAAAAGCAGAACGAGGGGATAGGCTCCCACCTCCTG

GGCCTCCCCGGGCACCCCCCAGCGATACAAACCTGAAGAGAAGAGGAGGAGAAGGAGGG GGA

>'990913a2-093.scf came from CONTIG 64 at offset 0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-093.scf(50>529)

TTTTTCCTGGGATGTGAGGCAATCTGTTGGCAAAAATTACATGTATTTGTCCTTCCTATTTG TAAGATTATATTTAATGATATTCTTTTCTTTATCAGAGACTCTCACTGCAGGCAGNGCTATT TCTTGTGCCTAAGACTATTTCTGAAAGTTGCATCACTAATGATACTTGCCGAGTTGAGGGT GCAGAAAGTTTCTCATACCATATTCAAGATAATACCAAGCACATGTGGCCGCTGGAGAGT GAAGCTGTAGTACAGAATGCGTAAATTCTGTCCCCAGGAAATCTGAGATAAGCAGGGCTG

CTGGGGTTTTTCCCCTACTCTGAGCTGTGTTCTTCTCTTTTGGTAGCCTATGCTGNATAATG GATGCTAATAGTAATATTTTATGCTAGATTCAGATTTGTCCTAGTAGTGTCTTTTTCTATGT AGAAACTTAACATGGATTTAGGGTGTGTGTTTTTTTAAAGGGAAGGAGATT >'990913a2-094.scf came from CONTIG 65 at offset

0;Ε:\SEQUENCE\export\EG_DB\990913a2\990913a2-094.scf(51>517)

CAATTATCAAGGAGAGTTGAAAAAAGGTGATAACATCTATAATACGAGGACGAGAAAGA AAGTGCGGGTGCAGCGACTGGTTCGCATGCATGCCGACATGATGGAGATGTTGAGGAAGG GTTTGCTGGAGACATCTGTGCATTGTTTGGCATTGACTGTGCCAGCGGAGACACATTCACA AACAAAGATAATAGCGGCCTTTCTATGGAGTCAATTCATGTTCCTGATCCTGTCATTTCTA TAGCAAGAAACCCGTCTAACAAGAATGATACTGAAAAATTTTCAAAGTTTTTGCAGGTTA CAGAGAAGATTCCACATTATAGTCACTTTGACACTGCAGCAAAAGACATTGNTTTGTATG GGAGATTACACTGGAATTTTTCTCACGAAGGAAGAGATATGNTTGCTTGTTTACAGAAAA CATAGTGTTTTAAGAATTTTTGTCCCTGTCTTTTCTTTCCATAAAA

>'990913a2-096.scf came from CONTIG 66 at offset

0;"E:\SEQUENCE\export\EG_DB\990913a2\990913a2-096.scf(58>577)

GCACGAGGGCACCACCAGCGGAAGCGCAACAACCTCATGACGCTGCCGGCGCACCGGCT GCAGCACCCCGTGCTGCTCTCCCGCCTGGTGGTCCTGGACCACCCCCACCGCTGCAACGTC

ACCTACAACGGCAACAACGGCATCCAGTACGTGGCCAGCCAGGCCGAGCAGAATGCGTG GGAAGTGGGCTCCCCGCCCTCCTACTCAGAGGCCCTGCTGGATCAAAGACCCGCCTGGTA CGACCTTCCTCCGCCACCCTACTCTTAGACACTGATCTTTGAACCAAGCCGACCTGCCCCT TACCGCTCCGGTCGTGCGTGCTGACAGCGCCGCTCCCAGCAGCCACAGCCTCTGAGCGTG ACACACCACCACACCCGGGCACCTGACCGCAGAGGCCCCGTGACCCAGGACTCGCCCCAG

CAGGCATGAGACAATAACTTGCTTTTCAGTTTTTTGGTCTTTCTTTGCTTATGTCTA CGCTACGAGTTCTCGGGCCTTAGGGGGTTGAGGGCGTT

>'990928a-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-001.scf(44>661)

GGACGAGGGGCAGCATCGGCCTTTGCAGGGGGGGCAGCAGCACCAGGCTCTGCAGCGGC AACCCCCCCCAGCGGCTTAAGCCATGGCGCTTTTCACGGAATTCAGCAGCAGCCTTGCTGT AACCGACAAAGACATCTTCGAATTAAACACATTCCTCGAGTTAAACACCAAAACCTCGCA ACATGGACGAGATGAACTTTCTGAGCAGGGAGGGGTGAGGGGGGGACTTCGTGTCCCCCT TCGACCAGTGGGGTGTGGGGGCGTGGAAAAGAGCCTAAGACTACTAAATGACAACCTGG

AGGGGGCCAAGCACTTCAAACATCATGGGTTCTCCTGCGAAAGGGTAAGCAGGCTCCTCC GAATGGCTGGTGTGGATGGTTGGNCTCAAAAACAGAAAGGAGATGCTTCTCCGGAAGATG GATGAGGAGAAAAGATTGAAGAGGTGATTTGATATCTGTAGAAAGAGACTGAAACAGAC AATGACCTGCCAGCCGAGAACGGGAACCCTTACCCTAACAGAAATACAAGAACCCCAAA CAACCAATGCACTCCAAGATACACATGACAGGCCCTCCTTTTCCCTTCCCTCCGCCCTGCT

CCCCTATΓCTTTTTATTAGA

>'990928a-002.scf came from CONTIG 2 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-002.scf(38>631) CTCCAGCTCCTTTCCATCTGAAGCTGAGTGACTCTCCATTGGACTGACTGGGCAGCCTGCC

TCCCCTTACCCGGGACGCCAGTACCGTCTCATTCTTGGGTACCAAATTTCCACTTTGCACC CCAGGTTCTCTCTCACATTCCCAAGTCCCCACTTTGAGTTCTTGTGTAGGAATCCCAAATTG CCTTTGGTAAGGGGCCCATCACTTACCTCCAAACTTTCTTAAGCCAATAGTCTTGCCTCTG AGCTACAAGCGCTACAGTAAGGGCCTGCTGCTCCATTTCAAGCTTCTTCAAAACTGACTCC TGCCAGCAAAGGGCCAGAAACTCAGTTTGGCTGCCCTGCTGGTCTCTGGGGGTCCATTTGT

ACCATAAATGCAATTTGGGAAGAAGAGGAGAAGCAAGNGGAGCCTGATTTCCTAATTATG GTTATCTGCTTCTTGTTCCTGTGGGAAGNTGGCTTACTGAAACAAAAGGAGCTGCTGCTTT ATGTGGGCTTTAAATTATCTACTATAAAATTTCAAATAATACTATTTTTTGTITTATTTTAA AACTATTTTAAATTTGTTTTTCTTACATAGTTAAAGAAGGAAAT

>'990928a-003.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-003.scf(44>582)

GAACGAGGAAATCTTATGTCATGGGTAGGCGTGTAATATGGGGACACTGTGTTTAAAAGA AAAGAAAAAAACAAAACCCACATGCCACCATTTTTCTGAATCAAATTCTACAGGGGAATG GGGGGTAAAGACTTCTACTGTGCAGGCAGCTAGATTGGGAAATGGGGGAACTAGAAGCA

ACGAGCACTGGAGAGCCCTCTACACTCTTCCCCGCTGGCATCCTATTGCTTTTTGGACTAT GAAGGAGAAAAGAAAAAATAGCAAGCACGTTCACATCCTTGCCCTGTTATCAACTGGGCC TGGCGCTCTGCTAGTCATTCCCTTCCTTTTTCCTCTATCCATTTGTCAACCCTTGAGAAGCA TGATTCACCTAAAATCCAGGACCGGGAACCTTGATNTGAGAGTCTGGGCTCTCTGGCTCTT TCTGCTCCTTGCAGAGCACCACCAGCTCTGCCTCAGCCACGCTCTCTGGCAGATGGAGATC

TGGCTTTΓCCTGCCACCCAACCATAGCATAGCTTAACATACACTTTATTAAAATA

>'990928a-004.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-004.scf(34>704) TATGTGGAAGTGATGGAAGTGGGGGTCCTGTGGGCCCTGCTGGTCCCATTGGGTCTGTCTG GCCCTCCAGGCTTCCCAGGGGCTCCTGGCCCCAAGGGTGAAACTCGGGACCTGTTGGTAA CTCCTGGCCCTGCTGGGTCCCGCGGGGTCCCCGTGGGTGAAGTGGGGCCTCCCAGGTCCTT TCTGGCCCTGTCGGGACCTCCTGGGAAACCCCGGAGCCAATGGGCTTTCTGGGGCTAAGG GTGCTGCTGGCCTTCCCGGTGGTGCTGGGGCTCCCGGCCTCCCTGGACCCCGGAGTATTCC

TGGCCCTGGTGGCGCTGCTGGGCTACTGGCACCAAATGACTTGTTGGTGAGCCCGGCCCA GATGGTCGAAAGGAGAGAGCGGCAACAGGGCGAGCCGGGGCTGCGGGGACCCAGGCCTC TGCCCCAAGGGAAAGAAGAAATAAGCTCACTGGAAAATCGACCCGCTGCCCCCAGAACTC TGGGTGAGGGAACCTGGTCCGGGGCACTGGACGACGCAACTGGGCATGGCCGCGGTGCG GGGCTCGGCTGTGGGGGAGGCCATGTAATTGGGGCTGGGACTGGCTTGGACCAGTTCCGT

CCTGAATTGCCATGTAAAGTTTGGTTCTGTTTAGGAATGCCTGGCAGGAAAAAAATGATTT TCTTCCACC

>'990928a-005.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-005.scf(12>609)

TCTACGGATCCCCCGGCCTGCGGGCTTAAGCACCAGAACAGGGGGAAATGGGCAGAATCA AAGGCAATTATGGGGCAAATAGGACCTGGAGGCTTGCCAGGCTATGCAGGAACAGCTGG CCAGAAACAAAAAGCTGACGCAGAAGGGCCGGGCGGGCTCTGAGAGTGAGGAAGAGGG GGAAGGACAGGAGGAGGAGGAAGAACCTCTTGTCCCTGACCTGGGGAATGAGGTGCAGA TAAAGGCAGATGGACTGAACCCCTGGATGTTCCGGAATCAATTCTTTGATGCCAAAGGAG

CTGAGGGCCACAAAGAACTGGAAGATCCTGCTGAGCCTGGAGCCCAGAAGACTTCTGAAA GAGAGGAAAAAAAAGCAGCGGGGGAGGAAGAAACTTTTTTGAAAGAATTTGAGGAAAGG GAAACACTTACACAAAACACTGACCTAATCAATGGGAGACCTGGGCACAAACGGAACAA AGGATCCTACAACCACGCAGGGTGCCGATTGAGGCCCTGGGCAGAAACCCCACGGAAAC ATAACCAGGAACAAAATGAATCACGGGAAAGACAAAGAGGAACGGGCGGGGGGAAGGG

CCTTGTG

>'990928a-006.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-006.scf(37>598) CTTTTTTGAAAAGGAAACTGAAAGAAAGAGGGCAAGACTATTTAAGAGCTGGTAGCTGCA

CTGGGCAGTCTCAGCTCCTCAGCTCCCGGGCGGGACCAGTGGGCCACCTCTGCAGGGGAC TCCTGCCACCGGGCTTGTCTGGACCACTGAGCAAATCTGCCAGCACCCCAACCAGCTGTG AACATCTTCCCAGAAAATGGCAGACATGTCCAATGGCGAGCAGGGCTGTGGGTCCCCCCT GGAGCTGTTCCACAGCATCGCTGCTCAGGGGAGCTCGTAAGGGACCTCAAAGCCAGAAAC GCAGCCAGGATGAAATTGATTCTGAGTGAAGATGTGTTGTCCTTAAAAAGAGCTACAAAC

TGCCACAGGGAGGATACAAGTGGGACTGTCCTCAGGGACCCGCGCCCGAAGGGGGAGGC TGGAGCCACCGAGCAACAGACTTGTGATNCTGGAAAGCAACAACAGGCCAAGCATGATA CACAGCTATTGTGATTGAACAGAAATGAAGAGTGNAAACGAAAAAGACAGACAAACAAC GCTCTGCAGTATTTTTTAACAAATC

>'990928a-007.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-007.scf(42>642)

GCACGAGGGTCAACATGACTGACAATGATCTTATCAATATTCTTGACCCTTTTTATCATCT TTCAACTAAAAGTTTCAAAACACAACTTTTATCACAATCCAAAACTGACACCAACAAAAA TATTAAAACAAAACACCCCTTGAGAAACAAAATGAACGAAAATTTATTTACCTCTTTTATT

ACCCCTGTAATTTTATGTCTCCCTCTCGTAACCCTTATCGTACTATTCCCAAGCCTACTATT CCCAACATCAAACCGACTAGTAAGCAATCGCTTTGTAACCCTCCAACAATGAATACTTCA ACTTGTATCAAAACAAATAATGAGTATCCACAATTCTAAAGGACAAACATGAACATTAAT ATTAATATCTCTGATCCTATTTTTGAATCAAACAACCTACTAGNCCTATTACCCCATCATTC ACACCAACACACAATATCAATAAACTAGCATAGCCTCCCCTGGAGCAGAGCCGGATTACA

GGATTCGCATAAACTAAGATCACTGTCATTTCTACACAGNACACCACTCCTATCCATATAG ANTATGAACTTAGTCTTTTTTACTAGTCTNCGGCGTACAGTAATATGAGAACTA

>'990928a-008.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-008.scf(42>463)

GCACGAGGCTCACATTCCTGCAGACCTCCAGACTGCCCGGAGCTTGCCTGCTGCCTGCCTG CCTGCCACTGAGGGTTCCCAACACCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCC GGGAGGGCCTTGGCAGCCCCTCAACAGGAAGCCTTGCCTGATGAGACAGAAAGGGAGGA AGAAACCGGGGCCGAGGGGGCCGAGGTACCCGCGGGAGCCAACCCCGTCCAGAGGGAAA TAGGAGAATTCGATGATGGTGCCGAGGAAACCGAGGAGGAGGNGGTGGCCGAGAACCCC TGCCACAACCACCACTGCAAACACGGCAAGGGGTGTGAACTGNACGAGAACAACACCNC ATGTGTGTGTGCCAAGACCCCACCAGCTGCCCTGCCCCCACGCCGAGGTGAGAAGNNGGC AGCA

>'990928a-096.scf came from CONTIG 8 at offset 35;"E:\SEQUENCE\export\EST_db\990928a\990928a-096.scf(38>418)

CCCGGAGCTTGCCTGCTGCCTGCCTGCCTGCCACTGAGGGTTCCCAACACCATGAGGGCCT GGATCTTTTTTCTCCTTTGCCTGGCCGGGAGGGGCCTTGGCAGCCCCTCAACAGGAAGCCT TGCCTGATGAGACAGAAGGGGAGGAAGAAACCGTGGCCGAGGGGGCCGAGGTACCCGTG

GGAGCCAACCCCGTCCAGGGGGAAGTAGGAGAATTCGATGATGGTGCTGAGGAAACCGA AGAGGAGGNGGAGGCCGAGAACCCCTGCCACAACCACCACTGCAAACACGGCAAGGGGT GCGAACTGGACGAGAACAACACCCCCATGTGTGTGTGCCCAGACCCCACCAGCTGCCCTG CCCCCATCGGCGAGTTGAGAAG

>'990928a-01 l.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-011.scf(36>481) TTTTATTTACAATGCTAAGGGCTAATGTTTT^ GTTGTTTATTTCCCCTCAAACTTCAACCTTTAATTAAATTATCATCTTTAAGCTTT^ TGTTTTAATGACTGGGGTCTTAGAGCCATTGATGTCTTATGTTTGTTTTTCAAATCATATTT

TTATTTCTGCTGTTGTGGATTTGTGTAGCTATTTGAATCATGGGCTGTTGCTTCCATTGAAG GATCTTCTGCCTTTTACTGTGGGATAACTGTTAAAATTTATGGTGAACTTTATAAGAGCTT ATTAGCATTAAAGCAGCCACCCGCAGAGAAAGGGAAACCAATCTGGAAAGCTGTGGAGT ACTCATAGAATACTAATATGAGGACCAAGGACTACTAGCAACCTGAGCCATTTCCACCTA AACGGGAACGCGTTGAG

>'990928a-012.scf came from CONTIG 10 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-012.scf(41>541)

GCACGAGGGAAAGATTCATTGGAGATTGGGACCAGGGGTTCAAAGATTCACTGGGGTTGG TACCTTACTCTCCAAAAAGAGCAATATAGAGATGTCTCACAAAGTTCATCCTAAACCTATT

TTCTAATTTGGGAAGCTAAAAGATCACAGGCAATGTAAAACATCCATTTTTATCACTGTCA TTTGTTTTCTTATTACCTCTCTCTAGTATCTTCCACTTCTAATTATATATATATTATATTTTT^ TTTTTTGGGGGGAGGGGGATAATAAGTCTTTATTTCACCATCAAATAAATTCAGGTCATGT TTAAAAAAAAAAAAAAAAACTGAGGGGGGCCCGTACCCATTCGCCCTTATGTAGTGTATA

CATTACTGTCGTGGTTACACGTGNGACTGGAAACCTGCCGTCCCACTATCGCTGCACCTCC CCTTGCCGTGGG

>'990928a-013.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-013.scf(40>603)

GCACGAGGCCTCACAGTGCCTGGCCAAGCCCTGGCCTGTGGGAGCAACAGGGTCAACAAG CTGGGCCTGGACCACCTCTCCCTAGGGGAGGAGCCTGCCCTACACCAGCAAGGGGAGGAG GCCCTGAACTTCACTCCATTAGGTTCTGCACCCCTGGACCAGGAGCCCCTGCTGAGTGTGG ATTTGGGCACTGCTCATTCAGCTGGTGTAACTGCCTCTGGTGACTGCTACACTTTCGGCAG CAATCAGCATGGGCAGTTGGGTACCAATGCTCGCCGGGTCAGCCGGGCACCCTGTCAAGT

CCAGGGCCTCCAGGGCATCAAGATAGCGATGGTGGGCTGGGGGATGCCTTCACTGTTGCC ATTGGGCAGAAGGGAAGGTACTCCTGGGCAAAGGGCCCGAGTNCGCTGGGAGAGAGAGN AGACGCCGACTCCTAGGCAGGCAGTGGAGAGACCACCCTACCATGACCTTGTGCCTGTGC CTGCACACTTCTGCTTCGCCTTACGAGAACATGCCCCTGCCACTGATCATCTGTACCTGAT GTTTCTGGAGTTGAAGGAGGCA

>'990928a-014.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-014.scf(41>599)

GCACGAGGAAGAATCTCTCTTTAGTTCTTTGTACGGAGGTGAAAAAAATAAAAAAATCCT TCAAAAATGGCAATGGTATCTGAATTCCTCAAGCAGGCCTGGTTTATTGAAAATGAAAAG

CAGGAATACATTAAAACGGTGAAAGGATCCAAAGGTGGTCCTGGGTCAGCAGTGAGCCCC TATCCTACGTTCAATCCATCCTCGGATGTTGAGGCCTTGCACAAAGCAATCACAGTTAAAG GTGTGGATGAAGCAACCATCATTGAAATTCTGACTAAAAGAAACAATGCACAGCGTCAGC AGATCAAAGCGGCCTATTCTGCAGAGAAAGGAAAGCCCCTGATGAAGTTCTGATAAAGCC CTCCTCGTCACCTTGAGAGTTGTTTTGCTTCTTTGAAACTCAGCCAGTTGAGCCGAGACTC CTGCTGCCTGAAGGCCTGGACGATGAGACCTTGATGAATCTGCATCAGACTACANNAAAT CAAAATACAAACTTANAAAACTAGAAAAATGCTAAGACTGCTCAACCTTGAATATAAGTT TGTGTTGTTGTGCCGTC

>'990928a-015.scf came from CONTIG 13 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-015.scf(40>545)

GCACGAGGGCCTAACACAAATTAAGAATATGTTTCAGTTTATATCATATTTCAAAACACAT TTAACTGTTTCTTAAAGCTTTACATTTTTAGTTACAACCTCCAGAGATTTTGAGCCTCAT^ TCTTCAATACTTGAAATAGAGGGAGCTAGAACACTTCATCATGTGTAATCTGATAAACCTG

CTGCAAGAGCCATAATTTTGAGGACTTTTCTAAGGGAATTGTGGGGATCCAGGATTTATAA TTTCTTGATCTAAACTTGCATAAAGGAAATACCACACGTGCACATTTCATAGTATGAAATA AGAAGTCATTTTTACACTTTATTATCTAAGTAATATATGCACCTTTCATAATCCATGTGTGT TCACTAAGCATGTTATATAATATGATTGACAGATTTGTTTTTTTCTANAATAAATATTTGTG GGGTTTTGTTTGTTACAATATCATTTTGCTATTAACATGCAATAGACGGATGTGCCTTTTAT

AAGATAGTTTCGGG

>'990928a-088.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-088.scf(36>595) CGAGATGGTTCTCCTGGCGCCAAGGGTGACCGTGGGGAGACCGGCCCTGCTGGGACCTCC

TGGTGGCTCCTGGGCGCTCCCGGGTGCCCCCGGGCCCTGTCGGGACCTGCCGGGCAAGAG GCGGTGGATCGTGGGTGAGACCGGGTCCTGCTGGGTCCTGCTGGGTCCCATTGGGCCCCG TTGGGTGCCCGTGGGCCCCGCTGGGACCCCAAGGGCCCCCGTGGTGACAAGGGTGAGACA GGCGAACAGGGCGACAGAGGCATTAAGGGGCACCGTGGCTTCTCTGGTCTCCAGGGTCCC CCCGGCCCTCCCGGCTCTCCTGGGGAGCAAGGGTCCTTTCCGAGCCTCTGGTCCTGCTGGT

CCNCGCGGTCCCCCTGGCTTGCTGGTTCTCCCGCAAAAATGACTAATGGTCTCCCAGCCCC ATCGTCCCCTGGGCTGNAGNNGAACTGGGAGGTGGTCTGCTGGTCTCCCGGCCTCTGACC CCTGNCCCCAGCCTCCACGAGATACATTGACTACTGCCCACCACCTAAAAAGATAGAGTG TCGGTATCGGCTTGTGCA

>'990928a-017.scf came from CONTIG 14 at offset 259;"E:\SEQUENCE\export\EST_db\990928a\990928a-017.scf(40>593)

GCACGAGGGGCACCGTGGGTTTTCTGGTCTCCAGGGGCCCCCCGGCCCTCCCGGCTCTCCT GGGGAGCAAGGTCCTTTCGGAGCCTCTGGTCCTGCTGGGTCCCCGCGGGGCCCCCTGGGTT TGCTGGTTCTCCCGGCAAAGATGGACTCAATGGTCTCCCACGCCCCATCGGTCCCCCTGGG

CCTCGAGGTCGCACTGGTGATGCTGGTCCTGCTGGTCCTCCCGGCCCTCCTGGACCCCCTG GTCCCCCACATCCTCCCAGCGGAGGGTACGACTTGAGCTTCCTGCCCCAGCCACCTCAATA GAAAGATCACGATGGTGGACGCTACTACCGAGCTGATGATGCCATGTGGGGCGTGACCGG GACTCGAGAGGACACCACCTCAAGACCTGAGCAGAAATCGAGAAATNCGAACCTGNAGC AGACGCAGACCCCGCCGACCTGCGGACTCAAATTGCACTTGATGGAGAAGGAGATAATGA

TGACCCACCAGCTGCACTGATGCATAAGTCTTGCAATGGAACGGGAGACTGGATACCCCT ATCCACGGAC

>'990928a-018.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-018.scf(34>577)

CGTTCGACAGATAGCCGGAACTTCTGTGCTGTGCCAGCCGCATCCCTGAGAAAAAGGGGA AGGTCGGAGTGAACGGATTCGGCCGCATCGGGCGCCTGGGCACCAGGCTGTTTTTAATTC TGGCAAAGGGGACATCGTCGCCATCAATGACCCCTTCTTTGTCCTTCACTACATGGTCTAC ATGTTCCAGTATGATTCCACCCACGGCAAGTTCAACGGCACAGTCAAGGCAGAGAACGGG AAGCTCGTCATCAATGGAAAGGCCATCACCATCTTCCAGGAGCGAGATCCTGCCAACATC

AATGGGGTGATGCTGGTGCTGAGATGTGGGGGAGGCACTGNNGTTCTCACTACCATGGAG AGGCTGTGCTCACTTGAGGGGGAGCCAGAGGTCATCATCTTGCCCTTTGCCAGCCCCCTGT TGGGAGGGGGGAACAGANAANATACACACTCAAATGCACATGCTCCGCACACACGCTGC CCCCGCCAGCATCTACACTTGCATGGAGACTATACATTCAGCCTCCTCACAAAATGGAGG CCC

>'990928a-019.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-019.scf(34>624) CGGAAACCACGTACCGGCAAACTGGCCTGGCTCCCGGGCAGGAGTATGATATATCCTTGC ACATTGTGAAAAACAATACCCGGGGCCCTGGCCTGAAGAGAGAGACAACTACCCGCTTGG ACGCCCCCAGCCAGATTGAAGGGAAAGATGTCACAGACACCACCGCTTTGATCACTTGGT CCAAGCCCCTGGCCGAGATCGATAGCATTGAGCTCATGTACGGGATCAAAGACATGCCAG GAGATCGTACCACCATCGATCTCACACACGAAGAGAACCATTACTCCATTGAGAACTTGA

AGCCGGACACCGAGTACGAGGTGGCCCTCATCTCCCGCAGGGCCGACATGTCCAGCAACC CCGACAAAGAGAACTTCACAAACAGCCTGCATGCGCCCAGAAATCTCCGCCGCATCTCCC AAACAGACACAGCATCACCTGGAGTGGAGGAACGTCAGGCAGCCGCCGACAGTAAGAAT TAATATGCTCCATCTTGGAGCGACACGCGGAGAGAAGACCCAGAACAAACACACAACAA ACACCTACAGGCTGAGGCAGAAGATTTGGTTGGGGGTGGTGAAGAGAAGGAAG

>'990928a-020.scf came from CONTIG 17 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-020.scf(35>533)

CTGAAATTTAAGGAATATAATCTATTGCTTTATTITGGCACTGGTTTGCAGCATGTGATGTT CATTTTCTGTGTACATGATATGTCCTCATCTGGATGCTAAACTCAGGAAATCAGAGAAATG

CATATGCGTTTTCTATGTTGATTTCTCCTTTTCTTAATCATGCTTGTCTTAAAAAAAATATT

ATCTAAAATTTACTGGGAACTGGATTCATAGCTGGCACCTTGTTTTTATGTAAACAGATTG

CAGATAGACCAAAGATCATCTGGACCATTTTGTGGTTCCCTGCCTGTCTTCTGATTATCGC

TCTCTCATCCATCCTTTCTCTTCTAGAA^ ATCTCTGACTTTCAGTGACTTANGGGAATAGTTACATTCCCCTGGATTANCTGNTAGCTAC

CTCCTGCATCCCTTANGGATTTTTATCTTAATTCTAATTTGTCTTCAGTTANATCCTTCTCCA

ATGT

>'990928a-023.scf came from CONTIG 18 at offset 0; "E:\SEQUENCE\export\EST_db\990928a\990928a-023.scf (35>601)

CGCCACTGAAGATCCTGGTGTCGCCATGGGCCGCCGCCCCGCCCGGGGTTACCGGGATTG TAAGAACAAGCCGCACCCAAAGTCTCGCTTCTGTCGAGGGGGCCCTGATGCTAAGATTCG CATCTTTGACTTGGGGCGTAAGAAGGCCAAAGTGGATGAGTTCCCACTCTGTGGCCACAT GGGGTGAGATGAGTATGAGCAGCTCTCCTCTGAAGCCCTGGAGGCTGCCCGTATTTGTGC CAACAAGTACATGGTGAAAAGATGTGGCAAAGATGGTTTTCACATCCGAGTGCGGCTCCA

CCCCTTCCATGTCATCCGCATCAACAAGATGTTGTGTTGTGCTGGAGCTGATAGACTCCAG ACAGGTATGCGCGGTGCCTTTGTAAAGCCCCAGGCACAGTNGGCCAGGTCCACTTGNCCC AGTCATATGTCCATCCGCACCAGCTGCAGACAAGGACATGGATTGAGCCTCCGCGGCCAG TTCAGTTCCTGCCGCACAAATCAATCTTATAATGAGATTACAAGTCACCGAGATTGAGAAT GAGAGAAAGGATATCAACGCTGGGG

>'990928a-051.scf came from CONTIG 18 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-051.scf(33>601)

CGCCACTGAAGATCCTGGTGTCGCCATGGGCCGCCGCCCCGCCCGGGGTTACCGGTATTGT AAGAACAAGCCGTACCCAAAGTCTCGCTTCTGTCGAGGTGTCCCTGATGCTAAGATTCGC

ATCTTTGACTTGGGGCGTAAGAAGGCCAAAGTGGATGAGTTCCCACTCTGTGGCCACATG GTGTCAGATGAGTATGAGCAGTTCTCCTCTGAAGCCCTGGAGGCTGCCCGTATTTGTGCCA ACAAGTACATGGTGAAAAGCTGGGCAAAGATGGTTTTCACATCCGAGTGCGGCTCCACCC CTTCCATGTCATCCGCATCAACAAGATGTTGTGTTGTGCTGAAGCTGATAGACTCCAGACA GGTATGCGCGGTGCCTTTGGAAAGCACCAGGGCACAGTGGCCAAGGTCCACATTGTCCAG

TCATTAGTCCATCCGCACCAGCTGCAGAACAGGAAATGTGATGAAGCCTCCGCGGCCAGT TCAAGTCCTGCCGCACAAATCACATTTAAATTGGGATTACAAGTCAAGCGAGAATGGAAA GTGGAGAAAAGATATCCAAGGTGGGG >'990928a-024.scf came from CONTIG 19 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-024.scf(27>564)

CTGGTGGTGCTGTCTCAGGGGCTGAAGCCCATAAGGCCCTCAGGAAAGCAGAAAGCTTGT ATATATCTCTTTGTGTCGTGGAAGCCAAAGTGAAGGCCCAGGCCGCGCCGAACAGGGACG TGCAGAGAGAGATTGCGGACCTCGGTGAGGCCTTGGCCACTGCCTTCATCCCTCANTGGC AAAATGATGAATTACGGGAGAATTTTAAGTATCTGAATAAGGTCATGGATGACCTATACC

GGGCTAGCAAAGCCGATGTGCAGAATCGGGTGTTGGAGAAGACTAATCAACTCATCGACA GCAGCCCCAACCAGCCCCTGGTCATGCTGGGAGTGGAGAGCGGCGCCTCGGCCAAGGCCT GATCGAAGCCTGTACTCTTTANATGCTTCCCCCCACACGCCGTCTGCTCTTTACATGGATA CGAGCCGCAGATACTGCTTGGTCAGTACCCACATGCAGCACGGGGCTGAGGCATGAGGGG GAGAGGGTCAGCTGTGATGCAAGAGAGGAAACGGCTGTAGCCAGCAGAGGGCTCTGT

>'990928a-026.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-026.scf(34>601)

GGAGCGAGCGCCATGGTGCTGCTGCACGTGCTTTTCGAGCACGCGGGCGGCTACGCGCTT CTGGCGCTGAAGGAGGAGGAGGAGATCAGCCTTCTGCTGCCGCAGGTGGAGGAGGGCGT GCTGAACCTGGGCAAATTCCACAACATCGTTCGTCTTGTGGCCTTTTGTCCCTTTTCCTCGT CCCAAGTTGCCTTGGAAAATGCCAACGCTGTGTCTGAAGGTGTTGTTCATGAGGACCTCCG CCTGCTCTTGGAGACTCACCTGCCACCCAAAAAGAAGAAAGTACTTCTGGGAGTTGGGGA

CCCCAAGATAGGTGCGGCTATACAAGAGGAGTTAGGGTACAACTGCCAGACTGGAGGTGT CATAGCCGAGATCCTTCGAGGAGTTCGTCTGCACTTCCACAACCTGGTGAAAGGTCTGACC GATTTGTCTGGCTGTAAAGCCCAACTGGGCTGGGACACAGCTATTCTGTGCGAAAGTTAA GTTATGTGAACCGATGGACACATGATTATCCAGTCTATANCCTCCTGGACACTGGAAAAG ATATCATACTTCTTCTGCGTGTAGG

>'990928a-027.scf came from CONTIG 21 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-027.scf(33>427)

CTTAATTCAAAGAGGGGTGGAAACGTGGAGCAGCGGAAGTCTTCCTGGGCGCCTAGATTC CCGGGAGGGAAGGAGGAGCTGACTGGGAATAATTTTTTCTCCTCACCCCCCACGCCCCCG

GATATCGCCCTCGGCACTCACCATGAAGAAAAATGAATAGAGGGGGGGCACATGGATTTC CAGTAGCCGCCGAGTGTGGGAACTCCCAGGTTTGCTTTTTATGGTTTTCTGGTGAAAAGCG GCATGTGAACAAATCCATGAACAAACCCAAGAGCTGTGAATATTCGCACAGAAGGTGCTG GGGCGGAGTGGGAGGCGGCGGCAACTAGCCTTCAGGTGGGAGGGAGAGAGAAGATCGCC CCACTGACCTTGAAGACCTCCCTGTAAGTCCCACG

>'990928a-029.scf came from CONTIG 22 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-029.scf(39>424)

GCACGAGGCTCTTTCTGTAAAAGGTGCAGAGGTGGCATCAATGACGATGAATGTGATCCA CACTGTGCCTAACTTGGATTGGCTTTCTGTGTGGATCAAAGCCTATGCTTTTGTGCATGTTG

GTGACAATTCGAGAGCAATCAATACCATTTGTTCACTANAGAAAAAGTCCTTGTTGAGAG ATAACGCGGGACCTACTGGGAAGCTTAGCAGATCTGTACTTCAGAGCTGGAGACAATAAG AACTCTGTCCTCAAGTTTGAACAGCACAGAGTTGGATCCATATCTAATAAAGGAATGATG TGTATGGCTATCTCCCTGCAGAGAAGACGATGGAGNAGNNGGAGACCTTGCTGCCGCCTT TTATATATCTGACCACAGCACACC

>'990928a-030.scf came from CONTIG 23 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-030.scf(39>593)

GCACGAGGCGGAGACGCGAGGAGCAGGAGGCTCGGGAGAAGGCGCAGGCCGAGCAGAG GAGCAGGAGCGGCTGCAGAAGCAAAAAGAGGAGGCCGAAGCTCGGTGCCCGAGAAGAA

GCAGAGCGGGAGCGTCTGGAGCGGGAAAAGCACTTCCAGCGGGAGGAGCAGGAGCGGCA AGAGCGTATAAAGCGCTTGGAGGAGATTATGAAGAGGACTCGGAAGTCAGAAACTGCTG AAACCAACAAGCAGGACAGAAGGAGGCGACGGCCAACAATTCCAGCCCACGGATAGACC CTGCGAAAGCTGTGGAGGGTCGGCCTGCCGGGCTGCAGATGAGGAGCTGGGCCCCCAGA GCCTCATGGGAGCCTGCCAACAAGAAGTCGCTGGGTCCCTGGTGATGGGCTGCAGCTTGC

CACGCACCAGATAACGGTTNTCTCTATGGACCCTCNGACAAGAGTGGCNCGACGCACAGC TCTCTGCCTTCCAAGCATAACTATTATAAATTGGTGCAGCCCTAGCCATAATCTTAGGTTG CTGTTCAGCCAGTATAGCTCTT >'990928a-031.scf came from CONTIG 24 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-031.scf (34>418)

TTTCAGAGATGGAGGCAAACATGAAGGGAAAGACATGTAATGAAGATTTTTTTI ΓT^ ATCGTGGTCTTTTTTTTTT CCAAAGCA^

GGAAAGCGGGAAAATCACATCTCACATTTTTGTACCTTCCCGTGTATGCGTCGGGGTTCGG CGTCTGCATCACCAACGCGGAAGGTGGGCCATCAGGCGGCTCGTTCTTTGGGGTAGGGGA

GGGGCGGAGAACCAAGATTTTGCATCAAGCTCTGGATCCTGACGGGGTTGTATGTTGGGA CTCTGAGTTGGGGAATAGTCACAACACTGCCAGAACTGGATAGGGACCTCGATTGAAAGG ACACAGCTACTGCTTCCACTT >'990928a-032.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-032.scf(39>446)

GCACGAGGCCCAGGCGGGAAGGCGTGGAGGCTCCTGTGGTAGCCCTCCTGAGCTGTGCTG GAAGCCTGGACTGACCAATCACCCAATCCCAGTTCTTCCTGCAAAACTCTGTGGCCAGCCT GGCATCAGTTCAGGCCTCTGCTGGGGGGAGGGGGGCCAGGCCTGGTTGTCTAAATGCAGG

CAGCTGGCAGAGGGGGGGTGGGTATGTTTCCATGGTTACCATGGGTGTGGAGAGAAGTTG GGGCCCCTACTCTCCCAGCTGAGCGGCCCTGCGGCTTCAGTGCATGCATTGATGCGTNTCT GTCCTGAGGCTCATCTGTGTGTGTGTTTGTGGTTTAAAATACTATGTTTGCCCCTCCTCACA AAAAATGCACTTGTATATTCCCTTTAGTGAAAATGGTAAGGGAT

>'990928a-035.scf came from CONTIG 26 at offset 0;Ε:\SEQUENCE\export\EST_db\990928a\990928a-035.scf(39>316)

GCACGAGGCTTAACCCACTGGGTTTATAAGAAGTATCCAAACGTGTTTAAGAAGATCCGA GGCATTGTGGAAGAGAGCGTGACTGGGGTTCACAGGCTGTATCAGCTCTCCAAAGCTGGG AAGCTCTGTGTTCCGGCCATGAACGTCAATGATTTTGTTACCAAACAGAAGTTTGATAACT

TATACTGCTGCCGAGAATCCATTTTGGATGGCCTGAAGAGGACCACAGATGTAATGTTTG GTGGGAAACAAGGGTAGTGTGTGGGTTGTGGAAGGGG

>'990928a-036.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-036.scf(39>557)

GCACGAGGGCGCACTGCGCCCGGCCCAGCTTCTTTCAAAATGTCTACCGTTCATGAAATTC TGTGCAAGCTCAGTTTGGAGGGTGATCACTCCACACCTCCAATGCATACGGGTCAGTCAA AGCGTACACTAACTTTGATGCTGAGCGGGATGCTCTGAACATTGAAACAGACATCAAGAC CAAAGGTGTGGATGAGGTCACCATCGTCAACATCCTGACCAACCGCAGCAATGAACAGAG ACAGGATATTGCCTTCGCCTACCACAAAAGGACCAAGAAGGAACTTGCATCAGCACTGAA

GTCAGGCTTGTCTGGCCACCTGAGACAGTGATTNTGGNCCTATTGTAAATACTGCTCATAT GATGCTTCTGACTGAAAGCGTCATAAGGGGCTGGGACTGATGAGACTTCTATTGGAACAT CTGCTCAGGACAACCAGACTGCAGAATCACAGAGTTTAAGAAAGTACAAACGATTGGAA AGAATTGNTTCGAACATTGGGATTCGCAGTGAGGCGCC

>'990928a-037.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-037.scf(39>565)

GCACGAGGATATTCCATTTTGCATTTTCCCCCTACCCCCAAGAAAAAGAAATGCAAAAAG GCAAAATGGTTGTTTGAGGAGGTTTTACAAATAGATGAGAAAAGAAGAGAAGCGAAAAG CAAAGGAGAAAAGGAAAGATACATCCATCTGAATGCAGAGTTCCAAACAATATCAAGCA

GAGATTTAAAAAAGCCTTCCTAAGTGAACAATGCCAACAAAGGTCCATCTATTCAAAGCT GTGGTTTTTCCAGTAGTCGGGTATGGATGTGAGAGTTGGAGTATAAAGAAAGCTGAGCGC CAAAGAATTGATGCTTTTGAACTGTGGTGTTGTTGAAGACTCTTGTNATCCCTTGGACTGC NAGGAATCACATCATATCATTCTAAGNAAANACTCCTGCATATTCCTGGAGGACTGAGTT GAAGCTGAACTCCATACTTTGCCTCTGATGCAACACTGACTCATGAAGACGTGATGTGGG

AGATGCAGNAGAGAGAGGGAGAAGAGATCAAGGTGGATGCTCCTGCTC

>'990928a-053.scf came from CONTIG 28 at offset 0;Ε:\SEQUENCE\export\EST_db\990928a\990928a-053.scf(39>582) GCACGAGGATATTCCATTTTGCATTTTCCCCCTACCCCCAAAAAAAAGAAATGCAAAAAG

GCAAAATGGTTGTTTGAGGAGGTTTTACAAATAGATGAGAAAAGAAGAGAAGCGAAAAG CAAAGGAGAAAAGGAAAGATACATCCATCTGAATGCAGAGTTCCAAACAATATCAAGCA GAGATTTAAAAAAGCCTTCCTAAGTGAACAATGCCAACAAAGGTCCATCTAGTCAAAGCT GTGGTTTTTCCAGTAGTCGGGTATGGATGTGAGATTGGAGTATATAGAAAGCTGAGCGCC AAAGATTGATGCTTTTGACTGTGNGNTGTTGAAGACTCTGAGAGTCCCTTGACTGCCAGAA

TCAATCATTCTTCTAAAGAATCAGTCTGATATTCCTGGAAGACGAGTTGAAGCGAACTCAT ACTTGCCTCTGAGCAAGACTGATCATTGAAAACTGATGTGGAGATGCAGAGAGAGAGGAG ACGAGACAAGGTGATGCTCCTGCTCCTGAGATTGGAATCAGGTGGAGGACGGACGCTGTG GGCG

>'990928a-038.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-038.scf(33>524)

TGGATGTGCAAAATTATTCTTCCATACTGAGTATGAGAAAACAACTCCCAGAGGAAACCT TATGGATATAAAGAGGGTGGGAAGACCCTCAGGCAAAAGAAGGTCTTAGTCTACATCAGA GAATTAAAAATGGAGAGAAACCCTTTGAATGTACTGCCTGTAGGAAAACTTTCAGCAAGA AGTCACACCTCATTGTACACTGGAGAACTCATACAGGAGAGAAACCCTTTGGATGTACAG AATGTGGAAAAGCTTTTAGCCAAAAATCTCAGCTCATTATACACCTGAGAACTCATACAG GAGAGCGACCCTTTGAGTGTCCAGAAGTGGGAAAAGCTTTCAGAGAAAAATCTACTGTCA TTATACATTACAGGACTCATACAGCAGAGAAACCTATGAATGTATGGAAGNNGGAAAGCC

TTCACTCAAAGTCAAACTCATGTCCATCACAAACCCCACAGAGAAAAACTATGATGCCCA ATGGGGGATCTT

>'990928a-039.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export EST_db\990928a\990928a-039.scf(33>543)

CGGCGGCGGCTCCCGTCGGCCTTCTGCAAGACTGACCGTAGGGAGGCCGGAAAGCGGGCG CGCGCGGCGGACAGGCGGGCGGGAGGCCGGAGCTTATTGAATGAAAACTGCCAGAGACT GAAAAACCAAACATGAGGGGAGCAGGTGCTGCAAAGTTGGGGGTCGCTGTGGCAGTATTT TTACTGACATTCTATGTTATTTCTCAAGTATTCGAAATAAAAATGGATGCAAGTTTAAGAA ATCTATTTGCAAGGTCAGCATTGGATGCGGTTGTACGTTCTACAAAACCTCCCAGATATAA

ATGTGGAΛTCTCAAAATCTTGCCCTGAGAAGCATTTTGCTTTTAAAATGGCAGTGGAGCAG CCATGTGGGGGGACCCAAATCTGCCTAGAGACATGTTTTATGAGTGGTGTAAAAATAGTT GAAANAGAATCAAGNTGCCTGGTAATGGCAAAACGAAGACTAAAACACCAATTTTGACT GGGGGGGNAAGGGCCCTTTTTATTCTAAGC

>'990928a-041.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-041.scf(39>575)

GCACGAGGCGGGCCTTCTGAGCATACTTTATTTCCGCTCTACTTGCTGCCTGCTGCTTACTC ATCCTGATAGTACCACTATCTTTTAAACTCCTAACATATAAAGGGATAAACAAAAATGATT TGTGGGGATGGAGAGAAGAATAGGATGATGGCACTTAGTAAACTCGATGTATACCCAGTA

TATCATTTATCATTTGCTGGGTAACAAATAACCCCCTCAAATGTAGTGGCTTCAACACCAT TTATTTATCTCATGATTCAAAGTCAGTAGTTTGAGTTGAGTTCAGTTGGGCGGTTTTTCTGC TCGTGGTTGGGCTCACTCTATGGTCAGTTGCTAGGCAGGGGGATGGCTAGTGTCTAGAGTA GACTTAACCAAATGACTATCTCTGTTTCACATGTTCTGTCTATATTCACTAGCCACCTGGGC TGTTGACTATAGCTGCATGATACAGGAGGATAGAGGACCCCACCTATCCTCTCTGAGCCTG

CCCTGCGATGAGCTAGAGTTTTTTTGATAACAATAGAAGGAAACTGA

>'990928a-042.scf came from CONTIG 32 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-042.scf(39>470) GCACGAGGATCCATGGGCACTATGCAAAAATCGGCACCGTCCTGACCTTCTTTTGTAACA

GCTCCTATGTTCTCAGTGGTAATGAGATGAGAACTTGCCAGCAAAAGGAGAGTGGTCAGG GAAACAGCCAATCTGCATAAAAGCCTGCCGAGAACCAAAAATCTCAGACCTGGTGAGAC GGAAAGTTCTTCCAATGCAGGTTCAGTCAAGGGAGACGCCATTACATCAGCTATACTCAT CAACCTTCAACAAGCAGAAACTGCAGTATGCCCCTACCAAGAATCCAGTCCTTCCCTTTGT AGACCTGCCGCCTGNGTACCAACATCTGCACACCCACTCATACGAGTGCATCTCACCTTTA

TCNGCGCTGGCAGCACCGGAGACGGTCTAAGATGNGAGGGAGGGGCGGGCCCATCTGCT NCTATTGTGGAA

>'990928a-044.scf came from CONTIG 33 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-044.scf(39>566)

GCACGAGGGGAAGCCCTCTTCTTTGTTGGTTATCCATCTTAAATGTAGCAGTGTGCACATG TCAGTCCCAAACTCCCTAACTATCCCTCCCCCAAATCAGAATTTTAGTTAGGAATGGGAAT TCCTGTAGTTACATAGAAACTTAGAGAGAGGCAGCTTGTTGAAGGTTATAGAACTATGCA GCTAGTCACAGAGCTAAAACCACAGAAAGGTATCTCTATTCCTTTTTCCTGTTTATACTCT ATCAGATTGCATATTTACCTTATGGAGGAAAAAAACAGATTTAAGAAATCTGTTTATGGC

ACCAATATTTTTTC1TTCAAGCTTTGTCTTTCCAGCACCAAACGTTAGATGTAATACACAA GCACACATACTGTGTGTGTGGGTGTGTGCATTTGTGCATGTGGATTTTTACAAAAGTTNTT ATTGAAAAGCAAGAAATATATAGCACTGATACCTCTTTCTGGACACAGATACTGGTTTCTT AACATATCACCTCCCCTCTCCAAAAAAATTTCAGCAGNAAAC

>'990928a-046.scf came from CONTIG 34 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-046.scf(39>526)

GCACGAGGCTCTCCTTACCTAAGTCCAGATTTGTTTTTAAGGCATAGAATGTATAGCAACC CACCCAGTTCCAATCTGACTGATTTTTCCAGACAAGAAACAAGCAAACTGACCATGGATG GCTGGAGGGCATCGACACCGACTGCAGGATACACGATGCCGCAAACAGGCAGCAGCCTCT TCATACGAGTGTCCAGCTACTCCCTGGCTTCCCCACTGTTGTATAAAGAAGGATTTGGCTG GTCTTTGTTGCCACTTCCTAAGAGGAACCTATAAACTTTCATAACTTCCTTGGTGATAGGA GTGTCTTTGTTATTCATGGTGGACCCTTTGGATCTCAACTTTTTACTTAACGAGGTGACTCA TGGTGGGCCCTANATAGTTTCAGGATGGGCTGGGTGTGGCTGAGAGATCAACCATGAGAT

ACAAAGCTGGGCCCTGAGTATCTGCTTCTGACATCTGGGTGGGAGAGAGAAAGGGAAATG AGN

>'990928a-047.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-047.scf(33>617)

TTTTTGTTTATTTTTTCAATTTTTAAAAAACAAAT^^

ATCCCAAAGCAGATAAGCTTAACACGTTAGGGTTAACAGGAGAGAAAGGGGTTAAGTCA

CACACGACTTGGGGGTTGGGGGGTGACGCGGCCGGAACCCGGGGGGGGGCACGGTTGCT TATCGCCCCAAATAAATAAACACGGGGCCCTCCCCTCAGGGAGAGGAGGGGGAAGGGAA

GCACGACGGCTGGACAAACATGCGCGTTATGCCAAAACCTGGCTTAAAAAAAAAGAAAA CCCACAAGCAGGAACGCTCAGGACACCTGTGAGTAGGGTGGGCAGGAGGGGATCGGCCA AAAGCCAAACCACCGAACCCGGGGGCCTGGGCCCCCACCTGCCTCACAGATGCGGGACCC CACCCTGGCTTTCGAATAAGGAGCTAGGGGGACACACCCACCCTAGGCCATCCCAGGAGG CCCAGCTTGCAGCCCCGCCCCGGGTCCCCGCCATTGGAGCGGGGG

>'990928a-049.scf came from CONTIG 36 at offset

0;Ε:\SEQUENCE\export\EST_db\990928a\990928a-049.scf(26>628)

CTGTTTAATTCGGCACGAGGCTCAGCTGCAGCCCGCACCGTTGCCGCCTGGTACCGGGTTG GGAACAGGAGCCTAGGGGTGCTTGCAGCAGGCCGTCCCGGGCAGCAAGGTGGGGGGCCC

TACAGCGATGCTCCGAGGCATGTACCTCACTCGGAATGGGAACCTCCAGAGGCGGCACAC CATGAAGGAAGCCAAGGACATGAAGAACAAGCTGGGCATCTTTAGGCGGCGGAACGAAT CGCCTGGGGCCCAGCCAACGGGCAAGACAGACAAAGTGATGAAGTCATTCAAGCCCACTT CAGATGAAGCGCTCAAGTGGGCGAGTCCTTTGAGAGCTACTGGTCCACAATACGGTCTAG CGGTGTTCCATGCCTTCCTCCGACTGAGTTTATGAGGAGAACTGGATTCTGCTGGATGCGA

GACTTCAGAAGNNCAGCACAGCCAGATGCGCCAAGCANAAAACTTGCTGGACATCGCATC AGCGGCAGGAGAAACTGACTGNAACAGGACAACAAGACACTANANGTACTCGGCTGTTG ACTCACAATGCATTGGTATGTGAGATCTACCCCTCTCCTGCCTTCTGACTTACAAAAAAAA CCC

>'990928a-050.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-050.scf(42>608)

GCACGAGGCTCGCTTCTCCCGGCCGCATCCCGCGGGACCGGAGCGAGCAGCGGGGACCAT GTTCCGACGCAAGTTGACGGCCCTTGACTACCACAATCCTGCCGGCTTCAACTGCAAAGAT GAAACAGAATTTAGGAACTTCATTGTTTGGCTTGAAGACCAGAAAATCAGACACTATAAA

ATTGAAGACAGAGGTAATTTAAGAAACATCCACAGCAGTGACTGGCCCAAGTTCTTTGAA AAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAGATCGACAGGAAGCAATCGAC TGGCTTCTTGGCTTAACTGTTAGACTTGAGTATGGAGATAATGCTGAAAAATACAACAAG GACTTGGTACCTGATAATACAAAAAATGCTGACAATGCAGCTAAAATGCAGACCATTGAT CATTTGGATGTAAATATCCTGATTTAAAGGCTGTGTATGTCTTGGCTACCTTCTCAATCCAC

GTATGATGATACTGNAAGCTAAGCATTGCATTTGTCCAGACGCCGACCAGAGCATGCTAG CAATAATGAGAGGTGCTGTGCTAA

>'990928a-052.scf came from CONTIG 38 at offset 0;Ε:\SEQUENCE\export\EST_db\990928a\990928a-052.scf(34>527)

CACCGCCGGGGGGAGAGGAGGGGAGCCTGTCCGAGCCCCGGCCCCAAGTAACGCCGCCG CCCCGGAGCCGCCTTGGAGTCCTCCTCCCCACTAATTGCCTCTTTGCATAGCACCGGCCCC TGCCCCCACGCTCACTGGTACCACTACAGCGGGACGGGCCATGGCGGGGCGGGGAGGCGC AGCGCGACCCAACGGACCAGCTGCTGGGAACAAGATCTGTCAGTTTAATCTGGTCCTGCT GGGGGGAGTCCGCAGTGGGCAAATCCAGCCTCGTCCTCCGCTTCGTCAAGGGTCAGTTCC

ACGAATACCAAGAATAGCACATTGGAGCGGCCTTCCTCACACAGACCGTCTGCTTGGAGA CACACAGTCAAATTGAGATCTGGGACACAATGGACAGACGGATCACACCTGCCCCCTGTA TATCGGGGGCCCAGCTGCTCGGGGGCTACACATCACACACAAACCTTGACGGCAGACTGA GAAGANGTAAGAGN >'990928a-055.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-055.scf (31>112)

TTTTTATATCACAATCAATAGATTTACCAACAACCGGGAGCTGCAACTGCCTCTTTGAATG GGGGTGGGGTGGGGGAGNAGG

>'990928a-056.scf came from CONTIG 40 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-056.scf(26>376)

CTGCTGGCCATACCTCTTAATAATACTTGATTTTTATACATTCACATGTTTTAAATGCTCAA GTTTGTAGAAGACACTAGGAGAATTCCATTCCATTTCCTGGATGGTTGCTGCTCTGGCTTT

TTAAAACTTGGAACTAACGTTTATTTAAAGCAAAGAAAAATCTTTTAAGAGGCTAAATTG ATGCTGCTATTATTGCTGTGAAATTGTATAAAGATTAGGATTCATGCCAGTTTTTTTAAATC TAAAAAATCATGTGATTGCATTTAAGGGTTTATATTTAAAAAAAGAAATAAAGTTTTAAG AGCAACACATTTACTTATTATATATGTGGAAATACTTGTTANGTGT

>'990928a-057.scf came from CONTIG 41 at offset 0;"E:\SEQUENCE\export\EST _db\990928a\990928a-057.scf(26>601)

CTGCTTGCGGACCTGCTGGAGCTCCTGGCACTCCTGGACCTCAAGGTATTGCTGGACAGCG TGGGGTGGTCGGCCTGCCTGGGCAGAGAGGAGAAAGAGGCTTCCCTGGTCTTCCTGGGCC CCTCTGGGGAACCCGGCAAACAAGGTCCTTCTGGAGCAAGGGGTGAACGCGGCCCCCCTG

GTCCCATGGGCCCCCCTGGATTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTC CTGGGGCTGAAGGATCCCACTGACGATATGGTTCTCCTGGCGCCAAGGGTGACCGNGGNG AGACCGGCCCTGCTGGACCTCCTGGTGCTCCCTGCGCTCCCCGGGCCCCCGCCCCTGTCGG ACCTGCCGGCAGACGGGNGATCGNGGNGAGACCCGTCTGCTGGTCTGCTGGTCCATTGCC CGGTGTGGCCGNGGCCCCCNTGACCCAGCCCCGAGNGACAGGGGAGAAGGGACAGGCGA

AAGATAGGGCACGGGGTTTTGTTCCAGCCCCCCGCCTCGCTTCTGGAGATGACTCGAGCTT GTCTTGTGCCCCGCCCGCTTGTGTTTCGAATTGA

>'990928a-058.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST _db\990928a\990928a-058.scf(26>628)

CTGCTTTAATTCGGCACGAGGCAGTGACATTGTGCCCACATGGGACGGTATTCGGATGGG GGAGAGACTCCGCACCATGTCCTGCAGCGACAAGATCCTGCGCTGGAACGTGCTGGGGCC TGCAGGGGGCACTGTTGACCCACTTCCTGGAGCCTGTGTATCTCAAATCCGTCACTCTGGG TTACCTATTCAGCCAGGGGCACCTGACCCGCGCCATTTGCTGTCGTGTGACAAGAGATGG AAGAGCGTTTGAGGATGGACTTCGACATCCCTTTATTGTCAACCACCCCAAGGTTGGCCGA

GTAAGAGTATACAAATCCAAAAGGCAAGATGGGAGACCAAGAGAAAAGGTCAACTGGTG TTTGGGTGATGCTACGACTCGAAATCTGGATGGACAGAGCACCGGGAGGACCACGGACGA ATGTCCGGAGAACAAAAGACATTTTCTTATTAAGAGCTTGTCTTCGATCCGAAAAATATTA ATCTCTAGGGAGCAAAAAGTCCGGATACAAAACAAACTATTAAAATTTGAGAAGGCTAGG AAGGTACAGCCAGAGAAAATTTACTGCGGGTGGCGGGTGGGGGGGTTCAGGGGGAAAGG

GG

>'990928a-059.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-059.scf(34>633) TTCAGAATGAAGCTGAACATCTCTTTCCCGGCCACTGGCTGCCAGAAGCTCATTGAAGGG

GACGATGAACGAAAACTTCGTACCTTCTACGAGAAGCGTATGGCCACAGAAGGTGCTGCT GACGCTCTGGGGGAAGAATGGAAGGGTTATGTGGTCCGAATCAGAGGCGGGAACGATAA GCAGGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCAGAGTTCGCCTGCTACTGAGT AAGGGGCATTCCTGTTACAGACCAAGGAGGACTGAAGAGAGAAAGCGCAAATCTGTACG GGGTTGCATTGTGGATGCCAATCTGAGTGTTCTCATTTGGTCATCAGGAAAAAAGGGATA

AGGATATTCCTGGACTCACTGATACTACAGGCCCTGTGCCTGGGTCCCAAAGACCAGCAA ATCCGCAACTTTCATCTCTTATGAANAGATGCCGCATATGTGGGGAAGCCCTAACAAACG TAGAAACTAGACTAAGCACAGATCACGCCTGGACTCCGANTTGCACCAAGCGCGGTTGTT GAGATAGGATATAAAAAGAGAGTGGAATGTACTTGTAGAAGAGAGCAGAAAGAGAAGAG CA

>'990928a-062.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-062.scf(26>467) CTCTTCACACCGGGGCAAGAGTTTGCATGATTAATAAGAAGCAGTTTTTTCATGAAATGCT TGGAGGGGAACGAGTTCTCAGCCTGTGAGATCCGACCATCCCATTGACTTTGAAATTTCTT TTGATTAATATAAAGAAAAAGTGGGGAGGGGAGAAGAGGAGGAACATGCTAGCGACTGA AAGATCTCTGGTGACAGCCATCCAAATGTGAAAAAAGAAAACAGAAAACCCAAAAGAAA

ACCAATTTGCCACCTGCCCTTTTCTGTTTTACCACGCTCTGCTCCTCGCTCTTGTTTTTGTCT TTCTGGTTGAAACAGCCTCCCTGCCCTGCATCTCCTAAAGAAGTTTGGAGGGGAGCACCCC TGCCGACCGGGGACC >'990928a-063.scf came from CONTIG 45 at offset

0;"E:\SEQUENCE\exρort\EST_db\990928a\990928a-063.scf(33>412)

TTTTTTTTTGGTAAGGTTGAATGCACπ

AAAACTAAGTTTGAGAGATGAATGCAAAGGAAAAAAATATTTTCCAAAGTCCATGTGAAA

TTGTCTCCCATTTTTTGGCTTTTCGGGGGTTTCAGTTTGGGTTGTπ AGGGGCAAGTGGGTTGGGTGGGAGGGAGCCAGGTTGGGGTGGAAGGAGTTTACAGGAAG

CAGGCAGGGCCAACGTCGAAGCCGAATTCCTGGTCTGNGGCGCCAACGTCCAAGGGGGCC

ACATCGATGATGGGCAAGCGGGAGGTCTTGTTGTTTTTGTATTCGATCACTGTCTTGCCCC

ACGCTCCGTGTGACT >'990928a-064.scf came from CONTIG 46 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-064.scf(27>552)

TGCAGGTTCGCTTAGGGGCAGACGGGCAAACAGAGCCAGCATGCCGGTCGCCCGGAGGT GGGTTTGTCGCAAAACCTATGTGACCCCGCGGAGACCCTTCGAGAAGTCCCGCCTCGACC AAGAGCTGAAGCTGATCGGCGAGTATGGGCTCCGGAACAAACGTGAGGTCTGGAGGGTC AAATTCACCCTGGCCAAGATCCGAAAGGCTGCCCGGGAGCTGCTGACGCTGGATGAGAAA

GACCCGCGGCGTCTGTTCGAAGGTAATGCCCTGTTGCGGCGGGTCGTCCGTATCGGGGTG CTGGATGAGGGCANGATGAAGCTGGATTACATCCTGNGCCTGAAATTGAGGATTTNTTGG AGAGACGCCTGCAGACCCANGTCTTCAAGCTGGGCCTGCNCAAGTCCATCCACCAGCCCG TGTGCTCATCCGCCACGCCACATCAGGTCCGAGCAAGGGGGGACATCCCGTCTTCTCGGC GCCTGACTCGCAAAACAATCGACTCTCCTGCCTCCCTCGCGGGGCCGC

>'990928a-068.scf came from CONTIG 47 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-068.scf(34>622)

GTTGGATTTATTATTAAATTTTATTATGGATGCACGTACAAAAAAATGAAGAATAACGAC ACACAACACTATGGAGAATAATTTAAACAAATTTTCTGTGATAATGAAACCAAAGCCGCC

ACTTTATTTATTGTTTGTTGTGGATGATTTTATAAGGATGGAGGGGATGAGGATTCTGGAG

CGGTAATCGAGCATGCTTGTTTTTTATAAAACAAAATCTAACGGAGGACCTGGAATTAGA

TTGCAAGTCAATATTTTTGTTCTAGAGTTATCATAGCGAAAGACCATATGACCAAACCATG

GTATTTATTGACTTGACTAATATTGAAAAAATGGACCAGGACCAACCAAGAATAAGAAAT ATTGCTTTACAACAAATGAATTCAAAATTTATTTC

TCGTATGTTTTTTTTAAAAAAATTCAGAATGTACGT^

TTTCAAAATTTGTGCTTTCATAAAGAGACTTGTTCGAAAGCTTCTTATTTTGTTGAGTTTGT

TAAGTCTTATTTGGGAACAATGTTTTGAATGGTAATAAAA >'990928a-077.scf came from CONTIG 48 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-077.scf(39>465)

GCACGAGGCCGAAGACGTCCTCGATGTCCAGCTGGCATTCCTCCGACTTCTCTCCAGCCGG GCCTCTCAGAACATCACATATCACTGCAAGAATAGCATTGCATACATGGATCATGCCAGT GGGAATGTAAAGAAAGCCTTGAAGCTGATGGGGATCAAATGAAGGTGAATTCAAGGCTG AAGGAAATAGCAAATTCACATACACAGTTCTGGAGGATGGTTGCACAAAACACACTGGGG

AATGGGGCAAAACAGTCTTCCAGTATCAAACACGCAGGGCCGTCAGACTACCTATTGTAG ATATTGCACCTTAGTATCGGGGGTCCTGATCAAGATTTGGTGCGGACATTGGGCCTGTTTG GTTTTTTTATACAAACTCTTCCAAGACC^ TGTC

>'990928a-069.scf came from CONTIG 48 at offset 164;"E:\SEQUENCE\export\EST_db\990928a\990928a-069.scf(34>497)

GGTGAATTCAAGGTTGAAGGAAATATTAAATTCACATACACAGTTGTGGAGGATGGTTGA ACAAAACACACTGGGGAATGGGGGAAAACAGTCTTCCAGTATCAAACACGCAAGGACGA CATACTACCTATTGTTGATATTGCACCCTATGATATATGGGGGCCTGATCAAGAATTTGGT GGGGACATΓGGGCCTGTTTGCTTTTTATATACCAAACTCTATCCTAAGTCCCAGAAAAAGC TTCACACTCCATATGTTGCTTTTGTTCTAATCTTGTCAGCCAGGACAAGCGACCAAGTTCC AGTTATTTATTTCCAAAATTCTTGGGAAAAAGNGCAATTTGACCAAAAAGATATTTGTT^ GCTATTACCCCAATACAGTCAGAGCTTATTGTTTATTTTTTTCCATTTCAATTCAAAAGCCT

CATGCTGCTATAATAAAAAACTCACACTCTCCATACACT

>'990928a-070.scf came from CONTIG 49 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-070.scf(34>475) CGCGAGTGGCATATTGGTTGCTACCTTGCAGGCCTGTGCACCCTGGAACCTGCCCTAGAAC

TTTGTGTGCTGGACTTGGGGAGGAGGAATCCTGGGGCTGGATACGTTCCTTCTAAAAACTT CCCCCTTCAAGTGCAAGAGCGGCATCTGGATCATTGAGGAGTGTGAGGGCAGGTTTCTGG CTCACAGGGACCTGCCGCACACATACCTGAGAATCAATCGCTTGCTCCTGTGCCATCTAGA GAGGTGTGGACACCTGATGACTGTGGAGACACCACCAGGGGGAACGTAGCATTGTTACTG GCTGACTCCAGCAAGTCTGCGCATGGAGCTGCTGATGCCCCCTTTCACTATCCTCCGGTCT

TCACCTTCCCACGTATGAGATGACTACCCTCTATATATAAACGNTATGANGCCACCTGCCT ACTCCCCTCCCACACAC

>'990928a-072.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-072.scf(34>259)

GGTGAGCGTGTATGGGGGTGCCCAGTCCCAGGAGAGAGGGGACAGAGAAGGACAGGCCT GTAGTCATTAGGATGGGCCTTCGTGCTGAGTAGCAATGTGTATACCATTTGGGCTATCAGA GGTACCCCTGGGCAGGAGCCTCCACACACCCCCTTCCCTCTTCTCTCTCCATGACTCTTCTT CACATCCTATCTTCTTCTAAGAGGGGGAGGGTAGGGGAAAATTT

>'990928a-075.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-075.scf(34>577)

CACGGAAGACTGGGAGTCTGTTCTGGGGCCAGAAGATCCGGGCAGGTGTCCAGCCAACAG CTGACCGCAGACTGCGTCTTGTCTCCGTTTCCGCAGGCACCATGAGCCAGAACACCGAGG TGGGCATGAAGGAAGTGGAACTGAACGAGCTGGAACCCGAGAAGCAGCCGATGAACGCG

GCGTGTGGGGCGGGGATGGCCGTGGTGGTGGGGGGCGGCACCGAGAAGAATGGTCTGGT TAAGATCAAGGTGGGCGACGACGAGACGGACGCAGCGGCCGAGGCCAAGCTCACGGGCC TGTCTAAAGAGGAACTGTGAAGGTGGGGGGCAGCCCCGCCTGGGTACGCACCCGCTGGGC GCTGCTGCTGGTCTTCTGGTTGGGTGGTGGGCTGCTGGCGCGCCCGGGTCATCATTTGCAG CGCCACCCTGCGCGAGCTGCTACAGAATGAGGGCAAGGGGCCTCTACGCATTGAACCTCG

GCCTCCTGGCCAGAGCAGCAACTACGACCTAAGAAGGAGGATACTAACCCTGAGGAGGTT TGGTGG

>'990928a-079.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-079.scf(34>357)

TCTTGAAGATCITΓΓTΓGTGCAGTTCTTCTGTGTATTCTTGCCACCTCI CΓΓAATATCTTCT GCTTCTATTAGGTCCATACCATTTCTGTCCTTTATCGAGCCCATCTTTGCATGAAATGTTCC CTTGGTATCTCTAATTTTCTTGAAAAGATCTCTAGTCTTTCCCATTCTGTTGTTTTCCTATAT TTCTTTGTATTGATCTCTGAGGAAGGCTTTCTTATCTCTTCTTGCTATTCTTTGGAACTCTGC ATTCAGATGCTTATATCTTTTCTTΠ^

TGTTAGGCC

>'990928a-083.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-083.scf (41>427) GCACGAGGAAACCGTGGTGAACCGGGTCCTGCCGGTGCTGTTGGTCCTGCTGGTGCTGTT

GGCCCAAGAGGTCCCAGTGGCCCACAAGGTATTCGAGGTGACAAGGGAGAGCCTGGTGA TAAGGGTCCCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGGTTGCAAGGTCTCCCGGG TCTTGCTGGTCATCATGGCGATCAAGGTGCTCCCGGTGCTGTGGGGTCCCGCTGGTCCCAG GGGCCCTGCTGGTCCTTCTGGCCCCGCTGGCAAAGACGGCGCATGGACACCTNNNNGCAG TGGACTGCTGGCATTCGTGCTCTCANGGTAGCCAAGTCCTGCTGGCCTCCTGTCCCCCTGC

CCTTCTGGACTCTGCCAGGNGGGGGG

>'990928a-084.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-084.scf(36>436) GCCGGTCTGGAGGAACTGGGGTCGACCTGAGTTCTGGGGGTGTGGTAGGCCAGGGCGGGG TGTGGCCTCCCTCCAGGCGCCATCATGATCATATACCGGGGACCTCATTAGGGCATGACG AGATGGTTTCCGACATCTACAAGATCCGGGAGGTAGGGGGCGGGGTGGGGGTGGAGGGG GAGGGGAAGATGGTCAGTAGGACAGAGGGTAACATCGATGACTGGCTCATTGGTGGAAA TGCCTCCGCTGAAGGCCCCGAGGGCGAAGGTACCGAAAGCACAGAAATCACTGGTGTCGA

TATTGTGATGAACCATCACTTGCAGGAAACCAGCTTTACAAAAGAAGACTACACTAAGTA CATCAAAGATTACATGAAGCCTATCAAAGGGAAACTTGAAGAC

>'990928a-085.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-085.scf(41>633)

GCACGAGGGCTATCCTAATCGCAATTGGAAGGATGCAGGGCTGAAGAACGGTGTACCAGC TGTGGGCCTGAAGCTTAATGACCTCATCCAACGGTTGCAGCTGTGCTACCAGCTCACCACA GTTGGCAAGTTTGAGGAGGCTGTGGAAAAATTCCGGTCCATTTTACTCAGCGTGCCACTTC TTGTTGTAGACAATAAACAAGAGATTGCAGAGGCTCAGCAGCTTATCACCATTTGCCGTG AGTACATTGTGGGTTTGTCCATGGAGACAGAAAGGAAGAAACTGCCCAAGGAAACTCTAG

ACAGCAGAGCGCATCTGTGAGATGGCAGCCTATTTCACCCACTCAAACCTGCAGCCAGTG CCATGATCCTGTGTTGCGTACAGCCCTCACCTCTTCTTCAGCTCAAGACTCAGNATGCTGC CGCCTTGCTCGCGCCTGTTGGACTCGGCCCCAGCGGAGGGATCACAACCGCAAACCTGTT GCTGGAGAAAACCAANAGCCATAATCATATACATGACACCTTGAATTGGCTGTCTTCGCC CTTACGGAAGCAGGAGAAGACGTAGGGGCTGTTTCTGTTAGTAGATGAGA

>'990928a-087.scf came from CONTIG 56 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-087.scf(35>492)

TTTTTTTTGAAAGAAACATCGCTTTTTTTATTTπ TTCTATAAAAATTCCCAATAAGAGCTAAAGAAAACCCTTTGTGTATTTGGTTTTACATATT

AATTACTCTAAAAAGTTTCTGAACTCTGTTTAATAGCAGGTCTCCTTTCTTGATAGTTNTTT GGTACTGCCAGTTTTTGTTGTCAGGTCTGTTGGTTTCCACTACTTCATTCACTTTATCTATTT TGCAGTGAAGCCTACCAGCACCAATAAACCTGGAGAGTTCCTGATCAATGAACTCCACAC CAACACCAAAAGCTTATGCCATATAGACCAGGAGTAATGAACTGCACGATTCCAGCTGGT GGCTGTACGCATGTATTGGCATTTCTCTACGTTATATCGATAATGAGAGCAAAAGTCATCC

TTTTTCTTTGCTTTCCCCATATCTACACT

>'990928a-089.scf came from CONTIG 57 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-089.scf(42>552) GCACGAGGGGGGAGAAAAGGGGTCAGGTTCTTCTCGTGTCAAGCAAATTCTGCCTCAATT

AACTTAACTATTGCAGCAGGGTACCCAGGCCTTTCGGGAGTCCCTGGACTGTCTGCCTAAC CACATGCAGTCAGCCGCTTAACGCTACACCAGTCTCATCCCCTCTGTCCCCCATTCACAGG CCGGGGGAGTGGGGGAGACAGTTGGCCACCTTCCTCTGTATATTAATTGGCATGATATGG TATTGTATAGGATTTTAGCAATTCATGATAAATATGTCAGGCTAGGCTTTACTATTTTAAT GCTTATGGACATTGTATATTTGTATTTTAAGACCAAGTAGACCAAGTCACAAAGGTCTCTC

TCTAGCGTACCATACACCCGNGGCCGGNAGAAGGCTGGAAGGCTCCACCAGTTCTGAAGG CAGCTGCTTTCCTGTCCTCTGTGCTGGACGGCCCTGTCCACTATAACTAAACTGGCTCCGA GGGTACGCATAGNGGCTTACGTCTCA >'990928a-091.scf came from CONTIG 58 at offset

0;"E:\SEQUENCE\export\EST_db\990928a\990928a-091.scf(43>555)

GGACGAGGCGCCTGCGGAGCGGCGTGCCCGGCGTGCGGGTGCTGCAGGGACTCGGTGGA CTTCTCGTTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCAACGAGAAGGT GGAGCTGCAGGAGCTCAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGA GCAGCANAACAAGATCCTGCTGGCTGAGCTTGAGCAGCTCAAGGGCCAGGGCAAGGCGC

GGCCTGGGGGACCTCTACGAGGAGGGAAGAGCGAGAGCTGGGCCGGCAGGGGACCAACT CACCACGACAAAGCCCGGTCGAGGGGGAGGCGACAACCTGCCGAAGACATATGAGGGTC GGGAGAAGTAGGAGGAGAGAGCTTAAAAAAAAGAAGCGAGACATCTGCATCTTTTAACA GATGTGACATGGCTTTTGGCCGTTTGCCTGGAGGAAGGGGATCTTGAAAAAATGACTTTTA TAATGATAATAGAATCAGAACTAGCCAATCATAACAA

>'990928a-095.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EST_db\990928a\990928a-095.scf(44>509) GCACGAGGGAACTAAGGAACATATTGGACTTAACAAATGTGCTCTTAGAACTTATGTGTA TGTAGGGGGCTTACTGTGCTCTTTCTAAATAAAAGAAATATTGGGGCTACATGAGTAGCA CTTACCCATTTCTCATTCTCCAGTCTCTTCGATATTGTCAGGGATAGACTAAACAGAAGAC TTGTTTGTTTTTATACTAGCCAAAAATGTTATAACCTCTAAATATTCCAAAAATTATACATT AAGAATAACAGAATCAGAACATAAAATTCTAAAATAACTCTCAAACTGTGTAGATTAACA

TCTTGATTTATATTAAATCTTCAACAGAATAGAGAAAGTAACTCTGATTTACAAGGTCCCA GTATTTTTCTCTTTATATGACAGTTGTACATACTCAAGTGAGGATATAAAACCAACGAACT GTGATTTAGGATAGACTGGGGGTATTTGTCAGCAGCTTGGG >'991015a-001.scf came from CONTIG 1 at offset

0;"E:\SEQUENCE\export\EST_db\991015a\991015a-001.scf(42>686)

TTTTTTTCGGCACGAGGATGAGCTGGGTAGACCTTATCATCCCAGATACCCTATAAGCTCC TCCTTGCTTTATGGATAGCATTGCTGAAGATCACCGGCTGGAGAGCCCCACTACTCCTCTG CTAGAGGACACAGATGGTTCTCAAGACAGCCCTATTTTTATGTATGCTCCTGAGTTCAGGT TCATGCCACCACCTACTTATTCTGAGGGTGATCCCTCCGTCCTGAACACAATGTGCAGTGA

GCATGTGGAAGAAAAGAAGCAGTTGTACCTACCTGTTTCTCTTCATCTCTCTTCCTGGACT CTTTAATTTTTTAGAGACTCAACAGTCTCCACAGGGGGGGACAGGCCCACCCCACCCTCTG TCTCTCCAGGGGGGAGGGGGACAACAAGCAACCCCTGGGCCCTAAGGGGCGCACCCCCCT CACCACCCAATGATGGGATACNAAATTTTTGTAATGGGTTAAAACACCTACAAAAAAACT AGCCCTCCCATTCTTGATTCTTTTAAAGAGGATTTCAGAATTTGATAAGGGAGAAAGGACC

GGAGCGGCCCCGCGAAGGGGGATATAAAAAAATGTTAAAAAAACTTACCCGCCCGGGGG AACATAAAACAAAAAGAAAAAAAGAAGGCAATGGAAAAG

>'991015a-003.scf came from CONTIG 2 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-003.scf(45>709)

GTTTGCCGCCAGGACACAGGTGTCGTGAAAACCACCGCTAAACCTAAACCAAAATGGGAA AGGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCAGGGAAGTCTACCA CGACTGGCCATCTGATCTACAAATGTGGCGGGGATCGACAAGAGAACAATTGAAAAGATC GAGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAA CTTAAAGCTGAACGTGAGCGTGGTATCACCATTGATATCTCCCTGTGGAAATTTGAGACCA

GCAAGTACTATGTTACCATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAAATGAT TACAGGCACATCCCAGCTGACTGTGCTGCCTGATCGTTGTGCTGGTGTGGTGAATTTGAGG CGGGATCTTCAAAACGGGCAGACCCGCGAGCTGCCCTTTTGCTTAACCTGGGGTGAAAAA ATAATTGTTGCGTACAAAAGGATTCATGACCCCCTATACCAGAGAAAAGAAAAATGTTAG AAGCAGACCTATTATAAAATGCTACACCCGCACAAACTTTGCCCATTTGCTGATGGGCAA

AGCTAACAAGCTATATCCGGTAGGGGGGAAGACGAGGAGCAGCCGGACCCCGTTACTCG GTGT

>'991015a-004.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-004.scf(51>626)

GCACGAGGGAGCTGCCGGGCCGCCCAGAACACCGCTGGTTCCCCTGGCAACCCAGGAGA GCCAAACCCTACTCGGGTGGTTGCAGCGAGAGCGGGCGCGATGGTGTCTAACCCAGTGCA TGGCCTGCCCTTTCTCCCAGGCACGTCCTTTAAGGACTTAACGAAAACAGCATTTCATAGA AGCCAGACTCTGGGCTACAGGAATGGCTACGCAGTTGTTCGACGTCCAACAGTTGGGATT GGTGGGGACAGGCTCAAGGTCAACCAGCTGTCCCAGGCTGATCTGGATGAGCTGGCCAGC

AAGATCCCAATCCTCACGTATGGACAGGCCAGGCAGGCCCCGCCTGCAGCGTTTGTTCCT GCACATGTGGCTTTCGACAAAAAGGGGCTTAAAATTGATGCCTATTTTCAGAAGATGTTTC TATGTCATTTGAGAAAATTACAGGATTCGCCAGTGACATTTATATTATTAAAAATGAAGCT GCCGCATAGACCTGGCGGGAAAAATTGGGTACCTCAGGAAGTTATAAACCCAGGGCTTCC AATGACGGGGGACATACCTGAAGACTAAACGAAA

>'991015a-010.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-010.scf(44>590)

TTTTTTTGTATTAAAAAGAAAAGCATAATTACCACAAATTACAAACGACTAAAGCAGGAC TAGAATAATGAATGAATCACTTCAGCCTGAAAAGCAGATACTCTCAATAATATTAATGTT

ATAATACAAGCTCATTCAAGTATTTTACATTTTTTTTTCCTTGTAAATGTGATATCC CATGGTAAAGATAATGTACTATGAGCATAAGGTGGAACCTTCTCCGCAAAGCCAGATGAC AAGTTTTCCTCTCCAGTCAGATGGGCGGATGTTCTGATCTTCTTGCCTCTACCATCATGTGG CTGAAGAGAGGGGGGGGCTGGGGCAAACCTGGGACCCTACACCACAAATACTGGGGGGC CCATCAGAAGGGGAACCAAACACCTATTAGGTTTTGGAAAAACAGCCCCCCCCTACTAGT GGTTTTTTGCCCTCCTCCCTGCAGGGCTTTGACAGTTTTTTTGAAATAACACAGAAAGGGA AGAGAATAAATAACAAACAAATACACTTGAATGGGGCCTCCTGGCTTGACCAGGGGCAGC GGG

>'991015a-012.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-012.scf(41>316)

TGCTGGGCCGGGAGCGGCAGCGGGTGCAGGGGGAGCTGCAGTCCCTGAGCCAGCGGCTA CAGCAGGAGTTTGTGCCCATGGCCGGAGGCGCAGGACCAGCTACAGCAGTTGGGGAGGA GTGTGGGGCTGCGTGACATGAGAACTTGTCCCTGGAAAATCTGGCCCACCGAGAAGGCTT

GTGGAAGCCGCCTGGGCTTTTTTGTTCAGATGTGTTCTGGGGGTTGGGGGTTTGGCTGGTC TCTGACCTGGGTGGGTCAGGGGAGTGTTGGGGACGGT

>'991015a-013.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-013.scf(49>665)

GCACGAGGGGCCCTATGGCCAGTGCAAGCTGCTGCGCACGCACAACTACCTGTACGCGGC CTGCGAGTGCAAGGCCGGATGGCGGGGCTGGGGCTGCACGGACAGTGCGGACGCGCTCA CCTACGGGTTCCAGCTGCTGTCCACACTACTGCTCTGCCTGAGCAACCTCATGTTTTTGCC ACCCGTGGTCCTGGCCATTCGGAGCCGATATGTGCTGGAAGCGGCAGTCTATACCTTCACC ATGTTCTTCTCCACGTTCTACCATGCCTGTGACCAGCCTGGCATTGTGGTTTTCTGCATCAT

GGACTATGATGTGCTGCAGTTCTGTGACTTCCTGGGCTCCTTATGTCCGGTGGGTGACTGT TATTGCCATGGCTCGCTTTACAGCCTGTGGCAAGCAAGTGCTATATTGCTGGGGCGATGCT GCTGGCATGGTTCTGAGCTTGACGGATGGACTCTGGACCTGTTGGACCGAGCTTTTTGTCT GGGATTTGGCACAGCCGGAAGAACCAAGGCGCCGCGGGCTGTTCCCCCCCAAGGGCGGTG GTTTTTGCTGGCCGGCAGCCTCGAAGAGGCATCTGCGTTGTTTGTGAGACGAAAACATTAA

TTAACATTGA

>'991015a-015.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-015.scf(44>735) TTCGGCACGAGGGAAGAATTTAGCTGCTGCGTATGACAACTTTGTTGAACTTGTGGCTAAT

TTGAAGGAGGGCACAAAGTTTTACAATGAGCTGACTGAAATACTTGTCAGGTTCCAGAAC AAATGCAGTGATATAGTGTTTGCACGGAAGACAGAAAGGGATGAACTCTTAAAGGACTTG CAACAAAGCATTGCCAGAGAACCTAGTGCTCCTTCAATCCCAACACCCACATACCAGTCC TCTCCAGCTGGGGGGCACGCACCAACGCCACCAACTCCAGCACCAAGAACCATGCCGCCT ACTAAGCCCCAGCCCCCAGCCCGACCTCCACCTCCTGTGCTGCCAGCAAATCGAACTCCTG

CTTCAGCTCCGGCTGCAGCTCTAGCTCCAGCCCCGGCTCCGGCAGGCTCTGGGACCACTGT ACCAGCTCCATCACAGACNCCCGGGTCAGCTCCCCTGCCTCAGGCCCAGGACCCCCGCAC CCACCTTCCAGGGATCCCGGGATTTGCAATGCCATGCCCTGGGCTACATCCCTAGCGGATG GCAGATATATGCGGATCCACAGGATACAAAACCTGGCAGCTCCTACCCGACCCCACACTC TACCCTCCTCACCCCCCACACCTATTCCCAAAAAAAGCAGTAAAAACAATGTATTAAAGA

AAAAACAACCGCAAAGACACCTTACTTG

>'991015a-022.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-022.scf(48>641) GCACGAGGATCGTCTTTAAACCCTGCGTGGCAATCCCTGACGCACCGCCGTGATGCCCAG

GGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCATCCAACTTCTGGATGA TTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAAGCAGATGCAGCAGAT CCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAACACGATGATGCGCAA GGCCATCCGAGGGCATCTGGAAAACAACCCGGCTCTGGAGAAACTGTTGCCTCACATCCG GGGGAATGGGGGCTTCGTGTTCACCAAGGAGGACCTCATGAGATCAGGACATGCTGCTGG

CCAACAAGGGGCAGCTGCGGCCCGGCTGTGGCCTAGGCCCGGGGAAGGCACTGTGCCAG ACAGACACTGGGCTGGGGCCGAGAGAACCTCTCTTCAGCTTTTAGCTAACACAAAAATTC AGGGCACAATGAATCTGATGAGGGCACTGATAAGAAGGAGAAAGAAGCGCAGCGAGCAG CTGTGACTGCGACATTCCCTCTCTTGGCTGGCTTCACAGGTTGAAGGAGAAAAAAA

>'991015a-025.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-025.scf(42>669) TTTTTTTTTTTTTTCAACAAACA^ TTCTAGAATCCCCCCCAAAAAAGAAAAACAAGATAGATGCAGAAAATGCAAATTCTGAG GGAGAGGAAAGGGGTCGTTGAGGAAGAAGGCTGAGGGGATTAAAAAGCCTAAGGTGATA GGGACTTGGCCTTAGGCCTCCTCTTCGGCCTCCTCACCGAAATCCTCTTCCTCTTCTGCGGT GGCATCCTGGTACTGCTGGTACTCGGAGACGAGGTCGTTCATGTTGCTCTCAGCCTCGGTG AACTCCATCTCGTCCATGCCCTCACCTGTGTACCCAGTGGAGGAAGGCCTTCCGGGGAAC ATGGCCGTGAACTGCTCCGAGATGCGCTTGAACAGCTCCTGGATGGTGTGCTGTTGCCATG

AAGGTGACTGCCATTTTATACCACGNGGGGGATGTCGCAACAGTTGTTTGACGTGTGGGG TCCATTCACGAAAAACTGTGTTTTATCTGACGTGAGCTTGCTCTTTACTCCTCTTGGACTCG CCCAGAACCACAGCCCGGGAGACCGCCTGCGGGGCAAGGCGCTCTGTCTTGGTCGAAATG TGGGAGCCAGACGGGGGCCGGA

>'991015a-028.scf came from CONTIG 10 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-028.scf(42>718)

CCGCTCCGGAGCTGCTGCCGCTCCTGCTCTCAGCGCTGCAGTGGAAGGCAGGGCCGCGCC GCGCCGCTCCTTTTTGAAATATATAAATTGGAGGCCGGGCCGGCCTCGGCGCGCCCCTCTG ACAGCGCGGGCCGCGCCCCCTCCCGCCGGCGCGCCCGCTGCCAGCCCCGGGACCTTTTCA

TCTCTTTCTTTTTGGGCGGAGGAGGCGAGTTTAGATTCGCCACTCCGGACCCGAAATTGAC ACACTGAACTCCGTTTTCTTCTGCTAAATTATTTCTGCTTAATAGCCACTCGTTTTTTπ TGTCCCCCCTCCCCTCCATCTCGTTGCTTCAAGAAAACTTTGGCGACTCCCTAAGTGCAGG TTTAGATAGATACTTTTTTTTTGGCCTTGATTTGATTGTTGCAA^

TACTGTTTGTTTTGAAGTGTGGGTTTTTT^

AAATGTTATGTGGTGGGCGTTTTTTGTTTGCCGGGGTTACTGTTCTTTCACCGTTGCCTTCT GCAAGTGGGTGGGGGCATTGATTTATTCCCCCCAAAATCCCCCCGGGTCCGGGTTCTCACA >'991015a-029.scf came from CONTIG 10 at offset

0; "E:\SEQUENCE\export\EST_db\991015a\991015a-029.scf (42>653)

CCGCTCCGGAGCTGCTGCCGCTCCTGCTCTCAGCGCTGCAGTGGAAGGCAGGGCCGCGCC GCGCCGCTCCTTTTTGAAATATATAAAATGGAGCCGGCCGGCCTCGGCCGCCCCTCTGACA GCGCGGCCCGCGCCCCTCCCGCCGGCGCGCCCGCTGCCAGCCCCGGGACCTTTTCATCTCT TTCCTTTTGGGCGGAGGAGCCGAGTTCAGATTCGCCACTCCGCACCCGAAACTGACACACT

GAACTTCGTTTCCTCCTGCTAAATTTATTTCTGCCTAATAGCCACTCGTCTTTTTTTTTCC CCCCCCTTCCCTCCCTTTCGCTGCTCCCAGAAAACTTTTGCCGACTTCCTCAGTGCAGGTTC CCCCTGCCCGTGGTGGATTTATATTTCACTTGGGAACGACGTGGGCTTTTTTTTTGAAGGG ATTCAAGCAAGATCTTTTTTTTTTGGCATTGGCTCTCGATGGTTGCAAAGTTGGCATTAAA

AAATTTTTTTCCCTTTAAAAAGCCTTTTGGGGTGGGGGGTTTTGGTCTGTTTGGTC

>'991015a-030.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-030.scf(46>759) GGCACGAGGGAGATGTTCGAGCCCGGCCGCATGCACCGCGTGGGGGCGCTCGCGGCCCAT

AACTACCTGCAGACCCCAGCGGCCGGCAGCTCCGCGAGGCCGCGCAGCGCTTCCGCCGCT GGCAGGCCCAGCGCCCAGACTGGTTCGAACTGGAGAACCTCCGCTCAGCGGACGGCCGGG ACCTCCCGTCCCTGGACGAGGAGGCCTTCGAGGAGGAGCCGCTGCCCGAAGAGGGATCGT CCGGCAGGAGCCGCTGGTGCGGGAGCCCACCTCCCGGGACCACCTGCTGGTGGGAGCTGC TCCTCGCTGGAGAAGGAGGGGGCGGGCTGGGGCGGGTGGAGCCCCAACCCCGGGCCCGG

GGCAGCCGGCAGCCCCAACGCTCCATACATGGTGGTCCGGGGGGAAGGTCCCTCGGGCTA GGAAGGGAGCCCGTCCACAGGAGTGGGAGCGGGCTGGCGGGTGGCCTAATGAGGGAAAG AGCCTGCCGCTTTGGGAGCCAGGACCCGGGGAAAAGTCCTTTCTTTCGAGGGGGGTCCGA CCCCACTGAACCAACTCAAAATGCACCCCCGGGGGACAAGGGGTGGGAGCGGAAGTTTTT TCAGACCCCCACCCCCCAAAAAAAAAAAAGAGGGGGGGGGGGAGGGGGGGGTCCCGGCG

GAAACGCACCCCTGGTTTTTATATAAAACCCCTGCCGGGCCTGGGCTCCCCCCCCCT

>'991015a-040.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-040.scf(47>728) GCACGAGGGTTAGAAAAAGAATACATGATTCTAGAGTTGCTGGTTTTAACCCTGCACTAC

AGTTAATCCTGACGAGGACAGACAAAACCTTAAACAAAAAACTTGGCCAAAGCAAATAA CTTCTTAAACAGTCAAGATCTTGGAGACTCTAGAGGATTTTTGTACTAGTAGCCCAAGGAA GATGGAAAAATGACTCCTTTTTAAATCTGATTCAGACTGTCACTGCTTTGGGAAACTGCTA AATTGTTGGATCTGCTTCCAGGGTCTATGCATCTCTTGTTCAGCATGAATTTAATTAGTAGT CCAAGCCAGACTGTTCCTCTGGAACCTGACTAATCCATATTTCCTATGTTTTGGAATTAGC TTGCTCCTCCTAAAAATCTCCACAGCCTAATATTGATGTTATTATGACAGGGAAGCCTGAG GAGAAGCCTATACTGTGTGGACTTTAATTATATTCTAGAATAACTTTTGGGGAAAGCTCNC TGTAGCTGATTCTAGATTATCCAGAAAACAATTAACTTTAATAAAACTATTTGTCTAATCC CCTCTATTATATCAGGATACTATTTAATATTAGATATTATTATTACAAACATCTATGGTTTT

TGTTATCTAGGGGTTGATTTTACGTCCGCAAAAACCATAAAGCAACCATCATAAAAAAGC AAAGCCTTATCTG>'991015a-044.scf came from CONTIG 13 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-044.scf(47>695) GCACGAGGGCCGAACGCAACGAGCTTCGCAGGAGGCGGTGGGAGCGACGGCGGGGGGCT GAGCTTTGGGGCGACCCCGCTTCCCTCCTCCCAATCGCTTCGCTTCCCTTCCCCGCGGGCA

GCATGAAAGCCTTCAGTCCAGGGAGGTGCGTTAGGAAAAACAGCCTTTCGGACCACGGCC TGGGCATCTCCCGGAGCGAAACCCCGGGGGACGACCCGATGAGGCTGCTGTGCAACATGA ACGACTGGTACTCCAAGCTCAAGGAGCGGGGGCCCAACATACCGCAAAAAAGAAGGAGA GCAAGAGGAAATGCTGGAGGACGAGATCGACTACATCTTGGACTTGAGATCGCGCTGGAC TCGCAACCCCCATTCGTTAGCCGGGCCACCAACGACCCGACAGACCGGCGTCCAGGACGC

GCTACCAACTCAACACGACATAGATCTGGCCTGCAGAAAACCCCTCCCCCGCGAGCCGGG AAGCGGAGCAGGCGAGGGCCTAGGCTCATTAAAAAGATAAATTTTATACTTCTGTTTGTTT TAAAAAAAAAATGTGGGAAGAAGGGGGGAATGTAATATAAAAAAAGCCCAACGATTAAT AAAGGGGGGGAATGGGAAAAAAATTTTTTTAAGTTTTCTTTGGGGAGGGG

>'991015a-046.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-046.scf(47>699)

GCCCGAGGGCCAGTTTCTCAGTGAACATGCAGGAAGTTCAAACGCCTTCTCTAGTGGAGA GCATACCAATTACTATTTTGATGTTTCTCATGAACACCTAGAAGGTGCGCTAGACAGATTT GCACAGTTTTTCCTGTGCCCCTTGGTTGATGAGAGCTGCAAAGACAGAGAGGTGAATGCA

GTTGATTCATAACATGAGATGAATGTGATGAACGATGCCTGGAGACTCTTTCAGCTGGAA AAAGCTACAGGGAATCCCAAACATCCCTTCAGTATATTTGGAACAGGTAACAAATATACT CTAGAGACTAGACCGAACCAAGAAGCATTGGATGTAGACAAGAGCTCCTGAATTCCATTC TATTTATATTCATCGAACTTATGGTATTTGTGTTTTTAGCCGAGATCTTTGATGATTTGCTA TCTGGTGGGAAGGTATTTGTGAAGAGAGACAAAATGCCCCGTGCCGATTTCCGACATCTTT

CCAAGAAATCTTAACACTTTCAAAATACCCATTAGTTTTAGATCTTTGGACATCCCTCCTG CTCCCAAACACAACAACCCGCCTTTCCGCTCCTTGGCAGAGGCCGAGCGTTTAACTTATAA

>'991015a-047.scf came from CONTIG 15 at offset

0;"E:\SEQUENCE\export\EST_db\991015a\991015a-047.scf(47>625)

GCACGAGGACATTCATGTCTACTTAGTTCCTTTTCTCCACCCAGTACCAATCACTTTAATTT TCCAAGTTGTATTAGCTTCCAGGCACCTGCATTTCAAGGTAGCATGCTTTGCTGGCTCCCT ACTCCCCGCTCCATCTGCAAGAATAGGTCTGGTACACTGTGAGTCCTTCTAAACTCCATGA TGAATCACAGATACTGCCATATTCATGACATTGTAAATGGCCACCCCTAGTCACCATGTCA

ATGACCTCTTTGTCAAGCTTTCCCTGGTCTTGCTGACCATTTCAGCTCTATTTTAGATACAG TGTCCCAGTCCTGTCCTCCAGCCAGGAACACCCCAAAGCCCACTGGTTAAATCTCTGCGTG CTCTCGAAACCTTACATTGTATTCAATTTTCCATTGCATCATTGTCTATACATATCAATATC ATGAAATCAATCCTGCTTATAAAGAACCATCTTTACATAACAGATATAAATTAACCTTCAG ATTATACTGACTAAACAGAAAAATCCTGTCAGCCTCTTATTCATTGATCTTACGGGATACC

TGTGTTTTCATTCTTATACTCAGCTTT

>'991015a-048.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-048.scf(47>653) GCACGAGGTTGCGGCCCACCTGGTGTACTGGGGCAAGGCCATCATCATCTACCCGCTGTG

TGAAAACAACGTCTACATGCTGTCTCCCAACGCCAGCGTGTGTCTGTATTCCCCGCTCGCC GAGCAGTTCTCACGCCAGTTTCCATCTCACGACCTGCCATCTGTCCTTGCCAAGTTCTCCTT GCCTGTCTCCTTGTCAGAATTCAGGAACCCCCTGGCCCCCCCTGTTCAGGAGACGCAGCTC ATCCAGATGGTGGTGTGGATGCTGCAGCGCCGGCTCCTGGTGCAGCTGCACACCTACGTCT GCCTGATGGCCTCGCCCAGCGAGGACGAGCCCCGCGCCCGCGAGGACGACGCGCCCCTCG

CCACCAGGGTGGGCGGCCGCAGCCTCAGCACACCCAAGCCCTCAGCTNTGGCTCCCCACC AGCAGCGATGACATGACCCTACCAGCCCCAGCATGGACAACTCAGCGCTGACTGCTCCCC AGCGGGACTCGGCGCTGACAGGAGATGACGGAGACCTGCTGCCCACCTGTCCGACACGAC NGCCCGCATCTCACGGCCTCGGCCANAACCCGAGACCCCGATGCTGCAGCTCTGCCTATTC C

>'991015a-049.scf came from CONTIG 17 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-049.scf(41>656)

GTAATCTTCACATTCATTTTAGCAGGTACTGAGTGATGCTGTATATATAAATAAGTGTATT GTTTGATTTTTAGACCACCACATGACATGCTTGACTATTATTTCAAATGTCTGTTAATGCAA AGTAGGCTACTCCATAATAGTGTTAAGAACAAAACTTACTAACAAAGTGATATAAAGACT TAAATTAACACATTATGTGGAGCCCTATCTTTACAAAAGTTTTCTACTGTAAAATGCTTTT ACTTTTATTTGCAGTTTTCATTTGATAGTATTCAACCATAATTAAAGTTGCATAAGATAATT

GCTTCACATTTCACATACCTATATTTATCTGAGTGCTGTCTAAAACTGTTGTGCTAGCCAA AGTAAGGCTATGAAATCATTTGCAGACTAACCCCGAGTTTGTGTTAAAGCACTGTTATTGC CATGNGAGAGGCATTGACTTTGTACCACATCATGTTCAACCATTTATACATTCAGGGCCTT TTTTAAAAAAGAAAAGAAAACAAAACAACAAATAGAAGAGCATTATTGACAAAACTTTTT TTTCTAACCTGCAAAAACTAATTTCTGCCTAACGCCCTTACCCGACACCACCTTGAAAATG

CATGAA

>'991015a-050.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-050.scf(39>753) TGCTTGTTGGGAGAAGCAGGTACTTATAGGGACGACGCAAGGTGCCGGATGTGAAGAAA

AGCGGGGGCGTGGAGACTCGGACCCGAGGTGTGAAACAGATTCATTCTTTGCCTTGAGGA TCTTATCTTCCTGTGTGCATTCTCTGACGATTCGTTACCTACCTGGAGTGTCTTTGACTGTG GGCATCCCCCGGTGTTTTTTAAGCCACTTAAGCTGCTCCCATGCTTGTTTGACGTCTGCTTT GTCGAGTGTCCATGATGTTGGGCCCTGAGGGAGGTGAAGGCTTTGTGGTCAAGCTCCGTG GCCTGCCCTGGTCCTGCTCTGTTGAGGATGTGCAGATTTCCTTTCGATTCACGATCCATGA

CGGGGGTGGGGGTGTTTCTTTATTTACACTAGAAAAGGAGGGAGAGGGGGAGGCTTTTGT GGTCTTGATTAGAAATGACTATATTGGCCCTTAAAAAACAGGAAGCTGGACATCGTTCTTG AATGTGAAGCCCAAAATCGAATGTTGGGGTTTAGCAAGGGCCAAAGGGTATCTGCCTGAG GTTTGGCGTTCGGGTTCCGTGGTGCCCCGGAATTATTTTTTTTTTGGGGGAATGGCCTGGTT CTTTCGGGCCCGGGCCATTCGGGAGCTTGTTTTGTCTTCGATTTTAAGGTTTGAAACAGGA

TATGGTCTTTGGGTTAGGTCGATATTTTTTGTCCCCTTTTTTTT^

>'991015a-051.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-051.scf(41>646) TTCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATTTGGTGCTTGGGCCGGTA

TAGTAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGGAACTCTGCT CGGAGACGACCAAATCTACAACGTAGTTGTAACCGCACACGCATTTGTAATAATCTTCTTC ATAGTAATACCAATCATAATTGGAGGATTCGGTAACTGACTTGTTCCCCTAATAATTGGTG CTCCCGATATAGCATTTCCCCGAATAAATAATATAAGCTTCTGACTCCTCCCTCCCTCATTC CTACTACTCCTCGCATCCTCTATAGTTGAAGCTGGGGCAGGAACAGGCTGAACCGTGTACC

CTCCCTTAGCAGGCAACCTAGCCCATGCAGGAGCTTCAGTAGATCTAACCATTTCTCTTTA CACTTAGCAGGAGTTCCTCATTTTTAGAGCCATCACCTCATTACACAATATCAACTAAGCC CCCGCATGCCACATACAAACCCTCGTTGTATGACGAATATTACGCCGCCTATATACCCGCT CCTGATACAGCCGTCCAAGCTATACAGACGACCAAAACACTTTCGACCGCAGAGAG

>'991015a-052.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-052.scf (47>749)

GCACGAGGCTCCCAAGGGACGGGCAGCCATGCTTGTATTTTTATGGTTAGAAAGGCACAA AATTATCAACTAAGACATTCCTTCTTTCTCTTTTTITCCTGAACATCATGGAGTTTTCCAGT TGTCTCTTTTGGACTGTAGTTTTTAGTGTTTTAAACAAACACTTTACAATGTAAACTATT^

TTTTTTACTTATTCTGGGGGATCTGTCTGAAAGACTATTCATGGAACAGGAAGAAGCGTAA GGACTATCCATATCATCTTTGCTACAAGTCATTATGACTGTAAGATTGTAAATACAGATTA TTTATTAACTCTGTTCTACCTGGAATCTAGTTTCATAGGAAAGTGTTTGAGAGCAGGTAAG TTGAGATCGATCAGCAAATCTTTCACAGGAATGGCACAAGGAAACCAGCATAGCAAGCTG CTCTTACCCTGTGCTAGACTGGATGATTTGGATTCTTTTTTCTTTTTT^

TGGTTGCCCTTGCAGTGTTTTAGTTGCAAGAAAGCAAAGCCTTATACTGCTATCCATCCTG TGCTATTTCAGGAGAAGAAACACTATTTATATTTTCTTTTCAAAAAAAAAGAAAGAGACT GTTACAAATTCCTTTTGTGGGACGAAAAAATTGATAAAAAAAATAGGGTACAATTAATCG GAACAAAAAAAAAAAAACGGGGGCCCCCCTCC >'991015a-060.scf came from CONTIG 21 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-060.scf (42>635)

CGAATGGTGTGTACACTTGCACTTTCATCCCAGCAGAGGGACCATAGCTTTCATGATGTTC TTTAAGACAGCTGCGCCCCACAGCTGCCAGGTCAGGGCAGAATGAGTACCCAGGAGGAA

GGGCCTGCGTGTGACCCTCAGGCACCCCACCCACCCCTCCTGGTCCAGCCCACCCCCACTG GCTTTAACAAGTGAAAGTGAAAGTCGCTCAGTCATGTCCAACTCTTTGCGACCCCACGGA CTGTCCAGTCCATGGAATTCTCCAGGCCAGAATGCCGGAGTGGGTAACCGTTCCCTTCTCC AGGGGATCTTCCCAACCCAGGGATTGAACCAGGTCTTCTGCATTGCAGGCATATTCTTTAC CAGCTGAGCCACCAGGGAAGCCCAGCTTTAAACAATTAGTTTCACCAAAACCTTTAGCTC

CAGGAGGCGGCTTCTGTTTTGGNGCTGTGCAGCGACCCTCCTGGCTCCTGACANGGACGG ACGTCCACGGGCTGATTGACAGGTCACTGCAGGCTTCAGAACCGTCACCAAAAGCCCAAG ACCTGAAAGAGTTGGGCTGATTGGGGCTCCCCAACGGGGATGGCCTACCGC >'991015a-061.scf came from CONTIG 22 at offset

0;"E:\SEQUENCE\export\EST_db\991015a\991015a-061.scf(48>697) GCACGAGGCTTTTTTTTTTTTTGGTAAGGπ^

TTGGTCAAAGATAAAAACTAAGTTTGAGAGATGAATGCAAAGGAAAAAAATATTTTCCAA AGTCCATGTGAAATTGTCTCCCATTTTTTGGCTT^ CTGTTTCCAGAGTCAGGGGCAAGTGGGTTGGGTGGGAGGGAGCCAGGTTGGGGTGGAAG

GAGTTTACAGGAAGCAGGCAGGGCCAACGTCGAAGCCGAATTCCTGGTCTGGGGCGCCAA CGTCCAAGGGGGCCACATCGATGATGGGCAAGCGGGAGGTCTTGGTGGTTTTGTATTTCG ATCACTGTCTTGCCCCAGCTCCGGGGTGACTCGTGCAGCCATCGTAGTGACGCTGTAGGTG AGCGGCTGTGCCCTCGCCCGATCTCGATCTCGTTGGAGCCCTGGAGAGCAGGCCTCTTGAG GTGCAGTTGCTGGTCTGTAGCCAGCTTTTTGCAGGTAGGGAGTTTGGGAGCTCGNGGAAC

AGCGCAGAAGCAGTGGAGCAATCGAGATCGACCCGGCGCTACCGACGATCGCGCAGCTC GCGACAACCGCTTTTTTGGTTTTTGTACCATTTTGCCCCCGCGGGG

>'991015a-069.scf came from CONTIG 23 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-069.scf (48>644)

GCACGAGGCTCTCGTGTAAGGACTGACTACCTGGACCGATCGCCTGACAGATCCCACCTG CCTGCCCACTGCCATGACTGAGCCCAGCCCCAGCCCGGTCCATTGCCCAGCATTCTCTGTC TCCTCGTCGGTCTGTTCCACCACCTTCAGGGTCTTGCTTTGTCCACTCGTGTGTGACCTTTA GTCTCTAGGCTTTACCAGAAGCAGTCTGGGTTCAGCCAGTCAGTGACTGGCGGGTTTGAAT CTGCACTTGTCCCCACCATCTGGGGACTCCCCTTTCCCCGTGTTGTCCAGGACTCCCCATGT

GTCAGTGCTCTGCCCTCACCCTGCCCAAGACTCACCCCCCTTCCCCTCTGCAGGCCGACGG CAGGAGGACAGTCGGGTGATGGTGTATTCTGCCCTGCGCATCCCACCCGAGGACTGAGGG AACCTTGNNNNGGGACCCTGNNGCTGGGGTGCCCTCCTGATCTCCTCGCCCTGTATTTTCT TCATCTNCAGNTCTGGACAGGCAGNGGGCCAGAAAAGGNACCTANTTACCATTGCGNGGA GATGAGTCATGGAGGTCAAGGGAGACGACTCTGATTTCCAGACCCCCTC

>'991015a-077.scf came from CONTIG 24 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-077.scf(42>659) TTAGGAGCCCCATCAATAGAAAAAAACATAAAGGAAAAGGCAAACTACGACTACGAAAG

GGCAGAATCAGGCAGGGGCTTCAAAGCCGAAGGGGGGGGTAAAAATAAAAAGAAATTTT AATGGGGGGAAGAAGCAGACAATTAAGAAGGGGGACCCAAGGGGGACGGGGGGGCCGG GGAAGCCGGGGGCTACAAAAAAAGGGGAGCCGAAAACCCCGGCGGAGATAGGAAAAGG GGCTTCATAGTATTTTGAGGCTGGGAGGAGTGGGAAGGAAACCCCTAAGGGATGGGGAA AAAAGGGGCTGGAATATAGCTTTCGGTCCCCTTCTATTAAACATGAGGGGCCCAGGAAAA

AAAACTCCGGAGCCAAAGGACAGAGGGGGGGGCAGGGGGACTTCAGGGGGGGAGGGGG GAAGCCCGGGGGGGGCAACCCCGCTAGTCGGGGGGGGGGGGGCTGGGGGGAAAAACCA AAAAACCGGAAAAAAAACCTGGGAAAAAAAAAATATTCAAAAGGGGCTTTGGGCACGGG GGGGGGCCTGGAGGGCTTCTGGT

>'991015a-086.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-086.scf(44>139)

TATTCGGCACGAGGGGAAAAAGTCATGTGATAAATACTCCTTTTGTTCTATAACCAAGCCC CAACCAAGGACAAATTATGATATATACTGCAGGGG >'991015a-087.scf came from CONTIG 26 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-087.scf(44>525)

CGCTCTCAAGGGGCGGGCGGGGCTCCACTTGGGTGCTCCTAGAGCGGTGCCCGAAAGTGT GCACAGTCTCGTCTGTGTGCGTGTGGATAATATCCTGTGTCATAGAAATCTGGCTTCATAA

AACCATAGAATAAGTTTCTGGTATGAANGGTCCCTTCTCTTGTAGCTCTTCACTTGACGCC ACAAGACCATACCCAAGTGGGAGTTCGCTGATCGAAAAAGCACCTTCTTGGTAGAACCCG GGAAGGAACACCACGCTCGCCTGAGGGCCCTGAAGGGTCTCCTCTATAAAGCGCTCACAG ACTTGGTGTGCACCCCTGAAATGAACCAAGAATTGTGCGACTTGAACGGGGAGGTGTGGA GGGCCGGTTTGACTTCAGATTTCTCTGCTGCCGTGTTCTTCTGGAGGGCGACCCTTTCCAA

ACCTCAGAACGACACACAAGGGGCGGCCTGCGAAGAACGCTGCGGAATGAAGCATCTCT

>'991015a-089.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-089.scf(50>609) GCACGAGGATACAACAGCTTCCAGATGCACTTGGACAGCCAACAGTTTTTGAATGACCTC

AGAAATGATATTGAGAAGAAAATAGGATTTGATGCTATTATGCGGGTTCGCACCAGCACA GGTTTCAGAGCCACTGACTTCTTTGGGGGCATTTATATGAACAACACCACCGACGTAGAG ATGGCAGCAATCGACTGTGACAAGGCCGTGACCGTGGAGTTCAAGCATGATGACAAGCTC AGTGAAGACACTGGAGCCTTGATTCAGTGTGCCGTGCTCTACACAACTGTCAGCGGTCAG AGACGACTTCGGATTCACAACCTGGGCTTGAACTGCAGCTTCCAAGTGCGGGATCTGTAT

AAGAGCTGCGAGACAGATGCCCTCATCACTTTTTTTGCAAGGCAGCI ΓAAAGGCGTTTTT ACCAACCTTGAAGTCATTGGGAAATTTTGGTTACCAGACTGNCACATGTTGGCTGTTACGG AGACTGGCTAGCCCTCGCACCGCCAGTGATTTGCGATTCATAAGTCTGCGNGTACTGACTG TTGTGAGACTGGTGTGT

>'991015a-095.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-095.scf(46>593)

TTCAGACAGCTGGTGCCGAAGTTTCAGGAACATCCTCCTCTCTCCAATCATGGCTTGTGGT CTGGTCGCCAGCAACCCTGAATCTCAAACCTGGGGAGTGCCTCAGAGTGCGGGGCGAGGT GGCCGCAGACGCCAAGAGCTTCTTGCTGAACCTGGGCAAAGACGACAACAACCTGTGCCT

CCACTTCAACCCTCGTTTCAACGCGCATGGGGACGTCAACACCATCGTGTGTAACAGCAA GGACGCTGGGGCCTGGGGGGCCGAGCAAAGGGAATCTGCCTTCCCCTTCCAGCTGGAAGT GTCGTGGAGGTATGCATCCTCTTAACCAGACGNACCTAACCATCAAGCTGCCTGAGGATA CGAATTCAGTTCCCCAACCGCCTCACCTGGAGCCATCACTACCTGCTGCANGTGNGGACTC AGATCNGAGGGGTGGCTTTGAGGACTATGGCCAGCAGCCCTGGCCCCATAAGGAGTGCCT

GGCTCCCCTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTGAGGGGCCCGGACCCATC CCTTAAG

>'991015a-096.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EST_db\991015a\991015a-096.scf(43>550)

TGGAATACACAGCTGGGGCGGTGATGGCGTGCACTAACGGTTGTTTGTCCTACCCTTTTGG GCCAAGGGAGGGACGCAGCCCCGTCAAGTATCCGCCCGCTTTCAGCCTTACTGCCTTTTAT GCCACGGAGCCCCCGAAGGGCCGAAAGCCGGAGGGCCGCGGCCCTGGGCCCCCCGGCAC CCTGTGCAGCAGGCTTGCCTGAGCCCGGGTTGGGCTGGCGGCTTCTTTCTCTGTGGGCTCC CGGTCCCGGTCGGGTTTTTCAGGCCGCACCTACCGGCGGAGGAGGGATGGGGGACTTTGG

GTGGCCCTTTTTCCAGTGACGAGGTAGCTGACGATGGCGTATGCCATATGTGGAAGGATG AACATCTTTCCGAATTTACATTAAAAGATTAAAAGGATTGGTGGGAGGGATTCAGCGCCC CCTCATGTCCCCAGGAAGTGCCCCATATACATGGGGGCACCCCAACGGGAATCTGGGGAT GGCTGGAACCGGGCCCCGGTGCTGGG

>'991108a-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-001.scf (58>663)

GCACGAGGGTTTAAAAGACCGAGTCCAGTATGGGGGGGGAAGTGAGAGGCAATGGAGAA AAGCCAGAGGTCAGGAAGACAGCTCACGAGGAGGGAGGAGAGGTCTGCCTGAGCTCTGC AGATTCCTGGAGCAGGGGGAATGGAGAGGCAGCCAGGGGACCCCTTATAAACAAAAGAT

GGCCAACACTGGTCAACACCACTGGAAGGGAAAGCCCCGGGGAACACTCATCTTCACTTT CAAAACATGGGTAGAAGACCATTGTGAAAGATATTAAGAAGAACCGCTCAATCAAGGAC ATTACTAATATTACCATGTAGATGAATAAAAACAAACTGAACAGATCTAATGGAGATCCT TGGCCTGGCTTTGAAGAGATGGTTTTAAATTCCGGGACACCATTCCTCCTGNACCCATACT CTCCAGTTAGGTTAGCTGAAAGGAAAAATGCCTCTCCTAGAAGGGAGGCATAACACAACC TGGCGGGCAGCAGAATTTCCCTGAAAAAAAATTACATTGCTGTGCTAAAAATCACTTCTTT GTTGTTCTCTCCAGCCCCCCCGCCACGCCGTTTAAGGGGAGAAAAATGAAAAACAAAAAT TAGCCTTT

>'991108a-002.scf came from CONTIG 2 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-002.scf (53>440)

ATTCCTTAGTCTTCTCATTTCTTGAΛTCATTTTCATTCTTCCTCAGCACTGCAGCATCCTTTG CAGCATTCATTAAGGGGTTTCCTTTAAATACAACAGAAAGAAAAAAAAATTCAAACAAAA ATTGAGTTCTTTCAAAATGAACTAAGTACAGCTCATTATAGC1TCCCTCCAGTTGTTTGGG

GGAAATTGACTCCAGGTATTTATAAAACAACACCCATGGAAGCAAAAAAAGCTGAAGCTT GAGAGAACCTGATAAGGGAGAAGTTACAAAAGTTATCAGAACAGCTTTTGGCCTTTTGCA CCTGGGAAATTAAAGAGCAATCCAGGGGGGTTGGGAGAGGGCTGGATGGGACAAGGGCC CCACCTGGGGGGCACTGGCCAGGGG

>'991108a-004.scf came from CONTIG 3 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-004.scf (57>453)

GCACGAGGGTGGAGTTCGTCTCCGCACGCGTGACCGCGCTGGGATGGATTCCTCCTCGTCT TCCTCCGCGGCGGGGTTTGGGCTCGGTAGACCCGCAGCTGCAGCATTTCATTGAGGTGGA GACTCAAAAACAACGCTTTCAGCAGCTGGTGCACCAAATGACGGAACTTTGTTGGGAAAA

GGGCATGGACAAGCCTGGGCCAAAAGTGGACAGGCGGGCTGAGAGCCTGGTTTGTGAAC TGCGGTGAACGCTTCATTGACACCAACCAAATCATTTTGAATCGACGGAACAAAACCACA AATCCAACCAAGCCTCTCAAAAAGCTTTCTGACTGACTCACATTATCTTTTTGTAAAGAAG GAGATCAAGAAATGAAAGCAGTGATGGGGAGTGTAG

>'991108a-005.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-005.scf (58>458)

CACGAGGCAGGCTCTAACCCCCTCACATTCCTGGCGAACCCTCCATACTGCCCCGGCATCT TTGCCCTGCCTGCCTGCCCTGCCCTGTCCACTTGGGGGTTTGCTCCAGTATCCTATGTTGGG CTCTTGGGATCTTTTCTTTTTTCCCTTTGTCCTTGGGCCGGGAAGGTCCCCTTGGGCATGTC

CCCTTCAACCAGGTTAAGCTCTTGGCCTTGATGGATGACTAGAAGGTGGTGTGGATAGAA

AACCCGTGGTCCGATGGGGGGCCGTGGTTACCCTGTGGGTATGCATATCCCCGGTCCAGT GGGTTAGTTTAGTAGATATTTCGAATGATGTGTTCTAGATGCAAACCGTACACAAGGAGG GGTGCTGGGCACGAAATACCCCCTGCCAAATCCCAC

>'991108a-007.scf came from CONTIG 5 at offset 0;"E:\SEQUENCE\exρort\EST_db\991108a\991108a-007.scf (1>610)

CACGGGGGGCCGTTAAATATGGTCCCCCGGCTGAGAATTCGCCGAGCAAAGCCACAGGTC TACCTTGCCCCCAGTCCTCACAGCCGCTCTACCCAAGGGCCCCAGTTTGGGGGCATCACAG CTGTCACCGCGAACCAGAGCCTGCTGAGCCCCCTCAAGCTGGAGGTGGATCCCAACATCC

AGGCCGGCCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAACAAATTTGCCTCCT TCATCGACAAGGTGCGGCACCTGGAGCAGCAGAACAAGGGTCTGGAGACCAAATGGAAC CTCCTGCAGCAACAGAAACTGCCCGGAGCACATAAACAACATGTTTGAGAGCTACATTAA CAACTCCGGCGGCAGCTGGAACTTTGGCCAGAAAAACTGAACTGGAAGTGAAGCTGGCAC ATGCAGGGCGGGGAGGACTTCAGACAAAATGAGATAAAACAAAACGCCAGAATGAGATG

ATTTGTATATCAAAAGATGGGTGAACTAATGACAGGAAAATGAGTCGCCTGAGGCGATGA GAATAAATCTCAGCACGGTGAAAGAATCGAAAGAATCAATTTTAACTCGGCCGTCTGACA ACCCACCGACT >'991108a-009.scf came from CONTIG 6 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-009.scf (54>586)

GCACGAGGCAGGACGTCACCTTGCACGACTTGGACGTGGCCAACGCACGGCCCCAGGGG GGACAAGACATCCTGTCTATGATGGGCCAGCTCATGAAGCCCAAGAAGACGGAGATCACA GATAAACTGCGGGGGGAGATCAACAAGGTGGTGAACAAGTACATCGACCAGGGCGTGGC CGAGCTGGTCCCGGGCGTGCTGTTCGTGGACGAGGTCCACATGCTGGACATCGAGTGCTT

CACCTACCTGCACCGCGCGCTCGAGTCCTCCATCGCGCCCATCGTCATCTTCGCGTCCAAC CGCAGCACTGCGTCATCAGGGCACGAGGACGTCACCTCTCCTCACGCATCCTCTCGACCTC TGACCGAGGATGATCATCCGGACCTGCTGTACACCCGCAGAGATAAACANATATAAAATT CGAGCCANACAAGGGATCACATCAGGAGAAGCGCTGACCACTGGGAGATGGAACAAACC ACTGAGTACCGGCACTGCTGCCCGCCACTGTGGCAGATACGGAAGAGGATGAGA

>'991108a-01 l.scf came from CONTIG 7 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-011.scf (55>597)

GCACGAGGGGAAGGGAGATTGCTTTCTCCTACTGCATCTGTTAATCCTTTATCCAGAAGTC CCCCTGAAACTTCTTCACAGATGACTCCTAATCCATTACTTTTAAGTCCTACCACAGAACT AATGGAAGAAATTTCTGAATCTGTTGGAAAGAATCAATTTACTTCTGAAAGTACACATTTG AACATTGGTCATAGGTCTATGGGTCATAGCATGAATATTGAATGTAAAGGGATTGATAAA GAGCTAAATGATTCTAAAACTACACATATAGATATTTCAAGAATAAACTCTTCTCTGGGAA

AAAGCCAAGTTTGACTTCTGAATCCAGTATTCATACAATTACCCCTTCAGTTGTTAACTTC ACTAGTTTATTTTATAACAAGCCCTTTCTGAANCTTGGTGCAGTATCTGCATCTGACAACA CTGCCAGTTGCTGANAGCCTAGCACTACTTGCAGTCCAACCCCTANAAAAAAAAAAAAAA CGGACGCAGCCACTCACCGGGCCCGCTGTCCTGCTCGCCAGACTTCTACACTATGNC

>'991108a-012.scf came from CONTIG 8 at offset 0;Ε:\SEQUENCE\export\EST_db\991108a\991108a-012.scf (55>244)

GCACGAGGCCCAAGTGCAGGAGAAGCAGCACCCAGTGCCCCCACCGACTCAAAACCAAA ACCAGGTGCGCCCCGCTGGGGGCCCCGGGGGCCTCTGACACTGAAAGAGGTGGAGGAGC TGGAGCAGCTGACGCAGAAGCTGATGCAGGACATGGAGCATCCTCAGAAGCAGAGTGTG

CCCATCAACGAGT

>'991108a-O58.scf came from CONTIG 8 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-058.scf (53>714) GCACGAGGCCCAAGTGCAGGAGAAGCAGCACCCAGTGCCCCCACCGACTCAAAACCAAA

ACCAGGTGCGCCCCGCTGGGCCCCGGGCCTCTGACACTGTAAGAGGTGGAGGAGCTGGAG CAGCTGACGCAGAAGCTGATGCAGGACATGGAGCATCCTCAGAAGCAGAGTGTGCCCATC AACGAGTCCTGTGGCCGGTGTCATCAGCCCCTGGCACGTTCGCAGCCCGCGGGTCGCGCT CTGGGGCAGCTCTTCCACATCACCTGCTTCACCTGCCGCCAGTGTGAGCAGCAGCTCCAAG GCCAGCAGTTCTACAGCCTGGAGGGGGGCTCCGTACTGTGAGGGCTGCTACACCGACACC

CTGGAGAGTGCAGCACCTGTGGGCAGCCGATCACTGACCGCATGCTGAGGGCCACAGGCA GNCCTACCACCCGCATGCTTCACCTGTGTGTCTGCGCCTGCCCCTGGAGGCACCTCTTATT GTGGACAAGCCACCGCCCACTGGCCCCGACTACACAGCATACCCCCCAAAGCTTGGGCGC GGACCATATGCGACCTGCCGCGGGAGACGCGCGGGGCTTGACAGACTCCATAAGGTAAG GGCAGACGGGGAGCCTTCATGAGGAGAACGCGTTCCTGGTGCCCGTTGGGGAGCCACCCG

AC

>'991108a-013.scf came from CONTIG 9 at offset 0; "E:\SEQUENCE\export\EST_db\991108a\991108a-013.scf (55>115) GCACGAGGCAACTGTCAGAGAAACATGATGGGGTGAAGGTGGGTGCTTTTTTATAAATCG

T

>'991108a-014.scf came from CONTIG 10 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-014.scf (53>744) GCACGAGGACCACCACACAGCCCCTCCTTTCTGATGGCTCTCAACTCTCCATCCCACAGAC

TCACACCTCTGAGACCTGCAAAAGAAGCTCGCGGGTTCAGTCCCCCAGGGGGGGACCAGG GTTGTGGGGGGGACCGTTGGATATGTTGGAAGCGGTACTCGTACCGGCTTCACATTTTGTT GTCAACAATTTACTGTATTTTTTITTTΓTTT^ ATCAGAAGGTCCAAAAAGTTCGACATAACTATTTCAGTTTGCATTATTTATTTATGATGCT TTTGTCATTGTTTTTTTATACATTTGGG

CAAAGAAGTCTGTTAAATCATGGCCGGGGTGGGGGAAAAAATAAAAAACAGTTTTATTTT TAAAAAGGGGGACCCCAGTTTTAATGATCAAAGTTATAAATCAGAAATCCTGTAACCACT TCCTAAAAAAAAGGACCACAAATAACCGATTTTTTTATTACTCCTTGCCCAAGGGGCTCTA TGCGACACCCTTTTTTAAAAGGCGCTCTTTTTTAACAACTCTGTTCGCTTGCCCCGGGACCA CAGGTTCTTCGGTCTACCAAAATATTAATTTTTTCCAAAACAACCCCCTGTTTTTGACCTTA

CCTATTCTTTTTGCTGCCA

>'991108a-015.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-015.scf (49>678) TGGCTCCGCCACGAGCTCTGGGACCCGGGTCTGTGGCCGGCCCCTCGCTGGCCCTGTCTCC CAGCGACGGGCAGCTACTGGGCCGGGGATTCTGAGCTTTGCCTGCTCTCTTTGCACGTGAC ATGATGTCCCCCCTCCACAGCTCCTGGAGGACCGGCCTGCTGCTGCTGCTGCTCTTCTCTG TGGCAGTCAGAGAATCTTGGCAGACAGAAGAGAAAACATGCGACCTGGTGGGAGAAAAG GGTAAAGAATCAGAGAAAGAGTTGGCTCTCCTGAAGAGGCTGACACCGCTATTTAACAAA

AGCTTTGAGAGCACCGTAGGCCAGAGCCCAGACATGTACAGCTATGTGTTCCGGGTGTGC CGAGAAGCTGGCAACCACTCCTCTGGGGCAGGCCTGGTGCAGATCAACAAAAGTACGGG AAGAGACGGTAGTTGGGAAATTCACGAAACTAAATCTCATGGAGGAATGGATCAGCTGAC TATAAAGGGGGATGAATAGACAACACGTGGCAGGAGCACGGGGGCAGGGGAGATCTCCG CACGACCACCTACGACAATTTACCGGTTGAGACGACCAAACCAAATGTTTACCTTTAAGA

AGCGCCGGGGGCCCAAACCCCCCTAGGGGT

>'991108a-016.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-016.scf (48>563) TTTTTATATTAGTTTTGTAATCCCTACATTGGAAAGCTTTCCAAATTCTACTTGCATΠ

TAAAACTGTTGCAGTTTTTACTATTTATTTTGTTTCCCATGGTTTAAGAAAATAACTGCACA GTTTCAAAGGCATGGAAAATTATATCAGCCTTTATGTACTCTGTTCCCAAAATGGCAGGGT CTAGAGAAGAGCAGAATTCCAGCTTTAGAAAACATTCTAAGATTTCACGCATGCAGTTNT GACATATCTGAAAATAAGACTTTTGTATATTTGTGGTGGAGGNGGNTGGGGAAACTTTTA CAAAATGNTNNATTTΓTGTCAGTCTGTGGGCATΉ

TATTATGTGCACATTATATATTATTACTTCTTGTTTGATTTGTGATTCCCTATACTTGATTTT

TTAGTAACTTTTTTATAAAGAACTGCTCTTTTTTTTTAATTGATTGCGCTCAGATGAGCCC

AGTCAAAAGCAACATCAATGACAT >'991108a-017.scf came from CONTIG 13 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-017.scf (54>489)

GCACGAGGCTTAAACAGAAGACGGGCCCAGGCATTGTTGAACTGTCTCGTGCCCTCTCCTT GGATCTTGGATCTTGGTTTCCTCGGTAGGAGTTTCTGTCCCAGAGGCATTCAGGTGCATTT TTTTTTTCTCCTCCCGTGAAGGAGGTTCCAAACC^^ ATTGTATCTCTCCTTTCCTTTGTTCTCTTTTATGTTTTTTTT^

TGTTTTTCTCCATCAGTGGGGACTGATTGTTCCCCTTGCCGGCCAAATTTTGTTCCTTCCCC TGTTTTGGCCAAATCCTAGGGGNGNAAAATCCTCGTATGCCAAAAATATATGCTGAGCAT AAGTCATTCCACGTGGGTTGTCCATCGCAGCCGAGAAGCTGCAGNGGGGGCAGGGAGNN GGCGC

>'991108a-022.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-022.scf (54>474)

GCACGAGGGCGTGGTCCACGCCGAGCGATAGAGACGCCTCGGCCGTGTCTTCAGGATGAC GGAGTGGGAAACAGCTGCACCTGCAGTAGCTGTAGACCCCCGACATTAAGCTTTTTGGAA AGTGGAGCACCGATGACGTGCAGATCAATGACATTTCTCTGCAGGATTACATTGCTGTCA

AGTATAAGTATGCCAAGTACCTACCCCACAGCGCGGGCCGCTATGCGGTCAATCGCTTTC GTAAGGCACAGTGCCCCATTGTGGAGGGCCTCACCAACTCCATGTTGTTGCTTGGCCGGA ACATTGTCTAGAAGCTTCATGACCGTGCGCATCGTCTAGCTCGCCTTTTTTATCTTCCATTT TCTTACTTGTCTGATCTCCCTTTGTTCCTGTTGATCGTCTTTCTTAACTGGTGCCCCGT

>'991108a-026.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-026.scf (48>461)

CGCCAGGACACAGGTGTCGTGAAAACCACCGTTAAACCTAAACCAAAATGGGAAAGGAG AAGACCCACATCAACATCGTTGTCATTGGGGCACGTAGATTCAGGGGAAAGTCTACCACG ACTGGCCATCTGATCTACAAATGTGGCGGGGATCGACAAGAGAACAATTGAAAAGGTCGA

GAAAGAGGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAACT TAAAGCTGAACGTGAGCGCGGGGATCACCATTGATATTTCCCTGTGGAAATTTTGAGACA ACAAAGACTATTTTTCCATCATTGATTGCCCCAGACACACAGACTTCTTCTAAAACATGAT TATCAGCACATCCCAGCTGACTGTTGCTGTCTGCTCGGTTGGTGTTGTGTTGTG

>'991108a-040.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-040.scf (54>397)

GCACGAGGCAGGACCTGAAGGATCACATGCGAGAAGGCTGGGGACGTCTGTTACGCAGA TGTGCAGAAAGATGGAATGGGGATGGTTGAGGTATCTCAAAAAAGAAGACATGGAATAT GCCCTGCGTAAACTGGATGAAACCAAATTCCGCTCTCATGGAGGTGAAACATCCTACATC . CGAGTTTATCCAGAGAGAAGCACCAGCTATGGCTATTTCACGTCTCGGTCTGGGGTGGAG GGGCCGGGACTTCTCCTCCAAAGCAAGGGGTTCCCACACCTCTTTTCTTCTTTTCTACCCTA CTGAACAGNGGGTGGGGATTTTTTTTTTTTTTT^

>'991108a-027.scf came from CONTIG 16 at offset 317;"E:\SEQUENCE\export\EST_db\991108a\991108a-027.scf(52>486)

ACCGTTCGTTTTTTTTCATCACCGGATAACACCCGGGGAGGACCGAGGTTAATAGCTTGGT GAGCATGCATCTTTAACCAGGATCAACGGTNGACGGAACGATCACCCACGGATACTCCGG

TGATAGATGGGGATGAGGACATTACCTTCTTAAAGAGGTACCATTGTTTCTGACCCACTGT TAACCTTGATTAATTGCGGACCTGTGTTACAGATGAGACACGATTTATTTCTGCCTTTGAA CACTACTTGAGCTGATCCTTTCTTGTTGTGGGGCGAGCAGGTAGTACAATGCTCTGGGAAA GTGAAGGGTCCTAGCATGCGTGTNGTGTCGTCTATTCTTCTCAATAATCTGAGTTTAGATA TAGCGGGGC

>'991108a-031.scf came from CONTIG 17 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-031.scf(48>385)

CTGGTGTGAAGATCAATCCCAAGAACTACACTGATAATGAATTGGAAAAGATCACAAGGA GGTTCACCATGGAGCTGGCCAAGAAGGGCTTTATTGGCCCTGGCGTCGATGTGCCCGCCC

CCGACATGAGCACCGGCGAGCGGGAGATGTCCTGGATCGCCGACACCTACGCCAGCACCA TAGGACACTATGATATTAATGCCCACGCCTGTGTTACTGGTAAGCCCATCAGTCAGGGTGG AATCCACGGACGGATCTCTGCTACCGGCCGGGGAGTGTTCCATGGGATTGAAAACTTCAT CAATGAGGCTTCTTACATGAGTATTTTATGAATGACA

>'991108a-032.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-032.scf (53>555)

ACCTCATTCTGACAAAAGATTAAATCTTGTCAGAATGAGGTGATAGATAAAATTAAATCA AATGCGCGTGATTTAAGACGCAATCTCACTTTGCAGGAACGAAAGCTCTGGCGATATCTTC GCAGCCGACGTTTTAGTGATTTCAAATTTCGCCGTCAACATCCAGTGGGGAGCTACATTCT

CGATTTTGCTTGCTGCTCGGCGCGTGTAGTCGTTGAGCTGGATGGTGGGCAGCATGATTTA ACAGTTGCCTATGATTCCAGGCGCACTAGCTGGCTTGAGTCGCAGGGCTGGACCGTGCTG CGTTTCTGGAATAACGAGATTGATTGTAATGAGGAGACGGNGCTGGAGATATTCTGCAGG AACTGACCGCCGGNCACCCTCTCCCTGAAGAGCGAGGGGCAGACCGAGCCGATAGCGNT GTGGGAAAACATGAGACGGGCTGGAGATATCGCAGGGCTGACCGCCACCACGCCAGAAA

GGTAGGGCGGTGAACGTTGTGT

>'991108a-033.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-033.scf (8>608) GGCGTTAAATATGGATCCCCCGGCTGAGAATTCGCCGAGCGAAGCAAAAGAACCCTGTCT

CCTAAGCTAAGCCAAGCAAAGCTTGAAGCCAAGAAGCAGGTTGAAAGGTGTCCACAGCC ACAAAAAAAAAGAAGATCCGGACGTCGCCCACCTTCCGGCGGCCCAAAACACTGCGGCTC AGGAGGCAGCCCAAATACCCTCGGAAGAGCGCGCCTAAGAGAAACAAACTTGACCACTA TGCCATCATCAAATTCCCCCTCACCACCGAGTCAGCCATGAAGAAAATAGAAGACAACAA CACACTGGTATTTATTGTGGACGNCAAGGCCAACAAGCACCAATTAACAGGCTGTGAAGA

AACTCTTGACATTGACGTGGTTATGTCATACTTGATCAGCCTGATGGAGAGAAAAGATAT GTTGACGGGCTCTTCTATGATGCTGGATGTTGNNCACAAATGCATATCTAACTGAGTCACT GCTATTNCAATTAAAGTTTACTTTAAAAAAAAAAAAAACTAAGGGGGCCGGACCCATTCG CCTTGGAGTGATACATTACTGNCGGTTTCAGCGGATGGGAAAACTGGTACCATTTCCCTGA C

>'991108a-034.scf came from CONTIG 20 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-034.scf (54>619)

GCACGAGGGTGCAGTCTCTGAGTGGAGGGAGGGCCGACCAGCGTATCTCCGTCTCCCTGG GGAAAGGTGCTGGTGAGGTGGACGACATGGCCTGGTGGAAAGCTTGGGTTGAACAAGAG

GGCGTCTCAGTGAAGGGCAGCCCCCACTTCAACCCACACCCTGACGCANAGACCCTCTAC AAAGCCATGAAGGGGATTGGGACCAACGAGCAGGCCATCATCGACGTGCTCACGAAGAG AAGCAACGCACAGCGGCAGCAGATCGCCAAGTCCTTCAAGCTCAGTTTGGCAGGATCTCA TCGAGACCTTGAAAGCGAGCTGAGTGGGCAGTTGAGAGGCTCATCATATCCTCATGTACC CCCATACAGAACGAAGCCANGAGCTATATGATGCCATGAGGNCATAGAACCAAGAGGGC ATCATCNAATTCTGGCTCTCGGACCAGAACCACTCAGAGATATGAAGCATACAGAGACTA TGGTCACCTGAAGAAACACAACAACACACGCTACTGAAGATCGNGGCCTCTGCGCACAAA GACTGAGTATGGGACAGATGCCCGCAAGC

>'991108a-035.scf came from CONTIG 21 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-035.scf (48>532)

TTTTTACATGAAGCTACTCATATCAAGAGCAATAATCAGTCTTACAGCCAGACAGACTGTC AGTCCTCAAACTTGACTGTACTGACCTGACCATCTCCCTTTTCTCTCCAGACAATTGATGAT TCCCCTATTTTTAATCGAGGAGTGTCTGCTTTTCAACTACCCCTCCATGTCATACAAAAACC

CAACCATTTATAAACAATAGTTTTATATCTAGGTTATTGCTTTTTTGATAGCACATCCATGT GTATTATTACTTTCTTTTATTTCTTAACTATCTGAATGGAGTATTTCGTGGAAAGCTACAGC TCTGTTCACTTTTTTGCTTCTACACTTTGCAGATGCATGGTATTANGCACTGCCTCTTTTTA CATCTCTGATCATAATGCAGAGATTTTTCTTGTACACAAAGCAGATTATGATTCCTTCCAC GAGGACACTTACTAGATGCTTGCTCGCCCGCGCCTATGTAGGATAGATCCATC

>'991108a-036.scf came from CONTIG 22 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-036.scf (48>649)

CGTCTGAAGATTTTCTATTGCTGTCAAGTGCCACCTCATTGGGCCATTCAGCGCCAACTTG CAGGTTTACTCTTTGAGTTGGGATGTACCAATTCAGCCCTTCAGATATTTGAGAAGCTAGA

AATGTGGGAAGATGTTGTCATTTGCTATGAAAGAGCTGNGCAGCATGGGAAGGCAGAAG AAATCCTGAGGCAAGAGCTGGAGAAAAAGGAAACGCCAAGTCTATACTGCTTGCTCGGA GATGTCCTTCGAGACCACTCTTACTATGACCAGGCCTGGGAGTTGTCTCGACCCGCAGTGC TCGAGCCCAGCGCTCCAAAGGCCTCCTCCACCTGCGAAAGCAGGAGTTCANAGAATGCGT GGAGTGCTTCGAACGCTCTCTGAAGATTAAATCCATGCAGCTCGGAGTGTGGTTTTCTCTG

GGCTGTGCCTATCTGGCCTGNAAGACTACGNAGNTCAGCGAGGCATTCAGCGGGNGTGAC TCTGGAACCGACATGCTGAGCTTGAAACATTTATCACTCTATATCGCTTAAACAAAGNAA AGCTTTAAACATACAGAGCCTCAGGCACTTGACATGCGATCGGAAACTACTTCCTACCTG >'991108a-037.scf came from CONTIG 23 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-037.scf (48>672)

GGAGGCTCCATCCAGACCAGTGTGAATGCGCTGTCGTCAGATGTTCTGGGCCGCTGCCAG GTCTTTGAAGAGACTCAGATTGGAGGCGAGAGGTACAATTTCTTCACTGGCTGCCCTAAG GCCAAGACATGCACTATCATCCTCCGTGGTGGTGCAGAGCAATTTATGGAGGAGACAGAG CGGTCCCTGCACGACGCCATCATGATTGTCAGGAGGGCCATCAAGAATGATTCAGTGGTG

GCTGGTGGTGGCGCCATCGAGATGGAGCTCTCTAAGTACCTTCGAGATTACTCAAGAACC ATTCCAGGAAAACAGCAGCTACTGATTGGGGCCTATGCCAGGCCCTTGGAAATTATCCCA CGCCAGCTCTGTGACAATGCTGGTTTTGATGCCACAAACATCCTCAACAGCTACGGGCTCG GCCGCCCAGGGGGCATGGGGTACGGGTGGACATCAACACTGAGGACATGCTGACAACTTG AGCCTTTGGTGGGACCACGAGTGCGGACAACCCCTGCTGCCCTCGAGCCGGGCCTCATGG

TTGTGATGAACATATACCCCCTANAGGATGCTCCCACCCTGNCGGGCCAGCGGCCCCTCC GAGTTCACCCCCACAGGCCGCGTT

>'991108a-039.scf came from CONTIG 24 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-039.scf (47>609)

CAGACCTGAATTCCTTACAATCTGAGAAGTAAATAGATAGCACTTTGAAGGGGNGCCCAA CAGAGTTGGAGGCGTCATCAAAACTTTGGGTTCCCCTTTGCCCCCTCTAAGGGTTGGGCAG GGTGACCCTGAAGTGGGCACAGCCTGGAAATGGGGCTGGGGGATTGGACACCCTCCTGGC CCTTGATTCCCACCTCTGTCCTGTGAAGGCATGGGGAAGGTAGGGGCCCGGTACAAACCA CCCCTGCCTCCCCACTCCCCCCTGACCCCCATCCTCAGGGAGCCAGTCTCAATGGTTGGCT

TCCCTGTGCCCTGCATTTTTTCATGAACCCCACAAGCCCCTGTTTCCCAACCAGCTCTCAAT CCCTCTCTGCTCCTCCCCCTTCCTCCTGCCCTTTCCCCTTATATTTTCTCACCCTGGTGGCAG CTTGGGGGGGGCCCTACCCCCACTCTATGACTGGAGGGGAAGACATGCTAGCGAGGGTCC CACTCTACTCAGCACGACGCCCCCTCTCTACTCTGGGGGGGGCTGGGGNCGGCAGGCTCC TGATAGATTGGGTGGG

>'991108a-041.scf came from CONTIG 25 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-041.scf (54>671) GCACGAGGGGCCGCTCTTCCTGGCTTTGGGGTTCTTTCTCCGCGTAACGTGTGGTCTCTGA TATTCAACCCTCCTCCCAGCATAGGCTGCATGAGGCGGNGGCGGGCTCCCACATTCCTGCT CGGCGGAGGGGTGAGTGACCGGCCCCGCCCCTTCCGGTCCTCGAAGCTTTGCCCATGACC CGTACCCCAAAACCCAGATGTTGGCCTCCGAGGAGAGAGTGAAAACTGAGTATTTTGCCT TAAATTTTCCAAGCTTCTCTTGGTTTCAGGAATATTTTCCTTCGGGATGCAGAAGAGGAGG

GCCTGAGTGTTTATGCAAGCTAAGTGTTCCGGGGTGCAGTTTTGCTGGGGTGTTTATACGA CCCCGAATCCACCCCCTGCCCTTAGCCGCTCTGCTGCTGTCGCTGTTTTGGATGCCGACAC TGCTGCCTGCAGCCTCTCGCCTTCTGTTGCTACCCCGAGCCCTGCTGTCCATGCTCAGAAG TCCCCCGGCCACCCTCGCCGCCTCGGCTCCGCTATGCCCGCTCGTCTCGCGCCTTGNCACT GCCCACCAGAGGCGCCAGAAACGCAGGGGGACTTAGTGAGGAGAAGGCTTAGAAGAGAT

GGGACGCCCCCT

>'991108a-042.scf came from CONTIG 26 at offset 0;Ε:\SEQUENCE\export\EST db\991108a\991108a-042.scf ' (48>434) CCGGTTCTCCCCCAACCCCGCTCCGCAAGGGAGCCGTGAGGGCCGCAGACCCTCACCTTT

AGTGTCTCGGGAGCCAGACCAGTCCCCCTCACCCCACTATATAACAAACTCAGGGTCAGG TACTTCCCGCTTTTCCTTTACAGCAACCCTAAATTCAGGGGATTATGTTAACAGTACAGGG GATGTAACCAATAACCTATGGCCTTACCAATAGACGCTCCCCTGAACCAATCCGTCCCGA GGTACCCCAGCGCGGGGGGATTTCCGCCCGGCAGCGCCCCCAGACTCCTGCACCAACAGC CCGTCCACCCCACGGGTCACTGAAACAAATGAACGCGCAAACTATGCACCCTTTCCAAGC

TTAGGATCGGTTCGCCTCCCCGCCTT

>'991108a-043.scf came from CONTIG 27 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-043.scf(51>526) AAACCAAACTCTATCCAAAGTCCCAGAAAAAGCTTCACACTCCATATGTTCCTTTTGTTCT

AATCTTGTCAGCCAGTACAAGTGACCAAGTTCCAGTTATTTATTTCCAAAATTCTTGGGAA AAAAGTGTAATTTGACCAAAAAAGGATATTTGTTTTTGCTATTACACCAAATACAGTTCAA ATGCTTATTGTTCTATTTTTTTACCAATTTCAATTTCAAAATGTCTGAATGGTGCT^ TATAAACTTCAACACTCTTCCAATAACACTGCGTTACATTCTTTGAATCCTAGCCCATTTTC AGAGCATGACGGNGCTTACCATTAATAATTACCTTTCTTCTGAAACAGGCAAGCAAGAAA

TAGAAAAGACTTGCGTGTCAACTAACTCACCCGGCAGAACTAAAGAATTCTTGAGGCCAA AAAGAAAATTGTACGAATGGCCAACTAAGTTCTAAAATTGTTTAAAAAA

>'991108a-045.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-045.scf (54>653)

GCACGAGGATACGGCGTTGTCTTGAATTCCCGTCGTAACTTAAAGGGAAGCTTTCACAAT GTCCGGAGCCCTTGATGTCCTGCAAATGAAGGAGGAGGATGTCCTCAAATTCCTTGCAGC AGGAACCCACTTATGTGGCACCAACCTTGACTTCCAAATGGAACAGTACATCTACAAAAG GAAAAGTGATGGCATCTACATCATAAATCTGAAGAGGACGTGGGAGAAGCTTCTGTTGGC CGCTCGGGCCATTGTCGCCATTGAAAACCCGGCTGATGTCAGTGTCATATCCTCCAGGAAT

ACTGGCCAGCGAGCTGTGCTGGAGTTTGCTGCTGCCACTGGAGCCACTCCTATCGCTGGCC GCTTCACTCNCGGAACCTTCACTACCANATCCAAGCCGCATCAAGGACCAAGCTTTGNGG TCACCCGATCCCAGGCTGACCACACCCCTCACGAAGCTTTACGGAAACTGCCACCATGCC CTGGCACACGACTCTCTTGGCTCGTGGCATGGCTCCGGCACACAGGACGCCTANGGGTGA GGGGGAGCTGCCGGAGCCTGGCGGGCACATCTCGAACACCGGGAGCTGCGACTTCTTT

>'991108a-046.scf came from CONTIG 29 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-046.scf (54>638)

GCACGAGGCGCAGACTGGTTGCGCGCCTCTTTTTCTTCGCTGCCTCCCAGTTCTAGATTAA CCGGCGCCATGGGTTTTGGAGACTTGAAAAGCCCCGCTGGCCTCCAGGTGCTCAACGACT

ACTTGGCGGACAAGAGTTACATAGAGGGGTATGTGCCATCACAAGCAGATGTAGCAGTGT TTGAAGCCGTCTCCGGCCCACCACCTGCCGACTTGTGTCATGCCCTCCGTTGGTATAATCA TATCAAATCCTATGAGAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCA AGTATGGCCCTGCTTATGGGGGAGACACCACAGAAAGTGGAGCTACAGATAGTAAAGAT GATGACGACATTGATCTTTTGGATCTGATGATGAAGAGAAAGNGAAGAANNCAAGAGAT

AAGAAAATACGCCTTGCCAGATGAGTAAAGAAAGCAAAAACCACACTTGTCGCAAGTCTC CTCTTATTTACAGAAACTGGATGAGAGACGAATGCAAACTAAGAGGGGCAGACATCAAGC AAGCTGGGCGGGCTCTTTACAATCGGTGGTGCATAAAAACAAACAG >'991108a-047.scf came from CONTIG 30 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-047.scf (48>612)

CAGTGACCCAACTGCGGCAGATGCTGGAGAATCAGAAGAACTCCTCTGTGCCCCCTGGCT GAGCATTTGCAGGGTAAAGAAGCATTTGAGAAAAAAGTTGGGAATCATTAAAAGCTAGCT TGAGAGAAAAGGAAAGAGAAAGCCAAAACAAAACTGAAGAAGTCTTCCAACTCCCATCT

GAGATTCAAAAAACTTAAACAAGCCGTTAAAAAATTAAAGACTCGGGAGGTGGGTGATTT GTCGAAATATAAAGCAACGAAAAGCGNATTGGAGACACAGATTTTCGACTTTATACGAAA ATTGGCCAATCTGATAGGAAGTATGAGGAAGTATGGAGGAGGGTTTTTCATGCCCAAAAA GAAGAACTGTCTGCTAAGATGAGAAGAATTGCTCCATTTCACATANAGCAAGAAACAAAG ATCAGCAGAACGATGTGACAATCCTTCACACCATCACGAGCTACAAAAAAATACAGATCT

GCCAACAATCAAACAAANAATAAATACTGACGCTCAGAGTGAGAGATAAACGGCTCATG CCTTCCACTCCCATGAAGGAGCCACAG

>'991108a-049.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-049.scf (54>370)

GCACGAGGGAAAGATCCTGCACATTGACTTTGGGGGACTGCTTTGAGGTTGCTATGACCC AGAGAGAAATTCCCAGAGAAAATTCCATTTAGNACTAACAANGAATGCTGACCAATGCTA TGGGAGGTCACGGGGCCTTGATGGCAACTACAGGATCACGTGCCACACCGCGATGGGAGG TGCTCCGGGAGCACAAGGACAGCGGCATGGGCGCGCTGGGAGCCTTCGTCTATGACCCCC TGCTGGACTGGAGGGTGGAGGGCACCAATACCAAAGGGAACAAGCGATCACGGACGAAG

ACAGAATCCTACTCTGCT

>'991108a-050.scf came from CONTIG 32 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-050.scf (48>566) GTCGTGGGCTCACACCCGGCTTCTCTTCAGCCTTAACCTGTGCGCCGCCATCGCCGTCATG

CTAGGCGCCGCTGTCCGCCGCTGCTCTGTAGCTGCAGCCGCAGTCGCCCGGGCCAGCCCTC GAGGCCTCCTGCACCCCACTCCGGCCCCCGGCCAAGCCGCCGCTGTCCAGTCACTTCGCTG CTACTCCCATGGGTCACATGAGACAGACGAAGAGTTTGATGCTCGTGGGTGACATACTTC AATAAGCCAGATATTGATGCTGGGGATTGCGGTAAGGGATGAACACACTGNNTGCTTGAN CTGGNTCCAGAGCCAAAAATCATGATGCTGCTTGCGGCATGCGAACGTTTAATGATTTGTA

GNGCAGTCGCATCTAAAAGTGGTAAGACAAAACAGAACTATAAGAATCTACCCTTGTATT CAGAACTATACAACTTGATGACTGGAATTCACTCAAGAACGGCCTGAAAGGTAACCCAGA TGACTCCAGACTATGAATGTATGATTAATAACGAA >'991108a-051.scf came from CONTIG 33 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-051.scf(48>407)

CTCTTTTGAGTGCACCGTGAGTGATGTGTGTCATGCCTCTGGGGTGGAGGGAAGGGACCG ACACAGACGTACACTCCCACACTCCACCTGGTGAAAAAGGATGCCTGGACGAAGGTGGGT TCGGACCTTGGTCCTTGTGTGTGTAATGCCTTTGTGTCTGATACCAATGTATGGGCGGTTTC CAGCTGATATGGGTCCTGCCTCCCCTACCTTCCAACCCCCACTACACGCTGTACCCCAGTA

TGACCCCCTCTTTCCTAATGCCCATGGAATGTGGGATNTCGGGCACCCACACTGTCCGCAC GCCTCTTCTATTCGCACTGTTGCCTCTCCTCAACCATTAATCCTAACGGCCACATG

>'991108a-052.scf came from CONTIG 34 at offset 0;'Ε:\SEQUENCE\export\EST_db\991108a\991108a-052.scf (54>747)

GCACGAGGGCTGACTATTCTCAACCAACCATAAAGATATTGGGTACCCTTTATCTACTATC TTGGCGCTTGGGCCCGGCATAGCAAGAAACAGGTTCTTTAGCCCTTTGTAATTTCGGCGCT TGAATTAGGCCCACCCCGGAACCTCTGCTGGGGAGACGACCCAAATCTACAACGGAGGTT GGAACCGCACACGCATTTGTAATAATCTTTCTTCATAGTAATACCAATCATAATTGGAGGA TTCGGTAACTGACTTGTTCCCCTTAATTAATTGTTGCTCCCGATATAGCATTTCCCCGAATA

AATATTATAAGCTTCTGACTCCTCCCCTCCCTCATTCCTACTACTTCCTCGCCTCCTCTTTA GTTGAAGGTGGGGCAGGAACAGGCTGAACCGTGTTCCCCTCCTTACAGGCAACCCTTCCC AGCGGGAGCTTCTGTAAAATTTACCCTTTTTTC^ GGACCTCACTTCTTTCATCATTTTAACATAAGCCCCCCGCAGTAACATACCAACCCCTTGT GGTTGTTCGTATATTCCGCGGTCTTTTCTTTTTGTTCTGTTTTCAGCGGTTCTAGπ

ACGAACCAATACCCCTTCGCCGGGGAGGGAACCCTTTTTCTCCCTTTCTTCCTGGCACCCG ACTTTTTATCTCCGGCCGGG >'991108a-081.scf came from CONTIG 34 at offset 10;"E:\SEQUENCE\export\EST_db\991108a\991108a-081.scf(47>736)

TGACTATTCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATTTGGTGCTTGGG CCGATATAGTAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGGAA CTCTGCTCGGAGACGACCAAATCTACAACGTAGTTGTAACCGCACACGCATTTGTAATAAT

CTTCTTCATAGTAATACCAATCATAATTGGAGGATTCGGTAACTGACTTGTTCCCCTAATA ATTGGTGCTCCCGATATAGCATTTCCCCGAATAAATAATATAAGCTTCTGACTCCTCCCTC CCTCATTCCTTACTACTCCTCGCATCCTCTATAGTTGAAGCTGGGGCAGGAACAGGCTGAA CCGTGTACCCTCCCTTATCAGCCAACCTAGCCATGCAGGAGCTTTAGAGATCTAACCATTT TTCTTTAACTTAGCAGTAGTTTCCTCATTTTTAGGAGCCATCAACTTATTTAAAAAATT^

AATTACAGCCCCCGCAAGCCACAATACCACACCCTTCGGTTGTTGAATCCGTATAATTACG GCGTCCTCTAΛTATTTCGCTTCTGTTTTACAGTCGCTTCACAGTCTTTAACGACCGAACTTA ATCAACCTTTTGCCCGGCGTGGGGGAACCTTTTTTT^ TCTTTTTATTTAACGGT

>'991108a-054.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-054.scf (47>642)

TCAGGACAGCTACTGTAACTCCATCCTGAGGCTCATGTACGCATCTTTTCCTGAGACTCAA AACAACAAAACAGGGACTTAGATTTGGAAACTGACTTGGTCTGATGAACCAGACCTGTCT GAGCCTGCATGCCAGGAGCTGATCAGCTCCTCTGTACTTGCAAATCTAAGTTTTGCTCTTT

CCTTATAAGATGTGTGATCCCTGCAGTCTCTAATCCCCAGATGGAGGCCCACTCAGGTTAT CATCATCTTCAGATGGGGCTTCCCAGGTGACGCTAGTGGTAAAGAACCAGCCTGCCAATG CAGGAGACGTAAGAGACATGAGTTCAATCCCTGGCTGGANAAGATCCCCTGGAGAAGGA AATGGNCACCCATTCCAGTATTCTTNCCTGGAAAATCCATGGACATANGAGCCTGGGGGC GCAGATGGGAGATGACGNAGTGACTAACATAGCAGNCAGAATGGCAGGCATATTACTAT

ACACAAANGCTCAATGGNGAACACTGTCTGAACTTCTCTGCTTGTTATACACAGAATCATA TATACCACACACCCATTTACGAGAAAAGTGATTTATCCAGACCCGACACCGCTC

>'991108a-057.scf came from CONTIG 36 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-057.scf (53>131)

GCACGAGGAGCCGCTTCATTCTGCCCATCGGTGCCACGGTCAACATGGACGGTGCCGCCC TCTTCCAGTGTGTGGCTGC

>'991108a-060.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-060.scf (194>353)

ATGGCTTTGTGGGGATTCCTACTTTTCCTGACTAGGGTATTGGATTCCATACCCCCTGGCA

GTGAAAAGCCTAGAGTCCTAACCACTGGACCACCAGGGAATTGCCTATTTTTTTTAGGGCT

GAAAACCTAAATAGATGATGAATATACTTAAGCAGGAG >'991108a-061.scf came from CONTIG 38 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-061.scf (47>637)

TGGAGACTGGTGTTCTCAAACCTGGCATGGTGGTCACCTTTGCTCCAGTCAATGTAACAAC TGAAGTGAAGTCTGTAAAATGCACCATGAAGCATTGATGAAGCCCTTCCTGGGACATGTG GGCTTTAATGTCAAAAACGTGTCTGTCAAAGATGTCCGTCGTGGCAATGTGGCGTGGTGA CAGCAAAAATGATCCACCCATGGAAGCTGCTGGCTTCACAGCTCAAGTGATTATTTTGAA

CCATCCANGCCAAATCAGTGCTGGATATGCACCTGTGCTGGATTGTCACACAGCTCACATT GCTGCCAGATTGCTGAACTGAAGGAGAGATTGATCGNCGGTTCTGGAAAAAACTGGAAGA TGACCCTAATNCTTGAAATCTGGGGACGCTGCATCGNTGTATGGGTCCTGGCAGCCATGG NGNGAGAGCTCTCTGATTATCCTCCCTGGCCGCTTGCTGGCGNGACAGAGAAGACAGCGC TGGGGGGATCCAGCANGGACAAAGCAGCTGAGCTGCAGGCACAGNCGCCCAAAGCCAAA

GATAAAGAAATATCCCATACTGCCCCCCCTATAGGGGAAGACGGCCAACT

>'991108a-063.scf came from CONTIG 39 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-063.scf(47>551) CTTGGTTGTGTCTGGAAATCACCCCCGTGCAGCTGTCCTTCATGTGCAGGAGTGTTGCCCC

AGTGCTGGTGCAGAGGTGACTGTTTCCTGGCAGGGTGTGCCCAGGGCTTCCACAGAGGAG CCTTTTTTCCTTCCCCAGAAATGTCTCAGTGAAGAAGGGGGCAGGACAGGTGGCCTTGGG GACAGAAAGCAGACTAGACTTGCTGTCATACTGGAAGCTGGCCCTGTCCTCAGCACATAA GCAGCATTGGGAGCAGTCAAGCCTGGCATCCCTGAATTGGGGTTCAGGGGGTGTGCCCAG GTGCCCTCATGTCCCCACCCCCTCAGACTGCTGCACCCCAGACTGGGATGCTAGCCAGGG ACACAGACCTACATGTGTGTGTGCCCTGGTGTGCATGTGTGCCTGTGGGGCTGTGGGGATG GTCAAGCTCTGCCTGCCCTCTGTCTGAGCCATCTTGTGGACTTGGATTTTGCGCTTAGGAG GTGGTCTGGTGATGGGGGGGAG

>'991108a-064.scf came from CONTIG 40 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-064.scf (47>445)

CGCTGGGGAAAGGGCCTTTAATCGCGAGAGTTCCGTTCTCTTGAGAGCGCCTCCGCCGGC GCCTAGATCGCGCGAGACCGCGGAAGGAACCGAAGCGTGTGGCGCGCGCGGCGGCCGCG ACGGGAACAAGATGGCGACGGCGACCATAGCGCTACAGGTCAATGGCCAGCAAGGAGGG

GGGTCCGAGCCGGCAGCAGGGGCGGCGGCGGCGGCAGTGGTGGCAGCGGGAGACAAATG GAAACCTCCACAGGGGACAGACTCCATCAAGATGGAGAACGGGCAGGGCACAGCCGCGA AGCTGGGACTGCCTCCCTTGACGCCCGAGCAGCAGGAGGCCCTCCATAAGGCCAAGAGTA CGCCATGGAGCAGACCTTAAGAGCGGCTGTGAAACATACCTCG

>'991108a-065.scf came from CONTIG 41 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-065.scf(47>511)

CGCCCGCACAAGTGAAGAAGCACTACCGCCGTGCCGTGCTGGTGGTCCACCCCGACAAGG CCCGGGGGCAGCCCTACGAGCAGTATGCCCGGATGATCTTCATGGAGCTCAACGATGCGT GGGCTGAGTTTGAGAGCCAGGGCTCCCGGCCACTCTTCTGACCTGCAGGCACGGCTGCGT

GTCTGGCTCTGGAGCCGGTGCTGTGAGCGGCCCTCGAGGGTGGCCAGGGCTCCGGCGGCG TGGGCAGGCGTGGCTGCACCCGGTCGTCGCGTCGTGCCCATGTGCTCAGCGGGTCGGAGC CGATGGCGCTCCCGGCAGGAGAAGAGAAAGCATTCCAAAGCCTCCCAGTCTCTCTTTTCT GTCTTGGCCCCAAGAAACGTGCACTCCGTGCTCCACGCGTGTACGCTTGATCGTTNTGTCC AGGGCGCGTCACGAGTGGGCGCGCTGGCTGCTACTGCAGAGCGT

>'991108a-066.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-066.scf (47>571) TCGAGTTTTTTTTTTTTTTTTTTTTπ ATTATTTCTTCTTGGACACACCCACAGTGCGACCACGGCGGGCCTGTGGTCTTGGTGTGCT

GGCCTCGGACACGGAGTCCCCAGAAGTGGCGCAGCCCCCTGTGGGCCCGAATCTTCTTCA GGCGCTCCAGGTCTTCACGGAGTTTGTTGTCTAGACCGTTGGCCAGGACCTGGCTGTATTT CCCGTCCTTCACGTCCTTCTGTCTGTTTAGAAACCAGCTGGGATCTTTGATGGGCGGGGAT TCTGCATAAGGGGGATCACACGNTCCACCTCTCCTCGGTGAGCTCCCCGCCCTCTTGGGAG GGCGATGTCTGCTTTCCTCACACCACAGAGCATATCTTCCCCCCACCCTAATGCAGAGAGG

GAAAGCAATTTCCGCCGCCATGATTGTTGTGAGACTCCAGAGTGCTGGACTCTAGGATTCT AAAAATGGGGGGCCTACGGGGGGGGGCGGACCAACC

>'991108a-067.scf came from CONTIG 43 at offset 0; "E:\SEQUENCE\export EST_db\991108a\991108a-067.scf (53>641)

GCACGAGGTGTTGCGCCACTTGCGCCCTGGGCAAGGGATGCCCTGTGGGGTGTACACCCC CCGCTGCGGCTCCGGCCTGCGCTGCTACCCGCCCGGGGCGTGGAGAAGCCCCTGCACACG CTGGTGCACGGACAAGGCGTGTGCATGGAGCTGGCAGAGATCGAGGCCATCCAGGAAAG CCTGCAGCCCTCTGACAAGGACGAGGGCGACCACCCCAACAACAGCTTCAGCCCCTGCAG CGCCCACGACCGCAAGTGCCTGCAGAAGCACTTGGCCAAAATTCGAGACCGGAGCACCAG

TGGGGGCAAGATGAAGGTCATCGGNGCGCCCCGAGAGGAAGCCCGGCCTGTGCCCCAGG GCTCCTGCCAGAGTGAGCTGCACCGGGCGCTGGAGCGGCTGGCCGCCTCACAGAGCCGCA CCCACGAAGAACCTTACATCATTCCCATCCCCACTGCGACCGCAACGCAACTTCCACCCCA GCAGGCCCACCGCCCTGGATGGCAGNGCGGCAGGCTGGGGGNGGGACGGAGACGGAGGG AAGCTTCGGGGGCTGGAGCGAAGGGGAGCGAACTGCACAGTGCTGACACTT

>'991108a-069.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-069.scf (47>434)

CTCCCATGCTCCCTCTTTTGGCAAACTGTAAGTACTGTCTCAGCAAACAGCGATAATTTCA CAATTTCCTCTCTAGAATTGCTGAGAGACTTGAGTCACCAAACGTGGTTCACTACTGTGGA

AATGCATTGTTCAGAACACAGAAAGAAATTTAAGATTTCTGCTTTTCTGTGACAGTATTTG TTTCCGCCTCAGTTCAGAGTGTGAACTGCAGGTTCCTGGCAAGACTGCTATTTAACATTGC ATGTGAGAACCTGGTAAATAGGCAGAAAATCTTGGAGCTTGAAAGGAACCTCAGAATGAT TCATATGGTCATTCATTAGATTGGGACCTTTAAGGGATCTCTTTCAGCCTCTCTCAGTGCA GAAATCAGGACAGGGGTGCTTGG

>'991108a-070.scf came from CONTIG 45 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-070.scf (53>606)

GCACGAGGGTTGGTCCTGTTTGTTTTCTTGGCTAAGATTAGGACAAAGAACATATGAAATC AACAGAAAATATACCTTGGTACCACCAACCCATTTTATGCCACATGCAAGTTTTGAATAAG AATGGTATAGAAAATAACTTGCTACATATGTATGTACCAATTAGGAAATACTGATGCCCTT GTGGGCACAGAACCACATGACAAAACTTTGAAAATCATAAAAATATAAGATAGTGTGGCT GAGATGGAAACAGGCCTTATTCTTGAATCCCAATTTTCATCTCTCCTTI CCTATTTGGATT

TCTTTGGTGCTGTAGGAAAAAAAAAAAAAGAGAGAAAAATATATATTCATAAAAGATATG GNGCTCATTCCCATCCATCAAGGATGTGCTAAAACAATGTGTTTAATAAATTGTAATTTTA TGTACAGGTCTATACTGTTATCTATGTGTCCATTTTCAAAACTGCACGTGTCTCTGAATTCA TCTGACTCTATTTTTGACATTGCAGAAAATGATGGCATAAAATATGTATATGAAAAAATAA ACGTT

>'991108a-072.scf came from CONTIG 46 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-072.scf (53>612)

GCACGAGGCTGGAGCATAAGAACAGTGCTTATTTTCTTCTTTTCCAAGAGAACAGAAAGA AATAATGAAGCATTGGATGATTTAAAATCCCAGAAGAAAAAAATACTTGAAGAAGTCATG

GAAAAAGAAACTTATAAAACAGCTAAATTAATTCTTGAAAGGTTTGATCCAGATTCAAAG AAAGCA7y .GGAGTTTGAGCCACCGTCTGCTGGAGCAACTGTAACTCCCAGACCTGGACAA GAATTCGTCAGCGAACTGCCGCTCAAGAAACCTTTCTCCACACCAGCAGGCTCCAGCCAG GCCCTCCTCTGCAATTCCAGTTTCTCCTGGACACCAAGGACACTTCAGCCCCTGGTGGACC CCCAGAAGACTGNTACTCAGCCTATATCAATGTGGTACAAGACGTNTGGACCCCTGCTCTC

AGNGCTGGATGGGNCTCTCCTCTGGGCACCTTACAGACCATCTGCTCGAGACAGNGCTCT GATAATGTGATATTATGNGAGGCCCAAAAGNACCCCCTATGOS[ACAGTTtTTACATGCTGT TTGAAGAAATGAACATG >'991108a-074.scf came from CONTIG 47 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-074.scf (47>565)

CAAATTGAGATTTGCCAATGGAAGCATAAGAACATCGGAACTGCGACTCAACATGCAGAA GTCGATGCAGAGCCATGCCGCGGTGTTCCGTGTGGGGAGTGTGCTGCAGGAAGGCTGTGA GAAGATCAGCAGCCTCTACGGAGACCTGCGGCATCTGAAGACGTTCGACAGGGGAATGGT CTGGAACACTGACCTGGTGGAGACCCTGGAGCTGCAGAACCTGATGCTTTGTGCTCTGCA

GACCATTCTACGAGCGGGAGCCCGGAAGGGAGTCGCGCGGCGCCCACGCCAGGAGGACT TTCAGAGAGGTTGACGAGTACGATTACTCCAGCCCATCCAGGGNCAGCAGAAGAACCCTT TGAGCACACTGGAGGAGCACACCTCTCTACGTTGACATCAAGATGGAAAGNCACCTGGAG TACAGACTGTATCGAAGAACTTGACGAGATGACTGCGCACTNTCCCCACCTNCGCTCTATG AGAGATGAGCTTCCTGTCTGTATTGATATACTCAAGCGG

>'991108a-079.scf came from CONTIG 48 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-079.scf (53>531)

GCACGAGGCCAGATACCGCCCCCGGGCCCCCATCATTGCTGTGACTCGGAATCACCAGAC AGCTCGCCAGGCCCACCTATACCGCGGCATCTTCCCTGTGGTGTGTAAGGACCCAGTGCA

GGAGGCCTGGGCTGAGGACGTGGATCTCCGGGTGAACTTGGCCATGAATGTTGGAAAGGC CCGAGGCTTCTTCAAGAAGGGAGACGTGGTCATTGTGCTGACCGGGGGGCGCCCTGGCTC CGGCTTCACCAACACCATGCGTGTAGTTCCTGTGCCATGATGGACTCCGAAGCCCCTCCTC CAGCCCCTGTCCCACCCCTCTTCCCCAACCATCCGTTAGGCCAGCATTGCTTGTAGTGCTC ACTTGGGGCTGTAATGGGGCCTGTGGGGCGGGACACCAGGAAAAAAGAGAAAACCTTCT

GGAAACCGGCGGTTTTAAACTTTGCTGGGCCGGGTAGCTACACCTGGGCCCTCTCACG

>'991108a-080.scf came from CONTIG 49 at offset 0;"E:\SEQUENCE\export\EST db\991108a\991108a-080.scf (53>448) GCACGAGGGGAAGCGAGGCCGGAGCTGCGGGCGCTTTTTCTGCCCGCGGTGTCTCAGATT

CATTCTTAAGGAACTGAGAACTTAATCTTCCAAAATGTGCAAAAAGACCATCTTATGCCCC ACCTCCCACCCCAGCTCCTGCAACACAAATGCCCAGCACACCAAGGTTTGTGGGATACAA TCCATACAGTCATCTCGCCTACAACAACTACAGGCTGGGAGGGAACCCGGGCACCAACAG CCNGGTCACGGCGTCCTCTGTTATCACGATTTCAAAAACCCCCAAGCCACCAGATAAGCC GCTGATGCCCTACATGAGTACAGCAGAAAGGNCTGGACCAAATAAAGGCTTCCACCCTGA CTANAGTGTGGGAAATGGGGAGATATTGGGGGNAT

>'991108a-082.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-082.scf(53>377)

GCACGAGGGTTTGCACTCAGGTCCACGTGGCTCTGAGAAGGGTTCAGGCATCCGAGCTGT GGGGAGCCCTGGGTGAAGCTGGTTGTCCAGCGGTTCAGCCTCCTTGGAGGAAGCCCTCTG CCCGCCCACTCCAGAGCGTGAGAGTGTGGGGGCGTGCCCAGGGAAGGTGCCTGGGAGGA CGCAGTGACCACGCTCCCCTGGCACCACGCAGAAGTGGACGAGAAGCCCAGCCCACACCC CANGCCTCCTGGCTGTGCCCTGCGGCTGCTGCATTΓGCTTTTAATTCTCAACACTGGAAAA

TACTGACTTTGGGTTGGGCGGGGCC

>'991108a-083.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-083.scf(21>581) TTCTAGGTGGATCCCCCGGTGGTGGGGGTTGTGATGTGACATCTGTTTTTTATACCCTGTC

GTGGGCATTCGCGGTGGACGCCACACGCCCGCTGATGGCCGACATGAGGATAGACCAGGG CCGTAACCCTGCCTAAGTCCACACCTCTACCTTGCGTTTTATGTAGTTCTTTGCATTCTTTG TGGTGGTTGATGTTATTCCATTTATTGTGCTTTCATTTGGTTGGGGATGCCTGATCATTCCG GGGGGGGCTTTCCATACGCAGGATTGGCCTGCTTGAATTCCCGTCATTGGTTGCCCCTTCC CGCCGGGCGTAATGGCCTGGCGGGGGGGCGTGTATGTGGCCAAATGATACACCGACCGAA

TGGCCGCCACGGGCTCATGTCCGCAGGAGGCCTTGTGGTGATATATCTAACCCCCCGGGCT CTCTGGGATGAAAACCTATTTTGCCCTTCAACACTCCCGGGGGGCTAAATGTTTGGGCCTT TCGGTGTTCTCACCCACAGGGATGGCTACCCTTCACTGGTCAATATTCATTGTGTACACTG CCTCGTTTGCGC

>'991108a-084.scf came from CONTIG 52 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-084.scf (53>540)

GCACGAGGGTTTGGCCCAGACCCAACCATGATCCGAGCCAACTGCCTGGTCCAGACCACA GAGTGGAGTGCCTGTTCCAAGACCTGCGGAATGGGCATCTCCACCCGGGTTACCAATGAN CACGCATTCTGCAGGCTGGAGAAGCAGAGCCGCCTCTGCATGGTCAGGCCTTGCGAAGCT

GACCTGGAGGAGAACATTAAGAAAGCAAAAAGTGCATCCGGACCCCCAAAATCTCCAAG CCTATTCAGTTTGAGCTTTCTGGCTGCACCAGCATGAAGACATACCGAGCTAAATTCTCGG GAGGTGGCACAGACGGCGGGGCTGCACCCCCCACAGAACCACCACCTTNCCGTGGAGTCA AGTGTCCTGTGNNGAGGTCATGAAGAAGAGATGATGTTCATCAGACCTGTGCCTGCCTTA CACTGCCCCGGGACATGACATCTCGGTCCTGTTCTACAGAGATGTATGAGACATGGCTAA

GCCGAACA

>'991108a-085.scf came from CONTIG 53 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-085.scf (47>641) CCGCCCCCTGCTCCGGCAGCCCCCACTCTGGACTCTCCCTCCTGGCTTCAGCCTTACCGGA

GCCAGGGNGATCCTGCCCGGAAAAGGGAGCTCTGATGTCCCCTAGGAGAGGGAAGCTGG AGCCCACCCCCAGACAGCTCCTCCTCCCTTTCTGGCTGGCCCACCTGGCCGGCCCTGAGGC CTCACTGTAACCACAAGACCTTGTCTCTTCGCCTTATTCTTCTCACTGCCTCCTTGGGTCCC TGGCTCCTGCGAGGCTCTGTGGAGCTGGCTCCAGCAGCCACTTCCCTGCTTCCTCCTGCCT CTCTCCTGGCAACTGGAGATGCCAGAATCACTGCCGCCTGGGCTGGTAGCCGGGGCTGGC

CCTCCCCCTTCTGCCTGCTGGGGAAAGAAAGGCTAAGCTGGGTGGACTGGCCCTGCTGAG CTCCTCCCTGTCTGGGTGCAGGGAGCACCCAGATGACAGCACCCTGTTCTGTCATCTCCCT TCTACGCCTTCACCTTGGCACTTCCCAGTGAACGACAGCAGCTGGAGTCCACACGGCCTTT TTTCCGCCATCTTGGTCCGCCTTCCCNATGTACTGCCCCCCAGCGCCCT

>'991108a-086.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-086.scf (48>535)

GTGAGAAAGGAGCCCCTGGTGCTGACGGACCTGCTGGAGCTCCTGGCACTCCTGGACCTC AAGGTATTGCTGGACAGCGTGGTGTGGTCGGCCTGCCTGGTCAGAGAGGAGAAAGAGGCT TCCCTGGTCTTCCTGGCCCCTCTGGTGAACCCGGCAAACAAGGTCCTTCTGGAGCAAGTGG

TGAACGTGGCCCCCCTGGTCCCATGGGCCCCCCTGGATTGGCTGGACCCCCTGGCGAGTCT GGACGTGAGGGAGCTCCTGGTGCTGAAGGATCCCCTGGACGAGATGGTTCTCCTGGCGCC AAGGGTGACCGTGGTGAGACCGGCCCTGCTGGACCTCCTGGTGCTCCTGGCGCTCCCGGT GCCCCCGCCCTGTCGGACCTGCCGGCAGACGGNGATCGTGGTGAGACCGGTCTGCTGGTC TGCTGTCCCATGGCCGCGTGTGCCCGGGGCCCGCTGACCCCAGCCCCGGGGGACAGGGAG ACAGCA

>'991108a-087.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-087.scf (48>579)

CGAGTACACACGGGCTCCACATCCTCAGAGTCAGCCAGCCGCGGGTCCGGAGGGCCAGTT GTACTGCCTTTTTATATAAGGAACTTGGGCATTCGCGGATGTAGGCGGNGGGATGGAGTC CTGCAACCAGTCCCCCACGGATACCGGNGGTGACTGTGTATTATATTTGACCTAAATCTTT AGTGGGTAACATTTTATGCAGTTTGAATGAATAAAAATATTTTCCTGTTGTTTAGTTπ TGTATGTATTTTACTTTGATGAATGATTGGTTCCGAGGCCTCTGCCACACTCCAGAAATAC

TTGTGTGGGCTGTTTAAAAAAAAAAAAGCTGTGTGTCTGTTCACTTATTTCTCTAAATTAT CTCATTGCCTGGCATCAATCTTTCTCATATAGTTGTCCTAACCATTATGTACACANAAATG AAACAGATGGGAAGGAGACCAGAAAAAAAANTGATAATAAGAAAATGATGTTTGGCTCC ATGTTTACATTTTTTTATAAAAAGTGCAGAAGGAAAAAAACTGATAC

>'991108a-089.scf came from CONTIG 56 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-089.scf (55>589)

GCACGAGGCCCTGGCTCTGCTGGTTCTCCCGGCAAAGATGGATCTCAATGGTCTCCCAGGC CCCATCGGTCCCCCTGGGCCTCGAGGGTCGCACTGGTGGATGCTGGTCCTGCTGGTCCTCC CGGCCCTCCTGGACCCCCTGGTCCCCCNAGTCCTCCCAGCGGCGGCTACGACTTGAGCTTC

CTGCCCCACCACCTCAAAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATGATGC CAATGGGTCCCGTGACCGTGACCTCGGAGTGGACACCACCCTCAAGAGCTGAGCCAGCAG ATACGAGACATCCGNAGCCCTGAAGCAGCCGCAAGAACCCGCCCGCACTGCCGTGACTCA GAAGGCCACTCTGATGGAAGAGCGAGAATATGGATTGACCCACCAAGGTGCACCGGATG CATAAGTCTCTGCACATGGAACGNGGACTGGTTACCCACTCACCACGGGCCAAAAATGGA

TATACAGACCCAAGAAAAGACGCGGACGGGAAGAGACGCGATCCATGAGTGGG

>'991108a-092.scf came from CONTIG 57 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-092.scf (56>279) CACGAGGCAGGGCTCTATACCCCTCACATTGCCTGCTTACCTTCATACTTGCCCGTAAGCT

TGTCCTGCTGCCTGCCTGTCCTGCACACTGAGGAGTTCTGCAGACACACATGAGGGTCCTG AGATACTTCATTTCTCCCTTTGCGCTGACACGATAGGGCGCTTGATCTGATCCATCTACTG GTATTACCTTGTGCTGATGATGAGAGATGCGTCGGGAAGAA >'991108a-094.scf came from CONTIG 58 at offset

0;"E:\SEQUENCE\export\EST_db\991108a\991108a-094.scf (50>650)

CGCGAGCCCCAGGACCTGTGTGCAGTAGCCGCGCATCCCGAGCCGGACCACGTCGGAGTT CCTCTGGACCCAGACATCAAAGCCATGTCGAAGCACCACAGCGACGCCGGGACGGCCTTC ATTCAGACTCAGCAGCTGCACGCAGCCATGGCCGACACATTCCTGGAGCACATGTGCCGC CTGGACATCGACTCACCGCCCATTACGGCCCGAAACACCGGCATCATCTGTACCATCGGC

CCAGCTTCACGAGCAGTGAAGACATTGAAGGAGATGATTAAGTCTGGATGAATGTGGCTT CGTTTGAACTCTCTCATGGAACCACGAGTACACGCANAACCATCAGATGTACGTGAAGCA CGAGAGCTTGTTTCAATCATTCTCTATCGCCGGGCAGTGCCCTGGCACTAAAGACTGAGAT CGACTGGCTATCAGGGAGCGCACGTGAGTGGACTGAAAGGAGCCACTAAATACCTGGCAT GCTACTGTAAAGGAAAAAAATCTGGGTGACTACAAAATTGCGGGGGAGGGGGGAGATAG

GAGATGCTTTTTTGTGGAACAAGGCGACTCGGGGAGAGGGAGGGCCCTGCAAAAAGGGA AC

>'991108a-096.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EST_db\991108a\991108a-096.scf (55>568)

GCACGAGGCTCACGGCCTCTTGCTCACCCATGATATGGTCCCGTTTTCCTCTTGCCGCGTG CACCTCCACCCATTGTCTTGGTGGCACATGGGTGGAACACTTGATCTGCTCGAGTCTGCCT TCAACACACATTGCATCTTCAGATTTTCTACTTTTTTGTTCAAAACTAATATTCACCAAGTC AGACTTTGTGTTAATTTTATATCAAGGTATTGGCTGCCAGGGGGTCATCCCTAAGGGGCCT GAAGATGACAAAGGGAATAACAGCACGGGATGTTGGCAAAGATGCTTCTAGGCTAGAGA

TCAGNGGGGGGGAGAGAACTGCAGAAATCACCAACCAGAACTGCAGATACGAATCTATG GGCAGGGCTGTGACTGACAGAAGAAACGAGCTGTGGTTGAAGTACATAACTCTCACAATA CCAGTCTTCCCATCTCCCTCTCATTGCANGCCTTTCTTTTGATTAGCAATTGCTAAACTTCA AACCAGGCCATCGCCCTGGATCCCAACCC >'991115a2-001.scf came from CONTIG 1 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-001.scf (77>766)

TAATTCGTGCACGAGGGCTGTACTTTATTCCTCATAGTTCCCACACAGCGCCCCGGCCAGT AAGTATGTTCCGGGAAAGGCCTGTGGAGGAAGGCCAGATATTCAATTGCAAATGTGGGGC

AGCCCACAAGGGTGGGGCCCAAGAAAGATTTGAAGGCCACGAGAGAAAGAAAAGCCAAG GATGAACCAGACTTTTGATCGGTTACAAAAGTCATGTAAGGGCAAGGGAAAATGGAGGA ACAAGACTAATTCAAGATTGGAAGTTTAAAGAAACTTTCAAAAGGGCAAGCTTCTCCTTG AAAGGCTTCTTCCCCAAGAAAGCCCCTTGCTTGCTAAGGGGGGCAGCCTGCAAGTAGCTG CTTGCTGGCTGCTGGCCAAGGTTCCCAGCAAAAAAAGATCACCACTGAAGGTAAAGAAGG

CTCCAGCCCAGAAGGCCTCCTGGCCACAAAGCTGCAGGCCAGAAGGCAGCACCTCCTCCT AAAACTCAAAAGGGGCCAAAAGCTTCTTCCCAAAAGCCACCTGCTCAAAGCATTGGGAAG AAAGCATGAGGCATAAGAGGTTTTTAAATAAAATAAAGTTTTTTTGACTGGTGGAAAATT AAAAAAAAAAAAAAGGGGGCCGGACCCAATGCCCTTTAGGAGGGATTAATTAACGGCGG GTTTTAACGGGGATGGAAAACCGGGGACCCAC

>'991115a2-004.scf came from CONTIG 2 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-004.scf (76>690)

CTTCATCCTGGACCATGGCAAAGACGGAAAGATCTTTGTCTGGAAAGGCAGGCAGGCCAA CACCGAGGAGAGGAAGGCCGCCCTCAAAACAGCGTCCGACTTCATCTCCAAGATGGACTA

CCCCAGGCAGACCCAGGTCTCTGTCCTGCCCGAGGGCGGCGAGACCCCGCTGTTCAAACA GTTCTTCAAGAACTGGCGGGACCCAGACCAGNACGGACGGCCCGGGCCTGAGCTATCTCT CCAGCCACATTGCCAACGTGGAGCGCGTGCCCTTCGACGCGGCCACCCTGCACACCTCCA CTGCCATGGCTGCCCAGCACGGCATGGATGATGACGGCAGAAGGCAGAGCAGATCTGGA GATAGAAGTTCCGACAAAGGCCCGGGGACCCGCCAGTACGGACGTCTACGGTGGGACAG

CTACATATTTTGTCACTACCCCACGGGGGCTCAGGACAGATAATTACATGCAGGCGCCATC CACCAGATGAGGGCTGCCGGCCATCGACGTTATTGACAAGAGTGGAGAATCCCGGCAACC GGGGCCAGGAAGACCCCTCACCTTGACGTTGGGAAACCATAAATTAGGGGGCCCCCCGGG GGGAAAGCCCCCCCCC

>'991115a2-005.scf came from CONTIG 3 at offset 0;"EΛSEQUENCE\export\EST_db\991115a2\991115a2-005.scf (76>582)

CAAGAAGGGGAATGCCGAGGGAAGCAGTGATGAGGAAGGGAAGTTAGTCATTGACGAGC CAACCAAGGAGAAGAATGAGAAGGGAGCGCTGAAGAGGAGAGCGGGAGACCTACTGGA GGACTCCCCCAAACGCCCCAAGGAAGCAGAAGACCTTGAAGGGGAGGAGAAAGAGGGGG

CCACCTTGGAGGGTGAGAGGCCCCTTCCAGTGGAGGCGGAGAAGAACAGTACCCCGTCTG AGCCCGGCTCTGGCCGCGGGCCTCCTCAGGAGGAAGAAGAGGAGGAAGAAGAGGAAGAG GCTGCCAAGGAAGACGCCGAGGCCCCGGCCTGAGAGTCACGAGAGCCTGTAGCCACCAA GTTTCAAGAGGAGCCCCTGCCCCGTTCCTGCTGTGTCTGGGGCTACTGGGAAACTGGCCTG GCCTCCAACTGGGAACCCTTCCCCACCCAACCACTCTTCTTTTCCACTCTCCCCTTTGACTA

CACCTGAAATGACCCCGAGGGCAGCACGGG

>'991115a2-006.scf came from CONTIG 4 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-006.scf (76>588) CATCCTCTTCCTCTCTGTCTCACGTGTGCTCTTTTTCTTTCTACCAGTGTTATATATTTTAGC

AGCATCTAACTCAACATTGATTTCTGCATTTCTTGCTAATGCACCTTTAGAAGATACTAGT CTTGGGACAGGATCATTTTGGCCTCATTCCTTTACCACCCCTACACCTAAGAAGCATATTT TGCCAGAAAAATTAATGTAAGAAGCTTTCAGTATTAGTGATATCATCTGTCACTGTAGGTC ATACAATCCTTTTTTAAAGTACTTGGTATTTC TTCTCAAAGTTCATTCCCCAAAGGGCCCTACTGTACTTCCTGCAGNGCCCCTAGCCCAGAG

CCCATGGCTTTGATCCCTCCATCCCCTTGTCTTTGCTGACCTTGGGAATCTTAGTGCATCGC TGGTATTATATGACACTTTCTGGGGAGTGCCCTAATTGCTAAATCAAACTGGATTATGGGC AANCAGCGGCTTAAGAAGAA >'991115a2-007.scf came from CONTIG 5 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-007.scf (76>592)

CTGTGGTTAAGCGAGAGAAGCGTTGGTCAACTGCCACTCGAATCACGGAGACAGGAAGTC CCTGCCATGCCTCACATCGACAACGACGTCAAACTGGATTTCAAGGATGTCCTGTTGAGGC CCAAACGCAGTACCCTTAAGTCTCGAAGTGAGGTGGATCTCACAAGATCCTTTGCCTTTTC GAACTCAAAGCAGATGTACACTGGGATCCCCATTATTGCTGCCAATATGGATACTGTGGG CACCTTTGAGATGGCCAAGGTCCTCTGTAGTTTCTCCCTCTTCACTGCTGTCGATAAACACT ACAGCCTCGAGCAGNGGAAAGAGTTTGCCAGCCAGATCCTGACTGTCTTGAGCATCTGGC TGCCAGCTCAGGCACAGGCTCTTTCGACTTTGAGCAGCTGGACAGATCCTGAACGCTATTC CCCAGNGGAGAATGTATGGCGGGAGCGGGCCAAAGGCTACTCTGTACACTTTTGTATTTG

TGAAGGAGTGCGGAAGCGCTTCCTGACACACC

>'991115a2-008.scf came from CONTIG 6 at offset 0;"E:\SEQUENCE\exρort\EST_db\991115a2\991115a2-008.scf (82>410) GCACGGGGGCTAGCTGATGCGCTCAAGGAGAACGACCCTTCCAGCGTGCTTCTCTTCCTCG

TGGGGTTCCAAGAAGGACCTGAGTACTCCTGCTCAGTATATACTGATGGAGAAAGATGCA CTCAAGGTGGCCCAAGAGATGAAGGCTGAGTATTGGGCAGGCTCATCTCTCACTGGTGAA AATGTCCAGGAGTTCΓΓCTTTCGTGTGGCGGCGCTGACCTTTGAGGTCAACGTGCTGGCTG AGCTGGAGAAATCGGGATCCCGGCGCATAGGGGATGTTGTTCGCATCAACAGTGATGACA GCAACCTCTACCTAACTGCCCAGAAGA

>'991115a2-009.scf came from CONTIG 7 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-009.scf(82>751)

GCACGAGGCTGGGCCTCCTACGCCGGTGCAGGGCCAAGTCTCGGCCGACTTACAACAAGG TAGCTGTCACAAGGGCGGGGTTACCCTCGGGTTCCTGTGCGGGTTCATTCCCCCCAAAAGA

GTCCATGGGACCAGACCACAAGGCTCTCCCAGGGGACCAAGGGGGAAGGGACCGGGATC CCAGGGTGTGGGATTGCCAAAACAACCCGGGGGATGGCTTCAAGGAACAAGCGCCCATG CCTGGAAATAACCTGGAAAATCGCCCCAAGGACCCTGGAAAATGTACTGGGGATCAAACT ATTTTCGAGAATAATAAAAATAAAAAAAGGAAACAGAATCTTTTGGGCTTGGGCGTTTGA TTGCCCTTTGGACTTAAATATTTTTTGTAAAAAAGAAAAATAAAATTGACCCCCAAAGATT

GGTCTTTCCCATGGTAGCGAAGATTAAGGAACATCTTTTTTTAATGACAAAAAAATTTGTT TATAAAACCCCATCAAACAAAAAAGACTTCCTTGATTTTGTGTTCTTACCCCCCCCCCCCG GGGGATCAAAAAGCGGATCCTTGAATTTTGCTTGGGGAAACCATGAACTTGTCATGCCCC CCCGGAAGCCCCCACCCTTGAGGGGCACAAATAAAAGCCCAACCCGGAGGAAAAAACCA CAAAACCGG

>'9911'15a2-011.scf came from CONTIG 8 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-01 l.scf (83>521)

GCACGAGGCCGTACGCTCCCTGCACTTCGGGTCTGCTTGCTCCAGCCCGCTCTGCCGCCGC CGCCGTCGCCGCCATGGGCCCAAGCTGACATTGCCCTGATTGGACTGGCTGTCATGGGCC

AGAACTTAATTTTGAACATGAATGACCATGGCTTTGTGGTCTGTGCTTTTAATAGGACAGT CTCCAAAGTTGATGACTTCTTGGCCAACGAGGGCGAAGGGACCAAGGGCTTGGTGCTCAC TCCTTGGAGGAAAGGCGGCCAAGCTGAAAAAACCACGCGGGATCATCCTCCTTGGGAAGG CGGGAGGCCGTGGATGATTATTGAGAAATGGTACCTTGCTAGAATTGGTGATATATTATG ATGGAGAAATTTGAATACGGATACAGAAAGGGGGGAGACTCAGAAAAGGAATTGTTGGG

GGGGGAAGTAGGGGGAAG

>'991115a2-015.scf came from CONTIG 9 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-015.scf (75>420) TTGAGTTCTTTCCTCACCATGTCTTCTCACAAGACTTTCAGGATCAAGCGATTCCTGGCCA

AGAAACAAAAGCAGAATCGTCCCATTCCTCAATGGATTCGAATGAAAACTGGCAATAAAA TCAGGTACAACTCCAAGAGAAGACATTGGAGAAGAACCAAGCTGGGTCTATAAGAAGCA AGCTGGGTCTATGAGAAGTGGTCTTAACATGTAGACCACTTTTTTAAGCAGCCAGATCACA ATGAAAACATCACTACTGTAATGCTTGGCCCATGATGTTATTTCCTCACTATCAGTCTGAG ACCCAGCAATAAATATAAAACGTTGCAAAAAAAAAAAAAAAAAACTCGAGGGGGGGCCC

GGAACCCAANTCGCCTATAGTGAGTCGGATTACAATTCACTGGCCGGCGGTTTACACGCG CGGGACTGGGAAAACCCTGGCGTTACCCACTTATNGCCCTGCAACACATCCCCCTTTGCCG CTGGGGNATAGGGAAAAGCCGCACCGACGCCCTCCCACAGTTGGCACCCGAAGGGGAAG GGAAATGTAGCGTTATATTTGTTATATTCGGTAATTTTGTTAATAATTCTTTTTACCAAGCG AAAGGGCAAACCTTTAAAAAAAAAAACGGAAGGTGGGGGGTCCGTGGGACAAAACCTTT

AAAAAGGGCTCCGCCGGGGAA

>'991115a2-050.scf came from CONTIG 9 at offset 326;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-050.scf (82>801) ACAAAACTGGAGCTCCACCGCGGCGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAAAGGGATTCTATCCTAATAACAGGTCTCTTCTCCCACCTTAA CGGCGCCTCCCCTCAGCACCCACCTGTCCCCTCTCCGCAGTTTGCATATAGGAACGTGGGC CATCCTGCCGTTGCGTGTACTTGCGGGCTCAAACCACCTTCGTGGGGAACCCATTGTATTG CCAGGGGCTGAAGCAAAGTAGCCCCTCCCTTTCCTCCACTGATGCCCAACAAGAACCTCC

CTCCAGTCTCAGTCACTCTTGTTTTCTATGGAAGGGAAAAGGTTTGGTCTACCTAACAAGT AGGCATTGCGAATGGGCCAGTATATTCCAGTCCTTTAGGCAAAAGGAAAATGCATTCTAC CTTCTCCTGCCCCCTCCTTCCTTTTAAACAAAAAAGGAGATACAACCTCCTGTGCCAAAGT AATGGGTCCATTCAGAAGGTGGAGAAGCATCATCCGTTGGTTAGCTATTGAGGTTAGGAC CACTGACCCTCCCGGGGAAGGATGCAATGATTTGTGACAGTCCTCAGAAAATTTGATATG

CAGATGAGGCCGAAATTTTCTCATAGGTATTATTGACTAAGAGATAAATTTTTTTATCTTG GGCGGTGTTCTTAATTTGACGGGCGGTGGCTCCCACCAACCTTTTTTTCTTTTGGGTTTTAC CAAAAAGGTTTAAACCCAAGTTTTTTTTITCAAACCCTTTCTTACTT^^ >'991115a2-016.scf came from CONTIG 10 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-016.scf (76>673)

TAAGAAGATGCCTGCACACAAGACTAAAAGTTCAGTGATCTTATGCCCAGATGGACAGTC CCAGGCCCGGTGGTTCTACCTGCTGCAAGCTGCCCACTGGAAAGTATGGCTGCTGCCCGAT GCCCAATGCCATTTGCTGCTCCGACCACCTGCACTGCTGCCCCCAGAACACTGTGTGTGAC CTGACCCAGAGTAAGTGCCTCTCCAAGGAGAACGCTACGGACCTCCTCACCAAGCTGCCC

GCACACACAGTGCAGGATGTCAAGTGCGACATGGAGGTGAGCTGCCCAGACGACTACACC TGCTGCCGCCTACAGTCCGGGGCCTGGGGCTGCTGCCCTTTTGTGCAGGCCGTGGGCTTGG AGGACCATGTGCACTGCTGGCCGTCCGGTTTAGGTGTGACACAGAGATGGTGGGTGTGAG CAGGGGACCCGCCAGTGCCGGGATGAAGAAGCCCCACCACCTCACCCGCGGACCTCGAA GCGCGGGGGGGAGCCCCTGGATAACGCACAGTGTCTTTTTCCTACTGTGCGATTAAGCGG

GAGGGCCTGTGCCTGTCCAAGTGCTGCTGTCGACCCCCCTGTGCCAAGGCTACGGG

>'991115a2-018.scf came from CONTIG 11 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-018.scf (82>549) GCACGAGCTGGGTCGGCAGCGGCAAGACTGTTTGGCCGCCTCTACAAGGTCCCGGCCATG

TTCAGCTCCAGTGCCAAGATTGTCAAGCCCAACGGCGAGAAGCCGGACGAGTTCGAGTCG GGGATCTCCCAGGCCCTGCTGGAGCTGGAGATGAACTCGGACCTCAAGGCGCAGCTGCGG GAGCTGAACATCACGGCCGCCAAGGAGATCGAAGTTGGCGGTGGCCGGAAAGCTATTATT ATCTTCGTCCCCGTCCCGCAGCTGAAGTCTTTCCAGAAAATCCAGTGCGCCTGGGCGCGAG CTGGAGAAGAAGTTTAGGGGAGCACGTCGTTTTATTGCCCAGAGTATAATCTGGCTAAAC

CACTCGAAAAACCCGACGAAAATAACAAAACGTCCCAGACCGCACTTGACGCTGGCACCA CCCCTTTGTAGATTGGTTTCCAGGAAATGGGGAAAAGATCGGGGAGT

>'991115a2-019.scf came from CONTIG 12 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-019.scf (77>614)

GACAGTTCATAGTGGTGAGAAACCTTACAAATGTGATGAATGCGGCAAGGCCTTTCCTAT AAAGTCAACCCTTTCACAGCATCAGACAATTCATACTGGTGAGAAACCTTACAAATGTGA TGAGTGTGGCAAGGCCTTTCGTTTAAAGGCAGTCCTTTTAAAGCATCAGACAATTCATACT GGACAGAAACCTTACAAATGTGACGAGTGTGGCAAGGCCTTTCGTGTAAAGTCAACCGTT TTAAGTCATCAGGCAGTTCATACTGGTGAGAAACCTTACAAATGTGATGAGTGGGGAAGA

GTCTTCCGTAAAAAACCACAGCTTCCACGTCACTGCAGAATTCATACTGGAGAGAACCTTT TATATGTAAGAATGGGGCAGTTCTTCAGTCAAATTCACACCTTATAGACATCGAGATACTA TAGAAAAACTTCAATGTTTGAGGGGGAAAATCTTTATCAGGCACACACTCCTAAAATAAA AATCCATACTATAAAAAATATGGAGTGGATTAAANAAATTTAATTCAAGTGAAAG

>'991115a2-021.scf came from CONTIG 13 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-021.scf (76>670)

TTCCCAGGTGCTGCTGGCCGAGTCGGTCCCCCCGGCCCCTCTGGAAATGCTGGACCCCCTG GCCCTCCTGGCCCTGCTGGCAAAGAAGGCAGCAAAGGCCCCCGCGGTGAGACTGGCCCCG CTGGGCGTCCCGGTGAAGTCGGTCCCCCTGGTCCCCCTGGCCCCGCTGGTGAGAAAGGAG

CCCCTGGTGCTGACGGACCTGCTGGAGCTCCTGGCACTCCTGGACCTCAAGGTATTGCTGG ACAGCGTGGTGTGGTCGGCCTGCCTGGTCAGAGAGGAGAAAAGAGCTTCCCTGGTCTTCC TGGCCCCTCTGGTGAACCCCGCAAACAAGTTCCTTCTGGAGCAAGTGGTGAACGTGGCCC CCCTGTTCCCATGGCCCCCCTGGATTGGGTGGACCCCCTGGCGAGTCTGGACGTGAGGGA GCTCCTGGTGCTGAAAGATCCCCTGGACGAAATGGTTCTCCTGCCGCAAGGGTGACCGGG GGGAGAACGGCCCTGCTGGACTCCTGTGCTCTGGCGCTCCCGCGCCCCCGCCCTGTGGGA CTGCCGGCAAGACGGGGATGGGGGAGAACGCCCTGTGGTCTGTGTCCCATTGC >'991115a2-084.scf came from CONTIG 13 at offset

380;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-084.scf (78>522)

CCTGGATTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGCTCCTGGTGCTGAAGGA TCCCCTGGACGAGATGGTTCTCCTGGCGCCAAGGGTGACCGTGGTGAGACCGGCCCTGCT GGACCTCCTGGTGCTCCTGGCGCTCCCGGTGCCCCCGGCCCTGTCGGACCTGCCGGNCAGA GCGGTGATCGTGGTGAGACCGGTCCTGCTGGTCCTGCTGGTCCCATTGGCCCCGTTGGTGC

CCGTGGCCCCGCTGGACCCCAAGGCCCCCCGGGGGACAAGGGTGAGAACAGCGAACAGG GCGACAGAGGCATTAAGGGTCACCGGGGCTTCTCTGGTCTCCAGGGCCCCCCGCCCCTCC CGGCTTCCTGTGAGCAAGCCTTTCGGAGCTCTGTCCTGCTGGCCCGCGGCCCCCCTGGCTT TGTGTTTTCCCGAAAAATGACTC

>'991115a2-056.scf came from CONTIG 13 at offset 499;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-056.scf (76>528)

TGGACCTCCTGGTGCTCCTGGCGNCTCCCGGTGCCCCCGGCCCTGTCGGACCTGCCGGCAA GAGCGGTGGATCGTGGTGGAGACCGGTCCTGCTTGGTCCTGCTGGTCCCATTGGCCCCGTT GGTGCCCGTGGCCCCGCTGGACCCCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCGA

ACAGGGCGACAGAGGCATTAAGGGTCACCGTGGCTTTTCTGGTCTCCAGGGTCCCCCCGG CCCTCCCGGCTCTCCTGGTGAGCAAGGGTCCTTCCCGAGCCTCTGGTCCTGCTGTTCCCCG CGGTCCCCCTGGCTCTGCTGGTTCTCCCGGCAAAGATGGACTCAATGGTCTCCCAAGCCCC ATCGNTCCCCCTGGGCCTGAGTCGCACTGGTGATGCTGTTCCTGCTGGTCCTCCCGCCCTC CTGGACCCCCTGGGCCCCAGNCCCTCCAG

>'991115a2-085.scf came from CONTIG 13 at offset

580;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-085.scf (83>661)

GCACGAGGGCTGGTCCTGCTGGTCCCATTGGCCCCGTTGGTGCCCGTGGCCCCGCTGGACC CCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCGAACAGGGCGACAGAGGCATTAAGG

GTCACCGTGGCTTCTCTGGTCTCCAGGGTCCCCCCGGCCCTCCCGGCTCTCCTGGTGAGCA AGGTCCTTCCGGAGCCTCTGGTCCTGCTGGTCCCCGCGGTCCCCCTGGCTCTGCTGGTTCTC CCGGCAAAGATGGACTCAATGGTCTCCCAGGCCCCATCGGTCCCCCTGGGCCCTCGAGGT CGCATTGGTGATGCTGGTCCTGCTGGTCCTCCCGGCCCTCCTGGACCCCCGGCCCCCCAGT CCCTCCCAGCGGCGGCTACGACTGAGCTCCTGCCCCACCACCTCAAGAAAAGCTCAGATG

GTGGCCGCTATACGGCTGATGATGCCAAGGGCCGGGCACGGGACCTAAGGGGAACCACC CTAAACCTGACCACAAAAGAAACACCGAACCCGAGGCACCGCAAACCCGCCCCCCCGCC GGACTAAAAGCCCTTTTCGGAAAGAAAAATGATTGCC >'991115a2-090.scf came from CONTIG 13 at offset

624;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-090.scf (84>340)

GCACGAGGCTTGGACCCCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCGAACAGGGC GACAGAGGCATTAAGGGTCACCGTGGGCTTCTCTGGTCTCCAGGNGTCCCCCCGGCCCTCC CGGCTCTCCTGGTGAGCAAGGTCCTTTCCGAGCCTTTGGTCCTGCTTGTCCCCGCGGTCCC CCTGGCTCTGCTTGTTCTTCCGGCAAAGATGGACTCAATGGTCTTCCAGGCCCCATCGGTC

CCCCTGGGCTTGGAG

>'991115a2-022.scf came from CONTIG 14 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-022.scf (83>568) GCACGAGGGCCCAGAACGTGCTGTCGAAGGCGGACGTGATCCAGGCCACCGGAGACGCC

ATCTGCATCTTCCGGGAGCTGCAGTGTCTGACGCCCCGAGGCCGCTACGACATCCGCATCT ACCCCACCTTCCTGCACCTGCACGGGAAGACCTTCGACTACAAGATCCCCTACACCACGGT GCTGCGGCTCTTCCTGCTGCCCCACAAGGACCAGCGCCAGATGTTCTTTGTGATCAGCCTG GACCCCCCCATCAAGCAGGGTCAGACTCGCTACCACTTTCTCATCCTGCTCTTTCTCCAGG ACGAGGACATCTCCCTGACGCTCAACATGAACGAGGAGGAGGTGGGAGAAGGCTTTGAG

GGCGGGTCACCAAGACATGTCAGGATCCCTCTCGAGAGGGCAGCCGGTCATGAAAGGCTG GTGACCGCAGATCAGGGCCCGCCATTTTCAAGGCACTGGGGGCCAGGCATCACTGTCCAC AGGC >'991115a2-023.scf came from CONTIG 15 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-023.scf(82>608)

GCACGAGCGCTGGGCCGCCGCCATGTCTCTAGTAATCCCTGAGAAGTTCCAGCACATCTTG CGAGTACTCAACACCAACATCGATGGGCGGCGGAAAATTGCCTTTGCCATCACTGCAATT AAGGGTGTGGGGCGAAGATATGCTCATGTGGTGGTGAGGAAAGCAGACATCGACCTCACC

AAGAGGGCCGGGGAGCTCACCGAGGATGAGGTGGAACGTGTGATCACCATTATGCAGAA TCCACGCCAATACAAGATCCCAGACTGGTTCTTAAACAGACAGAAGGACGTGAAGGACGG GAAATACAGCCAGGTCCTGGCCAACGGTCTAGACAACAAACTCCGTGAAGACCTGCAGCG CCTGAAGAAGATTGGGCCCACAGGGGCTGCGCCACTTCTGGGACTCCGGTCCGAGCCAGC CACCAAGACACAGCCGCCGGGGCGCACTGGGGGGGCCAGAAGAAAATGGTGGCTTGGTT

ATAAATATTATAAGTAAAAAAAAAAAAAATGAGGGGGCCCCACCATTC

>'991115a2-024.scf came from CONTIG 16 at offset 0;"E:\SEQUENCE\export EST_db\991115a2\991115a2-024.scf (76>606) CGGCGGCGAGATGTCCGGAGGATCAGCTAGGAGCCTGGGCAAGGGAAGCGCCCCCCCGG

GGCCCGTCCCCGAGGGGCCTGATCCGTGTCTACAGCATGAGGTTCTGCCCGTATGCCCAG AGGACTCGCCTGGTCCTGACGGCCAAGGGTATCCGGCATGAAGTCATCAACATCAACCTG AAAAATAAGCCTGAGTGGTTTTTCAAGAAGAATCCCTCAGGCCTGGTGCCGGTTCTGGAA ACCAGTCAGGGTCAATTGATCTGTGAATCTGCCATCACTTGTGAGTACCTGGATGAAGCAT ATCCAGNGAAGAAGCTGTTGCCAGGCGACCCCTATGAGAAAGCTTGCCAAAAGAGGTCTT

GGAGTCCTTTTCTAAGTACCACCTTTGATATTGAGATCTTATATACAAAATAAGAAGATGC TCTGGCTAAAGAAAAATGATAAAGAATACCAACTAAGNAGGTCTGATGAAAGAAAAAAC TTCTTGTGGCATTTTTTTTTTATGATACTATTGCCCTGGTGAAGCTGGAGC >'991115a2-025.scf came from CONTIG 17 at offset

0; "E:\SEQUENCE\export\EST_db\991115a2\991115a2-025.scf (77>511)

CGCCGGGGGGCCATGGGACGGNGGCCGCTGATGGGAAGGGGCCGCGTGTGTTTTTGCAGA AGTCAGCGGTTTCGGGGACCCAAAAGATGGGAGGGAAGAAACCTGGNGGCGGNGTCTTC TTATCCCGGGCCCAGTCNCCCCCACGGTGGTNCGCGGCGGGCTTCGAGTGTCTTTTGTACC ACAAAGAGGGTCTTAGCTCTTGGAGGGTGGGGCGAGGGGGAGGCTCGCGGCCGCGCTGG

GACTGGCAAGGGTGGGATCCCGTCTGGGGCAGAGTGTGTGGAGGCGTGGGCCCCCCGTGG GGCAGAGGGAGAAGCCCCCCCCTGTAGCCTGGGCGGCCCGCAGCCTTTTCTGCCTTGGAT ACCCGCACAACAGATCCCCACTTTGCTGTGCGGGGCGACGCGGCCCGGCCCACGGCAGAC CTGGGTGGCAACAGCT

>'991115a2-026.scf came from CONTIG 18 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-026.scf (83>640)

GCACGAGGTTTTTTTTTAAAAAACAAATAAAAGGTTTATTCATAAGCAGGAATGCTGTCCA GAATACATACAGTGCAAACTCTCCTTGTCCTTGGGATCAACACAAGCCCACAAGCCAGGA AAATTGTTATCAGTTAGGTCAAATGGACTCCCCCCAGCACTTGGGCCCTAGCCTGGCCAAG

GCCCCCTTCCTTGGCAGAGAAGGTTCTTTTTCTGTTTGGGTTCACACAACCAAACCCAAAA TGGAAGCTGAGATTAGAGCAGCACAAGCTTTATTCATTGGTCAGAGAATGGAGAAGTGGG AACTTATTAACCGTTGATAAACAAACTTCTCGCCTTAATGTGGAGCCAGATTTGCTGTTAA GAGCATGNGGGAAAGAGTGCGAGAATGGGGGGGAGCAAAGCTCTCGTTTCTGGGAAGAG CAGGGTTTCCTTAATGAGNGCCACTTTTTTGCCTTTTTNTCAGGATTCTGTCACGA^

GNNANCATTATACTATGAGAGTTAGTCATCACCGTAGCTGTCGATTTGGACCCAGATGAC AGCAGCTCCGTCTC

>'991115a2-027.scf came from CONTIG 19 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-027.scf(76>628)

CTATTCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATTTGGTGCTTGGGCCG GTATAGTAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAATTAGGCCAACCCGGAACTCT GCTCGGAGACGACCAAATCTACAACGTAGTTGTAACCGCACACGCATTTGTAATAATCTTC TTCATAGTAATACCAATCATAATTGGAGGATTCGGTAACTGACTTGTTCCCCTAATAATTG GTGCTCCCGATATAGCATTTCCCCGAATAAATAATATAAGCTTCTGACTCCTCCCTCCCTC

ATTCCTACTACTCCTCGCATCCTCTATAGTTGAAGCTGGGGCAGGAACAGGCTGAACCGTG TACCCCTCCCTANCAGGCAACCTAGCCCATGCAGGAGCTTCAGTAGATCTAACCATTTTCT CTTACACTTTACAGAGTTTCTCATTTTAGGACCATCAACTTATTACACAATATTAAATAAG CCCCCGCATGGACATACCAAAACCTTGTGTTGATCGTATATTACGCGTACTATACACCTCG TCCT

>'991115a2-043.scf came from CONTIG 19 at offset 4;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-043.scf (73>538)

TCTCAACCAACCATAAAGATATTGGTACCCTTTATCTACTATTTGGTGCTTGGGCCGGTAT AGTAGAGAACAGCTCTATAGCCTTCTAATTTTGCGCCTGAATTAAGCCCAACCCGGAACTC TGCTTCGGGAAACGACCCAATTCTACAACGTGAATTGTTAACCGCACACGCCTTTGTAATA ATCTTCTTTATATTAAATACCAATCATTAATTGGAGGATTTGGGTAACTGACTTGTTCCCCT TATAATTGGTGCTTCCGATATTATATTTCCCCCAATAAATAATATTAACTTTTGACTCCTCC

CTCCCTCTTTCCTACTACTCCTGCCTTCCTTTTTTTTGTAACTGGGGCCAGAACAGGTGAAC GCGTACCCCTCCCTTACAGGCAACCTACCCTTGCAGGAACTTTATAGATTTAACCTTTTTTT TTCTCTTATAAGATTTCTTTTTTTTTGAACATTCA >'991115a2-028.scf came from CONTIG 20 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-028.scf (82>595)

GCACGAGGTTAAGTTAAATATAATTGAGATAAGAGTTTTGGGAGTTGAGCTCTTTGGGAA TAACTGTTTTAGGAAATCTACTTAAAAAAAGTCTCTCCAGATTTTGGCAACTTGAAAGTTT TGTTAAGTTAAATAATGGGGAGTCACTGTCTGAATTGCTAATTGCTAAACAAGTCTAAGTT CACCCCCCTTTTTTATGAGAGAAAAACTAAATATGTTTGGGTTTGTTAGAAACATATGACA

CCACACTGAGGACAGAAGTTATTCGATGAGATGACGTGTGTTTCTGAAGACTGTAGAAAC ATAAGTTTCCAATCAGGAAGCCCTGGTATGATCACAAGTCCTTGCTTCTGTTTTGCTGGAG ATCAGGGTTCTTAAGGCTGTGTTGTTTAGTGCTCGGCACCTCCGATCTTTTGNGACCCATG GACGTACCCCCCAGGCTCTCTGCCATANATTCTCAGGCAGAAACTGAAGGGTGCCGTTCCT TTGCGGGGACTCCCCCCCAGGTCCACAG

>'991115a2-030.scf came from CONTIG 21 at offset

0;"E:\SEQUENCE\e port\EST_db\991115a2\991115a2-030.scf (76>661)

TTTGGAGATACATGGAAGCTTTACTGGACAGGGTGGAGGGGCTGCCAGCGGGGGGCGGG GGGCAATGCAGGCAGGGCAGGGGTTGTGGCTCTTGACCTGGAGACCCCGGCACGTGGCCG

CTCCCAGCACTGACGGCGCCTTCCCTGGGAGCTTGCGGCTTCTCTGGAGGGCGTCCCTTCA CCAACCAACAGCCAGAGTTCCTCTCCTCCTGGAACTGTGGGGGGCAGTGAGTGCCATGTT GGAGGGCGAGGTCGGAGGGCCCCGCAGCAAGAGCTGCCAGGGTTTCGGNGCGAAGGCAG GCGTGAGAAGCAGCTTCTTTCGCAAGGTCGGNTTCGGGGGGCGGNGGGCGGATCTGGCCG GGTTCTCCCCTGGGGCGGCGGACGGGGAAAGCAGACCTGCTGCTGNCTTGCCCNTGCTCC

TGGAAAGAGAAGAGAGCCTATGCGCCGAGCCTCGTCCACAGCACTTCTTGTATTCCGTGT CCGCGGCCCAAACTGTACCTCTCCCAACGGGTGCTTTGACGTAAACAAATTTGGGCCTCCT TTGTTTCCAAAACCGTTGTTATGTTCGCCCCATATCTTGAGGCGGA >'991115a2-031.scf came from CONTIG 22 at offset

0; "E:\SEQUENCE\export EST db\991115a2\991115a2-031.scf (82>699)

GCACGAGGGCGGGCGCTTTTTCTGCCCGCGGTGTCTCAGATTCATTCTTAATGGAACTGAG AACTTAATCTTCCAAAATGTCAAAAAGACCATCTTATGCCCCACCTCCCACCCCAGCTCCT GCAACACAAATGCCCAGCACACCAGGGTTTGTGGGATACAATCCATACAGTCATCTCGCC TACAACAACTACAGGCTGGGAGGGAACCCGGGCACCAACAGCCGGGTCACGGCGTCCTCT

GGTATCACGATTCCAAAACCCCCAAAGCCACCAGATAAGCCGCTGATGCCCTACATGAGG TACAGCAGAAAGGGCTGGGACCAAATAAAGGCTTCCAACCCTGACCTAAAGTTGTGGGNA GATTGCCAAGATATTGTGGGATGTGCGAGATCTCACTGATGAAAAAAAAAAATATTTAAC GAAAACCAGCAAAAAGATGATACNATGATCTATGAGGCCTACATAATCCCCCGCACCTGC TACTAAAGCAAAGAGCGCAGAGCGCTTTAAGAAAAAAAGAAGAAACGCGGCTGAGAAGA

GACCTACTGAATCACCGCTGAACCAAAATTTNAGAGTTTTATGAAAAAACCCGCCCTCCA AAAACCCCCCAGAACCT

>'991115a2-032.scf came from CONTIG 23 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-032.scf (83>484)

GCACGAGGCAGTCCCTAATTGAGGAACTAAGATCCTACAAACTGTGGGGTGAGGCCTAAG AAAAAAAAGAAAAAAAAATGGGTGGTCAAGGAGGGCCCTTTCTGAGGGAGTGACATTTA CGCAGAGATGTGAACAAAGTGAGGGTTTTTCCTGGGGAAACACTTGCCAGGCACAAGTGT GATCATGCTTAACATGTTCGCTAGCAAGGACTGTAGGGGAATATTTATGAGGAACGCATG TGCCACAAGAACAGAGATCCTGTTCACCTATAATGCCTTGAGCAGACCTGGCATGTACCCT

CAACAATACTTGTTGAATGAATGGATGGGCAGATAGATGGATTTTAATGAATGAGCAATA

ATGATACATTCTCCCAATAACCTGGAGCCAGAAGAGAGGAGA >'991115a2-033.scf came from CONTIG 24 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-033.scf(76>595)

CTCACCTGCCACCTATGGGCCACCTGAAGCAGTGCCACGGCCAGGAGGAAGCTGGCAGGC GCAAATTGTGGTCAGCCCCTGCTGGGCTGCTGCGGGGGGACAGGTCCTCGCCTCTGCTGA GTCCGCTGAAAGCCCCAGACTCCCTGCCCCAGGGGACTCCACTGGCAGCCAGCCTCTCTG CAGCCTCCCTAACACCCTTATGTGTCTCAAAAGAGGGGAAGTGCCCTCTGTTCAATGCCCC

CAGCCATGCCCAGAGCTCAAGCCAAGCTCCTGCAGGGACTGGCGTGCCCTCCCCAGGCCC CACGTGCATGGACGCTTCCTTAGTGCGTGCCCGCTCCTTGCTGAAGGCTACAGAGAAGAG GGGNCCTAATCAGGCCTGGTGAATGCCTGCCCCTGGAAGCCGCCAGGCTGCAGAGTTCCA GAGACTCTGGGACTTTGAGAGAAGNTTTCAAACCCAGCCTACAGGGACGACGCCCCACTC CTTGCTGGCCCGGCTCACCCTCCCAGGAGGGGGCTCCGG

>'991115a2-034.scf came from CONTIG 25 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-034.scf (75>554)

TGGACGCACTCGGGAATTGTAGAAGGACGAGGCTCAGCTCTTGCCAGGCCGACTTGAGAC ATGTCTGACACAAGCGAGAGTGGTACGGGTCCAACCCGCTTTCAGGCTGAAGCTTCAGAA

GAGGACCCTGGCTTGAAGATGCAGACCGGACTGACAGGGACCCAGAACTTAAAGGCCTC AGAAACACCGAAAGGCTCAAAGACACCAGAGGGCTCAAAGGCCACGAAGATCTCAAATG CTGCAGGCGTCTCAAAGGCCACTGAAGCTCAGGAGGTATCTGCCACTCAGGCTTCACCTA CCACTAAACTGACCGATACCCAGTTTCTAGCAACCAAAAGAAGAGTCTGGCAGTTGACAC CAAATGCAGCATACTGACCCTTAGGCTGTGAAATGCCTGGTTATGAAACCAAAAGGTAGT

TTGGGTTGATACCAAGGTCATACAAAACCCTGGAAATGAATTTACTGCTTTAGCTTTGGCG A

>'991115a2-035.scf came from CONTIG 26 at offset 0; "E:\SEQUENCE\export\EST_db\991115a2\991115a2-035.scf (82>672)

GCACGAGGAGAGAACTGCCACAGGGGATTTGCACGGGTAAGTGCTATATATGTGAGGTAC CTACATGGCTGAATAAAACCAATTGTATGAAATCATTTATGCAAAATGGAAAGGGTGATT GGGGTGAAAATCTGAAGGAGAGATTGCTCGCTGTAAGCAGCTCATCTGCGATCCCAGCTA TGTGAAAGATCGAGAAGAATAAGTGGGCCAGGTGATCAGAGTCATCTGTATTCTCAGCCA CCCCCATCAAAACACCAATGACGCCCACTCCTGCCAGATCATTATTCCACAGACCCAAGTC

AACCGGAAGTCAGATATCTACGTCTGCATGATCTCCTCTGCACACATGTGGCCGAACAGG CAGAACATCGCCATTGCCACACAAAGGNGGAACCAAGAGGCCGAAAGGAAACAAACAAC CTGGGCTTTTGGACCAATGAACAGAATTCGTAGATCAGGACCTCCTGACCAAAGATGGGA AAAAAGCAAACTTTTTCGCACTTAAGCACATCCTTTAAACACTGGAGACATAGAATTATA AGAAGAGGACCGGNTGCTGGAAAGAAGAAAAAGAAAAAGGGAAAAAAAGAC

>'991115a2-036.scf came from CONTIG 27 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-036.scf (83>509)

GCACGAGGGCCAAGCCCTCCTCCAGGGGATCTTCCCAATCCAGGGATCAAACCAGGTCTC CTGCATTGCAGGCGTTTTCTTTACTGGCTGAGCAGGTGGGAGAAAATAAACACAAAGATT

ACTGAATGGCCACATAGGCTAAGAAATGAAATAGGTGTAGTGGGGCGGAGCGGGGCATA AAAATACACGGTGCCCGGGTTTTGGTCACTTAGTGGAGGTGCAACGGGCAGTCACTGGGC AAGATCCTGGGGTCACAGCGGGAAAGCGGGGTCCCTGCTCTCACTGACTCACGTTCTAAG GGGGGCGGGGCGGGGGGCGGGGAGGGCAGGCTGGAGGAGAGAGTTTGGGGGACCAAAA CAAGCACGGGCCAGGGCTGGCAGGATGCCTGCGAAAACGGCGGGGTGCACACCGAGCTG

GGGCCAGATCG

>'991115a2-037.scf came from CONTIG 28 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\9911 I5a2-037.scf(236>332) AACAAACCAATCATTTACAACGCTTTATCCCATTGTTGTCTCGTCAGAAAAGTGAAACGAA

CCTCACAAAAATTCAATATTATAGGAGCTGGAGAAG

>'991115a2-038.scf came from CONTIG 29 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-038.scf (75>544) CGGTGCTGTCCGGCGGGGACCACCATGTACCCCGGCATCGCGGACAGGATGCAGAAAGA GATCACTGGCCTGGCACCCAACACAATGAAGATTAAGATCATCGCGCCCCCTG-AGCGCAA GTACTCCGTGTGGGATTGGCGGGTCCATTCTGGCCTCGCTGGCCACCTTTCAGCAGATGTG GATCAGCAAGCAGAAGTACGATGAGTCCGGCCCCTCCATTGTTCACCGCAAAAGCTTTTA AGCGGACTGGTAGCTGCGTTACACCCTTTTTTTTGACAAAACCTAACTTGCGCAGAAAACG

AGATGAGATTGGATGTGTTTATTGTTTΓTTTTTTTTT^^

TGTATTAGATTTAAAAATGGACGGGAAAGAGAAGAACGGGTGGATGAGATTCCCAAATTT

TAAGGGGGCGGGACTGATTGAATGGTTGTTTTTTTTTATATATTT >'991115a2-039.scf came from CONTIG 30 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-039.scf(76>691) GCACGAGGTCGAGTTTTTTTTTTTTTTTT^^

AGAAACCAGGGACACAGCCATAAGAGAGGGAAGCACACAGGACTGCAAACTAAAACCCA ATAGCCAGCAAGGGCCCTTTGGGCCAGGAACACTGCCTCCTGGGGTCCTCACAATCTCCC ACCAACAGACACACAAGACTGGGCATCCAGGGAGGGGGGAGTGGGCTCTGGGGCCCACA

GAGTGAGAGGATATATGATGCCTCATTATGAGAGACAGGGAGGGGAGGAAAATGGGAGA GAGCCCGCCACTGCCTAAAACACCCCCTCCTCTCAGACCAAAACCAGATGGAGGACGAAC CACCTATATATTGAAACAGCTGTGGCTCTCATATTATTTGTTGCCACTGAAAAGAGCGTGC TNTGGGGGGATTTCCTTTTTTCCCCCACGCCCTTATTGGTCCACTGCCGGGGGTAAGGCAT TCATCTCCTTCGGCAGGGTTACTTATATATTTTTTTATTGGGGGGCCAGCAAGGTGGTTGC

GCCGCGCCGGCCTCCACCTCCCGACATTTATTGTATGAAAATGATAAGAAAATAAAAAAA AAAAAAAAACACGA

>'991115a2-040.scf came from CONTIG 31 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-040.scf (77>650)

GAAAAATCCCCAAACCCCCCTAAAACTGTAATCTTATGGGTGATACAGTAGCAGGACTTA GAGGAGCTTGTCTCAGTTAGAATAACCTGTGTTCTCTATAGTATACTGCTATAAGCTGTTG TTGAGTTACTAAGTTGTGTCTGACTCTGCAACCCCCGGGGACTGCAGCATGCCAGCCTTCC CTGTATTCACTGTCTCTGGGAGGCTGCTCAAACTCATGTTCATCCAACTATCCCATCCTCTG TAGGAATTATATATTATAGAATGGAATTATATATATCACATTGAAAAGTTTCAATATGTAG

GTATTTAAACTATATTAGTACTTATATATATATTATATAACCTTACTAAAATTCTGTAGATT TTTAAGATACTTTTAAGAATATAACTTGACTGAGATTTGAAGTTTGCGGGGGGCTTTCTTG GAGATTACANGTACATTATATTTTAGTGAGAAGACATAAAAAAGCCTGGTCCCAATTTTCC AACTGTTACAAGGGATTTCTTTTCCTTTTATTTTTTAATACTATACA^ GGATCTTGGAGGAGGCCAAAGGG

>'991115a2-041.scf came from CONTIG 32 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-041.scf (75>587)

CCGCTGGGAGCGCAGAGCGGCTGTGGGACGCGGAACTGCAAGAGTGCCGCCTGGCCTCGC TCCTTCCGTGTTTGCTTCTCTGCGGAGATGCCCAGCCGGGTGAGCGACCCGAGGACGGCGC

TGGGCCCGTCCCTGCTGAGAGCTCGACCCTGCACAAGGAAGAGCTCAGCAGCAAGATTAA AGAACAAAAAGTTGTTGTGGATGAACTTTCTAACCTGAAGAATACAGGAAAGTGTATAGG CAGCAACAGAACAGCAACATATTCTTTCTTGCAGACCGACAGAAAGCTTTCTGAAAGCAA AAACATTGATGAGCTGAGGAAGAATATAAGAATATAAACTCANAGAGAACAAATCAATA AAAGCCAACTGATTTACATACATGTGTGCATTGTGGCAGTAGCTTTCTGTGAGATTTACAG

AATTGAAGAGATTACTGGTATCTTAACGAGGGCCGATGTAGAAAAGTGTAGTTATGTACT ACAGTTATTTTGCCTGCCTACTATAGTGTGCT

>'991115a2-044.scf came from CONTIG 33 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-044.scf (82>635)

GCACGAGGCAGAAGCTTCCCGCAGAGCGGGGCTTGCAGCTTCTTCACAAAATAATTGATG GCATTTGTGGCCGAACTTATCCTCTCTACCAAGATTATCACAGTGTTTGGGATTCAACAGA ATGGATGCATGTTTTAGAAGACATTACCACCTTTTTCAAAGCTGTAGTTGGTAAAAATTTA TCTGATGAAGAGATATCTCAACAGTTGAATCAGGTGAATTCATCTCATCAAGAAGCTATC ATGAAATGCTTAAAAAGTAGGAAAGATGAAATCAAGAAGACTCTGTTGGGAGAAAATAG

TGATATTTCCTCTGCACGACTACGGGATTTTGATTGTCAGATAAAGCTTGCCTTTCTATGAC AGATTGCTTCATTACAATGCACTTTTAACCTTTTCTGATGTAAAAAAAATGGGAAGGAAGC CTATCTGTTGAAGAGAAAGAGAACGCACAGCTATTAATCCTGGAGCGCTATAGGGGGCTG CGCTAAAAACGAAAGAGATACACATTCAATTCACGGCACGAGCCAGAAGAACAGGTCCG . AAACGATGCCA

>'991115a2-046.scf came from CONTIG 34 at offset 0; "E:\SEQUENCE\export\EST_db\991115a2\991115a2-046.scf (83>697)

GCACGAGGCTTTTGAAGATTCTTCGTTGTCAAGCCGCCAAATGGAGAGTGCGATCGCAGA AGGGGTGCTTCTCGTTTCAGTGCTTCTTCGGGCGGAGGAGGAAGTAGGGGTGCACCTCAG CACTATCCCAAGACTGCTGGCAACAGCGAGGTCCTGGGGAAAACCCCAGGGCAAAACGCT CAGAAATGGATTCCTGCACGAAGCACTAGACGAGATGACAACTCCGCAGCAAACAACTCC GCAAGTGAAAAAGAACGACATGATGCAATCTTCAGGAAAGTAAGAGCATATTAAACAAG

CTTACTCCTGAGAAGTTTGACAAGCTATGCCTGAGCTCCTCATGTGGGTGTAGAGTCTAAA CTCATCTTAAGGGGGCATACTGCTGATTGGGGACAAGCCCTAAAGAGCAAAGATAGCTAC TTATGCTAACTATGCTGGATGGCAGAGAGCACAAACTTTGAGGCCAAAACAAAGGCAACA GAAAAAACAAACCACATCAACCCCCTAATCCAATACAAAAATTAAAACCAACAAAGTGA GCTATAAAAGGAAAACCCCCCCTGAGAGAGAAGAACATGCAAAAAAAGGGGAAAAAACT

GGAATGAAGTGGCTTTC

>'991115a2-048.scf came from CONTIG 35 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-048.scf(77>568) TGTGTCGTCTTGGAGGTGACTCGGCGTGATTGAATTTGCGGCATCTTCGCATTCACTCACA

GGTCAAAATGCAGATCTTCGTGAAAACCCTGACCGGCAAGACCATCACCCTGGAGGTGGA GCCCAGTGACACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAGGAAGGCATTCCCC CTGACCAGCAGAGGCTCATCTTTGCCGGCAAGCAGCTGGAAGATGCCGCACTCTTTCTGAT TACAACATCCAAAAAGAGTCGACCCTGCACCTGGTCCTCCGTCTGAGGGTGGGATGCAGA TTΓTTNGTGAGACCCTGACCGGCAAGACCATCACCCTGGAGTGAGCCCAGNGACACCATC

GAAACGAGAAAGCCAAGATCCANGATAAGAAGCATTCCCCCCGACCACAGAGCTCATCTT GCCGGCAGCAGCTGGAGATGACGCCTCTTTCTGATACACATACAAAAGATCGACCTGCCC TGCTCTCCGCT >'991115a2-049.scf came from CONTIG 36 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-049.scf (77>656)

CAGCTGTGCATCGACATGTTCTCAGTGTCCTGGGTAAGACCAAAGAAGCTGCCAAGATCC TCTCCAATAATCCCAGCAAGGGACTGGCCATGGGGATTGCCAAAGCCTGGGAGCTCTACG GCTCAGCCAATGCTCAGGTGCTACTGATTGCTCAAGAGAAGGAAAGGAACATATTTGACC AGCGTGCCATAGAGAATGAGCTACTGGCCAGGAATATCCATGTAATCCGACGAAGGTTCG

AAGATGTCTCTGAAAAGGGGTCTCTAGACCAAGACCGAAGACTATTTATGGACGGCCAAG AGATTGCTGTGGTTTACTTCCGGGATGGCTACATNGCCAGCCATTACAGCCTACAGAACTG GGAAGCACGCCTGCTCCGGGAGAGTCATGTGCTGTCAAGGCCCCGATTTGCCCCCAACTG GCCGGGACAAAAAGNGCAAGCAGACTGACAGATGGGCGGCTGGAACCTTCTCCCAGCAC CTGAGCTGGGCCCCTCCCGCCACCTTGTGCCTTATACTAACTGGTGAGAAGGACAGCTTCA

CCAGCCTGTGTCCATGTTGGTTAAGCTAAAAGGGGAGGA>'991115a2-051.scf came from CONTIG 37 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-051.scf (83>429) GCACGGGGTCGCCTCTCTGAGTTATCCAGTTCCATCCTTGTCGCTGCGGCGACACCCGCAT TCTCCGTCGCCATGACTGAACAGATGACCCTTCGTGGCACCCTCAAGGGCCACAACGGCT GGGTGACCCAGATCGCTACCACTCCCCAGTTCCCGGACATGATATTGTCCGCCTCTCGAGA

TAAGACCATCATTATGTGGAAGCTGACCAGAGATGAGACCAACTATGGTATCCCACAGCG TGCTCTTCGGNGTCACTCCCACTTTGTTAGTGATGTGGTCATTTCCTCAGATGGCCAATTTG CCCTCTCAAGCTCCTGGGATGGAACCCTTCGCCTTTGGGATCT >'991115a2-052.scf came from CONTIG 38 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-052.scf (77>560)

TGGTGCTGCTGGACGGACTGGGTCCCCCTGGACCCTCTGGTATCTCTGGCCCCCCTGGCCC CCCTGGTCCTGCTGGTAAAGAAGGGCTTCGTGGGCCTCGTGGTGACCAAGGTCCAGTTGG TCGAAGTGGAGAGACAGGTGCCTCTGGCCCTCCTGGCTTTGTTGGTGAGAAGGGTCCCTCT GGAGAGCCTGGTACTGCTGGGCCTCCTGGAACCCCAGGTCCACAAGGCCTTCTTGGTGCTC

CTGGTTTTCTGGGTCTCCCNAGCTCTATAGGTGAGCGTGGTCTACCAAGTGTCGCTGGATC TGTGGGTGAACCTGGCCCCCTCGGCATCCGCAGCCCACCTGGGGCCCGCGGTCCCCCTGGT AAGTTCGGTAATCTGGCGTCATGGTGCTCCTGGTGAAGCGGNCGTGACGCAACCTGGGAT GACGGCCCCCAGCCGCGATGGCAACCCGACACAAGGGAGCGGGNTACCCGCACGCAGTC >'991115a2-058.scf came from CONTIG 40 at offset 0;Ε:\SEQUENCE\export EST_db\991115a2\991115a2-058.scf (68>547)

CGGTGCTGCCTTGAATATTCTGGCACGATGGAGCAAGTTCGGTGAGCGCCGGCGGCGCCC AAATTTTAAGAAACATATCTAGGTCCGCGGTGGCTTGCATGTCTTCTGGTGGGTGCTTAGC

CCGGAGGGCCGGGAATCCAGATATGGGGCCGCCGGGTCTTCAGATACTGAATGAAGAATG CTGAAACTATGTGAAACATGAAACACCGTATCACGATCTTTTTTCATCTTGCTTTTTATATT GTATAACGTTCCGCCGAAAGAAAGGTGGAATGGATATCAGGGTCATAGTCAATATCCTTG TTCCACACACCTTTTACCTCGCTCACCCTTTΓATGTTTTAAATATCCCACCTCGATCAACCA CTAACTCTTCTTAGGTTTCTTCAAAAAATCTATTCCATATCCGTTCAGGGGTCCGTGTACTA

CTTTCAGTATTTCAATTTTAGGTCCAAACTCCTACACAAGGCCCCCATCAATA

>'991115a2-059.scf came from CONTIG 41 at offset

0; "E:\SEQUENCE\export\EST_db\991115a2\991115a2-059.scf (83>633) GCACGAGGATTATAACTAGGCTCAAACATATCTTTATTAATCAAAGGAGGAATCATTATA

ATCAACACATTTTTCCCAACAAGAAATAAGTTTATTTATTCCTATAGCATAAAAACCCATG CTTTGGAATTCAGAGAACTCTTANAAAGCATTTTCTGCCTCCTGCTGGGTGTGGAAGCATT TTCTCTGCAAGAAGTTGTCAGGATGCTTGAAGAAGGGGGAGNTGGTNTGGGCAGAGGNCA GGGGAATATGGNGGATGAGGGCAAACTTTGTAGCCCTATTCATTCAACTTTTGAAGTATTA ATTGTGCATGGGTGGTCAGACGTTGGCATGGAAAAGAAATGGCCCCTTCGTTGACCAATT

CAGCTGTAGGCATTGCAGTTTTGATGCACTCATTGATTTGCTGACATACTCTCCATGTAAG GTTTATCAGATTAAAAAACATAAGAATAGACAGACACAAACACCAAAAGACGNGAGTTTT TTGTCAGNTGGTTTGGAGGGTTGGGTTTTTTCTTACCACGACGCGTTGTGTGTTTTAAACAT TTTGC

>'991115a2-060.scf came from CONTIG 42 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-060.scf (82>480)

GCACGAGGTGATGGTGCAATACTCTTAGCTGCCATAGAACTGAATTGTGGTGCAGCTTGG GAGTGGGCAGTCTATGCATACGACCCAAGGCCTGCAAGCAGTTGGTTTGGGAGCTGACTT GATTCAAGTCGGTGAGAAAGAACACAGGCTTCATCTCTGCCCTCACCTTCTGCTCGCCAAG

AGCAGCCCTCAGCGTTAGAACCGTTACAGAGGTATTAAAACATGCAGATGGCTACCTACG CCCTGTAGTCCTATAAACTGGGTTCTGTTGAGGTCACTCTGTGCCTTAAAGTTAGTCAGTT GGGACCTAATCTAAAAAAAAATAGATAGTTTTTTTTTTAANAGAAAGATTTTGGTGCT^ GTΓACTAGAGACCGATTCTCCATTTTTTGGTGGGGG

>'991115a2-062.scf came from CONTIG 43 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-062.scf (83>591)

GCACGAGGCTGGACAGCTGCATCCCCACGCTGGGCCTTCCCCCCTGPGAATCCAGGTGCT GGGAGCCTTCCCTGGGGTTCCTTGCTCCCCTGGGCAACTTGTAGAATGATGATGGGCCTGT GACACAACCACACATTGCAGGTGCTGTCACCTTTAAATAGTGAGTTCTTTTGATTΓTTAAA

CATTTTCCATAAATCCTGGACTAATTCAGATATCATTTGATTAATTACATAAGAATGACAT CTTTTTGACCTGAATGTGGTAAAAGGAGGTCCATGGGCTACAGGGGGTTAAAAATGGTTT TACAGATATCATTTACTCTTTITGCATTTTATTATGAAAATTTGGATAGAAAAATGAAAGA TAGAGCTCTTGTCCTGGACCACTGCCAGGATTGGTGATTTTGAAGCACCTCCTGCCCCAAC CCCTTGCGCTGGGGAAGAGAAATTAACACAAAGAAGATTTAAATCAGAACCCANAGGAG

AAAGCCGATGGGAAAGAAAAGCGGC

>'991115a2-066.scf came from CONTIG 44 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-066.scf (76>490) CATGGGAGTTGACATCCGCCACAACAAGGACCGAAAGGTTCGACGCAAGGAGCCCAAGA

GCCAGGACATTTACCTGAGGCTGTTGGTCAAGCTGTATAGGTTCCTGGCCAGACGAACCA ACTCCACCTTCAATCAGGTTGTCCTCAAGAGATTGTTCATGAGCCGCACCAACAGGCCACC GCTCTCTTTTCCCGGATGATCCGGAAGATGAAGCTTCCTGGCCGGGAGGGCAAAACAGCT GTGGTCGTGGGGACTATAACCGATGATGTTCGTGTCCAGGGAGTGCCCCAACTGAAGTGT GTGCTTTGCGAGTGAGCAGCCGCGCCCGGAGTCGCATCCTCAGGCCGGGGCCAGATCCTC

ACCTTCGACCAGCTGGCCCTGACTCCCCCAGGCTGGGCACTGTCTCTCTCTGTCC

>'991115a2-068.scf came from CONTIG 45 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-068.scf (83>551) GCACGAGGGTTTTTTTTTTTTTTTTT^

ACAAATGCTGTAGTTATTAAAAAGGACTCAAATTTTACAAGGAATTAATTTTTATAAACAA GTTCTACAATGAAAGGGAAACAGCATCTTGATACATAAAAGTGTTGTTAAACAAGATTTA AAAATTTTTAAATCAGAAAATGTTTTAGACTAAATTCTTTCAAACAAAAACAAAAAGCAA CCTGTACAATCTCCATAATAAAATGGGTCCCTGTACACTTGGCCTGGATACAATGTTAAAA

TTTTCAAAGTTTGAGTCAGAGAGGCAGGACTTTAAAAAGACATTTTTAGTAAAACATT^ CCATITATCCAACTATGCATTTATTTTrTGTTTTTCAGAAAAGGGGATTATAπ TTTTTACTGTAAAAAAAACTTTAGGAAATTTACTTCCCGAG >'991115a2-095.scf came from CONTIG 45 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-095.scf (83>123) GCACGAGGGTTTTTTTTTTTTITTTTTT^^

>'991115a2-070.scf came from CONTIG 46 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-070.scf (84>573)

GCACGAGGGGAGGCCCAGGCCTGCTGGACTTGGGAGTTTCCAGTGTTTCCCCTAGCGCCT GCGTTGGGGGCGGGCTTAAAGACATTGTAATTAGTTGTCGACATGTTGCGCTTGGTGAGCT GGAACATCAATGGGATACGGAGCCCCTTGCAAGGGGTGAGATGCGAGGAGCCCAGCAGC TGCAGCGCCATGGCTATGGGGCGCATTTTGGACAAGCTGGATGCAGACATCGTCTGTCTTC AGGAGACCAAAGTGACCAGGGATGTGCTGACAGAGCCCCTGGCTATCATTGAGGGCTACA

ACTCCTATTTCAGCTTCAGCCGTAACCGCAGTGGCTATTCTGGTGTAGCCACTTTTTGTAA GGACAGTGCTACCCCAGTGGCTGCTGAAGAAGCCTGAGTGGCCTGCTTTCCATCATATGG GGAGGGGGTGTTATGGAAAATGAAGACTTACCAAGAGAACTTGAGCTTGATAGGAGGGC GGCCCTCTA

>'991115a2-071.scf came from CONTIG 47 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-071.scf (77>427)

CGGGCTACAGGCTCGAGGATGGCGAGTGTACAGATGTGGACGAGTGTGAGCTGGGCACG CACAACTGCCAGCGGGCGCCGTGTGCCACAACACCAAGGGCTCCTTTTACTGCCAGGCTC GGCAGCGCTGCCTGGAAGGCTTCCTGCAGGACCCCGAGGGCAACTGCGTGGACATCAATG

AGTGCACATCTCTCTCCGAGCCGTGTCGGCCCGGCTTCAGCTGCATCAACACGGTGGGCTC CTACACGTGCCAGCGGAATCCGGGGATCTGTGGGCGCGGCTACCACGCCAGCCAGGACGG GACCAAGTGTGTGGACGTGAACGAGTGGAGACGGGTGTGCACCGCTGNCGC >'991115a2-072.scf came from CONTIG 48 at offset

0; "E:\SEQUENCE\export\EST_db\991115a2\991115a2-072.scf (84>559)

GCACGAGGGAGTGTCTTTATCGCTGTGGAATCTCCATGCAGGTTCTCGGGGTGCCGGGCG AGTCTATTTCCGGGCCCGCGCTCGGCCCCGGCCCGGCGACCTGTTCCAGCCTCTGCCCGGG GTCTGCGGGGCGGGAACGCCATGCCGTGGGCTCTATTCCGAGGCCGAATCTGGTAGCCCA AAGATCAAGAAACCTACTTTTATGGATGAGGAAGTCCCAAGCATACTCATCAAGATGACA

GGCTTGGATTTACTGAAGATTTTTTAGCCAGCAGTACAAGAAACGAAACCACCAACTACA AGCTATGACCCAGCACAGTGGAAAGAAGCTACAGACAGCGATTGAGCAGCTAAGTNAGA TTAAAAATGCACCAAGTTGGAAGACGACACCATAATGATGTGTAGTGAGATAGATTTGGA GGACCGAACAGCAAATGTGTTATGATATATGACGATACAATGGAGGTTTATGTGGA

>'991115a2-074.scf came from CONTIG 49 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-074.scf (83>452)

GCACGAGGGCCATCTTTGCATTGTTCCCGTCTCCGGCTTCCCTGATCGCCGCAGCCACCTC CGCCGCGCGCCATCTCCGCCGCCGCGGGCTCCGGCAGCTTTACCGCCAGAGTCCTCGAACT CCCGCTTTTCTTCTCAGTCCTTTGCATCGGATCACCGGAGTGCCCCATCATGTCAGACGCG

GCCGTGGACACCAGCTCCGAGATCACCACCAAGGACTTAAAGGAGAAGAAGGAAAGTGT GGAGGAGGCGGAGAATGGGAGAGAGGCACCTGCAAATGGGAATGCTAATGAGGAAAATG GGGAGCAGGAGGCAGACAATGAGGTAGACGAAGAAAAAGAGAAGTGGTGAGTAGAGAG AGAGGATAAAG

>'991115a2-075.scf came from CONTIG 50 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-075.scf (77>568)

GGACGTTCGGCTTGTGAGCGGGAACTTCTCGGTCGCGCACAGAGAAAGAACGATTTAAAA ATGGGTGATGTTGAGAAGGGCAAGAAGATTTTTGTTCAGAAGTGTGCCCAGTGCCATACT GTGGAAAAGGGAGGCAAGCACAAGACTGGGCCAAACCTCCATGGTCTGTTTGGACGAAA GACAGGTCAGGCTCCTGGATTCTCTTACACAGATGCCAATAAGAACAAAGGTATCACCTG GGGAGAGGAGACGCTGATGGAGTACTTGGAGAATCCCAAGAAGTACATCCCTGGGACAA AGATGATCTTTGCTGGCTTTAGAGAAAGGAGAGAGGAAGACTGATAGCTTTCTCAAAAAA TACCAAGAGTATAGGTGGCCCTGCCTATTTTTTATGATANAANGTCTATGATTTTATGTGT

ACATATTTATTGACTATATATATATCANATATGACGCTGAGGATATTTTTTGACGCCTGTTT AATAAATGTTG

>'991115a2-076.scf came from CONTIG 51 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-076.scf(84>556)

GCACGAGGAAGAATCTCTCTTTAGTTGTTTGTACGGAGGTGAAAAAAACAAAAAGATCCT TCAAAAATGGCAATGGTATCTGTATTCCTCAAGCAGGCCTGGTTTATTGAAAATGAAGAG CAGGAATTCATTAAAAGGGGTAAGGATCCAAAGGGGGTCCCTGGGTCAGCAGTGAGCCCC TATCCACGTTCAATCCATCCTCGGGTGTTGAGGCCTTGCACAAAGCAATCACCGTTAAGGG GGGGGGAGAAGCAACCATCTTTGAAATTCTGACTTAAAAAAACAATGCCCAACGTCAGCA

GAACAAAGCGGCCTATCTGCAGAAGAAAGAAAGCCCCCGGAGGAATTTTGAAAAAGACC CCCTCGGCACCTTGGGGAGTTGTTGGGGTTTTTGAAAACCCGCCCAGTTGTTGCCAAAACC CCGGCCGCCTGAGGGCCTGGGACGAGAAAACCTCTGATGAAATTGGGCTCCA >'991115a2-077.scf came from CONTIG 52 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-077.scf (78>624)

GCCGATTTAACTTTACAGTAACAGAATAGACAGCACAACACAGACTCTCTCAATACAGAT AAACTCACACATACTGGAGATTATATATAATAGATATATATAAAAATTATTTTAATGCATT GTAGTGTAATATTTATGCCTACTATACTGTATAACACGTTATTCAAAAGGGATATGCCATT TCTGAGACACGATAACAAAAAAAAAGTTTGAGGAAATTATTTTGCTTCTATTTATAGCTCT

GTCAAAAGTCAGAAGACTCTAAATGCTTTGCAAAAAGGGGTTCACATTTGCTTAAATGCTT CATCACAGTCACATTTAATATAGTGACTCTAAACAAAGAAGAAGCAGCACTGTCATCAGA GGCATGATAAACCAAATATGANATGGGAATGTTTAATTACCTAGTATTGGTGGGGTAGTA CTGGTGGATTTATTGTGATTGTTTTNTTTGTTTTTCAATTA AATTAAAAAAAAGAGTGCTTCGTTTTTAGATGAATCTCCAAGGATCCTTTTGTGTTGGTG

>'991115a2-078.scf came from CONTIG 53 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-078.scf (78>494)

CTGGTGTTGGAGCCGAAAAAGCTGGTGGTTTTGCCCCATATTATGGAGATGAACCGATAG ATTTCAAAATCAACACCGATGAGATTATGACCTCACTCAAATCAGTCAATGGACAAATAG

AAAGCCTCATTAGTCCTGATGGTTCCCGTAAAAACCCTGCACGGAACTGCAGGGACCTGA AATTCTGCCATCCTGAACTCCAGAGTGGAGATTATTGGGTTGATCCTAACCAAGGTTGCAA ATTGGATGCTATTAAAGTCTACTGTAACATGGAAACTGGGGAAACGTGCCTAAGTGCCAG TCCTTTGACTATCCCACAAAAAACTGNGGGACAGATTTTGGTGCTGAGAAGAAAAGTTTG GTITGGAGAATCCTGGGGGGTGGGTTTAGTTTAGTTTGGCATCCTGAACTTCCGAA

>'991115a2-079.scf came from CONTIG 54 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-079.scf (84>272)

GCACGAGGCGAGTTTTTTTTTTTTTTTT^^ TTΓAGGGTTAGGAGTAGTAGGGGTAGGATGTGTAATGATATGAGTGCCTTTTCCCGTGTAA

AGGATGGCGAGATACTATTAATGTGGTAGGGATATTTTTCTTGTTGGGTTTTAATTACCAT

GCCTA

>'991115a2-080.scf came from CONTIG 55 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-080.scf (77>649)

CTCACCATCAACCCCCAAAGCTGAAGTTCTATTTAAACTATTCCCTGAACACTATTAATAT AGTTCCATAAATACAAAGAGCCTTATCAGTATTAAATTTATCAAAAATCCCAATAACTCAA CACAGAATTTGCACCCTAACCAAATATTACAAACACCACTAGCTAACATAACACGCCCAT ACACAGACCACAGAATGAATTACCTACGCAAGGGGTAATGTACATAACATTAATGTAATA AAGACATAATATGTATATAGTACATTAAATTATATGCCCCATGCATATAAGCAAGTACAT

GACCTCTATAGCAGTACATAATACATATAATTATTGACTGTACATAGTACATTATGTCAAA TTCATTCTTGATAGTATATCTATTATATATTCCTTACATTAGATCACGAGCTTATTACATGC CGCGNGAAACCCAGCACCGCTAGCAGGGATCCCTCTCTCGCTCGGGCCCATAACGGGGGG GCGCTTCTATGATTTACAGCATTGGTCTTCTTAGCCCTCTCTGTAAAGGCCTTTTTCTCTAA TAGAAATTGAGACTAGGTAATAGCTT

>'991115a2-082.scf came from CONTIG 56 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-082.scf (82>671)

GCACGAGGGATGAGTGCTAAGGGTTGATGCTGGTNGCCCCTGGGAGCCCCCGGTAAGCCA GGGCTGTCCCCTTGGCGCTTCATAGGAATGTCGCTGGTGATTACGAGGTGCAGCGTGTGTC TTCCAGGACCCTAAAGGGTGACAGAGGGGGATGCCTGGTCCCCAAAGGGTGCTGGATGGG TGGCTCNNCTGGCAAAGATTGGCGTCCGTGGTTCTGGACTGGGTCCCCATTCGGTCCCTCC TGGCGCCCCCGCTGGTGCCCCCTGGTGGACAAGGGTGGAAGACTGGTTCCTTAACGGGCC

CCAACCGGTCCCCACTGGTAGGCTCGTGGTGGCCCCCGGTTGACCCGTGGTTGAGCCCTGG TCCCCCCCGGCCCCTGGTGGCTTTCGCTTGGCCCCCCCTGGTGCTTGATGGCCAACCCTGG TGCTTAAAGGCGAACCTGGTGATGCTGGTGCTAAAAGAGACGCTTGTCCCCCCCGGCCCT GCTGGGCCCGCTTGACCCCCCGCCCCCATTGTTAAGTTGGTGCTTCCGGACCAAAGGGCTT GTGGCAGCGCTGTCCCCCTGTGCTTATGTTTTCCAGGGCTGTTGA

>'991115a2-086.scf came from CONTIG 57 at offset

0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-086.scf (76>860)

TATCGTACGGACAGAGGGTTTATATCACCTTATTCCATATCCCCTCTTTGGGCTGTGGTTG ATGCAGTATCATGGATGGGGGATGGACGCCCCCAAGGTTCATTTGCCCGGTGCATCTTACC

TTGGGACAGACTCCGGAACCAGTTGGGGAGGAAGTGTCGGTCTTTGGAGAAAGCGGAGA GGATGTTGACGTGGTTGCCTCTATATAAAAATGGGGTTATCAACCCAGGTGGGTGGGCCC TTTCAATAATATAAAAAGCTCAATGTGCTACGGCCGGCATTTTTCCATTACTCCTGTCCCC CCCCAGTCACTCTTGGGCTTGTCTTAGACCTTATGATGTTGTCCATTTGTTTTTCTTGTTGCT TGGGAGGCCCCAATACTTTTTTTGTCCATTAAATATTCCTAAGGGATCCTCTTGTGGAGGT

ACGGCTCAAATTGGGTTGGTTGCTCGTGTATAAGCAACAAAGGGCTGAAGGGCCAATTTT TCTTTGGAGGGTTGGGGGCTGGTGTTTAACACCAAAGAAATTGATTGGGGGGCTTTCTGGT AACCCCAACGAGAATAAAAATGGGGTCCCCTTTCGCACCTTTGTTTTCTTTGGCCCGGCCC AAGACTAAAAACAATTTGGCGAGCCACAGGTCACCACCCGGGCCCGCACCTTCGTTTAGG GGGGGAACACTCCTCCTATACTCCCTCATATATTGGTAACACATTTTCTGGGCTCTTGTTGT

CTTCGTCTTGCTTTGTGGGTTTGCGGGGGGGGCCCCCCTCCACTTTCTTGTCTCA

>'991115a2-087.scf came from CONTIG 58 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-087.scf (83>749) GCACGAGGCTACANTCGGGCCTTGCAAATACCATCCCCCCCTNGCCTGGACTCCGCAGCT

GACTGTATATTCCCCTTGCNGCCATGCGGGGACTGGGCTTATAGATACGTCCTGGGTCAAC GCTGTTACGAGGAGGGGACGGAGGGACAAACAACCTCCCTGGACCGAAGAAAGCAGAAA GCCTGCGAAGTGAAAAAAGATCCCACGAGAATGAAGAAGACGCGCTGGAGGCTGGCGGA CCATTCCTGTGGAAACTGCCTGGCCCCGGGACTTCGAGAAGAAACTACAACATGTTACAT CTTCCCTGTGCACTGGCAGGTCGGGGCAGCTGGATCAGCACCCCATTGACGGGTACCTGTC

TCACACCGAGCTGGCCCCACTGCGCGCCCCCCTTATCCCCATGAAACACTGCACCCACCCG TTTTTGAGAATGTGACCGGACACGACAGACATCGCCTGGACGAGGGGCCGGCTGCTGGCA TCAAGAAAAGACATGACAGGACCCGGATCAAAACAGCCTCCTCGAAAACAATTTTTTTTT GACTCCCTCTGTTCCCAAGTTAAAGTGGAGGTTGTGGTTGCTGGGAAGGGTAAATAAAAA AAAAATTAAGGGTAAAAAAAATTAACAAACAAATTAATAATTAATTAGGTTTTGTCCATA

AGGCCG

>'991115a2-091.scf came from CONTIG 59 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-091.scf (78>508) CGCCGGCGTGCCCACGTCCAAAGGAAAGTCCAGGAGGAAAAAGGATTTACGAATCTCCTG

CATGTCCAAGCCGCCGGCGCCCAGCCCCACGCTCCCCCGGAACCTGGACTCCCGGGCATT CATCACCATTGGAGACAGGAACTTTGAGGTGGAGGCGGATGACCTGGTGACCATTTCAGA GCTGGGCCGAGGTGCCTATGGGGTGGTGGAGAAGGTGCGGCATGCCCAGAGTGGCACCAT CATGGCCGTGAAGCGCATCCGGGCCACCGTGAACTCTCAGAGCAGAAGCGCCTGCTCATG GACCTAGATGTCAACATGCGCACGGTGGACTGTTTCTACACCGTCACCTTCTATGGGGCCC

TCTTTAAAGGGAGACGGGGGGATTTGGATGGAGCTTATGAACCGTCCTGGACAGTTCTAT GGAGGTGCTT >'991115a2-092.scf came from CONTIG 60 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-092.scf (84>529)

GCACGAGGGCACTTTATGATACTTTTTCTGCTTTTGGGAACATTCTGTCCTGCAGGTGGTG TGTGATGAGAACGGCTCTAAGGGTTATGCCTTTGTCCACTTCGAGACCCAGGAGGCTGCC GACAAGGCCATCGAGAAGATGAACGGCATGCTCCTCAATGACCGCAAAGTGTTTGTGGGC

AGATTCAAGTCTCGAAAAGAGCGGGAAGCCGAACTTGGAGCCAAAGCCAAGGAATTCAC CCATGTTTACATCAAAAACTTTGGGGAAGAGGTTGATGATGAGAATCTGAAAGAGCTATT TAGCCCAGTTGGTAAGACCCTAGTGTTAAGGTGAAGAGAGATCCCATGGGGAAACCAAGG CTTTGGTTTGTGAGTTACAAAAACACGAGATGCCAAAAGGCTGGGGAAGAATAAAGGAA AAAAATACTGGAAGGCATTTCGTGCCG

>'991115a2-094.scf came from CONTIG 61 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-094.scf (72>264)

CTGCAGGCCTGTATGCTTGGGAGGGCATTGGGGGGGCCAGGAGNNGAGGAAGGGGGACG CACAGAAGGGATGGAGGATGGGTTGGGATGGGCATCCACCTGCACCTTCGCATGGNAACG

TGGAGTTCCTGGAGTTGCAACCTCCTGGGGGAGTTTGGGTGGATAAGCACAAGGGGAAGG CCCTGGGCGGTGCC

>'991115a2-096.scf came from CONTIG 62 at offset 0;"E:\SEQUENCE\export\EST_db\991115a2\991115a2-096.scf(78>582)

CGGCAGTAGCAGCCATGAAGGTCGAGCTGTGCAGTTTCAGCGGGTACAAGATCTACCCAG GACATGGGAGGCGCTACGCCCGGACCGACGGGAAGGTTTTCCAGTTTCTTAACGCAAAAT GTGAGTCGGCATTCCTTTCCAAGAGGAATCCTCGTCAGATCAACTGGACTGTCCTCTACAG AAGAAAACACAAAAAGGGACAGTCGGAAGAAAATCAAAAAGAAAGAACTCGCCGGGCA GTCAAATTCCAAAAGGGCATAACTGGTGCTTCTTTGCTGATATATGGCCAGAAGAATCAA

AACCTGAAGTAGGAAGCTCAACGAGACCAGCTTTAGGGCTGCCAAGGAGCAAAAAGGTT AGCAGCATTAAAAGACGCATGCTGTGGAAGCTCCACAAAGCAGCACTAACAAAAATGGA ACCGGGAGGTTTTGTCTGGGTGTGAAAAGCTAGTGCGATGATTTTGAAAGAATGATTTAA TAAAAAAAAAAAACGAGGGGGCCGGCCC

Table 3

GNCCCTTATAAAGTGNNNNTCCNAATANNNGGGGGTATTACTATTTACAANTNTTCNTCN CTATAACNGAAGNCGC^AT(^CAAN(^GGCCCTTNANCNAATANCTNNTCTTCCNTANCA

NNCTANATTT<^TGANCCTTAATNCCGTACAANNACTNAATACNCTCTTGNTACATCCCAC NNTNNTATNNNANTNTNNTCATTACCTCATNTTNCTCTAANNNGGTTNTTTGA^ TAATTCαSfNNTANGAGGNAGNCTGAANTTTNNTNANANNTTAGACATCCGNTNTATANAG AANTNNANNNTANNCCTNNATGANGNNATNNNACTCNGTTTNNGTNNATTTA^ MSπSTATNCTTGNNNGCCANGATCCATAT^^

GGNNGCNNGTNGAANACNCNGCNAGANATAAGGGGGACANNTNNCTGAGTNNTCAATNA CANGATNCGATANAACTTACTNCTNATAGTNGNNAGTTANNNGCAGTNATANCNTTACAA NNAANNNNGGNNTNTWGNNTNNCTTATTANGAGGGGNAGNAΛTNNNNNAGNCT^ NTNAOSπSfCNNNTNACNTNNATATNANGCTNANNAANNNACNCNNGNANGGNCNNANAN NGAGTTTTANTTAGTNCANAGGTGNNNΓ^NNTAAANGNNTATNATGNGGATNNGNCGAGN

NATNGNANTNTACGNNNNNTTAGATNNGGGGNAAGGATNGNNNANTTGATTCTNAANGG NGGNNGAGGCANGNGTNANTSπSlGTαsπsrGNNNCTTCTNNCNNNNGANGNGGACAGAAT^ NGNNGTGATAGGGNTTαWGNTNGNTNNAGNNNNGAANANCNNGNGNGGNNANNANAG TANNTNGNGANGNNTTCGNCNNANNGNGNAANTCNTAANTNGNNGNANNNANNNNCTNT NNTNNGTANGNGNNGAGCANAGANATCAGANGNANGCATNTACNNNCNAGGNGGNNTG

AGANGNANATANANGTTNACNAGNTNNNACNCACCNGAGNNTTTNGTANNCATTNACNN NGAANNTANNTNATNNANTGTNANTGANNCNTAGNGACMGTTAGANTANGANTAGTGTN TANGTNANAOSπSIAGNCNNGAGAGTGNANAGAGAGATATNNNATGNACNNGTAGAAATNT NTNNTCNCGNGATATGTATACGANCTGCGCGAGACG

TTCANCGGCNTTNNNNNGNANNCNTNNNTNTSINGGGGGTATTANTANTNCAAANCNACGC

GCCTATAGNGAGTCTNTANTGCANANGTGTTNTNGGANNGAGTTNTNNATTNCTNGCANN

NTNCTCTNNNNCTTATTGNNAGNGTCNNTTCNNNATAACTNTTCNTNACCTGACGGGCTA NTNANAGAATNGNAANTCGNNNTNGTGNTNNTATNAGNGCACANANAGGNNNTGNGANA

CGGTNOSINGGCCNACNGGAAGACTGNTCCATTGTNNGTNCTAGCGGGANGNNNTNNTAG TNTTTTTNTGNCNNNAGNNTNANAGNGGGNGACNNCNNGNGGNTCAGCTGGCTGATACTC GCGNANTCNTGCNNNCNCNGATNGANNGTNNNNAATNTCNCAANATAANGTCGANNTNT CNATAANGAGCGNCGNNCNNTAANCTGGNGCATCTNCNGTGNGNCNAAATTCGGTANGT NNTATNTCTANNrWACGNNGTNNNGNCCNTANANTTCNATACATNANNTGANNNNGNCN

GAGGGANCNCGTTTNANGAACTANAAAGNGACGNGTGGATTANNGCCNCCNGTGTACTT GCNGAGTNGT WαWANNCNNANGANNNGAGNNCCNTTGNNNNANATCMINTAT^ r>[NNNTTCNNACTGNCGATNNTN^ TNCNNNAGGANNATGNTNAGNNCNGATGGTNNCNTGGGTGNANTCCGAGNANGATNTCN AANNGGCTTNGAGNGNNANATCGAACNTANTGACNNGACNAGANCCNGNNCNTANNCCT

CNC WAACANNTGAArø^NNNGNGATGGNCGαWAGANNNTNNCAANTACNANNAGCTA CGANNNCNGGTGTNNAOSINT>JNNGTIS^^ TGACNNNTGANCTNNNCNNNAG(^TANCGANTC ATNCNATGNCGNGTGCATCATGNANGAGNNNGTCATNNNTNNTNNCACTATGTCTACGAC TTGANANC(-^ANNTCAGNNCANTNCGTATNTCQ INNGANGTCNCNNCGT NGNTCTCGAT

GAAGNTCNNGACGNAACTNNATGTNCCNNATTNCNGTATGACNNCATNGACNTTATCGTG NNANNNGCTNACNNTANATGACGNNCTTCTNTGNANTNCCGTGCNNGCGCNTCCTGNNNA CCGACGTCCTANNNACGN ^CANGTATNGCATCAGGAGNACANGTTNCNNGTNNNTACN CGTGGTAAGNNNNGTNTCNTNNCTTCNNNNTTCNCN

GCCCTATANGGAGNNGTATNNCAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGCNGAGGTCTCCGGCCCTGTNTGCGCANNANGAGGCTGGGANATGGGCCCCAGGT

CCCCCTGAGCCAACCTNCCGAGGANGANCTTANANAGGTNNNACCAAGANGCTGGNGCA <_^ANATGAACCATOS[NNCCANTNTANNAJSrTNCTTCANCCGCTGCGATNNNTANNNAAAAC

NNTANNTNNANNGNTTNTNNTATATTTTANCCCNTANAANNATNNNTATNTNT^ TAAAAC^TNGNNTTNNNTAATNNTTNTTTGANANNNTTNTTCTCCCCT^ GTTNTAAATNANA(^TATNNNAGNGAGNNNNAACATNAATNNNNTGCNGNN NTNNNNTNAACTTATTGCATAAATNGNNTTNATATATNANATNTATNCANNAAACANACN NNATTACMNNTATTTTATTNTN^ GATNITTCAAATTAATTATNNΗS^^

TGTTGNGANTNNNNNANAN(^CTGTGTACCCCTAACTNNNOSlNACACCCNNCCNNCTNNC CTANTCTTCNNTTTCTATNACCGAATANNACπ^^ C^ANANANTTANNATCTTNAANTNCNCCAAN^

TATAANNTCGAACNr>lNNNCCTAAGTNAATTTO^

AGAAANANANATNATNNTNNTNANTATANANNNTNANNAGACTAATATANATNAANCTA CCAT ΪNNNNNAAANANANANANNNTTCNNANCTT(^ACAAANATATNTG INAT NNATC TANCTTATGTNCNNTAAGAANNNNNGNTACNATTNAAGNNTAAATNTCANANGNATCNA ACCNTNTCNATCGCCATAANAANNCNNATANNTATACANTAATCTCANTNANTNCGTANA

NTNNNNNATATNNANNCNTNNGCNC

GNGCCTNGTGGGNNTTNTNNANNTATATTNANTTG^ NNTCTTNNNGNNNCNTTCCCNTNTN^^

TGAGCOSINNNNGATCGTATTACAGTGGCGGCCGCTCTANAACTAGTGGATCCCCCGGNCT GCAGGCCGCTTCGNGATCTGNGGNCCCCGGTGCAAACATGGCCAAGTCCAAGAACGNAC NCCACGCACANNCAGTCCCGAAAATGGCNTANAAACGGCATCAATANACCCCGATCACA ATGATATGAATCTNTTAAGGGGGTANACTCCANGTTCCTGAGGAACATGCGCTTTGCCAA GAAGCACAACATAGAAGGNGCCTNNAANANGATGCNCGCNNNCCAATGNCAAGGCCATG

AGTTGCACCGTGCTGANGCTGTCAANGCCCTCCTCAAACCCAAGGANATCANNCCCAAGA TGCCAACAGGTGGNAANTCGTAAGCTCAACCNACTTGCCTACATTCCTTACCCCAAGCNG GNNAANCGCGCTCGTTGCTTCGNATCTGCCAAAGGGGCCTTNATGGCTCNTGNCCGGGTC CAAAAAGATNCGTAGGGTCAANGGTCTΓTNNAACCCATTGGNCCAANGCCACCTTGGCNN NCTTGCCTNNTTNACAAACTTGGCCAAAGGGGTTGGTCNNNTGCGCCNCCAANCCAAAAA

GGTTTNCCCGGNGANGNTAANAGNAACACTTTTATTTNTGCCCAANGTTGTGNGATNGAC CAGNAAANNGNAACNTTGGGNNGTAGGAACCCCCCCTTGGNGCCCTNGCNTTGNNCNCTG GCGATNGGGNGNNOSITGANTGNTNACCNCNCTTGGTGGCCTANTTATTGNCGNCCAAAAA TTNANATATCTCGCGGCACCTGGGGTNCNTNNTNNNGNNTTCTNTTACAAGTANNTNCCC CTTTΓGCGNNAGGTGGGGGGGGTGNCNCGCGTATANACCCTTNTNTTCTCGTCCCTTCTTT

ATATTGTGANGNCTGGNTNATANTTCTCAATACNTGNACNTCTNCTNTCTTGGNCTTGCNT NGGANTTCNTNNNACANTAANTCTNCNΠSΓANNTAGTATTTTNCNAANAGAGTTACTCGATA CTTACACC⁽-NTNGAAAGNTNNCNNGATTTANTGCNTTCTTNNTCTTTTT^ ACGTGNNGNTANCTTNTNNTOTO^ NTNGTTNTTACGNTATNNTCTCATNACGTNACNTCTCTCNGNTATGCTNTNGCTNNATCTT

ATGNTCTCTTCTCTC^TCCTNTNNNTNATGTNATTGTATATNTCCGATATCCNTACNNTGGC

TCGCC

GNGCCTNGTGGGNNTTNTNNANNTATATTNANTTGNNNNISπSINTNN

NNTCTTNNNGNNNCNTTCCCNTNTNTTCTTNNNNGGNNGNNTTTNGNAGNNTT^ TGAGCCNNNNNGATCGTATTACAGTGGCGGCCGCTCTANAACTAGTGGATCCCCCGGNCT GCAGGCCGCTTCGNGATCTGNGGNCCCCGGTGCAAACATGGCCAAGTCCAAGAACGNAC NCCACGCACANNCAGTCCCGAAAATGGCNTANAAACGGCATCAATANACCCCGATCACA ATGATATGAATCTNTTAAGGGGGTANACTCCANGTTCCTGAGGAACATGCGCTTTGCCAA

GAAGCACAACATAGAAGGNGCCTNNAANANGATGCNCGCNNNCCAATGNCAAGGCCATG AGTTGCACCGTGCTGANGCTGTCAANGCCCTCCTCAAACCCAAGGANATCANNCCCAAGA TGCCAACAGGTGGNAANTCGTAAGCTCAACCNACTTGCCTACATTCCTTACCCCAAGCNG GNNAANCGCGCTCGTTGCTTCGNATCTGCCAAAGGGGCCTTNATGGCTCNTGNCCGGGTC CAAAAAGATNCGTAGGGTCAANGGTCTTTNNAACCCATTGGNCCAANGCCACCTTGGCNN

NCTTGCCTNNTTNACAAACTTGGCCAAAGGGGTTGGTCNNNTGCGCCNCCAANCCAAAAA GGTTTNCCCGGNGANGNTAANAGNAACACTTTTATTTNTGCCCAANGTTGTGNGATNGAC CAGNAAANNGNAACNTTGGGNNGTAGGAACCCCCCCTTGGNGCCCTNGCNTTGNNCNCTG GCGATNGGGNGNNCNTGANTGNTNACCNCNCTTGGTGGCCTANTTATTGNCGNCCAAAAA TIΗANATATCTCGCGGCACCTGGGGTNCNTNNT JNNGNNTTCTNTTACAAGTANNTNCCC

CTTTTGCGNNAGGTGGGGGGGGTGNCNCGCGTATANACCCTTNTNTTCTCGTCCCTTCTTT ATATTGTGANGNCTGGNTNATANTTCTCAATA(^TGNAC3SfTCTNCTNTCTTGGNCTTGCNT NGGANTTCNTNNNACANTAANTCTNOS1NANNTAGTATTTTNCNAANAGAGTTACTCGATA CTTACACCCNTNGAAAGNTNNCIWGATTTANTGC^^ ACGTGNNGNTANCTIΗTNNTCNGTTGT(^^

NTNGTTNTTACGNTATNNTCTCATNACGTNAC^TCTCTCNGNTATGCTNTNGCTNNATCTT

ATGNTCTCTTCTCTOSΓΓCCTNTNNNTNATGTNATTGTATATNTCCGATATCCN^

TCGCC

TNNNNNAAAAGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGCAGGATCAAGCGATTCCTGGCCAAGAAACAAAAGCAGAATCGTCCCATTC

CTCAATGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATT GGAGAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGTCTTAAC

ATGTANACCACTTTTTTAAGCAGCCAGATCACAATGAAAACATCACTACTGTAANGCTNG

GCCCATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCATTAAATATAAANCGTTGCA

AAAAAAAAAAAAAAAANNNGGGGGGGGGCCCGGGCCCCAATTNCCCNTTNNGGGGGGN

NNTTTTAANANNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNMNNNNNNNNNNNNTSINNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNrINNNNNNNNNNNNNNNNNNNNNNN^

N NNNNNNNNNNNNNNNNNNNT^^

NNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNN^

TTGANANNATTGGACTCCCCGCGGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGATTCGGCACGAGGCCGNNCTTGCCTGCTGCCTGCCTGCCTGCCACTGAGGGTTCCC AGCACCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCC CTCAACAGGAAGCCTTGCCTGATGAGACAGAAGTGGTGGAAGAAACCGTGGCCGAGGTG GCCGAGGTACCCGTGGGAGCCAACCCCGTCCAGGTGGAAGTAGGAGAATTCGATGATGGT

GCCGAGGAAACCGAGGAGGAGGTGGTGGCCGAAAACCCNTGCCAGAACCACCACTGCAA ACACGGCAAGGTGTGTGAACTGGACNANAACAACACCCCCATGTGTGTGTGCCAGGACCC CACCAGCTGCCCTGCCCCCATCGGCAAAGTTTGANAAGGTGTGCAGCAACAACAACAANA CCTTCAACTNTTCCTGCCANTTTTTNGCCACCAAGTGTACACTGGAGGGCACCAANAAGG GCCACAAACTCCACCTGGACTACATCGGGCCTNGCAAATACATCCCCCCTTTGCTTGGACT

CCGAGCTGACTGAATTCCCCTTGCCCATGCGGGNACTGGNTTAAAAAACNTCNTTGTCCCC NNTTTNCANAAAGGGGAAAAGNAAAAANAACTNTTCTNNCCCGAAAANCCAAAACTTTG CGAAGTGNAAAAAATATCCCCCCGAAAANTTGAAAAAGCCCCCTNGGGGGGCTGGGCAA ACTTTTTNTGGGGNAAATTTGGTGGCCCCGGGGATTTTt^CACOSINCCNCCCCNCAAANGT GGACCCTTTTTCCCTTGGG(^CCTGGGNAANTTTGGGGGCAANTTTNGAAANCAANCCCC

CCCNTTTGGNNGGGGTCCCTTTTTTTNAAAACCNGANGGTTGGGGNNAAANNNGNNCCCC CCCCCCTTTTTTTCCTTATNGGNAAT

TTNNNAAAGCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGGGAATTTGGTCTCGCGCGGGTCAAAAGCNNCGNGACCAAGACTATGAANGGTT TTGAATACATCTTGGCCAAGCTGNAAGGTGAGGCCCNTNCCAAAACCCTTGTTGAAACAG CCAAGGAAGCCAAGGANAAGGNCAAGGAGACGGNNCTGNCAGNTACAGAGAAGGCCAN GGACCTTGNCAGCAATGGCAGCCACCAAGAAGCAGCAGCAGNANCANNAGTTCGTGTAT CCAGCCCANGCCCTGAAGCATCANNCTAGCAGACTACCAGCTCCAGGCCNTGNGCCCCCT

NCTCTTGTACTTTATTATTAAAAGCCAGCTTNTATCCCTNTCGACTGTCTGGGTGNTGGGCT GAGGGTANGNGCCCTGTTTGGCATTTTCAGCATAGCCAGCTGGTTACCCATATTTGANCCG GGCTTACTTACCCCTGCATNGGGTGNCTGAGGACACATGCNCATNGACTTGCCCACGGNC ACCGTATNCANGTNANGCGGTCNTGAATGCTATACTGTNNGCTACATGANGNCANGGANC GTCGNTN πSfTCCTCTGXTGAGAACGAANTATTTGAAACAAAAATNTTGNGTTGTNACANG

CNCNCAAANNATACTTTGACGGAATT(^ATNNGACCCTTTNTAACAATTAAANCCTTNNN AACANAAC(^CTNGGGGGGGGGGCCGGGGGCCCAACCCCCCCCC^TTATTTTGGGGGNCC CCC(^TNAANCANNAAAGNCCC(-^TGGTTAAAAAACCCTTTTGNCCTTATrGGGNTTTCCG GGGNTTTNTTNTTACCCTGGGNCCCCATTNTTTANTTTNAAAAANAANGGGGGACCCAAA NCCCTTNTTTTTNCCANGNCCCCTTTTTTNTTTCCCCCT^^ NAACCTTTTTTAAAAGCCT

NAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGGGAATNTGGNCTCGCGCGGGTCAAAAGO>JNNGNGACCAGANACTATGAANGGNTTT GAATNCATCTTGGCCAAGCTGNAAGGTGAGGCCCNTCCCAAAACCCTTGTTGAANCAGCC AAGGNNGCCANNGAGAANGCCANNGAGACNGNNCTGNCAGCTACNGAGAAGGCCAGGG ACCTTGNCAGCNAGGCAGCCACCAAGAAGCAGCAGCAGNATCANNACGTTCGTGTANCC AGCCCANGCCCTGAAGCANNAANCTAGCAGACTACCANCTCCAGGCCNTGNGCCCCCTTC

TCTTGNACTTTATTATTAAAAGCCANCTNNTATCCCTATCNACTGTCTGGGTGGTGNNCTG ANGGTANGNGCCCTGNTTGGCATTTTCANCNTAGCCAGGTGGGTACCCATATTNGANNCG GGCTTACTTANNCNNGCATANNGTGGCTGAGGACNNATGCNCANAGACTTGCNCACGGCC ACNGTATTNACGTNAAGCGGNNNTGAANGNTATACTGTNNGNTACATGACGTNACGGNN CGACCGATANATCNTCTGATGANAACGGANNTATGTTGANACAANATNTTNTNTGTTNCA

NGCNαsπSfAATANATACTTTGACCGAAATTAATCTGGACCCCTNTTACCAATTAAAGCCTTG NCCCCCACCNCTGGGGGGGGGGCCGGGTGCNGAACCNCCAACCATTGTANTTGGNNCCCN NTAACCCCCCTTANAAANTCCCACTTGGTTNAAACACCTTTTTGGNCCTATTTGGGNTTTC CGGGAGTTTNTTTTTAACCTGGAGCCCCATTATTAGTTTAAATAAAAANGGGGACCCGAA AGCCTTNTTTTACAAAGNCCCTTTTTNTTAAC

GNCCCTTANTAAGTGNAGTCNGANTTNANAGGGGAGNCCGNATTANANNAACTACGTTG GATCNCCCGGGCNTGCAGGCAATTCGGCACGAGGGCCTNTTGAAGCNCNTGCAGTACTGA GCNCCNAAACNGNNATNTATCACTGTGCCACCCANGGGCCCGNACrø^TAGAGANNNNNA

NCATNTNNCAATNGGCTAAAAACNGCTCTTTNNANCGATCTNNGTATTATTTACNNATGN

NCAAACGCTGTNTNAGTTANAANTCTNNTGNTTNACTATTNTTNATTACNTNTTNNNGNN TNNCCANNNANAATGNTN(^TNNANATNANCNGNGNNCTNNNTTANGGNTACTNCTCAN ATNGGCTTNGGTGTNNACNTGAACTNTGNNANTNGNAATNNCNNAGACCGGTNNNGTAT ATTANNANCATNTNNGNGNNTANCTTTCTNTCATCANNANNNTATCCNNAGCGNNTTACN

TANANATANAAATNIWAAAGAGNGNTNNTTCCTGGNACTNAGTNAAGANNNNGAGAANC GNNGATNANANTGACATGNNNNANN(^CANNANGNKTNANGNANTAΛGTTNCGTNNNNN NGANNNNGNNG(^CTACCTNATTNANTNCGNGNNGNNNCNACNANNTANANAGNTTNGN ANNNNNNNANNNTNGNNGNTCNNNNCTTCNNAATGNNGGCANANGGANNTACTNNTNCT ANNNANGNNGGGNTGNNGNNCNNNTTTTCTNTNGTNTTAATNNTAGTCNNTANAANGAN

NTATNTNANNNTNAGGNNNCMWANCNGNANNAAANTAATGTACTNNNNAAAAGNCAGA ANNNNTGGNTNNNNATNTN(^CNGTCGANTACCTNCTAGNQWCANNTTAANNTTGAGG NGAGGNC fTCNGN WαsπSfAGNNCTNT(^TTAAGTNGGGNNTGNNCGNNGCNGNNTANT^ NNNTNTNNNTTTATCNTAGNNGNNNAGCNTANNGGACANNNANGCNGCTNNTNANNTAN GTCNCGCNAATNNNANNNCGNGANATAGCNNATNTNTTATANNNTNNAGCANCAGCACT

ANNGNNCTNNNATNAAANNTNTTTTNANTC^

NAGNATTNTNNCrøvfANNNTTGTNNNNAGGAGCANNNTGCNTGNNTNTGCTNGATATGNTC ACTGTGAANCN

TTNAGCCCTTATAGTGAGTCGTATTACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCTGGACCCCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCGAACAGGGC GACAGAGGCATTAAGGGTCACCGTGGCTTCTCTGGTCTCCAGGGTCCCCCCGGCCCTCCCG GCTCTCCTGGTGAGCAAGGTCCTTCCGGAGCCTCTGGTCCTGCTGGTCCCCGCGGTCCCCC TGGCTCTGCTGGTTCTCCCGGCAAAGATGGACTCAATGGTCTCCCAGGCCCCATCGGTCCC

CCTGGGCCTCGAGGTCGCACTGGTGATGCTGGTCCTGCTGGTCCTCCCGGCCCTCCTGGAC CCCCTGGTCCCCCAGGTCCTCCCAGCGGCGGCTACGACTTGAGCTTCCTGCCCCAGCCACC TCAAGAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATGATGCCAATGTGGTCCG TGACCGTGACCTCGAGGTGGACACCACCCTCAAGAGCCTGAGCCAGCANATCGAGAACAT CCGGAGCCCCTGAAGGCAGCCGCAAGAACCCCGCCCGCACCTGCCGTGACCTTAAGATGT

GCCACTCTGACTGGAANAGCGGAAAATACTGGATTGACCCCAACCAAGGCTTGAAACCTG

GATGCCATTAAAGGNNTTTNTGCANCATGGNAAACCGGGNGAAAAACCTGTNTNTACCCC

^■ ANTTCANCCCANCNTNGGNCCCANAAAAAAATTGGTTTTTTNAANCAAATAANCCCCAAA

GGAAAAAAAAGGCNCTTTTGGGTACNGGGAGAANAACNNATGACCCGGGNGGNATTCCA TTTNTGAATTTTGGGGGCCCANGGGTCC(^ATC^ TTCNNTGGC(^TNNNNNCNNCCCGNGGCCNTCCCAAAAAJSπS[TTTCCCTTACCC

AAAANNGGGGNGNCCTANNTTNGNCαsrANNNAANTTNGGCNANTNTANNANAAGGGCCT

GCCCTATANNGAGNTGTATTACAGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCGGGGGTCTCCGGCCCTGCAGGCGCAAGAGGAGGCGGGTATGGGCCCCAGGTCC CCCTGAGCCAGCCTCCCGAGGAGGAGCTTGAGAGGTTGACCAAGAAGCTGGTGCACGAAC ATGAACCACCCCGCCNANCGGGAAGTTCTTTCGGCCGCTTGGGNGGGTTGCGGAAAAAAA CGTTGNTCGGGGAATGGGNCCGGGGTNGGGGCCTNGANTCGCGNTTTTCNACNTGGCTTG

TTTTGGGNGTTTNAOSINNCNGGCCCNACTTTCGGGNCNANATTTTT^ NAGGNC JNNTNGNAAAACNNGTTNTGNGNCCNCCTNGNAAAANGGTTCNNNN NNTCCN ANCCATTCTNGANCNGANTNTNGGGGCTATNGGGAAAGGCTNNCAACCNGGCTNGTTTAA CTNTGNGGTGTGCCAC(-^GGGGCTCTAAACGGATTTCTTTNACTGTGGATANCCACANAA CCACATATCACTGTGATNTGAGGACANTTCACANAGANAANTTTNCGCCCCAAANATNCT

CNAANATGTGGGNGNGGGCNCATATATGTCCCCNAAAACACANNGTNCNGAGANAGAAC ACCTGGCGAAAATTNATANTTCTTGTGATANCAGNTTTTTTNCAATNTGGNGTGTTACNAA AANGTTGGAGNAAGAAGTTGTGGCTTNTTGGTTCTTCTTTCTTTAGNNGNGAAGAAGTTNA NNANGGGTNTTAANNNCACTGGTGNTGAGGGACCATTTTTTTTGCTANNAAAATTCNTNN NTGNCTTNNTGGGAATANNNANNAAGGNTCTTTNTTANNACCTNTTGGTTCAACCOWCG

NGGTTGNTTGAATTCCNCCAAGNNAGGAACCCANNCTGGTGGGCCTCCTTTTTTTTANTAA AACAAACAATNCTTCTNNNNNANAAAA(3NNCTTTTTTAANANTTTTT^

TTNAGCCTATAGTGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGANTTAANAGCGAGGNATNTNCGNNTGAGNGAANGNANANNGCTGCCTNCGN GTGTGNGNNNACNNTAANNANGTCCTATTTAATTTAGGNNNNTNTGTATCTGGGNNACNA TNTNNNTTCTANNATAAGNGACACCATTAAACGTTCGTTNTTNATATATACNAANNGNNC TTTTTGCCGTGGANGNGGGTTCCNATNTGNCCNCCCNCNACCCTNGNNCCTNTTTGCAAAC CNTCCCTNGTANCNAANNNAATTCCNAAAANGGGNCCAAANCANTNGGGGGNCACAAAG

AACCAACTNGCGGTNNCCCCCCGGGTTTCCCCANCCCAGGTTNCAAAAATTTTAAAACNT TNAATTTGTGGGNAAAAGGNATTCNNCATTGGAGANNNGCCTTTAACANANGGGCAGGG GCCCAANNCNNNACNTTNTTTTNTNGGNTGNTCACNTNTNNAAAANNCANANACGGNTAT TTGTTNTOSfAAAGGNGGGGANAAAAAANCCNCCCNGGNGANATGNAACNTCTTTTNNCG GGGGCNCCTGGAAANAGNCTTNGTAATTACNAAAGAANC-NGCTCTTNCC^TCTNATNNAC

ANNTGNGGNAACCGNGGGTANCNACATTNGNANTAATTTTNNGCNNANTTNAAAACCTGT GGGNNGNGNGGTTNGTGGATTNAAA(^ACCAANNOSITCNTTTCTTNGGNGGGGGGGANN AAAAANNAAGACCCCCCNNNATANCTNNNNGNAAAAAATNATTAAAAAAAGCNNANTCC ACTNAATGAATNAATTNAATCCNCCCTTTTT^^ NGNNGNNTTTTNTNNNTTTTTTTCNNNNGNNNNGNTAANACA

NTNNCCNCGGNNTTTNTCCOSπSlGAGGGGGGTTNNTTAAACCAANNTTNNCNAAAT^ GGGGNCCCCCTCCCCNCGGNCC

TTNAGCCTATAGTGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGANTTAANAGCGAGGNATNTNCGNNTGAGNGAANGNANANNGCTGCCTNCGN GTGTGNGNNNACNNTAANNANGTCCTATTTAATTTAGGNNNNTNTGTATCTGGGNNACNA TNTNNNTTCTANNATAAGNGACACCATTAAACGTTCGTTNTTNATATATACNAANNGNNC TTTTTGCCGTGGANGNGGGTTCWATNTGNCWCC^^ CNTCCCTNGTANCNAANNNAATTCCNAAAANGGGNCCAAANCANTNGGGGGNCACAAAG

AACCAACTNGCGGTNNCCCCCCGGGTTTCCCCANCCCAGGTTNCAAAAATTTTAAAACNT TNAATTTGTGGGNAAAAGGNATTOSINCATTGGAGANNNGCCTTTAACANANGGGCAGGG GCCCAANNO>π NACNTTNTTTTNTNGGNTGNTCACNTNTNNAAA^ TTGTTNTCNAAAGGNGGGGANAAAAAANCCNCCCNGGNGANATGNAA(_^TCTTTTNNCG GGGGCNCCTGGAAANAGNCTTNGTAATTAOSfAAAGAAN(^GCTCTTNCCNTCTNATNNAC

ANNTGNGGNAACCGNGGGTANCNACATTNGNANTAATTTT^

GGGNNGNGNGGTTNGTGGATTNAAA<^ACCAANNCNTCNTTTCTTNGGNGGGGGGGANN AAAAANNAAGACCCCCCMSπsrATANCTNNNNGNAAAAAATNATTAAAAAAAGOvlNANT^ ACTNAATGAATNAATTNAATCO^CCCTTTTTTTTTNGT^ NGNNGNNTTTTNTNNNTTTTTTTCNNNNGNNNNGNTA^

NTNNCCNCGGNNlT TCC(^WGAGGGGGGTTMsfTTAAACCAANNTTNNCNAAATAN^

GGGGNCCCCCTCCCCNCGGNCC

TTNANCAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATNCGG( NCGAGGNTGAAAGNAGGANGCTNTTGNNCTTNNTNNGNACAT TTGGNGANG(^CACAGAATGGGCTTACTTATTNTNNANAANGGANTGAANAANACNNGN (^ACACAAANCACTGANCTAGCGTTAACACGGAAGAGGCGCTGATTNCAGATTNNAAGTC GGGTNCTGTGTGCGTCCANGNAGTACACNTTNGNGCTTGNGAAGGGCTTGNATGGTGCTC

ACCTNAAAGCATNAGGGANCCANNAANAANGNNATCAGNTGCTGAGCTNGGTNAATGTN ANTNGAACTNATTNTTTCNNNCACGNGAAATTGNTCTTTGGTATGCCCCNTTGNANTGANT AAGACCTGTTCNNAAACTTGGNANCTTNATNCATAATGCTGAAGGCAGAAAATCTGTTGA GGANAATTGCANGAGGGAAGGCTGCTTTGAAAGCGCCTNATTCTTTTTTCCAAACACTGCT TCATTCNCCAATATNAATATGATCTTAAAAAGTGTGNAAATGAATANTGNTTAANGTCCC

AATTGTGCTTTTAGAGGGGGGCGNACTGATGCTTAAAAAATGAATTΓTTGTTNTAATTACA AANACTGGTATTATNCNGGGGAAAAAGTGGGTTCAGGGTACANTCTNGGGGAAAAACCN

ACCCGTNTGCCTNTTNAANCCTAAAAATTGCATNAACCTTTATNTTNTGATTCAAAAAAAA AGGGCNCNCTTTTGGNTTTTTAAAAGTTTNTANAAACCCTGGNCCTTTTTAAGGGGT^ GNTITNAAAAATNGGGGGGGTTGTTACCAAACAAACAAGTTNNTTTTTGNAAGGGN^

NGGGTTTNCCC< NTTAAANNGGGGGGGNGGCCNGGGTTTANCCNTCNAAAAAAANAGNC CTGGGGTTNNCCNT

GANCANAGCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGANCCCCGGGCTG

CAGGTTCCTCTCCAGGTCTTTNNTGNTGNCAGAGGTGGGGGTACGGTCCAAACCCCATTA GGTCACTCCGGCAGCATGTGCTTTTAGCTTCTCTCTTGACTAGGAGTCACATATCCCTTTGT CAGCTGGCCTTCAGCTCCTTNGNTTCTGNGTATAAACCTTGGATATTACNGNNTTTTATAT TTACCAGAGCTATTCGAGCAANAGTATTNGAACCACTAGCCTTTGAAATAAAAGNCAGCC CCGTTATTAACAGNGCAGATACTGAGTCCACTTGGATTTCTTGCAGCTTTCTTTGCACTGCT

TTAGGCAAAAAGNGTTCATCTGGTTTTTTTCATTTGACACCCCAGTTTGCTGCANNGACAG AACTTANTGCCTAATCTGTAGAGTTCNTATATATNTATATAAAATATATTTNCCCNCNCTC CNCATATATATATGAAGTTTAATGAACNGGNCAAGNGAAACATCCTAACTGTCCTTGGGA TAAAGGANCCAGTTTTGCAGGCAGCCAGCGCGGGGTTTTTNTGTNGGTCTCCCANCACAT GCCCATTCCTTTGCCCGCCCATTCCTGGTACACTCGANGGGAGCTGGGGGACNCCACTGG

GAANGTTTCTGNGGNCCTGTCTTGAATGNGGCAGGCTGGAGGGGNCCCCCCCAAAGNGAN CTGGGGCGTTTTTTGTTCCCCACCCNTTTTAAACTGGTTA(_^GGCAGGGGTNCCGNCC(^C CCCCCCCCGTCAAAAACAAAAGTTTAAAGGGGGAATTTTGGGGGGNGNACCCTTTACCCC CCGNAAAAAAAANCTTGGGGAAANCCNGGAANΉCCGGCTTTTAANNAAATTTTGGGNGG ^TTTNAAAAAAAAANNGGCCCCN

TTNNNNAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGGGCAGGCCCCGGTGAAGAAGATCCAGGCCTCCACCA TGGCCTTCAAGCAGATGGAGCAGATCTCCCAGTTCCTGCAAGCAGCCGAGCGCTATGGCA

TCAACACCACTGACATCTTCCAGACTGTGGACCTCTGGGAAGGAAAGAACATGGCCTGTG TGCAGCGGACACTGATGAATCTGGGCGGGCTGGCGGTAGCCCGGGATGATGGGCTCTTCT CTGGGGATCCTAACTGGTTTCCCAAGAAATCCAAGGAGAACCCTCGGTACTTCTCGGACA ACCAACTGCAGGAGGGCAAGAATGTGATTGGCTTACAGATGGGGACCAACCGCGGGGCTT CTCAGGCAGGCATGACCGGCTACGGGATGCCGCGCCAGATCCTCTGATCTGCTGTGCAGC

CCTGCCCCTGCCCTCCGTGAATGGTTAATATATATGTNGGTTTTTTTTTTTTTA^ NTTTCCTTGANAGCCCTNGGANGCTTTCGCNCTTCCNTTTTGCAAGGGTTGGGGCCTGGCC TNTTTTTTTCCGGGGGGGCCCAACGGGGGCCNCCCCCTTTGGGNTAAANAAAAAAATTCC NTTTTNCAAANCCCCCAAAATNGGACCAACNGGCCTTTTTTTTTCCCCTGGACA^ NGGGGGGGACCTTTACCCCCTTTTCGGAAOSΓAAAACTTTTTTTTTT^

TNCCCTTTTGGAACCCTTGGGGCCCNAAAACCATTTNNTTAAGGGGGGGCAAAAAAAGGA TNNTTTNNTTNAAAGGNTNTTTTTCCCCCC^

GGGGGGGGGGGGGGGCCTTTANTTTTTTTGGGGGGGGGGNCCTTGGGNCCCCCCCCCCCC CCCCNC AAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GAATTCGGCACGAGGATTCATTCACACCAACAACACAACTATCAATAAACCTAGGCATAG CCATCCCCCTGTGAGCAGGAGCCGTAATTACAGGATTCCGCAATAAAACTAAAGCATCAC

TΓGCCCATTTCTTACCACAAGGAACACCCACTCCACTAATCCCAATACTAGTAATTATTGA AACTATCAGCCTTTTTATTCAACCTATAGCCCTCGCCGTGCGGTTAACAGCTAACATCACT GCAGGACACCTATTAATTCACCTAATCGGAGGAGCTACACTTGCACTAATAAGCATTAGC ACTACAACAGCTCTAATTACATTCACCATTCTAATCCTACTAACAATTCTAGAGTTTGCAG TAGCTATAATCCAAGCCTATGTATTCACTCTCCTAGTCAGCCTATATCTGCATGACAACAC

ATAATGACACACCAAACTCATGCTTATCATATAGTAAACCCAAGCCCTTGACCTCTTACAG GAGCTTTGTCTGCCCTCTTAATAACATCCGGCCTAACCATGTGATTTCACTTTAACTCAATG ACCCTGCTAATAATTGGCCTACCAACAAATATACTAACCAATATACCAATGATGACGAGA TGTTATCCGAGAAAGCACCTTTCAAGGGCACCATTACCCCAGCTGGTCCAAAAAGGCCTC CGGTATGGAANAATTCTTTTATTATCTCCGAAGTACTATTCTTTACCGGATTTTTCTGAGCT

TTNTACAANTAAGCCTTGGCCCCCANCCCTGNACTANGNGGGTGNTGGACCCCCAACAGG CNTTCNCCCCTTAAACCCCCCTAAAAGTCCCACTGGTTCA

NGGNNGGOSfTTTNNNNNNN!S[NNNNNNNNNNN^

(.MSrøTCCNTSINCCαSfCTCCTNAN^

TGATCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGTTGAC ATCTATGAGGACTTCCCGGATCTCAACTCGGTGCTCTGGGGAGCTGAGGAGAGGAAATGG GTCCCCTACCGGGTGCCCAACAATAACCTGCCCATCCCTGAACGCTACCTCTCTCCAGATG CCACGGTATCCACGGAGGTCCGGNCCATCATTGCCTGGATGGAGAAGAACCCCTTCGTGC

TGGGGGCAAACCTGAACGGTGGCGAGCGGCTTGTGTCCTACCCCTATGATATGGCCCGCA CACCCAGCCAGGAGCAGCTTCTGGCTGCGGCCATGGCAGCCGCCCGGGGAGAGGATGAA GAAGAGGTATCTGAGGCCCAGGAGACCCCAGACCACGCCATCTTCCGNTGGCTNGGNCAT NTCCTTCGCCTCTACCCACCTTACCATGACTGAGCCCTACAGGGGAGGATGCCAANCACA NGACNACACTGGTGGCATGGGCATCCNTCAATGGGGCCAANTGGAAAANCCCGCTTCTGG

GAACTATTANCCGACNTTCAGCTACCTTGCACACCCAACTGGCCTGGAGCCTCNTCCATTC TTCACTGGGGCTGTNGATCAANTTCCCCNCATNGANAAGCCNAGCCTTGCCTCCCCTAAN NGTTGGGNANTAATCAATACNATAGAAAGNNCNTNNTGCCTCANCCCTTTCATGGNNAAT CCANGTTTNTCTCCGTGGCCATCNANNGGGGGNGNNCTNGNGACCATCACCTANNCCAAA GGGGCCATCCCCCTNAATANCCCNNATNNCCTCCCNTTTTTCCGNGTGCAGTNNGGNATTT

ANNCCCCCGGGGGTCGGGAAATCACα^TGCCCNTCGNGNTTNNCNATATNNGCCTTGNGC MSINCATNTCCNTNAAACCNCCNGTTNGANNATNTCNCTGNCGGGANCNGNNCNNCNCNTC NGTNANGGNTCTTANCNCCTCTCTCTCNCTGTTCANANANACNTCTGNCTANNNCGTGTGA ANTCANNGANACNTTCGCO NTNCNCCTTCTO^ GCTCCTCTCTNCCNCNNATAGGGTGAGACGCTNNCTCNCGCTGNTTNGATNCAGTGTGNCT

CATGTNNCATNTGNTCNCACCC

GCCTATNNGGAGNTGNATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGATCGTATAGAGGAAGTTCCTGAACTTCCTTTGGTGGTGGAAG

ATAAAGTTGAAGGCTACAAGAAGACCAAGGAGGCTGTGTTGCTTCTGAAGAAACTTAAGG CCTGGAATGATATCAAAAAGGTCTATGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAGA TGAGAAACCGTCGCCGTATCCAGCGCAGGGGACCCTGCATCATCTATAATGAGGACAATG GTATCATCAAGGCCTTCAGAAACATCCCTGGAATTACTCTGCTTAATGTAAGCAAGCTGAA CATTTTGAAACTTGCTCCTGGTGGTCACNGTGGGACGTTTCTGCATTTGGACTGAAAGTGC

TTTCCGAAAGTTAGATGAGCTATATGGCACTTGGCGTAAAGCAGCCTCCCTCAAGAGTAA CTACAACCTCCCTATGCACAAGATGCTCAATACAGACCTTAGCAGAATCTTGAAAAGCCC AGAAATCCAAAGAGCACTCCGAGCACCACGCAAGAAGATTCATCGCAGAGTCCTGAAAG AANAATCCCTGAAAAACCTGAAAATCATGTTGAAGCTTAATCCATATGCAAAGACCATGC GCAGGACCCCATTΓTTTCGANAGGCCAGGGAATCACAAAATCCGCATGGATAAGGNACAG

CAACCCTTAAAAGCCAAATCAAATCNNAAAGGGGTTCAGGGCCAAAAAACCTTGNNGNT NGGNAAACAANGAAAAANAAAGGCTGTTGGCGAATAAAAAACCTGAAAAAANCCTNGG GGNGGGAAAAAAAAGGNTGCNNGGGGACCCAAAAAACCCCCCCTNTTGAAAANAAACCC CCANAAAAAAAAACCCCCCTCANANGAAAAAAAANGNGNNGTGGNGNAAACCTNAAAA TTGGTTTATTCCATAAAAGGCCCAATTTTTTTGGGGAACGNNN

CTNTNAGANGGGTGGANGTNTGC^GTGNGNCNAACNNNNTCGTNTACNGCCCTCATCAGG

GAGCCCGNATNACATGGGΑSRGGCCGCGCCCCAATAACTTAGCCGGCTTCCCCCNCGCTTC ATTTT(^TGCAATGGCTCANATOWTNTAAATCTGTNCCTCCGNTNTGCNTGCNATΑWNT TANCTGTGTCTCTCGGNGNNNNCCNCATCACGGNCANCAGNCNCNTCATGCANAGGGCGG

ANACNCCCNCT WTANCNCTAGNCNNNGTNNNNCTCCCCCCC I(NNTTCGNCNTTCNCGCN ATATATGGNNTNNAGANTTTTTGNATNCGNNGGCNCTCCCAGACACGCNTTTNTNTCAAN

TNCGNTNCTNNGAGACNGNANCCGGNNTCGCNGCNTTAATNNACTAGATNTNNCNNNNG NGNCANTCTCNNANANTCATNTNCNTCTTATCTNNANGCGGNNGGACNGAATGNNTCNAA TANATTCACTAGCGGACGNTNTNGTAAATAGACTCNCTNNANNGNNNTNGNNTTCCCTNG TNCTGGCNCNAANNNTNTTNATCTNNGANTN^ NTTGNATTNTNTGANNNANCGNCNNNANCGCGNGNNCNTTNTGNTNNGT(^CANCCRØVICT

NACCNCCNNGNNACGANCGGGTNNCTNCTAGTCANNNACNTTNNATCNNTCAAGTCCGA GNTACTTNNATNGTNTCCNCTNANNATNTNNTNOSΓGNTATNNNAANTTTGTCATGC ANNGCCTACTNGCGCGANNNNTCGNNNNNTCNNNCNNGACCNNTNCTANTGATCNTTGN GCNTTNATCACTNNNNNGCCTGNCGCCNNNTNTCNGTNNCTNTNTNNTGTGTNNCNCGAC GTAGNCCNTCNTGTTNTNNNNTCGNNGCAACNNCTATNCCNTNGTGCTNCNCGNCTNAAT

NNTCTGANTNCATNANCTCTTCNTCCATNTNCCCCNNCACCCAGGNNNCCCNNNCTCNTCE TNT^M TTCTTTATCTTAAACCTNNNCANNCACAGNGCTCCTTCTCNCNANCCCCTTCNNT TTTTCTCTCNCGNOSINTGGNCTCNNT^ GCNAATATGTGGNGGCGNCGTANCTGNGATANNCNTACNAACTANTCTNATCTANTCNNN ANAGNACAATAACTGCTGATGTTTGTANNNCGCTNNCACTNCANNCTNANTCCGGCTNTN

NGGNNNTCNCAGNGTNTCGTCGTTNGANCANTATGACNTATAACTACNACTTTATGCTNA GTNACGANNGCTNNNAGATCATGANANNNTAGAGTNANTANNGNANACNTCNTNANNCN AGTATACGNCNCATCNNCNTCNACΠSRGNTTNATGTNTCTNNTCTTTNGTGATNCTANTNAT NCCTNTNTGANNANTCNCANNNGCGCGATCCCTCGNANNNACAAGAGNTATTCTCGTNAN ATANTGNCACNCACCTCTNAGNGACTNANANCCG

TTNAGCCTATNTGGAGNTNNATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCNCTTCGGTATCTGCGGGCCCCGGTGCAGACATGGCCAAGTCCAAAAACCAC ACCACNCNCAACCAGTCCCGAAANTGGCNTAAAANCGGNNTNANAAANCCCNGNTNNCA

NCNNTTTNANTNTTTTANGGGGGTAAACCCCANNTT(^TGAGNANasrTNCCNTTNGCC AAACCCCACCAGAAAGGGCNTGAAAAAAATNCAGNCCACCATNGCCANGGCCTTNATNG CCTNCNTGAGGTGTGTNAAGGCCTTTGAGAAGCCCAAGGAATATCAAGCCCAATANGCCA ACAGTGTGGCAGCG(^AACTCNNAACGNNTTTTGCTATATATCTCTCACCANACTNTGGA AAAGCGCTCTNGNTCTCATATCCANAGGGC^CTTNNTCTGTNGNGNACANNGTCNCNGGC

NAGGNTTTANCNNAGGNNNANCNCNNNTGGGNGTGGGTCTCCATGTNCNAGGGGTGCCC ACGCCCCCACCAAATCTGGNGAGTAGANCNTTTCTCTGCCAGTGTGAAGACAAANAAGTA NTGGTGACACCCCCTGGGCTTGTTNTCTGCGNGGNGCTGGNNTCTTGCTGTGCTNTTTCCA CAAATNAATTNTGNANAAAGAAAAAAAAAAAAAAAAAANNNTTTTGGGGGGGGGGGCCC GCCC<^AATTTCCCTTTTTTGGGGGGGGGTTTAN^

NNNNINTNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNM^ NCN

TTNAGCCTATNTGGAGNTNNATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCNCTTCGGTATCTGCGGGCCCCGGTGCAGACATGGCCAAGTCCAAAAACCAC ACCA(^CNCAACCAGTCCCGAAANTGGCNTAAAANCGGNNTNANAAANCCCNGNTNNCA NOWTTTNANTNTTTTANGGGGGTAAACCCCANNTTCNTGAGNANCNTNCCNTTNGCCAA

AAACCCCACCAGAAAGGGCNTGAAAAAAATNCAGNCCACCATNGCCANGGCCTTNATNG CCTNCNTGAGGTGTGTNAAGGCCTTTGAGAAGCCCAAGGAATATCAAGCCCAATANGCCA ACAGTGTGGCAGCGaSfAACTCNNAACGNNTTTTGCTATATATCTCTCACCANACTNTGGA AAAGCGCTCTNGNTCTCATATCCANAGGGCNCTTNNTCTGTNGNGNACANNGTCNCNGGC NAGGNTTTANOSINAGGNNNANCNαSlNNTGGGNGTGGGTCTCCATGTNCNAGGGGTGCCC ACGCCCCCACCAAATCTGGNGAGTAGANCNTTTCTCTGCCAGTGTGAAGACAAANAAGTA NTGGTGACACCCCCTGGGCTTGTTNTCTGCGNGGNGCTGGNNTCTTGCTGTGCTNTTTCCA CAAATNAATTNTGNANAAAGAAAAAAAAAAAAAAAAAANNNTTTTGGGGGGGGGGGCCC GCCCCNAATTTCCCTTTTTTGGGGGGGGGTTTANANNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NCN

TNNNACAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGTTTGTCACCACAACAGGCTGGTCATAACAAACACCCTTTTCCAACAACCTA

GTAGACGTCTCTACACATGGACATCACCAGATGGTCGATACCGAGATCAGATTGATTATA TTATTTGTCGCCAAAGATGGAGAAGCTCTGTACAGTCAGCAAAAACAAGACCTGGAGCTG

ACTGTGGCTCAGATCATAAGCTCCTTATTGCAAAGTTCAGGCTTAGGTTGAAGAATAATNC CAAAANCGACTCGGCCNTTCAANGGGATTAANGANAAGGATGCCNCAAATGANNAANCA AANTCCGTNTTAANGCANATNGANAANNAAAACΑSΠSFGAGGTTACCGTTCCTTCACCTGGG TCNTNAGTTCTTGGGGGGTCAGGCNTGANTAAGGAGGNGGGNGAACCATNTCAGGAAGC GAATTNTGTGTTCAGGCAGGATGAGAAAGACAANCCTCAAGCTAATGTCCCCTCAGNGGG

GCCATCACTTCTNGTNGGGCNAGGCCNTGAAAAAGGGGCCCTNGAAAAGNAAAANGGAT GGCACCANTTAAGTNTTTGACTTNGNCCTTAANCCCCTAAA(_^GGTTTGTTTAAAANACAG TGGGAANCCGGGTTTNGGNAACCTTTΓCCGGTTGGGTTATCNGGNAAACAAAACAAAANT TGTTNTTGGTTAGCTTGNTTTGNAAAANAAATTTTNGGCAAATTAAAGNCTTGGACNTTΠ TTNAANGGGGGAGNTTTTTNNTTTGGGANGNGNAANGGGTTAACTGGNCCCATGGANNTT

NATTGGGGCOSIGGGGNTTTTTTGGATTTTAAAAGCCAATTTGGCCCCTTTNGGGNΠ GATNAAAAAATTAGNCCCNGGGGNAAANCCCNTTTTTTTCCCGGGGGGNTNCCCCNAAAA AAAAAAANNTTNCCAAANGGGTNC

TTTGANCACCGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGACCCCCGG GCTGCAGGCAGGANCAAGCGATTCCNGGCCAAGAAACAAAAGCAGAANCGNCCCATNCC TCAATGGATTCNAATGAAAACTGGCANTAAAATCAGGTACAACTCCAAGAGAAGACATTG GANAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGTCTTAACA TGTAGACCACTTTTTTAAGCAGCCAGATCACATTGAAAACATCACTNCTGTATTGCTTGGC

CCATGATGTTATTNCCTCACTATCAGTCTGAGACCCAGCAATAAATATAAAACGTGCAAA AAAAAAAAAAAAAANTTNGGGGGGGGGCCCGGCCCCANTTCCCCTTTAAGGGNGNTTTN NAAAAANNlSπSlTSπSlNCCNNNCCTNNNN]SINαSlNNN^ NNNNNNNNTCTNNCNTNTNNMS1NNTCNCCNNNNNTCTN NNTNTTNTNNNTTCTNCNNNCOSINNNTNTCNNNNTW

CTNNNNNNCTNNCTTNNTMSπstNNNTNNNNTN^ NANCTNt-^INNNNNTCTNCCN^

NNNNCCNCNCTNNTNTTNTTTNNNTC^ NNNNNCCCNTNTIWTT<_M^^

TNCNCCTNTTNTTNTNTTNTTN^ CNNNNTNNTNCCNTNNTNNTTCCCNNNCTNNCCN

TTNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCTATTTCAGTGGAACTGCTGATAGCAATATGTCTTCA GGGAATGCCAAAATTGGGCACCGTGCCCCCCAGTTCAAAGCAACAGCTGTTATGCCAGAT GGTCAGTTCAAGGATATCAGCCTAGCTGACTACAAAGGAAAATATGTTGTGTTCTTCTTTT ACCCACTTGACTTCACCTTTGTGTGCCCCACGGAGATCATTGCTTTCAGTGATAGGGCAGA AGAATTTAAGAAACTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCTCACTTCTGTCAC

CTGGCATGGATCAACACACCCAAGAAACAAGGAGGACTGGGACCCATGAACATTCCCTTG ATATCAGACCCCAAGCGCACCATTGCTCANGACTATGGGGTCTTAAAGGCCGATGAAGGC ATCTCATTCAGGGGCCTTTTTATTATTGATGATAAAGGAATCCTTCGACAGATCACCATAA ACGACCNTTCTGTTGGNCCGCTCTGNGGATGAAACGCTGAAACTAGTTCANGCCTTNCAG TTTACTGACAAACATGGGGAAGTGTGCCCAGCTGGCTTGGAAGCCTGGCAGTGATCCCAT

TCAAGCCTGATGTCCCANAAAAACAAAAGAATATTTΓTTNTAAACANAAGTGANCCGCCT

CGGNCCGTTTTAANGGNCCAGGCTTGCAATAAGGCGGGCCTTTNAAAAACAAAAACCTTN

TTTTGGGCCCTAATTTTTGGGGCNTNAAAAC(DN^

TGNGNGGGGGGAACAAGAA(^GGCCCTTTTCCTTGCANGGGGTTGGGGGACCCCCCANCC

NTTTTTITCCTTTGGGACGGGAAANAACCTGGGCCC<^^

GGGGANGGG

AAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GAAGCGATGGGCATCTCTCGGGACAACTGGCACAAGCGCCGCATACACACAAGAAGTAC CGGGCCTTGAGGCTGGACGTGGGGAACTTCTCCTGGGGCTCGGAGTGTTGTACACGCAAG ACAAGAATAATCGATGTTGTCTATAATGCATCCAACAACGAACTGGTCCGTACCAAGACC CTGGTGAAGAACTGTATTGTGCTTATCGACAGCACACCGTACCGACAGTGGTACGAGTCC CACTATGCACTGCCCCTGGGCCGCAAGAAGGGGGCCAAGCTGACTCCTGAGGAGGAAGA

GATTTTAAACAAGAAACGATCAAAGAAAATTCAGAAGAAATACGATGAGAGGAAAAAGA ACGCGAAAATCAGCAGTCTTCTAGAGGAGCAGTTCCAGCAGGGCAAGCTTCTTGCATGCA TCGCTTCAAGACCAGGCCAGTGTGGCCCGAGCAGACGGCTATGTGCTAGAGGGAAAAGA GCTCGAGTTCTATCTGAGGAAGATCAAGGCCCGGAAAGGCAAATAAACCCTCTTCTCTCC TGTCTΓAGCTCATCTAATAAAGGCGTTTACTGTTCTATGCCAAAAAAAAAAAAAAAAAAT

TNGGGGGGGGGCCGGGNCCCCATTTCNC(^TTΓAGGGGGGNNNNTANNANNNNNNN^

NNNNNNNNNNNNNNNNNNNN1>ΠSINNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^^ NNNNNNNNNM^WNNNNNNNNNNNNNNN^ NNNNTSINNNNNNNNN

NNNGCCNGCCNTTTNNNTCNNNNNNNNNNNNNCNNCNNNNNC TNCTNTTCCNCTCNCCNNGGGNNTATCATNNTGCTNAC3WNTTCAGCCTNTATGATCGTAT ACAATGGCGGCCGCTCTANAACTAGTGGATCCCCCGGGCTGCAGGNAATTCGGCACGAGG

CATACNTTTTAACCCAAGCCNCGACNTTCTTAGCTGNGCCTCAGCTCTCACGGCCTCTNGC TCACCCATGAATGGACCCGCTTTCCTCTTGCCGAGTGCACCTCCACCCATTGTCTTGGTGG CACATGGGTGGAACACTTGATCTGCTCGAGTCTGCCTTCAACACACATTGCATCTTCAGAT TTTCTACTTTNCTGTTCAAAACTAACATTCNCCAAGTCAGACTTTGTGNNACNTCTATNTC NCGGTCTNCGGCGTGCCATGNGNTTCATCCCTANNTNGTCCTGAANATGGACNCATGGGA

ACTTNACANG(^CNTGNNTGNTNGGCACANGANTGCTTTTAGNGGCTANNAGNGNTCNAT NTGCNTGGNTAGCATNNGCTTGCGTGAATNCCTCCANCCCCCGANACNTGCTTTATANCTG ATTTNTTTNANGGGNCNNNGGCCNCCTNNGANCTAGTNNATAANNCGNTNNCCGNACTGT CTNGININNTACCNNACCNTTNCNNTCT^ ANCCATTTTCCNNTTACNTTANCNNTCTGCTATNCGCNCNNCTTNTNTCTCTTNGCTCTCCA

CCCCTANNTTCTNCCNTNCCAGCTNNTNCTATTTATCTTNTNGTNTNCTNTCNNTNCCGCTC NCCGTAATTNNNACANNCCACTTTCTCGCCCNTAGNTNACTATANCATACCCCTTTCCTNC NTNGACTCTGNNTTCCCCCNTTOSfATNTCNTGCCTATTNNTTα^TCGNCATNCGCTTCGGA CGNATCGTATNNTNTTCNTNTCATTCTCT^ NNTTNCGNANTNNTCCTNGTNTCTCTCTCTCCTACTTCTANNGGCNTNTTCNCCTCACTATT

NNTCTCTCTCNGCπSfNCGCNTGGNAGANATTCCTGACNTNTGNGCTCATTTATNCCNTCNGC CGCTNGGGNNT(^ANCTNACTANTCTCANACCGNTTCACTTNCCTANNTNTTNTTNATNTC GGTCGGNCTNTCTNTNTANTNACCTNNANNACNANATGTCCGCGCGTCACGNNNNGTATC TCCNTCTCTTCTCGTNTGATCTCNTCNGNATGNGTTGTCNNTCNTTGTCAGCTTACTCCTTC TTTCTCCC

CCCCCCCCOSfNCTNNNTANNTANTTNTTTTTTTTTN^ CGNTCTNNCTNCNCGNNNNTCCTNTTC^ NTTTTGAGCC(_^ATATGAGTCGTATTACANTGNANGCCGTTNTANACCTGGCGGNTNCCCC

TGGGCTCGCTGNAATN(MNGNNCGAGGCT WCTCT^

NTCTGNGNACCTCAANNC ΪNCCNGCCTCTTATTNNCCCNAGNNTNTGNNGTGCTTCTCTCT TNGTTGTNNTGCGCNCGTCNNGCCGTNTTCCCCTNNCNCTCCTCNTTGGTCNGCTNACTAG ArlNNANCNTTNTNTNNCTATGCNCTN(^^ NCCTTTOSfGNNTATNNTTNTNTCTCCTTANTNTCTGNTACTCNCNACNCCCCCCNGAGNNN TCCNCCCCTNC^CANTNTCTNNTANNTTCCTGNTCTCNNCAACCTTTCCNCCTCTTTCCCAC NAGTTCC^πS[TTCTNATCTCTTN TNNATTCGTCCTTNCTCTACNNTTTCNT^ CTTCANTCTNC ^GCTTCTTTOTC^^ TCANCTATNT(^TCGCTCGCCTCTCATGCTTCCTTNGTCNNCTCNCCNTNCNNACCNCCNC

MSTACNCCTNANTTTCNCTNCCTC^C^ CTTNACNTC GNNNNTC :a^^

NCTTNCTNATCTTCTTCNTNCCTGACGCTCCTCGNTGTCNNCTTTNACCCNTNCGTCCCTCT CATGTCNCMvTCCANCCMvrCCCCANNTC(^TNCCNTGACTCTCTNTCCCCTCNNCCCTGTGA TCNa NTCCTANNNTCCNT(^(^ACCNCNTNNACTNCNNCaSINGNCClTSfCANCTTAN^

NNTGTNNCTCACTCNNNTCNTTTGACCCACTANNCGTNNCCTCTTCTCCTCCNCTNTCGNT TAC ΪTTCNNATTATTTCCTGNCCNACAACN^

TNCCACCCCTNTANGTNNNGCTGCT(_M TTTTANC(^CTTATCTATTCCTCCNNTNCTCACC TATNNGNCCNCNTCTCNGATCTNCNAGTGCTCTCCNTCGTCNNNGCCCCTTAAGTGTTNTC TCCTNTTNNNTCTCCACTGNCTCGTCTNNGTCTCCTNCGTCNTNTAANGTANTNCCTCNTC

NGTCCTNNTNTATCGTACCCATGNTCTCNCNGGGNNACISπNrCCTTACTTTACNCCATCGCGN CTAATCTCNTCTNCCNTCTNTTCGNTSINCCNGATNGNCACTCNTCTTCTGTGCTAANNNCAG CGCNNGNTACNCANANTNGTGNTNTCTNCTCTCTNNTCCTACNCTTCNCCGNNCNCACNN CATNAATCGTCGTTCOSπSlNNNTCCNGCAGNTGAACπWATCTCTNNTTACCC

CTCGCTCNNAGAAANGNGGGGCGCNCGNANCGCTNCACGNCCNCTNCTAACNCNTACTN NTAGCCCCNTATCAGATGCAGGNTCGTCATTACAGNGGCCNCNCNNCCCTANCGCACGNN

ANNTGNTATCCNNTC TSπsrCNNTNNAC^^ GTACTTNTATCTAANCCCCANCCTACTNGAANGNGGGCCCCTACNNNNCCGNANNNNNCN

CACCGTNN(^ANCTGNTTTNANACNCCNNNNNNCTNTATGTTNAACNNNGNCNTNTNANN NNCNANNNTANTNGTNNGNNAATTNNNNNATTAGTGNACCCANNNr^NNGCANN^ ATANTTTNNNTNNNNN JNGNNANTTCNNNGGCNCCCANCNN^ NTNNNGGGNANGAA^INGNTGNANTNTNTTOT ATTTNNNNNNCATGI IN JNNNGGNCCACNNNCATCATATGNNTNNCNNANGGNCTANTCA

TTCNNCTCNTGNNNANNNTGATNGANTTNNNTNANTNCGATTCGGNNGGNNAGANTNCCA TTNTNNTANACGGNNNACGTNNGTCGNOS[GNACNTTNTNNTANTTNNANANNGTNT^ NGGGNNCTGNCATATNANTTTCTTNACTGATTGGTCNTNGCOSITGNNNAACNACTGCNTN CTGNANTlSlNlSiNCANNNNCN GNCG NAACmOTATTCAATTTNNNNNTCANTNC^^

TCNNNGNNGTGNCNGCTNTCNGGGNNGNNATGTANANGNNNTGNNCNCATNNGANGAGA CCNAGTTCTNNTCTCNTCNACCACTCATN<^TTNCNATTNTCNTCTTCCCNTCGTO>fNNAT CTCNCANTNNATNTACCAATNCNAGACCTCNTNNNCACTTTTCCCAAOS1GACNANAATTG NTTCTTGTT(^ATANAANCTNTTNTAANC^AATCGAANANCACNNNNNGTNANTNTGTTC AGTNNTTCATCTCATATAGNAATNTCANNNTNANNCTTTNTNTGCTGCNNTCTANTGATNA

CGATCNACTTNNCTGATNTTACTNGCTGANNAGTTGTAAGNGNNACAACNCTGACTNTAN TACTCTNGNNATGGANTNNNTNGTNCNCAGANTTGTAGNTAGCGCCTCNCTGNNAANACT NGNCTATNANAGANANTGNAGACAANNCNAATGTAGANNGTGNNAACNCTNCTGACNAC TlNlNACrrTACGTCANTTNCTGATNCTNTNANTGNCGTNTCACTGTAGANATGTANNGTGNN NAGAGTNGATACNTATCTCAGANANGATANTNNGNGAGNNACCNNTNTNATAGAATAGT

GTNCTGTNCNATNATANTNTNCACTCTTGTTNCANANCGTGNCG

TTNANCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGTATAATCAAAAGTGGGTTAAAAAAAAGCTGGGTTAGG

GCGNGNGTNCNCCTTGAAAANGTTCTNTTNANCANTGGGGNCNTGNGTNTCNGGGGNAG

NACCTTTTTTTTNCOSrTANGN AAACNNGGGGGGGGGCCCNGGCCCCNATTCCCCCTNATGGGNNGCNNNTTANNANNNNN

NNNNNNNNNNNNNNTSINNN^ NNNNNNNNNNNNNNNN NNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNr^NNNNNNNNNNNNN^ NNOST SINNNNNNNNNNTNNNNNN ^ CHNNNNNNNNNNNNNNNNNNNN(.^^

NNNNNNNNNNNNNCNNNNNNNNNN^

NNNNNNNNN(^OS[NNNNNNNNN^

NNININNNNI^NN NC^^

ISINNNNMSπsiNNNN^

TTNANCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGTATAATCAAAAGTGGGTTAAAAAAAAGCTGGGTTAGG GCGNGNGTNCNCCTTGAAAANGTTCTNTTNANCANTGGGGNCNTGNGTNTCNGGGGNAG

NACCTTTTTTTTNCCNTANGNNNCCCCANTAAN^ AAACNNGGGGGGGGGCCCNGGCCCCNATTCCCCCTNATGGGNNGCNNNTTANNANNNNN

NNNNTSTNNNNNNNNNNNNNNNNNNN^ NNNNNNNNMSfNNNlWNNNNNNNNN^ NNNNNNNNNNNNNN^

NNNNNISITSINNNNNNNNNNNNN^ NNNNNNNΠNI IS^^ CNNNNNNNNNNNW N NNNNNNTS^^

NNNNNNNTSπSTCNC^

NNNNNNNNNNNNCNNNWCNNNNNNN^

NNNNNNNl>πSlNNNNNNNNNNNNN^

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCGCCCGGGCTG CAGGCTGGTGATTCTTAATGATTTGAAGTCCATTGCTTGGGAGGAAATTCCACCACACATT CATGCTTATAATAAGCTGGGGATTTTTGTTTGTTTTTGCAAATGCTTGCCCCTACTTTGCAA CGATTTTCTGTTCGTAATTCTGAAGAACCAAGGTGGGGAGCAACACAACTGATGGAATAG TGGTATAAGTTTATACCAGAAGCTTAATGACAAGTTTTATCAATCAGAATAATACTTGGTT

ATGGAAGTGACTGATGCTAAATAAATTCTGAGTATTTTTTATTAGATAATTTCTCACATAT AGACTTAAACTGTCAGCTTGGTAGTGTCTATTAGTTAAACTTTGTAAAATATATATATATT CTTGTTTTTCCATTGGATGCAAATTGAAAGAAAAAGATGTACCATTTCTCTGTTGTATGTT GGATTATGTAGGAAATGTTTGTGAACAATTCAAAAAAAAAGATGAAAAAAATTCCTGNGG ATGTTTTGNGTAGTATCCTTGGCATTTGNATTAATAGTTAAAGTTCACTTCCAAATAAAAC

TCCCATAATGCTAAAAAAAAAAAAAAAAAAACCTNGGGGGGGGCCCCGGNCCCCAATTC CCCCTNTTGGGGGGGNTTNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNMSπSINNNNNNN^ NNNNNMNNNNNNNNNNNNNNNN^ l^WNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^

TTGANCACNGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGACCCCCGGG CTGCAGGAATTCGGCACGAGGGACCGTTATTGCTCTCTTCCTATATTGTAAAAGTGCTCTT

TTTTAAGGTAAGCATCAGCCTTGCTGTCTGTAGATCTTCTGAGCAACACTATGTACACTGA TACTTGGTTCATTTAGCTCTAGCAGTACAATGATTAGTAATGTAAAAGTTANCCTAAGGAA GATAGCATGGATTTGTCAACATATCAAGTAGAGTTTTGTTTATAAAGCATATTTGATAATC TAAAGAGTGCAGTATAAATCCTATATTAAAAATAAGATTAAACAGGTTATTATTCCATCCC ATTTACTGGTAGACTTCAGGCAANGGNATGGTCACTCCTTTTGGACTAAATTATAGTTGNG

ATGGGGACTTCATATTTACTGCAGTTTTGCCTAATCTCAATCATTGCATTTCCTTCAATTAA ATTTTΓCTGAAGCTACATTGAGGAATAGCACTCTGCATGGTTTGGTTCTTAAACTGAAGTC CTAAACCAGGAATTTTTTGGGNGGGAACCANGGAAGATNAACCTTGGTGNAAATNAAAG GTTGCTANGGANTTATT(^CTTAAAAAANAAAAAAAAGGCCTTTNTGGGGGCCNACCTNC CAANAACTGGGTNGGGCCATAAGAAAAGGGTTTΓGGGCANTTTTAAACCCTAACCTTGGT

TNAANAAAGACCANTTTCTCCATAAGGCCNGGTTTTTGGNAAATTTTAAAGGATATTTTCT TTTAAAAAAAGCCAANGGTTTTTTTTCCTNAG CTGGGCTTTTATTGGGNAAAAACATGCCTTTTGGAANGNCCCCNGGGGCTTGGGGGCCTTT GAANAACCTGGCCCCNAAAACCCNGGGGGCTGGAAACCCCGGGAACCAAAAGGGTCCCC CTTGC

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGCAAAATCAACACCGATGAGATTATGACCTCACTCAAAT CAGTCAATGGACAAATAGAAAGCCTCATTAGTCCTGATGGTTCCCGTAAAAACCCTGCAC GGAACTGCAGGGACCTGAAATTCTGCCATCCTGAACTCCAGAGTGGAGAATATTGGGTTG ATCCTAACCAAGGTTGCAAATTGGATGCTATTAAAGTCTACTGTAACATGGAAACTGGGG GAAACGTGCATAAGTGCCAGTCCTTTTGACTATCCCACAGAAAAACTGGTGGACAGATTC

TGGTGCTGAGAAGAAACATGTTTGGTTTGGAGAATCCATGGAGGGTGGTTTTCAGTTTAGC TATGGCAATCCTGAACTTCCCGAANACCTNCTNGATGNCCAGCTNGCATTTCTTCGACTTN TNTTCAGNCNGGCCTTTNAAAACATTACATATNACTGNAAGAATAGCATTGCATACATGG ATCATGCCAGNGGGAATGTAAAGAAAGCCTTGAGCTGATGGGGTCAAATGAAGGTGAATT CAAGGCTGAAGGAAATAGCAAATTCACATACNCAGTTCTNGANGATGGGTGCNCAAAAC

ACCCTTGGGGGAAGGGGNNAAAAAAGGNTTTTCCGTNTTNAAAACCCCCANGGGCGGCA NAAATACCTNTTGGGGAANNTTTGGNCCCCCTTTTGAAATTTNGGGGGGCCCTGGAAAAA AAAAATTTGGGGGNGGGCCANTTGGGNCCCTTTTTTTGNTTTTTTTTTNA^ TTTTTTCCAAAGNTCCCCCNAAAAAAGGCTNCCCCCCCCCCNCNTNNNCCCCNTTTTGGGT TTAAAAC GGGC3NrNNCCC<^TNCCAAGGGGGNCC

AAATTTTTTNG

AAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GAATTCGGCACGAGGATTAGGTCTTATAGGACTGGAGGGCAGACAGATGTTTTAATATAC

TCTTTCAGCCCCTGCCACACTCANAGGTGGAGGAGTCACATGTGTCTTATACCGTAATGGG TCCCTGGCACCTGGCACAGACCCAGGGAGCTCATTACATACTTATGGGAATGACTGANTG AAGGAGAGAGACCAGGAAGGAAATAGTTTATATTTTACATTATTAGATTATCACTGANAT GTTTAACCTTTTCACAAATTANATGTTTAGAGTTGCAATCTAGGCATTTTATTCCTACTCAA GCAGCTGAAAGATTAAGGATAATCCTTTTACAGATATATGTTGACACGTCTCTGTGAATAT

GAATTAACTATGTAAATCTTGATTGCCTTTCGTGGGTGCTCAGTTCTCTCTAGAAAAGCAG ACTTANGTGGGCTGCTTCATGAAGCTTTAGGCAGCTTTCTTTTCTCTCTTTTANGACACAGT GAATTACCTTATGCTAAATGTAAATTGGCTTCCTAAANTCTGTTTACTTGCTGNGTCTCCCG GNNNNNNTNTGAAATNNAANNTCNGGGGGGGGNCCGGGNCCCCATTGCCCCNTTTTGGG GGGNClWNANANNNNNNNNNNNGNNNANNCCαWT^^

GGGGGNrWAAAANNANNNTTTTTTNAAANN^ MSTCCCCCNNNNNNN^

NNNNNNCCC

GCCTATNNGGAGNNGNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGGNTGAAGTCCGNTGATTAATGCCAGATGTACAANACAGNGGTTCATATTTGNATGT ACTGGGAGATGATCACAATTANCATTTGTCACCATACACAGAGAAGATTTTCTTGNNATG ACTACTTTNANGATCCACTCTNTNANCAACTTTCATATAAGACATCTGNGTTACAGTAACA

CACTGCCAGGTGGTCACTGACGTGAGGTGTNCCTCATGTAACACCAATCGCCCANCCTNTT ATCAGGTTTACATATTGGCTCTGATGGATGTGANAGCTGGACCATAAAGCTGAGCACCAA ANAATTGATGCTTTTGAACTGTGGTGGAGAAGACTCTTGAGAGTCCCTTANACTGCANGG AGATCANACCAGTCNATCCTAGAGGAAATNAACACTANATATTCATCGGAAGGACTGATG CTGAAGCTGAAGCTCCAGTATTTNGGCCACCTGATATGAAGAGCTGACTCATTGGAAAAN

ACCCTGATGCTGGGAAAGATTGAAGGCAGGAGGAGAAGGGGATGACAGATGATGATATG GCTGGATGGCATCCCGACTGAATGGATAGAAGTTTGAGTAAACTCTTGGGAGATGGACAG GGAAGCCTGGGATGCTGCAATCCATGGGAGTGCAGGGTCAGACACGACTGACAACTGGA CTGACTGGAGATTTGAGANGCCGAATGGGTGAGTTCTGGGGTGAAGCANTAACATCAACC TGTCCCTACTTGAGTTAAGTAGGGTCCTGGCTTTTCCTAAATCAACCCANTGGGTTCCATA

TTGANGGANCCTGNTTAGTGGTGCTTAGTTTTCTGNCAAAGNGCTNTTAGGAACATGCCTT TTTTTTGGGGNGNNAAAANAANAAAAAACNCATTTNTTGTTTTTAAA^ NNTNNNNNTOSINNNNNNNNNTSINNNNNNN^ TGAGNCCNANAGTGNNGTCGTATTACAANGGAGNCCGCTNTANAACTAGTGGATCCCCCG

GGCTGCAGGAATTGGGCCCGAGGCCNCNTTGATAGNCTNCNNGNAGTGCCNAAANGATT

GCGGGCACTNGTCNCANANNGANNNTNNGNAGANTTAGCTGGTGGAATNCGATGAACNG CGTCAGGANNNNGATCTNCTCACNCGNNNNTATCNGGNNTATGAACTCGNNNNAANNNT

NCCTTTATCTTNTTANNANTGCCTGACGNGNNNNNTCNNTTNGATNTACTGO^NNGACCA αSTGNCANANGTNCTNTNCNGATNTrWGGANCNN^^

GNGCNNNNNNAGANANGNNGTGTCTNGGANNNNAGTTCATGAANGANNATNTNANCANT

NTGTNNTCTTTATACTGNNTGTNANATGGNCATTAGTTTTNGTNNAT(^CACACNNANGNC TACANNANNGCGTCNANATNACANNCAAGTNNAGCTGNNNTNTGCTNNANATCNCTNTN

AGANAANTGGCTNTNAACNGNTATNGNNCANTAGANNNCTGNATAATNNGNGNTGGANC

NTTCACNATNCNNTNCTANNNAOWGTN^ INNCNAACNCNGGTNC<^GGAGNNCCATTAN^

GNTANAAOsrANTCTACNCα NTATGGACTNTNGTNCTNNNGTNCGCNNTGTNTNAANNCG CGNGNNCANAGCNNCNTNCTTACANTCNTTNNTGTCNNTCTNAGACNCNGNTTTCCNTAT

GNTNACTNCATNACNTNTNNATTGTNGNNANNGGTNNCCCTNGGNACCNTACNNNCTAAC

NCATTTGNNNNTCANNANGNCCTTCTTT^

CNCANNGTNNATGACGAGGTCTANAGAA(^ACTTTNNGGCCCANNCGTATACCATCACTN

NTNTNNTNGTANTNGGNNANNAANTCNTrø NACTTTTGCACTTNTNCNCACNACGNTNTTC^

TANNNCGTACNOSπsfGANTNACNTTAGANNCNNNTTNNNNNCCG

ANCANGAGGGGGNNGTTNNCCCGNCNCCCCCCCNCNCTNNGCCCTATAGNGAGTCGTATT NCAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGCACNTAGCCTTNGAG

GCNTNTCTNACGNTTGGGCACTNATNCTGNCCCGCTNCGAGGGNNGCCAATTGTTAATGT NACANACTNCTCTCNCAN WTCCCATCCTNCTTTTNNCCCTNCNTNCTCGANCCCrøπ NTC GCNNGTNTNNNGTNNGATCTTTCAGGANNACCACTGGANCNNCNGCNTTCTNNTNNANTT TNNATNCCTNNNAGGGTGGCNNANTSπsf^^ NNATNANTANNNTTGNTNNNCCTCCTN<^A

NNGCGTGTGNGNTNAC(-MSπsπSINANTGNNCNGNGCNTTTTNNTNTGNT^ GACNNGCTCCCTTTACCTNTTTM TNTTTCTNTNGTGNNCTCCTNNNTNN^ TANNNNACANCNNATNNCNTATNTNTNNANCCTTNTCAGGTATTCTACCTNCTTNTCTACT ANCTCCNTCCCCCNG(^TTCTAAATNNTNTGNTC^ NGCNCTGTANNNNNCTTNCTOSINTCTCGNNCTNNTNCNNGNTTNTNNTANANTAATN^

NNCTTTGTTCTCTNTCTNCCGTCNCNNCHNTNCTCCNCCCATTNNTTTTTCCCCCCCCCCNA CCNACTCTCCTTTATCCTCTTTTCNCTGCNCCTANTGTTNAATNGNACCNCCTCTNCTNCCT TCCCCNTGNTNAGTCNNCATCNNCCTNTATT^ CTANCNTATCCCTNNGTCTCNCHNTTCATTNANCNNNNGAATNTCCTCTATTAANNACATN NCGNTCTTO iNNTCCNNANCTCNGACTNGTCTATTNTNGCANCCCNTTNNTCATCTTNTCA

OWNTCNTNCANACTACTNTαsπSfANCAAACTCATTNTCNCCNGCCNTNNTNTCTT^ ANCAGCNNTT JNNCNNGTCATTCGTGCCTTGANANTS[NTCTAGTCTATANCTTTTCTNGTCT CGGTCTTGATT^CTTTCCTrøTTGOT TAGTGTGCGNCTGNNATNATNCTCNTCTTGNGACTNTCHNαstTNTATGTATANNNCN

GGGGGGGGTNCNNTNNCCGNNANTNTNNNTTNT^^

NNTTANNNNATGGNNTGGNANNANTC^ATNTNAGGGNGGNGNNCNNNGNCCNNCCCNTT

TGAAACCNTNGGNCTGCNNACANGGCGGCCGCTCTATAACTAGNGGATCCCCCGNNCTGC AGGGCTGNGNCACGAGNTAATTCCGGTTGAGTGNTGGGTGTGCAGCTGCAGNGGGGACA

NNTGTATNCAAGTGAGNNCTGGATCCAACGNTCNCGAGNTATTGNGNGTCCGTACNCTTA NCCAGA(^AGNCM^CAAGAN(^(^TATTNCNTGNGCTTCANAGGTGCTNCAAGGCCCGN NCGAGCCTGGCTCNTGGCNNTGGGGCAGNTGNNGAAANTTCNGGATNCCCCTATACNGGN TNACTCNGGANGGTGNNGNNNNNATCGGNGTTGCTGAANCTCTCANNCCGAGNGTCCTAC CTTCTNTTANCCTNTAAACCCGCTTCTCNNNGACTTTCTTNTNTNTTTNAN^

GTGNNTTGCCNGGANGNCNNAAATTANGAATTGGTNCAAGGCANGGCCNCCANNCNCAA NNGNAGNNTCNGAGACCGNNCCCCNGNTGGGNCNCCNCNNGNACACAANNNGNGTANCA TGNAAANCCTNNGANAANANNGNTTGAGNNGCCTTGGC(^GGGANACNTCCCTTNNTNC ANTATNANCNNTCTOSINNNANNTT]^Nα^NNNAGNGAAACTGTC^^ GNGGAOSπ^ATNNTGNNACANNNGGNAGGAGNTGNAAGACNNNNTAGNANNNCTTGNNG NANNNCTAAGTNC^GOSINNANCTTGTGNCCTGTNNTNNNANGNT^CCGTNTACT^^ NNGGACGNCNCCGCNCCNNCTNNNTGCGNCNCTNTAGTATNCCTNGGGGCNNGNTGTGCG AGGANTTC(^AANCAANATNNATNGAGANNNTNTTCCANNTNGNTNTTTACCTCNNTAGT NGTNTNTCNTATNACGNNCC<^CGGANTATN^

TCCACCCTGTGGNAC(3NCNT πSfATNNNNNG NCTCCAGNCAATGAGGNATANGGNTTNAT CCCCTTNANANATNTNTGTNTGANGNTNNGTGNCCNCTANNGATANAATGNCTCCTCTAC NNCGATATCNANTNCANNGTNTGTACATNNT(^TNAAGGNACANATATTAGGCGCTTTNT ACCATCTCNNACTANTTANNNGCCACTNGNGCGNNCTNTCTGCGNGCGCTCTCTATNATTG ACTACGCGGNTCNGAGTNGNGNAAATCTCNANCGCTNCANTTACGGTAGNCGGNANANN

GANCGAACNGNTCTNGGTAGGACGCGGGNTTGATGTANNGAAANNTACACAGACNNTTG CGGGGGAANNTNTGNTCGNTCNTNTCNTACNAAACGCTNANNTGGCG

GGGGGGGGTNCNNTNNCCGNNANTNTNlSπSfTTNTNNNNTNNN^

NNTTANNNNATGGNNTGGNANNANTCNATNTNAGGGNGGNGNNCNNNGNCCNNCCCNTT TGAAACCNTNGGNCTGCNNACANGGCGGCCGCTCTATAACTAGNGGATCCCCCGNNCTGC AGGGCTGNGNCACGAGNTAATTCCGGTTGAGTGNTGGGTGTGCAGCTGCAGNGGGGACA NNTGTATNCAAGTGAGNNCTGGATCCAACGNTCNCGAGNTATTGNGNGTCCGTACNCTTA NCCAGACNAGNCNNCAAGANCNCNTATTNCNTGNGCTTCANAGGTGCTNCAAGGCCCGN

NCGAGCCTGGCTCNTGGCNNTGGGGCAGNTGNNGAAANTTCNGGATNCCCCTATACNGGN TNACTCNGGANGGTGNNGNNNNNATCGGNGTTGCTGAANCTCTCANNCCGAGNGTCCTAC CTTCTNTTANCCTNTAAACCCGCTTCTCNNNGACTTTCTTNTNTNTTTNANNCTACCCCTT^ GTGNNTTGCCNGGANGNCNNAAATTANGAATTGGTNCAAGGCANGGCCNCCANNCNCAA NNGNAGNNTCNGAGACCGNNCCCCNGNTGGGNCNCCNCNNGNACACAANNNGNGTANCA

TGNAAANCCITSTNGANAANANNGNTTGAGNNGCCTTGGCCNGGGANACNTCCCTTNNTNC ANTATNANCNNTCTCNNNNANNTTN^

GNGGACNNATNNTGNNACANNNGGNAGGAGNTGNAAGACNNNNTAGNANNNCTTGNNG NANNNCTAAGTN(^G<-MsπsrANCTTGTGNCCTGTNNTNNNANGNTNNCCGTO^ NNGGACGNCNCCGCNCt-KNCTNNNTGCGNCNCTNTAGTATNCCTNGGGGCNNGNTGTGCG

AGGANTTC(^AANCAANATNNATNGAGANNNTNTTCCANNTNGNTNTTTACCTCNNTAGT NGTNTNTCNTATNACGNNCCCNCGGANTATNNTTTGNNAGGTC^TNNNNATCCNAGGNNC TCCACCCTGTGGNACOSrαSfTNNATNNNNNGNNCTCCAGNCAATGAGGNATANGGNTTNAT CCCCTTNANANATNTNTGTNTGANGNTNNGTGNCCNCTANNGATANAATGNCTCCTCTAC NNCGATATCNANTNCANNGTNTGTACATNNTCNTNAAGGNACANATATTAGGCGCTTTNT

ACCATCTCNNACTANTTANNNGCCACTNGNGCGNNCTNTCTGCGNGCGCTCTCTATNATTG ACTACGCGGNTCNGAGTNGNGNAAATCTCNANCGCTNCANTTACGGTAGNCGGNANANN GANCGAACNGNTCTNGGTAGGACGCGGGNTTGATGTANNGAAANNTACACAGACNNTTG CGGGGGAANNTNTGNTCGNTCNTNTCNTACNAAACGCTNANNTGGCG

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGNTGGTGATTCNAAGCNNNTNNNCANCCATAGCNCGGTGNGAACTCAGCGCGACAN ATTCGTGCTGTATATGANACTGGCAGNTCATTGAGGTGGAGAGAACAAGAGCTTGCCCCT ACTTTGCGNCANAATATCNGNTCNNNNTTCTNNNNAACCANNGTNNNNANCNNC

NAATNCAATGTCAGGTNTTAATCCT 1^WCTGAAGGA TACTGNCATCAN TATTTATTACA NTCATGAATCTGAAACGNTATTAAANGAAAAGCCTAATAACNACNCTTCTCTACAACNAN AAATCACCNTNGGCCATAG(^AAAAACCNCACTGTATTTTGNCGGCTGGAATCTTGGTTG GACATTCTCTNANTATTCTGACACCNCGNAATNCCCATTTTTTGNGGANTCTTTNAGAAAN TTATTNTTNNTATGNACACATTCAAGCAGTTGGGNACCTTCCTTCCNCGCACCCTNAACAC

NCACAACNTTCATTCCCTTAGGAAGGCAAGACTTNANGGGAACCCTTTTNTTTAAAAAAA AGNACTAAGGNCTαSfTTTTGNATTACNAGGATTGATNCCTGGCAAAAGTTNCCANCCGTA ACNNNTTTGGNNGTTNNCCCCCCCNCCNCCCCCCCGGNNCCCNNCAANCCΗNGTCCCNTT TAAAGGGGGGGTNAAAANNATTTTNTTTTT TTTTNTGGAAAA^ NATTTTAAGGTTTTTTTTGGNGAAC(_

NGGGGGGGGGTTCCCNGGTTTTTTANNGGACCCCCTTTOT

AAAAAAANAGGAAATTTTGGGAAGTTNCCAAAAANTGGAAGGGNGGAACCCCTTGGNAA GGGGTTTNCCCATTTCTAGGCCCNGGAAAAACNCTAAAACCCCGAAAGGGTNTANANCCN GGGTTNTTTGGTNCCCCCCCT TTGANCACAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGTCGAGGTCGAGCTTCACTGCGGCAGCAGCAGAGCGGAGTGTACATTCTGATTT GCTACGTTTATATATATCTTGAAGCTAAATGTATATATGAGTAGTTTGCCATGAGATAACA

CAGTGTAAACAGTAGACACCCAGAAATTGTGACTTCTGTGTTCTCTCCATTTGAGTATTTT GTAATTTTTTTGAAATATTTGTGGACATAAATAAAAACAAGCTACACTAAACCAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACNAAAAA AAAAAAANAAAAAAAAAAAAANNNNNNNNNTTNGGGGGGGGGGGGNNCCCCCCCCCCC COSπSINTTTTNGGGGGGGGNNNNNNNNNANNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNCCNNNNNN^

CNNNNNNNNJNINNNTSΠSΠ^^

NOVINNNTNNNNNNNNNΓINNNNNNNNN^

N WNNCNCTNTStNNNN( NNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

N]Slr^E^MS[Nr^[NNN^

NNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNTSINNNrø

TTNANCAACAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGTCTNGGNCCANCTTNNCTGCGNCNGCNGNGGANCGGAGTGNACATTCTGA

TTNGCTACNTTTATATATATCNNGAACCTAAANGNATATATNACTGGCTTGCCATGAGAN NACACAGTGTGAANAGNAGACACCCAAAAATTGTGACTCCTGCGCCCTCTCCATTCACTG

TNATGCCANANTNTTGANCTATTTNTGGACCTAAATAAANCNNANCTACTCTTGTAACATG CAAAGAGGTTGGATCGAGTTTAAATGACTGTGCTACCCCTTTTCACATCAAAAGAATGGA CAACTACTGACAACGTAAGGCCGNGCCTGCCTCTCCCGTGGGGGNGGGNCGGCTGCCANG GAAGGAAAAGAACTTGCATGTTGGNGAANGANGAAACTTGGTGGGACCACAGTGAAATT TAAAAGTAAAAAGCTGGGCCCANGNGGTCTGCNGGCTGNAAAAAGCCANTTTAATCAAA

AGNCCCTTTTTTTTTGGTGGTCAAAANGAATTTAA^

CCCTTGCAAATAAAAAAGGTTTTTAAAACCTGGAAAAAAAAAAAAAAAAAAAAAAAAAT TTGGGGGGGGGGGCCCGGGNCCCCCAANTTCCCCTTTTNAAGGGGGGNNNNNNTNTNAA NNNNNNNNNNNNNNNNNNNNNNNNNNN^ ISπSINNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNCM^NNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNCCNNNN^ N N Nϊ ^^

NNC

TTNNNCAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGATTACTTCACATCTGTCTTAGAGAATACTCAGTTACCACC CAAGATTTGTAGCATCAATTAAGTTTTCTAATTGCTCACTGCTCTCCTTAGAACTTATTTGG TTTTAAGGTAGGGAGGAAAAACCTTGCACACTTGAAAAACAAACAGGATAGGACATGATC

CTTGCTCCTAAGTACGGGCTTGAGGAATGTGACAGAGGAGTGCTTCATGTCTTTCGCTGTG GAGAAGTCAGTGGTAGTTTGTTGTATCCCTTGTTTGCCTTATACTGGAGTTAGGTCTAGAA CTGTGCCGTCCAATCATGTGTCTATAGAGGACTTGAAACGTGAGTAGTCTGAATTGAGCCG TGAGGTAAAAGCAGAGAATACACTTCAGATTTCAAAGACTTACTGTGACAAAGAGAACAT AGAATACCTCAATAATAATTTCTTTTATGTTGATTATATGCTGACATAATATTTTGAATAA

ATTGGATTAAATAAAATATATTAAAGTTAAAAAAAATTCCTAAATTCTGTTTACTTGCTGN GNCTACANGNNNNTNTNTGAAACCCTGNTCGGTTNCNGNNNNNNNNNCCCHNTNC NNNGGGGGGCCCNNCCNNNNNNNNNNNNNNNNNNN SiNNCT^^ GGNNTGNGGGGNANNNNAANNANNNNNNNTNNN^ NTNNNNNNNNCCNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNr^NN^ GGGNTTTTTTNANNNNNNNNNNNN GCCTATCTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGTTTTTTTAAAAAATTTTATTTAAATAATGTTT^ TGTTACCCTTATAGGAATGGACAACGCTTCCAAGAGTATGAGCCTTAGATATTTCTCAAGA GTCAAAGCAAAGCAGCTTTTTTAAAAAATAAAAATTGGAAGCACAAGCAAGTGGCACTGG CTTAATGCTGTTAATGTTTCTAGAAGTTTCTACCTTGAGATTATATACCTGATTCATATTAA

AATACCTCTAATTAGCACTGTTTTATAGAGAACCTGACTTAATTGATTATTTTCGGATTTTA CATGGGCCAGTTΓATATGCTGTTATTCACGCTATTAGTTCGTGTAGCCACGTGTTCTTTGTA CCTTTΓGTAGTTTGGTTTTACTGGGTTTACATCTTGATGGTCTAACACTCTAGTTGGTTTCT GGGTGTTTCTCATGGGTTAGCATTTGTATAAAGAATCTGGTCCATGTAAATGCTTTTCATG TTTTTTTCCTCAAATGTTTAAACCACTAG

GTCCACTTGCTCAACATATTGCTTCTAAAACAAACAATAAAGATTCTTTTATTTCTTAAGG

AAAANNNNNNNNNNNNNNNNNNNNR^NNNCCNTTGGGGGGGGGGCCGGGG

CCCNTTTANGGGGGGNNNNNTNANANNNN^^

NNNNNISπsπSlNNNNNNNNNNNNNNNNT^^ NN-\!NNNNNNNNNNNNNNNNNNNNNNNN^

NNNKISπ^MNNNNNNNNNNNNMNNNNN^ NNNNNNNC

TTNAGCGCTNNNNNGNANTCNNNNTNNNAG

TNTGGGCTGAAGGCAATNGCGGNATCAGGGANAO^«^NNNNCCTCTNGTTNNTNAGTTNANT TATGACCAAATGGGCANCCTTATCTNNCATGTCANNATNNCACATNNGNATCAATTNCCA TCGANANATCNATTANCGTNNCACNCANNCCTGGGCATGNGNTTNNTCGAGANCNNNAC GACGNNNCCTTTCTAAOSΠ :GNNTGA(-^TAATGNNANTΓNT(^TAACANNNNCCGANNA^ GACCTATTTGCNGOSΠSINAGCNTCCAGNNGCANTTΓTNTAANTTCTACNTTTCTAACNNAT^

NΓ^ NNCCTCGTTAGNNTTCNCCGCNCTAACNTGNTAAGNCNTNTCGACCAGNNNGNATNA GGGNNNAGC^ANNGGTNTNNTNCTNNANNNNNTATAATTANNNNCCTCTGTNTA TANANTANCGNNCNNAGTTNCCNNNAATC^ NATANATTGTNNCANCCTNNNNAGOSFGCNTNANNCM^JNNNNCTNNTGCCCA NGCANANAANTNAANTCΠSINANCCCNGNNCNATNAACANNANNACANGNNATNTNCNNCA

TGANGNNNNCATNNCGACNATAAATGANNNNNNCTANNGNNTTNCGTNNTTANANCATN NNTATAOSTTACANGCNNTNAGNANNNANTCGGAGTTGNCAGGNNATCTNANACNNNNAC ANGNNNANNTNGTATGACNNNTCNGTCTCNNTAGACNNTANNNCANNTAGGCTCTNNGN ANTCGNTANNAACAANNNGGANTTNTGNANTNTNNNACNATANTANNNNTGANGNANTA CNTNNNTATACCANCCAANNNOSFANTNTGANNNTCTNAGTNNCNNNGATGNTNANTNAA

NGACTNNTAACNTGNTNNNATGATGAGTCNTCGGTCTNNTTACNCNGCCTANANNCNACT NNTNNCNNTCGTGTO ΠSΠSΠSFTNACNCTTGNCNNNTGANATANNANNNCCGACGNAGTATG ACGTTNCATOSINNATACTTGTANACANACNCGANGANCTAGNANTANGTCTTNTNAGTNT NTCTTNACNNNTNNTNCATNAANANTGNTANCGNGNCGCNNNATACGAACTCNNNCTCCT NACNNNTNNTNTATANGNACNNANNNGNTGGCGANGCNANNGTTAGNGTATATCNAAGT

NTNTTNGNGNTNNNGNCNGNNTGGCAGNGNCNCTAGNNGTANGNCTCTTGTCNNTGNAC GCACGNANNTCG

GCCCTATAGNGAGTNGTATTACAGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGAATTCGGCACGAGGCTTGCTTCTCTAGGGAAGAATCCAACCGATGCGTACCTGG AAGCCATGATGAACGAGGCTCCAGGGCCCATCAACTTTACCATGTTCCTCACCATGTTTGG GGAGAAGCTGAACGGCACAGACCCAGAAGACGTCATCAGAAATGCTTTTGCCTGCTTTGA TGAAGAAGCAACTGGCACCATTCAGGAGGATTACCTGAGAGAACTGCTGACCACAATGGG AGACCGGTTTACAGACGAGGAAGTGGACGAGCTGTACAGAGAAGCACCTATTGACAAAA AGGGGAATTTCAATTACATCGAGTTCACTCGAATCCTTAAGCATGGAGCGAAAGACAAAG ATGACTGAAGGAACTTGAGCTAAAACTTTCCAGTTACTTTGTCTTACTCTATACTGNTTCCT ANACATTTCCCCCCACCCCCCATAGGCCTGTTGCATGCAACTTTGATTCACAGCTTTGCCTT TTTTTTTTTTTTGGGNNTTTTTNTTT NCCCNGNAAAGGGGGGNTATANAANTTTTTATTTTT(^TTTGTAAAAANAAAGATT^

TANATTAAAANCCCNNCNTNTTTGNNAACCCCNΓNNNNATTNTTTT AANTTNANTTTNGGGGGGGGCCCCCNC^CCCCCNTATTCCCCCTTTTTNGGGGGGNGCNCT TTNNAANCNNCCNGTNACTCTNTCTNT^ NTTTTNNN1 CTGTCNCNCGTNTNCCNANTTCTTTCTNCCNTNTGCTCNTCTGANTTATAGT CTNATNTTTT(-OTCTTCGCNTC ^

ANTNTNATNCNTNNGNNCG

TTGAGGCCCATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGNAATGGANNGCCNGGNCNGTCTAGNTGNNNTGTGNCTGNCCTCNGNCNGN GGGNNNGGNGGCGNACGNCNTGGCACCCTGGCO^TGNTNTATGCCNNCNTCGCTCANNN OSINNNNTNNCNNNTNATGNTTTTTATAGGAACANTGANTGCTAATGGC^ ACATNGATNNNNCTGGGTNNAGNNANGACGCTC<^ANNN GTNN(^ACCCNNAGACTGANNATTATGGANNATTATNANAACAAAGA>JNNGCACATTNT

CCTTCCTAAAACAATTTCAGATGTCCANTTTGGTGAANTCNANGCGANGCTCAACGNCTC ATNAGCGANANANTCACCTTATTN SfAGACCTACTNTNNGAANGCGAANC^TNNNANTTAT GTANNNGGTNNNNAGTGNAGNCNNNNTTGTANCANOSITAGNTTANTGTANNNGACCTGN NCCNTTCAAGGNGTNATGGNTCGANTTCTGGGNNNCCCTGANNTNNNTCCNCTCNNTNNA TTGGAAACAGCCTTTNTTNTCTGGGNCAAATGNNTNNTAGCCTNATAAGCCCATNCCCTTG

GNCTCTCTTGTTTTTCATNNCTATGTAAACCTTTTNTTTTANNAGATTNT^ CCTTGCCTGNCTNGNTTGGCACTTNCTNTTGTNTGTGGNTTAAAATNTATTTCTCGAGANT ACNTNGTCANTNNNNTGGCCTTNTTANGTNCTNNAANAANNCCTTTTNTTNNTT^ TATNTTNTNNTAANTNTTTNTC(^^^ ATATNNCCACTCATGGACTNNTTTCT^^

ANCATNNATTCNTCTTCTGANCTNGTANNGAAANCGGNGATGNTCNCTNCCTATTACTCTA TNGTTGTTTCTGNNNNCCCCTCNNNGTTTNNCG

TTGAGGCCCATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGNAATGGANNGCCNGGNCNGTCTAGNTGNNNTGTGNCTGNCCTCNGNCNGN GGGNNNGGNGGCGNACGNCNTGGCACCCTGGCCNTGNTNTATGCCNNCNTCGCTCANNN CNNNNNTNNCNNNTNATGNTTTTTATAGGAACANTGANTGCTAATGGCNANTNCATATTG ACATNGATNNNNCTGGGTNNAGNNANGACGTTC(^ANNNTNNTGANNNNGTTGGCATGC GTNNCNACCOSINAGACTGANNATTATGGANNATTATNANAACAAAGANNNGCACATTNT

CCTTCCTAAAACAATTTCAGATGTCCANTTTGGTGAANTCNANGCGANGCTCAACGNCTC ATNAGCGANANANTCACCTTATTNNAGACCTACTNTNNGAANGCGAANCNTNNNANTTAT GTANTWGGTNNNNAGTGNAGNOS1NNNTTGTANCANCNTAGNTTANTGTANNNGACCTGN NCCNTTCAAGGNGTNATGGNTCGANTTCTGGGNNNCCCTGANNTNNNTCCNCTCNNTNNA TTGGAAACAGCCTTTNTTNTCTGGGNCAAATGNNTNNTAGCCTNATAAGCCCATNCCCTTG

GNCTCTCTTGTTTTTCATNNCTATGTAAAC^

CCTTGCCTGNCTNGNTTGGCACTTNCTNTTGTNTGTGGNTTAAAATNTATTTCTCGAGANT ACNTNGTCANTNNNNTGGCCTTNTTANGTNCTNNAANAANNCCTTTTNTT^ ATATNNCCACTCATGGACTISrNTπCTαS^

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGTCGAGGTCGAGCTTCACTGCGGCAGCAGCAGAGCGGAGTGTACATTCTGATTTGCT ACGTTTATATATATCTTGAAGCTAAATGTATATATGAGTAGTTTGCCATGAGATAACACAG TGTAAACAGTAGACACCCAGAAATTGTNACTTCTGTGTTCTCTCCATTTGAGTATTTTGTA ATTTTTTTGAAANATTNGGGGNOSITAAATAAAANCANNCTCCCCTAAACCAAAAAAAAAA AAAAAAAAAAAAAAAAAAAANNNNTNNNTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

ACAAATAAAAANAAAAAAAGAAAAAATNr^NNNNNGGGGGGGGGGGNCCCCCCCCCOSIN CCNCCCNNNNGGGGGGGTNNAAAAANNNNNNNNN^ TNNNNNNNNNNNNNNNNNNANNNNNNNNNAN^ IStNNNNNNNNTNINNNN^ NNNNNNNNTSINNNNTSπsπSINNNNNNNNN^ NNNNN^MNNNNNNNN NNN NNN1^^ MSπNQ QS!NNNT>^^

NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNΗNNNNNNNNNNNNNNNNNNN^ NMSINNNISINNNNNNNNNNNNNNNNNNNNN^

GNANACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGCAC^AGNCGNNCTTCCTTNNGCTGGNAAAGTNCCNTGTNCGNACACTGAGTCCT GCTCTGTGTATNAAGGANACATTGCCTCNGGCTGAATGAAGCAGGGTTTGTGAAAAGTGC TCAGAAACCACAAGTTCCCTGTGCTTTCACAGNTTTTGAGGCTTTTCCTTTTCACACTGGA GACTTTCTTCTGTTΓTNAATGGGGCTACTGTGTGGCTCANAAATGGCTGCTGTGATGAAAA TGCTCATTTGTTAGGAAAAAGAGGTAGCTAI^TTCTCATΓTTGAAAGGACCATGAGCTATT

TAAAAAAAAAAC(^AANANGNGGTTTTATTTACNTGNCAGGGGAN(-^TTNGATCATGTTC ACATGGTTTNAAAANAAANCANTTTTTTTTTCCTNCLTΠ TTTNTTTTTTNTNNTNAAAGNCCCTTNTAGGNAANAAAGGGATGCNTAACCCGAANGGΠ AGGNACCCCCAAGTTATTCCTNGTNAAAGACCCATAATTTTTTGNAACCNGGAANCGGGG AAAACAAAAGTGCCTCCCNAAAATNTAANAAAAGCCCNTTACCTTCGGATTTGGNAAATN

NAAAACCCITCTTTTTAAAAAAAACCCNTTTTTTTTTAAAAAAAAACCGGGGGGGGGCCΠ

CCATNNTTTAAAAACCTTTGAACCCCTGGAAAATTCCTTNTGGCGCGGGGGGCAAAATTTC AAAAAACCTTTTTAAATCCCCAAAATTTT ^ ATTITCNCCCAGGCNNGGGAAAACCCC(^GGGGGTTTINTNNAAAAAAANANGGGNNCC

CCCT

TTGAANACATNTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGTCTGCAACCATGTNTGTTTNNCCCGATATGGCTGANATTGACAAGNTCGNTA

AGNTGAAATTGAAGAAAACGGAAACGCAAGAGAAAAATCCACTGCCTTNGAAAGACACG

ATTGAACAGGANAAGCAAGCAGGCGAGTCGTAATGAAGCGTGCGCCGCCAGTATGCACT

GTACATTCCACANGCATTGCCTTCTTATTTTACTTCTTTTAGCTGTTTAACTTTGTA^

CAAAGAGGTTGGATCGAGITΓAAATGACTGTGCTACCCCTTTTCACATCAAAGAATGGAG AACTACTGACAACGTAGGCCGCGCCTGCCTCTTCCATCTGCTTGTGTGGCTGGCAGGGAAG

GAAAAGAACTTGCATGTTGGTGAAGGAAGAAGCTGGGTGGGACCACAGTNAAATCTAAA

GTAAAAAGCTGGGCCAAGGTGTTCTGCGGGCTGTAAAATGCAATTTAATCAGANTGCCAT

TTTTTTTTGNTGGTCAAAAGANTTTAATT^^

AAAAGTTTTTAAAACCTGAAAAAAAAAAAAAAAAAAAAAANTTTNGGGGGGGGGGCCCN CGGANCCCAATTTCNCCCNNNTAAGGGGGGGGNOSΠSTNTNAAANNNNNNNNNN^

NRVINNNNNNNNNNNAOSΠ^GNNNNNCCCNNNNNCCN^

CTNNNNNNNNNCNTNINNNNNN^

CCNCNNNNNNNNNNNNNNNNTNNNNNNNNNN^

NNNNNNTSΠSINNNNNNNNNNNNNNNNNNN^ NNN MNNNTSΓTNNNN

NACAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGTCTGCNACCATGNCTGACNNNCCNGNTATGGCTGAGATTGAGAAGTTNGATAAGNT GNAATTGAANAAAACGGNAACπsπSfAAGAGAAAAATNCACTGNCTTCGAAAGAAACGANTG

AACAGGAGAAGCAAGCAGGCGAGTCGTAATGAAGCGTGCGCCGCCAGTATGCACTGTAC

ATTCCACAAGCATTGCCTTCTTATTTTACTTCTTTTAGCTGTTNAACTTTGTAAGATGCAA^

GAGGTTGGATCGAGTTTAAATGACTGTGCTACCCCTTTTCACATCAAAGAATGGAGAACT

ACTGACAACGTAGGCCGCGCCTGCCTCTCCCATCTGCTTGTGTGGCTGGCAGGGAAGGAA AAGAACTTGCATGTTGGTGAAGGAGGAAGCTGGGTGGGACGACAGTGAAATCTAGAGTA

AAAAGCTGGTCCAAGGTGTTCTGCGGGCTGTAAAATGCAGTTTAATCAGAGTGCCATTTTT

TTTTGTTGTTCAAATGATTTTAATTATTGG

GTTTTAAAACCTGAAAAAAAAAAAAAAAAAAAAAANGGGGGGGGGGGGCCCGNGNCCC

AANTNNNCCTNAANNNGGGNGGNTTTNNNNTSπSfNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNM

NNNNNGNNNTSfNNNNNNNNGNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNlSπSlNNNNNNNNNNN NAAGCNCCNTTNNNTGTNGGTCNNNNTNGNAAGGGGGNANTACCACTTTTAANAANNTA GGTNGGCAATCCCCCNGNTCTTGCTCTNCTNCTGCNCCCTΑSFACTAGTCTTTTTTTT^

CTTNCTNNGACCCANTTNCCAATNNATTANNGNGGNTCNANTTTΓAANATTNTT^ TCCCTNAANNOSICCGNNCCNTNCTNANCTTCT^

CATGNGAGGATGTAGNANNNGNNNNNANNGAAANNACCNATAAC1TTNCTTNTNCCCGN AGGGNANANTNGTGCTNNNGTNGAATCANCNANNCNGNNANNNNTNAGANNNNNANN^ CNACCCCGANTGCT^JNNGGGNATNAG TΑSINCCNGGGATNCATNNNGNGTCNCGNAANN CTATGGAGNCNNAACNNNNAGANNTANNANNANNCNNNNNNNNCNCOSINGTAAGCGAG NCATGTNNNATTNTCATNGNNTNCTTTAGACTCCAANANNGNNNCCAANACACNATTNAN

NCCTA(^TCNANNANCGNNNATNTNTGTNNGCNNNGNGTNNNNNGNGNGNNATAGGNAT TATACN^JNNNATTNTGNTAG NAC NAGGCTTGTGNNTANNNNNANNNNN GNNTGTTC ATNTNANTCGAANGANANTATNTNGCAGNANGNANTSΠSΠSΠSTGAGTNNNNNGNTNANTGATN ANCC(^GNNCANTATACGGATTNANM> CTATCANANNCNCCNGNNNNTCANGNNNANTN CNGA(^CNGGCNNCAAGNCCCCNGNNNNATTNNCTNAAAANANCNAAGNNTOS[ ^

GANNGGGCGAANANTNNNNGCNNCNAGGTAGNGNNNCTCNNNCNANATTTCAATGTCTG CANNGCCCNNCCNNGNGNACCAGTTGTTCANGANGTGCGNNCNGNCNGCNNTANAANAA NCTNTNCNNNCGTGNTNANTANGTGCAGGNCGNATGGTNNTNNNNNCGCATNTCGGANA NTNGNNGCNAACAGNNTCGCTGNNNNGCN(^CTGGTGANGGAGCAATCNNTCGNNTNAC ATANAS[T INNT^WANAGTANCCAAGAGCNGNNATTGTCTNNNNNGNCAGTANNANNTGC

GTCANNTNNGCNGNGNNNNTNTNCATNCGNTATATGTACNATGCNGAANNNCACCNCNCT NTCANNNCTG(^TCNNGTTTNNNTTATCATAGCNANCGNCCNGCGANACNATCNAAANTA NTGAGTNCNANNNCNAGCNATGNATCNATAACGAGTNTGNNANNAGANTGTNGNANNGC CNNANANCTATCGNGANAGNATANAGTGNTCGNT

TTAANNC^TTANNGGANNNNTTTANNNA

CGGGCTGCAGGATCCNANNNTCCGNACCAGTTNT INNGCTCGAGACATGAGTTNGGACCT

GAGGGCACCGGGATGAOSTNTGNATTTNCTTTGCANNATNAGCCATGAATTTCTNTCCNGG GNATNNTNTNNAGCATGNNGAANNNTNNGTCTAAC^

TGTCNNNATNCrø^GNNCANNNNNCTNNNGNNNNNAANNANTNTCCTAAACTCTNNNT^^ NNNTGTNNTGNAGNNNCNNCGAGGANTTATCAANNTGGNNANCNAGTNTTCATTGNCNN TTTGCNANCNNNACTGNCNGTATNNNAGNNNNANATCCTNNAAATAANNGATCNANNAC CANNCATANTCGTATNTTNNTNA>JNCCTNAC^ ATNTGTNNNNCATATNGNCNACNNNNATCNNNTTNGANCNNNNGATNNTTCAAC^^

CNATTGTNTTACTGAGNNAAGANNNGTTNNACNTNANTNTATNNAGNNAAAGNNN^ GANNN TGTC^WTGTNNTGTNNGTTNAAANNNCTNCTTTNTNANCNCNTCNCTTANGANT CNTANGNTATTATTNCCAA< NTNTTTNCGGNTTCGTANANNTANNATTGGANCATNACTNT TCGTNGTAGANisTNAANATCTACGTANNNAATTNANNTNNNGANCATAAANNCCCCGACC NCACGNANNNNNCNNCCNNGNNNGCANTGTGANCATANAATACTGANTNANCNNNTTAN

TTTNNNNNATAANNCNTNNTGCNANC^^ TNAT>WANTNNNGTGNGlNrNCTNNN^

NCNNATTACCNNCNNAAATCTTNNTCTNATGCNATTAAACNTNTGTGANGTAANNNNTAN CGTGTGCTCCTCNCNANNAGANNNC^ANNNNTAaSINCNATCTANATNAGAGATNAACNN TNTNTACACTNCNTATANTCCTCCTNCNNAGGTAGAACATGANNTNTCCTNGNTACNCAC

CCNATGNNGANTTNGGCCGNNTANCGATCTNANAGCANGNAAGNANTAATAGCATTNAC TNNCGACTNANTANNTAGTCAACNANNCNCCCG

GCCCTATNTGGAGCTNCANCNCNGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGTTCTACCACTGACTCAGGCCCCGATCTTCATCTCCTTCTTCATTGCCTTGAGAGA AATGGCCAACCTTCCCGTGCCCAGCCTGCAGACAGGTGGTCTCTGGNGGTTCCAGGATCTC ACACTATCTGACCCCATCTACGTATTACCTCTGGTGGTCACAGCTACAATGTGGGGTGTCC TTGAGTTANGTGCTGAAACTGGCATGCAAAGTTCTGACCTTCAGTGGATGAGAAATTTTAT CANACTAATGCCCCTGGCAGTCTTGCCCATAACTATCCATTTCCCCACGGCANTGTTNATG

TACTGGCTCTCCTCCAACATGTTTTCCCTGGGCCAGGTGGNCTGTCTCCGTATTCCTGCTGT ACGCACTGGACTGAAAATTCCCCNACGTGTTGTGCACGACCCANACAAGNTANCTCCACN AGAAGGCTTNCTAAAGAGCTTAAAACAAGGCTGGANGAATGCCGAAATGGCCCATCAGC TACAGGAACGGNNAACGACNTATGCAGAAACCACTTGGGAGCNCGCTGCCAGGGGTTCG CTACGACAGACGTTTGCCCACAACNCCTCTGNNGCAGCATTGGAAAGAAATGACCCTCCC

AACACCCCCTAACAGGCAGCAGCANGCAGNGGGCNGNAGTAANCAAAAGNCANAAGTCN

AAAGCAACCCCTGNCGTTGACACCGCTTTGGCTTGAANCCTCTGGTNGCCTTGNTTCACAA

CTNGGGNNAGGGAAACTTCNTTTTTTTTTTTNANAAAACTT^

TNTNCATGGC^GGGGGNTNTTGGCGCCCAGAACCCTTNAAAAAACTGGNGGGGGACATTA

CTTGATGGTTNCATNTTTAAAAAAATGGGANTGCTNOSITACAAGAAANTCTTTCCNCCNTG

GATNGGC

TTNAGCCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTNGNAGGATTGAACGGNCTGCTCACCCCGGCCGAGTGTGGNGTGCTGCTGCANCTGG CCAANGATGCNGNTGAAGCTGGAGCCAGGGCTGGCTATNGGGGTCATCGGTNCCCACACA CCCCCCANGAACGCTTTGAGGGGCTNACNGNGCTNAAGGCCGCACANCTGGCCCGGGCTG GGGCGGTGGGNANTCAGGGTGCCCATCTGCTNTCTGGAGGTNANCAAGCGGGTGCGGAG CCTAACCCAAGGCCTANTTTCCCCCGACCGGGCCCTGCATNTCTCCTTAACCCACCTGNNG

TGCCGGAGCGCCATATAAGGGGAGCAGGCGCACTCGCATGGACCTGAGCCACCCGGTGCA CGCCGACAACTGTGTGCTGGATCCTGACACCGGGGAGTGCTGGCGGGAGCCCCCANNCTA CACCTATNGAGACTACAGTGGACTCCTCTACTCANCGATGACTTCCAANGGCGGGGACCT GTTCTTTCANGGAGCCCAACGCCCTCACAGTAACGGCACAAGTTCNTCCTCGCTGCNGCCG NCTCGTGGCTTCAGCTNAGGCGNGGAANAATNCCCACGGTGTTGTNGNGCCCGTNANNCC

CCGGCCGGGNGCTTGTNCCCCTGGCAACTTNNNGCAAAACCTTGNGNCCCCTTGANCACA AAGGNAGCCANGAAGTNGGATGGGAAGCCCANANNAAATTTGCNTGTNTNGGGCCCCNA AAAAAGGATGAAANGGANNAAAGATTGTNNTCAGCCANGGGAACCCCNNNTNCAAAAAA CCCCCCAACCCGAANGNCTTTC(^TGGGTTTCCAGGAAAAAAGGTTNGGGAAANCCCCCC TNNCNTTTTCAAAAGGAAAATTTTTNAAGGGGGCNTGGCCCCAAAAAACTTTTG

TTTGGCNCNNTTNAATTTGNGGGNGGGG

TTNAGCCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTNGNAGGATTGAACGGNCTGCTCACCCCGGCCGAGTGTGGNGTGCTGCTGCANCTGG

CCAANGATGCNGNTGAAGCTGGAGCCAGGGCTGGCTATNGGGGTCATCGGTNCCCACACA CCCCCCANGAACGCTTTGAGGGGCTNACNGNGCTNAAGGCCGCACANCTGGCCCGGGCTG GGGCGGTGGGNANTCAGGGTGCCCATCTGCTNTCTGGAGGTNANCAAGCGGGTGCGGAG CCTAACCCAAGGCCTANTTTCCCCCGACCGGGCCCTGCATNTCTCCTTAACCCACCTGNNG TGCCGGAGCGCCATATAAGGGGAGCAGGCGCACTCGCATGGACCTGAGCCACCCGGTGCA

CGCCGACAACTGTGTGCTGGATCCTGACACCGGGGAGTGCTGGCGGGAGCCCCCANNCTA CACCTATNGAGACTACAGTGGACTCCTCTACTCANCGATGACTTCCAANGGCGGGGACCT GTTCTTTCANGGAGCCCAACGCCCTCACAGTAACGGCACAAGTTCNTCCTCGCTGCNGCCG NCTCGTGGCTTCAGCTNAGGCGNGGAANAATNCCCACGGTGTTGTNGNGCCCGTNANNCC CCGGCCGGGNGCTTGTNCCCCTGGCAACTTNNNGCAAAACCTTGNGNCCCCTTGANCACA

AAGGNAGCCANGAAGTNGGATGGGAAGCCCANANNAAATTTGCNTGTNTNGGGCCCCNA AAAAAGGATGAAANGGANNAAAGATTGTNNTCAGCCANGGGAACCCCNNNTNCAAAAAA CCCCCCAACCCGAANGNCTTTC(^TGGGTTTCCAGGAAAAAAGGTTNGGGAAANCCCCCC TNNCNTTTTCAAAAGGAAAATTTTTNAAGGGGGCNTGGCCCCAAAAAACTT^ TTTGGCNCNNTTNAATTTGNGGGNGGGG

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCGCCTGCCAAAGCAGGAGACACAGATTCGATCCCTTCATGGGGAAGATCCCC TGGAGAAGGAAATGGCAACCCACTCCAGTATTCTTGTCTGGAGAATCCCATGGACAGAGG

AGCCTGGCGGACTACAGTCCGTGGGGTCACAAGAGTCAGATAGGACTTAACAACTAAACA AAAACAACCTATATTAGAAGGTTGCCACTATTTTTTCCAAGACAGAGCCAGTCACTCGCG GANCAACTTTNGATGTGGCCTGTGTGTCTAACCATTCNTAAATGCCTGATGGCTAACNTGT GAAANCAGAANTTTCCCATTNGTTGGAAAAGCCTTTTGGCNCGGCCTTTCCNATCTTATTA ACCAGGCACCGTTGGTTGGAAAAAGNGAGGNCAGAAGCCAAAAGGGGCTTGTGGTGGAA

AGAATNGAAGCTTNATTTNACGCCCTTCTAACAANCTTTGGGGGAAGGGTTTAAGGGAAC CTTGGNAATATGNAGTGGCAATNGGNAANGGNAATNCCTTGGAATAATTGGGNCCCCCNT TOSTITITTTTCTTCCCCCCCAACCAAAAANACαsriTA TTGGNAAANAGGAGGGNGTCAAAAAATGTAAANCGGGAACCTTCTGGTTTCAAACCNAA AATTTTTCANTTTAANTTTTNATTNGGCCNTTNGNGGAANCCNAAAAATπ

NCCTGGGAATGCTTTTTNCCAGNNNAAAGCHITr^

CCTTAANGGC(^GGGGGGGGGC( NCCCCCCAACCCNTTTTTTTACCCTTGCCCTTTTGGGG

GNAACAGGNAACCAAAAACCCCCCTTANGGGGTTGGNNTTTTTGGTTTTACAAAAACTNG

GGTTGGA

TTNANCAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGCGCCTGCCAAAGCNGGAGACACAGATTCGATCCCTTCATGGGGAAGATCCCCT GGAGAAGGAAATGGCAACCCACTCCAGTATTCTTGTCTGGAGAATCCCATGGACAGAGGA

GCCTGGCGGACTACAGTCCGTGGGGTCACAAGAGTCAGATAGGACTTAACAACTAAACAA AANCAACCTATATTAGAAGGTTGCCACTATTTCTTCCAAGACAGAGCCAGTCACTCGCGG AGCAACTTTTGATGTGGCCTGTGTGTCTCACCACTCCTAGATGCCTGAGTGCTTACATGTG AAAGCAGCAGCTTCCCACTTGCTGGGAGAGCCTTCTGGCACGGCCCTTCCGATCCTACTAA ACAGGGCACGTGGGTGGGAAGAGTGAGGACAGGAGGCAAAAGGGGGCTGGTGTGGNAA GGANTGGAGGCTGATCTCAACGCACTCCTANCAGCCTNTGNGGAAGGGTCTCAAGTGACC CTTGANATAGTGAGTTGCAATGTGAAANGGAAAGCCTTGGGATCATTTGGGCCCCCCTTT NTTTTTTTTCTTCNCCCCCCCCAAATAC^^ GGAAANAAGGNGGNGTTTCCAAAATTGTNANGNGGGGAA<^TCNNTGGTTTNAAAAAAA AAAAATITTNATTTCTTTTTTTNNGGGI^NISINNNGA^

TGGGCCTNGGGATTGTTTTTTCAGGGNNAAAGGNTCT^

CTTCCCTTAAAGGGGGGGGGGGGGGGGGGTTTTANNNAAAACCNTTTTTTTACCCATGGC CTTTTNGGGGGAAANAGGGAAAAAAAAAANCCCCCCCNNGGGGGGTGGNTTTTTTTTNNT TTTCCCAACNG

ANACATNTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGGTTTCCAGGACAGCTGATGGGAGAGGAAGCTGGGTGTCTCCCAAGAGTCCCAGGCT GCAAAGGGGAGAGAGCTGACCCTTCTCAAACCCCTGCTTTGGGCCCAGCCCTGCGCCAGG TGCTTCACAGCTCTTATCTGCCAGATTTTCCCACCTTGTGGCACATGGCGCCCCTAACCAA

CATCCCAAGAGGCCGATCACCTTGCCACATCTGTGCAAGACCTGGGACCACAGGCGTGGA CAGGAAGGGCTCCGAAGCCCTCTTTTTACAGATGAAGATGCCAGGGCCCAGGGAGGATGA GCAGTCTTTGGGGTTACCCAGCCGGAATACTGGGAGACCTGAACCCAGCATTCTGACTCT GCATTCAGTGCTCGCTCCATGATGCAGCGGTCCTAGCCCCCCCCTCAAATGGGTCCCCTCT TCACTGTGTTTCCCAGCATTCCTTGCTCTGACCAAACCGGGGAAGGGACACAGCCCACCCC

CAAAAGATGGAATCATTCTCTTAACCGTCTTTGTCCCAACTGGCTGNCACTCCAAACCCGT CCCCCTGGCCCCTGACCTTGCTGGGTGGGGAAAAGGCTACGTNGGGCCCAGGCTGAACAA TGAATGANCATGTCAAGCTGTCAAAATNTTGGGAAATAAGNGCATTCTACTGGCAACCCG CCTTCCTGATCCCGNCTGGATTTGNACCATAAAGNGACATGAGAAGCCCCCCTGTGTNTGT TTTTGTGTGCCCCCCCCCCCCCGGGGGNNTNCCNTNGNNAGGGGNTTTGGNANNTTTTTTG

GTTTTGGAAAATITGAAAGGGCCCAAAAAAAAAAα^GGGGGGTTTCCTTTTGAAAAA AAAAAAAAAAAAAANTTNGGGGGGGGGGGCCCCN

TTNNACAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGGTTTCCAGGACAGCTGAAGGGAGAGGAAGCTGGGTGTCTCCCAAGAGTCCCAGG CTGCAAAGGGGAGAGAGCTGACCCTTCTCAAACCCCTGCTTTGGGCCCAGCCCTGCGCCA GGTGCTTCACAGCTCTTATCTGCCAGATTTTCCCACCTTGTGGCACATGGCGCCCCTAACC AACATCCCAAGAGGCCGATCACCTTGCCACATCTGTGCAAGACCTGGGACCACAGGCGTG GACAGGAAGGGCTCCGAAGCCCTCTTTTTACAGATGAAGATGCCAGGGCCCAGGGAGGAT

GAGCAGTCTTTGGGGTTACCCAGCCGGAATACTGGGAGACCTGAACCCAGCATTCTGACT CTGCATTCAGTGCTCGCTCCATGATGCAGCGGTCCTAGCCCCCCCCTCAAATGGGTCCCCT CTTCACTGTGTTTCCCAGCATCCTTGCTCTGACCAAACCGGGGAAGGGACACAGCCCACCC CCAAAAGATGGAATCATTCTCTTAACCGTCTTTGTCCCAACTGCCTGCCACTCCAAACCCG TCCCCCTGGCCCCTGACCCTGCTGGGTGGGGAAGANGCTTCACGTGGGCCCANGCTTGAG

CAGTGAATGAACATTGTCAAGCTTGTCAAACTTTTGGGAAAATAANGCATTCTAACTGGG AANCCCGCTTNCCTGATCCGNCTGGATTTTGGNCNTTAAAGGGGACTTGGAAAGCCCCCT GNGGGGGGNANATGGGGGGCCCCCCCCCCCCCGNGGGGAAAACCCCTAAGGANANGGGG TTTTGGGACACCTTTTGGGGTTTGGGGAAAATTTGANAGNGCCCAAAAAAAAACCNGGNG GGTTTTTTTTTTTNAAAAAA

TTNNNCAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGGGCGTCAAGGTTCTCCGTGGAGTTGGAGCTTTGGCCTCCCAGGCCCTGAGGGC CCGGGGTCCAAATGGAGTCTCCGTGGTGCGCTCTATGGCGTCTGGAGGTGGTGTTCCTACT GATGAAGAGCAGGCGACTGGGCTAGAGAGGGAGGTCATGCTGGCTGCTCGCAAGGGACA GGACCCATACAATATACTTGCCCCAAAGGCAACCTCAGGTACCAAGGAGGACCCTAATTT AGTCCCCTCCATCACCAACAAGCGGATAGTGGGCTGCATCTGTGAAGAAGACAACAGTAC

TGTCATCTGGTTCTGGCTGCACAAAGGCGAGGCCCAGCGATGCCCCAGCTGTGGAACCCA TTACAAGCTGGTGCCACACCAGCTGGCCCACTGAGCCACTGCACTAATGCACTCAGAATA TGATGTGGAATTTCTTCTTTCCAGTAAAGACTAGCCATTACATTGGCTTCTCCTCCCATAAN AAAAAAAAAAAAAAAAAAANCCCNNGGGGGGGGNCCNGGCCCAANTTCCCCNTATNGGG NGNNNNNNANANNNNNNISTNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NTSπSlNNNNNNNNNTST SπSlNNNNNNN^ NNNNNNNNNr^NNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNN^ NNTSINNNNNNNISINNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNISINNNNNNNN^

TTNAGCCTATAGTGAGTCGTATTACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGGGCGTCAAGGTTACTCCGTGGAGTTGGAGCTTTGGCCTCCCAGGCCCTGAGG

GCCCGGGGTCCAAATGGAGTCTCCGTGGTGCGCTCTATGGCGTCTGGAGGTGGTGTTCCTA CTGATGAAGAGCAGGCGACTGGGCTAGAGAGGGAGGTCATGCTGGCTGCTCGCAAGGGA CAGGACCCATACAATATACTTGCCCCAAAGGCAACCTCAGGTACCAAGGAGGACCCTAAT TTAGTCCCCTCCATCACCAACAAGCGGATAGTGGGCTGCATCTGTGAAGAAGACAACAGT ACTGTCATCTGGTTCTGGCTGCACAAAGGCGAGGCCCAGCCGATGCCCCAGCTGTGGAAC

CCATTACAAGCTGGTGCCACACCAGCTGGCCCACTGAGCCACTGCACTAATGCACTCAGA ATATGATGTGGAATTTCTTCTTTCCAGTAAAGACTAGCCATTACATTGGCTTCTCCTCCCAT TNNANANAANNNTSINNNNCNNAAAA(^TGNGGGGGGGGCCCGNTSrCCCAATTTCCCCTTNA AGGGGNGNCMNTTACANNNISπsiN^ NTNNNCNNNNNNNNNNTNNNNNNNNNNNN^

NNNNNNCTNTNTTNNNNTNNNNNNNTNNNNNN^ NNNNNCNNNNNNCNNNNNNNNNNNNNNNNOSπSINAN^ NNNNNNNCNNNNNNNNNCNNNNNNNNTNNNN^ NCNNNWTTCTNNCCNNNNTNCN^ NNisπsiNNNCMvπsπsπsπsπsπsfNNNT^

NNNNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTTTTTCTCAAAGAGGGCAGCAGACTGTTCTCCCCACAGGCCATGGGGGGACAGGGC TGGGAGAAGAAATAGACGTGCACCTTATATCATGTAAATATACTGATTTTTCTAGTTCAAG

AAAGAATTATTGGTAGAGTGGGAACGGGAGATAAGAATGAGCAGGAAATCTTGAGTAAG CCAGCTGGCTTTTAAGCCAAAAGGGTTCCTCCGTGTTTATCTTTGAGACAGTCCAACCCCA AGAATAGCTTTAAAAGGGAAATCAGTGCTGAGACGGTGAAGTCCCTTACCCAACACGCGC CCTGTAACTTTAGAATGAACGCAGGCTCCTCAGCTGTGGGCTNGGCATGGNTCCCGTCACC CGTTGGTGTGAAACAAGGCGGGAAATTCATTAGGATGNTTATGGNTTCTTNATCCCACCC

AGCTTTTCCTGGTTCTGGATTCTAAACAACCCANAACCATCTCTTTCCTCCGGTGGCTCTGC TTCTAGACTTGCGTGGGCCCTCAGACCCGTTTCTTGGCTTGGGTTTCCGGAAGCCTTCGGC AGACTTATACACGCATGCTCTTGCTGTCACATTTATTNCTTTGCCCTGCAGCCTTCTTTTGG GGGGGAAAAAAAAGTGCNCTTACTGGACTGTNGC(^TTTTACNGTAGCCCAGTGTNTTTTT CACAGANTGGCCCTATCCCTTTTTTTTTTTTTTTAAAACAGNGCCCCCCTCCCCTC

NTTTTTTNCNTNC^ANGANCTTTTTTTTTT^

CCCCGGGGTTNNGGGGGCCCCTTGGGAATTTTNTTCC(^ATTTNGGCAAATCCCCCCNTGG NNCO^NNGCTCCCTAAAAATTTTNT^^ TTNAGCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCG GGCTNGNNGNATTTCGGCACGAGGCCCGTCTCCTGTGTTAGGTCTGACCTCCGGCCGATCG TCCGCCGCCGCACGGNTTGCCGCCATGGCCCTNANCGATGCCGACGTGCAGAAGCAGATT AAGCACATGATGGCTTTTATTGAACAAGAAGCCAATGAGAAAGCAGAAGAAATTGATGC

NAAGGCAGAAGAAGAGTTCAACATTGAGAAAGGTCGTCTTGTCCAAACCCAAAGACTGA AGATTATGGAATATTATGAGAAGAAAGAAAAGCAGATTGAGCAGCAGAAGAAAATTCAN ATGTCCAATTTGATGAATCAAGCGAGGCTCAAAGTCCTCAGAGCGAGAGATGACCTTATC ACAGACCTACTAAATGAAGCAAAACAGAGACTCAGCAAAGTGGNAAAAGATACAACCAG GTACCAAGTGCTGCTGGATGGACTGGTCCTCCAGGGTTTTGTACCAGTTGCTGGAGCCCCC

GGATGATCGTTCGCTGCAGGAAAACAGGATTTTCCTCTGGTGAAGGCTGCAGTGCAAAAA AGCAATCCCTGTGTCCAAGTTGCAACCCAAAAAGANACGTTTGATGTCCANATTGACCAN GAAGGCCTTACCTTGNCCCGAAGGAAGATANACCGGCCGGTGGTCCGAGAATCTATTAAC CGGGGGACCCGCAAAGAATCAAAGGGTGGTCCCACCNCACCTCGAAAGGTCGGGTTGGA CCTTCATNAGCCCCAACCAAATGAATGCCCCGAANGTGGCGGGGGAGGCC1TTGTTTTGG

TGGCAAATGCCCACCAGGGAAGGTTTTTTGGACTTAACCCACCAGGAAGGTGCCTTGACC AAGGGACCCCTCCCCTTNNTTTGGGAANAAAA(^AAAATGGGCC(^GTNTTAACCTTTCT TTTTTTCTTGTCCCCTTGCCCTTTTTTTTGGGNC

TTNAGCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCG GGCTNGNNGNATTTCGGCACGAGGCCCGTCTCCTGTGTTAGGTCTGACCTCCGGCCGATCG TCCGCCGCCGCACGGNTTGCCGCCATGGCCCTNANCGATGCCGACGTGCAGAAGCAGATT AAGCACATGATGGCTTTTATTGAACAAGAAGCCAATGAGAAAGCAGAAGAAATTGATGC NAAGGCAGAAGAAGAGTTCAACATTGAGAAAGGTCGTCTTGTCCAAACCCAAAGACTGA

AGATTATGGAATATTATGAGAAGAAAGAAAAGCAGATTGAGCAGCAGAAGAAAATTCAN ATGTCCAATTTGATGAATCAAGCGAGGCTCAAAGTCCTCAGAGCGAGAGATGACCTTATC ACAGACCTACTAAATGAAGCAAAACAGAGACTCAGCAAAGTGGNAAAAGATACAACCAG GTACCAAGTGCTGCTGGATGGACTGGTCCTCCAGGGTTTTGTACCAGTTGCTGGAGCCCCC GGATGATCGTTCGCTGCAGGAAAACAGGATTTTCCTCTGGTGAAGGCTGCAGTGCAAAAA

AGCAATCCCTGTGTCCAAGTTGCAACCCAAAAAGANACGTTTGATGTCCANATTGACCAN GAAGGCCTTACCTTGNCCCGAAGGAAGATANACCGGCCGGTGGTCCGAGAATCTATTAAC CGGGGGACCCGCAAAGAATCAAAGGGTGGTCCCACCNCACCTCGAAAGGTCGGGTTGGA CCTTCATNAGCCCCAACCAAATGAATGCCCCGAANGTGGCGGGGGAGGCCTTTGTTTTGG TGGCAAATGCCCACCAGGGAAGGTTTTTTGGACTTAACCCACCAGGAAGGTGCCTTGACC

AAGGGACCCCTCCCCTTNNTTTGGGAANAAAACNAAAATGGGCCCNGTNTTAACCTTTCT TTTTTTCTTGTCCCCTTGCCCTTTTTTTTGGGNC

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGGCCGAGAAGGCAACATGGGTCACCAGCAGCTCTACTG

GAGCCATCCGAGAAAATTCGGCCAGGGTTCTCGCTCTTGCCGGGTCTGCTCCAACCGGCA

CGGTCTGATCCGGAAATACGGCCTCAATATGTGCCGCCAGTGTTTCCGCCAGTATGCGAA

GGACATCGGCTTCNTTAAGTTGGACTAACCAAACTTCCTTANATGGNTCATCCAGCACATC ANCCTTAGGCGGAAACAATNNTAGNTNTTTGT r^ATAAAATAAANGT^^TCAAANCTTCA

AAAAAAAAAAAAAAAAAAAAAAANCCNNNGGGGGGGGGNCCGGGCCCCNANTTCCCNT

NNNNGGGGGGNNTNAAAAAANNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNISπSlNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNN^ NNISINNNNNNNNNNNNNNNNNNNN^

TNNNTNIWTTNNNTNNN^

CCCCCCCCCCCNCOSiNNNNNNNNNNNNNNNNNNNN^

NrxINNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NN]WNNNNNNNNNN!SπS[NNNNGGGGNN^

NNNN TTNANCAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG . CTGCAGGAATTCGGCACGAGGCCCANTCTCATCCCGTCCTCTCCCCTGGTTGTAAATTGCT GCACTGGTAACATCAGGTAACCTAGGAAAGAATCTGCCTGCAATGAAAGAGACTGGGGTT CGATCCCTGGGTGGGGAAGATCCCCTGGAGAAGGAAATGCANCCCATTCCAGTNTTCTTG GAGAAGGAAATGGCANCCCACTCCAGTANTNTTGCCTGGANAATCCCNTGGACAGAGGA

NACTGGCCGGTTGGAATAGGACTGACCACCTACCATTTTCCCACCNTTTCCACTTGGAACT TTCCAGTTTTNGGAAGCAAAAAAATGGACTTCAGGCTTGGTTNGGAAATAACCTACTTTTT TTGNGGGAATNACCTTTTCATTTGNNAAAATAAAAT^^

ACCNNTAAAAGGGTGGAAGNAAAAATTTTCGACCTATGGTTATTAAACTNGATTTGNAAT ATNCCTTGAAAGCTTACCTTGGAAA(^TACCTTATANTTTNCNTGCCCCAAATTTTGTTTGT

TTTAAAATTANAANGGAAAAAATGGATNTAAGTTAATTTAATAAATTAATTGGNCTGGCC TTGGGATTNAATCCTαSfCAGCAATCCTGGTTGGGNCTGGTTTNCCCATTTTGGATNGGGNA ATGGNGGNCCCGGGNAATTTTTTNCTTTTAACCCCTTGAATGCCANGTTAAAAAGGGCTTT CCTNGGGGGGGNCCTTNNGGGGNAAAAAAAACCCCCCCCTTGGCCANNANAACCTTAAA AAAAAAANGGGGGTTTGAANCCCCTGGGGCCCCCAAAAAACCCTTTGGGNAAAAGGNAA

ANGGCAATANCCCCTCCCAAAANATTCNCNCCCNGGGNAAANGNCCCTTGGNAAAAG

GANACATTTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTCGGTCTGGGTGTCANNTGCTCCAAGGAAGTAGCCACTGCCATCCGTGGGGCCA

TCATCCTGGCTAAGTTGTCCATCGTCCCTGTGCGAAGAGGCTACTGGGGGAACAAGATCG GCAAGCCCCACACGGTTCCTTGCAAGGTGACTGGCCGCTGCGGCTCCGTGCTGGTGCGCCT CATCCCTGCCCCCAGAGGCACTGGCATCGTCTCCGCCCCTGTGCCCAAGAAAGCTGCTGAT GATGGGCCGGATTCGACGACTGCTACACTTTTGCCAGGGGCTGCACTGCCACCCTGGGCA ACTTTCGCCAAGGGCACTTTΓGATGCCATTTTCAAGACCTATAGTTACCTTACCCCTGACCT

CTGGAAAGAGACGGTGTTCACCAAGTCTTCATATCAAGAATTCACTGACCATCTTGNGAA

GAACCACACCAGAAGTCTTCGTGCAAAGGACACANGGCCCAGCTGTAGCCACCACATAAT TTTATAAAGGGAATAATTAAGGTGAATGAAACCAAAAAAAAAAAAAAAAAAAAAAAACT TGGGGGGGGGCCCGGGCCCCNATTTCNCTTTATGGGGGGGGNNTSINTNANAAANNT^NNNN NNNNNMSINNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNW

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNlSπsπSINNNNNNNNNNNNN

TNNNNAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGGTCGGTCTGGGTGTCAAGTGCTCCAAGGAAGTAGCCACTGCCATCCGTGGGGC CATCATCCTGGCTAAGTTGTCCATCGTCCCTGTGCGAAGAGGCTACTGGGGGAACAAGAT

CGGCAAGCCCCACACGGTTCCTTGCAAGGTGACTGGCCGCTGCGGCTCCGTGCTGGTGCG CCTCATCCCTGCCCCCAGAGGCACTGGCATCGTCTCCGCCCCTGTGCCCAAGAAGCTGCTG ATGATGGCCGGCATCGACGACTGCTACACTTCTGCCAGGGGCTGCACTGCCACCCTGGGC AACTTCGCCAAGGCCACTTTTGATGCCATTTCCAAGACCTATAGTTACCTCACCCCTGACC TCTGGAAAGAGACGGTGTTCACCAAGTCTCCATATCAGGAATTCACTGACCATCTTGTGAA

GACCCACACCAGAGTCTCCGTGCAGAGGACACAGGCCCCAGCTGTAGCCACCACATAATT TTATAAAGGGAATAATAAAGTGAATGAAACCNNrøWNNANNNNNNNNNNNNAAAACTTG GGGGGGGGCCCGGGNCCCANTTTCCCTTNTANGGNGGGNNNAANNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNISINNNNNNNNNNNNNNNNNNN^

NNNNNNΓ>ΠSΠS[NNNNNN^

NΓ>1NNN I^MIS[NNT^^ TSπSlNNNNNrWNNNNNNN^

TTNNNCANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCTATACATCACTGTTCTTTTGCTGTCTCGTACGCAGCATAGCCTCTTAAAATT GTATCCTGACAAAGACCACATCAGCACATTACCCCGCACTGATCCACTAGATGGCGCTGT CTCAAGCTGGCAGAACACACCAGGTAATTTTTTGACAAGTTCTTTCTGNGTCTCATAAAAT AGAGGTAAAGCTAACATTCTTTACTGATGCGCAGTATCAGATATTTAACCTAAAAATTCAC CAGAGTTATTGTGCGCTGTTGCGTTGCTAGGAAATGTACTACCATTCACCCACATTGCACA CAGCAGGTGTCTCGGAGCTCATTGTGTGCTCACAGAACGTGAAGCGTGGTCCTTGTGGAG TAAATCCACTCGAGAACGAGGCTCTGAGGCTTCTCGGCTGCCTTCCTGACTCCGTCCTGGG ATGAAGACATCCAAATCATTTCTAAATGTTTTTACTCTCACATAAAGTAAGCCATTTCTTG

TTCTGTTCTCTGAGACAGACTTTTCTATCAACTCTGTCCTGTCGTTGCTGCAGTTGAACGAT TITGTTTTGCTTTGATTTGCATTCGAGGGTCCAGCAACGTGCTGTGGGGACGTCCCTGGTG GCCCAGTGGTTACAGAATCCGACTGCCAACGCAGGGGACACAGGTTCAATCeCTGATCCA GGACGATCCCACATGCCGCGGAGCAGCCGAGCCCACGTGCCACTCAGTTGGCCCGTGTGC CACTGGTTGACGCCATGNAAACGAGAAGTCCTGGTACCCCAACNAAGAAGTANCCCCCAC

TTANNAACCAAAGACTTGGNCCAACCCAAAANTNANTTAAAANTCCCNAAAAAAAAAAA AAANCCTNNGGGGGGGGGGCCCGGGCCCCNANTNCCCCCTNNNNNGNNNNNNNNNNNNN NNNNAAANNNNNNNNNNNNNNC

GCCTATNNGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGATCATATAGTAAACCCAAGCCCTTGACCTCTTACAGGAGCTTTGTCTGCCCTCTTAA TAACATCCGGCCTAACCATGTGATTTCACTTTAACTCAATGACCCTGCTAATAATTGGCCT AACAACAAATATACTAACAATATACCAATGATGACGAGATGTTATCCGAGAAAGCACCTT CCAAGGGCACCATACCCCAGCTGTCCAAAAAGGCCTCCGTTATGGAATAATΓCTTTTTATT

ATCTCCGAAGTACTATTCTTTACCGGATTTTTCTGAGCTTTCTACCACTCAAGCCTCGCCCC

CACCCCTGAACTAGGCGGCTGCTGACCCCCAACAGGCATTCACCCACTAAACCCCCTAGA

AGTCCCACTGCTCAACACCTCTGTCCTATTGGCTTCCGGAGTTTCTATTACCTGAGCCCATC

ATAGTTTAATAGAAGGGGACCGAAAGCATATATTACAAGCCCTATTTATCACCATCACATT AGGAGTCTACTTCACACTACTACAAGCCTCAGAATACTATGAAGCACCTTTTACTATCTCC

GACGGAGTTTACGGCTCAACTTTTTTTGTAGCCACAGGCTTCCACGGCCTTCACGTCATCA TTGGGTCCACCTTCTTAATTGNCTGCTTCTTCCGCCAATTAAAANTTCATITTACTTNTAAC CACCNCTTCGGCTTTTGAAGCCCGCTGGCTGATACTGACATTTTNGNAAACGNANNCNGG ACNTTTCCCTTATGGNTCTAT(^ATGGGGGAGNCTCCTNNNNNNNNNNNNNNNN^ NWINNNNNNNNNNNNTSINNNNNNN^

NNrø^NNNNNNNNTTTTTTTTNNNNNNNN^ NNNNNNNNNC

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGGAGAGAGAGAGAACTAGTCTGAGTTTTTTTTTTTTTTTTTGGN GAANTTTTTTTNNGNACCNGCCACCNNGTTNTNGTNAAAGGGGGNANTNGAACCTN^ GGNCCNNCGGCCNGCNANNANTTNGCCCTAAAANGNGCCCCTTTNGNAAANNGGGGGTT TNTWCCNGGNCCNCGNCCCCTTTTTTTTNG^ TTNNTNGTAANCTNGNTTTTAAANNTTNNTTTNNCCCCN

CNNANTTGNC(^AAAACCCTTNCCANGNNGNNTTTTNGTTTCCCAAAAAAAAANTNCCNT TTCCCCCAAAAAAAAAAAAAAAAACCNNGGGGGGGGNCCCGGCCCCCNATTCCCCNTNN NGGGGGGNNTNNNANANNNNNNNNNNNNNNNNNNNNNNN^ NCNNNOSINNCNNNNNNNCNNOS^^

NCNNNANNCNNCNCNCNNTStNNC^^ CCNNNr>[NNNNCNNNNNNC^

NNNCNNNNNNNCCNNNNCNNNNNCNCOSINCNNNNNNN^ NNCMTCMWOvIN NNNC^ NNCTNNNNININNNNNNTNCNNN^^

TTAAGNCCNTNNNGTGNNGTNNNNNTNAAANNGGANNACCGCTCTANAACTAGTGGGAT CCCCCGGGCTGCAGGNCANTGCATATNC TGTTTGGNGTGTGGCAAGTACTTTCANGGCC GGGGNTTGAANTCTCATGCCTACATTCACNGTGTCCAGTTTAGTCACCATGTNTTCCTCAA

CCTCCACANCCTCANGTTTTACTGCCTCCCTGACAACTATNAGATCATTGATTCCTNANTA GANGACATTACGTATGTGTTGAANCCCNCTTTCACAAAGCAGCAGATTGCTAACTTGGAC AAGCNCGCCNAGTTATNCCGGGCATATGATGGCACCACTTACCTGCCAGGTATCGTNGGC CNGAATAACATNNANGCCAATTGACNACTCCAACTGCCGNCCTTTCANGCTCTGTCTAAC CNTTNCTCCTNTCTGGANCTACCTTCTGGCAAGANGACNACTNTATANGAACATCNNATNT CTNCANGGGGATATTATCGATTTTNNTNGGTCCCANNNGTTNNCGNANNAGCTNCNGGAG AAAACTTTCTNNTAACCNCTTGCCAATTNCNAAAGCA(^TGTCCTCCTTCCCCATTGAAAC CCTCCACNCCTNTC jTCCTCTNGNCCACCrø^^ GGGGGGGAT⁽_^GAAGGNGNATTTΓTACTNNCCCTGGGGCTTTTNGAANGGNTNANNCANT

NCACCAATTGNNNGGGCCTCANNNGAAGAAANANCNANNANCTNTTNGGTNCCTGANNG

GTTANTNCC3SFGAGGGNNNCNNNGNAGGCTNNNTTNNTTNANAAAANTNNGCCT^ GNTTTNTTNNTCGNNANACATTAAAAGAACATCCCTNNNGNTCTNNANTGNANCANTTCC NCNCGGATNNCANNNOWCGNTTN CCCTAAATATTNATTGTCTAGAGCNANNTNGGANC CCTTTCNTACCCTGTNCTCCNAGNTCCTATGGGNATNCTAAATGTGCNANANGTTNNNTAN

TATCCNNCCCGNCC

TTAAGNC(^TNNNGTGNNGTNNNNNTNAAANNGGANNACCGCTCTANAACTAGTGGGAT CCCCCGGGCTGCAGGNCANTGCATATN(^TGTTTGGNGTGTGGCAAGTACTTTCANGGCC

GGGGNTTGAANTCTCATGCCTACATTCAαSfGTGTCCAGTTTAGTCACCATGTNTTCCTCAA CCTCCACANCCTCANGTTTTACTGCCTCCCTGACAACTATNAGATCATTGATTCCTNANTA GANGACATTACGTATGTGTTGAANCCCNCTTTCACAAAGCAGCAGATTGCTAACTTGGAC AAGCNCGCCNAGTTATNCCGGGCATATGATGGCACCACTTACCTGCCAGGTATCGTNGGC CNGAATAACATNNANGCCAATTGACNACTCCAACTGCCGNCCTTTCANGCTCTGTCTAAC

CNTTNCTCCTNTCTGGANCTACCTTCTGGCAAGANGACNACTNTATANGAACATCNNATNT CTNCANGGGGATATTATCGATTTTNNTNGGTCCCANNNGTTNNCGNANNAGCTNCNGGAG AAAACTTTCTNNTAACCNCTTGCCAATTNCNAAAGCACNTGTCCTCCTTCCCCATTGAAAC CCTCCACNCCTNT(^GTCCTCTNGNCCACCCNTCNαWCTTTTTANCAATNNACNNATACA GGGGGGGATCNGAAGGNGNATTTTTACTNNCCCTGGGGCTTTTNGAANGGNTNANNCANT

NCACCAATTGNNNGGGCCTCANNNGAAGAAANANCNANNANCTNTTNGGTNCCTGANNG GTTANTNC(^GAGGGNNNCNNNGNAGGCTNNNTTNNTTNANAAAANTNNGCCTANTTCTG GNTTTNTTNNTCGNNANACATTAAAAGAACATCCCT JNNGNTCT WANTGNANCANTTCC NCNCGGATNNCANNNOπsrCGNTTNNCCCTAAATATTNATTGTCTAGAGCNANNTNGGANC CCTTTCNTACCCTGTNCTCCNAGNTCCTATGGGNATNCTAAATGTGCNANANGTTNNNTAN

TATCCNNCCCGNCC

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCCGGTTTCCTGAGNCCCGCAAGGCGGCGGAGACATCTCTTTTGAGTAAACGA

CTCAGCGTCCAGTGCTCCAGTGGAAAGATCTAAGGGGCCCGCCACTAGCGCCGCCACCAT GCCCAACTTCTCTGGTAACTGGAAAATCATCCGATCGGAGAACTTCGAGGATTTGCTNAA AGTGCTGGGGGTGAATGTGATGCTGAGGAANATNGCATTGGCTGCANCATCCAANCCANC AGTGNANATCAAACAGGAGGGGGACACTTTCTACATCAAAACCTCCACCACCGTGCGTAC CACAGAGATCAACTTCAAGATCGGAGAGGAGTTTGAAGAGCAGACTGTGGATGGGAGAC

CCTGTAAGAGCCTGGTGAAATGGGAGAGCGAGAACAAAATGGTCTGTGAGCANAGGCTG TTGAAGGGAGAGGGTCCCAAGACCTCCTGGACCAGAGAACTGACCAACGATGGAGAGCT GATCCTGACCATGACGGCGGATGACATCGTGTGCCCCCAGGGTCTACATCCGGGAGTAAG CGGCTGCGGCCCCAGAGCCACCAAAGCTTGCCCCCCGNCCATGCTTCCTTGCTTCCTGNCC CACCCCTTTCTTTTAGGCTAGCTTTTNCCCTTATTCCCAATCACTTTNTGGGGGGTTCTGGG

GTTGCCTTTNTGCANGGGCTTTT(_^TTTTATTGGACCCCTTαSfT^

AACCCGATGGGATGGGAGCCCCAAAATCACCCGATTCCANGGATTAATTTCCCCCGAACC CCCCNCCCTGGGGCCTTANCCCCCAAAANAANCCCCGNANNAACCN^ TTTTGNAAGGGGGANCCCCAGGGGCCTTAAATNNGGAAAAAAACGGGCCCCTTTGGGCTT TCCANTTTTTTTG

TTNANCAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCCGCCGGCCTTGGGGCACTGTGCTGGTCGGCGGAGTAGGCGGCCATGGGGAG CCTCCGCGGCCTGCGCCTGGTGGCTGGAAGTTGTTTTAGGTCATGTGAAAGAGACGCTTTC

TCATCTTTAAGGCTTACCAGAANCTCTGATTTGAAGAGAACAAATGGATTTTGCAGCAAA CCCCAGGAAAGTCCAAAGCCTCCAGACCAACACACTTACAGCCACAGAGTGCCATTGCAT AAGCCTACGGATTGGGAGAAGAAGATTCTAATATGGTCAGGTCGCTTCAAAAAGGAAGAT GAAATTCCAGAGACTGTCTCGTTTGANATGCTCGATGCTGCAAAGAACAAGGTCCGGGTG AAGATCAGCTNTGTAATGATTGCCTTTGCCAGGGGCAGGATGCGTATTGATGGTTATAGA GGGCAAGAAGGCTGCCANAANAAATGANACTTTACCAAGCTTGAACCTAAAAAAAAAGC TTGTNTGAAAAAAAAANCTTGTTTTGAAGGCCAAACCGAGTACCANATNTNTCGTNGGTN GGATTTTGAANACCTAAAAATAATGCTGCAGCAATAGGCCTTATTAAAAANAANGGGGGG GTTGANCTTNCCTTNTTNCCCTTTTAAACTTCNAATAAATTITNΠ

AAAAAAACCTTGNGGGGGGGGCCCGGGNCCCCAATTCCCCCTTΓANGGGNGGNMSΓNNNA

AAANNNNNNNNNNNNNTWNNN

NNTSΠSINNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNN^

TTNANAAAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGCGCTTCTTTGCTCGCTCCTCCGCACCCCGCGGCCCGTC

TCCTCCATCGATCGCCATGGAAGAAGAAATTGCCGCCCTCGTCATCGACAATGGTTCTGGC ATGTGCAAAGCTGGCTTTGCTGGGGATGACGCCCCCCGGGCCGTGTTCCCGTCCATCGTTG

GGCGTCCCCGACACCAGGGCGTCATGGTGGGCATGGGGCAGAAGGACAGCTACGTGGGC GACGAGGCCCANAGCAAGCGTGGCATCCTGACCCTTAAGTACCCCATCGAGCACGGNATT CGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTTTACAACGAGCTGCG TGTGGCCCCCGAAGAACACCCCGTGCTGCTGACNGANGCCCCTTCTAACCCCAAGGCCAA CCGTGAAAAGATGANCCAGATCATTGTTCGAGAACGTTCAACACTCCTGGCATGTATGTG

GGCATTCCAAGAATGGGNAATANTTAGNCGACTGATGCCCGAACAATTGGGAATTGTCNT TGGACTTNTGGGGGACGGGGNNCACCCCACACCGGTGCCCCATTTTACGAGGGGGTACGC

CCTNNATSΠSINNNNNNNNATNCTTGCGTTTTGGACCTTGGCTTGGCCGGGAACCTGGACAGA

ATTACCTTAATGAAAAATCCTTAACNGGAACGNGGGTTACAGGGTTTTAACCACCCACAA GCCCGANCCGGGGAAAATTGGGGCCGNGGACATCAANGGANAAAACTTTTTGGTTACCTT

NGCCCCTTGGAACTTTCGAAACAAGGAAAAAGGGTTAACCGGGTGNAATCCCCCCTTCCT TCCTTTGGANAAAAAAACTNTTAANCTTGNCCCCCAANGGTCAAGGNGAAAAACCCNTTG GGCAATTGAACCNGGGGTTCCGGNGGNCCCCANGGGACCTTTTTTC /

TNNNNCAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCTTTTGTATTATCAAGTAAGATTCTTTTTTCGGCTGTATA TAAGCAAGATΓGTTTGGTTTATTCTTTTCTTTTTTAGCGTAGGAAAAGTTTGTTGTTA^ ATGCTTCAAAATTATTGTTAATTGTATTTTGAATTTACATCTAAGCCTTGTAAATCATAACT

TTTCAAATANCATNTTNTGAGTCATANCCAGCCTGGCAATCTGATGGCCTAAATGGANAG GGGANCAGCTCCTTGGNGAATGATAAGTAANGGCANAAAANATTGTNTTTCATNCCTACN

TTGGGGAAAAAAGCNTANCCCTGANATTTTNTTCTGATNAACACATTGNCTGCNCATGCA AAAAAAAAAAAAAAAAAACNTSfGGGGGGGGGCCCGGCCCCAATTNCCCCTTANNNNNNNN NNNTNAAANNΓ^NNNNNNNNNNNNNNNN^

NNNNNMSINNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNr^^

NNNNNNNNNNNNNNNNNNNNTSπSiN^

NNNNNNNNNNNNNNNNNNNNTSπsπSIN^

ACAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAAATTCGGCACGAGGAGACATGGCCAAGTCCAAGAACCACACCACGCACAACCAG

TCCCGAAAATGGCATAGAAACGGCATCAAGAAACCCCGATCACAACGATATGAATCTCTT AAGGGGGTAGACCCCAAGTTCCTGAGGAACATGCGCTTTGCCAAGAAGCACAACAAGAA GGGCCTGAAGAAGATGCAGGCCAACAATGCCAAGGCCATGAGTGCACGTGCTGAGGCTG TCAAGGCCCTCGTGAAGCCCAAGGAGATCAAGCCCAAGATGCCAACAGGTGGCAGCCGC AAGCTCAGCCGACTTGCCTACATCGCTCACCCCAAGCTGGGGAAGCGCGCTCGTGCTCGC

ATCGCCAAGGGCCTCAGGCTCTGCCGGCCAAAGTCCCAGGCCAAGGCTTCACCCAAGGCC AAGCCACCTGCGGCTGCGGCTCCAGCTGCCAAGGGTGCCCAGGCCCCCACCAAAGCTCCG GAGTAGAGACCTTCATCTGCCAGTGTGAGGACAGAAGGACTGGTGTGACCCCCTGGGCTG CTGTCTGCGTGGGGCTGGTGTCCTCCTGTGCTATTTGTACAAATAAATCTGAGACAGGAAA AAAAAAAAAAAAAAAACTNNGGGGGGGGCCCGGNNCCCATTTNNCCCTAAANGGGANGN

NNNNNNNNAGNNNNNNNNNNNNNNNNNNNNN^ NNNGNGNNNNNNr>πS[NNNNN

NTSΠNINNNNNTSΠSΠ^

NNNNNNNNNNNNNNNNNNNTSπSQSπSfN^

NNNNNNNNNNNN^

NNCAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGCTTTGGGGTTCTTTCTCCGCGTAACGTGTGGTCTCTGATATT

CAACCCTCCTCCCAGCATAGGCTGCATGAGGCGGGGGCGGGCTCCCACATTCCTGCTCGG CGGAGGGGCCGCTCTGCTGCTGTCGCTGTTTTGGATGCCGACACTGCTGCCTGCAGCCTCT CGCCTTCTGTTGCTACCCCGAGCCCTGCTGTCCATGGCTTCAGGAAGTCCCCCGGCCCAGC CCTCGTCGGCCTCGGGCTCCGCCTATGTCCCCGGCTCGGTCTCTGCGGCCTTTGTCACCTGC CCCAACGAGAAGGTCGCCAAGGAGATCGCCAGGGCTGTGGTGGAGAAGCGCCTAGCAGC

CTGCGTCAACCTTGTCCCTCAGATTACATCCATCTATGAGTGGAAAGGAAAGATTGAAGA GGACAGTGAAGTGCTGATGATGATCAAAACCCAAAGTTCCTTGGTTCCAGCTCTGACGGA TTTTGTTCGGTCTGTGCACCCTTATGAAGTGGCTGAGGTGATTGCATTGCCTGTGGAGCAA GGGAACTCCCCGTACCTGCAGTGGGTGCGCCANGTTACANAATCNGGTNCTGACTCCAGT ACAAGCCCCGCTGTGAATGAACCTTTGGTCNTGGCCTGGGTTNCCTCATAAATATCAACAC

TTCTACCCπGGAAGAACNGGACTCπAAAAAAATCCCGGπ NNNNNNNNNNNNNNNNNNNNNNNNNNNGGGGGGGGGGGGCCCNNCCCCCN^ TTTNISINNNI INNNNNN NNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNN

TTNNTNTAGTNANGNNTGCTNGANCNCACNGNNNCCTNTNAGNCCTATATGGAGCTGCAT NACAGTGGCGGCCGCTCTACAACTAGNGGATNCCCCCGGNCTGCNNGAATACGGGNTCCN

GATCTNAGGNNTCNCTTNAGATATNNTNTGTTNNCTNCNAGTNGTCCTGTNGATCCCNTTA CCNTNTGNNATNNTNTCATTCNNGNCAANTGNAAGNAAGGTANGTCNCCCTCAATGTANT

ATTNNGTNTNCGNTNGCNGTCTTNNN^ CTGNATTNATTNNTTTNTATNTTCTCCC^^ NNAAC(_NCC<^TTAGCTCNTANNNNNTANNT^

CNNCANNTANNNATCTA(^GANNTAATNTTNTTAANGTNTTTNNCTCCNGTNTCCCCNNN TO^NNTNTANCNNNTNTCNTTT^^

CNCCTNNTCCNNCCCNNTTNNNNTTCCCGNCATATTNTCTTTAANGTANACTNTNCNATAN CTGTTNTNTACTTNTTANGNTNNACCACATCTTNCTGTAAATNCCNACCTTTCNCCATNNA NNCNNACANCGANTTANNNTTTTTNTNTNNCTTTT^

TATCCTCNCTNNCNATNNNTCTNTCNNNNCCCTTNTTNNTTTCCT^^ CCNNNTCNATGT(-KNACTCTGTATTTTATNNCCTTAAGACNNTCANCANTNGNATNTTT^ TNNATTTNATTACTATCGCNNNNNNCCCNGNGC^^ NTTNAT(^ANNNANCTATCTCTGNAANNTCNGCTTCNNTNCATTNNAANTNTNGCCANCN ATTNNGTGTAATNTNTNTATTNTCACNTNNTNTNAATNTTNTNCTCCTNTANGANNN

ATATCNNACNNTNNTGNTCNGCTCNTCAC^TTNTATNTATCNTNTATATAGNTNNTATATN GATTGTTCTNTNANGATATGCATANNTNTGNTCATCTGTTATTGCACCTCGCNANACTNNT NNGTNANCTGNCTATNTGCNCATCTATCTCCTTAAGNTCNACANCNCTTNNNGCGNCNCT GATNCTATNTATNTCTCNTCNTTANCATACATNCTNCTCCTNNTCNCCG

TTNAGCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCNG GCTNGNNGGNNANGGGCATATGCTTGGTCTGGGTGGTGTGGNAAGGACCTTTNAGGGCCG GGGTTGNAAGNTTANGNCTNNNTTTAOWGGGNCNANTTAANCNNC^TGG CNTCANNCCCITAAGNTTTANNGGCHΓCCTNN(^ACNANNAAAACATTGNTTCCTNACTN

AANGANNTTACGTATGNGGTGAANCCCACTTTNACAAAGCANCAGATATGCTAACTTGGA

CAAGCAAGCCAAGTTATCCCGGGCATATGATGGCACCACTTACCTGCCANGTNTCTGTGG

GCCTGAATAACATANAGGCCANTGANTACGCCAACGCCGNNCTTNNGGCTCTGTNTAANG

NNCCTCCTCTCNGGAACTACTTTCTGGNAGAAGACACTTATANGAACATCAAACGNCCTC CAGGGGATATCATGTGCTTGTTGGCCANCGTTTCGGAGAGCTGATGAGAAAACTCTGGAA CCCTCTAATTTCAAAGNACATGTTTTCCNCATGAAANGNTGCAGGCTGTTGTCCTCTGCNG CAAGAAGACTTTTTNTATCACGAAACAAGGGGATGGAGNTGATTTNTCTGNCCTGNTTNTT GAAAAGCTNTACACTNNANCTCTGGGGGGGNGCCCCNAAGNAAAAAAAAAAGACAAATT GTTACCTGGACGTTTTTCCANGGGGGNGCCATTGAAGGATCTTTCNCTAAAAAAAANNGC

CTTCATCCTTGATTTTGGCCANCAAAAAAAAAAAAAAAANC^

CGANTNNCCCCGGNNAAC(^ANGGGNNGGGGGGNCNCNANTTAATTTACCNTGGCCNCT TGGNANGTTTCCTTTNCCTCCCCCCCTGTTNCNNGGGACGGAAAAANGGANACNGGNTTC ATTTTITCCCCNNNGGGGNTTN

TTNAGCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCNG

GCTNGNNGGNNANGGGCATATGCTTGGTCTGGGTGGTGTGGNAAGGACCTTTNAGGGCCG

GGGTTGNAAGNTTANGNCTNNNTTTAαSINGGGNCNANTTAANCNNCNTGGNTTTCTTAAC CNTCANNCCCTTAAGNTTTANNGGCNTCCTNNCNACNANNAAAACATTGNTTCCTNACTN

AANGANNTTACGTATGNGGTGAANCCCACTTTNACAAAGCANCAGATATGCTAACTTGGA CAAGCAAGCCAAGTTATCCCGGGCATATGATGGCACCACTTACCTGCCANGTNTCTGTGG GCCTGAATAACATANAGGCCANTGANTACGCCAACGCCGNNCTTNNGGCTCTGTNTAANG NNCCTCCTCTCNGGAACTACTTTCTGGNAGAAGACACTTATANGAACATCAAACGNCCTC CAGGGGATATCATGTGCTTGTTGGCCANCGTTTCGGAGAGCTGATGAGAAAACTCTGGAA

CCCTCTAATTTCAAAGNACATGTTTTCCNCATGAAANGNTGCAGGCTGTTGTCCTCTGCNG CAAGAAGACTTTTTNTATCACGAAACAAGGGGATGGAGNTGATTTNTCTGNCCTGNTTNTT GAAAAGCTNTACACTNNANCTCTGGGGGGGNGCCCCNAAGNAAAAAAAAAAGACAAATT GTTACCTGGACGTTTTTCCANGGGGGNGCCATTGAAGGATCTTTCNCTAAAAAAAANNGC CTTCATCCTTGATTTTGGCCANCAAAAAAAAAAAAAAAANCAACNTCNTGCNTTATTTAC

CGANTNNCCCCGGNNAACCNANGGGNNGGGGGGNCNCNANTTAATTTACCNTGGCCNCT TGGNANGTTTCCTTTNCCTCCCCCCCTGTTNCNNGGGACGGAAAAANGGANACNGGNTTC ATTTTTTCCCCNNNGGGGNTTN

TTNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCAAAAAGCGATTGCAGTTGTTGATGGGGACCGAGATA AGGCCCAGAATTCTGACCAGATACTTGACACTTCATCACCCGTTCCTGGCTGTTCCTCTGT AGCTAACATCACATCATCTCAGACAACCTCACGACAACAGGGACTGGCACATCCAACTCG AGGAGGTGATGCTGAGGCTGAACACACAGTGAGCGAGCACCCAACTTCTAGCAGCGGAG

CCCCAGCGCCTTCCTCATCTCAAGCTAGTGAGGGTCTCCCTCAGCATTGTGCCTTAGGTCA AGTGGAGGATCATCCTTGGCAGCTCANACAACCTTGTTANTTGATAGAATACCAAAGGAT ACAATTGNCGGATCCGACTGAACACCACTTAAAAAGGAANCCGAATCCTGANAACTTGGC CCGNCTNTNGAGTGGGNCCGAAAAAAAANCTTANTACATNGNAANGCTTGGAATGGCNN CCCAAAΛTTCCCTTGCCCCGGCCCATTAATTTTNAAANCCATGNGNTTACCTTTNCAGGNC

CCCGGGAATCATTCGAGGGGCTTGNCAAAAGGAAAAGGGTCTTCCCATNTTCTTNAAAGG AAAAGGGGGCNCAAGGANCAGGAAACATTTTTGATGNATTTACAAGGGGNCCCGGNTTTT GGCCGGTTGGACCAACTTGCCAACCCAAGTTGNTTTTCATTANAAGGAATCGCTTGGGCC NTTTNAAAAAACCGCCNAAAANCCCAAGTTTTITANGGGGAATCCAAGNCCCAAGCTπ CAAANAAAAAAAACTTTTCTTTNAAANAATTAAATNTTTAAAAANGGCCGAACCTTT^

TNCCANAAAGGGGGGGTNNTTTCANGGGAAAAANCCCNAAAAAATTAAGGGGATTNAAA AAANAAATTAATCCAANCCCCIWCCrø^GGGATGNAAATTTTNG ^•

TTGANAAAGCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGCTTNNNNACNCCNTCGAACTCNANGGGNNNCCNGGGNCCC AATTCGCCTATAGAGGANTCGNNTTACANTCCTGAAGGNNNCCNNAANANCCCTNTNNGA AATTNCATGCNCCNGNNATNNCNCCNTCCTNANCTNCNGAATGAANAANNTGGNCTTGAT CCTNNαSlAAGNTGGCAATNCGNATNCTATNAAGTCCTTTNNNACCGTGGAANTNGGCCAA ACGTGCNTAAANNCCATTCTTTTGNTTATCCCNCAGGATTACTGGTNACCATTTCCTGNCG

ANGAGAACANNOSrTNTTGGGTTTGNAGACTNC^^

TGCCTATCCTGAACTTGCCGAAGACGGACCTGGNTNCCCTGGTTGNCNTTCCNCCTGGGTT TNCTNCAGCt^GGGCCTTNTCAAAAAAATTACATTTTCNCTGNGNAGNATTNCCATTGGC ATACATTGGNTTATTGCAGNGGGGAATNTAAANAAAAGCCTTGAAACTTAATGGGGTCAA ATGAAAAGTGAAATTTC^ANGGNTTGAANGGAAAAAAACCAAATTTNCCATTCCCNAGTT

TTGGNNGGAATGGGTTGNACCAAAAAANACCCCTTGGGGGGAAATGGGGGCCAAAAACA

GNNTTTN(^TTATTTAAAACCCCCCAAGGGCCGGNAANACCTNCCTTANTTNGGANAATA

TTNGCCCCCCTTNTGGANNTTCGGGNGGGGNCNTTGAATNAAANAAATTTGGGCNGAAAN

CTTTGGGCCCCCGGTTTGGCCTTTTTN^

AAAAAAAAACCTTTNCACCTCCCAAATTNNCCCTTTTGGGGNTTAAAANTTTGGCGNG

CCGTCNANANGGG(^CCANGTTCCCCCGTTTTITTNTTTTCCCNAATTNTN^

TNNANNANAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGNTTGTATGTACAGGGCANTGATGTAACAACAAAAAATACCTGAGAAACAN AATGTCCATGCTTTCTGCATCTTTAACACTTTGTGTTTGTATCACCTCATGGTGGCTTATTT TTCCTGTTGTACCATCCAGTCAGATTTTGAATAAACGAGTTTTGAAAAGACAGTACCTTTT ACTATAATTGCCATTAGCAAAGTAGCCCTGGGTACTTCATGAGAACCGGTATTAAAATATT AGTGGGACGGCTCTTTTCTGAAGCTTCGGAAGTANCCACATCAGGGACCTAGGATATTTTT

CTGAGGTCACTGGACAACTAGACTATGNATTGGCTGCTATNCCCTGACCTGTANTACAGA ATGATGCCTTGGCTATGTAATGGAATATATTCTAAGGGGGATGGTGTATATTAAGGGACTT TNATTCACAAGTACCATANTGGATATTCCAATGTATGGNAAAAACCATCTGGTGGGTTGG GGNCANTTTTTAATTTACAGGTTTGNATTAGAACCATAANATGAAAACCTCTGGGGAAAA AANTTTTGAATGGGCAGCCCCACCCCCAAACTATTTTTTAAATCANTTCATTANAANATTT

TCTTCAATAAGGGNCTTTAATTTTTCCTTTTGAAACCTATAAAATACCGTCAANAAAAAAA AAAATCAAGTTATCTTTNTTTCTATCAACTGGTTTTGGACCTAGTTTTAAATATAAAANGG NCCT ANATTTGNAANACCTTTTCTTTTGCCTTACACTGGCCTCANTTATAAAAACAGGGC ANTTTCNCGCTGGTTCANGGGGATCACAAGGGACCTCAACTGGAAANTNAAAANTTTTGG TATCNAANAAATGTCCGNCATNGGCAATGGTNCCNCCCCCCCAATTAAAAATACCTTTTCC

AAGCTTGGGATNCCCC^AAAAAATNTTTTAAACCGGGG

TNNNACAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGNAAAATATGTCTTTCNTTTTGNCAC^TANAANCTGANACTGAN SπsπsiNGTTGNN

GGANANGANATNACAGNTGANTTCTGNNTGGAGTTGATGAGCCCAAGGACTGGGCTGTTT GGGCCATATCCTGTTCATGGGTTTTGCCACCACTATAGAACCTTCTGTGGTCTCCCTTGCG AAAGGGGCACAGCTCGTCAGCGTATTTAAGGAGTGACCAGAGTGGAGAGCATGAGGGGA ACAAACAGGTGGGGGCTGTTATCCAGAGAACAGTGCTGCTTTCTGCAAGAACTTCTAGGG TAGTATAGAATGGTGTTGGGAGCAAAGACTTTAGAGTGACAGAGAGTCCTAACAGGTCTC

TTCACTTCTCTTGGGCTGCAGGGATAATCCTACAGGTCCCTAATCCCTTATTTGAAATCTTT TGGGATGGGTGTGTTTTGGGATTCAGGATGATTCAGATTTTAGAAAGGGAATATAGTGCCT TTATGATACATAAAGTAATACCCCAGTGAGATTCANGGCAGTGCCCTACTGTATTCAAATC TATCAATGGTTCTGTAGCTAAATATATGAATATTCCCACTTAAGTGAGATAAATAGATTTT ATAAATNGGGATCGGGACCGGTCAAAACAAAATTTTGGGTCCAAAGTTNTGAACCAACTN

TTGGTTTNTTCAAAAAATTTTTTATTTC^

AATTGGNCNCAAGGTTTTTGGGGGAGGAAATAAATTTGGCCCAAAAAANCCTTTTTNAAA ACNCCCCAATGGGNNGGNTTTTTTTNCCNATTTCNANNCCCAAAANAAAAANCCAAAGGG CCCANGG

NNNTATCTGGAGCTNCANCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGTANNCTGCCNGNCNNCNTACTTGCNTGTNTNGGANGANGGNT

NCGGCNNNCTGNGCCAACNNAATAACNNTCGCATGGCTNATGACNGGTCATGATGCCTCA GANCCCGANGNGCGGGGATNCACGTGCGATCTTANGCCTTGTGNACGGGACGCCCGCCNA

TNANGATNCNACTTTCGCTCAAAAGANNGGATATTNTNTGCGCCNNNAT ^TTTNCTGCT GCTAGAGAATCCTCAGGNAAANGGGNNGGNCGN(^TTCATANN(^ACNNNNGAANANCC NNNTTNCGCNGGNNNNNNGAC(^CTTTGNGNTNCCCTNGNATNAAAAGCNTNCGAGNGC AATATAANNCCCNTGTNCGNNAANNTGACNNCCTNGNGNNCNGCNTANNNGNGNGNGNT NAACNTCNNACNGANAGNGNAAANTACCANANGGNGTNGATNCATNCCANNCCGGGANN

TGNTGGGCTTTGNACTATTGGTGCCTGAANGCAANCGNCNNTCGGNNAGNGNCNAGANN NCAATCTNTNAGGCGNNACTGGANGNACCTTTGACTGNACTCGGCGGACCAGACNTACAN NNGAGGTNNTTGGGAGACGGACCTNTGCNTACTGNTTTCTNGNGATATACNNTTGTGGAT GAACGANTANTATNTNACGCCTTNTACCTCTNTNGNATANCCGCCATGGATGNGNGTTCC CTTNACCTTCNCCTNCGGTNCNTGGGCTCGAGCGCGGNCCNCTGGGCTTNTTTGCTTTGCT TGANGNGGGNCTCAAATCCCTTNTCGGACATTAAGGGGGGGGNTTTANCGGTTCNTGGGG GAAAAAAAAGGNANTTGCCCCCTTGCTTCAANCGGTTTTTTAACCCTTTTAANANTCCCAN GGGAGGAACCCCCCCCATTTNANNCT

NAANACTGGAGCTCCANCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCCGGCCCTGTCGGACCTGCCGGCAAGAGCGGTGATCGTGGTGAGACCGGTCCTGCTG GTCCTGCTGGTCCCATTGGCCCCGTTGGTGCCCGTGGCCCCGCTGGACCCCAAGGCCCCCG TGGTGACAAGGGTGAGACAGGCGAACAGGGCGACAGAGGCATTAAGGGTCACCGTGGCT

TCTCTGGTCTCCAGGGTCCCCCCGGCCCTCCCGGCTCTCCTGGTGAGCAAGGTCCTTCCGG AGCCTCTGGTCCTGCTGGTCCCCGCGGTCCCCCTGGCTCTGCTGGTTCTCCCGGCAAAGAT GGACTCAATGGTCTCCCAGGCCCCATCGGTCCCCCTGGGCCTCGAGGTCGCACTGGTGATG CTGGTCCTGCTGGTCCTCCCGGCCCTCCTGGACCCCCTGGTCCCCCAGGTCCTCCCAGCGG CGGCTACGACTTGAGCTTCTGCCCCAGCCACCTCAAGAGAAGGCTCACGATGGTGGCCGC

TACTACCGGGCTGATGATGCCAATGTGGTCCCGTGACCGTGACCTCGAGGTGGACACCAC CCTCAAGAGCCTGAGCCAGCAGATCGAGAACATTCCGGAGCCCTGAANGCAGCCCGCAA GAACCCCGNCCGCACCTGCCGTNAACTCAAGATGTGGCCACTCTTGACTGGGANANCGGA GAATACTTGGGATTGACCCCCAACCNANGNTTGNAACCTGGATGNCAATTTAAGGGNTTN TGNCAACATGGAAACCGGNGGANAACTGTGTATAACCCCCCCTCAACCCCANNGTNGGNC

CAAAAAAAAACTTGGTTTTNTTANCCNNNA^

GTN(^GGNNAAAACATNAAACCGGNGGGANTTNTS1NNTTTNAATNTTGGGGGGNCA^ GGCCCAANNCNTTNCNATNNGGNO^TTCNNANTTATTTTNNN

GCCCTATNTGGAGNTNNATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGTTAAGGGTCACCGTGGCTTCTCTGGTCTCCAGGGTCCCCCCGGCCCTCCCGGCTCT CCTGGTGAGCAAGGTCCTTCCGGAGCCTCTGGTCCTGCTGGTCCCCGCGGTCCCCCTGGCT CTGCTGGTTCTCCCGGCAAANATGGACTCAATGGTCTCCCAAGCCCCATNGGTCCCCCTGG GCCTTGAGGNCGCACTGGNGATGCTGGTCCTGNTGGTCCTNCCGGCCCTTCTGGACCCCCT

GGTCCCCCANGNCCTNCCANCGGNGGNTACNANTTGAGCTTCCTGCCCCANCCACCTNAA GANAAGGNTNACGANGGNGGCCGNTACTACCGGGCTGATGANGCCAATGNGGNCCGTGA NCGTGANCTTGAGGNGGACACCANCCTNAAGAACCTGAACCANCAGATNGAGAACATNC GGANCCCTGAAGGCAGCCGNAAGAACCCCGCCCGCACCTGCCGTGACCTCAAGATATGCC ACTCTGACTGGAANAACGGAGAATACTGGATTGACCCCAACCAAGGCTGNCAACCTGGAT

GCCATTAAANGGTTTCTGTAACATGTGAAAACCGGGGAGACACTGTGTNTACCCCAACTT CAGANCCNAGAGTGGGGCCANGAANAANATGNNNTATTNTNCANCNAACNCCCANAGAA AAANANGGCACNTTTTTGTTACNGGTGAGANCAANTGAACCGNCGGNAATTTCNAAATTT NTAGTATTGNNGGGCAGGGGTNCCCANACCNTGNCGATGTGGGCANACAAGNNGAANTT TTNTNGCNCTTGANGNCCACCNAGGNCCTTCCCAAAAAATNNCNTACACTGGNAGAAACA

AACGNGGCCTANTTGGGCCAACANNANTGNNGAACCCTTTAN

TTTGAGGCCNATAGNGAGTCGTATTACAGNGGCGGNCGCTCTATAACTAGTGGATCCCCC GGGCTGCAGGCCCGGCGCTGTTGCAGNTNNGNAGCCCTGCGTCTTATCTNTCCAGNCGGG

GTCCTTTGCCTCGCCACCCGCCCNTTCAACTGGCTGCGCCATGGAGGCNTACCATAAGTCT GATCAGCACAAGCTGNAGGCCNTGANGGACACAGGCCAANNGCNTGCGTATNANCNNCA TCCAAGCCACCACTGGCGGNCAGNATNGNNCCANCCNACGTCATGCTGCAGCGCTGNTGA GATCATGGNTGTCCTNTTNTTACACACCATGCGCTACAANGNCCTGGATCCTCGGAACCCT CACAACGACCGCTTTGTTCTCTGNAAGGGCCATGCAGGNACCCCATCCTTGTATGCCGTCA

GGNGATNGAAAGCNTGNNTTTCCTGCCCGNAGTNANAAGCTGCTGGAATTTTGAGGAAAG ATCAGCTTCCrø^CTTGGACGGGGCACC(^TGGTNCNTGAAAACANTGCCTTTTACCCGAN TGAGGCCANATGGGACTT(^TTGGNCCCANGGNCNTTGGAAGCCCGTTTTGCGGGNATGG CCTNCACCACGGC^ATATACTTTNNACNANAGCCACGaSTACCCGGGTTTTANTNGCNTGC CTNGGNATACNTGGCGAACTGGNCAACANGGACNTNCNNGNTGGNAAGGNCCANGGCCN

TTCNNTCAGGCTNTTNNrøTANCTTNGGANAAA^

CAACCCCCCNTGGGCCAANAATTGAACCCTTNCCCTCNGTTGTTGGNACCCANATTGGNC ANTAAACCCACNAAGNGNCTTTCTAAGGNNCMTTTNNGGNNTNGNNAANCGCCTTGNNCA TTNANTNTNAATNGGGGAOStNAANNGNGGNAAAGGAACNTNTGNCANGNGGGNNTTTr^ GN(^AGGTGGNAANGATTCNGNNCCNATNGAGGCCTNTNTTNTGGGN(^AAACNNTTTm CAGGGGACCCNAGTGTNTTCNNCAATGGGNNNNAATACG

TTTGAGGCCNATAGNGAGTCGTATTACAGNGGCGGNCGCTCTATAACTAGTGGATCCCCC

GGGCTGCAGGCCCGGCGCTGTTGCAGNTNNGNAGCCCTGCGTCTTATCTNTCCAGNCGGG GTCCTTTGCCTCGCCACCCGCCCNTTCAACTGGCTGCGCCATGGAGGCNTACCATAAGTCT GATCAGCACAAGCTGNAGGCCNTGANGGACACAGGCCAANNGCNTGCGTATNANCNNCA TCCAAGCCACCACTGGCGGNCAGNATNGNNCCANCCNACGTCATGCTGCAGCGCTGNTGA GATCATGGNTGTCCTNTTNTTACACACCATGCGCTACAANGNCCTGGATCCTCGGAACCCT

CACAACGACCGCTTTGTTCTCTGNAAGGGCCATGCAGGNACCCCATCCTTGTATGCCGTCA GGNGATNGAAAGCNTGNNTTTCCTGCCCGNAGTNANAAGCTGCTGGAATTTTGAGGAAAG ATCAGCTTCCNNCTTGGACGGGGCACCCNTGGTN(^TGAAAACANTGCCTTTTACCCGAN TGAGGCCANATGGGACTTCNTTGGNCCCANGGNCNTTGGAAGCCCGTTTTGCGGGNATGG CCTNCACCACGGCNATATACTTTNNA(^ANAGCCACGC^ACCCGGGTTTTANTNGCNTGC

CTNGGNATACNTGGCGAACTGGNCAACANGGACNTNCNNGNTGGNAAGGNCCANGGCCN TTOS[NTCAGGCTNTTNNCNTANCTTNGGANAAAATTTTGTTN

CAACCCCCCNTGGGCCAANAATTGAACCCTTNCCCTCNGTTGTTGGNACCCANATTGGNC ANTAAACCCACNAAGNGNCTTTCTAAGGNN(^TTTNNGGNNTNGNNAANCGCCTTGNNCA TTNANTNTNAATNGGGGACNNAANNGNGGNAAAGGAACNTNTGNCANGNGGGNNTTTTN

GN(^AGGTGGNAANGATTCNGNNCCNATNGAGGCCTNTNTTNTGGGN(^AAACNNTTTTN CAGGGGACCCNAGTGTNTTCNNCAATGGGNNNNAATACG

TTNANAAANGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGAGGTCGCGGAGGCAGAAGGCGTTCCTGCCCCTGTCCTC GTCACTATGTAGCTGAGGGGCAGGAGGCCTGTTCCACGTTCTGGAAGGTTCTTGGGCTCG ACCACGGCAGTAGCCCCAGGACTTCTAGTCCTTGGCCTCGGATCCTTGCCGGCCGAGGGG AGTCGCCGCCGCCATGTTCGGCTGCTTGGNGGCGGCCAGGCTGGTGCAAACAGCTGCACA GCAGGTGGCAAAGGATAAATTGGTTTTTGACTTGGCCTGATAATNAAAATATCACCCTTGT

GGTGGTTTTAATGCTGGNACCAGTCCCTTTTCTGAAGGAANGGAAGCTCTGGCTACTTTTC CTATCTGATTCAAANGAATGCCNGTATGGCAACTTCTAAGNATTGGCCACNATNGGNAAA CCAGTGGCCNTNTTNAAAATTCAGGTNTTAATTTNGGNAAGGAACCCACCNCCCGTTNGN ACCCTTNATATTGGCαsiNACTTCNNTTNGTGCTTNAAATNGGAATTCAANNGNAATGGTN GCAAGGTTTGGTNAACAAANCTCTGGGGGGAAAGNTGGTGGGGCCCCNAGTGGACCCAN

TTACTTAATTTAACAAAAAAAGC(^GGNCCACCTTTTAANAAATTTTGCTTTA^ GTNGGCCTTCAAGGNCCCANANTNAACCCCAAGTNCCCTTTTGNAAATGGTTNNTTTCCCN NCAAANNNGGGGNTNTlSπNrAAAANGGGGNNNGAAAAACNT^^ NCNNNTNTAAACCCTTTTTTTT^ AGGGGNTNNTIWAAAATTTNGNNNTGTTT^^

CTTTAAANNNCNNAN

TTNNANAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGAATTCGGCACGAGGGTCCTGTCCCTCTTGAATCTCCCTCCCACTTCCCCTTGCT ACATTCTTGTTTCTATGGATATATGAATAATAAAGACCGTTGACTAAAATAACATGAAAA GCTCCCACACACAAGTGTGCACGTGCACACTCCCTTGTGCATTATTCGGGTCCACGAGAGG GCCCTGTCCCCGCAGATGCTGAAGTGATGGAGCCTCTTGTCTCCGGAGCCAAGGGCATGA ACACACTGTCGGTCGTCCTCTAGGGACACCTATGCTTCCGCCTTCTGGCCTTTCCATTGCAT

CCGTCCGTTTCTCTAACAGAATGTCCCTGTGATGACACGGGCTCCCGTTACCAGCTCTGGC TGTCTCAGTGAGAGTACAGCTTACCCTCAGCACTCTTTATTGGCCCTGGGAAATTTTGCTT CAGTACTTTATTGAAAGAAGCAATAAATAATACTGGGGATAAAAATAGTTCAAAAGTANA CTGGACATACTTTTGTCACATATTNGGGAAGTTNACAAAANAATTANTNGGAAAATNGAA TGATACCATTGAATTGTNCAAGGTAAATTAAAGGCGGAACCCCATGTAAAGANACATGCT

GTCTTTTGTNTACCGAAANACCAGCTGCATAATAAATTTCGCNCCTTGACCTGGAAAAAA AAAAAAAAAAAAACTGNGGGGGGGGCCCGGGNCCCAAATTCNCCNTAAAAGGGGGGNN NNNNNANAANNNNNNNNNNNNNNNNNNNNNN^ NNN>INNNNNNNNNNNNNW NNNISINNNNNNNNNNNN^

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGCTACACCAGAGGCGGCCGAATCATCTCCACCTCTTCAC GCTCCGTGATGCTACATTACCGCTCAAGCCTGCTCCAGATGCTCGACACGCTGGTCTTCTC GAGCCTCCTGCTGTTTGGCTTTGCGGAGCAGAAGCAGCTCTTGGAGGTGGAGCTATACCC AGAATACAGAGAGAACTCGTACGTGCCGACCACCGGAGCCATTATCGAGATCCACAGCAA GCGCATCCAGATGTACGGAGCCTACCTTCCGCATCCACGCCCACTTTCACTGGGCTCAAGG

TACCTGCTGNACAACTTTCCCGATGACCTGCGCCTTCGTTGGTGTCGCCAGCAACTTTCAC CTTCTTAAGCGTANTTGGGCTCTTAAGCTACATGCAGTGGGTGNGGGGGGGCATCTTGGCC CNACAGCGCCTTTTTTTGNAGGTAACATTCCGAAACCGAAAACGTTCCCGCANGGACATT CAAGCGAAAAGGGTCTNTGCCAATAANCCAGGGCCCCAAGGCCAGGANGAGTCCCCCCC AGCTTGTCACCTGGTTACAGAAGGACGGNGAANAGCCACGCCGGATCCCTTTTGGGAAAA

AAAGGCCAGCTTGTCCGAGGAGGGAAAAAACAGAACCAACCGGCCCCTTGAATGGGCAA GGAAGGAACTTGGAANCCCCAAGGCCAAGTGATGGTTCAAGGCTCCTNGGNAANAAGCA A(^TTTTGNTGAACGGAAGGCCAAACCTGGGNTGGCTTTTGGGTTTTTGNCCCCTGGNCCC CAAAAAAACCGNGGGGCAAGCTTCGGAAANCCCCTTTTGNGGGCTTTTTTNCCNAAAAGN GNCCCCAATTTTGGTTCCAAATTTCTTTNAAAACNANATAAGGGNCCCAANCCCCCNATTT

TTTNGGGCCCTTTTTNCCCCCCGGGTTTTNTTTTT

AAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GTGATCTACAAATGTGGCGGGATCGACAAGAGAACAATTGAAAAGTTCGAGAAGGAGGC

TGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAACTTAAAGCTGA ACGTGAGCGTGGTATCACCATTGATATCTCCCTGTGGAAATTTGAGACCAGCAAGTACTAT GTTACCATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGCACA TCCCAGGCTGACTGTGCTGTCCTGATCGTTGCTGCTGGTGTTGGTGAATTTGAAGCCGGTA TCTCCAAGAACGGGCAGACCCGTGAGCATGCCCTTTTGGCTTACACCCTGGGTGTGAAAC

AACTAATTGTTGGCGTTAACAAAATGGATTCCACTGAGCCACCCTATAGCCAGAAGAGAT ACGAAGAAATTGTTAAGGGAAGTCAGCACCTATATTAAGAAAATTGGCTACAACCCCGAC ACAGTAGCATTTGTGCCAATTTCTGGCTGGATGGTGACAACATGCTAGAACCAAGTGCTA ATATGCCATGGTTCAAGGGATGGAAAGTCACCCGTAAGGACGGCAATGCCAGTGGAACCA CCCTGCTTGAACTTCTGGATTGNATTCTGGCACCACTTGNCCAACTGGACAAACCCTTGNG

TTTGGCTTNTCCAGGATGTCTATNAAAATGGGGGGGATTGGNACTGGCCCTTGNGGGTCG NGTGGAAAACTGGTGGTTTTCAAACCTGGCATGGGGGGCANCCTTTGGTTCCAGNCAATG GGAACCAACTGGAANGGAAATCTTTNAAAAAGGCCCCCTTGAANCNTTTGNGGGA

GCCTATAGNGAGNCGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTCTTTTTTTTTTTTTTTTTNCAAAAT^ TTTTNNCNNCCCCAGNCTNNNNGNNTTTTTTTTNA^ GTTNGGNNTTTTTAAANNGNCNGGAANCCTTN^ AAAAGGGGGNNTTTNANNANAANCC TGGANNNAN(-^CCCNNANTSrCCCAAAAAAAN^

TNNNNGAANAAAGGGCTGAAANCCCCNGGNCAANGGGGGNNNCCCCNTTTTNNGNGGGG NNNGGGGGGNNAANCCCNTNCαsrCCNCCNAAANNGGGCTNAANTTAAAACNTAAAAATT TNGGTTNGGGAACTTNNNNNTTAAATTTTNCAAANGGGNNNNGNCCCCNGNANT^ C(^TNGNAAAANNGGGCCCNNNGNNNTTTTTNNTAAANGNAAAAGGGCCCCTT^ NGGGGGNNNNAAAAAAANKGGGGGGGTTNCAGNAAANAAAAAATTTNTTTTTNNC^

GGGGGGGGGGGGGGGGNAAAAAAATAAAAAAAGNNTNNGGCCCCCTTTTTTTNTANNGG NCANNANNAAAAANGNANANTTGGGCCCNGGTNNAACCTGNCNNAAAAAANNGGGGGC TGGTTNACCCANNANNGGGGGGGGNNAAAAAAAAACCCOS1NNNTTTANTTAAAACCGNN NNTNTTTNANCCCCACCCCCCNNAAANCGGAAANNGGNNTCCCANANCNCGNCGNNGGT GGCCCCCCCCCα^AAAAGGGCCAAAATNNTNGAAAAAACCCCCCAACCCNNTAANANGG

GGGGGNGCCCCaSINNTCTTTTTTTTTTTAAAAAANGGTNGGGTA^ CCGGGACACCNNGGAAACCCTTNNGGTTGTCCCCCCNTTTTNTNNGNNGNT CCαsrCOSTNCAGGCN(^TTTNAC3SπSlNNANNTTTTT^

CGGNNGCCCCGNCTACTCCNCTTNNGGGGGTAC<^GNCGNNGC3SINCNCTNCNTTGAGNNN CACTGGACTNCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGC AATTCGGCACGAGGCTTGGTGATAAGGCTCCACCAAANCCTGTACCCAAGACTATTGACN ACCANNGAGTATATNATGAAACCATAGTACATCCTATTGATGAACAGGCTGCTTATGATG

AANCTACANATNAATNTGCTNNTTACTTAAANACGACANACTTCTCCCAANATCTCTCATC NCTACNTCANCATANACCTCATGGGNANAACAGTACCNACTNTGNGAACANGCTCTCTAC AGGTATACCNAANNTTCGCATTGTTTATTAGCrø^AACAANGACTTGCCTNTNGAAAACNN _{NTTAτmcCACA1WGCAΩWTrA}TNNAAATTT^ AAGANTCGTGAAAANTACCATAAANGGATTAAATTCATGANNNCTACCTGGTTTCCAAAC

NNNNTCTNAANCNTGCGTTNCACATTATANNNAATTGANACCAANTGGNCCGNNCTNNCC NTTCAAANGAATNTTTANNCATNNANNGCCANATN^

NTAACCNCNGAAAANNNANCNACNTNNAANCNATCCTTCCCAANGCAACCNNCTAGTGN ATCCANGTCCTNACTTCGGTAATCTTATANTNGGAGNCA(^TCANCTTGTTTTNNCCCANT NAATGNGCTNATAGNTNTNTA NTNGN INNAGGCCTNNCTTNTGNCCNATCWACTTTCTC

NACNAATCNATACGGGANANTANATTAATTNTTCTTNCNNANGAATCTCCGNANCACATN CCTNTAATNTTCNAAGAATCCCNCCCATGACANNNCGNGCGNANTTATTCGNATNATNTT TAGAANCCACNNGTNTTTGAACGNTTNAAGNNCATNGNACTNNAACNATNTCTANATAAC NATACNNGGCCGATNNTNTTGNNTGαSTTCTT(^TAσSIACNGTANTNGNAGAAAATTATGT ANGANNGCTACGNGCTAN(-MNTAATATNCCTCNNGACGGGAGCTTAANTNTANTNT^^

ANTGTTNTNCGAAGNTACNTACANTATCNACGCATTNTGTNGTCGTATNCNCCCACGNTCT CTANGNNGAAACNTATGTCNN(^TNCGCTANCNGCNNNNNNCACTCTCAGNTANCGCNCN TGNTCCGCTNTNTTNTNAOSπNANN(^CAACTATAANTGTN(^TTNGCNGTAACNCCACTTC TCNNAACGTCTt-MSfGCNNANCATACGAAATATCGTTTTCGCTTTTCNACNGAATGNCCNCT CTATCGNTACNATCCCC

NAANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGTGGTTCAGAGCTGCCTGCCCTAACTTCCCCTTCTTCAGCGTC TGTTTTCTCTCTCCTTCCTGCTTGTACCTCCCCATGCTCCCTGCTCCCCCCTCTCCCTTCCTG

ACCAGGAAGGACATGAAGGGTTGAATGCCAGGAACAAATGACAAGGAAGCCCTCAGGAG GATAGGGCCATCTGNGGGCTGANCCTTCTGNCTCCCTNCANCTGNCCCGNCTNCAGGCCC TTAAANGGCACATNANGGGGGNGNGCTGNTGGGTGGGTATNCCACCTNCANCCCACANN ACTCATTTGNAATTTTTATTATGCTGGAATANCTATTTTTGGTTCCTTTTT^ GGGGNATGNGNGNGNGTATGNAAATATATAAATAGCGAGNTTCATTAAAACAGACTGNC

CCACACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAANAANNN CNNGGGGGGGGGGGGNNNCCCCCANTTNCNT JNTNNGGGGGGGGGNAAAAANNNNNNN NNNNNOSπSINNTSπSINNNNl^NNNNNNN^ NNr^NNNNNNNNNNNTrWNNTNNN^ NCOT^JNNNNNTNNNCNTNNNNΓWNGNNNNNNN^

TNANNNNNTNTNNNNNNN^

NNNCNNNNNOSINNNNTNNNNANNNNNNNNNC^^

NNNGNNTTNOSINNNNCNNNNNGNNNNNNCNN^

TTTNAGCCCTATAGTGAGTCGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGGATCCCC CGGGCTGCAGGCCGNCGNTGTTGCANNTCCGCAGCCNTGCGTTTNANCTTTCCAGTNTGN GTCCTTTGCNTNGCCACCCGCCNNTTNGCNTGGTTGCCCCTNGNAGGCNNACNTTANNCN NNANAACAAAAANNNGNNGGCCTTNAAGNANCCGGCCAACNGCTNGNTATTAANTTCAT TCAAAGCCACCACGGCGGCNGNATCGGGCCACCCCACGTTATGCTGCAAGANGTGCTGAT

ATNATGGCTGCTCTTTTTTTNCACACCATGCTCTANAGGGCNGTGNATCCCNNNANCNCTC ANAANNACCNTTNTNTTCTCTANAGGGNCCNTGNGNCN(^TATTNTGTNTNCCGTNTGNT CTAAATNTGTNTNTNTGCCAGAACAGATCTGNTGNATNATGANGAATANCATCTNCGACN TGGACGGGCACTNNTGTCCAANAAACAAGTCTTCACCGATGGNGNCNACTGGCTTNCTGG NCCAGGGCCTTGNAGCCTNTTGNGNGATGGACTACACANGCNANTNCTTCCACAANAGCC

ACTACCGGGGTCTATTGCTTGCTGGAAAGACGGGGAAGCTTGTAAGATNCCTCTGNGAGG NANANTGAATTTTCTTCAGCATTTTNTC^

TTGACAACCAACCGGNCNTGAAAAAAGAACCNTNCCCTGNCTCGNTGGCCNAAANTNGA ATGNGNAATCTANAAANNATTNNTTTGGOSΓATTGCCTTTGGGAAGGTANCNCTTNTTT^ ANNGGNAGGGCCNCAAGNTNGNAAAGGANNCTTGGGCCNTGGCCTTTTTNGGGANGGNA

AAAAAAACCCGNCCCC<^TNTNTTTTATTTGGCCANA^

AAAAGGAGATAGAN

TTTNAGCCCTATAGTGAGTCGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGGATCCCC CGGGCTGCAGGCCGNCGNTGTTGCANNTCCGCAGC(^TGCGTTTNANCTTTCCAGTNTGN GTCCTTTGCNTNGCCACCCGC MNTTNGCNTGGTTGCCCCTNGNAGGCNNACNTTANNCN NNANAACAAAAANNNGNNGGCCTTNAAGNANCCGGCCAACNGCTNGNTATTAANTTCAT TCAAAGCCACCACGGCGGCNGNATCGGGCCACCCCACGTTATGCTGCAAGANGTGCTGAT

ATNATGGCTGCTCTTTTTTTNCACACCATGCTCTANAGGGCNGTGNATCCOSnWANCNCTC ANAANNACCNTTNTNTTCTCTANAGGGNC(^TGNGNCNCNTATTNTGTNTNCCGTNTGNT CTAAATNTGTNTNTNTGCCAGAACAGATCTGNTGNATNATGANGAATANCATCTNCGACN TGGACGGGCACTNNTGTCCAANAAACAAGTCTTCACCGATGGNGNCNACTGGCTTNCTGG NCCAGGGCCTTGNAGCCTNTTGNGNGATGGACTACACANGCNANTNCTTCCACAANAGCC

ACTACCGGGGTCTATTGCTTGCTGGAAAGACGGGGAAGCTTGTAAGATNCCTCTGNGAGG NANANTGAATTTTCTTCAGCATTTTNTCAACN^

TTGACAACCAACCGGNCNTGAAAAAAGAACCNTNCCCTGNCTCGNTGGCCNAAANTNGA ATGNGNAATCTANAAANNATTNNTTTGG(^ATTGCCTTTGGGAAGGTANCNCTTNTTTTTN ANNGGNAGGGCCNCAAGNTNGNAAAGGANNCTTGGGCCNTGGCCTTTTTNGGGANGGNA

AAAAAAACCCGNCCCCCNTNTNTTTTATTTGGCCANAACCTTTα^GGGGCCCNNANTTTT AAAAGGAGATAGAN

TNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGCGGGCGCGGCAGGAGCTGACATGGACCCAAATCCTCGGGCAGCCTTGGAGCGC CAGCAGCTCCGGCTTCGGGAGCGGCAGAAATTCTTCGAGGACATTTTACAGCCTGAGACG GAGTTTGTCTTCCCCCTGTCCCACCTGCATCCTGAGTCGCACAGACCCCCCATAGGTAGTA TCTCATCCATGGAGGTGAATGTGGACACACTTGAGCAAGTGGAGCTTATCGACCTGGGGG ATNAAGATGGAGCGGATGTGTTCTTGCCTTGTGAAGACCNTCCACCAACTCCCCAAACGTT

TGGGGTGGACNAGCGTCCCGAGGAGCCGNAGCTTGCCAGTGGCCCACGCCAGAACAGGA ACGNACGTCTCGTAATTTCTTCTTTGTCTTCCAATTCTTCAACCAACCAAAAAAGGGCCNA TGCCAGTGGACGGCGGACCAAAACACGCCCCTTGGCACANTCTTGACAAGGAGAAGGAT GGAGGCCTTGATGGCGGGCAAAAGCCCGAANCTTGCAGTTAGCAGCGGNCCCCCACTTAC AAATTGGGGGAGCTGCCTCGTTTCCCTGGGAAACCCCAGGCCTGGCCANAGCCCTTTGGA

AAAAAACCAAACTNTTTAATGGCANTAGGCACCAAGGGGAAGNANAGCCGGCCCCCAAT GGTGTGCCTTTCTTGGGAACCACCCC<^GTTCTGGCTTTAATGGTAACCNTTCCCCTGGTG GGATCCTTTTTGGTATTNGNTAAAAAAATTTTGGGAAATTAACTTGGGCC^Tπ TAANTTTTGAAACAAAAANANGGNCCCCTTGNTTTTANGGGGGGANAAAAAANTCCCNA ACNCCCCCCCGGGNTTTGGGTTTAATGGGTGAAANGGGGGNCCCCCCGNTTGGGGGAAAT

GGGAAAATTA

GAAAAANCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGNNNNCGANNTCATGCTTNTNNTANTNTTTANNTNGANGGGGGNCNNGGTTCTCANGG

NNNCCTANAGNGGGGCGAANNNCATGAGCTCTAGCCNTGCCNTGANATGCCCATNCNTN

AAAAAAANNATGTNNAACCAGNCCCCANNGAAACTCTGNGNCCCNNNAAAANTTTTTNTT

NTTTNNNCNGNCGTTTTAGGGNCAOSf^

CCATGCCC^TGGTTAAAAAAAANNNTTGGNNCNGATNNTTNCCCCCAGNNCAAANATGG GNGNNCAGATNTNANAAAAAAANNTNTNTTGC1TGNGC(^CCANTNNGNGNNNNNNTGG

GNNGCTGTGCCCCCCACCCAGGGTNTTTGCCTNCCCTTTAGNAGNACACCCCACTGGACCT

GTGCCCCCAACCACOSIAACATNAACCCTCCAANGNAAAAAAAAAAAAAAAAAATTTTTTN

GGAACCCANGGGNCNTTTTTCANAAANNTNTTNAANNGGGNGGGGGGNCCCCCANTTTTN

AAAAATTTGGGGGCCTTTTTIΥrCATTTTTTTπ TTTTTTTTCNTNAAANNAATTTNNAAAAAAAANGNGGGGGGGNGNNGGAAAAC^

GANGGGGGNTTTTNNCCCCCATTTTTTTNGGGGNGGGGGGGNGGGGGAAAAAAAAANNN

CCNC⁽_NGGGNTGTTNGAAACCCCCCCCC(_NCαsrGGGGG

TNCCCACCCCATTTTTGGCCAAAANANAANTTTI^^ AAAANCCCCANTTTNCCCAAAANGGGGGGGCCNCCCCCAACGNNGTTGGGGGGGGGGGT TTTTTNAANNAACNTTTTTTTTGGGGGGNN

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGATAAGAACTTGACCTGTGATTNTTCTCTCCCTNCCCTCCCNCTGCANGTGTGGGTCC TAGGAAAGGACCTGGNNCACCTTGGGTNGAAACTCAAAAAACTTTCCGANGCNCCACCAT NAGCNGGNCCCAGCTGAACACT(^CCCGTGTAATTTTAAACATCTAGCANTANATAATTG NGGTGGTGACATAAAGGACCCTGNTTCTGTAGAGAGAAAAGCTTANCATAATTGTTGTGA AATGTAACATGANGCAACTAACTNGNANTTTTTT^

AAATAGANTGATANAACTTTGCCAGNCTTTAAAAANCTTGGCTTAATTNANTATATTAATC TGTCCGTGCANAANTAAAACCANCCTTTAAAAATGTTAGGGGAATNAATTNGAAGCTGGC GAATAGNAACTGATTTΓAAGTTTGGTATTATGAAACATTNAAGGGCTTTTGTCCCCTAATT GATAATCATGTTTAANANGTAGTCATNTGCGGGTATAAGCTAGTGTTGCTTGCTTGCANTA TTCATTGCCCCCTANANGAAAGNGAAAATGGATTGGNATGGAACCCCCCAANTTAAAGTA

AAAGAATGGNTGAAGTTTTTTTTANAAATTTNCCCTTTCCAAANTGGAAAACNNCCT^ AACTGGGCGGGTTAACAAATACCAAAAANAANGNTGGNTTTTNTTGGCCCTTGGGAAAAA AATTTAATTTCCCCCCCCAGGTTITT JNTSFNNCNGGGGGGAAAAAGGGGGCCΠ NAACTTAAGGGGTTCATGGCCNTCCNTTTAAANAANCCCNGGGAACCGNNTNGGCCCTTC CAAA(^TTTTTTNNNCCANGNGGGGTTTTTTANGGGGGGCTTTCCCCCCGGGN^

CTCCCCAAAAAG

TTGANAANNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCTACACCAGAGGCGGCCGAATCATCTCCACCTCTTCACGC

TCCGTGATGCTACATTACCGCTCAAGCCTGCTCCAGATGCTCGACACGCTGGTCTTCTCGA GCCTCCTGCTGTTTGGCTTTGCGGAGCAGAAGCAGCTCTTGGAGGTGGAGCTATACCCAG AATACAGAGAGAACTCGTACGTGCCGACCACCGGAGCCATTATCGAGATCCACAGCAAGC GCATCCAGATGTACGGAGCCTACCTCCGCATCCACGCCCACTTCACTGGGCTCAGGTACCT GCTGTACAACTTCCCGATGACCTGCGCCTTCGTTGGTGTCGCCAGCAACTTCACCTTCCTC

AGCGTCATTGTGCTCTTCAGCTACATGCAGTGGGTGTGGGGGGGCATCTGGCCCCAACAG CGCCTCTCTTTGCAGGTAAACATCCGAAACCGAAAACGTTCCCGCAAGGACATCCAAGCG AAAGGTCTCTGCCCATCAGCCAGGGCCCCAAGGCCAGGAGGAGTCCCCCCAGCTTGTCAC CTGTTACAGAGGACGGTGAGAGCCACGCGGATCCCTCTGGGACAGAAGGNCAGCTGTCCG AGGAGGAAAAAAACAGAACAAACNGCCCCTGAATNGGCNAAGGANGAAACTTGGAACCC

CGAAGGNCCAGTGATNGGGTTCAAGGCTTCCTTGGGGAAAAATGCAACTTTTGGTTGAAC GGGANGGCCAAACCTGGGCTTGGCCTTTTTGGGCNTTTTGGCCCCTGGCCCCCAAAAANA ACCCGNGGGGCNAGNTTTCGGNACCCCCTTTGGNGGGGCTTTTGGTCCNGAAAAGGGGCC CCNATTTTGGGTTCCANTTTCCTTNAAACCAAATAAGGGCCCCAANTTCCCCCNTT

GNCCTANTAGTGGNGTCGGTATTAACNGGGGGCATNCCNNATTTATCAANTTNTTTGTNTT NNCNCAATCCNAGNNTCCNAACTTCGGCNCTCTNANGαSINTNTTCCCTACCCCα^TTCNCC NACANTNTCCTA(^TTCGTCNTAAATGGNGTCTCTTNTNGNCCGCNTACTCNNCATNCTCT CNTTNCNCTTNCCCCTCTCTT(_^TTCGTTTCACGGTCNCATCNNC^CTGGGNGTNGNNTAT

GAGNGNNNNTCANATTACTCTCTCNCNCGGAGNNCCTCTACTTNCCNNNAGNNNNNCCTG CCCTCGATNNGTCTGTNNANTATNNCNCNNNNNNNCCTANTGACCCCAGNGNNCTNGCTG TCCNNTATCTNNNNANNAN(^TNNTCANGNAGGGGNNNNNNTNTTNGANCNGGAAT^ NNAGNNATNGATATNGNNTAGGNGNGCTTNGNACTCGNANGTAGTNGTNNGCNNTNTGG NTNTAGAATNANAANNOSINNGGNATACNTNTGNNCTGATTTNNTGTCNGTCCNGCNNGTN

AN(^CTNNTNNNGGTNCATATNTNTTNTNCCGGTTGTNNGANGTNTNCNATTANTAN^ CNGNGNNAGNNTTNlWTANA<_MSrANGN^

TNGNATαSfCTAGNAGGAAGGCTGNCGAANCGNTTNNNGNGGNCTGGNNGANNNTOSINNG GNGGNCCGNNNNNGNTNNNGO^NNGTGTNCGNNNANTAANANTATNTNANNNATCNNNT NGT(^GCTGGGNNATAM^TANCGACWTGTCNNTANCGCNANNNCGGNAANNGNGNCTNT

TNTAATTNNTATNCAGNGCNCATCATGGNGNNATCAAAGANTCTNNCNTGNNNACCAGCA NNCAGGGCGNGTNAGGCANTTGNCHNNTNAGTCCNNGTNOS1NAGNTNGCNTGAAGNNCA ATTTGNNNTTNNCNCGNGCCCANAATTGNCCCCATNNTGNNNCTNTAGNCNNCTGNNGCA NOS1NGNTNGCCNGANACCNTNCGTNNTGNCCACAANNTGTNNGGGTCTNNTAGCAGTGN CNNAGCGCGCGGTACTGTATCGCGCNCANACGCGNCCCANGGACCNNCNNGTGTGCANT

NACNANNTCTCNNATNACTANNNAGNCGANANNGTANANAATGCGNNTSfANAGNNNACG

AGATGTNCGCATNTNGAGNNAGAGAACAGGGTGNCTGTNNGCGCGCGCGNGNGCNCACG

CAGATCGTNATAGATATACATATANANNNTCTTANCGGGCGCGATNANCGCGNNNCNCGA

CGNGCG(^NNCGGCWWCGCTGGANTGTCNNCNANNTAGNTNGTCTCGNTTNCGTGTNNGA

CGNNGANGNANGGANTCATGNGNNTNTNGTTCGTCGNCCG

TTTGAGCANCATCTGGAGCTGCACCNCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGCACTCGCTCGCAGTTCGCTCCGCGCCCTCTGCAACCATGTCTGACAAACCC

GATATGGCTGAGATTGAGAAGTTCGATAAGTCGAAATTGAAGAAAACGGAANCGCAAGA

GAANANNCNNNGTCTTαrøfANANNNGACTGANCNAGNNACACTNTGTA(3SπSfTAGANNT

AANGGANANTNCANTGTCININAANNCCANCTTC^

NNNTNTCTNTOTCNTTTNCTNA^ NNTTNGAGTNGCCNTNCCNNTNNTNTTGN^

AANNCCCNTCNTATNCTNANTNCACN(^TTNCNCNTTAGANNNNAGTNNGGNNTCNAGAT

CAGCTTNNATANCNGANTOSINTGTANN

NATTTNANNGANTGTTTTGANCAGNATNTTNANACNNNCGTTTACTCNNNCGCNGGAGNT

TCNAGNTNNNNGNGCTCTTNTNTTNNGACACANNTNANNNNCATGNCTTGCNGTTGTATC TCNCGATNTTTNCNTANANTANNTNNAATGCATNNNGNCTGTTANNNCNANGCANTNGTT

CTNTATCNNNAGNNANNTNGNTCNANGANTNCNNNANGTATTTATGGTNCNCNNCTGNNT

CTTACM^TGACCNANTNGNNATTNNANNCTGNNNNTCGCNNNTTTTTNTNGAT^

CACANTCTN(^GTNCNTNNNATNCAGTTTNNNAATNTCTGTNTNNGCTNNTCGAGTC^

GTTGNTTTNTCCCNCrøN[TGTNCTCANCTTTGGANTNGTCNTATAATAACCTNNNTGTCNTN NTNAGGATNTANNCTANNTTTCTCNGTACTTNTCNTCTCNNTTNTCCCCTAANTTTTNTAN

NCCTITTCΪWTGTTNNNCNATNNTTCGNTCTNGGNGANCGANNACTATCATANGTNAGCTT

TCNCTATATNCNTCTACGTCG

NTATANTCTAGANGACNTNNAC^ANCNNNC^ACTATNNTNCAANNCTCTCCNCACTNNTT

TTNGAAGNTACCCATTAACGAAGNTTCANCCNCTACAGANGGNCATTTCTTNTNCCNTCNT CNCTCATCACAGATNTGCANNCNTACACTCCACNNNNTTNCTNNTNCNCNNANAACCNTN NNNOSINTTNTTTNACNTATTACTANCA(^ATTNCTACANATCANACGNTACCCGNGNNNN CTNCTACTTTC^αsiNCTAATANTTTANAANACACTANCAATCAANTTATACTC(^TTTAAN TTCANTATANTTNTTNANNNNCTCNNTCCCACACTACTTCTACNCNTCTTNCNANTNTTTA

ANNATTNCTTATTATATNANNCCCNAGTNTNCNACNT1WANNNTATATATNTTTCTAAANN NCTANTNNGCCGNNNANACCNCAACCAACCTTNTTTTCTCNAATNGTCCTGCGCNGNCNT NNrWCAANTTATANATNANACATNNNNAlWN^ ATATCTNNNNTTANCCCCNTANAGACTCANCNTATCANNCAATATTANATATCTANAAAT ATαsπsrCATCNANTCATNTACCTTNN^

TNNTNANTNNTNTTNNATNTANACTAATANAANCNNNCCACGACCNGCCAANTCNNTCTN TTNTNCNNCTACNNANNAGCTACTANCGNCTNCNNTCANGTNANCTTNNTTCTACNAATC ANNTCNATNAANNCCACCCCTANCCNCTNCCNANNCTTCNCTCACCTTATNGCTATTCGCN CTNCCCNNCCTTNTNTNTTCTCACCTGTANCNTAGANGNNNANNCGNNNCCCTNACNTCT ATANCCNTNNGTCTTTTANNNNANACTANNNNGTATCNNCAANNNATNANGTCTCTNTNG

T(^TTCCTTCCGNCAACATATCANACNNNNNANATNΣSΠSINCCNCTTCNANCNATTCCAAC TNTTTATTCTACATTATATTTANACO^NNNNTTCTCNCCTGTTACCTTN CCΠSITACTNCΑ ACCNATATGNCACCNGNCTCAANCATCTANNTACTTATANCATCTACAAT NATNTNTANGATCGN(3NNNTACNCNATNTATNCANNATACTTTCNCTNGANTNNNGCNNA TNNNTTΓ(^TATTATTTANNTCTNCTCTNAANTTANCCHΓACAGNACNNCGAANNT^^

TNTANTATCTTTOSINACANGTATTCANTCAGNACNATNTCTGGCTTTACATCANAATTCTA TCAANATNNAATGCGCTNNNTTANNTANTCANNNTCTTNCTGCACTCAT }NNTCTNTN^ GACTANNNGCNNNATNTNTCNNTNTCTNTGAACNTACAAATATATAAATNTGNNATCCTC N(^AGTNTAT(_MSFTTTATNNAN(-MTATACACGCCTNCGANNCANNANTNTCCATCTCANC TCATNTANATCTCTANAANAACNCAAAAATNTITACATNTATNNNATANNTATNNAATAN

ACATACGNTACATTATTNCNGΑSRATNNTATCNCNTNACACTACNANCATNCTAATCCTCTA CGACGNCNTNACACCATACATNNGATATACNACAANATATATNA(^AATΑSINNAAACNA

TCNGCG TTNAGCCTATNGGGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCN

GGC^GGNNGGTTTTTTTTTTTTT^^

NGGGNAAAANCCGGANNCCMNNNCCNNGTTTNNG NTTNNTTTCrøAAANNGNANNGGGNAATNCCN^

NNAANNACC(^GAAANCCTTTAAANNAAAANNNNTTTNNCTNAATTNAAAAAG

ATTTAAAAAAAANNGGGGGCOSITTNNAANNAAAANGGNNNTCCCAAANNNNTTT^

ACNGNMSINCCNCCAAAAAAAAAATTC∞

NTNINNNNNGGNNAAANGGGGNNANN<- ACCCCGGG AAANGGGAAANCCCTTTTNGGGAAGNNCAAAGGGGGGNCCCCCCCCCTCCCNAANNGTN

(^GNAAGGGCCCCTTTTNTTTTAAAAGGGTTAAAAACCCATTITNGTTTCCGNCC

CCAATGTGNGGGGGAAAAANCCNAAANAANNNNNNTTTGGGGGCCCNNNCCCCGGGGAA

AAAAAAACCCTTCCGATATTTGGGGAAAAANNGGGGGGCTTAAAGGGGCCACCGGGGTT

TTTNGGGGTTTNNCGGGGNGGCCCCCCCCCCTTTTTTTTCTCTGGGGGGAAAAAAAAA^ GNNNAAAANC(^AGNCCCNTTTTTTTNNAATNNNNCCO^

CCCCCGGGGGGAAAAAANNTTTTCNCTGGGGTTGGGGGCCCCCCNTTTTNGGGGGGGGAA

AAAAANAAAGGGNGCCCCCCCCTTTTAAAGGGGNNCCCC<_^^

TTANAAGNGGGGGGGGGNTC

TTNAGCCTATNGGGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCN

GG(^GGNNGGTTTTTTTTTTTTT^^

NGGGNAAAANCCGGANNCCNNNNCCNNGTTT^

NTTNNTTTCCNAAANNGNANNGGGNAATNCCNAAANNAANNCNNGTTTTI^ NNAANNACC(^GAAANCCTTTAAANNAAAANNNNTTTNNCTNAATTNA^

ATTTAAAAAAAANNGGGGGCCNTTNNAANNAAAANGGN^

A(^GNQN1NNCC^CCAAAAAAAAAATTCCGGGGGGGGGNNN(^^

NNNNN^GG NAAANCKKKSi-WA^^

AAANGGGAAANCCCTTTTNGGGAAGNNCAAAGGGGGGNCCCCCCCCCTCCCNAANNGTN (^GNAAGGGCCCCTTTTNTTTTAAAAGGGTTAAAAACCCATTTTNGTTTCCGN

CCAATGTGNGGGGGAAAAANC<^AAANAANNNNNNTTTGGGGGCCCNNNCCCCGGGGAA

AAAAAAACCCTTCCGATATTTGGGGAAAAANNGGGGGGCTTAAAGGGGCCACCGGGGTT

TTTNGGGGTTTNNCGGGGNGGCCCCCCCCCCTTTTTTTTCTCTGGGGGGAAAAAAAAAAG

GNNNAAAANC^AGNCCCNTTTI^^ CCCCCGGGGGGAAAAAANNTTTTCNCTGGGGTTGGGGGCCCCCCNTTTTNGGGGGGGGAA

AAAAANAAAGGGNGCCCCCCCCTTTTAAAGGGGNNCCCCCNNCCTNT^^

TTANAAGNGGGGGGGGGNTC

TTGAAAAAATCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGNNNTCGCGNCNAGAGCTNACATGGACCCAAANCCTCNGNCNGNCTTGGNGC GCCAGNAGCTACNNNT WGGGAGCGGNACAAATTNTT^WANGACATTTTACANNNTGAN ACGGANTNTGTTTTNCCCCTGANCAACNTGNATCNNGANTNGTACANANCCCGCATNGNT ANTATCTNATANNTGAATGTGAATGTCAACGCANTTNNNCAAGTGNANCTAATCGNANTG CTGGATCAATATAGAANGGATGTGATTNTGTCCTTGGGAACANCNTACANCNNNTNTNAA

GANGGTTGGCCGNNANCAANCΑSTITSINTTAGGTTNNGACCTNTNNCAGTT^ ANACAAATATTTNTTGGGTC^TTNGNTNTTTGGGNNAACCCNCCCCCCCCCNAAANCCNA AAANNNNNNGCGTTTTTGNGNNGNNCNTGGTGA TNTTGNTTAGGAATGAANANATGGGNNCTCCCCTTNNNNNNTTTTGGCCATNANCCCCTCT AACCTTI ΓCCTCCCCCNCTCCCCCCCCCCTTTTTTNCCCCCCNTTT^^

CCCCTCNTCTCOSINCCCCCTNAAGGGGGNGTTANTAAN^

CCNATTGGNTNNCTGGNGNAGGGNCCCAATGTTANGGNNNATCTTTTTAAGGGGNANGCT

TNGNNNANNANTGTAAATATAAAAGNTTGNACCNTCNNTTTNNTTAACAAATTTT^ TNATATTTTTTNNCCCCCCCCCCCCCCCCCCCNNTTATTTTTNAAATTANAπ^ ATCTN1SINTTNTTNNGGNGGGANCCTAG

NANANNANAANCACNNANTANCCTCTTNTGGTTTNNTCCTTTCATTTTNANCTANTTGNCT

NNCAATNTTTTNCANTNTATTGTACCANCNT TTNAAAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGNACGAGGCCGGNTTCGGATCGNGAGTNCGNGCCGNAGCGNGCACCGC GGNCCGNANCTATGGCGGNNGTNGTCCGANTAGTTTATTGNGGCGCTTGAGGCTACAAGN CCAATTATNTTCAGCTNAAGAANAAGTTAGAANATGAGTTCCCTANCCGNTTGGACNTCT GCNGAGAGGGGACTNCCCAGGNNACCGGCTTCTTTGAAGTGTNCGTANCGGNAAAGCTG

NTTCACTCCAAGAAGGGAGGCGATGNNTACNGGGNCACGGAAAGCAGGTTNCTGAGCTG GTGCCCGCNATCAANNCCGTTTTGACTCAGGCTNGATNTGGCCTAAAGGNATAAACCAGT AATNGTGGCCCAACCCCTNTNGGNAGAC(^TTATTGACANGAAGGACTGAANTGTCTTTT GGACNC^TGGTCCTTCCCTGATGTTTTGCCGGC(^CCGTTNGGAACAAANATGGACACCC CTGNNCTTTTCCTTTGCATACCGGTGTCCATGAANACCCCCGACGCTGNGCCTGGTGGCCT

TNCCCANANATAATTTGC^TTGATTTTCAACCGGCCCTTCCCCCAATGTTTNCCTTTTAATC CTGGGGGGGGCTNGGGGGGGGCCTACTNTAAGCTTTCNTTTTCAAAGGGGAANCTTGAAA GGATNATCNGGAATGAATGAGTCTTNAAAATTTAANCAGNGGATGGNAACAACTTTACAA ANCCAATNAAANGGGGGATGAAGGTTAACCCAAAAAAAAAAAAAAAAAAAAAATTTNG GGGGGGGGGGCCCCGGNNCCCCAAATTNCCCCTTTAAGGGNGGGNNNNNNNAAAANNNN

NNNNNNNτ>lNNNMSINNNNNNNNN^ NNNNNNNNNNN

TTNNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGCCGTGACAAAATGTGCTCCATGGTCAAAAAGTGGCAGACCATGATCGAAGCT CACGTTGATGTCAAGACTACCGATGGTTACTTGCTTCGTCTGTTCTGTGTGGGTTTTACTAA AAAGCGCAACAATCAGATTCGGAAGACCTCTTACGCCCAGCACCAGCAGGTGCGCCAGAT CCGCAAGAAGATGATGGAAATCATGACCCGAGAGGTGCAGACAAATGACTTGAAAGAGG TGGTCAATAAATTGATTCCAGATAGCATTGGAAAAGACATAGAAAAGGCTTGCCAATCTA

TTTATCCACTCCATGATGTCTTCGTTAGAAAAGTAAAAATGCTGAAGAAGCCCAAATTTGA ATTGGGAAAACTCATGGAGCTACATGGTGAAGGTAGTAGTTCTGGAAAAGCTACTGGGGA TGAGACAGGTGCTAAAGTTGAACGAGCTGATGGATACGAGCCACCAGTCCAAGAATCGGT TTAAAATGCAGACTCTTAATGGTGACAAATAAAAGATCTTATTTGTGGTNNNANAANNNN NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNAANNGGGGGGGGGGGGGCCCCCCCCCNTTTTTTTTTTTT^ NNANAAANNNNNNNNNNNNNNNNNNNNNNNrø NNNNNNNNNN NNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNT^NΠNΠSΠSINNNNN^

NNNNNNNNNNNNNNNNN

TTGANCAANNCTGGAGCTCCCCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGACNTNACNACGAGGGCTNCATGGTCANNANNCGGCANACCATGATNGANGCN

CACGTNGNTGTCAAGACTACCGNTGGATACTTGNTTCNTCTGTNCTGGGTGGGNTTTACTA AAAAGCGCAACCTNATATTCNGAAGACCTCTTACGCCCAGCACCNCCAGGTGCTCCAGAT CCNCATGAAGATGATGGNAATCATGACCCNATAGGTGCATGACAAGTGACTTGAAAGAG GTGGTCANTACATTGATTCCATGATAGCATNGGAAAAGACATAGAACAGGCTTGCCANTN TATTTATNCACTCCATGATGNCTTGGTTNNAAAAGTANAAATGCTGAAGAAGCCCAAATT

TGAATNGNGAAAACTCATGGAGCTACATGGAGAAGGTATGNAGTTCTGGAAAAGCTACTG GGGATGAGACAGGTGCTAAAGTTGAACCGAGCTGATGGATACGANCCACCNNTCCNNGA TTCGGTTTAAAATGCAGACTCTTATGGGNGACAAATAACAAGATCTTATTTGGGGTGGTN AAAGNTTNGCTCCTATCTANAACAGTTTTAAAAAATGTACCANGNGNAATTTTATAGAAT TTTGAAAGTTTACATTTTNTTTTTT^

ATTGTTNTNAAAGTGGCCTTTTCCCAAACCTNGCT^ ACNTTAAAAAAAAAAAAATNCCTTTTNTTTTTTAAGNNNTN^ T^WTNT(^TTTNNTNTGNGGGGGGGGNCCC<_^^ GNNTTCCTTTNNAAAANNCNNNNNNNNTNNNNNNNTTN^ TTNTTNTCNNNTCTNNCNNNNCN

NNCHNGCNNAACCANTCTTrmX^TN^^ CNCCCCCCT(^CNTAANCTTCCACANATAANGGNNNANCNTANNNTrCGTr<3NNCCCTTT GNAGNCCCACTGGAGCTCCNCGCGGNGCCGGCCGCTCTACAACTANTGGATCCCCCGNAC

TGCAGGNAATTCGGCACGAGGGAGTTTTTTTTTTNTTTTTNCCCCCCCC

CTNCCCNTAANNACTTTTNTTNAN^

TNCTACNANCCCNNANTCCNCCCANTCATCTNAANCCTTCTNTCTCTTNCATNNATATNNT NTCTACACCCANAAAANCAAATN]WCCTNANGA(_OT^

NCAANNNNNTNCTNNNNNTS[ANNNNAAAGGATANTANNAAACANANAN^ CTTTCNNTTTNT(_MSINGGTNTANNTAAANCCATTACTGANATCGANTCTCTTANTNTACNG GTNNGANT<-^ANTANTαsπ ATNAANTC^ NNNTAGTANNNATNCTNNTNOSfNNNN(^WGNTNTGTNCNNNNAANN CANNNNGTT (^CCNTCCTANGO>nNCTNANCNNANNNTNTTCNNA^

C(-N(^CNATNNCTNTANCCCCCTCTαSfNNAANCAGTNGNCNNGNNNTNTAAAATATANAA CCCATCNNNA(^A(^TNTTNCTANTACNACNGGNACTCANGGTαSlNNATNANCATTAAAT CCGNTANTNNNOWCGNCNr^NNAOWANTATTNN>WCTTATCCCAANATNCNCGGAN^ NNTTAGNTNNNNTTNTNTNANCGCTNTATCNCTNCCGNTACTαsrAAGTCNTNNACTGCAT NTAGGATCNNTCGNGNNCNNTCTNTOvINCCACCGTNNANNTNNCNNNCTTCATANGTGNG

CGANTACGAGNNNCCGNATNNNATCNCNCNTATANNATATACTTCGCTTTCNNCATCGCN NCTNTCANNNTCNACAGTCTACCCAGNCTGCATGNCGTCTTACTCTGTNCNTCTCNCACAC [NTNNCCGNNANNNT INNNACATNACTCT]SINNNGCTATATCACACCGTNNNANGNACNT ATNCNANATNTCCNGANANTNCACNCCTAATANTCNACNGNGATNTATCAATCGTCATNC TCTCNCATNTNTANTCTGATTANTTNNTCNCTCACACNNATNNTAGCANTCTTNNAGAGTN

T INNNTNACMSfTNACACNANCCTCNCTATAGTNTTNGATACTCCTTNAGα^CGNNNCCTC TTNACNCTCGACGCGTCGTATANNTCACNNCNANTCNNATGNNNNACATGTCACGTCTCA TCNNACACATTTGCGGNATNATCTCCAANANATNCNNAACGTCNTSINCNATTTATNTCTNC GCN

AAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GCACTCGCTCGCAGTTCGCTCCGCGCCCTCTGCAACCATGTCTGACAAACCCGATATGGCT GAGATTGAGAAGTTCGATAAGTCGAAATTGAAGAAAACGGAAACGCAAGAGAAAAATCC ACTGCCTTCGAAAGAAACGATTGAACAGGAGAAGCAAGCAGGCGAGTCGTAATGAAGCG

TGCGCCGCCAGTATGCACTGTACATTCCACAAGCATTGCCTTCTTATTTTACTTCTTTTAGC TGTTTAACTTTGTAAGATGCAAAGAGGTTGGATCGAGTTTAAATGACTGTGCTACCCCTTT TCACATCAAAGAATGGAGAACTACTGACAACGTAGGCCGCGCCTGCCTCTCCCATCTGCTT GTGTGGCTGGCAGGGAAGGAAAAGAACTTGCATGTTGGTGAAGGAGGAAGCTGGGTGGG ACGACAGTGAAATCTAGAGTAAAAAGCTGGTCCAAGGTGTTCTGCGGGCTGTAAAATGCA

GTTTAATCAGAAGTGCCATTTTTTTTTGTTGGTCAAATGATTTTAATTATTGGA TTTTTTTATTATGCAAAATAAAAAGTTTTAAAACCTGAAAAAAAAAAAAAAAAAACCTNG GGGGGGGGGCCCGGNCCCCATTTCCCCTTTTNGGGGGGGNNNNNNNNAANNNNNNN^

NN Tsπsπ iNTsπsπstNNNN NN^ NNNNNNNNNNNNNNNNNNTSINNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNN

GTGNAAGGGGGGNNCGGGTGTNGGCCTTTCTTNNNTNGANNCNATCNGGAGCTNCACCNC GGGGGCGGCCGCTCTAGCAACTAGCGNATCCCCCGGGCTGCTAGGCNTGNANCAGATNTT GANTNTTATTCATCTTTTTCNNNACCCTNCTTTTNTTNNTCTGGN^

AANNACNANGTTTTATNATAANNNCANGANCTGATTACCATNTATANANANCNGCAACN GCGANACNCC(^TTGANGAAACAACGAGGCGACCAACAAGaSfGATTTNCCCGGTTATTAT

TNNCNCCTGCGNNTTANTAAGGNTTTNTCCTANCTCGGGNNCGCCCNTNTNAGNAACNTA TTCNCCCAGCCCTANANATGNNCCCATANTNNTNATACTCGACTTAACCNNAGNANNTCT NCGTNNTGTTNACGNNGNNNANACNNANTGAACTNCCTGTNAACANTGGNGNTCNAAGN NOSrATAGN(^TGAATTNATCTCNCCACNTGCCTNNNNGNGGNCANNNCNNTNAANCNGπ TNTATATNTNGATATG(^GTTTGCATNTCTNNCNAAANNNGGANTCNTANNANACCGCNT

ACNTANNGNGCTATCTACCCCCNANGTCNTNTCNCNNCCAAGACNNTNNNTCTANTCTAC TCGAANGNATNCCCNANGANCGNTTATCMSrACTCTCCNCCTTGNCGTNNTCNCTGATTCA CGNCATNANTTNCNNNTANNTCTCNCCCANCTACCAAATGNTGNATAGCATTTTNTTTNNG CACNNATTTCACTNGTACCCNNNATNTGGANNCTNNCCC(^CCTTCCCANCTNATTGCCCN ATATACCGTCATCCNTNNTAATTCGNNNNACACCNACANNAGCNCCNNGTTCTTNNCNAC _TNT(^_{τττττττcrøACI}^

GCCNGNGCTTNNNCCTNTATNANTCNTNTANNCCTTCNNTGNACGGCGGGCGNNTNTTAG

NNTCTTCNNACTNGNTNAGTNNAAGCTNATTAGCTNNTNNTAACCGATNNANNACTATNT NATTNTAC^TCTGTCNNCNTCGACTATNCACANTGCTACHNNGCNTAACTCNTTNNTATAN

TGNNGNTTCHlSfAGCTAGNCTCTAACTTNTGATGTANCGNGTNNNNANCGCTCNNGGGTGA

TTTTACNCANATCNNNAANTATTCTCTCGCGATNANNNCNNGTTCNCGTNNGNNNGATNT GNNTCTTANAGNCTNATNAGCACTNTCTAAANNTNANACNTGANCG

GCCTATNNGGAGCTNCATCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCANNTGTNNAGGGGGCACAGCAAGAGCCGCCCCCAGGAACCACAGACCCAGTAGA GACCTGGCTGTCCCCTTGGGCATGGCCTCTCTGCCCTCTGGACCTGTCTTCCATCAGGAGA AACCACTGAGATGGGTCCCCTTCCCCCAATGCCACATACCACAAGGACAGGGCTCATAGG CCCTCTTCCTTGCCAATCTGATTCAGGGCCTCGGGTGGAGTGAGGAAGGGAGGCCCCACC

CCCCCAGCCTTCAGCGTCAAGCTGGGCAGACCCAGGAGGTGTGCCCCCGATGAGGACCCA GCTGCGGTGACCCCTCTGCCCCCTTCTACCTCGCCATCAGCTCCCTACCCAGCTTATCAGCT GGGTCTCACCTGCCACCCTCTTGCCTGGCCAGTGGGAAGTGCAGGGAGATGGGAGGAGGA CCTAGCACACAAGTAGGCCCTCAATAAAAGCTGGCTGGTGTTGCACTTTAAAAAAAAAAA AAAAAAANTAANGGGGGGGCCCGGNCCCCANTTNCNCCNTNAAGGGGNGTNCGAATAAC

ATTTGNTNNTNTTNTNNNNNTNNNTTCGTNNNNACCNAT^ NNNTSπSTTNGNNTCTACTTCTCTO^ TTNNNTGNTTNTTNNTNTITNNNGNGNTCTNNGN^ (^TNNCNCNTAGNGGANCCCTTGNCCNNNGGNNTNTAATTCANNTATTNCTNTNNCNNN^ ANT<^TCTTNNNNNNNCTTCN^

NCNCTTNNCTNNNTNTCTCNNNTTTTNNNNGNGNNCNGNTCATT^ NACGTGTCGNGGGTGCCC

GCCTATNNGGAGCTNCATCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGCANNTGTNNAGGGGGCACAGCAAGAGCCGCCCCCAGGAACCACAGACCCAGTAGA GACCTGGCTGTCCCCTTGGGCATGGCCTCTCTGCCCTCTGGACCTGTCTTCCATCAGGAGA AACCACTGAGATGGGTCCCCTTCCCCCAATGCCACATACCACAAGGACAGGGCTCATAGG CCCTCTTCCTTGCCAATCTGATTCAGGGCCTCGGGTGGAGTGAGGAAGGGAGGCCCCACC CCCCCAGCCTTCAGCGTCAAGCTGGGCAGACCCAGGAGGTGTGCCCCCGATGAGGACCCA

GCTGCGGTGACCCCTCTGCCCCCTTCTACCTCGCCATCAGCTCCCTACCCAGCTTATCAGCT GGGTCTCACCTGCCACCCTCTTGCCTGGCCAGTGGGAAGTGCAGGGAGATGGGAGGAGGA CCTAGCACACAAGTAGGCCCTCAATAAAAGCTGGCTGGTGTTGCACTTTAAAAAAAAAAA AAAAAAANTAANGGGGGGGCCCGGNCCCCANTTNCNCCNTNAAGGGGNGTNCGAATAAC ATTTGNTNNTNTTNTNNNNNT πsπSfTTCGTNNNNACC^

NNTSINNTNGNNTCTACTTCTCTOT

TTNNNTGNTTNTTNNTNTTTNNNGNGNTCTNNGNTNTTATN^ røTNN<^CNTAGNGGANCCCTTGNC04^ A T(^TCTT>JNNNNNNCTT<^C^ NOSfCTTNNCTNNNTNTCTCNNNTTTTNNNNGNGNNC^

NACGTGTCGNGGGTGCCC

TTGANAANATCTGGAGCTCCACCGCGGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGTNACGTTGGTGCTCCCGNACCCAAAGGTGCTCGNGGC

AGNNCTNGTCCCCCTGGNGCTACTGGTTTCCCAGGTGCTGCTGGCCGAGTCGGTCCCCCCG GCCCCTCTGGAAATGCTGGACCCCCTGGCCCTCCTGGCCCTGCTGGCAAAGAAGGCAGCA AANGCCCCCGCGNNGAGACTGGCCCCGCTGGGCGTNCCGGTGAAGTCGANCCCCCTGNTC CCCCTGGCCCCGCTGNTGAGAAAGGAGCCCATGNNGCTGACGGACCTTGCTTGAANTTCT TGGCACTCCTGGACCTCAAGGTTTTGCTGAACAGCGTGGNGTGGNCGNCCTTTCTTGGTNA

AAAAGGAAAAAGAGGCTTCCCTTGGTCNTTCCTGGGCCCCTTTGGTGAAACCCGCCAAAC NANGTNCTTTTTGAACCAGNNGGAGAAACGTNGCCCCCCTTGGTNCCAATGGGCCCCCCC TTGGATTGGCTTGGAACCCCCCTTGGATAANNCTTGGACCGTTAAGGGAACTTCCTTGGTG NTTTAAANGAATTNCCCTTGGAAAAAAATGGTTNTTTTTTNNCCCCCCA^ NNNGGGNGAAAAACCGNTCCTTTGTTGNAACOSINCT^

GGGGGGCCCCNGGGCαSfTTNTTGGNACTTNTCNGGCNCCCNCCCCCCCCCCCCCCCCCCCC

NGAAACCGGGCCTGNTTGGTNCCTTNTTTNGANCCCANTTGGGCCCCGTTNGGTTNNCCCC

NGGNCCCCCCCTTNGAAANCCCAAGGCCCCCCTNNGGNNANAAAGGGTTNNNAANAANG

CAAANAANGGCCTAACNAAGGCNTTTNNGGGNTCNCCCGG^

GGGTTCCCCCCGGCCTTTNCGGGTTTTTTTGGG(^CCCCCCCCCCCCCCCCCCCCCCTTT

ANAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGNNNGGTCTGGGNGNCNNGTGCTCCAAGGAAGTAGCCACTGCCATCCGNGGGGCCATC

ATCCTGGCTAAGNTGTCCATCGTCCCTGTGCGAAGAGGCTACTGGGGGAACAAGATCGGT NAGCCCNACANNGNTCCTT^^NNANGGGACTGGCCGATGGANATCNTTNCTGNTGCGCCTC ATCCCTGCCCCCAGAGGCACTGGCATCGTCTCCGNCCCTGTGCCCAAAAAANTGNTNNTG ATGNNCGGATTNGNCGACTGNTNCNCTTCTGCCAGGNGCTGNACTGCNNCCCTGNGNAAN TTCANCNANGCCACTTTTGATGC(^TTTNCAAGACCTATNGNTACCTNACCCCTNACCTNT

GNAAAGAGACGGTNTTCACCAAGNCTCCATATCANGAATTCACTGACCATCTTGNGAAGA CCCACACCAGAGTCTCCGTGCAGAGGACACAAGCCCCAGNTGTAACCNCCANATAATTTT ATAAAGGGAATAATAANGTGANTGAAACCNTGTGNNNGNAGTGNNGNNTNNANGTTGGG GGGGGGCCCNGCCCATTTTGA(^CTNAGGGGGGCTTNAAAAANNNNNNGCNNANAGGAA CTGTNGCCACGGGTGCGGGGTGNGNCNTGAACCCTGNCANCATNCCTTTNGAGGTGGNAN

CNCCANCNCATNGGNAANCCTTTTATT^TTNNCAAAAACCCCCTTCTNGCCNGAAANNGG GTTTTAATTNNTNCCCNCCGGACANGCCNTTTNCGGGGAACCAAAAATTTOStNGAA NAAANNNNGGNNTNGGNNTNAANAAANNTTNTTTTTTTT^ AANTNNGGGGGGGNCN

NNACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGATGGCTTTAGGGATGGAGATGCTGCTTGAGGAGCCCGCAGAT AAGTTTTTCTATTAAAAAAGATAGGCGTTAGTGTATTTCTTTAGGGATTATAAGTAGTGAA AATACGGAGATACTGCTTTGCATTAAGTTCTTAGATAAATTTTAGGGAAAATATGAAGACT

TAAAGAGTAGTTGGAGAAAGGAAGAGGGAAGAAAAAAGATAATTTTAGAACCTGAGGGA GGTTAAGAGCTGAAATTTTTTCATGGAGTGAAAAATTTAAAAGAATTGATGAGCTAGGAC TGCAATGTCTGGATTTTTTTTTTAAAGCCTTAACTTGAAGGGCAACCTTTTACCπ AAAACGTTGGGTTACGTAAATCGAACCTAANCGTTTTAAAAGGTTGAGTTGTAGGTGATT AAAATACTACAAAGGCCATCTTAANATTTACCTGAAGGNGGTTTCAGAAATAATGCCTTC

ANATTCNCGGCGCAGTAAAAATGGCGTCATTTTGAAGCCTGCTTGATACTAAGGCTTTGTT TGGCTAAAGTTGACCGGAAATATTAGGAATGGGAGGGAAAGAAAATTGGAAAGTTTGAA GTGGGAAAATTTCGGAAAAACAGAAGTNCCGGGAAGGNGGAANAAAAAACCTTGGAGAA GAATTNGGAGGTTCCCCGTTTTAAAAAAAAAAAACCTGGGCTTACGGGAACCCGGNCCCA AAAANAACCTTCGNNAAAAAAAATTGGGCNAAATTTCCCCAGNGGGCCTTCAANANCTCA

NGGGGTTTCCCAAGNCNGGGCCCAAANAAAAAATNGGCNGGGTTN^ NNNNNNNNNNNNNNNNNNNNNNNNNTSIN^ NCNNCCCCN

TNNANCAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGAGAAGGGTTAATTTTCCTGAGTTTGGATAGTTTTGAG CCCTTGACTTTAATTTCATTGCCACCACTCAAATCTCTTAGCACATTGCTTAGGATTAAGG ATCCAAAAATGCTATCTAGAGAGTTGCTAGTGGTGTTGAACAATGCAAGTTTTTATTTAAA AGAGCTCTGCACTGCCATTTATGAAAGCCTCTTTATGATGTTTGTTTTGTTGTCATTTTTGT

TCTTTACACCAAGAAATTGTATGTACAAATATGCAGAGAACATATATTGCCTCTGCTTTTA TCAGGGCGCTCACCCCTGGTACTTCGTATATAAAATGTATTAAAACTGGGATTTGTTACCA GTTGCTGTATTTTGTATATAGAATTTTTAT^^ AAAAATAAATTAAAAAATTTAAATCCACATCCATGGTACACCTTTCTTGCCTGAAATGTAA AGAATCCATTTGTCACCAGGGATCCAGAACCCCATCAATTGTGAAGTTTGCTCTATCTAGA

ACAGTTTAAAAATGTCAGTGTATTITATAGATTTGAAGTTAACATTCTTATTTTCAAGANA ATTTATGAACATTGTAGAAATGTATAAATGCATTTNCCAACTGGCTTAAACATTGGANTTT TATAGACTTAAAAAAAAATNCTATGTTTAAGTNN JN^ CGGGGGGGGGGCCCGGACCCCAATTNCCCTTTTAGGGGGGGNNNNTAANNNNNNNlSπsπ^

NNNTSINNNNNNNNNNNNNNNNNNNNN^

AAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GAATTCGGCACGAGGGAGNTTTTTTTTTTTTTTT^^ TTTTTNAANGNNGCOSINNNCCCAANT^ TCNNNNNCGNNNNTTTNTTNGATCTNCCTAAAANAAANNGGGNACCTTNGGGNCCNTT^ CCAAAGGGNAAGGGGGTTNCASTAAAANCCCTTNGGGNAAANNAAAGGGTGNTTTTNTAA

NCCNCCCCNNANGGGGNGNNACNNANNATNGATGCCCCAGGACACAGAGACTTCATCAA AAACATGATTACAGGCACATCCCAGGCTGACTGTGCTGTCCTGATCGTTGCTGCTGGTGTT GGTGAATTTGAAGCCGGTATCTCCAAGAACGGGCAGACCCGTGAGCATGCCCTTTTGGCT TACACCCTGGGTGTGAAACAACTAATTGNTGGCGTTAACAAAATGGATTCCACTGANCCC CCTATANCCAGAAGAGATACNAANAAATTGNTAAGGAAGNCANCACCTATATTAANAAA

ATTGGCTACAACCCCGACNCAGNANCATTNGNGCCAATTTCTGGCTGGAATGGNGACAAC ATGCTANAACCAANGCTAATATGCCNTGGNNCAAGGGANGGAAAGNCCCCCNNNGGACN GNANGCOSΠSΠSRGGACCNCCCTGCTGGAACNNTGGNATNGNNTNNGCCNCNANTNNNCCCA CTNGANAACCCTTGCGNNNGNCNNTCCAGGANGNNNNTAAAANNGGNGGNNNNGGNCN NGNCCCNGNGGNNΠNINNNN^^

NNNNNNNTS NNNNNN

NCAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCGCCATGATCGCCTTTGTCCGCCTGCCCAGCCTCAAGGTCTCCTGCCTGCTTCTCT

CAGGGCTTCTCATCTACGATGTCTTTTGGGTGTTTTTCTCCGCCTACATCTTTAATAGCAAC GTCATGGTGAAGGTGGCCACGCAGCCGGCTGACAATCCCCTTGACGTCCTATCCCGGAAA CTCCACCTGGGGCCCAACGTTGGGCGCGANGTCCCGCGCCTATCTCTGNCTGGAAAACTG GTCTTNCCTANCTNCACGGGCAGCCACTTNTNTATGTTGGGCATNGGANACATCGTGATGC CTGGACTCCTGNTGNGCTTTGNCCTGCGTTATGACAACTACNAGAAGCAAGCCAGCGGTG

ACTCCTGCGGTGCCTNCGGACCCGCCAACATNTNCGGGCGCATGCAGAAGGNTTCCTACT TTCATTGCACCCTCATTGGATACTTTGGAGGNCTGCTCACTGCGACTGTGGGCGTCTTGAA TTCACCGANCANANCCAANCCTGGCCTTCTCTATTTGGTGCCATTTACNCTTATTGCCACT CCTCACGAAAGGCCTATTTAAAGGGNGACACTACGGCGAATGTGGGGGCTTGAGCCATTT NCACTCCAANATCCACCAAGATCCCCGATTCCTGGGAAGTATGATGGATNACAGCGGGGC

GANOSRAGAAANGGGGCCTCTCANATC(^TTTRCTGTTNAAACGTGGTGGGNTTTGTTTNCC TTCTTAAAAGNTGGNCCCTGGNTAACTTCCGGAANANGCANCCTGTGTTAAAAGAACTTG CCGTGGTGCCCCNNAATTTTNCCATTNTTANGGAAAGCGAAGGTGGCTNGGAAACCCCTG CNNGGNTTNCCCTTTCTTNTTACCTNGCCGGCCGGNAAAAGGGGNNAGCCNCCCTCCNTC G

TTNAGCNANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCC NGGCTTGNNGGNAGNTGTCCAGGGGGCANAGAAGAACCCGCCCCNAGGAANCNNAAANC (^ANAAAAANCTGGNTNGNCCCTTGGGCNTNGGCNTTTTNGCCTTTGGANCTNGCTTNCA

TTAAGNAAAACCNNTNNAAAGGGNNCCCTTTCCCCAATGNCNCATNCCANAAGGNCCGG GNTTATNAGCCCTTTTTCTTNGCAATNTGANTCAAGGCCTTNGGTGGANTGANGAAAGGA NGGCCCACCCCCCCAGCCTTTAACGTNAAGCTGTGCACACACCANGAGGTGTGCGCCCCG ATNAGAGACACACACTGTGGNGACACCTCTGTNCCCTTTTANNTCTCCATANAGATCNCTA NNCAGNTTATANGNTGGGTCTCACNTGNCACCCTCTTNNCTGNGCACNGGGAAATGCNCG

GAGATGGGAGGAGGACCTATCACACANTAGGCCCTCAATAAAANCTGGNTGGTGGTGCA CTTTAAAAAAAAAAAAAAAAAACTOINGGGGGGGCCNGGGNNCCAATTTNCCTTTAAGG NGGGGGTTTAAANNNNNNNNNNNTNNNNNNNNNNNNNNN^ NNNN N l^ N NΗ NN ^ NNNTSINNNNNNNNNNfNNNN^

NNNNNNNNNNNNNN NNNNNNNNNN^ NNNNNNNNΪ>INNNNNNNNNN NNNNNrINNNNNNNNNNNNNNNTNNNNNN^ NNNNNNNNNNNNNCN TTNAGCNANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCC NGGCTTGNNGGNAGNTGTCCAGGGGGCANAGAAGAACCCGCCCCNAGGAANCNNAAANC (^ANAAAAANCTGGNTNGNCCCTTGGGCNTNGGCNTTTTNGCCTTTGGANCTNGCTTNCA

GAGATGGGAGGAGGACCTATCACACANTAGGCCCTCAATAAAANCTGGNTGGTGGTGCA CTTTAAAAAAAAAAAAAAAAAACTCNNGGGGGGGCCNGGGNNCCAATTTNCCTTTAAGG NGGGGGTTTAAANNNNNNININNN^ NNNNNNNNNNNNNNτ>[NNNNNNNNTSπ^ NNNNNNNNNlSπStNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNT^MISπSlNNNrø NNNNNNNNNNNNNNNNNTSπSINNTNNNNN^ NNNNNNNNNNNNNCN

TTGANAANNTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGANAGCGGANAAGCCCAGCCGANAACTTTCANGGACNC TGTGAAGCAGCTCCAGCCGAGATGTGCNAGGAGGAGGACAGCACCGNCTTGGTGTGTGAC AATGGCTCTGGGCTCTGTAAGGCCGGCTTTGCGGGGGATGATNCTCCCAGGCCTGTTTTCC

CATCTATCGTGGAACGTCCTCGACNTCAGGGAGTGATGGTGGGAATGGGACANAANGACA GCTACTTGGGTGATGAANCACAAAGCAAAAGAGGAATCCTGACCCTGAAGTACCCGATAG AGCACGGGCATCATCACCAACTGGGGACGACATGGAAAAGATCTGGCACCACTCTTTTTT ACAATGAGCCTTTGNGGTGGNCCCTGAANAAGCATCCCAACCNTTNTAACCGAAGGCGCC CCTTGACCCCCAAGGCCAACCCGGGAGAAAATGACCCAGATNATGGTTTGAGACTTTCAA

TGTCCCANCCATGTATGTGGCTATTCANGCGGNGCTTGCCCCTNTACGCCTTTTGGACGCA

CAAATTGGCNNTTGNGCCTGGACTTTTGAANATGGGGTCACCCACAACGTGCCCCTTCTTT

TAAGGGCTACCCCCCTTGCCCCCCαsrCCATTATTGCCGTTTGGGACCCTGGCTTGGCCCGA

' AANTNTCANCCCGNCTACCCTTATTGAAAAANTNCTTGACCCGAACCGANGGCTTTTTTCT TTTNNGAACCCCCCCNTNGACCGNTGAAAAATTGGTCCCGGGGACCTTTAAAGGGGAAAA

AACTTGNGGCTTACCNTAANCCCCCTGGGA WTTTTTAAAAANTGANANAGGGGCCNCTT TGNCCGNATTNNTTTTTTOSlTTTCCαSfTNTNAAAAAAAANTTN

GGNCCCGGGTGATTNNCCNTTTTNGGAAAAAGAACGGTTTTCCCCTTTTCCCCTTTANAA^ CCNT

TTNANCAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGGCCATGGGCCGCGTGATTCGTGGGCAGAGGAAGGGCGC CGGCTCCGTGTTCCGCGCACATGTGAAGCACAGAAAAGGCGCCGCGCGCCTACGCGCCGT GGATTTCGCCGAGCGACACGGATATATCAAGGGCATCGTGAAGGACATCATCCACGACCC

GGGCCGCGGAGCGCCCCTTGCCAAAGTGGTTTTCCGGGATCCGTACCGTTTTAAGAAGCG GACAGAGCTGTTCATCGCTGCTGAGGGCATCCACACCGGCCAGTTTGTGTACTGCGGCAA GAAGGCCCAGCTCAACATCGGCAACGTGCTCCCGGTGGGCACCATGCCTGAGGGCACCAT CGTGTGTTGTCTGGAGGANAAGCCTGGTGACCGAGGCAAGCTGCAAGAGCCTNTGGAAAC TATGCCACAGTCATNTNCCACAACCCTTGANACAAANAAAACGCGAGTGAAGCTGCCTTC

NGGCTCCAAAAAGGTCATNTTCTTTTGCCAACANAACTGTGGTCGTTGTGGTGGCTGGAN GTGGC<^CATTGACAAANCCATTNTGAAGGCCGGCCGNGCCTCCCCAAGNTTAAGGGNAA AAGGAACTTGGTGGNCNCNGGTGCNGGGNGNGGNCATNAAACCTTGGNAGCσSfTTCCTTT GGNNGGGGNAAC(^CAACCAATTNGGGAAANCCNTTTT^ TTGGCCGGNAAANNGGGNNTTANTTTTTTNCCCCCNGGAAAGGGCCNTTTT(^GGG

CCAAAAATTTGCCCGGGGAAAAGGGNAAACTTNGGGGTTNGGGGTTNAANNAAAAGCTT TTTTTTTTTTTTTCNAAAAAAAAAAAAAAAAAAAA^ TTNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGGGAGACGCGAGCAGCTGTGTCTCCGGCAACTGAGGTAGAGGTTTAACTGTC GTCCCGGCGGAGCAAGTCAAGACACATCTACGGCCGTCTGGGCCAGTGTTGGGTCTCCGT AGCCTGTAAAGATGGTGTTGCTCACGATGATCGCCCGAGTGGCGGACGGGCTCCCGTTGG CCGCCTCGATGCAGGAGGACGAACAGTCTGGCCGGGACCTTCAACAGTACCAGAGTCAGG

CTAAGCAGCTCTTTCGAAAGTTGAATGAACAGTCCCCTACCAGATGCACCTTGGAAGCTG GTGCCATGACTTTTCATTACATTATTGAACAAGGAGTATGTTATTTGGTTCTGTGTGAAGC TGCCTTCCCTAAGAAGCTGGCTTTTGCCTACCTAGAAGATTTACACTCAGAATTTGATGAA CAGCATGGGAAGAAGGTGCCAACTGTGTCTAGACCCTACTCCTTTATTGAGTTTGATACCT ACATTCAGAAAACCAAGAAGCTTTACATTGACAGTCGTGCTCGGAGAAACCTAGGCTTCA

TCAACACTGAACTGCAAGATGTGCAGAAGAATCATGGTGGCGAATATTTGAAGAAGTGTT ACAGCGGGGAAGAAACCGCTTTTCAAGCANTGGATTTCGAAGGCTAACAATTTTGTCCAG TCTGGTNCCAAAAAAATACCCGNCAGGGATGCCAAAGTACNTTGAAACATGCCGNTTCAC NTTACCNCCCAAACNTTGGCAGCAGGAAGCTGGGANTTTTTTCATCATGGGTAAAAAAGG GGATGNGNCCCCTTNTTGGGGGGCNTGGGNAANTAATGNAATNCCCGTCCCCTGGGCAAG

GGGANAAACCTTNAAAACCCCGGNGNGGGGTNTNNTTTTAAGGNAAACTTGANCCCCCCA AAAAATTNTNTNTT

NNCAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGATTATAAGTTACAATGGAAGGCAACTTCATGAATTAGATGGG CTACTAATTCAATGTAATGAACCACACACCAAAATAAACAGTAGAAGGTGCTTGTAATTG TTGAGAGAAATTAACAAAGTAGAACCATGTTGTTGTTCAGTCGCTAAGTAGTGTCCAACTC TTTGCAACCCCATGGGCTGAAACACATCAGGCTCCTCTGTCCTCCACTATCTCCTGGAGTT TGCTTAAATTCATGTCTATTGAGTTAGTGATGCCATCTAACCATCTCATCCTCTGTTGTCCC

CTTCTCCTTTTGCATTCAGTCTTTCACAGCATCAGGGTCTTTTCCAGTGAGTAGGCTCTTTG CATCGGGTGGCCAAAGTATTGGAGCTTCAGCAGAAACATTCGATCCTTAAACTGAGTACT GTCTTAGTTTCCTCGGGCTGCCTTAACAAAGCACTACATACTTTAAACCAACATACTACAT ACGTTAAACCAACAGGCAGGGTTGTTCCCTTCAGAGGGCCATGAGGGGGAATCTGTCCCA NGCCTCTCTCCTAACTTCTCTTGGTCTCCTGGTCATCTTTGACTGGCCNTGGCATGTAAATA

TCTCACTCCAGNGCTCTGNCTTNCTTTGACATTCTCTCAAGTTTCTTCACATAAGTCTACCT GNCATGCATGGTCTNTTTTTGGGGGNCCAGNTTTCTTTCCTTTTTATAAAGGACTNCAATC CTGGTNGGATGAAGGCCNCCCCCTTTTGANCCATCATGGACTTGGATACCCTTGGGAAAA GGGCCGGANTTTTCCNAAAAAAAAANCCCCCTT1TTGANGGTTNTTGGGGGGTTAAGGNC AC

NNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGGTTGGCTTCGTATCGTGGGCTCGTCCGCTGTTACCCACCTACCA

GAGCCCTTCCCCGCGGGGCGGGACCTCGTAACGGCCAACTCCTTTCCAGCTGAAGAAACA CTTAAGTTCTGGAAATAGCGACCCAGTATCATGGCTGGCAGCCCTAATGAAGATTCAGAA GGAAGCCGAATTACTTACGTGAAAGGAGACCTATTTGCATGTCCCCAAACAGACTCTTTA GTGCATTGTATCAGTGAGGACTGTCGAATGGGCGCTGGGATAGCTGTCCTCTTCAAGAAG AAATTTGGAGGAGTGCAGGAACTGTTGAATCAACAGAAAAAGTCTGGAGAAGTGGCTGTT

CTGAAGAGAGATGGGCGATATATATATTACCTGATTACAAAGAAAAGGGCTTCACACAAG CCAACTTATGAAAACTTACGGAAGAGTTTAGAGGCTATGAAGTCCCATTGTCTGAAGAAT GGAGTCACCCGACCTTTCCATGCCAAGGATCGGATGTGGTCTTGATCGTCTGCAATGGGA AAATTTATCCGCAATAATTGAGGAGGTCTTTGAGGCAACAGACATCAGAATTACTGNGTA CACACTCTGAACAGAAGAGCATTTTGGATGTGTCTACCTTCTGCATCACCTGGGCCACAGG

ACTGGAGCAAACTGACCTTAAAATGGTCAGAGGACCCGTTTCTTGNGAAGTAGTCTGGGT TACANGNCNAACCTGGGTTGCTGTATTCNTCANGATTGAATGGGACTTNTGGGAGGAGGG GTTCTTGTGCTTAGGAATTTTTNTTTTTCAGGAANGGAANGGGGANGGGACCAATNTTGG GCCNAGGACCCCTTTTTGCTNGGGAANGCCTTGGGAATGGGTTTGGGTTGCCCTAGGGGG GANCNTTGGGTTTTCCTGNTNNT

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGCTGATTTTTTTTTTTTTTTTTNGT^ NTTNANAAANNANNNCCNGNCNNGNCCNTO^

NTAATNTGGATNNNTTAACCGTTNNAANGGNCNTTTAAAACTNTCCNTAAANTT(^ GGAAAAAGGGANTTTGNNANTNTGNGNGNGCCNGGGNCAAANGGNAAAAAACCAAAAA AAAANCCCCAGGGNAANGGGAAATCC(^TAA(^TNAAANCATTTNNNAAAAGGGCTT1W

NNNGCCAANAANAAAGGGAGTNTTTTNAANTAACC^TTCCCAGTTNANGGACCAGCCCA GNATTCCTCATTNCAAGCCCTCNATNAGNCCCTGNGGGACCCAAGGGGCAAAACCTGTGT TCGGAAAAGGTTTαSfTAGGTTGGGAAAGGCCCAAAGCATTTTTNCCCCCCATTCCAGNNG GGTTAGGACCCCCCCCCCAATNTTAACAATGGNCCCANCCCGTTTTTTTCCGGGNATGCCC CNNCCNCNCCCNAAATGANCCTGCACCGGGGGGGGCCCGGGNCCCCAATTCNCCCTTAAA

GGGGAGGN INNNTNAAANNNNNNNN^ NNNNNNNlSINNNN NNNNNNr^NNNNN^ NNNNNTSINNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNN^ NlSπSlNNTSINNNNNNNNNNNNTSINNN^

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGTCCCGTATGTGGCCCAAGAGATCCAGGAGGAAATCGATGA ACTGCTTCAAGAACAGCGAGCCGACATGGACCAGTACGGCAGCATCAGCCATGGCATCGT

GGAGGTCGACCCGATGCTCACCCCAGAAGAGCGTCACCTGAGCAAGATGCAGAACCATG GCTACGAAAACCCAACCTACAAATACCTGGAGCAGATGCAGATTTAAGCGGGGGAAGCG CANCGCCAGTGGAGGGAGGNTGGGCGGGCAGCAGACGTCCAGAGGTCTGGATGGACGAT GGACCGACAGTGACTTCCAGAGGAGTTCCTCGACACTCAGATCTCCTGGAACATTAAGAC TATNAAGTACTACTGTAGAGTCACAATTTCCATTCTTTTAAATGGGCGAAAAAATGTTAAT

ATAACAATATATGATATATAAACCTTAAATGAACAAATGATCTATTGCAGAAAAAAAAAA ANNANANAAANNNAANAAAAAAAAAAAAAAANNTNNNGGGGGGGGGGGNGGGGNCCC AANTNCCCNNAATGGGGGGGGGTNTTANANNNNNTSINNNNNNNNNNNNNN^ NNNNlSfNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNN NNNNr>πSINNNNN^

NNNNNNNNNNNNNNNNNNNNNNNN^ C

TNAGNCCTATAGTGANGTNGNATTNCAGTGGCGGNCCGCTCTAGAACTAGTGGGATCCCC

CGGCNTGNAGNANTTCGGCACGAGGNTGANTC^TATTNNTTNTTNCGCTTTCTACGGCCN

NNGANNCCNTTTTNNNANTNNNTC(^CCCNNCTGGCAAATNNCNGGGNAAACCTπ ATTTNTTTTNNTTNGGNTNGGCCCTTNAGGCTNGTNANGGNNTTNNA

NNTTNCTTGGGNGNAANNGGNNNAATGCANCTNTTNNCGGNGAAGGGGNTAAACGGNAC TNACGC(^AAAANCATGNAAACGNGGCGTCTCNCTCCTCTANTNTNNAAACAATTNTTCT NNAGGNCTNTTISINTTTTTNTCACAAAA^ NT1WAAGATTTTNTGNGCCCANAANANGANNGGGNNTTTTTATAANNGCNNTACCTGTGT GTGGAAGACCCCCCNANANGNCTTTTTTTTTAAAGNAGGTGNNTNGGANCNCNTNTNTGG

AGANACGANNGAGGAAAAACNANGNTTCCNCAAAAAGNTTTTTNTTTNTCGNNGNAANA

CANCATGGAANCNTCC(^AGGTNNGGGGGGGNα^ACCCCCαsπSlNCACTTGGTTTTATTT TTANAAGNGNNGCTATGANNNNCANNTANNGNTNTCGTTTTNTNTNNAACNCNAATCTπ

NAATTNT(^CNCCCCNNNNCTNGCWTCTGGTCNNTTANTCTANCCTCATNNCCTTCCNGNT

NNANTNNNTT(^CCCANTNNANTTTNCCGACCTANNNAAANAANNTCTNTNNCCπ AGAAANGNTAATTTCCTTONtNNANN^CT^ NCCG

TNAGNCCTATAGTGANGTNGNATTNCAGTGGCGGNCCGCTCTAGAACTAGTGGGATCCCC CGGCNTGNAGNANTTCGGCACGAGGNTGANT(^TATTNNTTNTTNCGCTTTCTACGGCCN

NNGA]SINC(^TTTTNTS!NANTNNNTCαsrCCCNNCTGGCAAATNNCN ATTTNTTTTNNTTNGGNTNGGCCCTTN^

NNTTNCTTGGGNGNAANNGGININNAATGCANCT^TTNNCGGNGAAGGGGNTAAACGGNAC TNACGCCNAAAANCATGNAAACGNGGCCTCTCNCTCCTCTANTNTNNAAACAATTNTTCT NNAGGNCTNTTNNTTTTTNTCACAAAAAGGGGTNTN^ NTNNAAGATTTTNTGNGCCCANAANANGANNGGGNNTTTTTATAANNGCNNTACCTGTGT

GTGGAAGACCCCCC NANGNCTTTTTTTTTAAAGNAGGTC^

AGANACGANNGAGGAAAAACNANGNTTCCNCAAAAAGNTTTTTNTTTNTCGNNGNAANA

TCTCCCTTTTNTACTCTTTTNCCCC^

TTTTTTTANAAANATACCNCNCCTCTTTT^ CANCATGGAANCNTCC(^AGGTNNGGGGGGGNCMNACCCCCαSINNCACTTGGTTTTATTT

TTANAAGNGNNGCTATGANlSπsπ CANNTANNGNTO^

NAATTNTCNCNCCCOWNNCTNGC^

NNANTNNNTT(^CCCANTNNANTTTNCCGACCTANNNAAANAANNTCTNTNNCCTTC^

AGAAANGNTAATTTCCTTCNNNANNCNCTGAAT^^ NCCG

TTGANNAACCGNTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCTCACCATCAACCCCCAAAGCTGAAGTTCTATTTAAA CTATTCCCTGAACACTATTAATATAGTTCCATAAATACAAAGAGCCTTATCAGTATTAAAT

TTATCAAAAATCCCAATAACTCAACACAGAATTTGCACCCTAACCAAATATTACAAACAC CACTAGCTAACATAACACGCCCATACACAGACCACAGAATGAATTACCTACGCAGGGGGT AATGTACATAACATTAATGTAATAANGACATAATATGTATATAGTACATTAAATTATATGC CCCATGCATATAAGCAGGTNCATGACCTCTATGGCGGTNCATAATACATATAATTATNGAT NGTNCATAGTACATTATGTCAAATTCATTCTGGATAGAATATCTATAATATATTCCTTACC

ATTANATCACGANCTTATTTACCTTGCCGGGGGAAACCANCACCCGGNTAGGCAGGGATC CTTNTTNTCGNTCCGGGCCCATAAACCGGGGGGGTGGTTATNTAATGGAATTTTACCAGGC ATNTNGGTTNTTTNTTCAGGGCCATCTNATOT AAAACATTTCGANGGACTAATGGGTTAATCAGCCCTGCCTTCACACATAACTGGGGCGGG CATAACATTTGGGANTTTTTTTAATTTNGGGGGGANGCTTGGACTTCAGNNTTGGGCCGGN

AAAAGGGCCCTGGACCCNGGAACATTTTTTTGGGNCCTGGGNCTTAAACTGGNNNTTTTG GGNCCCCCCCCTTTATGGGNTAGCCCTGGGNO^TTTNCNGNCNATNGGGNCCCNGGGACT TNAANTTTTTTTTTTTITm^ CCC

TTGANCACAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAAT^^N^SINNA(^ANG(^CTNCCCNGANNCAANTGCAGAGNCISI ACCATTGGTC AATGNATNCNAATGAANGCTGTGNATCANCTCATGTNCAANTCCAAGAGCACCACATTGN TNATNAANCGCGCTGGTCTATCTAAACCAGACTGGNCCNATNAAAANCGGACTTAACATG

CCAACCANTTTTTTAAGCNGCNTANTTNANTTGAANACNTCNCTACTGTAATGCTCGNCCA ATGANGNTNTTACCTNGGTATGCGTCTGANACCCTCGNATCTTNTACTTNGGGGNAAANC NNATATCNTNTNNAAAGNGGGGGGNCNCCTANCCCTTCATCCCANTTGGGGCGAAGAAN AAAGNCAGANCCTGANGATGAGCTGCTGTTTTGATTTTTTTNATAGTTCCCCANAANGGA GCCTACTGGGAAAGTGGAAATCNAAAAAGAAAAGGGCCAAACCCCCTGTCTTGCAAAAG

TCTCGGACATCCAGCGTCAATTNTTGTNAACCCCAGTGTAACCNCCNTTCAAAGCCGTTNA AANAAAATTCCTTTTTGGGAGCCCAAAAGCCCTTGCCTTTTTNTTGATTCANNATTC CCNTNGAAACCCNCGAAANAATTTTTNAAAAGGGAAAAATNTNTTATTCAAAANGCTT^ CTGGGACCTGGNCCCCCAANCCNATGCCCTTAACCGATGAATGGGCNGATTCACAATTGA AACTTNGNTTAACCTTTTGGCCTGGGAGAAACCCATTTNTTGGNGNAAATTGAAAGTT^

NAAATTTAAAATTCAAGNAAAATGGGCC(^TTTTTCCTTTCAAAGGGTCCCAAGGGAAAC TTCAAGAAANAAATTTANCCAAAGCCCGGGNGCCTGGAATTTTGGNAAAATTGGGANTTN TTTGNCCCTTTTCAAANAATTNGGATCNAAANAANTCTTAGAAACNNT

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGGAGAATTCAAGTGTGATCCTCATGAGGCCACATGCTATGAC GATGGGAAGACTTACCACGTGGGAGAACAGTGGCAGAAGGAATATCTTGGTGCCATTTGC TCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGACAACTGCCGCAGACCTGGG GCTGAACCCGGTAACGAAGGCTCCACTGCCCACTCCTACAACCAGTATTCCCAGAGATAC CATCAGAGAACAAACACTAATGTCAACTGCCCAATTGAGTGCTTCATGCCTTTGGATGTAC AGGCTGACAGAGAAGATTCCCGAGAGTAATATTTCCAACCCAGAGAAACAAGCGTGGATC TCTGCCAAGGTCCATCCAAACTGGAGTGGTGTTCGCAGACCCCATGTTAGTGTGTTCCTTT CTTAAGCCCTTTGCTCTGGAGTAACTTCTNCAGCTTCAGCTCAACTCACAGCTTCTCCAAG

CATCACCCTGGGAGTGTTTTCAGACTTTTCTCATACATGGGAGCAGTAGGTTATCTATTCTT CAAAATATTCCATGCCAATCAGTATTTTAAAATGAAGTGATTCTNACTTGNGAATTTGGAT TGGGAATCCATAGGGAAACACATGCCCCCAACCAAGATACCNAAATGTCNTTGAAATGAT ATTANCCAAAAATTTTAAGTANGGAAAGGTANCCTGAACACCTTTTGGNTTCCACTTAAA CTGGACTGGGCCCCGCNAATANTGNAAGGAAACAGCATGNGCCCTTTGGANCTGGGGGAT

TCAAAAACAAGNCCrøGGTACTTC^TTTTTTC AAAAAAAATTNTTTTTTNTTACCCGGNAATTTNAAANAANTTTTT^

ANCANNGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGNANGATCAANCNANTCCTGGCCAAGAAACAAAAGCAGAATCGTCCCATTCNNGA ATGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATTGGA GAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGTCTTAACATG TAGACCACTTTTTTAAGCAGCCAGATCACAATGAAAACATCACTACTGTAATGCTTGGCCC ATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCAATAAATATAAAACGTTGCAAAAA

AAAAAAAAAAAAOSfTGGGGGGGGNCCCGGNCCCNNNTTCNCCNNNNTGGGGNTCNTNNN NNACACANAGNAC CCATGTCCTNNTCθNπSfGTNTTNGNTNNTG(^TCNANTNTTGNTCGN TTAGNCCTTTCTNCTTNNTTTTTANTTNCCANTNNTGGTGTNANNNG NNGNTNTNNNATCCGCCNAATCAACACNAGNTCO^ACNNTTTCGGGNANTNNTTNNCTAT CCCNANNTCGAACTTAACAGTCAAGNTTTTTNGNTCTTNNANCCANATANTTTCNNNTATT

NNNTTTNNGGCNNTNTGGGTNTNTNCTNNTNNACNNNACATTNGGNCπ NTNT(^TNGGGATTTCCTTTTTGNNCTAσSfTGATAANNCAAATNCTATNNNGCAπ^ CTNACANCNGTGTNNNCT(- TCATGANATTT^ TTτWTNTNCGTCANAAT]NINCGTNTC^^ CCTNNTTTGTACCTCCCTCTGGNCCGGCNTNAACNACα^TTGNAANAGTTCNTGTNNNTAC

NTTTCTCTTCTACGTCANCNTTANCTAGTTCNCTTTTNGTTTNTCTTANTCTACNNTNCNTC CC

GNTGGGNCGNANATNNNCNCANATNTSINTTTCCC^CCCCNNNNCCCTTTTCCCTCCTTCNCC

CAAACTCCCCC(^CCTATGGNGNNNGAAAGTNATATTTTCNCNTNCTTGAGAAANACTGG AGCTCCACGCGGTGGCGGCCGCTCTANAACTAGTNTCATCCCCCGNACTGCACGATTTNC GACATCCTTNNNNTTTTITCTTAATNCCT^ ANNGGCNTANTTAAAAANNTACGTCAt-MSrANCTTACTATTTTTTCAANNAGNNTGAAATT CC WTTNNNTANNTNTTNTTATNNCTANTNGNTCTTCANNNTAATNNAAN^

ATCNTNTNANTTTCANTAAGAACTANNTNTAGATCATATTNTNCAANNTGNNTTNTATNTC GANNANTTATNATNTCNCAAANNNTNTGNNNTTANTGATNTTCNATTTTTTNACTATCCAA AANTNNNCGCNTNAAANATNNCNCAATAGTAGNCNNTNGGNCCANCNGTNATNATTTTCT ATCANCANTTACTCTANNNAGTCTAATTNTTANCTTNTGGTNANNTNATTTACNTATNGNN ATCAANC WATTAAANTTNTNGTACTANTCATATNNNGTGNANTTTNTTCNTNANTCGATN

NATTATAGNTCNNCGCANAGGNNATTTTTNTNGAACANNCATTATATANNNNAANGNATA ANTANNTNNGNNAGAAGNNTTTNNNNNGCTCTTNTTCTNNGCAANTGNNTANNT^ CCTAACT(^ACNTCAGNTANCTTTTCNCNNNNCCNTCANNAGTNNCGNNGTNAANCANNC ANCNGGCNTNATTATNCNATATGTNTNNNATCANCGATGCGO fNNNAGNNTACTGTNCAN CGTNNTGTATNNNOWTNGNNNTCNTANTNNGNANCTCAGCATATTAGCTNANGTTTNTC

TGNAANCGCCTNGCNTTANNTNTNTA(. ^

GCCTNAGCNNTNTNNGNNTGCNCGCCNAATNCAGANTNTCGNATNTGCGNACNTNCNNN GGANNATATACTTANNTGCACNGATATCTNATATATCTNCTGATNNGTCANNNANTNCGA TCATAANTNTCGNATCATNNNNTANNTANNCTGATATGCNGCNNTNNTGCGCACACNNTG AGACGNNANNTAAGANNNNGTGNNATANTATNACATTTTNACAANGNGAANNGACACNC

NACNNNTNTNGNTNANNTAATGATGATACGTNTNANAGATAGANCGANATATNNCAGNG TCTGNANGTG(DNATANTNCNCGANTCNATCACTTACTCATTTANGCTTNTNNTGNTCNCGA GATNANNCNNTNATANATNTACNTGTCTNAAGANAANTTCNTACNCNNGTCANATATNTC TANTGANNANNTGTTACGATAGTNTACGTACGANOS1NAGTNTCNCTCNNANAGNCANNAC ATATACTATNACGACNANTCTAGACNANATACGNCANAGNNANGTGANTAGNANTNNCN TANTCTNTNNTCNCTACATTAATANNNATAGTGAGACGNGTNNCTTNATANNCTAATACN NTNNGAGTNNTNNAGATATATGCTNAATCTCTCGCC

NNCAANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCAGCTGCAGCGCCTCTCGTCTTGTAGGCTCTCCTAGCTATCGCCTTTTCGCTTCCG GAAACATGGCCTCCGGTGTGGCTGTCTCTGATGGGGTCATCAAAGTGTTCAACGACATGA AAGTGCGTAAGTCGTCGACACCAGAGGAAGTGAAGAAGCGCAAGAAGGCGGTGCTCTTC TGCCTGAGTGAGGACAAGAAGAATATCATCCTGGAGGAGGGCAAGGAGATCCTGGTGGG

TGACGTGGGCCAGACGGTAGACGACCCCTATGCCACCTTTGTCAAGATGCTGCCAGACAA GGACTGCCGCTACGCCCTCTATGATGCAACCTACGAGACCAAGGAGAGCAAGAAGGAGG ACCTGGTGTTCATCTTCTGGGCCCCTGAGTGTGCACCCCTTAAGAGCAAAATGATCTATGC CAGCTCCAAGGACGCCATCAAGAAGAAGCTGACGGGGATCAAGCATGAATTACAAGCAA ACTGCTACGANGAGGTCAAAGACCGCTTGCACCCTTGCAGAAAAGCTGGGGGGCAGCGCT

TGTCATCTCCTGGANGGCAAGCCTTTGTGAGCCCCTTCACCCCTGNCTGGACATCTGGCAG CCCCAGACCTGNCCACGGGGGTTGCANGCTTGCCCCTTCTGCCANACCGGAGGGCTGGGG GAATCCCNCAGGGGGANGGCANTCCTTTNNCCCANTTGCCAAAGCCCCCCCGACCCCTGG ACNTTNTTTTCCTTNACCCTTGANGTT^ TTTGGGGTGGAAAAAAAACAAATTNCCCCCCCAGGAANCCCTNTTTGGGGGGGGCCTTTT

TTTTTTTAAAAAAACCCCAANNCCCTGCCGGNNCTNCCCTTTNCCAGNNNGGNA

GCCCTATNNGGAGCNGCATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTTTCATGAAGATGGAGAATGCTGNGTNTATGATGAACCATTACTGAAGNGNCTN

GGNGCTGCCAAGCATTAGGTNGGGANNCACAAAGTTTGCTCCTGGTTCCAGGGCACGATG CATAATNAAGCAACAATCTTCCTTTGGGAGAACCTATTCACTCCCTTCTTATTGCAGCCGG NCNCTATCTNCANGGNATACTTGNACTTTNTGATGCANCATGANCAATTAANGCGAGCAA AGCNCCCCTTTTTNCTGNTGCGTGGCAAGTNACAACNNTNGANTTTGGCCTTGATAAAAA NTTCAGGTTTTGAAAACAAGATGTCTTGCTCCTTTTCCAAATCCCACGGNATAAATCCCAG

TNTTAAACNCTGCATTCTANTACTGNTGNTGAGANATACAATACATGTTTTCCTAGTNCAT ATAATσSfTTGGGTTNCTATATATACATATNNTATAATTNTATGCTGATGCCCGGATTTTTC ATANNATACCTGCATTTTACTGTNAAACATCAAGNCCCCTCTGAGTTGTTTTTANNANANA TTTNCNGCNNTTGCGGTTAAAAATTCNCCTCGGNTNTGAAAANTTCCATGGGTCCNCTCCT AN(^ANNCAANNT(^TCACTTTGGNAATTGAAACTANTATTNNCTCAAA<3WGNATCTCT

TACCTCTTGGNCCTGGGGGTTTTAANNTNACACCTCNAANGGCTTTCCTNNTAGGNTTNCN NANNNGCTANATTOWTTNTCAANCTNTGCTT^

NCNGAANTACAANTTTGGGACCCGNATANTCA(-^TCANNGNNCTTNTTGATNNNNNNNAA NGGCCTG1WGCTTTTTGTNTNGTGN>JNN^ NTNTACANTNNCTNGNNCTNCTTTCNNTATAANCCCTTNNGTNNNCCANGNCNNCANAAN

ACCG

GNNGGGCCGGNNNATNNNTTATNTTTNTNNTATNTTITTTN^ CTTANT WGGGGNTCNNCNGNGNNTTCAATGGNGGGNGCGGNGGGCCNNCAGNNTTNNG

CCCNCGGGAGTCGCATNACANGGNGGCCGCTCTNCANTATGNNTTCCTCCGNNCTGCANC ATCNGCNCNNNCNCCTCNTTCNTTNCNTCNCCNG<^TCNNCTNNGTCNCAAGGGGGANTT

ANTNTANNNAANAGTNTCNNNNTTGNCAACTTATNTNNTNTTATCCNTNATATNGNAGGC TNNANTOSfGNATCTNGAGANNCGGGCTNTCCNNNCNTGCTTTAANTTNTTT(^ANNGN^ NCANGANNNCNCANTCTATNCTNNANNAATNTNNNATGTCNCNNNANNTTNTCGCACGA

NTCNTCGTTNNTNCACAGNNTNTGTTNTTCTNGNNCNCCGTNNNCTCTTTCNN^ TNCCTCAGTTTTNTTNNNNC^CCNNA(^ATTNTCTCNATCNCANTNCNT^^ TCGTTNNNANANATCNNTNCNTTNNNNTNTTTNCTACNTCTNCTN CTANTCNNNTAANNNTTCGNNTTNACCTN^ CM^GATCNCGTTNCCCMWTNCTCNNGTCNA^

NTATNTCTTTNGANCGC(^TNNGNATACCATTNATTATAATACGNANATNNNTCNCNCAC GNGNNCCCANTNTCTCTNNCNNTSINGGNTTNTGNTNANTNTCCCAAATCNCαsπsrC^ NT^WATGGNC(^Cσ INNTANNNCCANNAGNNNNCGATTAGNACANNNGNTNTNGGACGN TClNINATCNATNNTNTNCTGNNGt- rAGNC^^ NTNTCGNNNTAATCGNTGTNTGTTNANNNTGNNCTCTANTNGNCNGGCNNTNGGTNNNCT CTANTGAGTCCACGNTNNNNTCTNACTCTGTTGNNACGNGATNTTGCTCNANCTNACNGC TCNTNTATN(^CNCNTGTNNNGCNNNAGTNATCNTCCTATTGTNTGTTACTCCTT^ CTACANNGTTTNGCTNTNNNTGCTTGACCNCTNTAGACCGNGCTTCCNNTNATCCTCATGN GATGTNTNNCNTGNTANNWCCTC^TCCGCTNTTNNCNTNTCNANTGATANGAGTCTNNN

NTNATNCGCNNTGTNNANGTANTANNATACNCNNANCTCNATGNCACTCCAGTGATGNAN GTNNTATANNTAGTCTNNGTCATCGTANCANTCHNNATGGTACNNANTCTCTNGNGTNGN CGCGTNGTATGTGGNNGCNNTNTTCNATGACGNTNTANAGCAGTANNGNTACACNTNTAT AGTCCGTNTNAC^AATCTCTNGNTTNANCNTNTATTCNCNNCNGCTCNCTCCCGN

GNNGGGCCGGNNNATNNNTTATNTTTNTN^

CTTANTNNGGGGNTCNNαSTGNGNNTTCAATGGNGGGNGCGGNGGGCCNNCAGNNTTNNG

CCCNCGGGAGTCGCATNACANGGNGGCCGCTCTNCANTATGNNTTCCTCCGNNCTGCANC ATCNGCNCNNNCNCCTCNTTCNTTNCNTCNC(^G(^TCNNCTNNGTCNCAAGGGGGANTT

ANTNTANNNAANAGTNTCNNNNTTGNCAACTTATNTNNTNTTATCCNTNATATNGNAGGC TNNANTCNGNATCTNGAGANNCGGGCTNTCCNNN(-^TGCTTTAANTTNTTTCNANN NCANGANNNCNCANTCTATNCTNNANNAATNTNNNATGTOSrCNNNANNTTNTCGCACGA NTCNTCGTTNNTNCACAGNNTNTGTTNTTCm^ TNCCTCAGTTTTNTTNNNNrø^

TCGTT JNNANANATCNNTN<^TTNNNNTNTTTNCTACNTCTNCTNANANTTATTT^ CTANTCNNNTAANNNTTCGNNTTNACCTNT^ αSfNGATCNCGTTNCCOSINNTNCTCaSlNGTCNANCCNACTCATTGCCTCTATNNTCNNTANT^ NTATNTCTTTNGANCGC(^TO SfGNATACCATTNATTATAATACGNANATNNNT<^ GNGNNCCCANTNTCTCTNNCNNNNGGNTTNTGNTNANTNTCCCAAATCNCCNNCNGACCC

NTNNATGGNCCNCCNNNTANNNCCANNAGNNNNCGATTAGNACANNNGNTNTNGGACGN TCNNATCNAT INTNTNCTGNNGCNTAGNCNATTTTCNANNTGNTGCTNGCGNTANTGCNC NTNTCGNNNTAATCGNTGTNTGTTNANNNTGNNCTCTANTNGNCNGGOSfNTNGGTNNNCT CTANTGAGTCCACGNTNNNNTCTNACTCTGTTGNNACGNGATNTTGCTCNANCTNACNGC TCNTNTATNCNCNCNTGTNNNGCNNNAGTNATαsfTCCTATTGTNTGTTACTCCTTNTTAGN

CTACANNGTTTNGCTNTNNNTGCTTGACCNCTNTAGACCGNGCTTCCNNTNATCCTCATGN GATGTNTNNCNTGNTANN(^CCTCNTCCGCTNTTNNCNTNTCNANTGATANGAGTCTNNN NTNATNCGCNNTGTNNANGTANTANNATACNCNNANCTCNATGNCACTCCAGTGATGNAN GTNNTATANNTAGTCTNNGTCATCGTANCANTCNNNATGGTACNNANTCTCTNGNGTNGN CGCGTNGTATGTGGNNGCNNTNTTCNATGACGNTNTANAGCAGTANNGNTACACNTNTAT

AGTCCGTNTNACNAATCTCTNGNTTNANCNTNTATTCNCNNCNGCTCNCTCCCGN

TTNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCAGCAACCGTCGCGATGTTGATGCCTAAGAAGAACCGGA

TTGCCATTTATGAACTCCTTTTTAAGGAGGGGGTGATGGTGGCCAAGAAGGATGTCCACAT GCCCAAGCACCCGGAGCTAGCAGACAAGAATGTGCCCAATCTTCACGTCATGAAAGCCAT GCAGTCTCTCAAGTCACGAGGCTACGTGAAGGAACAGTTTGCCTGGAGACATTTCTACTG GTACCTCACCAACGAGGGCATCCAGTATCTCCGTGATTACCTCCACCTGCCCCCTGAGATC GTGCCCGCCACCCTGCGCCGNAGCCGTCCTGAGACTGGNCCGGCCAAGGCCCAAAGGTCT

GGAAGGAAAGCGACTTGCAANACTCATTCGAAGGGGAAGCCGACAGAAAACACCTTACA GACGAAGCGCCGTGCCCCCTGGTGCCGACAAGAAGGCCGANGNCGGGGCTTGGTCAACA ACTTGAATTCAAGTTTAAAGGCGGATTTGGTCGTGGACGTGGTCAACCNNCTTANTGAAA TTGAAANGGAATGGTTTTGTGTTGAATAAACCTGTTACCCGAAGAAAAAAAAAAAAAAAA ANGGGGGGNCCCGGNNCCCAAATT(^CCCTTTAGGGGNGNNNNNTNAANAANNNNNNNN

NNNNNNNNNTWNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN

TTGANACAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCMSiNATNAAGαSπSINTCCTCCCAAGAANCAAAAGCAGAATCGTCCCATTNCTCAN TGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATTGGAG AAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGGTCTTAACATG TAGACCACTTTTTTAAGCAGNCAGATCACAATGAAAACATCACTACTGTAATGCTTGGCCC ATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCAATAAATATAAAACGTTGCAAAAA AAAAAAAAAAAANNNTGGGGGGGGCCNNGGCCCCNNTTNCCCCTTNTNGGGGNGGNNNT

NANACTNCGGGAACCTTNACTAACCANATCCANGCCGCATTCANGGAGCCAANGTTTTTG GTGGGCACCGATNCCAGGGCTGACCACCAACCCCTTACGGGNAGCCTNTTACNTGAACCT GCAACCATTGNCCTTNTGCAANACGGGCTNTNCTNTGNGCTACGTGGANATTGNCATTCC NTGCAACAACAANGGGAGNGCNCTNANTGGGTCTNGAGTGGNGGATGCNTCCCCGGGAA GTCCTGNGCATGCTTGGCACCCNTTTTCCGANAAGCNCCNCGNGGGGAGGTCNTGCCCGG

ACCTTTTACTTTTTACANAAAAlTSrC rNNGGGNGAATTNGAAAAGGGAANNA^ NMSfNNTTTTANAAAGNNNTNTGArW^

NTTTCCAOSfTTCAAANTT CGGGTNNTTNNNNCCTTTAGGGGGGNNAAAATTGN^ AANGGGNTTNNAANGNNGCCTTTTαstNGTNCCCTTTTANNNNNT^^ CTTNGANGGCCTCC

TTTGAANACAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGANTTNNGCACNAGGNNTTTANCTAAAAANCNNNNTNNTCNGGGCANNAG GGGGGGNNNCATNCTGACNATNGCNCNCGCNCNACNNACCCGGGNANTNNGGNCNANCN

NTNNCNGNCATGAGGCTNNCACACCNAACNNANATTCACANNTNCCCCATNATTGNNGAC NCCNGCNTNCNGNCATGANAANNNGCTGCCNTCCCAATGACNNTNNTTACNTCACNATAT ACNTGGTATNTNCGANCAN(^CTTNANTTTTTAANTCCACTT }NNCCAAGGGNANACTAC CANNCTTNAAATCTNTTANCα TNGGGNAGGGCNAAATNCCCTGNCAGNCNANNANTANN AACNGGANTTTNCNANGGNNCGANCNNGGACGNAACCTTTTNGGGACCTTGCCNNANGG

CCANNTNTNGGCCCCATGANTGCCCTIStNNTNNNNNAGGNNNACCCTCTTNNAANTNGNNG TNIWGNrWATN^]m a^>ϊNTN<^AC^^

NCAAACNANGATNTTCTNTCTNCCTTGAAANGGANNAAAAAANAANTTTCΓΓATTTAACC

ACCATTAAAAANNNNTCGNGGTNGGNTCANNNCANCTNCCCCTNCTCNNAAAANACC^TT TANTCCCTTNNGNNTGNANNANANGNNTN^

TNACTNNATNTCCCCNNCGNTCT(^CCTNNNTCNTNNNTTNTTCCCCACCNGNTTNCCGAA

AAACCTNTTNCCCAANANCTANNGTTT(^CCANNNTCCWNTNCACTCCTATTANNTNNAT

RWTNTNNGTTNNCTTNATNTCTCCTCANNA^

CTCCANTATNCCGC(3NTCTACTNCTTCCTNACTTCNATCAANAATTACNNTNNNNTNCTCC GTCGTTNNCTGTTTANTCNTACCTNTACTAOWCANNNGTTAATNTTGTNCCC

NTCTTCTNCTCATANNCN

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGCAGCAACCGTCGCGATGTTGATGCCTAAGAAGAACCGGATTGC

CATTTATGAACTCCTTTTTAAGGAGGGGGTGATGGTGGCCAAGAAGGATGTCCACATGCC CAAGCACCCGGAGCTAGCAGACAAGAATGTGCCCAATCTTCACGTCATGAAAGCCATGCA GTCTCTCAAGTCACGAGGCTACGTGAAGGAACAGTTTGCCTGGAGACATTTCTACTGGTAC CTCACCAACGAGGGCATCCAGTATCTCCGTGATTACCTCCACCTGCCCCCTGAGATCGTGC CCGCCACCCTGCGCCGCAGCCGTCCTGAGACTGGCCGGCCAAGGCCCAAAGGTCTGGAGG

GAGAGCGACCTGCAAGACTCACTCGAGGGGAAGCCGACAGAGACACCTACAGACGAAGC GCCGTGCCCCCTGGTGCCGACAAGAAGGCCGAGGCCGGGGCTGGGTCAGCAACTGAATTC CAGTTTAAAGGCGGATTTGGTCGTGGACGTGGTCAGCCACCTTAGTGAAGTTGAAAGGGA TTGTTTTTGTGTTGAATAAACCTGTAAACAGAAGAAAAAAAAAAAAAAAAAAGGGGGGG CCCGGNNCCAAATT(^CCNTAAAGGGGGNNNNNTAAAAANNN^

NNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNTSfNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNTNNNNNtNN^

AAAACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GCTCCTGGTGAGCAAGGTCCTTCCGGAGCCTCTGGTCCTGCTGGTCCCCGCGGTCCCCCTG GCTCTGCTGGTTCTCCCGGCAAAGATGGACTCAATGGTCTCCCAGGCCCCATCGGTCCCCC TGGGCCTCGAGGTCGCACTGGTGATGCTGGTCCTGCTGGTCCTCCCGGCCCTCCTGGACCC CCTGGTCCCCCAGGTCCTCCCAGCGGCGGCTACGACTTGAGCTTCCTGCCCCAGCCACCTC AAGAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATGATGCCAATGTGGTCCGTG ACCGTGACCTCGAGGTGGACACCACCCTCAAGAGCCTGAGCCAGCAGATCGAGAACATCC GGAGCCCTGAAGGCAGCCGCAAGAACCCCGCCCGCACCTGCCGTGACCTCAAGATGTGCC

ACTCTGACTGGAAGAGCGGAGAATACTGGATTGACCCCAACCAAGGCTGCAACCTGGATG CCATTAAGGTCTTCTGCAACATGGAAACCGGTGAGACCTGTGTATACCCCACTCAGCCCA GCGTGGCCCAGAAGAACTGGTATATCAGCAAGAACCCCAAGGAAAAGAGGCACGTCTGG TACGGCGAAGAGCATGACCGGCGGATTCCAGTTCGAGTATGGCGGGCCAGGGGTTCCGAT CCTTGCCGATGTGGCCATNCAGCTGAATTTCTTGCGCCTGATGTCCACCGANGCCTTCCAA

NAAATCACCTACCACTGGAAAGAACAGCGNGGNCTAATGGACCAAANCANACTGGCAAC CTTCAAAAAGGCCTTGTTCTTCANGGCTTCCAACGAAAATCGAAAATCCGGGCCGANGGG AAAAAGCCGGTTTACCTTACAGGGTACCCTACCANGGGTGGCCAAANCAACCCGGAACCC TGGGGGCCAAAAAGNGATTGGAATACCNA

TTTGAGNCCTTANANGNGNNGTCGGTATTAACAAGGGGANGGGCGCGNTATAGNAACTA

GGTGGTATCCCCCGGGCNTNGCAGGNATNCANATT(-^WTGAGGGNNTTNNCTTGAGCCCT

GTAGGGGAGNNCNCGTNNCTNGGGGGOS1NNTCNNATGANCCTAGTACNNANACNNNTCT NTTNAGNNNATNTTTIΗNNGTGNCNNTANANNNGANNNGATTGCNTNGAGCG

GGNTNNCTTNNATNCGGGNATNNGNAG(^ATTGTNTGGTTAGTTGNNTANAGGNNNTATN NTGANNATCCNNTGNNNNNGNGGAANGCNNAGGGNGNNNTNCGANNGTNCTNTNNNTGN ACGATNTGACM^NNTTNNTCGATNNNANAATN^ TNGTGNNNNGCNANTAAACNNNCNANNNTANNNANNGATTCCNANATNNNCCTNAANNC G TTNANCNNNGTN NNNAATNANCNTGQNNNC^

GNGCAGCNTATGNACAATANTGGNTANNTNNANTNNNATTAGNNCNACTGATACNGNAA NTNTNTNNCCTNOTNC TTT^

NNGGNGTNTCGTGTANTNNAANGTNNNNAGGGNNGGGNNNTGNNANNTNNGAANGNGG ANANNTATGATGCNCMNπsfAGTACTTNTGGAACTTCATTNNGNANGGGGNTNNGTNTCTGN ANGNGNCNNNNGNTGCATGCNTANTNTNNNANCCNNTTATNGCNCTCTGTNTGNGGNGNT

NNNTGGANNTTNGGNNNGTTTANNNNGNNTO^

NTNTGNGCTNT(_^GGATGTTGNNTTTGANCAGTNNGTANATNANNGGNTNANTANGNATN ANATNNNNTAGGACGGTNATGGGAACOSfNGGTANATNNTTTTGTNNNGT^^ NGGTGNAGNNANTANATCTANAANCGAGGAAC(^AOSfTTNNANNNGNNNNNTTCGNNNT GNAGTANTAGNCGGCGCNGNNNTAAGTTANCTTGCNACGATNCGTTGTGTCNCNCNCGAN

ATANGCGNTTNNACGTTNCTGNTOSlNNCACGTNGCTCNNNTNAGNGTTCGNTNN(-^ NAGGANTNTGNACGTNTNCGAGNGAACNNACATCGTCGNATGGCNTNNAATGNGNGCGT ATTNGNCGTNGNNGACNANTGACGCANCNATANNNCTNTNNGTACGTANGTAAGTCNNA NNNNTNCTNNNTGCG

NCAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGCTTGAAGAAGAAGTACCCAATGGCCAAGTACCTGTGTGTGTTGCTAATTGTGGCT

GGAGTGGCCCTTTTCATGTACAAACCCAAAAAAGTAGTCGGGATAGAAGAACACACAATT GGCTATGGAGAGCTGCTCCTGCTCTTGTCTCTAACCCTCGATGGACTGACCGGTGTTTCCC

AGGACCACATGCGAGCTCACTACCAAACAGGCTCCAACCACATGATGCTGAACATCAACC TTTGGTCGACACTGNTGNTGGGAGCTGGAATCCTGNTCACCGGGGAGCTCTGGGAGTTCTT GAGCTTTGCCGAAAGGNACCCTACCATCGTCTATAACATCCTTCTCTTTGGCCTGACTAGT GCCCTGGGCCAGAGCTTCATCTTCATGACAGTTGTGTATTTCGGTCCCCTGACCTGCTCCA TCATCACCACAACTCGAAAGTTCTTCACCATTTTGGCCTCTGTGATCCTCTTCGCCAACCCC

ATCAGCCCCATGCAGTGGGTGGGCACCGTGCTGGTGTTCTTGGGTCTCGGTCTTGATGCCA AGTTTGGGAAGGGAGCCCAAGAAGACATCCCACTANGAAGAGAGAAGACTACCTCNACT CCAAGAATATTTAAANTTATTTTCTCCAACAGTNGACATCTCTTGGGAAAACGGACACAAT TAGAGATAAAAGGGACTATTGTCANTCTGGGAAAAAANANNNNNNACNNNNNNNTNCCN NNGGGGGGGGGCCCNNGGCCCNAATNTTCCCCCCTTTTANGGGGGGNGNNNTNTAAAAA

NNNNGGNNNNNNNNNGGGNNNNNNGNTTN^ TNNNNNCNNGNNNNNNTGGGGNNNNC GCCTATAGNGAGNNGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCNGGNCT GNAGGTTAACGCTGCAGCCTCCGNCGTACCCGCGCCTGANCCNNTGCCAANCGCTTTTGA ACAAGAAGANGGNTGNGCCTNCCANGNATGNTGATCTTGGCAAAACTGNCANGGATGNN TTCAC(^AGGGCTATGGATTTGGNTTAATAAAACTTGATCTGAAAACAAAATCTGAGAAT GGACTGGAATTTACGAGCTCAGGTTCAGCCAACACCGAGACCACCAAAGTGACGGGCAGC

CTGGAAACCAAGTACAGATGGACTGAATATGGTCTGACGTTTACACGAGAAATGGAACAC TGNCAACACGCTGGGCACGGAGATTACTGTGGAANATNAGCTTGCACGTGGCCTGAANCT GACCTTCGATTCATCCTTCTCACCAAACACTGGGAAAAAAAATGCTNNAATCAAGACAGG GTACAAGCGGGAACATATCAACCTGGGCTGNGATGNGGATTTTGACATAANTGGTTCTTC CATTCCGGGGCGCTCTGGNGCTGGGNTATGAANGTTTGCTGGNTGGCTACCANATGAATT

TTTGAACTGCTAAAGTCTCCAAGTGACTCATAAGCAACTTTTNCAGTTTGGCTNACNANAA CCGNNGAAGTNCCAGCTTCNCACTTAANTGTNAAANTGATGGGAACCNCNAGTNTTGGTG GCCTCCCTNTTTTCCAGAAAGGNGAA(^AANAAAGTTTGGANNACCCNCNGTTAATTCTN GCCNTGGACCCNGAANGANAAACAANCAACCACTCCTNTTCGGAANTTANCCTNCCCAAG TCNCCANTTTITSINAACCNNNNN∞

NCCCTGTTTNGGATTAGGGATATACTCCISINAACCCTTN^ CNCTTNGTCTGCTTTGNTTGGNC

GCCTATAGNGAGNNGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCNGGNCT

GNAGGTTAACGCTGCAGCCTCCGNCGTACCCGCGCCTGANCCNNTGCCAANCGCTTTTGA ACAAGAAGANGGNTGNGCCTNCCANGNATGNTGATCTTGGCAAAACTGNCANGGATGNN TTCACaSfAGGGCTATGGATTTGGNTTAATAAAACTTGATCTGAAAACAAAATCTGAGAAT GGACTGGAATTTACGAGCTCAGGTTCAGCCAACACCGAGACCACCAAAGTGACGGGCAGC CTGGAAACCAAGTACAGATGGACTGAATATGGTCTGACGTTTACACGAGAAATGGAACAC

TGNCAACACGCTGGGCACGGAGATTACTGTGGAANATNAGCTTGCACGTGGCCTGAANCT GACCTTCGATTCATCCTTCTCACCAAACACTGGGAAAAAAAATGCTNNAATCAAGACAGG GTACAAGCGGGAACATATCAACCTGGGCTGNGATGNGGATTTTGACATAANTGGTTCTTC CATTCCGGGGCGCTCTGGNGCTGGGNTATGAANGTTTGCTGGNTGGCTACCANATGAATT TTTGAACTGCTAAAGTCTCCAAGTGACTCATAAGCAACTTTTNCAGTTTGGCTNACNANAA

CCGNNGAAGTNCCAGCTTCNCACTTAANTGTNAAANTGATGGGAACCNCNAGTNTTGGTG GCCTCCCTNTTTTCCAGAAAGGNGAACNAANAAAGTTTGGANNACCCNCNGTTAATTCTN GCCNTGGACCCNGAANGANAAACAANCAACCACTCCTNTTCGGAANTTANCCTNCCCAAG T(^CCANTTTTNNAACCNNNNNCGGCCNGGCTTTTNNTCTNTANGTGGAACC NCCCTGTTTNGGATTAGGGATATACTCOSπ^AACCCTTNAANTCCNNGGTNTTAAAACNNN

(^CTTNGTCTGCTTTGNTTGGNC

TTNAAAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNCNAGGTCGAGCTNCACTGCGGCAGCAGCAGAGCGGAGTGTACATTCTGATT

TGCTACGTTTATATATATCTTGAAGCTAAATGTATATATGAGTAGTTTGCCNTGAGATAAC

ACAGTGTAAACAGTAGACACCCAGAAATTGTGACTTCTGTGTTCTCTCCATTTGAGTATTT

TGTAATTTTTTTGAAATATTTGTGGACATAAATAAAAACAAGCTACACTAATTCATACTNA

AAAAAAAAAAAAAAAGGCATNCAGTATNNANGAGAANACCNACANNTAACCCCTGAGAT CNAGCCCGCCACCCTGAANCGNNNCTTCCTGNGGGGGGGGGGCCCCNNCCCAAAGGTNT

GNAGGGAGAGCNANTNTNO^NNNNNNNNTNNNNNNNAANCCNNNCNGANAN^

GAaSTAANNNCCNNNNNNTTTTGNNGCCNNOSINNNNTNNCC^

NNNCNNNNTTCCANNNNNNANNISINN^

NNANNNNNNNNGGNTTTTTTTNNNNNCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCNNN NNNTNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNTS^^

NNTTNNNNNNINNNNNNNNN^

NNNNINNNNNNNNNNNNNNNNNNNNMNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

ANCACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAGCTTATTGAATGAAAACTCCAGAGACTGAAAAACCAAACATGAGGGTAGCAGG TGCTGCAAAGTTGGTGGTCGCTGTGGCAGTATTTTTACTGACATTCTATGTTATTTCTCAAG TATTCGAAATAAAAATGGATGCAAGTTTAGGAAATCTATTTGCAAGGTCAGCATTGGATG CGGTTGTNCGTTCTACAAAACCTCCCAGATATAAATGTGGAATCTCAAAAGCTTGCCCTGA GAAGCATTTTGNTTTTAAAATGGCAAGTGGAGCAGCCAATGTGGTGGGACCCAAAATCTG CCTANAGGACAATGTTTTAATGAGTGGTGTTAANAATAATGTTGGAAGAGGAATCAATGT

TGCCTTGGTAAATGGCAAAACGGGAGAACTAATAGACNCCANATTTTTTGACATGTGGGG AGGAAATGTGGCCCCATTTATTGAGTTCTGAAGGCCATACAANATGGAACAATAGTCTTA ATGGGAACATATGATGATGGANCANCCAAACTCAATGATGAGGCCCGGCGCTGATTGCTG AATTGGGGAGTNCATCTATTACTCATCTTGGTTTCAAANACAACTGGGTCTTNTGGGGNGG AAAAGG<^TTAANACAAAAGCCCTTTTGANCCGCCCNTAAGGAACCNTNGGGGCCCCANT TANTTTGAAGGATGGNCCTGAANTTGNGGAAATGGAAAGGATGCCTTTCCCCAAAACCAA AACTGGCCGGGGNAAAAACCCGANGGGAG(^CCCTTTTCCTTGTTANNGGGNAAAGCCCC TNCCCAAAAAACCTCCNTTTTAAANNTTTTAANAACNTGCCCCCCCTTTCGGGGGGGGGCC TTTTCCCTΓTTTNNTTTTTGNANTAAA

TTGAANACAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGANNTAAACTAGAAATCCCTCTAACCTGTGAATGAAGA GGGGTGGACCCTGAGCAGTGCCTCAATAAAACAAGTAGCCTTACTTGTCAAAATGTAGCT GCATTGAAGTGGCACACTGCTCTTCTGGTCTCCAGAATTTTTCTGTTCTAAACTTGATTCTC

TTAGCCTGTCCCCCACCCGCTTGCTTCCCTACCCTCTTCCGCCTCTCACAGGGGTGATTTCT ACCTCTTGGGCCCAGACAAGATCTAAAAGAGTTCCCAAGTGTTCTCATGAGGCGATGTGT CTGCCCTTGGAGTGTGAGATGCTTCGGTGAGCTGTTCGGACCATCANGCGTTCTGGGCCCG CGTTATGCAAAGAGCTCCGGGAGCCTTTCCTTTGCTTGACAAATGAGCGTTGCGCTCCTTG

CATTTTTGGAAAGCAAAAGCAACTTTTAAAATAG

CTTCCCTTCGAAACTGTTCTGTGAGTCTAANCTGCTGCTCTTTCTTTTTCTCCCTAAAATCT GAGTATTTCTCCATTGTCCCCTACGCCGGAAATACTACAGATGTGGTTTNAATCGAACTGG ACAGGTTCACCTTATACTGGGNAAGAAAATTACCTTCCTTAATTGGCCCAAGTAAAAATTA ACTGTCAAGCAAATATGGTTCATTTGGATTATTATTACTGNAGGTTTTATATTCAANGAAT

TTGGCAAACTTTTTNTTTAANCCTGGGACTTCATTGTNTAAAATTANTTAAAAGGTTTT^ AAANGNGAACCGGANTNAATCAAATAATTTTGAAACAAAACAATGGGGCNTGGANTTTTT TTAAAAAAAA

TTGANAACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNANGAACTANGANGNNCNGGNTGCTNNNTTGTCCNGNNCAAGNGNNANGCT GNTGNGGNNNCTACNAANCTCTGCGGCTNATTGNCTNCTGCAGATGGAGCTGTGCATGGG AGCATCANNCACAGGAGACCTNTGGTNANNNCNCTGTNCTTNNGCCACACCTGNNGNGA GTGNACNGCNTNNTGTTGNCCCTTNCGACCATGAOSINNACCTNAAANNCNGTGNNGNNG

GNTNTNTGANANTATATCCTNTNTNTNTGACTGANACCCAGCAATNNTTNNGGGGGGTCC CNAANCNNATGGGGAAAGGTNGGGGNGGGGGTNTCCCTTCATTAGGAAATTGNAGTANG ATGTCNTTTTATAGAATTGTTTTATTGTATAGTGCTATTTGAATGNTGGAAACGACANAAT NAAACTGCNCCTTACTCTCNNAAAATAAAAAAAANANANTNTTTNNNCGGGGTTTC NNNNTTTO NNTNTNNN

TTNTTTNTTTNTNTNATNTCTNNNNNNTTNTTT^^ ATNTNNTNC(^TTNTCNTNNTTNGNNNNNNCTTTCNTT^ TNOSfTNATTNNNNNCTTCTNNTCNNNTTTW NNCTCTNNA JNNTTANNTNTNNTTTTNTNNTNTrπ

NANTTTNNNTNNNNNNNATNTNNTNNTNTTTNNNT^ NTNTTNTNATTNTTTTCN

NCGNCANNGNTCGCTACCGTNTANNlWTISπ^^

CTCTCT^ATCNNCCA^TCTCCCTC^

NGCAGTNCCNTGCCCNTTTTNCACAAAAACTGGAGCTCCACGCGNGGGCGGCCGCTCTAT ATCTAGTGGATTCCNCGGNCTGNNGGCAATTATTATTTCNTNCTTATTTATACACCTTCGA ATACACTCAATNTANNTATNATNGCCCACTTCTCATCCCTATNNTCGNGTTCCTNTNCTTC NTCTTGNTCNNANACACANCCCATTCTCATTCNATCNACNTTGNTTNTACTAGNTANTTCG

NTNNNTATT(^TCATTATTTTNTATANTNTNNATANACTANATATNATT^ NTTGTCTTTTCTTCATCTTNCCHTT^ TCAACANANTTNTNANTTATTNNNCCC^ CTACTCTTNANNTTCANTTNATT(^TCANTATNTANTNACNATTAATATNATGTN^

NTNCACNTATTNNATACCCAANTATCTTTTCATATCTCANA(^NNCNNTTTNATAATCANAT CTATNTCTNTNNAATCTTTNACAAGCTNN^

GNTTANANTNNANTTNNATTNANNTNCACCTTNCTTCAANTATNATNTCNATGTACNATA NNN( N>JNKCANNAAACTCNTTNNTNCTNTTCCNNNCCTATTNCTAATCN NCANTNANTSRCTNNANTNTTANTNNTTNCTNNNTTANCTCTCATCCANCATTNTCTNCT^^

ATTTNNCNACCNTCNTCNCCNTNTNTTCATANGATANANTATNTTCATNNTCAAACAΠ NCCTNNTAANTTCTTATAACTNNNNTTATNTNAACNNNNCCATGTTATCTNATCNAC AOWTTCTTNTATATATATCT(^CTTTTANCNTNGCATNGNNAAGTNGCNTTTTATC^ NNTATNNNCTTATCNTNNTCATTNNTCNTANNTTANATCTGNCTTCNTANTATACTTCTCA NATANGCATACATCANCTCNACACANTTCNNANCACTGTTATNNANCATANCTACNNTTA

TNCTNTATCTCTTNTNNNNCNTTAACANNTACTCANTATTAACTNGTCATATCTATCNTNT NATTTNTATNNNNTCATACCNTATNNTCTTANATCTATTNATTCTTANTGTCATTATT^ NNTTNTANAGNATAAATTTCNTACNTANCACTATTACATTCTCTAGCGCGATNTACATTNT CTTNTNCGCTNANNCCNCAGTCTTNTACTTANATNATNNTTNTATNCTACTATCCNNACTC TNTNNAOSRTANAATCTANTTNCATTNANNNTTNTCCCTCTNNGNCAATANACNNANANGT

CNCATNCNANGNCTGNACTATAGACACACTATTCCGATNNNTTNTCATATCTCNTNTCACT ANNTANCCC

TTGAGANCNTNNNNTGGNGNNGNANTNCANGGGGGAGTACGCTCTAGAACTAGTGGATC

CCCCGGGCTGCAGGCAATCCNGCANGAGGAGNNGNGCANCTTTCTTCGGTCGTCCCGANT CCGGGGGGCATGCTNACANNNCTCGGCTTCAACCNNTANTCGNGTTGCNNNNCCANCNCT

AGNGNGGNNGANNTNCGGGGNNNNGNNNTCTTNNNNNGGTNANCNTGNGOSπSfCNTNAT^ AANTCANNGAANNNANANCGANGNGCGNNNNGTNATNCNNAGTCCATANCNNNTGCNTT AGCCAGNNCCNNGNTNCTGGAGNANGCTNGNATNGCNGNNTNNNATAGNCCNNTTNNNG

NANAATAGACNNATCNACAGGGNNAGCNGTNGGTGANGNTNGGAGAGNNNTANCATGCC NNNNGAGNTACNTGTTNACOSπsiGATACGGGACCNCGATNGCHNNTNNCCNTAAGCNCNG NANNCNGrøGTαsπS[N<_OTCT GGANCAAGAGNCGNTCGANANTCNTNCANGGATCNNCNTNGCNNGAGNNNGNGCNNATC CANNNCTGNNNTTGNNNNCTGNNGNNCANANNAOSINNTTNCGNANGTNN^

TGTNNNACNATTNNNCMSTTCGAGAANNNCGTNNGANCNATNTCGNNTN^ CGGACNNTC(^GAANGNNNCGGNNNCGGGATTNANANGANNNTCTTCNTNCNNNGAAGN GNNANCGNNTNGTGGGAGNTTGNNNOSINTAGANCATNNNNNAAGNNANNNAAAAGGTT GCNGANACGTGCNAGNNTNNGGCGTCATACGCNNTCGTAGGNCNNTNCTGGNTAGGAGN NNNNNTI^NNTAANNTGATCANTNNCGAT<^

GANTCGNrøvINGGCGTNNNGNGGATGCNCNANGGGNANNCTGNCTGNATGCTANNNTNNN TGTCNNNANT(_^G( NNAGαsπS[CCTNTCNCAGANCATGTNACNCTANCANTNATACATTGN NATNTNAGACNNNAGCTATGGCGTNAGCNANCTANGCATCATNAGTCNTGACANNATNTN AGNNACNGNTGCNANNGCNGGNACTAGTCGNGTGCGTCCCCGNGCGCGNANANANTGTG GTNNTTNTTCCTCCTANNTCNGTATCGNCG

ANNATCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGANTTCGANCNCTTNTNTTTTGAGGCCTCTGACAAAGCCGCAATGTTTNNGACTAGAA ATAATTACCCAGGGATGATCATGACGTACTAAATACCANGACAGAGNCTANGAACTCATT

ATGAAACCATTNACTCGCAATGGNNNNTGCCNATCTGNNACACANGTCCTGTCNTTTCATT CATCTCANATTATTTΓGAATTCTTTCCAAATGGCTGTNGAGNTTANATGGNGGTAGGGCTG TGAGCCATAAATCTGAAGCGTTGANAGCCTTGGGCCTGGAGAGCCATGAANAGGGAAAG AAAAGANGGCNNGTCTCGAACTNAGCCAAGGACCNGATGGATTGCTCGACCCAGACACA GAAGTGAAGCCTGTGTNCACGTGTCGCCCACAGACTGGAGTTTTTGGTGCTGAATACAAC

ANCGTGTTGCTGAAAAACCANGGGTTTNGGTGAATANAATGTTTTGATTTGATTGCTATGT ATGTNCTACCAGTGTGTGGACCTTTGAAANATNATNNAGNTACCCCCCGATTNNTNANAC NAAANAANNNAAACTCCNTCTCTGGGGGGNGCCCCCNGNNNCCCTAATTCCGCCCTTTAT ANNGNNTNCCCCΑSΠNACNNTNCCCTATTTCTTGCTTNNTCTCCTNNGN^ TimX GATTCATTACATTTATCTCNGN^

NCGNTNNTNCCCTNNNNGCT JNNTTTTCCNNAANCCTNNNNTCTGCT^

GNNTCANTGNNTATCCNTTGCGCNTNCNTGTNNAATNTCTNTANCTTTANCTNGNCTTGCC

ATOSlNGTCTNNTTCNαsπSσSfTATCAGTTTNTTTTCGNNTATNC^

NTNTGNANTATCTGTCTNGNNCNNTTTNCGTNANCATCTGCTCTNTTTGNGCANC

TNAGCCTATAGNGAGTNGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGGNTCCCCNG GCTNGNNGGTTGANAAANNAGACANCATNTGNCCNCGCNCNNGNGGNNGGGGGGANNN GGNGNANGNNNGGCNCTTNNGNNGCGCAANGNNAGNNNAGNANNNNNGANGNAAAANC

NNACNTTTTGNNCNNNGGANCNGATACANTTCTTAGGTGNACCCCTNTGTGGNCNGACCG GTGTTTCTCNACAGAGCTNNTGCCAGCTTANTANGCTGAACNCTGTCACTGCATGATNGGT GAANGTCNACGCTTNCGTCTNGAGANTGGTGACTCCGAGCTANNAATTGCTGTCCNTCCG GGGAGCTCTNGGGAGTTCTNGNGCTNTNNNGAAANGGGCCCTATGATAGANGATNTGCAT ACTNCTCTCTGANCNCACTNNTGNCCCNTGCCACANANAGNTTTTTNTGAAACGTGAGTGT

ATCANCCNCTNACCNNCTGTT(^TCNTCACAAATGCNNAGTTCCTNCAGNATTTTGGGCTA CTTTGATGCTCTTCGCCACNCNANNAGGNCCCNTGCAGGNGGAGTGGNCACCCACNCNGG ACNCAANTTTTNTGCTANGGGTTTCATTGANCAAACTTTGGAANGNGNNTGGCCNTGCAN TTANTTCCNNACTGGGNAAGANAAGGANAACTANCNTCCCCTTTTCNTGAAGANTGGNNN TTNNATAT INCTNCCGCCATTTGAACNTN(^ATTTTNNGGNNAAAAGGGACN

CAAANAATNNTTNNTGTAANGTGGNNGNNCNCGGNNNNNTAACANANNAAAAATCTNGN

CTCTTTAAAAC<^CNANATTC rAAAGNCCNNGN^

TTNCCCCCCCCCANTNNAGTCCNAGATNNCTTTTTTTCNTCTCCCNANANTCGTGNCMSrC

TNAGCCTATAGNGAGTNGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGGNTCCCCNG GCTNGNNGGTTGANAAANNAGACANCATNTGNCCNCGCNCNNGNGGNNGGGGGGANNN GGNGNANGNNNGG(^CTTNNGNNGCGCAANGNNAGNNNAGNANNNNNGANGNAAAANC NNACNTTTTGNNOSINNGGANCNGATACANTTCTTAGGTGNACCCCTNTGTGGNCNGACCG

GTGTTTCTCNACAGAGCTNNTGCCAGCTTANTANGCTGAACNCTGTCACTGCATGATNGGT GAANGTCNACGCTTNCGTCTNGAGANTGGTGACTCCGAGCTANNAATTGCTGTCCNTCCG GGGAGCTCTNGGGAGTTCl^GNGCTNTNNNGAAANGGGCCCTATGATAGANGATNTGCAT ATCANCCNCTNACCNNCTGTT(^T(^TCACAAATGQWAGTTCCTNCAGNATTTTGGGCTA

CTTTGATGCTCTTCGCCACNCNANNAGGNCCCNTGCAGGNGGAGTGGNCACCCACNCNGG A(^CAANTTITNTGCTANGGGTTTCATTGANCAAACTTTGGAANGNGNNTGGCCNTGCAN TTANTTCCNISfACTGGGNAAGANAAGGANAACTANαSfTCCCCTTTTCNTGAAGANTGGNNN TTNNATATNNCTNCCGCCATTTGAACNTN(_NATTTTNNGGNNA CAAANAATNNTTNNTGTAANGTGGNNGNNCNCGGNNNNNTAACANANNAAAAATCTNGN

NCNGNNCTCNCTNNNGGGGNGGGNOSπStNNCCGNCCCATNNTTNTTGTTTT CTCTTTAAAACOSfCNANATTαWAAAGNCCNNGNNCCNTTNCCCNTGNCNCGGCNNNT^ TTNCCCCCCCCCANTNNAGTCCNAGATNNCTTTTTTTCNTCTCCCNANANTCGTGNCNNCN

TTGAAAACATCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGNCANGATGCNTTTCGNTACCGNCNNACTGGANGGN WAC>ΠSINGNN CAGNNNCCTTCNTATANTGNTTNNTANTAAAGGNNTANATGAGTNCTTTNNCNTNATATA CCTCAGNGTACA(^CTNNACTCCCAGACATTNTNACTTCTGCGTTTTNTCNNTTGAANTAT NTGCTATΓNGCΓΓTCGAANTTATGCTACGACNTANNAACAGACNANCTGCACT JNTTTATN

TNACAAACCNTSINATCCGNGNNNNTATCNTGCN^

TATATTCTGNCCCTCACACTGCANNGNTNNANNTCTTGANACTGGNCGGCNCNTATNTGN ANGCTCTGGAANGNNCATΑSΠSΠSFCNNATCAAATNANATCCCNTNNNTANTCCNAAGNNTTT NTCCTTNNAANAC TAGCACNC<^TTTNCCGNTC NOSINNAGNTNTTANAACCCTNTNΑSLNAAATTTNNTGGNTNTNGNTTNNA^

CCTTTAATTACRØNFGNTNTCTTANATTNNACCGGNGNTTTTTNTAAACCATT^ NTGGTTAAAATTCCTTTNTCCGNAAAA⁽^CCCTTTTNTAAANTNAANTGGNNNANTT^ NAANNAAAACACAANNTTTNTNTTTTTTNGGGG AANTTTTTTTNCTTTNAAACNAAANA^ TAAATTTNCCCNNTNTT CNCTTTTNTATTCTNCTT^ NNTTAT(^TNNαsrC(-NATTITTNNNTCTCCCTNTT^

ATCTTTNANNCNATNNNNNCTCT

TTGAGCCTATNNGGAGCNCGCATNNCNGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAGNTAAGGCTGAGAAGNCNGATACTAANNNGAAAAANCCTGTGCCANGAN GGCTGANNCTGGCNAGAAGGCTAAANAGGTGGAAANGGTGACNAANGTTANGAAGGGN AAGCCCCACTGCAGCCGAAATCCTGTCCTGGTCAGAGGAATTGNCAGATATTCCCGATCA

GCCATGTACTCCAGAAAGGCCTTGTACAAGAGAAAGTNTTCAGCAGCTAAANCCAAGGTC GAAAAGAAAAAGAAGGTTCGTGTTCTTGCTACTGTCACAAAACCAGTTGGTGGAGACAAG AATGGTGNACCCGAGTGGTCAACTTCGCAAANTGCCTAGGTATTACCCTACTGGAAGATG TGCCTCGAAACCTGTTGAGTCATGCAAAAAACCCTTCAGTAAGCATGTGAGGAAGCTGCG TGCCAGCATTCACTCCTGGGACCATCCTGATATTCCTACTTGGGCGCCACAAANGCAAGA

NGGTCGNTTTCCTTNAANCAGCTGGGCAGNGGCTTGGTTACTTGGGACTGGGNCCTTTATC CCTCAATCGAGTTCTTTGNGGANAACACACCANAAAATTGNTATTTGCCNCCTNCACCCA AAAATCGNTTTTCAGGNGGGGGNGNAAAATNCCCANAANATTTTTACTTGANCCTTTACT TTAAANAAANAAAAAAACCTGGGTTNAAACCCCANACCCCCNGGGNGGGCGGANATNNT TCGACCCCCGGGGNGNGNGGGNAANTTTCCCGGGATTTCCCCNGGCCNCGCNCCANGGGT

NCANTCCAAAAAAAGCTTGGGGGGCCTNCNAAAAATTNTNGNGGAANNAAAANAAAAAC GTNTTCCTTTAANGTTTCCANGGGGNTTCCCTTCCCCTNCCGGGGTTTNGCTTTCCCCCAAA AGGGGAANTTTTTTCTCNCCAAAAGGAGGGNGTNN

TTNANNACAANCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGCCAGATTTCCTTTTCTGTTTTTGGATTGCTGGCAGCTTAAGGGCCAAAGAG GGTGGTCATAGTGTTAGTTGCTCAGTGGTGATGGACAGGGAAGCCTGGTGTACTGCAGTC CATGGGGTCACAAAGAATCAGACACAACTGAACTCAATTGAACTGTGTCTCTTTACAACC TGATAGACTGTAGCCCACCATGCTCCTCTGGCCCTGAAATTCTCCAGGTAAGAATACTGGA

GTGGGTTGCCATTTCCTTCTCCAGAGGATCTTCCTGACCCAGGGATCAAACCCAGGTCTCC CTCATTGCAGGCAGATTCTTTACCATCTGAGCCACAAGGGAAGCCCAAAATGGTTGGCAG GCAGGCTGAAAACACCACAGACATTTCTTGAGTTTATGTGCCTTTTAGTGTAAAGGGTCAG AGGAAΛGAGAGTCATTTTGAGAGAGCAAAATGACTTTTTCTTTTTATCTTCCTACTCTCπ^ CTGAAGTGCCATTTGAGACTGCAGTAAGGTAAGGGAAAGAATGCTTTCCTTCATGAAAAG

AGGCAGGGGATCAAATTGATGTGTAACTTGGCCTAATGAAGGACTCCCACGCCGATTGTG GNTGACTTGCCTGCCTGCACANGTGGTGGAGGNAACGATGTGGTTTAACCGNGGTGAACT CTGATAATAANCGGCTGGANCCGAAATCCCGCCGGGAAAGCCTGGGTCTNCCTCTAACCT TAATTTGGGGGCCTCCCANAACTGGNCCAGGNAATTGGGCTTCNCGCCGGGTTCAAAAAG NCACCGNGANCCAAAAACTTTTGAANGGGTTTGAAAAACCTTTTTGGNCCAAACCTTGNA

AGGGGANGGCCCCTTCCCCAAAANCCTTGTTGNAACCCNCCAAGGGAAANCCCANGGN

TTGANCANAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGGAAGAACTCTGATGCAGAGGTTGCACCTTTTCCCAGATGAAGATATACCAGN

AGATATTCTTAAGAATTTAACAGAAGAGCTTCCTCAACCACGAAAAGTGCCCAGACGTCT AGATGAGTACACACAAGAAGAAATAGAGGCTTTCCCAAGAGTTTGGTCTCCACCTGAGGA TTATCGGCTGTAGGAGGAAGAAAATTTCAGAAAATAACGGTGTGGTGCTTGAAACTCCTT CCTCAGGGCAGGATGAAGCAATAGCTGCCTTCTGGAAGGAAGCCTGCTCTGGGGGCTGAA AGTTTGTGGGGAAAGGTCGGGAAGGGGTATCCCTTCATTAGGAAATTGCAGTANGATGTC

ATTTTATAGAATTGNTTΓATTGTATAGTGCTATTTGAATGTTGGAAATGATAAGAATAAAA CTGCGCCTTACTTCAAAAAAAAAAAAAAAAAAAAACCTTGGGGGGGGGCCCGGCCCCNA ATTTCCTTNTANGGGAGNTNNNTANNNANNNNN^ GANNNNCNGCCTGGGNTNAANTNNNNO FTNNNNTTGNCCTNGGGAN^ NTTGGGGTTGNCTNGCCTTNT-KNCCTNNNNNGNGGNNGGAACCATGGNO^INCCNNGNN

NNNCNNTNGNNNNNNNNGNNN^ ANNMSTAATTNGNNNGNNNNNN JNNNNNTSΠSRCNNNN^ • NNNNNNΑSLNNNNOSTNNNNNTTTNNN NNNNNNNNGNCCCCCCCCC AAAANCTGGAAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAAATTCGATATCAAGCTTATCGATACCGTCGACCTCGAGGGGGGGCCCGGTACCCA ATTCGCCCTATAGTGAGTCGTATTACANNNNNNNN^

NNNNNNNNNNNNNTSINNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^

NTNNNNNNNNTS1M [NNNNTNNNNNNNN^

NNNTNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNτ>INNNNNNNTNCNNNNNNNNNNN^

NNANNNNNNNNTNNNNNNNNNNNNNNNNNNNT^

NNNNNNNTSπSiNNNNNNNNTNNNNTNNNN^

NNNNNNNTsπSINNNNNNCT^^

NNNNNNNNNNNNNTNNNNNNNTNNNNNTN^ NNNNNNNNNNNNNNNNNNNNNTTNN^

NNrWACNNCNNNNNNNTTTATNNNTCNTNNNNNNNTNNNN^

NTNNNNNNNNNNNNNNNNNNNNNNANNNN ^^

NOStNNNNNNNNOSlNNN>WrNNTNNNN^

NNNNTWTNNNNATNNTN^ NNNNNTCNTNANNNCNNNTNNNNNNNNNNCCNCNNN^

NNCAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAGAGGTGCAACTTTCTTCGGTCGTCCCGAATCCGGGTTCATC CGACACCAGCCGCCTCCACCATGCCGCCTAAGTTCGACCCCAACGAGATAAAATGTACCT

GAGGTGCACCGGTGGGGAAGTCGGTGCCACGTCTGCCCTGGCCCCCAAGATCGGCCCTCT GGGTCTGTCTCCAAAAAAGGTCGGTGATGACATCGCCAAGGCAACTGGTGATTGGAAGGG TCTGAGGATTACAGTGAAACTGACCATTCAGAACAGACAAGCCCAGATTGAGGTGGTACC TTCTGCTTCTGCCTGATCATCAAAGCCCTCAAGGAACCACCAAGGGACAGAAAGAAGCAG AAAAACATTAAGCACAGTGGAAACATTACTTTTGATGAGATCGTCAACATTGCCGGCAGA

TGCGGCATCGGTCTCTAGCTAGAGAACTTTCTGGGAACCATTAAAAGAGATCCTGGGGAC CGCCAGTCTGTGGGCTGCATGTTGATGGCCGCCACCTCATGACATCATTGATGATATCAAC AGTGGCGCAATGGAATGCCCGCTAGTTAAGACTGCAAAGGAAAATAAANGGACCATTTG ACACCAAAAAAAAAAAAAAAACTNGNGGGGGGGCCGGGNCCCAATTTCNCCCTTTAGGG GGGNNNNNNNNTNNANNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNTSnSlNNNNNNNNNNNNNNW NNNNNNNNMvTNNNNNMslNNNNNNNN^

ACAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGCTGCCTGTTACAATAATCAGCAGGTGTTCAAGGGGGTGGT GAAGATTCNAAAAGGGCAAGCGGTCACCCTGATGATGGATGCCACCAACATGCCAGCTGT AAAAGCCATAATACACCAGTACATGGAAGAGATTTATCACAGAATTCCCAACTCTGACCC

CTGTTCCACTAAAACACAGCAGATCATCTCCACCATCAGGACACAGAATCTCCCCAACTGT CAGCTGGTCTCGCGGAGCCACTACTCGCCCATCTACCTGTCGTTCGTCATGCTCCTGGCGG CCCTGAGCTGGCAGTACCTGAGCACCCTGTCCCAGGTCACAGAGGACTATGTTCAGACCG GGGAGCACTGACTGGCTCGGTCTGGAGACTGAACGCCCCTCCTCCCAAGCCCCTATCTGG GAAACAGACTGACCTTCTCTTCAGGGATGGATGTGGGCTCCTTCTCTTTTTTCCCCTACTGT

NTTAATCCCTCAAAGAGTACTGTGGGCCTGGACCTTTANAAACTGTGACCTGTGGTGGAG AAAAAGATAGGATTAAAGGGAAAGGACAGCTCAGCCACCTGTACTCACCTGTGCGGGGT GACTGACGCCCGAACGTTCACGGNTGCCATCAAGGAAAGGGCTGCATCCGGGGCTTGNAG AGGAAGATCATAGTGTGAATACAGGGCTANAGTTACAANTAAATGTATTTAATGCCGAAC CAAAAAAAAAAAAAAAAAACCTNGGGGGGGGGGCCCGGGNCCAATT CCCCTTTATNG

GGGGGNGNTTTNAAANNNNNNNNNNNNNNN^ NNNT[NNNNNNNNNNNNNNN TTGAGNCCTTNTAGTGNNGTCGTANTTACAGTGGNGGCCGCTCTAGAACTAGTGGATCCC CCGGGCTGNAGGAAATTCGGCACGAGGAATNNNTNTATCTGTGATGGTGGCNNGAAGAC CGNGNNTGTCTTGCCANAATGNNTTANATANANCAAANNTGTNNCTGCNCNTACANGNNA ATA(^TANCTTNTGGGCOSfAGGGGGAGTGNATNCGNGNNGAANTCNα^CTTGCNCANCTT ANTGATCANGTGCNANNCACNNNNTANNAGNCCATGATCNTCCTGNCCGGGACTCNGGTG

GATNN^ANGNO INNNTGAGGCCANCGANNNGANAGC^GNCTNAAGCACTTTATNCAANC TCTCTGGGGCTGTGGNTATGCNTNTCATNATTGGTATTACGNCCCGNTCTTGCNCCTTNNG NTTNCCTNGTANANNCACCTACCAGGNNNGGAAGACNAGTCNGNATTAGNTNGNTTCNG GTNGGNAATOWTGATATTTTNNNTNGGNNNA^

CTTG(^TTGGNCAGCCCTTCNCNTCTANTNTNTNATTNCTTTTTNNTGGATCCTCAN^

TTOWCNATATNNTGC WCGNCCNCTC^

GNNTNANTNCGTTNACNCCCTCTNNNNATATTNCTNAANGGGGNTNNNGGTTNGNNT^ NTTTATTTATANANGNNTCNGNGNNTTNTANNTANNNCCCNANNNNTCNATAAGAATCCN NNTGATCTNTCAGNNANCTCTCGTTTCCTCTTNGNNNNNCCCCNCAATAGTNNNTNATNCN

ATNTAGNGNOStNGNANCATTGTCNCTTNNNGTNCTCTNAGTCCNTCAACNATGATNGTCT CNNGGNNNATTNTNTATCTNTCCCTNTNANAATTANNNTAGNAGATNO^NNTNTCGNNNC ACNTAATAACTNGATGTNGCTCCTAGGATTTCNCTTTGNGCNCTNCG

TTGAGNCCTTNTAGTGNNGTCGTANTTACAGTGGNGGCCGCTCTAGAACTAGTGGATCCC CCGGGCTGNAGGAAATTCGGCACGAGGAATNNNTNTATCTGTGATGGTGGCNNGAAGAC CGNGNNTGTCTTGCCANAATGNNTTANATANANCAAANNTGTNNCTGCNCNTACANGNNA ATACNTANCTTNTGGGCCNAGGGGGAGTGNATNCGNGNNGAANTCNCNCTTGCNCANCTT ANTGATCANGTGCNANNCACNNNNTANNAGNCCATGATCNTCCTGNCCGGGACTCNGGTG

GATNNNANGNOSlMSfNTGAGGCCANCGANNNGANAGCNGNCTNAAGCACTTTATNCAANC TCTCTGGGGCTGTGGNTATG(^TNTCATNATTGGTATTACGNCCCGNTCTTGCNCCTTNNG NTTNCCTNGTANANNCACCTACCAGGNNNGGAAGACNAGTCNGNATTAGNTNGNTTCNG GTNGGNAATαsπSTTGATATTTTNNNTNGGNNNAAGGGCGTCCTCCCNNCATTTTTGN NANNACTACTNGAGNACNNCTNTAACTNNTTATTTTTTTAATTTTC(^TCT^

CTTGGNTTGGNCAGCCCTTCNOSfTCTANTNTNTNATTNCTTTTTNNTGGATCCTCAN^ TTTN CNATATI> OC]SrNCGNC<^^

GNNTNANTNCGTTNACNCCCTCTNNNNATATTNCTNAANGGGGNTNNNGGTTNGN^ NTTTATTTATANANGNNTCNGNGNNTTNTANNTANNNCCCNANNNNTCNATAAGAATCCN NNTGATCTNTCAGNNANCTCTCGTTTCCTCTTNGNNNNNCCCCNCAATAGTNNNTNATNCN

ATNTAGNGNCNNGNANCATTGT(^CTTNNNGTNCTCTNAGTCCNTCAACNATGATNGTCT CM^GGNNNATTNTNTATCTNTCCCTNTNANAAT^^ ACNTAATAACTNGATGTNGCTCCTAGGATTT(^CTTTGNGCNCTNCG

TTNAAAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGCGGCGCCCAGAGCCGGNTCNGCGCGTNNACTGCCCA GAGTCCGCGGCCGNNGCGCCCCGAGAAGCCAAGCANCCATGGCCTATCACAGNTTCCTGG TGGAGCCCATCAGCTGCCACGCCTGGAACAAGGACCGCACCCAGATCGNTATCTGCCCCA ACAACCACGAGGTGCACATNTATGANAAGAGCGGGAACAAGTGGGTCCAGGTGCACGAA

CTCAAGGAGCACAACGGGCAGGTGACAGGCATTGACTGGGCCCCAGATAGTAACCGTATC GTGACCTGTGGCACAGACCGCAACGCCTACGTNTGGACNCTGAAGGGCCGCACGTGGAAG CCCACGCTTGTCATCCTGCGCATCAACCGCGCCGTTCGNTGTGTGCGCTGGGCCCCCAATG ANAAAAAGTTCGNTGTGGGCAGTGGCTTCCCGTGTNATCTCCATCTGNTATTTCNAGCAGG AAAATGACTGGNGGGNGNGCAAGCACATNAAGAAAGCCCATTCCGTTCCACCGTCCTAAG

CTTGGACTTGGCACCCCAACAGNGTGCTTCCTGGCCGCCGGNTTCTGNNANTTNAAATGCC GGATNTTTTCAGCCTACATTAAGGAGGNGGGNGGAGNGGCCAGCACCCCACCCCGNGGG GGTTCCAAAAAGCCGTTCCGGGGAACTTGATGNTTCAAATNCCAACAATAACCTTGCGGT TGGGGNGCATGGGGNTTTGGTTTTTTNGGCCAAACGGGAANTNNTGTAANCCTTGGGGTN AACCNCCAAAAAGNACCCNGGGGGCCTTGGGTTTGATGCTTGAANAAAAAAAAAGGGCC

GNNNNGNAAANTTTTGGCCTTTTGAAAACCCTTTO^ TAAANGGGGAAGGAGGNT TTNAANCNCNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAATTCGGCACGAGGGTTTTATAAATTTAATATATTTATCAAGCCAAATGTG CAGATGCTAACTGGACGCTCTGGAGAAGTGGGCCCAGGGACGCCCNACCCTGTTCTCTNT TCAGCAGTGGGAAGGCCACATATTTCAGTGGCCACAGCCACAGGAAGCTCAGATTCTCTG GCTAAAGGTAACACTTTGCCCTCCTGTGCTCCTCTTANCTTCCCGCCACCCCCAGGTAGGG

GGCGAGAATGGCACTGGAAAGGCCTGGCCCTAAAGTATAGTTCTTANAGCAAGGGGAGCT TANACCTCAGGCGCCCCCAGGGAGGCCTTGAGACTGGGCAGAAGGGTTCTGGTTGCTAGA GCCTGTGTGCAAAGGGGTGCCAGCAGCCCCCCTGAGCTAGTGCTGGGAGGACTAATGGTG GGGGGGGGGGCCTGNTACTCCCCTNAGTCCCCTCCTCCNTGTTGACATNTGGGGCTTTGAC CCTTTOTTTTTTAATCTACTTTTGCTAAAAAGCNTTTAATAATA^

TGCAAACCTTGTTTCCCTCNCCTTTTGGGCTTNTNGGAATGTCATCACCTCCANTTTGTTGG GTTTGTTTCCACTTGTTAATAAAGCCTTTGAAACCGTNAAAAAAAAAAAAAAAAAAACCT TGNGGGGGGGGCCCCGGANCCCAAATTNCCCCTTAAANGGAGGNNNNAAAAAANNNNNN NNNNNNTSπSfNNNNNNNNNNNNNNNNT^^ NNNNNNNNNNNNNNNNNNANNNNNNNNNNN^

CCNNNCC^GGNNNNN(^CNNCMNNAAANGGNNNNTTNTNNCNNNNNA NN

TTNANAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGGTGAANACCACCGNTNNNNCTAAGCCANAATGGGAAAGGNGAANACCCNNAT CCANATCNNTGTCATTGGGCACGTAGATTCANGGAAGTCTACCACGACTGGCCATCTGAT CTACAAATGTGGCGGGATCGACATAGAGAACAATTGAAAAGTTCGAGAAGGAGGCTGCC GAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAACTTAAAGCTGAACGT GAGCGTGGTATCACCATTGATATCTCCCTGNGNAAATTTGAGACCANCAAGNACTATGTT

ACCATCATTGATGCCCCAGGACACAGAGACTTNATCAAAAACATGATTACANGCACATCC CAGGCTGACTGTGCTGTCCTGATCGTTGCTGCTGGTGTAGGAGAATTTGAAGCCNNNNTCT CCAAGAACGGGCANACCCGTGAGCATGCCCTTTNGGCTTACACCNTGGGTGNGAAACAAC TAATTGTTGGCGGTAACNAAATGGATTNCACTGAGCCACCCTATAGCCAGAAGAGATCCC ATGANATTGTTAANGAAGTCAGCACCTATATTAAAGAAAATTGGGCTCANCCCCGACACA

GTAGCATTTGTGCCAATTTCTGGGTGGGAATTGTGCCAACCATGCTAGAAACCAAGTGCTA ATATGCCATGGGTCAAGGGGATGGAAAGTCACCCGTNANGGACCGGCNATGCCAGTGGG AACCCACCCCTGCTTGAAGCTTNTGGAATGGANTTNTGGCCANCCAACTTGGNCCAAATT GAAAAAΛCCCTTGCGTTTTGCCTTTTNCANGGAAGGGCTAATAAAAAATTGGGGGGGATT GGGACCTGGGCCCCTTGGGGGTCCGGGGGGGGAAAANTGGGTGTTTTTCNAAACCTNGGN

GTNGGGGGG

ANAACCGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTNGATACNAGGNNNNTNGATNCNNATTGNNTGGNAGGAGACACCCNNNCTT

NTTCATGTSINCATCTNNNTNNGAGTNNCTCNGTCCATTCTTGCNTNCCGCATGCCTCTACTT

TGACTGACATTCTGTGTNGNAAANNTGNNCAACCACTGTGGGGANCANCCCTACTGANGG

AANANTGNTATANGNCNATNCCATAACCTTANTGACNNGGNTTATNNATCNCCAANNCTA

CTTGGGTATGGNAGTNGACTAGATGTNTNNTAACTTNTGAGTATTNTTTATTNGANGCTTG GCTNACATATAGACTTAAACTGTCAGCTTGGANNNGTCTATTNCTTAAACTTTGNAANATA

TATATATATTCTTGNTCTTCCATTGAATGCAAATTGATAGACAAAGATGTACNATTGCTCT

GTTGTNTGTTNGGATTATGAACGAAATGGTTGTGACCAATTTGGNGGAAGGGACACACAC

CAANTCCTGGGGATGGNTATGTNTANNNTNCTTGGCATTGGCNTAAATNNTTGANAGTTC

CCNTTCCCATTNACACTCCCATNATGCTTTAAANNAAAAAAAAAAAAAANANNTNNGGNG GGGGGGGCCCCCTGACCCCANATTTTGGACTTTTNTTGGAGNGCTTGTTTTAANAANTTGG

NGNAAANTNTNNTNTNNTTCTTTTTTGGGNGGAANCCCNTNCTTCCCTTT^

NAAATTTTTNTGANCNTNAAAGGGNGACAAAGANNAAAAC^^ N_TTTTTTT(XNC(^_{cc( α}^^

TTTTTNNAGNNNTTNNNNAAATTNTNNTNTTCTCTNCNAA^ TCTCTNCNNGAAAANAANANT

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGGGAGGGCNCGAAATTTGAGGTGATGAACTCCTTCGAACTGCTGTCCCACACCGTGGAA GAGAAGATTATCATTGACAAGGAATATTATTACACCAAGGAGGAGCAGTTTAAACAGGTA TTCAAGGAGCTGGAGTTTCTGGGTTGGTATACCACAGGGGGGCCGCCTGACCCCTCCGAC ATCCACGTCCATAAGCAGGTGTGCGAGATAATTGAGAGCCCTCTGTTTCTTAAGTTGAACC CTATGACCAAGCACACAGATCTTCCTGTCAGCGTCTTTGAGTCCGTCATAGATATAATCAA TGGAGAGGCCACCATGCTGTTTGCTGAGCTGACCTACACTCTGGCCACAGAGGAAGCGGA

ACGCATTGGGGTGGACCACGTAGCCCGAATGACAGCAACAGGCAGTGGAGAGAACTCCA CTGGTAAGGGTGGCTGCAGGGGCTTCCCTGGAAGTGGGGGGNGGNGNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNlSπsπSJNNNNNNNNNNNNNNNNN^ NNNNNNNNΠNΠSΠSΓNNNNNNNNNNNNNNN^

NNNNNNNNNNΓNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNΓNNNNNNNNNNNNNNNNN^ NNTSINNNNNTSINNNNNNNNNN^

NAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGATATCAAGCTTATCGATACCGTCGACCTCGAGGGGGGGCCCGGTACCCAAT TCGCCCTATAGTGAGTCGTATTACACCTGATNNNNNNTCAACNANANAGNTTGTTGCCTA

NNGNNATNACTNNGCNNNTAC π^πsrGGANC^^

CNNNTGCACNCTANAANCACATANNNTTCATNTNACNATCANNACNCAAGANTCNCACTT

CNNN.TTNNNTCTNTNGNTNANNCNGNGNAAATANTCANNTNNTAANANGATNTNNTTTAA

TNTNNANTNCNTGTCCANCCNTTNTTTT^ NCTTNANGTTTNNTNNTTNANACC^

NNNT<^TNTCTTGNAACAATTTNCTANTATNG^

NNTGATGTNNNNCNTTTTATNTTITITTGNNGTANN^

TNGTCNCCNCGNTNCTTTNTNAANNNN(^AANCNTNNTCTNN>WNNTNATTGATC^

TCTNTGGCNANNTNGACTTN(^TANNCNNCCTNNTNCACCTCNNGGNGTCTNTNTTNGAN ATNACNCANGANACTGTTOTNACNCTATATCTTCTTGTNCNCCTNNGANTTCNCNNTATAN

ANOSfCNATT(^ATTTTTNTCTTIMSπsrCTANANATNCTTACCNT^

TNTTTTNATACTTTTATTNA JNTNTTN^

AACTNTCNTATTCCATNTNNANNATCTNCCTNTCNTNCTTTCAATTANTTNTN^

TANTTNCNNNTNCNTTNTCCσsπSTCATTTTNNAGCrrCC^ TNACNANNTNNCACCCCTTNTNACTCTCTNNCACTANTCCCCTCCCCN

NNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGTAACACTCTGTTACTGGAGCCAGCTCAGCTCAGCGGAGCAG ATATAAACCGAGAAGGGCAAACTCATCGAGAGGGCGTCTTCGGGACCATGGCGAATGGA

TATACATATGAAGATTATCAAGACACTGCAAAATGGCTTTTGTCTCATACCGAACAGCGA CCTCAAGTGGCAGTGATCTGTGGTTCTGGGTTAGGAGGTCTGGTTAACAAATTGACTCAAG CCCAGACCTTTGACTACAGTGAAATACCAAACTTTCCAGAAAGTACAGTGCCAGGTCATG CTGGTCGACTGGTGTTTGGGATCTTGAATGGCAGAGCCTGTGTGATGATGCAGGGCAGGT TCCACATGTATGAAGGCTATCCGTTTTGGAAGGTGACATTCCCAGTGAGGGTTTTCCGGCT

TCTGGGTGTGGAGACCCTAGTGGTCACCAACGCAGCTGGAGGGCTCAACCCCAACTTTGA GGTTGGCGATATCATGCTGATCCGTGATCACATCAACCTACCTGGTTTCAGTGGTGAGAAC CCTCTTCAGAGGGCCCAATGAGGAAAGGTTTGGAGTTCGTTTCCCTGCCATGTCTGATGCC TACGACCGGGATATGAGGCAGAAAGCTCACAGTACCTGGGAAACAAAATGGGGGGAGCC AAAAGAGAGTTACCAGGGAAAGGCACCCTTACCGTGGATGTTGGGGGGGGTCCCCAAATT

TTTTGANAACTGNNGGGCANAANTGGTCCCCCTGCTTGCCGGGAAATCTTAAGGGCCANA ATGCTTGGTTGGNCATTGAAACACCAGGTTCCCANAAATTTNNTATTTOS1NCAAGAACACT TGNGGGACCTTTCGAGGNα TTGGCTTTCTTCACTTCCATANCAAAACAANGGNC

GCCTATAGTGAGTCGTATTNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTGC

AGGANTTCGGNACGAGGAACCNCTTTAT(^GTGATGGTGNNNGGANAACCNNGANGGTC

TNCCCANAAGGGNTAGAANTANCNAAACTNGNGGTTGTNCGACCCTTGATTCNAAACNNT

TNGGNNNAGGGGGNANNNNACGANANGNAANNC(^ACTNNNNANTTTNATGNTNAANTN CCAAACNCCNANTCNNAAACCCANAATCTTCTNGCNGGGAANTCGGNGGGCCNAATGAA NGGNGNNCCCCTTNACCGNGAANGGTTAACACACTTATATCCAANCCCCTTCGNGGTGTG NGGAGAGCAAANANNGANATGTGNTGACACNCCCACGTGNTATCGCGCGCNCATATATG TGCACGANCACGANNCCATGTGAGAAANTTTGGTTTTNGAAAAGCGANNGAGACNCNGT NGCTCTTATNAAAGGGGGGCAC^CNCMNNTGTGNTTTTTACACAAAAANTCTCACTCTAC

NNCCTTTITATAATATGGCCCCC^CACCTGGTTTGNNAACCTACTANGGTCAANNGTNTTT NNTANTGGTGCGGCCNACCTTCTTCGNCNTTATACTANCTTNNGACCTNTTGTTGAGACCC CCNAAATNGGTTNATTCCTNGGNGAANAAAGCANNCCTNCTGNTAATTATTCCTNCGAAG GATGGGTNC^TCTTGTTANNCCCANCCAAAAAAAATTGGGGTGGGNTTTCTTGGGACCNC CACNNANGGAAANAAATGANGTTNCNTTNNTGACCTTCTTTTNTTCTTN^

AGCTTNATTAACTTTTTTTNTGGGGNACGNAGNT^^ CNNTTTATGGAGGGAAAAAATTCNTTNNNTAAACCCCTO^ AAAAT]SINTTNTG<- GGCGGTNTTTNCCT^^

GCCTATAGTGAGTCGTATTNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTGC AGGANTTCGGNACGAGGAAC(^CTTTATCNGTGATGGTGNNNGGANAACCNNGANGGTC TNCCCANAAGGGNTAGAANTANCNAAACTNGNGGTTGTNCGACCCTTGATTCNAAACNNT TNGGNNNAGGGGGNANNNNACGANANGNAΛNNCCNACTNNNNANTTTNATGNTNAANTN CCAAACNCCNANTCNNAAACCCANAATCTTCTNGCNGGGAANTCGGNGGGCCNAATGAA

NGGNGNNCCCCTTNACCGNGAANGGTTAACACACTTATATCCAANCCCCTTCGNGGTGTG NGGAGAGCAAANANNGANATGTGNTGACACNCCCACGTGNTATCGCGCGCNCATATATG TGCACGANCACGANNCCATGTGAGAAANTTTGGTTTTNGAAAAGCGANNGAGACNCNGT NGCTCTTATNAAAGGGGGGCACNCNαsπSfNTGTGNTTTTTACACAAAAANTCTCACTCTAC NNCCTTTTTATAATATGGCCCCCNCACCTGGTTTGNNAACCTACTANGGTCAANNGTNTTT

NNTANTGGTGCGGCCNACCTTCTTCGNCNTTATACTANCTTNNGACCTNTTGTTGAGACCC CCNAAATNGGTTNATTCCTNGGNGAANAAAGCANNCCTNCTGNTAATTATTCCTNCGAAG GATGGGTNCNTCTTGTTANNCCCANCCAAAAAAAATTGGGGTGGGNTTTCTTGGGACCNC CACrøANGGAAANAAATGANGTTNC^TTI^ X ^ AGCTTNATTAACTTTTTTTNTGGGGNACGN^

OSINTTTATGGAGGGAAAAAATTCNTTNN^ AAAATNNTTNTGCNGGCGGTNTTTNCCTTTNNNNCGGGCCTTN

TTNANNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGATTTTAATTGACATCTCACAGAGGTCCAGAGACATANAAAGACTTAACCAAA GTTAGGGTTGGAATTAGAGAAGCCAAATACCCTTTTTAATCAAGATGATTCTGAATATTTT TATGCTGATAAGGAANCAGTAAAAGTGATTATTAATTTTTTTTCTCTTAAAGTTTGGATCC TGGATGCAGTTGGAGGACAAGAAAACCCTGCTCTTTCACTGTGATCACNGTNGNNTACAA ATGATTGTAGCTGATAAAATTTCNGATGTTGGGTTNCCTCCACACANACTTTNCCAGACTG

TCCTTNACATTATAAGACGACTTCTTTCCAACTTCCTTACATTTGGGAACTTTAGATTNATA GGGTATTGGGTWCTTAGTCTTAAAAGCCTGGAGAACNATAAAAGAAATTCCTTAAAATTT TAACCTGGTTTCCTAAGTAACAGGANCGGAGTTCCTTGGAAACAAGAAAGGCCNATNCCA NTAGATGAAGNGTTTTTTTACAGGTNTAATAAAAAGTTNCCATGGTTAAAGGGAACCAAA ACCGGACCGATAAGANAANAGTTTTAANATTTGGCCGATAAGAATTTGGAAAAATGAATG

GCCCNTTGAAGAAGANAATGGTTCACCTTGGNAAGGATGACCTTGGNTTTGGTTGGCANC NTGGAAAAAAAAAGCAAANGGANCTTAGGGNTGACCTCAAAANATGAAGGATTCCNAAA TATGACCANCCTTGNTAANTTGGGAAGNAGGANGAAANTTTCCCTTAGGAAANNTTGAAA GGAAAAATTTNCCTTNAAATTTGAAGGAAANAAGGGGGGAACCNTTTNNNGGGGGGGGG NNNNMSINGANNNAAAAAANGNNGGGCCTTCT^

TTNAAAAANCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGAGGAGAAGGGCACCACTGAGGAGGTCTGCCGCATCTACCT GAGGCGCATTCTCCACACCTACTACAAGTTTGATTACAAGGCCCATCAGCGGCAGCTTAC

GCCCCCTGAGGGCTCCTCAAAGTCTGAGCAAGATCAGGCCGAAAATGAGGGTGAGGACTC AGCTGTGCTGATGGAGAGACTGTGCAAGTACATCTATGCCAAGGACCGCACAGACCGAAT CCGCACGTGTGCCATCCTCTGCCATATCTACCATCACGCCCTGCACTCCCGCTGGTACCAG GCCCGGGACCTCATGCTCATGAGCCACTTGCAAGACAACATTCAGCATGCANACCCACCA GTCCAGATCCTGTACAACCGCACCATGGTGCAGCTGGGCATCTGTGCCTTCCGCCAAGGCC TGACCAAGGACGCGCACAACGCCCTGNTGGACATCCAGTCAAGCGGCCGGGCCAAGGAG CTTTTGGGCCANGGTCTGCTGNTGCGCAACCTGCAGGAGCGCAACCAGGANCAGGAAAAG GTGGAGCGGCCCCGGCAGGTGCCCTTCCACCTGCACATAAATCTGGAACTGGTTGGAATG NGTTTACCTGGNGTNAGCCATTGNTCTGGGGANATCCCTTACTTGGNCCCCCCACAAAAGT

GACCCCCCCCNACCCATGATCAAGCAAGCCANTTNCATTACCCANTTGNGGGTGGGCCAA ACCGGAAACCαSfTTTNTTGGNCCCCCCTTGATTCCATGAAGGGAACATGGGGGTTGGTTG CCTTTTAAGGCCCTTTAAAAATGGGCC ATNGGAAAAACCπ^

TTCATTGGGAAAAAAAAAAAATGGGGCAAAAAGGGNGGGGAACCNTTTTTCCCGGGNG

NACAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCGCCCGGGCTG CAGGCTGGTGATTCTTAATGATTTGAAGTCCATTGCTTGGGAGGAAATTCCACCACACATT CATGCTTATAATAAGCTGGGGATTTTTGTTTGTTTTTGCAAATGCTTGCCCCTACTπ CGATTTTCTGTTCGTAATTCTGAAGAACCAAGGTGGGGAGCAACACAACTGATGGAATAG

TGGTATAAGTTTATACCAGAAGCTTAATGACAAGTTTTATCAATCAGAATAATACTTGGTT ATGGAAGTGACTGATGCTAAATAAATTCTGAGTATTTTTTATTAGATAATTTCTCACATAT AGACTTAAACTGTCAGCTTGGTAGTGTCTATTAGTTAAACTTTGTAAAATATATATATATT CTTGTTTTTCCATTGTATGCAAATTGAAAGAAAAAGATGTACCATTTCTCTGTTGTATGTTG GATTATGTAGGAAATGTTTGTGAACAATTCAAAAAAAAAGATGAAAAAAATTCCTGNGGA

TGTTTTGNGTAGTATCCTTGCCATTTGTATTAATAGTTAAAGTTCACTTCCAAATAAAACTC CCATAATGCTAAAAAAAAAAAAAAAAAAAACTNNNGGGGGGGCCCGGNCCCCATTTCNC C^TATAGGGGGGGNNNNNNNNNAAANNNNTSπSINNNNNNN^ NNNNNNNNNNNNNNNNNNNNTSINNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNrøπSENNNNNNNNN^

TTNNACAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGATCCCCCATCCATGAAAGCTAAGCCAAGGCCACCNGCC TTCATGATGCACNACNCGGTGNGAGTCAAGCCCGNGCATCCACGGCTACTCACTTCGCCN NAGCCTCACGTATGANAGCTGTGGNCAACATCTTCACAAAACATAGACCAAGANGCATTA CAGAGGCTCTTCACAAACTCCGGGGACANGAAAGCAGAGGAGCGAGCAAAGATCATCTT TGCCATANATCAAGACCTANAGGAGAAGACACGAGCCCTGATGGCTCTGANGAAGAGAN

CGAANGACAAGCTTTTCCAGTTTCTGAAACTGNGGAAATATTCCATCAAAGTTCACTGAG GACCAGAGGATGGATAAGGACATTATCCAAGAACGGACATTTAAAGACCAAGTGAGTCT GTAAGACCCTGACACGCACAGCATCTTGCTGTTGCCTCGTACGTTTCTCTTCTGTCAGGAC TCCGGGACTCGGGGCAGGAGAGGAACAGAATGAACTGGTGACAAGGACTCCAACCAATT TCATTGCCTGTGCTGGTCCAGTGGAGAAGTGCTTTCNGCAAGGACTGGAAAACTCTTCCTG

CANGAGAAAGACTGGTGCTNATGTCANGAAGGANAATTCTGAACCGGNCCTTANTGGAN AAGATGACCNATGGCTTGANAAAGGACTTGCCCCCAAGGTCTTCCCGGGCCNGGNCCTTG GGCTGGAAATGGACCCNGGAACTTTTTITTNCCTTAAACCCAAATTGGNAAANNTNAATN GGGGATGAA(^TTTCAAGGGGGGAATAAAAAAAAAAAAAATTNGGTGGGGGGNANTGGG CTTTACTTGGGGNTTTTTTTTTTTTGNAACCCGGGNCCNGN

NNCANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCTCAACCAGTCTTAAAAATGACACTGATTCATAAACGATCATGACCATTCCATTTA TCCTTACTATTTAGAATACACTATATTGCCTTTTTACTCTCAACACAGGACGTATTGACACA

TGTTGGAATTTTCAAGATGCCTTGTTCATCAGTAAATAATCTGACACAGACTTGAAATAAG CTCAGTATATAAGTACCCAGTTCTTACCTGCTTGCCTTAAAGGGCTCTCGGTCGAATGGCC TTGTATTTAGAGATCTAAGTGACACCTCCTCATGTTCTCATGTAGTAGGTACGAAATCAAC TTCAGTGACACCTCAGCAGTGCTGGTTATAATGATCCTATGATGAATTTTATCAAGCCTAA TTGCGAGAGCTGCTATTTAGCAAATATTTAAATTGCTCAGACTGAGGGAAATAATTTTCTG

GAGTCTTCAAAAATAAATTACATTCATTAAAAAAAAAATACATTCATCAACAACAACCAC CACTATACTTTAAGTAACTTGACTGGTAGAGCCAACCCTGATATGCATGAACTTTTCATTG GGNGGCAGGCCATAAAGCCACTTGTTTCAAAAGAAGAGTCCTATGAAGACACGATAGCAC TATTTTTNCTGAAAATGCAGGGGTCNCTTCCTAGCTGGTGGAGCCTGGCGATGGCATGTGT AAAGCAAAAACCCTGTGCCCCTCAAGGNGGGGGGGCNCAAAAAAAAAGGGAATGGGGA ACCTTGGTGGTTΓCANNAAAGNNNANGGGATGGNTTTTCCCTTTTGGGNGGGGNCNAAAT TTNAAANCNCCTGGNTTGCCNNCCTGGGGGANGGGACCCCCCNNTTNNCCTTGTTTTTTT^ NOSINCCCCGTTTNCTTTCNGGGGNNGGGAAAAAAAAAAANGGANANNNNGNTNTGGTΠ

TTNNGAAAA

GCCCTATNTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGAANAACTANCTCAGTATCAAAAGTGGGATAAGATGAGAC GAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCTAAACTTGATG

AGCTTTCTGCTAAGCGAGAGACAAGTGGAGAAAAATCCATACAATTAAGAGATGCTCAGC AGGATGCAAGAGATAAAATGGAGGATATTGAGCGCCAAGTTAGAGAACTGAAAACAAAA ATTTCAGCTATGAAGGAAGAAAAGGAACAGCTCAGTGCTGAAAGACAGGAACAAATTAA GCAGAGAACTAAATTGGAGCTTAAAGCCAAGGATTTACAAGATGAATTGGCAGGCAATA GTGAACAGAGGAAACGCTTATTAAAAGAAAGGCAGAAGCTGCTTGAAAAAATAGAAGAA

AAGCAGAAAGAACTGGCNGAAACNGAACCTAAATTCAACAGTGTAAAAGAAAAAGAAGA GCGAGGAATTGCTAGATTGGCCCAAGCTACCCAAGAGAGAACGGACCTTTATGCAAAGCA CGGGTCGAGGAAGCCAGTTTACATN^JNNAAAGAAGAAAGGGATAAGTGGATTTAAAAAG GAACCTCAAGTTCTTTANAATCAAGCCTATTTATTTGACAAAGAAAAAGAACAGATTTGCT GNTTTTACCATAANGGATTTTGGGAGGGACCACTTGGGGGCCNANATTANAAGAGAAAAA

ATCTTGGGNGCAGTNNTAAAAANACCTGGGANTTCNGGGATNTTTATATGGAAATTCCAA AGNCTCNGGGTTTGGAAGAACCTNGGACANTAAAATTTNCTTNTTGNAGTTTNAATAANT TNTTNATAGANNAATTTNCCAANGTGGGNTAATAAATTTTNCTTTGTGGNNGGAGGNAAA ANGAATNGCAGNAAACTNCCNCGGGCCCTTTGTNN

GGGNGGGGGATGNGAATNCTTNTTTNTNNANTTTNTNTTNNNNNN^

CGTl^ WTT^mTNGNTG^WCCTACTCNTATTC3 INTNTAAGGGGNGGAGGGTGGCGAGNCNN

TNNTCTTGGAN(^CCNTTGGAGA<^TNCCGTTTTTTNNACA^ACNT^ CNTNTCTTCNANNAACNTTNTNGTCANCNAANNAAATGTNANCAACACANGNTNGGATTC

NTNATTNNTACCNNCTCGGGGGTNNNATTT^

CGTTNNAGNNATACTGNATTGNNNNTATTATGTGTCTANAGGGTTANTATCGCNNAGGGA TNNANCATTNNNNTNTNNGTGANNCGGTNGANTGATGNAANGTGANGGTNNAATNTNTA NNANANAGTTCTGANTNGTGTTNNNNNCCCTNANNNCNAAGANTNTGTGNNGNNTNNNA NGATGTAGNGCNTNGNGNGTGGNGCNNNTTTGATCCACTGGNGNGNNCNNGGAGANNTN

NTTAGNAGATCNNNNTTNTNCCATNACAGTATANNAACTNNNNGGNAGGGNNGAGNNNG NGATCAGNCGANANGTNNNNNTGTAGCNCGNAGNCTCTGCNACNNANNCNTGATGNTNT NNNNTGANAGTTGNTTGGCNNTNNANGNNNNNGGGNAGGAGNNNGTNTGTNTCGATACN NNANCNOSfGTGAGATTNCGGNANTNGNNACAGNCACTAGNGNTNTANATNNAAGATATA ANANNAGNGNNATGNNNNTCTTGAGNTNNAGANNNGCGNGGAGTGNGNTTNGNATNTGN

NANTrWANTCNGNTNNGNTNGT^JNNTNN^

NGTNTCCTNNTNANGTTGCATTGATANGNGTNTAANANANNATANTNTGTCANGANTNAN TGGAGTTNACNAANNTGNANTNNNNTGGGANACNTCATNAGNTCTNCTCCCTGTANNCTA NANTCGCTNTCGANGGGANNNTCNNGGTAGTCTCCCGNNGTNAGCCNTAGNCGTAGTCTC NNGTGGNNNTAGATAGTATNANTNNGCATNNTNANTNNTNANNNGNNGACAATGTGATN

NGANGNTTGNTGTACGANNrINTGANGTGNNTGCATNNCTGAGGNNGGGTTTNGNNTACN CATGCNTNNCGNGGAATNTANCNCAGNCNANTANGGNANNATNTANTGATAATCNNACC NGTACNNATCNNTCGNTATGNGCNCAGGGCACNTNTATCGTGNGNGNGNTATCGGTANTN NAGNCGGTNGNGGATNTNTGTGTGTACTNNGCNCGCATNNNACGAGGTGTGGNGAANGT GANTCNCTGTGAGGNGTATAGACGGTCNTANTGANAGGAGACCNAGNACGCNGATGTNT

GATGNTANCAANT^WGAαNTNNGANGTATNCNACGCGGATNNNGATGTNANGNNTCGGT GANNTTTπCNNTCTNNNATNGCNC^

NNANGNNNNTTGTAGATCNCTGTAACGTNNCGATNTCGAGTTGNGGNTAGGANTCNCTGN AGTGTGTGTNNACGCG

GGGNGGGGGATGNGAATNCTTNTTTNTNNANTTTNTNTTNNNNN^

CGTTNNTT INTNGNTGNNCCTACTCNTATTasπSfTNTAAGGGGNGGAGGGTGGCGAGNCNN

TNNTCTTGGAN(^C(_^TTGGAGACNTNCCGTTTTTTNNACANACNTGACACANGGNCATN (^TNTCTT(^ANNAACNTTNTNGTCANCNAANNAAATGTNANCAACACANGNTNGGATTC

NTNATTNNTACOWCTCGGGGGTNNNATTTTTATNNAGAGCGNGTGNTTNCTCGNT^^

CGTTNNAGNNATACTGNATTGNNNNTATTATGTGTCTANAGGGTTANTATCGCNNAGGGA

TNNANCATTNNNNTNTNNGTGANNCGGTNGANTGATGNAANGTGANGGTNNAATNTNTA NNANANAGTTCTGANTNGTGTTNNTSINNCCCTNANNNCNAAGANTNTGTGNNGNNTNNNA

NGATGTAGNG(^TNGNGNGTGGNGCNNNTTTGATCCACTGGNGNGNNCNNGGAGANNTN NTTAGNAGATα WNNTTNTNCCATNACAGTATANNAACT-^[NNNGGNAGGG^WGAGNNNG NGATCAGNCGANANGTNNNNNTGTAGCNCGNAGNCTCTGCNACNNANNCNTGATGNTNT NNNNTGANAGTTGNTTGGOSπSfTNNANGNNNNNGGGNAGGAGNNNGTNTGTNTCGATACN NNANCNCNGTGAGATTNCGGNANTNGNNACAGNCACTAGNGNTNTANATNNAAGATATA

ANANNAGNGNNATGNNNNTCTTGAGNTNNAGANNNGCGNGGAGTGNGNTTNGNATNTGN NANTNNANTCNGNTNNGNTNGTNNNTNNAGNNTNTNCNANATTNNNT^^ NGTNTCCTNNTNANGTTGCATTGATANGNGTNTAANANANNATANTNTGTCANGANTNAN TGGAGTTNACNAANNTGNANTNNNNTGGGANACNTCATNAGNTCTNCTCCCTGTANNCTA NANTCGCTNTCGANGGGANNNTCNNGGTAGTCTCCCGNNGTNAGCCNTAGNCGTAGTCTC

NNGTGGNNNTAGATAGTATNANTNNGCATNNTNANTNNTNANNNGNNGACAATGTGATN NGANGNTTGNTGTACGANNNNTGANGTGNNTGCATNNCTGAGGNNGGGTTTNGNNTACN CATGCNTNNCGNGGAATNTANCNCAGNCNANTANGGNANNATNTANTGATAATCNNACC NGTACNNATCNNTCGNTATGNGCNCAGGGCACNTNTATCGTGNGNGNGNTATCGGTANTN NAGNCGGTNGNGGATNTNTGTGTGTACTNNGCNCGCATNNNACGAGGTGTGGNGAANGT

GANTCNCTGTGAGGNGTATAGACGGTCNTANTGANAGGAGACCNAGNACGCNGATGTNT GATGNTANCAANTNNGACNTNNGANGTATNCNACGCGGATNNNGATGTNANGNNTCGGT GANNTTTTTCNNTCTNNNATNGCNO TSFANNT^ NNANGNNNNTTGTAGATCNCTGTAACGTNNCGATNTCGAGTTGNGGNTAGGANTCNCTGN AGTGTGTGTNNACGCG

TTNANNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCAACAACTGGAAAGGAGCGATGATGTTTAATTGTTTTGTCCCCCCAAAAGT ACAATCTGCTGCAGTTTATGACAGATAATTTAACAAAATATATATATATATATATATATAT

AAATTGTATATAAAGTCTGTCTGAAACATTTCTTGGGAGGTGTTTTTTTTTTTTGGG GGGGNANNCTTTNNAAAAACCNTNNAA<^TTΗ^^

NNAAANACNTTTTTNNNNGNAAAAGGGGGNCCNCCCNTNTNAAAANGGGTTNGNCNTT^ TTTGNAAANTTTTNNAAAAAANGGNANTNGNNCT^^

NTNAANTTCCNAGGGCCCCNTTNNAAANNCCCCCCCNNGGNTTGGGGGGGNCCCCCCCGG NNTTTTNAANNCCGGGAAAAAAACHNGCCCCCAAANNTGGGTTTNCTTAAGGGGGGNAN TTTGGGGAACCAATTTTTATTAAAGGGNCCCCCCAGNTATTTTTTTπ AANANAAATTTNCTTTCCCTTTTTTAACCTTTGGNTTTNGNCCCNAAAACCC NTNTGGGAAAAACCNGGGTNATNTAAAGACCAACCCGGGNTTGGGNTAATNAAAAAAAA

AAGGGGGGGTTTCCTTTTTTTCαSTGGGGGNTSINAAAACCCCCCCCCCCTTTT^ CCCriTTTANCCCNCCNTTTTTTTNAAAATTTGGTTTAAAAAACCCCGG TCCCCCCTTAAAAAAAAAAAAAGGGGCNNGGAAAAAANTTTTCT^

TTGAAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCT GCAGGCGGAGGAGCAGAGGTAGNGGATGAGATANAGCTGCTGTGTCAGCGCCGGGCCTT GGAGGCCTTTGACCTGGATCCTGCTCAGTGGGGAGTCAATGNCCAACCCTACTCCGGATC CCCAGCCAATCTGGCTGCCTACACAGNCCTTCTGCAGCCTCACGACCGANTNATGGGGCT GGACTTGCCCGANGGGGGCCATCTCACCCACGGCTACNTGTCTGATGTNAANCGGATCTC

ANCTACATCTATCTTCTTCNAGTCTATGCCTTATANGCTGAACCCCCAAACCGGCCTNATN GACTATNACNAGNTGGCACTCACTGCTCGGNTCTTCAAACCACGACTNATCNTAGCTGGA CCAGGGCCTATGCTCGNNTNATTGACTACGCCCGCATGANAGAAGTGTGTGACNAGGCCA AGGCACACCTNTTGGCAGACATGGCCCACATCANNGGCCTGGGGGCTTGCCAAGGGGATC CCCTAACCCTTTAAGNACGCGGATATTGTCACCACGACCACTCACANGACCNTTNAAGGG

GCCAGGTCAGGACTCATCTTNTACCGGAAGGGGTGCAGGCTTGNGNACCCCAAAACTGGC CGAAANAACCCTTAACCCNTTTGANGGACCGAATCACNTTTGCTGGGTCCCCTTCCCTGGA GGGGGGCCCCCAAAACCTTGCCATTGGTGGAAGGGGCTGGGGNCCTNAAGCAGGCCTGG WCCCCCCTTTTCCGGGGAAGACCTCCCTGGAAAATTTNAAAAAACCCTTCAGGCCCATG GGTTAAAGGCCCTTGTTGGGACCGAAGGCTACTCCCTGGGGGGTTNGGGGGGCCCTGGCC AACCCCCCTANGGGGNGGGGGNAACCCTTTGGGCCNAAAGGGCCG

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGTTGGGTCCTTTTCGGGACCCCCACCCCTCCAGGCCCCTCTTTGCACACTTCTT CCCCCCTCCTGCCCATCTTCCCCGCACTGCCGTGCCAGGCCTGGAGGTGGTGGGGTGGGTA GAGGCTCAGCCATTACCATTTCACACCTGTCCCAGAATCTGATACCCTGCAGAGGGCAGN GACCACGCTGTTCTCCGAATGAGAGNCTTTCCCACAAAGACCTGGTATTGGGAACATCCCT CTCCTTGCCTCCACTTTCCCAAGGTAAACCCCATCCTGAAATCTCTAGCCTGGGGAGGCAG

AGACCCTGCAATCCAGAGAACACAGCCTCAGAGGTGCTGGAGGAGGGACCCTGGGGCCT GCATAGGCCACTGTGGCCTCTGCTGTCCTCCTGGGAGGCAGCCGTGTCTCCCCAGTGGGGC TCGTCCCTTCGTCACTCACACACTTGGGCCTGCTCCACTGACATCACAAGTCTTCTCCACGT GATGGTTTAAAAGGAATCGTTTCAACAGCAAAGAAATGGAGGTGGAGACAGCGCTACCCT GAGTGACACAAGGAACGGCCCGNTGGCTGACCCACGTCCGGGCCTGCCCTTGTTGNCGTG

TGGCGGCTTTAGAGTCCGATGGGGCANGGANGGCNCANTGTNCCANCACANGGGTCTGG AAGCCGTTTTCAANCCTTTTGNTTNCCGGAAGGTTCTTCTTNCCATCCGGGTAACNANTTC TGTCCTTTGTCCCGTCCCCCAAAAGCCTTTGNAGG^ TTATTTTACAATTGAATAANAAA(^TAAGGNCCNAGGAAAAAAAAAAAAAAAAAAAATT NGGGGGGGGGGNCCGGGNNCCAAATTTCCCTTTTTNT

TNNNNAANACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCGACAGATAGCCGTAACTTCTGTGCTGTGCCAGCCGCATC CCTGAGACAAGATGGTGAAGGTCGGAGTGAACGGATTCGGCCGCATCGGGCGCCTGGTCA

CCAGGGCTGCTTTTAATTCTGGCAAAGTGGACATCGTCGCCATCAATGACCCCTTCATTGA CCTTCACTACATGGTCTACATGTTCCAGTATGATTCCACCCACGGCAAGTTCAACGGCACA GTCAAGGCAGAGAACGGGAAGCTCGTCATCAATGGAAAGGCCATCACCATCTTCCAGGAG CGAGATCCTGCCAACATCAAGTGGGGTGATGCTGGTGCTGAGTATGTGGTGGAGTCCACT GGGGTCTTCACTACCATGGAGAAGGCTGGGGCTCACTTGAAGGGTGGCGCCAAGAGGGTC

ATCATCTCTGCACCTTCTGCCGATGCCCCCATGTTTGTGATGGGCGTGAACCACGAGAAGT ATAACAACACCCTCNAGATTGTCAGCAATGCCTCCTGCACCACCAACTGCTTGGCCCCCCT GGCCAAGGTCATCCATGACCACTTTGGCATCGTGGAGGGACTTATGACCACTGTCCACGC CATCACTGNCACCCAAAAAACTGNGGATGGCCCCTCCGGGAAGCTGTGGCGTGACNGCCG AAGGGCTTGCCCAAAATATNATCCCTTGCTTNTACTGGCCCTTGCCAAGGNCCGNGGGCA

ANGNC(^TNCCTTGACTTAAANGGGAAACTTAANTGGCATGGGCCTTTCCGGGTNCCCAA TTNCCAAANNGGTTTGGTTGGGGGATTTGACCCGGCCCNCCTGGGNAAAACCCTGCCCAA GTTTTAA

CCTATCTGGAGCTCCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGGTGAAAATTAAAGCTAATACTTGCTTAAGTGCTTATTATGTGC CAGGCACTGTCCTTTATAAAATTTGACTCATTCAGTGAAAAATATATTATTTCTAAGTGTT GTGTGTGTTCTCTGAGGAGGAGGAGGAACAGAGAGAAGGTAAGGCTGGAATCAAAGGTT GGTGCTTCAAGAAAATGACTTCTAAATCGGTGTTTTTCTCATCTTAATTGGTGACTGTATTC

CTGCCATCTATACATTAGAGAGACTGAGTTAACATGACTTCCTGTTCACTGTGGGTTCATG TCGTCAGCAGAGAGCATGCAGTTTGGGCTCCGACTGTACACCTGGGGTTACTGGTCTCGG GGAAGTGGTGTGAAACAGAATTCATACCAGGGAGCCCTATAATAACCATATCGGGCACTT AACCACATGCCAGGCATCCTAGTGAGTGCTTCACATGCGATACTTTGTTCAACCTTTTGAC TGCCCTTTGAGAATGGGAATCTTCCAGCCCCAGGCTCAGGTGAGGAAAAGGAACTCAGTG

ACACGACCAAGGACTTCCTCCTCATAAGGTGGGGAGAGGACCCCTTAGCCCCCAGGACAC TGATGGACTTGCCTTTCCCCTTCCCAGACTGCTTTCTTCGGAGGAAGTGTCGCTCTGTGATC CAGGAGCAGGCTGCAGCCCTGGGCCTGGNCATGTTTTCTTTTCTTGGNGCCGACGCTTCAC CTACTTACTGGAANGAGTCGGCCAAAGCTTNACTTGTCCTNTCCTGAGGGGAGANGGAGG ATCAANGATGACCTTCAAGGNGTCCTNCTTTTGTCCCGGANCCTGNAAGGAACTGCTCCCC

CANNGNGAANGNNTNGCCAAAACTGGATGCTCGGGCTACCCAAACCCTGGAACCCTCCCC TACCTTCCTGGGACTGCCCTACANGG TTGAGNCNATNTGGAGCTNCANCNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCNGCACGAGGATGNCNNCTACGNNNCCCAAGGANCTTGTCTNGCTGTG GGNCTGAATAACANNTTATTCCTGCANAAAGCGGGCANNGGTTGACTNCANTCNCAAGAT AACACGNGCGCNCACCTGNCTGATNTNTGANACCGACCTCTGANTTAAGACTGNCGCCAC ANCNACNTGGNTTNCNTGGCNNCTCCNCCTNGCTCCTCAANANNANCCNTTCCTGNCAAN

ATCCTNGTANTTNGAATTCAACT(^AAANGGNATTGNTNGA(^CCNTTTNCNATCTCAGA CTTTTGNNTTTNAATGGOSINNNTATCCACTGANNATANTATTNCCCTACCTCNCNTTA^ TGAATATATATTNTCNCTGTΑWGNTATTNTTCTCCTCNCTGATCTAAAANACNATNCNTN CCGATG(^TAAATGTCNNTCCTCATGCTNNNANACCTNGNTTTNATNGGAACNAATNTTT NTNGTNATNTCCNNAGNNTTNCNN^

TTTCNTRAATAGGGAANNAANGCATGNNNNTTTAAACTTAATTCCGGNNANNCNTRCCMNF NNAATCACCTAATCTNGAANTGNNACAAGTACNCTAGAANGCTNGGGCANAATTTANATN CCCAANACANTTGGNGCTCTAACCACNNCANGTCAAGGNNCATTANNCNCNCTAAATGNA CTTACTNNGNCCAANGAGTONJNNNNNNCANCTNTACNGNATNACAAGATNNTNGNNCCN GTGNNNCNTTNCNNANO^TGNGNNTNTNNTGGGTCATNCAANACTCNANGCGTCTCTTCT

ACCTCTNGCTNTTCCCTTCNTSFNATCTGNTNCANNCANTNATCCCTANTNCNRWGNTNNTCT TTTTTTTTGNNANTAAACCCGGAACTNTCTAGTTNCACCTCNCCNNTTNCNAANTAA TTCANTAACTCTCNTTTCANCTCANNNGNNCTTT MGCNACNTCNTGTCNACNCNTATTAT TCCCNNTNCNCNAGTTTTCNNTCCN

GCCCTATANNGAGNCGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGGTCATGTTGAGCCTGGAGTTTGATTACATGTGCCAATATGA

CTATGTTGAGGTCCGTGACGGGGACAGCAGCGACAGCCAGATCATCAAGCGTTTCTGTGG CAATGAGCGGCCAGCTCCCATCCGAAGCACGGGCTCCTCACTCCACATCCTCTTCCACTCA

GATGGCTCCAAGAACTTCGATGGCTTCCATGCCATCTTTGAGGAGATCACAGCGNGTTCCT CGNCCCCTTGTTTCCACGATGGCACTTGCCTNCTTGACAGCACCGGATCTTACAAGTGTGC CTGCCTGGCGGGCTACACCGGGAAGCACTGTGAAAATCTNCTTGAAGAAAGAAACTGCTC ANACCCTGGGGGGCCAGTCAATGGGTACAAGAAAATTACAGGAGGCCCTGGGCTTATCCA TGGGCACTATGCAAAAATCGGCACCGNCCTGACCTTCTTTTGTAACAGCTCCTATGTTCTC

AGTGGTAATGAGATGAGAACTTGCCACCATAATGNANAGTGGTCNNGGAAACAAGNCCN ATCTNGNATAAAAGCCTGCCGNGNAACCAAAGAATCTNCAGACCTGGGTGGAGACNGAA AGTTCTTTCCAANTGCCAGGTTCACTCCAAGGGGAGAACNNCCNTTTACAATCAGNNTNTT ACTCATTNAGCCCTTCTACNANANCANNAAAACTGCNNGGATGCCCNCNTACCCAAAGAA ANGCCANTNTTCTTTTCCCTTTTGGGAAGAACCCGGCCCGCNCTNGNGTTCCCAAACATNT

TGCMΓCACCCCCNNTΓANTCCANGTACCNAGGTGCTNTCTATCACCCCTTTTTΓTATTCNG CCCGACCTTGGGGCANCTAANCNCCCGNANGGACCATTNTTTTTANGGGAACTNGGTNAA NATGGGANANGCGTCCNTΓNNCCCCCATACCC

TNAGNCCTATAGTGNNGTCGTATTACAGTGGCGGNCCGCTCTANAACTAGTGGATCCCCC GGCCTGCAGGAATTCGGCACGAGGATGGCACGTCCCCAGTGGTGGGGATGTGCCGCGCTT CCTGANTAANTGGAATTGGNAGNAGTGNCTGCCOSINTNNNGNNTTTNNTNGGNAAAAAG GTNNCNCCNNTTNNNATNAANNNTTTNCNNGNNNNNAAANNNN^ NGNNGNTTTCCAAGGGNAGGNNCCTTTTTTTNNGGANNTTTGNACNCTTNGNA

GCCTGTGTANTTAACCGGTGGGAAGNCTTGNGNGTTGNGCATTCGTNCTTGNGCACTATAT TTGCGCCTGCGCTATGNGCACAANAGAGCCTGTGNCTGTTNAGGCGCCTGTNTTTTCANAC CCANNTNTGNGACANCAAGTGCNCNACANGNTNTCAGGGNTNGGNGTGTNCANGANNCC CCTCTATATATGNNTTTGCGNGCGNCNTGGANNACCCACACCCCTATAGCNGGNGTGATA NGCGCTGCTNNTANCAGANNAGGGNCCNCCAGTGTAANNTCTTTGAAGGNGANCCCNCCT

CCNNTCTAACNTTCNCCTNNTGTAGAGNGCGCGGTGGAGATTCCNAAAGAGGCANAAAN N<-^TGNNGCTNGGTTNGGANAATOSFTCTGNTTNCNNTCGNTNCTTATTNANGTGNCCNT^ NNGCCCTCNTTNAATCANANNATNNTNTNNTTAACNNNCTTTAACCANCTNNGΠ GNGTTCCTGGTTNANTTNTCTATAAAANTCNTNNTNCNTAGNGAAANAAAAATGNGNNAG AAACNACCGGTNNAGNNCNGCCTTNTTTTCTOT

TNNGGGACGGAANNANCCTNTTCTTTCCTCCTNNTTTTTNCTANNGNTAAGTCTATATTAA AGCCCNCNNNCCTTCCTANACCNNNTCCATGTCGCCAANATNACACAACCG TNAGNCCTATAGTGNNGTCGTATTACAGTGGCGGNCCGCTCTANAACTAGTGGATCCCCC GGCCTGCAGGAATTCGGCACGAGGATGGCACGTCCCCAGTGGTGGGGATGTGCCGCGCTT CCTGANTAANTGGAATTGGNAGNAGTGNCTGCCCMvrTNNNGNNTTTNNTNGGNAAAAAG GTNN(^CCNNTTNNNATNAANNNTTTNOSINGNNNN^ NGNNGNTTTCCAAGGGNAGGNNCCTTTTTTTNNG

CCNNTCTAACNTTCNCCTNNTGTAGAGNGCGCGGTGGAGATTCCNAAAGAGGCANAAAN N(_^TGNNGCTNGGTTNGGANAATOSITCTGNTTNCNNTCGNTNCTTATTNANGTGNCCNTN NNGCCCT^TTNAATCANANNATNNTNTN^ GNGTTCCTGGTTNANTTNTCTATAAAANTCNTNNTNCNTAGNGAAANAAAAATGNGNNAG AAACNACCGGTNNAGNNCNGCCTTNTTTTCTNTTNCTTNNGCNNAAGTANCTN^

TNNGGGACGGAANNANCCTNTTCTTTCCTCCTNNTTTTTNCTANNGNTAAGTCTATAπ AGCCCNCNNNCCTTCCTANACCNNNTCCATGTCGCCAANATNACACAACCG

TTGANAANNTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTNACTGCNAGGGNGNNACANGGNNNAANNCATCGGACCCTCNNTANGG GACTGGTGGANCTNAACTCTCTGNGANGTGNCAGATTGGNACTCTTCTNNCTANACATGT ATANCNTGAGANAGCGGNTGCGGAANAACACGGCACGTGCANGCGGACTCCNTGTTNTT GCTGCAGGGTGGNNAGGAGACGCAGCGCTACTGCACCCGACACCGGNTTGCTTTTCCGCC AGGAGTCCTTCTTTTAα^TGGGCATTTGGTGGTCACCGAGCCGGCTTGTTACGGNGTNGAT

CAACGTGGACACCGGNACGNCNATTTTGTTCGGGCCNAGGCNTTCCTCCANNCCNTGCAA CTNGGATGGNAAAAATCCATNCCANGGACNCTTCAAGGAAANNTCCGCCGNGAATNNAT GTCCAATCCNCAACCAANAATTGGCCGNGGTTNTGGCNTTTTCGNAANCCCCTNNTGGGN GGCNTCCTTTCNAGGGGCCTT NACTAAGGTTCAATTGGTNAACAANNCCCCTTTTNTTπ

ATCAAAAAAATNTGGGGAAGTGGCCGGTTTNTTTAANANANCGNCNATTGGNACCCTTGA AGGNTTTTTNGCCCNTTANNOSTCAAAANAAAAATTTTCCATTNGGGGGCCCCNCCGGNAN GNTAAATTGAAGGTTTTTTAAAANTNNGGGAANTNAAAAAAAATTTTGAANATGGGAAA GGCCCTTTTTTAAAAACCATTANTTGNTTANNTTCCCGGGGGGGNGGNTNGCCCCCTAAA ACTTC<^TNCC^CTCNGCTTTTTGGGGGNAGNNGGGGGNAAAAAACTTGGCCCGGNNNTN

GAANTNANNGAAACACCCTTNGGGCCCCCCCANNGNAAAAAGAACCTTTTCCAAAAAGG GGNNAAACTTTNGCCCNNTTTCCAAANNNGGGNNGGGGANT

TTGANACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGCAGGATCAAGCGATTCCTNCCAAGAAACAAAAGCAGAATCGTCCCATNNCTCA ATGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATTGGA GAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGTCTTAACATG ATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCAATAAATATAAAACGTTGCAAAAA

AAAAAAAAAAANNNNGGGGGGGGGCCNGGCCCCANTNCCCCNTTNNGGGGGGCNGTTTA

AAANNOSiNNNNGATαsπsrCNNACCNNNNCNNTANNNGCCTC^CNNNCCNAT^

NNNCANNNNCCCTNNCrø^CTTTNTTTCTTNANNCTNNNTGNNGGTNπ

NrøTTTANTNCNmπsπ TTTNC^ TACNNTTTNNCTNTTTTNNTTTNGGNCCNTATTTNTTT^

TN1^NNNNTNCTTNGG]>JNNTNC^^^

CATTCTTNNNNNNNNCTNNNTNNTNTTTNTNN^

TNCCITTN NCOlNTT ATTNC ^

NTTNNTSINNNNCTCNNTNNNGCTTN^ ANNNNNNNNNNTTTTTTNNNTNTTTNTNNNAT^

NCCNNTNTNNTTTTNNTNGGACCCG NNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGTAAAAGTTGTTCTTCCTTTGGCTGGTAAAGTAACATGTACAACACTGATTCCTGC TCTGTGTATCAAGGAGACATTGCCTCTGGCTGAATGAAGCAGGGTTTGTGAAAAGTGCTC AGAAACCAGAAGTTCCCTGTGCTTTCACAGCTTTTGAGGCTTTTCCTTTTCACACTGGAGA CTTTCTTCTGTTTTTAATGTGGCTACTGTGTGGCTCAGAAATGGCTGCTGTGATGAAAATG

CTCATTTGTTAGGAAAAAGAGGTAGCTACATTCTCATTTTGAAAGGACCATGAGCTATTTA AAAAAAAAACCTAAGATGTGGTTTTATTTACATGNCAGGGGAGCTCTTGATCATGTTCNC ATTGTTTTAAGATAAAGCGATTTTTTTTTTCCTGCTT^ ATATTTTTATCATTAAAGGTCACTATAGTGTANNAAGGTNTGCTGAACCGTAGNGTTAGTG ANNCCCAAAGTAATCCNTAGTAAAAGAGCAATATTTTTCTGAAGCTGGGATCTGGGTAAT

ACAGAGTTGCTACTCAAAAATCTAATAAAGCTCTTACTTCGTATTGGAAATTATAGAACCC TTCCTTTTTAAATAAAAGCCCTTTTTTTTTTTAAAA^

GAAAAANGCCTAAAAAAAAAATTTCCCCTGGGANTTTTGGGAAAAAAACCATCCTNTAAA AACCTTGGAACCCCTGGNAAATTCCTTTTTGGCCGGGGGCCAAAATTCCNAAAAACNTTT NTAAATTCC(^AAAATTTTTTGGNGGGGGGGAACCCTTTGNTTTTTN

CNAGCCNGGGNAAACAATCCANNGGGNTTTTTTNAAAAAAAAANGGGAAACCCTNNTTTT TGTTN

TTGAAACCGCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTNNGCACGAGGCANTGNCCGTCNCGATGTTGNTGCCTAANANNANCCGGATT GCCATTTATGANCTCCTTTTTAANGAGGGGGTGATGGNGGCCAAGAAGGATGTTCACATG CCCAACCACCCGGAGCTATCAGAACAAGANTGTGCCCAATCTTNACGTCATGAAAGCCAT GCACNCTCTCANNTCACAGAGGCTACCNTGAATGGAACACGTNTGTCTGGAGACATTTGT

ACTGGGACCTNACCAACGTAGGGNATCCATTATCTCCGTNGATTACCTCCACCTGCCCCCT GAGATCGTGCCCGCCACCCTGCGCCGGAGCCGTCCTGAGACTGGCCGGCCAAGGCCCAAA GGTCTGGAGGGAGAGCGACCTGCAAGACTCACTCGAGGGGAAGCCGACAGAGACACCTA CAGACGAAGCGCCGTGCCCCCTGGTGCCGACAAGAAGGCCGAGGCCGGGGCTGGGTCAG CAACTGAATTCCAGTTTAGAGGCGGATTTGGTCGTGGACGTGGTCAACCCACCTCAATGA

AGTTTGAAANGGGATTGGTTTGTGTTGAATAAACCTGTAAACNNGAAGAAAAAAAAAAA AAAAAAAAAANGGGGGGCCCGGGACCCCAATTTNCCCCTTTTTTGGGGGGN^ NAANNNNNMNNNNNTNNNNNNTNNTTNN^ NNTNNNNNNTNNNNNNNTTNNNNTNTNNTNN^ TNNNNNTNNNNNNNNNNNNNNNTTNTNTNN^

NNNTTNNNNTNTNNNNNTN^ NNTNNNNC

GGGTNNGNGGCNNNTNAAATO^MNTNNNNNNNTSπSlTCN^

CNTTCTNTTTCTTTCTCTNCCCCCCCCO fAANGGNNGANGNATGAGTAGATTGACCNNCTT TTGAAGNCNNCNNTGGAGNTGCATCACNGNGNCTACCTTTNNCNTGNTCTTNTTGTCCTTN TCCTCCCANCACAATTCCACNANATNATTANATNTTCACATTACATNANGCNAATCCNTNA TTANACTTCNNGGGCCTCMsTTCTCTCACGNCTT^ATNCTNCCTCCTNATACNNTTNACCGC

CANCACTNN(^TNNCANCNCATACTANNCCAANNTNNCACTNCCCATATNNCTGANTTTN ATNNANTTTACATNGTNTTNNNAAATNTT^

TNTCNCNTTANCATANNTCATCTANTOsfCTNACNNTCATNTTACGCTTNGTTNNNCNACTT

CTATCπCNNC TNATTNAC^TAπCTNA TTACTNNTNNGNCTNTTGTNNGCGACAANCTO^

CNCTANONrt^TTANNNCTNNTGTNNTCCTANNTNNTAATCTTANN^ CTNGNGNTANACATAOWCTTTAAAACCCTNGANNNANCTNTNCTANAACCTCACNTCNC

CTCTNNNAANCMSINTNCnsrGNNNAAGNNAGAANNNAANTNGCNTNTTT^ ANNNCGANNCTAAGNTAANCT>WTATTNNNANTNNGANACAATNTNNGCGNNATCNAAT ANACTNNCTTNCTNNACAGGGNNTCTAGCAANNGCGGCTGNTTAACACGNNTGTNNANA

NTNCCANNCTNTGANAATNAAGACNACTANNNTCATNNAOS1NNTTNGNNCACNACACTCT

NTTNτ>!NNCAGNTNαSINNAGN(_ C^

NTNTTNNGATACNNCNCNANAANCTNT^

TANTANαsπSINNNATNNCNNTGGNNTNCGCANANAGANCTCATNNTCTOSfCNTNGNNTAN f AGTNNTGANNNANCNTATATCNCNCNATCNCGACGTGCAAGATANNNCAANNNANCAAN GNNCNNNTNCTGATCTCACNNANANNGACGCTNAATANNCGNTATCTNACTCTCATTCGN GNTNNANCNCATANNTGCNCNTNNGACNCACNAN(^ANNGATNANANTNNCANNNNTNN NNACNCNANANANTTGANCACNCWNGNTATACTNANACNANACAGACNNGAGCGTCTAN ATTGTNATANACGACACHNNGATCGANATANNNOSfCGNGNANANNTNTCNNNCGANTCA

CATTNTGTTNNACACGANACATNTAANNACACNCGTCGTGACTGNCNNGTGTCGNCACGA NTATCGNNANANACNANTCTACATATATGTANACNCGACNCACGTACACNNAAGACANG NGNNACNTGANTNCNTCATATNTCGANNCNANNCTAAACNAAANGANACNATANGTNAC GNGACNACAT(^ACTATTNTACANGATATNAGNTGCCGTTAAANACTCNATGTNTTNNGN CGNTNTNATNATGNCNC

NCAANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAAATTCGGCACGAGGATGGCACGTCCCCAGTGTGGGGATGTGCCGTGCTTCCTGA ATTAGTGTATTGTAGGAGTTGCTGCCCCATTCTGCTCTTCATTGTGAGAGAGGTTACACCC

ACTTATAATCAGTATTΓTCCTGGCACTAAAACAGCAGGGCTGGTATTTGCTGCTGCTTTCC CAGGGCAGGGTCCCTTCTTTTCGGCACTTTTGAACACTTGCAAGACACAGCCCTGTTATCT AACGGGTGGCAGGCATGTGTGTCTGCACTCGCTCTTTGCCACTATTTTGCCCTGCTCCATG CCAGAGAGCCCTGTCCCTGCCAGGCCCTGCCTTCCCAGCCCCAACTTGGGACCAAAGTGC AAGACGGGATCACAGGTTGGGGTGTCCAAGTGACCCCTCTCTATAGTGCTTCCGTGGGCC

AAGTCGACACCAGCCCCCTANCGGGGTGGGATGGGCGGTGCTTAAAGAGGAAGGGGACC AAGTGTANCAACTTGCCAGGGACCCCACCCCTTCCTCACATTCGGGCCTGTGCAAGTGGG CGTGGGGATTCTNCAAAGGGGCCAAANGCCTGGGCTTGGTCGGNATTCTCTGCTCCTTGCT CTTATCTGGGNCACATGCACACTTCTAAATGCANAATTGCTTTGAACTTTAAAACTGGTCA ANTTTGGGTTTCGNTTTGGGACCGAATTTAAAAAAANGTTTTTANTNGGGGGAAAATTTG

GGGGGAAAAAAC<^GGGGNNNGGGNCC^GGTTTTTΓTTTTTTTT^ GNCNNTTTNNCGGAGGAAACCCOTTRITGNTNC^^ rWTNC^CCCCOSπSINNAAANCCN^

NNTNGGGGGGCGGGNNNGNTTTTTTTGGGNACCTTNGGGGG

GCCCTATANNGAGNCGTATNACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGNCNTGANNTATGANNCCNANCGNGTGANNCATAANNNANA GTGACTCGTGCGNNTGAANCCNG(^CNTTNAGTTTTNGNAATGCTGNCTTNAAANANNGC NNGTTCANATCTAGNGNNACAGN(^GNNNAACTNTTNNACAAANCTTATNATNTNATTCT

GANCGCCNCTATTANTNNTGNTGNANGGGANGNNNGAGNTAAATCCCTGTTGANGAAAA TTAANTAGATATTCTNTGTGGTNCNANATTAACAGGAAGGCGCGCCCGATGAATAGGCCG TTTTACTCTGCCACAAGCGTCAANCGTTAATTATACACNNAANCAGAANGCNATTTTGNTT TCCACTNAGANAAGANATATACTTTTCNAGAGACNTAACNGAAAATTATAACCATTNGNC AGAGGNCCANNCTTGAGCACCTTGNAGACNANNANCCTGGGCTCANTNTCCCCACNAGAC

CNCCTATAGTGNTTNGTNTTNGANNGGACACCAACNTGNTNTCCNACTGANCCTNCCTNA CNNTACCTNNCATGACGGAAGGGGNGGAGGTGGNNAAGNCANTANTGGANCANTGCGCN NGNAATAATTATAATANTATTTTCTTTTTTNCANCCCGTACACTTNGGGAACTTNCCTANG AGANAGGTGCNCNCCNNCGNCTTATTCCAAANGGCTCNCGGGAAAGGGNGGCCNCATTT NCC(^TCTTCCCCANNNTTGGANGGAAANCCCANANTCAANNCGCCGNCNNTNNNAGNA

CCCGGNAATTNTTNNCCCCNTTATNCTCCNTAGGNNCNCCTTNCNCCTTTCCNGGNNGGCG NTATNTTATCANN(^αSINAANCNNTNNTNTGGTC^CTTGNTCCCATTGTTCCNTNGGGNN GGTGGGAANTNNGGNCNCTCTNNGCTTTGGNCTCANTTCACTCCG

GGNGCGCGGNGNGNCACTTTCNNTTTTTTTNATNNNNTNTTTT^

NTCCTTNNANTTANNNGTAGNATCACCANNCCCANCCTAGGGGGNTCTTGGAGTNANTCT TNNCNNTTGGGNCCNATANGNNTCGNATTACANTGGTNNCCGCTCTNCANCGANNGGCAA NANαsπsrACNCTATAGNGATTTTOSrCGCNCGATGC^TGTTTTCCTNCGr^ NNNCCTCCATGGGGGNGAOSINNTNTαWNTTCTGTAT(^TTTNCTNNNCN^

GNCCNNTCCTTGACNTAATATATNNNTCNCNAGATANTNNGNTCNNNTCCAGTNCNTNCT Ca NNCNTANTATTTCC3SITATANACCCCHNTNGTNσsπSfTTNNATTNC^ NTCTNNNTGNNC(^TTCTNNNTCTTNTN(^GCCTATTNTNNCN^ ATTATTTN(_^CNNTNGNCTCNNTATC^ NNCANCTTN(^CNIWTGCGOSnsiNNTNTAGGTGNNNNNCGACTNN^ TCAAAATNCTTNNTNTTTCTCNAATTNNTNNTTCANNTTTTα^ TTTTNNANCTNTTNTNTNCTNTGN^

NATNCNNATNNCTNNATNTANNCANNTCGNTAGTNNTTCCNCNCANNTNTCGANGANCNN NTNTAANNTTNACTATNNTACTTC ^

TNNNNNCTOSINTATTGNTNGTCGCNNAANTTNNNAGTCNAAGNGANTNNN^ NNTCTGCCTCTCMsπSlNCNNCAαSINNNTNGATAATTNNNCCACATNTσ^

NTTGTNATGGANNTTAGNTGTATTAGNNGATGACTCGTNCTANTCTTTCTNTTNCGNNCCC NNTGGNCTTNNOSΓTNNNNNTGNATGAAGATNNCCCCTTTNCCCCTTNT^^ GACTGTCΑ^NNTANGACCCTCTCΑSRAGGNACCTNT⁽^ACTNTNTACTNCTCCTTCCGTTAN

NNCTNCNCCNCNTGNTNANCACCTNAGC

TCTCTNCTNCCNNTNGNCANTNNCTCAAGACCNTCATANTTNGTANTCNCCNCNATNTCNT NTCTAGNAATATATGTNCTNCTTCANAGCANNCCTGATTANCTCCGTACCNNATGNGNGG ACTNTCTATNTATGTTCTNGTNTACTATAGNNTNTNTCATGTACTTTTANTTCAACANAAN TACNCNNCNNNCNCTTATCTAGNCTNNTCCNTNAGTNNGTNTGTTCTTAAGATNACCCACC

AAAGNANTCTNNTNTCGNGATTNTGNNNATTMSINTANCTCTCTACTTTAAGCTATTNCTCT CTCNNANATACGTACNTNTCCGNTANCNNTCCC

GGNGCGCGGNGNGNCACTπOWTTTTTTTO^

NTCCTTNNANTTANNNGTAGNATCACCANNCCCANCCTAGGGGGNTCTTGGAGTNANTCT TNNOSINTTGGGNCCNATANGNNTCGNATTACANTGGTNNCCGCTCTNCANCGANNGGCAA NANCNNA(^CTATAGNGATTTTCNCGCNCGATG(^TGTTTTCCTNCGNNCGNCTNCGTNTC NNNCCTCCATGGGGGNGAQWNTNTCNr^ GNC(3WTCCTTGACNTAATATATNNNTCNCNAGATANTNNGNTCNNNTCCAGTNCNTNCT

OS[NNCNTANTATTTCCNTATANACCC(-MSfTNGTNCNNTTNNATT^ NTCTNNNTGNNCCNTTCTNNNTCT^

ATTATTTN(^CNNTNGNCTCNNTATCNANCCCNATTTNNNNTAGANCCNNTNNTAGCCNC NNCANCTTNCNCNNNTGCGOSINININ^ TCAAAATNCTTNNTNTTTCTCNAATT^

TTTTNNANCTNTTNTNTNCTNTGNATNTCNCATGATNTCTNGGNTTNTNNN NATNCMNATNNCTNNATNTANNCANNTCGNTAGTNNTTC(^Cπs[CANNTNTCGA NTNTAANNTTNACTATNNTACTTCTATCG(^ TlSfNNNNCTONINTATTGNTNGTC^ NNTCTGCCTCTCMSINNCNNCAαSfNNNTNGATAATTNNNCCACATNTC^

NTTGTNATGGANNTTAGNTGTATTAGNNGATGACTCGTNCTANTCTTTCTNTTNCGNNCCC NNTGGNCTTNNCNTNNNNNTGNATGAAGATNNCCCCTTmCCCCTTNTNNN GACTGTCCMWTANGACCCTCTCCNAGGNACCTNTCNACTNTNTACTNCTCCTTCCGTTAN NNCTNCNCCNCNTGNTNANCACCTNAGCANTNNAACTNCNGANTTATTNCTTCTNTGNNN TCTCTNCTNCCNNTNGNCANTNNCTCAAGACCNTCATANTTNGTANTCNCCNCNATNTCNT

NTCTAGNAATATATGTNCTNCTTCANAGCANNCCTGATTANCTCCGTACCNNATGNGNGG ACTNTCTATNTATGTTCTNGTNTACTATAGNNTNTNTCATGTACTTTTANTTCAACANAAN TA(^CNNCNNN(^CTTATCTAGNCTNNTCCNTNAGTNNGTNTGTTCTTAAGATNACCCACC AAAGNANTCTNNTNTCGNGATTNTGNNNATTNNNTANCTCTCTACTTTAAGCTATTNCTCT CTCNNANATACGTACNTNTCCGNTANCNNTCCC

TTTGANACNGNTGGAGCTCCNCCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNANNAACTGGAAAGGNNTNATNANGNNTAATN WTTNGACCNCCCAATGGG GACAATCTGCTGCAATTTATGACACNNTAATATCAACNNAATATATATATACNATATATAT

ATATANATNCTNTCTAANNACTATNTTGAA^

C(^ATCTCACNGANATGNATTTTTCNGNNT^ NANNNTTTTTCCACATTTTCTCTAC^^ CACNTTCTTTNNNACTNNCCTATTTAATAGTTTNTTTNAATTATCTANCT^

(^TCNGTTTCCCCTNNNTCTTNAATC^

TNANNNNNTNTSfNACCTTNNNNT^

NCCTNATNTTATAATCAACAGNGTNNNATAAATNNNACTNNGNCCANNTCCCANCCTTGT

CATCTTAANNCCCCNC^TTTTTT^ TANTTGCCNTNCCNTANCCCGNGNTACTNNTTATNAANNANNNCTTANCNTTTANCTTNTN

NTCCCTNANINATTCCOSINTGCCTNNNNTIΗCTANNNTANTNNANNNCTN^

TNTNCANNTCTNNNAA(^AANTCTNNCTAOSπSINNNNNTNTTT^

TNTC^ACCTTTCOWCTTCTACCGT<^^

TCTCGTTOStNCTCANTCNTNNCCNTNTNNCNTCTTNNTCANACTCTTTT^

ANCNINCTCfWCATNTTNNTNTNNCC

TTAANCACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGG CTGCAGGAGCTTATTGAATGAAAACTCCAGAGACTGAAAAACCAAACATGAGGGTAGCA

GGTGCTGCAAAGTTGGTGGTCGCTGTGGCAGTATTTTTACTGACATTCTATGTTATTTCTCA AGTATTCGAAATAAAAATGGATGCAAGTTTAGGAAATCTATTTGCAAGGTCAGCATTGGA TGCGGTTGTACGTTCTACAAAACCTCCCAGATATAAATGTGGAATCTCAAAAGCTTGCCCT GAGAAGCATTTΓGCTTTTAAAATGGCAAGTGGAGCAGCCAATGTGGTGGGACCCAAAATC TGCCTAGAGGACAATGTTTTAATGAGTGGTGTTAAGAATAATGTTGGAAGAGGAATCAAT

GTTGCCΓΓGGTAAATGGCAAAACGGGAGAACTAATAGACACCAGATTTTTTGACATGTGG GGAGGAAAATGTGGNCCCANTTATTGAGTTCTGAAGGCCATACAAGATGGACCAATAGTC TAATGGGAACATATGATGATGGGACCANCCAACTCAATGATGANGCCCGCGGCTGATTGC TGAATGGGGAGTACATCTATTACTCATCTTGGTTCAAAACACTGGGGTCTTNTGGGGNGG AAAAGGCATTAAAAACAAAAGCCCTTTTGACNGCCCCNTAAGGACCATTAGGGCCCCAAN

TAAATTTGAANGGATGGCCCTGAATTTTNGGAAATGGAAAGGATGCCTTTCCCCAAAACC AANACTGGCCGTGGANAAAAANCCGAAGGGGGNCCCCCNTTTTCCTTGTTAANGGGGNA AAGCCCCTTNCCCAAAAAAACTTC<^TGGTAAATNTTT^ TNNGGGGGNGNGCCCTTGTCCCCNTNTTNTNTTTTTGGAAATTCAGN

TNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGTGGCCTTCTCCTCTCCCCGCCATGGCGTGTGCTCGTCC ACTGATATCAGTGTACTCCGAAAAGGGGGAGTCCTCTGGCAAAAATGTCACTTTGCCTGCT GTGTTCAAGGCTCCCATTCGACCCGATATTGTTAACTTTGTTCACACCAACTTGCGCAAAA

ACAACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCATCAAACCAGTGCTGAGTCTT GGGGTACCGGCAGAGCTGTGGCTCGAATTCCCAGGGTTCGAGGTGGCGGGACTCACCGTT CCGGTCAGGGCGCTTTTGGAAACATGTGTCGTGGGGGCCGCATGTTTGCGCCAACTAAGA CCTGGCGACGTTGGCACCGCAGAGTGAATACGACGCAGAAGCGATACGCCATCTGCTCTG CACTGGCTGCCTCAGCCTTACCAGCGCTGGTCATGTCTAAAGGTCATCGTATAGAGGAAGT

TCCTGAACTTNCTTTGGTGGTGGAAGATAAAAGTTGAAGGCTACAAGAAGACCAAGGAGG CTGTGTTTGCTTTCTGAAGAAACTTAANGGCCTGGAATGATATCAAAAAAGGTCTATGCCT TTTCAGCGAATGANANCTGGCAAAAGGCAAGANGANAAACCCGTCNCCGTATNCAACGC AAGGGGACCCTTGCNTCATCTATNATGANGGACAATGGGTATCATTCAAGGNCTTTNAAA AACATTCCCTGGAATTACCTTTGCTTAAANGGAAGCCAACCTGAACANTTTTGNAAACTTG

GTTCCTGGGGGGGCACCGGNGGGAACGTTTTTTGNANTTTGGAACTGAAAGNGCNTTTTC C^AAAGGTTAAAAGAACCTΓTTTTGGGCCCCTTGGNGGTAAAACACCCCTCNCCCTTNAA

NAAA

TTGGAAACCGTTGGACTCCCCGNGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGTAAAAGTTGNTCTTCCTTTGGCTGGTAAAGTAACATGTACAACACTGATTNGGN

GCTCTGTGTATCAAGGAGACATTGCCTCTGGCTGAATGAAGCAGGGTTTGTGAAAAGTGC

TCANAAACCAGAAGTTCCCTGTGCTTTCACAGCTTTTGAGGCTTTTCCTTTTCACACTGGA GACTTTCTTCTGTTTTTAATGTGGCTACTGTGTGGCTCANAAATGGCTGCTGTGATGAAAA

TGCTCATTΓGTTAGGAAAAAGAGGTAGCTACATTCTCATTTTGAAAGGACCATGAGCTATT

TAAAAAAAAAACCTAAGATGTGGTTTTATTTACATGTNAGGGGAGCTCTTGATCATGTTCA

CATTTGTTTTAAGATAAAGCGATTTTTTTTTΠ

TTTACNCTTTTATNATTNGAGGCNNCTTATAGTGTANGTAAGGGTNTGCTGGAACCGTANT GTTANNGGAACCCCNANANGTAATNCTTATTTAAANGG

TNGATCTTGGNTAANTAC^AGNANGTCNGNNTTANTCNANAAAATTTTNAATAAAGCNCT

TTAANTTTΑ«NATTGGGGAAAAATTTATAA^ CCNTAANANAANAAAATTTACGN(^GGGNATTTTTTGGGGAANNATAAACCANNCTATTA AAANACCTTTGGAAAAACTNGGAANAAATTTCANTTATGGGGNTGGGNGGGNNNTNTATT CTNCAAAAAATCTTTTNTTAANTTTA(^ATANATNATCTTGNANNGNGANNAAGCCCTNTT GTCTTTTTNACTAAATANTCTTTGNCCAA^

GNCCTTΓANTTANGTGNANGTTCGGTAATTAAOSINGGGGGANTNCCTNNTNTTAAANCTT CGTCGCCTTC^TTCWWATG(^CTNGNCANGCANTCCCTTGCACCTCCCNAGANTTTCTTT

ATCCTACCTCANNNCNTGACNNGCANTTCCNANNATTATNTNGGGTATNTCCTNTATGCAC AAJSINCNNNACNTTACTNGNGTACTTATTCTNGCANNTGATCGTACCTCTTNCGCTTCANTT NANACCAT ^I^S1NNNAANTTCCNTTGCTCCCCCATTTGGNTANCTACNCCNGNNANAGATT

NTCTANATANNNTNNGTTGGCCCATANCTGNTGTTGNNCTNTATCNNNCTCAGGTCTNTGA GNATGANAATTNATNTTCGNTNANNANCGNTNGAAGTCCTATCACTTTANGTTNGNNAAG NGNNGNNCTNTNANTCAANGNNNTANNNAGGCNTGTNNNGNGCTGTCNTTCNNANNTAC GNTGNNNAGNNNANG(^CTCANGCC(^TAATAAGNNNANGGGGGTTNTNTGNNTAAANT CAGNTNGAC^ANNTNTATNTNCCNCNαSfGNCTNGGGGGCCNGTANTANNTNNACTNAGG

TTAAAATNGGNNNNGGNNNNNNATANGTGCCTACANTGANNNNTGO^AAGGNNNAOvINT TAANTATNNNGAANNAAANNNANGNGNGTNGNTNTNTAAACTANTNACAT WATTNNNN NTGNNAGTANTTCNTNNNTNCNACGAGTCGGGNNTGGNAGTNTANCMNNNNNTCTNGNA NGNNGNNANGNGNTNNNNNATNTTATTNTN^ NNGNCATNNGOWINGGNNANNNGCCGN^

TANMSfGNTAATNNGNNTCNGNNNGCGGANNNTGCANGGCNGGANCTNANNNGGNTNATT ANACCANNNTGNNNTGGTATCGTNNNNNNTGNCTANTNANNGCGNNAGGGGNAGTNGCG CNNCGNATANATGAATNNGTNGGANNCAGGAGNGTANTACTANTGCNTTTANCANGNAN NTAG(^GAGTOSr(^TANNTGGTGNGNTGNTGTATTATTANCAGTTNNTNTTGTGAACTCN NCAAGANANCNTATGCAGAGNAATNTANCGTTNTANNCGTGNTNNAATNCNCNNGNGCA

NA(^CNCGNGTNCTCrø[CNAGCGCTNNNTACTGNNNACATGNANTCACCGCNCATANTGN ATCATCTNNNTGATANCTAGANACACTTGTNTGNTANNTNACCG

GNCTATCTGGAGCTNCACCNCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAAATTCGGCACGAGGCTCTGTCCAAAGGGTTCAGGAAGAGAACATGATGGTGAGC CACAGCCCTCTCAGGATTCGCTGGCATCTCATCTGAGGGTGGGAGGGCATACTGGGTCTTC CGTCTCCTCCAAGCTTTCTTTGTCTGTCTCAATCTCTTGGCCTGGCCCCTCTCTAAGAGGGG ATGGCAGTTATCTGGGCTTCTCTCTGGGATGGCCGCCATCTTTAGTAATTGAGAAGGTATT AGATAAATCAGCTACCCCGCCTAGAGATATTTCCTCTAAGTTTTCAAAAGAGAGCTGGGCT

GTAGTTATCCCAAACGTGCATTTCTTCAAAGTCCAGTCATCCTCTGGCCTTTTCCTTTGTGA CTCCATACAAAGAGTCATGTTCTGCCCCAAAGGCGTCCATTCCAAGCCTGGACTTGGGCTC CCCCGTGAGAAATCTTCCCAACAGCTTCTTGGCCCAAGCTTCCCAGACCTCCTCCCCTGGA ACCTCCAGCCCGAGTCCCCGTGTACACGTGGGCTGTCCCAGGCAGCCAGCATCCCTTGTAA GTTCCCTCTTTGGAAATGGTGTGTGGGTGTTCAAGTTCTGTGTCTGGTGACTATGAACAGA

CAGTGACTCTTCCTGTGACCTGTGGGAAGCTGTGAAANCAACTTCTGGAACGCCGANGAG CTTGTTTGCTTTGAACCGGGGAANAAAAACTGNGTTTTGAGGTTTANCTGAAAATTAAGG GGGAAAAAAAAAAAGTTNATTAANGTGACTNGTAATNGAAANCTGGTNTTAAAAANAAC TNTGAAACCCCCAAAAAAAAAAAAAAAAAAANTNGGGGGGGGGGGCCCGGGNNCCCATT TNCCNTTAANNGGGGGNGNNNNNNTAANNNNN^

NNMWTNNNNNNNNNNNNC

GCCCTATNTGGAGNTGCATCNCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGTTTGGACTCTGAGACTGACAAAAGGGGTACCATGCTGTCTGGCACTGCNGCACNC

NTTTGCTGAAGAAAAGTACCCACCTTGANTGGTAATCCCCANNTTCACTGANCCTTGTTGC CCTGNACCTCACTCTAGGNATGAAACCNNGATGCCNGGCTNGTNCATAAACCCTATTCTT ANTATTCCNAAGGAGCCANTNNTTNTNTACTGAAAGCATNNCCNATACTACCTGANCACT ANTCTAAGAGNANANNCTNNATACCATAT^ AATATTNATAGGCNATTTTANGAAGCNAC GGAANGANNACAAGTA WTCATTNCTGATNCTNNNTGTANCAACNNTGTTTACATNCTAC

TGCCCACANTNTGNNTCTCNTNCNTTGNAGGGACTNNTCCTNANNTNAGNNNANNGTGAN TCNNGNTNTTITTANNGTTTAANTGCAAAAGGCCTGAATNNNNNKNACTGACTT^ NCTCTAGCCNAANCCCTNCNNNNTNCGNANNGANGNCCCACATAGNCAGNTNNCTTTTGA CTCGTCCNNANCGCCTTCCTNCTTTCNCGACANNANNNATACCCTGNGGCCATNCCCTNG ANNGGCGNTTATGANNGCTTTNGANTCTCTNGTTCCTCCAACTCNTTCTNGGGAGNAGCC

NTGGNNATTNNTNNTSfANTTNNGGTACTGCAAAGNGNTGNNCTNTAGGCCTTCTN^

NTCTCCCTTNNGTNCCACCNTNNCTNTNGNNANGNCTANCANNGNNCTNANTCCNGGTTT

TAA(^TCTCNNTTmCAAAAANGCACANNNNNNCTTTGGNNANNTTG(^CTO

AATGTONINAATTTTNGTTTTTATATACA^

NNCATTNCTTCCATCTNCTTTNTTCGCTNNNTNTGNCTNN^ATTGCT^

TNNTGNNTNNANTGTTAANNNACC

NCAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCTCTGTCCAAAGGGTTCAGGAAGAGAACATGATGGTGAGCC ACAGCCCTCTCAGGATTCGCTGGCATCTCATCTGAGGGTGGGAGGGCATACTGGGTCTTCC GTCTCCTCCAANCTTTCTTTGNCTGNCTNAATCTCTNGGCCTGGCCCNTNTNTAAAAGGGN ATGGCAGTANTNNGGCNTTNTTTTNGGAANGGCCGCCNTNTTNANNANTGGAAAAGGNNT AAAATAANNAACNTCCCCNGCNTAAAAATTTTCTTTTAANTTTTAAAANAAAGAGNNGGG

NGTGTANTTATCCCAAACGCCATTTNTTCAAAGTNCAGCANATCCTGTGGCCTTTNTCTTT GANACT(^ANACAANAGAGNNGTGTTGTGCCNNANGNGCGCANATTNNANCCCNNGCNC l^GCTCNCCCNCGAGANANATTTNCNANACATTTTTTTGGCCCAAGNTTCNCAAANCTTCT CCTGTGAAACCTNCANCCAGACCCNCGTGNACACGNGGGTNTGNCNCANGCACACCANAT CCCNTGAAAGN(^CTTTTGAGAAAAGGGNGNGGGGGTGACAANTGTGGGTGGTGGCGAT

AACAACANNCGCNCTCCCCTGCACCTGNAGAGCTGAAAAACNCTGTACACCCCAAAAGCT TTTTNTTTCACCGANAAAAAANCTGGNTTTNGANTNAGCTNAAATGGGGGGNAAAAAAAN GTTCNTNNGNNGCTGTNANGNCCCOSINTTATAAAANNCCNNGNCCCCCNAAAAAAAAAA AAANNCCNGGGGGGGGGGGCCCCCNNNNNNNNNTTTTTNNNNNNNNNNN^

NCAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCTCTGTCCAAAGGGTTCAGGAAGAGAACATGATGGTGAGCC

ACAGCCCTCTCAGGATTCGCTGGCATCTCATCTGAGGGTGGGAGGGCATACTGGGTCTTCC GTCTCCTCCAANCTTTCTTTGNCTGNCTNAATCTCTNGGCCTGGCCCNTNTNTAAAAGGGN

ATGGCAGTANTNNGGCNTTNTTTTNGGAANGGCCGC(^TNTTNANNANTGGAAAAGGNNT AAAATAANNAACNTCCCCNGCNTAAAAATTTTCTTTTAANTTTTAAAANAAAGAGNNGGG NGTGTANTTATCCCAAACGCCATTTNTTCAAAGTNCAGCANATCCTGTGGCCTTTNTCTTT GANACTCNANACAANAGAGNNGTGTTGTGCC1S1NANGNGCGCANATTNNANCCCNNGCNC TNGCTCNCCCNCGAGANANATTTNαSfANACATTTTTTTGGCCCAAGNTTαSfCAAANCTTCT

CCTGTGAAACCTNCANCCAGACCCNCGTGNACACGNGGGTNTGNCNCANGCACACCANAT CCCNTGAAAGNCNCTTTTGAGAAAAGGGNGNGGGGGTGACAANTGTGGGTGGTGGCGAT AACAACANNCGCNCTCCCCTGCACCTGNAGAGCTGAAAAACNCTGTACACCCCAAAAGCT TTTTNTTTCACCGANAAAAAANCTGGNTTTNGANTNAGCTNAAATGGGGGGNAAAAAAAN GTTCNTNNGNNGCTGTNANGNCCCCNNTTATAAAANNCCNNGNCCCCCNAAAAAAAAAA

AAANNCCNGGGGGGGGGGGCCCCCNΪNΪNNNNNNNTTTTT^

TTGANACCNTCTGGAGCTCCCCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGNACGAGGNNNNTTNNATGTNTGNACCTGGNCGNTGGGCCCNGGGG

(^TANNCCCCNTACTNGGAGTNNTAC^ATNTTCTTAATTTGGAACTTCAANAGTCCCTACA AGGGTNNAAAGCCCCTAACCNNATCTGGNCCAGGGTGGCCNTCNCNNCNANCTGGACCNT CACTTNTGACTTNCATGAAGGCNATCCCGGCTTTTTCTTTGGGTCCCCTTGTNGGGTTANC CNTCCACTTACCACAAAAANAAAGACTTTGNGGGGAAGGGCCTGNACCCCAATCNNCCTT NANTTI TCCCTCTNAAAANNTNGTTGGAAACCACAATTTCCATTCTNGCNAGCCCCTNGN

GAAGGAAAANNAGCAAGGNCTTNAACNAAAAAANGGTNCCTTTTGNAAAGNNACNNNNA GAAGGTTTGTTTTTGAN<^TTNNRWTAAACCATTNCCTTTGGTTAT^ ACTGGGNTNATTTTAAANNNCNTTTTTA^

TTCC^TTTCCCATGAAACCNTTTTANTTNTTGCTNAAATNCTTTAANNCCATGN^ CNTNTAAANANTGGNNNNCCCCTNGGTGTTTTTANGAANAAAANNAANGNANACCCCAA

ACCCCCCCTTNGCCANCCCATTTTTTTTTTTNAANNAAANTTNTANCCAATGGG GGGNTAAAANNANTTNTNNNCTNNGCCCCGCCCANTTΓAAAAATNGGAAAANTGGGGGG NAACTTAAAACCACCCNNCCCCCTNGGGAAAACCCTTTTTAAACNTTTTTCCCCCGNNGGN ATTCCCTNAGNGCNNTTTCNNGGGNΣWTNTAAAGGGGNTAAAANCAAAAAANTTTNCC^ NTGGTCCGTTTCANAATTCCNNTNCCCNTNGGTNTATCAACCTNGGCOSICTNGGNCGCTTT

TGNTNTACATM^NNNCCCATTTCCTTTTTTNCCTCTTTAGNCCCCN^

TTTGANNACT

TTNAACACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGG CTGCAGGAATTCGGCACGAGGCTCAGAACTAAACTGTTAGGGTGGGTTTTTGCGTGGAGG ACAGGGGTAGTCTTTTGATATTCATTTTTTGATTT^ AGATGAACTTTATTTACAATACTTTGATTTGGCAGGTTTTCTTCTACTTTTGGCTGCCTGNA ACTGTTNCCATATGATGTAAAAAGCANGTGTAGTGTCCCATTATTATGTGGTTCGGGGGAT

TTTCATTTGT1TTTAAAAANTAACCCATGTCAGCTGGGATTAGACTNCCTANAATCTATCA GTGGNAAANTTACATTGAAAAAATGCCTTTGGAAAATNAAATTTCANACAAAAAGTGCTT AAGAACTGGTATTTTTTCTAAGTGCTTCTATTTATACCAAAAAGCNTTAAAGTAACCCANT GCCCAGTACCATTCTTGAAAAATTCTTΓΓATTTAACCGACCNGTGCTTATTTNATTAAAAC CAGNTGATTCCTNTTAATTATTACNGGGCCGTAAGNTATAATTATTGGGGTNAAAATACCT

TGNAATATNGGACTTTCTGGCCAGTNGGGGAATTTTCACTNAATTTCTTTTGGTGGNGGGA TGGTTNGAATTAAAANCTGGAAGGNGGGGGAAAATTTGACTNNTTTAAAAGNGTGGNCCC CCCCAAAAATCAANAATTAAAATTGGGCCTGGGCCTGGNAAAACCTAATCCTTACCTNCN NAAATCTTAACCCCTTNTTAGGCTTGGAAANAAAAAGTTGGGGANTTTTGGAAAANGGTT GGCANACCΓΓTCCTTGGCCNAAAAAACCNTTNTTTTTGGAAACCNTGGGCGGGANTTGGN

TTGGGANTITGNAAAAAAAAAATTTCAAATTGGTCCCCCCAAACTTN

TNNNNAAAAGCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNNTTNCAGGACNGCTNNAGGGAGAGGAAGCNGGGTGTCTCCNANNAGTNCN

NGGNTGCANAGGGGAGAGAGCTGACCCTTNTCAAACCCCTGCTTTGGGCCCAGCCCTGCG CCAGGTGCTTCACAGCTCTTATNTGCCAGATTTTCCCACCTTGNGGCNCATGGNGCCCCTA ACCAACATNNCAAGAGGCCGATCACCTTGCCACATNTGTGCANGACCTGGGACCACAGGC GTGGACAGGAAGGGCTCTTAAGCCNTCTTTTTACANATGAAAATGCCAGGGCCCAGGGAG GATNAGCAGTCTTTGGAGGTTACCCANCCGGAATACTGGGAGACCTGAACCCAGCATTCT

GACTCTGCATTNAGTGCTCGCTCCATGATGCAGNGGGTCCTAGCCCCCCNCTGAAATGGGT CCCCTCTTCACTGNGTTTCCCAGNATNCTTGCTCTGACCAAACCGGNGAAGGGACACACN CCCACCCWCAAAAGATGGAATCATTCTCTTAACCGTCTTTGTCCCAACTGCCTGCCNNTCC AAACCCGTNCCCCTGNNCCCTGACCNTGCTGGNTGGGGAAAGAGGCTCACGTGGGCCCAG GCTGAGCANNNAATGACCATGTCAAGCTGTCAGACTCTGNGAAANTANTGCATGCTACNG

GCAACCCGGCNTCCCTGATGNCCGOSITGATTTTGGACNTAANGNGGACATGAAAATGCCA CAATTGGGGGNATGGGAGGGCCNCCCCCCCCCCNTGGGTGTATGNCNATGGNCANGGGGT TTNGGTAACCTTTTTGGTTTTNGGGAATTTGAAAN^ TTTTGNAAAAAAAAAAAAAAAAAAAAATTTANNGGGGGGGGGCCGGNCCCCGAT

TTTGGAAACCAGTTGGAGCTCCCCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGCAGGATCNAGNGAGNCCAGGTTGCANNTTTTNNNNAANGANGATNNANNN

NGGNATGGNTTCAAAAGANAACTGGCANTACNATCTGGTACAACTCCANGAGAAGACAT TGGAGAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGNNCNTA

ACGNGTATNNNATNTTNNAAGACAACCATATCACAATGAAACCNTGACTANTGTAANGCT

NGNTCCATGANGNTNTNTNNTCACTATCAGNCTGAGACCNAGGAATANATATAAAACGNT

GCAAAAAAAAAAAAAAAANATNGGGGGGGGGCCCGNNTCNNANTCGAACNTNGGGGGT

GATGGNNTAAAGGAAAACNNTTT(^TANATNGTTGNTCπ^ ANNATATTNCTGOSfNNNTTTACTTTCNGAATTNGAANCTNANTTTπ

CAANCACNTNTSπWTTTT(^TTTAAGTGGNTNTTGTTTT^

TTTTGGNTGGNNTTTTTTCT>IN<^^

TTTNTNNNTNNNGTTGGATCTTTNNCCTTNTNNN^

CCTANTTANTNCCTTTNNNTACNNGGNTTTC^ TTTATTNANTNTNTTANTTTCN^

TNCNNNNTGCNTTTTNNCTTTCNNTTATOSINT^

TTCTNANNTCTNGTACTTCTTTNT^

ACNACNTAGANTCTCTNNTCTCCNCTNNC GCCTATNTGGAGCNGCATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAAGTCGTGGTGATGGAGGGCCCCCTGGGGCTACTGGTTTCCC TGGTGCTGNTGGACGGACTGGTCCCCCTGGACCCTCTGGTATCTCTGGCCCCCCTGGCCCC CCTGGTCCTGCTGGTAAAGAAGGGCTTCGTGGGCCTCGTGGTGACCAAGGTCCAGTTGGT

CGAAGTGGAGAGACAGGTGCCTCTGGCCCTCCTGGCTTTGTTGGTGAGAAGGGTCCCTCT GGAGAGCCTGGTACTGCTGGGCCTCCTGGAACCCCAGGTCCACAAGGCCTTCTTGGTGCTC CTGGTTTTCTGGGTCTCCCAGGCTCTAGAGGTGAGCGTGGTCTACCAGGTGTCGCTGGATC TGTGGGTGAACCTGGCCCCCTCGGCATCGCAGGCCCACCTGGGGCCCGTGGTCCCCCTGGT AATGTCGGTAATCCTGGCGTCAATGGTGCTCCTGGTGAAGCCGGTCGTGACGGCAACCCT

GGGAATGACGGTCCCCCAGGCCGCGATGGTCAACCCGGACACAAGGGGGAGCGTTGGTT ACCCCGGTAACGCAGGTCCTGTTGGTGCTTGCCGGTGCTCCTGGCCCTTCAAGCCCTGTNG GTCCCGTTGGTAAAACACCGGAAACCGTGGTTGAACCCGGGTCCTGCCNGNGCTTGTTGG TCCCTGCTTGGTGCCNTTGGCCCAAAAGTCCCAGTGGCCCCCAAGGTATTCCGAGGNGAA AANGGAAAACCTTGGTGATAAAGGTCCCANAGGTCTTTNCTGGCTTAAAAGGACACAATT

GGGTTNGAAAGGNCTCCCGGNCTTTGCTGGCCATNAATNGNNANCAANGNGGCTCCCCGG NCTGGNNNGTCCCCTTGNTCCCAANGGNCCCTTTTGGTTCCTTTTGGCCCCTTNGCAAAAG AAGGTTNTATTTNNNCAANCTNGNGNNNTNAGCNCN

NCAAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGAGAGGTGCAACTTTCTTCGGTCGTCCCGAATCCGGGTTCATCC GACACCAGCCGCCTCCACCATGCCGCCTAAGTTCGACCCCAACGAGATAAAATGTACCTG AGGTGCACCGGTGGGGAAGTCGGTGCCACGTCTGCCCTGGCCCCCAAGATCGGCCCTCTG GGTCTGTCTCCAAAAAAGGTCGGTGATGACATCGCCAAGGCAACTGGTGATTGGAAGGGT

CTGAGGATTACAGTGAAACTGACCATTCAGAACAGACAAGCCCAGATTGAGGTGGTACCT TCTGCTTCTGCCCTGATCATCAAAGCCCTCAAGGAACCACCAAGGGACAGAAAGAAGCAG AAAAACATTAAGCACAGTGGAAACATTACTTTTGATGAGATCGTCAACATTGCCCGGCAG ATGCGGCATCGGTCTCTAGCTAGAGAACTTTCTGGAACCATTAAAGAGATCCTGGGGACC GCCCAGTCTGTGGGCTGCAATGTTGATGGCCCGCACCCTCATGACATCATTGATGATATCA

ACAGTGGCGCAAGTGGAGTGCCCCCGCTAGTTAAAAACTGCAAANGAAAATAAAGGACC ATTTTGACAACCAAAAAAAAAAAAAAAAAACTTGGGGGGGGGGGCCCGGNCCCCAATTN CCCCCTTTANGGGGGGGNNNNNNNNAAAANNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNTSfNNNNNNNNNNNNNNN^

NTSINNNTSINNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNC

NCCNNATCTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGAGAGGTGCAACTTTCTTCGGTCGTCCCGAATCCGGGTTCAT CCGACACCAGCCGCCTTCCACCATGCCGTCTAAGTTCGACCCCAACGAGANNAAAATGGA CCCTGNAGGGNCCCGGNGGGGAAAGTCGGGCCCNGGTCTGGCCTTGNCCCCNAAAATCG GCCTTTNGGNNTTGNTTCNAAAAAAGGCCGGGGANNACTNCGCCAAGGNAANTNGGGNN

TGGAAAGGGNCTGAGANTACNGNGAAACTGNCCATTCAAAACAGACCAACCCANATTGN GGNGGNACCNTNTNGNTTTGGCCNTNANCNTCAANGCCNTAAGGGACCANCCANGGANC NNAANAANCCNNAAAA<^TTTANNCCNANGGAAACCNTTCTTTTNNTGNAAATN^ TTTGCC^GGNGAANGCGGATTCGGTTTTATACTATAAAAAANTTTNTGGANAACCTTNAA AGAGAATACCTGTGGGACACCCGCCCNCATTTNTGNGGCGTGTGNANNTGTTNTNGGGCG

CGCCCNCCTCTTNGANA<-^CNNTTTGNNTGNTATTTNNCACCAGTGNGCCCCCTGGCGAG NGNTCCCCCCTTCTNTTTTNAAAAACATGNCGNCAGGNNGGAAATAAAAGNGNGNCCNTN TTTCNACCCCCC(^AAAAAAAAAAAAAAATNTTTS[NCTNGGGGGGGGGGGCCCGGGNTTC CCCAANTNTTCCCCTTTTTTNGGGNGGGTTNNTO^ NATNTTTTNCTNNANNNAANTCTC^

^• NTTNATNTTNCNTCTTTTTTTTNNNCTTACTCCCCT^^ TCTTNCTNTTTCOSINNNATNCAATATTNTTTANTNNTNπ^ ATNTANTTATNTTGGTCC TTNAGCCTATANNGAGNNGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAAATTCGGCACGAGGNGATGACTTACCNNNTGGGAGAACANNGGNAGAGGG AATATCTTGN(_^CCNTTGGNTCCTNCACNTNCTTTGNAGGCCACCGGNNNTGGTACCTNTG ACANCNGCNGNNTNCC^GGGNNTAANCCNGGTACCAAAGGTTC^ATNGCCCNTCTTNNA

NCANNTGTTCCCANANATCCCNTCTNATATCNACACANTANNGCCATCTGCCCAATTGAA GGCTNTATGCCTTNGAATNCCA(^CTGACAAAAAATATTCCCNANAGTAATATTTANCAC NCNTAGANACGNGTGTGTNTCTNTGNCANTGNCTATANAANNTNGAGTNGTGTNCACACA CCCCNTGNTAGCGTGNNTNNTTTTTATAACCNNTTCTCTGNNGAGGNNTTTCTNCCTTTCT C^ACTCCACANCTTCTNCAATATCNOWTGAGAGTGTN GACNNTTTTCTCCACNGGANC

ACCCTTGGATCTTTTATTCNTAAAAATNTCANOS1CCCCNCATCANTTTTTCNANGAAGAAN ATGNNTTCCCCTTCGTTGANGNTTNCCTTGNNTGNCNCCTCGTTNGTGGGAANGNTTNTCC CCCCTANNCAGTAANCCANTNTTTTNNCNNAACANTNTTATCCCCCATTNTTTT^ NGNGAAATTNNTTNNNACNAACTTCTTTGTTGCCT^ CATTNGTTTGGAAACAACCAGNCNCTTTCTTTTCTNCNGGGGNNTCNGNAAAAAACCACA

ANANANGTTA(^TTATTTTNNACCCCNAAAGGTNCCCNACCCTGGGCTNTNCGCAAAAAA AATNTTTTTTCTTN(^TAGCCNGNTTAATTNATTCANNTCCCCNCCCCNAGTTTπ NANNGANANAAANNNTTTNTGNNNTATGANNANNACNTTTTTTACC

TTNAGCCTATANNGAGNNGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAAATTCGGCACGAGGNGATGACTTACCNNNTGGGAGAACANNGGNAGAGGG AATATCTTGNCNCCNTTGGNTCCTNCACNTNCTTTGNAGGCCACCGGNNNTGGTACCTNTG ACANCNGCNGNNTNCCNGGGNNTAANCCNGGTACCAAAGGTTCNATNGCCCNTCTTNNA NCANNTGTTCCCANANATCCCNTCTNATATCNACACANTANNGCCATCTGCCCAATTGAA

GGCTNTATGCCTTNGAATNCCACNCTGACAAAAAATATTCCCNANAGTAATATTTANCAC NCNTAGANACGNGTGTGTNTCTNTGNCANTGNCTATANAANNTNGAGTNGTGTNCACACA CCCCNTGNTAGCGTGNNTNNTTTTTATAACCNNTTCTCTGNNGAGGNNTTTCTNCCTTTCT CNACTCCACANCTTCTNCAATATCNOSfNTGAGAGTGTNNGAOSlNTTTTCTCCACNGGANC ACCCTTGGATCTTTTATTCNTAAAAATNTCANCNCCCCNCATCANTTTTTCNANGAAGAAN

ATGNNTTCCCCTTCGTTGANGNTTNCCTTGNNTGNC^CCTCGTTNGTGGGAANGNTTNTCC CCCCTANNCAGTAANCCANTNTTTTNNCNNAACANTNTTATCCCCCATTNTTTTNTTAGGG NGNGAAATTNNTTNNNACNAACTTCTTTGTTGCCTCCAATAAANNNCTGNCNNGCNCCNT CATTNGT1 GGAAACAACCAGN(^CTTTCTTTTCTNCNGGGGNNTCNGNAAAAAACCACA ANANANGTTACNTTATTTTNNACCCCNAAAGGTNCCCNACCCTGGGCTNTNCGCAAAAAA

AATNTTTTTTCTTNCNTAGCCNGOT NANNGANANAAANNNTTTNTGNNNTATGANNANNACNTTTTTTACC

TTGANAACCGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGCTCTNTNCANGTNTGTANCTGNTNGCTCTGAGCNNTTG CCTGNNTTGTAGCANACTATGAAANCATACTNNGNCTCTCTANTATCCTAGNGNGAGTNT TACTCCTCCNGGNTTTTCAAAGGGAGTCTTAAAGCAAATNATAGATTTAAGTGAGAATTC AAGCAAATGT(^GATTAGACTAATCTTGCATTNANATTTTAGATCTANGATATATATACAC GCATGTGAACGTACACACACCTGCATGTACATATGTTTACAGGGCCTTAGCTATCTCAGTT

NATTTTTACTTTGGACTTTNACCCATTTCCCCATTTTACAGAATAAGTGAATTTGTATA^ TGGTAA( NGCTCNCCATTTTTTTTTTT^

ANTTTGGTAAAAAAAGNCTTTNCCCCCNGGCCAANATGGCCCTTANACTTTNGAATNTTTT TTTGGNAAAAAATTTTTTTTAATAN(^TTATTTTTAANAN^ GGAAACTTGNGTTCCAAACCCCTGGGGGAGNAAATTAAAGAAAATNC πSfTTAACCTTGT

TANNNAAAAAGAAGGGGGTTTmCCCC<-ΗAACCCCTGTTGGTNTTCCCGGGNAAAAAAAA ANAAAANTGGGAANCCGGGGTTTTCCCCCCCGGGGCCCCGCCNCCTTAAAAANNNGGNA CGGGGGATTTTCCCCTTITAAAAC(^GGGGTTTTTNAANCCCTGGGGNCCCCCTGGGNTTT TTTGGGGCCAAAAAAAITNCCCCGGGGGNAAAAAGGCAAANTTTTT^^ AACCCTTNAACCCCCCCGGGGGGGGAAACCCCCNTTTCTTAAACCNTTTTTTGGGAGGGG

ACCCCAAA ANCANANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTGC AGGAATTCGGCACGAGGGANANNATAATGTGNTTCCTTATTTTTTAGATANGNNCTTAAG ATAGGTTCATACTATCCTTTGAAAAGAATTGACAACCTGCAAGAATGTNGTTCATACATAT CATGGNAATTGCACAGTAAGGGAGATTNTCATGTNGGATTTGGGGAACTANTTGCATTAN TTCATAGCCATACTTGATGAATNAAGNCACANTGGCTGACNTTGATNCTGAATNAATGGA

CCTAAATANNTTΓGTATTAATGNACTCTTATCTAAAACTAATTTACCATATTTGTTCTGTTT TTGAAAGTACAGGANTTGCCCTTTAATACTTGGTTCAAATTTGAGTACCTAAACCTTCACA

CGAGTATAGATTAAATGGCCAGATACATTACTTTTAGAAAGTCGTTATTATTGATTTATTT

TAACCCCAATTGAGACAAATAAAATATTGGTTATTGAAAAATGNCTTTTCTTTCCATTACT GGCATCTCACATTAGCCCATCTGAGGGGAAAGACAAAACCCAGCTCATTTCACTGGTGGG

AGTATTTCTCATTTTACATAAACTCCCATTATACTCTNCATCTCTTACGAACTTACAGAGNT

AAAAGAGACATTTAGTCTAACAAAGAACCTGGTTTTTTTCTGGCTCACAGATGGTTNCCTA

TGGNGGGATACCCGCCNTTTTATTTGACCTTTAGCCTT^

TTTGNGAAATTCTAACCCTTTCTAAGCATGGT^^ ATTTTTTTAAGCCTTAACCTAAAAAAATTTTTTTTNNT^

AANCTTTAAAAAAAANACCTTTAAAAANGGTTTTTTC

TTGNNCACCGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGGAAGAACTCTGATGCAGAGGTTGCACCTTTTCCCAGATGAAGATATACCAGAA

GATATTCTTAAGAATTTAACAGAAGAGCTTCCTCAACCACGAAAAGTGCCCAGACGTCTA GATGAGTACACACAAGAAGAAATAGAGGCTTTCCCAAGAGTTTGGTCTCCACCTGAGGAT TATCGGCTGTAGGAGGAAGAAAATTTCAGAAAATAACGGTGTGGTGCTTGAAACTCCTTC CTCAGGGCAGGATGAAGCAATAGCTGCCTTCTGGAAGGAAGCCTGCTCTGGGGGCTGAAA GTTTGTGGGGAAAGGTCGGGAAGGGGTATCCCTTCATTAGGAAATTGCAGTAAGATGTCA

TTTTATAGAATTGTTTTATTGTATAGTGCTATTTGAATGTTGGAAATGATAAGAATAAAAC TGCGCCTTACTTCAAAAAAAAAAAAAAAAAAAAACNNTGGGGGGGGGCCCGGCCCCAAT TCCCCCTTATGGGNGGTGNCTTACACNCNNNNNNNNNCNANNACTGGGNNTGNNNNNNN NNISINNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNTNN^

NNNNCOSπSINNTNNNNNNANNNTNNNNNNNN^ NNCCNNNNNNNNNNISINNN^ NNNNTNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNN^

GCCTATNNGGAGCCGNANCNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGATAGTTGAGACTTGTAGACATTTATTTATACTGTGTCATGTTT TATAATTTATACATAAAATGTCTGGTTGACTGTACACCTTGTTTTTGAAGAAATTTATTCGT GAAAGGAAGAGCAGTTGTTATTTATTGTGAGGTCTCTTGCTTGTAAAGTAAAAGCTTTTTT

TTTTTCCTTGNAANCCNTTNAAGNCCNTTCCTTACTATNCACT(^CTCATCNGNCTCΑSFTTC NTTNACCTGNCGTTANACTNTTTTCCACTTTANCCANCTNGCATGTCAGTTNCTGNCCTGTT AATTNATNGNATNCTCNGCTGC(^GTTCTGNNCATNCCTGANCCCTCGGGTTTNGTTNACA AGGAATCTNGACTGACCAAANGGCNTTATANCTNTGACTCAAATAGCAGGTCCAGAGGAT NCNTTTTTGAGGAANCNCCNATTTCTGTTCTCNGGTNGGNANNAAAACATCGGNGAGGGC

AGGNGGNNATANCAGGGTNGGGTTTCTAATCATGCCTTCTAANAGGTTNCANANCCAAAN AATNGAGNGATANGGGNGNCAGGACCCTGAAANAAGGAAAANGCTGTACATTCAACCTT ATGTTAGGGGTTTCCTTNAAAGGNTAGTTTGCTGTN^ NTGNGCCNTGAAAAGGTATATCAAAGCTTTNTNAGNCCANGGTTCTNGGCTTTTNAAAAA ACTTTTTTNNNGAGGCAATTTTTTATTTNCAAACATGGCA^

AANNTNAAGTTTAANCTTΓTTCTCCCCTGGAAAGGNCCANTNGTTAAAAAAAGTTAATAA GNGGGTTTTCGCAAAATAANGANGAGGGAAAAATTANAAAAATTTTAAAANNCCNNAAA AAAAAAAAAAAAAAAANT

NAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGGGAAGACTTACCACGTGGGAGAACAGTGGCAGAAGGAATATCT TGGTGCCATTTGCTCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGACAACTGC CGCAGACCTGGGGCTGAACCCGGTAACGAAGGCTCCACTGCCCACTCCTACAACCAGTAT TCCCAGAGATACCATCAGAGAACAAACACTAATGTCAACTGCCCAATTGAGTGCTTCATG CCTTTGGATGTACAGGCTGACAGAGAAGATTCCCGAGAGTAATATTTCCAACCCAGAGAA ACAAGCGTGGATCTCTGCCAAGGTCCATCCAAACTGGAGTGGTGTTCGCAGACCCCATGT TAGTGTGTTCCTTTCTTAAGCCCTTTGCTCTGGAGTAACTTCTCCAGCTTCAGCTCAACTCA CAGCTTCTCCAAGCATCACCCTGGGAGTGTTTTCAGACTTTTCTCATACATGGGAGCAGTA

GGTTATCTATTCTTCAAAATATTCCATGCCAATCAGTATTTTAAATGAAGTGATTCTAACTT GNGATTTGGATTGGGATCCATAGGGAAGCACATGCCCCAACCAAGATCCAAAATGTCTTG AAATGATATTACCAAAATTTTAAGTAGGAAAAGNTACCTGAACACTTNTGCTTNCACTTA ACTGACTGGGCCCGCAATANTGNANGAAACAGCATGNCCCTTTGNACTGGGGNATTCAAA AAAAAGCCCCAGTACTTCACTTTTTTCCAAANGAATCTAAGTAATTGGCCTAAAAAAAAT

CNTTTTTCNTAACCCGGGAATTTAATCAA^

AAATTGGNNCTGGGAAAAANACCTTAANNNTGCCNGTTNNANAAAAAAGGNAAACNGGG NCTAAAATAANGGGGGGGGGGAATAATTTTTTTAAACCCGG

NCNANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGAGAAGGTCTTCCTTGCCCAGAAGATGATGATTGGTCGGTGCAACCGAGCTGGGA AGCCCGTCATCTGTGCCACACAGATGCTGGAGAGCATGATCAAGAAGCCTCGCCCTACCC GGGCGGAGGGCAGTGACGTGGCCAATGCCGTCTTGGATGGAGCCGACTGCATCATGCTGT CCGGAGAGACGGNCAAAGGGGACTACCCCCTGGAAGCTGTCCGCATGCAGCACCTGATTG

CCCGNGAGGCANANGCTGCCGNCTACCATTTGCAATTGNTCGAGGAGCTNCGTCGCCTGN CACCCATTACCANCGACCCCACCGAANCTGCCGCTGTGGGGGCCGTGGAGGCGTCCTTNA AGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGGTCTGCACATCAGGTGG CCAGATACCGCCCCCGGGCCCCCATCATTGCTGTGACTCGGAATCACCAGACAAGCTCGC CAGGCCCACCTATACCGCGGCAATCTTCCCTGTGGTGTGTTAAGGGACCCANTGCANGAG

GCCTGGGCTGAGGACGTGGGATCTTNCGNGGTGANCCNTNNCCATNAATGTTGNGAAAAG GGCCCAGGGCTTTTTTNAANAAAAGGAGAAAATNGGTCANTTTTTGCTNAACCGGGTGGG CGCCCCTGGTTTTCGGCTTTTAACCAANACCCAATGCGGTGTAGTTTCCTTGTGCCCATGA NGGGACTTCGAAGCCCCCTTTTTCCANGCCCCCTNGTTNCCACCCCCTTTTTNCCCAAAAA CANTTCCNTTAGGCCCAANNNTTGCTTTNGAATNGCTTCANCTTTGGGGGCTNGAATNGG

GGGCANCCTGGTGGGGGTTGGGANCACCCNANGGAAANAANAANGAAATAACCTTCTTG TGGAAANCCN

TTNNAGCCTATANNGAGNTGTATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAAACTACACTTGGTTACCAGTTTGGGGTCGAGATGTCCTACGTCCCGGGCC AGCCGGTCACCGCCGTGGTGCAAAGAGTTGAAATTCACAAGCTGCGTCAAGGTGANAACT TAATTNTGGGNTTNANCNTTGNAGGCGGANTNGACCAGNATCCNTCCCAAANCCNTTTTT AAAAAAATAAAACANACAAGGNCNTTTACNTANNACGGNNNTCCAAAGGAGGCCNTGCG NAAATNGNTGGGNTGCAAATCGGGGACAAAGATCATGCAGGTNAACGGCTGGNACATGA

CNATGGTCACACATGACCAGGCCNGGAAGCGGCTCACCANGCNCTCNGAGGAGGTGGNG CGTCTNCTGGANACGCGNNNATCTCTGCAAANGGCCGNGCAACAGTCCATGCTGTNCTAN CANCTGCCAGGGGCCCCGGCTGTGCCTGCCCGCCNTTTGTACAGNGACACCANTTNCACG CTNTGTCTGCCTCTCATCCTGGCTTCTGCTCATTGNTGGGCCCCCCNCTCAAAAGGGCAAC ACGGATCCCTGCCCGGTCTGATCCCCTCTNCCCGTACTGCCCAGGTCTTGTGGCACCATNT

CTCCCTCTNGGATGCTGAAGACTGGCAACAGGGCCTGGACCCGANTCACAATCANNCTGN AGTGACAATTTTGGGCCNCAAAANCTTGGTTGCTTGGCCAAAATTATTCCCCAGGTNATNA GGGGCCCTTTTTTCTTGATAC( NCCCCCCNTNTTAAAAAACCCC^GGGGNTTGGCCCCTTG CCCTTTTTTTTAAANTTCCGNAGTNN^ AGGGGGACTTNTNTTCTTGGCAAAAAAAACT

TTNANCAACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGAAATGCTGAGGTGTAGACTGACAGCTTTAACACTGCT GAATGCCAGGTTACACAGTATTCTTACAAAAAGGGAAGTCAGCCAAAGACTGATCTGATG

GACCAAAATTGGAATTTTGAAAAGCACCAGTACTACTTTCCAAAATGATCAGCAGGTTAA ACATGTTCAGCAAGGTATAGTGTGAATCCATTAACCCTTCGTCGTCCAGGGTCCAGACCAG AACTACTTGTTAGTTTTGAAAATGGTAGCCCAGAATGTGGTTGTGTGCTTTATGGAAAGTC AGCAGTGGCTGCAGGCTTGGGTAAACAACCAAAGTTTTCANGGTTGGNAAAACACTTCTT CCTTGTNCATATCCCCACCAGGCTTTAATTNAAAAATCTAAAGGNGGNCCGTNACCTNGG GTTNGGTTTGGTTTTNAATAAAGNCWTTNGAATCNGGTTTACCTNGNTTT^ CTTAAAGNAATCCTAAATCTTTTTAACCTNAC(^TANTTGCANTTNCCCCTGNANTTTCAT GGACCAAGTTGGCTTTNANTTTGGTCAAGGGGGGGGTTTGGTTTTGGT^^ TTTTAANTNAAAAACTTTTGGTGGGCCAGGGAATCCCCTTTTTTCCCCTT^

CCTTTTGGCCANCCCCCCTGGTTTAANGGGCCCTGGAAANCCCCTTACCCCGGCTTTGGAA GGGGTTATTTTTTTTAAANGGGGGCNCCCCAAAATN^ AANNNGGNAAAGGAACCTTGGAAANNN<_OTTTTTTTANAA^ GCCCCCNAANGGGTTNAAAAAANCCCCCAAAAANGGGGGGTNTGTNCTNCCCC

NAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTGCA

GGAATTCGGCACGAGGGTCTTTAAACCCTGCGTGGCAATCCCTGACGCACCGCCGTGATG

CCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCATCCAACTTCTG GATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAAGCAGATGCAG CAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAACACGATGATG CGCAAGGCCATCCGAGGGCATCTGGAAAACAACCCGGCTCTGGAGAAACTGTTGCCTCAC ATCCGGGGGAATGTGGGCTTCGTGTTCACCAAGGAGGACCTCACTGAAATCAGGGACATG CTGCTGGCCAACAAGGTGCCAGTTGCCGCCCGTGCTGGTGCCATANCGCCGTGTGAANTC ATTGTGCCAGCACANAACACTGGTCTGGGGCCCGAAAAANACCTCCTTNTTCCAGGCTTT

AGGCATCACCACNAANATNTCCANGGGGCACAATTGAAATCCTGATGATGTGCAGCTGAT TAAAACAGGAGACAAAGTTGGCGCCAGCGAAGCCCCCTTGNTGAACATGCTGAACATNTT CCCCTTTTTCTTTGGGCTGGCATTCANCAGGGGTTNGACAATGGCAGCANTTTACAAACCT TGAAGTGGTTTGACAATNACAAAAGGAAACTTTTGANTTCCCGNTTTCTGGGAGGGCGTN CCCNAATGTTGNCAACCGTTTGCCTTCCAAATTGGGTAACCCAANCCGTTGGGAATTTTGG

ANCCCC^TTTTTTTATTAAATGGGGTNCCAAGCCCCGGCCCTGGGTTTTTGGCTTGGGGGN NAAATTGANTAA<^CCNTTTCCN<^TTTNTTTAAAAAGGGCCAAGGGCCT

TNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCNCGAGGGANAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA GAGAGANAGAGNGGGNGGNNCNGNCCCNNNCTNCGNTATANAGAGANNCATAANNCCC CCTNGCTACTNTGNTCCATATNTAGANNACTGTANGNCCNNGGCACCCGCACACGCATCN TTTGTAGNATTCTTTCTTCGTAACCGTNNCGAACCATNATNGGACCCATTCAGTTCNCTNA CTCNTCTCCCTAANAATCTTCTGCTGNCGACCTAGCATGNNCCACNANTAGGCCCCTNTNA

GCGTACNNACTTCTCCCTACGTTATTCTTACTACTCCNCGGATANTCTATCGTTGGAACCTT GGGGTTACGNACACGCNTGTACCGNGTNNCCTCTCTNNGNNACCGTGNTGAGCCATGCGN GANCTTTNGTTTATCNNACCTTNTT ^ GCCCTAANCTTCNTTGCGTNAATTATNNACATACCCGCCNNNANCNTTGTGGCNTGACCA AACTNCCTNTGTTTGGNATNATCCGTAATAAATTACCGGACCGGCCTANTACTNNNGCTCC

TTTCCATGCGTTCCCCNNACCGGANNNNCTTTTGNCNNTTNTNTNACCCNGAACCTAAATT GCTTGGCNTTTTTGTTTCCCGGGGGGAAGGAGGAAAANCCCTTNTTCTTTTGNCCTGCACC TTTTTTTNNNNATTCNTTTCGGACAANCCCCGAAAGTNTTT^^ GGGCCTAAGGNAATNAAATTTTTTAATATTCCCTNGGNCTTGNTNAGTAAANGNGAAAAA NTTTGNCCCCTTTTNGNNTATTTTTTGGGNAAAAAATTTGGGCCTTTG

TTTNTTTGNNCNGGGNNCCAAGGGNAANGGGGNCCCCCCCTTTTTTTTNCMNΓT

TTNNNCAANGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAAGTGGATCCCCCG GGCTGCAGGNCNNAGTGCGGTGCGCGCCTGCGCTGGCCCTCGCCTCGGAGCAGCCATGAT

GGAAGGCCTGGACGACGGCCCCGACTTCCTCTCTCAGGAGGACCGCGGACTTAAAGCAAT AAATGTAGATCTTCAGAGTGATGCTGCTCTGCAGGTGGACATTTCTGATGCTCTGAGTGAG AGAGACAAAGTAAAATTCACTGTTCACACAAAGAGTTCATTGCCAAATTTTAAACAGAAT GAGTTTTCTGTTGTTCGACAACATGAGGAATTTATCTGGCTTCACGATTCCTTCATTGAAA ATGAAGACTATGCAGGTTACATTATCCCTCCAGCACCACCAAGACCTGATTTTGATGCCTC

AAGGGAGAAACTACAGAAACTTGGAGAAGGAGAAGGGTCTATGACAAAGGAGGAATTCA CGAAGATGANNCAGGAATTGCAAGCTCAGTACTTTGGCAATATTCAAGANGACGGTTGCA ATGCATGAAGTGTTTCTGTGTTTTAGNGGCTTGCACATCCCATTTTGAGGAAAGATTTAAA TTTCCATGTCTTCCTGGAATATAATCAAGATTTGAGTGNGCGAAGGAAAAAAAAAAAAAA AAAACCTNGGGGGGGGGGCCCGGGCCCCCAATTNNCCCTTTTAGGGGGGGGNNTTNNNN

NNNNNNNNNNNNNNNlSπsπSfNNNNTSi^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNTSΠSINNTSΠN[NNN^

NNNNNNNNNNNNNNNISINNNNNNNNNNNN^

NNGCNGNNCNNC(^TNCTCNNNNNNNNNNNNNNANNNNNN^ CCTNOSINTTNATNANCNTCWCTNαWGGGGNNNNNNGTANNGTCTNTNCNNT^ ANTGGAGCTNCACNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGNT

NCCAGGGAAN(^(^GGTTATTTGNNTGTAAGNTCACCNNTGGGGANCAAGCTNANNTGGT GNNGANGGNCTGGTGCCTGGANCAAGTGNTTNTTNTTCCA(_^TNNTTNCNTATAANC^TT TATNCCNNTCNNGGNCTGACCTCNCCAAGGGCCNGGNTGCATGCTGCTTGAGGATNAGTA GNATGTATGNAAATTNCAATNCTCTGTGACCACCCCTTGGTTCATGAACCATCAAGACAG GCCGAGATTCNTAGACCTAATGCATTGANNTGNGNCGTGTNGATGCATANTGCGACCTCC

AGTGACACTTGNGCCTATTGACGACANTGTGNGCCTGAAANCAGAGTAACTNAAGGCTGG AGCNGGTCAGTGAGAGACATCCAAGTGCCCTNGGTGNANTAACCTTCGGGTAGNTGACNA ANTCCGATCCTNCCACCNTACTANAGGGNCAAGTCCTTTNGNNGATTTTGGAATGAATGC NTGGTGGNANNNCCGGGCNATTGNNGGANTGAGGGANGNCAATGNNTTGANNGGGGTGN AAANNNAAACCCGAANGGGNAACACNAGCCTAGAGGGGGGNNCNNNAATNTTTTNGGGG

GNAAACTTCAATGNNNCCAAAAAATTNAACCCCTGNAAANTTNNNGCTNCAAAAATTCTN TTANCAANTTNAANTTGTATTCNTANNAGGGTCTAGGNCNNGNTTTTNNATNAAAANAAN AANTTCGGGNNTGNGGTAACTTTTTGNTANAAAAANGAATGNTGCGCCCANACCNNNGCT GGGATTNNTTTNNANGAAAAAAATANNNCCGGNGGNTTTCNTNNNTATGGTGCGGCTTNN TTTTGCTATTNNNGANANTACTGNGGNAGNCTACAANGGNAANTTGACTCANCCANAACC

AGGGNCTCCCTTTTTNNTCCANTTNCCCCCCTGTNCAAAGTGCAOSπsrGTANNNACATGNA (-^TTGGGNTNGNGCGCGCATITTCCCTTTTTNGNCNGGANAGGATTCTTTATCCCNCACTC CTANNGNGG1TGCAAAAAACNCCTCNNATTTTTTTGCACATTTGNAGNGGGGGGAAGGAA ANATAGTTNACCCTATTNTTGGAAGNCGNTGCCNAAAGTNNTCACACANNACAANAGAG ATNTTCTCTNTGTGNGGGGGNGTNGT<^CCNNNNCTTACCTATNAATNGGCGCTNNTNNTT

TNNNNNNANGNAGCCCNAACNCTATTANTTACATTCATCGNTGNCTATNTCC

CNCNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGGAATTTCGGCACGAGGCGACCAGTGACTAGACTGAAAGAAACTCATCCTTTGGGAG

TCATGGCAGCTGATGAAGATAACAAAGAACAAGTTCTTAAGGAATGTGAGCAAGCTGAA GAAATTATGAAAGATAAACAAAACCAGAAATTAATTAGTGAAATTACAAAGGAAAATAT TCAGTTAAAGGAGGAGATCAAAAAACTTGAAGCTGAGTTACAGGAGACCACCAGGACCT CCCAGATTAATGAGGATATTCCTGAAACAAAGATAAAGTTCACATCTGTGGAGAATCCTG AGAGTGACAGCGAGTTTTTAGATATCTCCTATTCATGTCAAGTGAGCTCAAAAGTCCCTTA

TGAGCTGCAAAAAGGACAAGCACTTATTACCTTTGAAAAAGAAGAAGTTGCCCAAAATGT GATCAGAATGGAATACCATCATGTGCAGGTACAGAATGAAAATGTGATGCTCACGGCCAA CCCAGTTTCGTTAAATTCAGGAGTCAAATTCCAGGTTCACGTAGGAGTGTCTAAAATGAA AATCAACGTTACCGACATTCCTGATGAACTGCTNNAAAGTCAGATGAGAGACAAGCTANA ATTGAGTTTCTTTTAAGTCTCCCAACGGAGGCGGANAAGTGGAGTACCGTGGAGTTTAAC

AAGCAGACCCNGAGCCGCCCTTTTTCCCTTTTNGGGAAAGGGGAATTTCTTGNNAAGAAT TTTTGAAAATGGAAAGACTNTCCTNTTTTNTTAAAATCAAAACCTGGCCATAAAGGTTCCN GGTTTNTCCCTACNCC^AAAACNNCCCTTTGGAAAANGTTTTAGGGTTT^ TTNTAAAAAGGCCAMSrGTTTTTGGACTNGGACNTTAAACCCCTTTNAAAACCNCCNGGπ NAAAAAAATTTTTAAANGGGTTTTTTTNTNC^^

CAANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCTCCAGCAAAGAAGATAAAGCCTCAGACCCCCAACACATTTCCTAAAAGGAAGAA

GGGAGAACGAAGGGCATCCTCCCCATTCCGAAGGATCAGGGAAGAGGAGATCGAGGTGG ATGCTCGAGTGGCAGACAATTCCTTTGATGCCAAGCGGGGTGCAGCTGGAGACTGGGGGG AGCGAGCCAATCAGGTTCTGAAGTTCACCAAAGGCAAATCCTTCCGGCATGANAAAACCA AGAAGAAGCGGGGCAGCTACCGGGGAGGCTCCATCTNTGTCCAAGTCAACTCTGTTAAGT TTGACAGCGAGTGACCATGGGCCGTCTATGGCACAGCAAGGGTGTGCCCACTCAACGTCC TCAGTGGACCTGGGAATCCTAGGCTCTATCAGGGGAGGGTCTTGGTGAAGAGAGCAGTTT ANAATAGGTCTGAAGACTGCACTGTAACACCCTCTAAGGTCCTTTTTTGTGTTCGTGGTTT TGTACAGATTTGTTTTTTGAGTGTTGGGTAGCAAGGACAAAGAGTGTΓCATTTTTAAGAAC AATTTTAGTTGTCATTCCCCTCCATGTTCTGTGAAAGTCTTCATACTGAGAAATTTGGATAT

TTTCCTATTAAATCATTTCTTATTGAAAAAAAAAAAAAAAAAAACCNTCGGGGGGGGGGC CCCGGGNCCCCAAATTTNNCCCNTITNN^

NNNTNNNNNNNNNNNNNCN^ Nl^>>MNNNNNNNTSlNNNTSπS[NNNNN^ NNNNNNNNNNNNNNNNNNNNOSfNNNOSπ^

TTTGNAGGNCCNCNTAGNGGANGTTCGTCATTACAGTGGGNTGGACGNTTTANAACTAGG GGGCATC^CCNCGGNCTTGGAANGTAAACTTACACCCNGTCTCCTTTNTTTTNNCGTCTAT TATNNTTTNNATNNN(^ANNGGGGGC^TNTNATTNNTNNTr^

AGCTTNACTCTTTTTNNNTCGNGACANNATNTNACNGGNCGGAAAGTANACTTNTATATN CNTGATGANCTCTTAACTTTTATNCNATGAGTNGTTATNNTGTGTTNCTATNTNAAATTCA TTANGCANNNANTCANATTANNTCTNCACTAACGCNTANANCANTNAGTACCNCTGCGGG CTNCTNTTAANACTCGACCACGNGNGNAATNCNGNANAGTGNAGNNTCNTNTTGCTNAGA AAATTTTGCGTGNNGNCTTGNNAAGAATTCTGGGGNGACNAAGAATCANTNTCAAGAGCT

GAAATCGGTTTGCMNGACANTAGACTCANTGTGTTNACTNNNNTTGNANCTA(^GTCC(^ GGNAANNNCGAGATTTNACACATNGGCTGCTTCGGNNAGGTAGGGTTGTNTTGTNGTTNT TGCNTTGGTTNGAACNACAGGGCNNATTANGCNTTGGCNNTNAANTGNCCNTNNNAGACC NTTACCNATTANTTNTTNTNTAAANTANNTATNNTNGAANGTTGNNTCNCCTNGATTCGNT TNACTTTGTGNCTGTATNCCTTCTNTNAC^

GTGATNATGGGNINNNTNCAATTNCTNNA^ NANTANTGTNNATNAT<_OTGGANANTlNπS^^

CGTGATC^TNTCNTNATNNNNCNTCTTNNCNTNTATACNNNATNAGAAGTNNANNATNTA CACNNATCCTTCTTTCCTCCTf^TTTGGGAATNNCNTTGANGGTACTTNGTGAAAAACANT NNGNNTTTTTGGTNAGNNCCCGrW^^

NAGNTNNNNTANGAGGTANTGACAATAANNTAATTTGTNTCACNATTGGGANTNCNANTA TGNNNTTTATNNTTTNTNNTNGGNNTTTNTTNTGNGT^

GAGTTTNTCNNCGTNGAATTCNNTCTGNTGNTANTATNANNNGGGNTTATGGGNCTCCCTT GGNGCNNANTGGGTATANTCNGNAAANNNTTGCCNGNTGNTGGGNATNTGTGTGCCGCCT AAGNGN(-^TTTTNTACGACTNCT(^ATATTTNNTNGCCTACNAAGGGTGTNACNTTGNGN

TATTNNANTTGTGANTCTTATATGNTNANCANNNG

TTTGNAGGNCCNCNTAGNGGANGTTCGTCATTACAGTGGGNTGGACGNTTTANAACTAGG GGGCATCNCCNCGGNCTTGGAANGTAAACTTACACCCNGTCTCCTTTNTTTTNNCGTCTAT

TATNNTTTNNATNNNCNANNGGGGGCNTNi

CNTGATGANCTCTTAACTTTTATN<^^^

TTANGCANNNANTCANATTANNTCTNCACTAACGCNTANANCANTNAGTACCNCTGCGGG CTNCTNTTAANACTCGACCACGNGNGNAATNCNGNANAGTGNAGNNTCNTNTTGCTNAGA

AAATTTTGCGTGNNGNCTTGNNAAGAATTCTGGGGNGACNAAGAATCANTNTCAAGAGCT

GAAATCGGTTTGCNNGACANTAGACTCANTGTGTTNACTNNNNTTGNANCTACNGTCCCN

GGNAAN WCGAGATTTNACACATNGGCTGCTTCGGNNAGGTAGGGTTGTNTTGTNGTTNT

TGCNTTGGTTNGAAC^ACAGGGCNNATTANGCNTTGGCNNTNAANTGNCCNTNNNAGACC NTTACCNATTANTTNTTNTNTAAANTANNTATNNTNGAANGTTGNNTCNCCTNGATTCGNT

TNACTTTGTGNCTGTATNCCTTCTNTNACAAGNNNNCNCTACCNTNNTTTTAAACNTNTπ

GTGATNATGGGN J ΪNTNCAATTNCT WATTTNTTTTT^

NANTANTGTNNATNATCNTGGANANTNNNTANNTNTGGAGTTNANNTNGGTITNNNNG^

CGTGAT<_^TNTCNTNATNNNNOSITCTTNNCNTNTATACNNNATNAGAAGTN^ CACNNATCCTTCTTTCCTCCTCNTTTGGGAAT }N<^TTGANGGTACTTNGTGAAAAACANT

NNGNNTITCTGGTNAGNNCCCGNNGTTNNNAAT

NAGNTNNNNTANGAGGTANTGACAATAANNTAATTTGTNTCACNATTGGGANTNCNANTA

TGNNNTTTATNNTTTNTTWTNGGNNTTTNTTNTGNGT^^

GAGTTTNTO WCGTNGAATTCNNTCTGNTGNTANTATNANNNGGGNTTATGGGNCTCCCTT GGNGCNNANTGGGTATANTCNGNAAANNNTTGCCNGNTGNTGGGNATNTGTGTGCCGCCT

AAGNGNCNTTTTNTACGACTNCT(^ATATTTNNTNGCCTACNAAGGGTGTNACNTTGNGN

TATTNNANTTGTGANTCTTATATGNTNANCANNNG

TTNAAAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGTCCTNGTCGTNGCTGAACTTTCCGGAACCGCAGCTGCA GCCGCAATGGCCCCACCCTGGGTGCCTGCCGTGGGCTTCACGCTGTTGCCCAGTCTGGGGG GCTTCCTGGGNGCCCAGAACACCCGAGGANANGGTTTCCANATGGTACGCCAGCCTGCAG AAGCCCCCGTGGCACCCGCCCCGCTGGATTCTGGCTCCCATCTGGGGCACACTCTACTCGG

CCATGGGGTATGGTTCCTACATGATCNNNAAAGAGCNGNNGGGNTNTTTAANGGAAGCG NTGNTTNCNCTGGGCNTNTACGNTNNNCAANTGTCTCTGAACTGGGCATGGCCTCCCCTNT TCTTCGGCACTCGACAAATGGGCTTGGGCCTTGGTGGATCTCCTGCTGACTGGCGGCATGG AAGCAGCCACGGCCAATGGCCTGGCACCANGTGAGCCCGNCGGNTGCNTGCCTGCTGNAC CNGNACCTGGCCTGGCTGNCCTTTGCGGCCATGCTCAACTACCGAATGGGGNAAGACAAC

CAAGTCCGGAGGAATGGCCGGCGGNTTTTCGGAATGAAGAACCCCTTNCCCTTCCANGAA TTGCAACCCGTTGNGGGTCAAGGCACTTGTTGGGGGGGGGGNCCCCAAGGCTTTCCGAAN NCACCAAGGCCCGCCTTGTTTTGNTNTTAANCCCAGGGGGNGAACCANCAATTTCCAAAA GGGGCTTCCTTNTGAACTTGAACCCCCCAACCCCAAAAAAAAAGGGNNCTTGGGCCCTTT AANCCCTTGNTTNAAAANTTGGTTTTTNAAAAACATTGGAAATTTTNT^

AAAGTGTTTTTAACCTTTAAAAAAAAAAAAAGGNAAAAATTTGGGGGGGGGGGCCCCGG GNNCNCAAATTTTTCCT

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTGCA

GGNANGANNAACNNNGCCCTGCCCAAGAAACAAANGCANAATCGTCCCATTCCTCAATG GATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATTGGAGAA GAACCAAGCTGGGTCTATAAGAAGCATGCTGGGTCTATGAGAAGTGGTCTTAACATGTAG ACCACTTTTTTAAGCAGCCAGATCACANTGAAACATCACTACTGTAATGCTCGGCCCATGA TGTTATTTCCTCCTNTCAGGCTGAGACCCAGCATTAATATAAACGGTNGCAAAAAAAAAA

AAAAAACTNNGGGGGGGGGOSINGGACCCAGTTTNCCCCTNTGGGNNGTTGAANNCANTT GCNAAAGAAGCCTCNATAANNTCCTTNAAGANTACCNGGNGTCCNTCANNGGGGAACTT GGAGAACAAANANCNCAANGGGNNNTAGCNTTTTTGAACNGGGCTTNGCNAACNAATTA ANCN(^TTCTTTGGTAATTTTAAAAACCANTNAATTTTTTT^ TCCCCNTNGGGTTGGGNTGGNNNTGNNTGGACTTANCGGGGAAGGGATTGGTGTAACCCC

CATATTTTGAATTTTTNTTTTAAGGGTTG

AAANNTCNCCANNTTCCTTTTGGANAAAAANCNCCCTTNNCNNNCNTAANCNGGNCCNNG GGTAATGGTTTTTTTTATTCC(^CCNAAAACCCAAGGNTTTTAAACNTTT^ NGGGGNAANTCCCNNGNNCTTTTCTTTN^ NNGNGGGCTTTGGTTTTTTNAAAAAAAACTTNTO

AACCCGGGTTTNAAANCCTTTTTTGGGAAAAAAAAAACNT

TNNNNAACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGGAGAATTCAAGTGTGATCCTCATGAGGCCACATGCTA

TGACGATGGGAAGACTTACCACGTGGGAGAACAGTGGCAGAAGGAATATCTTGGTGCCAT TTGCTCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGACAACTGCCGCAGACC TGGGGCTGAACCCGGTAACGAAGGCTCCACTGCCCACTCCTACAACCAGTATTCCCAGAG ATACCATCAGAGAACAAACACTAATGTCAACTGCCCAATTGAGTGCTTCATGCCTTTGGAT GTACAGGCTGACAGAGAAGATTCCCGAGAGTAATATTTCCAACCCAGAGAAACAAGCGTG

GATCTCTGCCAAGGTCCATCCAAACTGGAGTGGTGTTCGCAGACCCCATGTTAGTGTGTTC CTTTCTTAAGCCCTTTGCTCTGGAGTAACTTCTCCAGCTTCAGCTCAACTCACAGCTTCTCC AAGCATCACCCTGGGAGTGTTTTCAGACTTTTCTCATACATGGGAGCAGTAGGTTATCTAT TCTTCAAAATATTCCATGCCAATCAGTAATTTTAAAATGAAGTGATTCTAACTTGNGATTT GGATTGGGATCCATAGGGAAAGCACATGCNCCAACCAAGATACAAAATGTCTTGGAAATG

ATATTACCCAAAATTTTAAGTAGGAAAGTTACCCTGGAACACNTTNTGNNTTTCACNTTAA CTGGACTGGGCCCCGCAATATTGNANGGAACCAGCATGGCCCTTTTGGACCTGGGGGAAT TCAAAAAACAAGCCCCAGGNACTTCCNTTTTTTTCCAAAAGGAAATCTAAGGAATTGGCC TAAAAAAAAAATTTTTTTTNNTTACCCGGTAATTTAA^

N

TTNAACAANNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGTTTGATCCCTGGGTCGGNAAGGTCCCCTGGAGAAGGAAATGGCAACCCACTCC AGTATTCATGCCTGGAAAATCCCATGGACCGAGGAGCCTGGTGGGCTACAGTCCATGGGA TCACAAAGAGTCGGACATGACTGAGCGACTTCATTTCATTCATTCAAGCCGACCTTTGTTC CCCTTTGAAATCCCTTCAAGCTTTTGGATGTTCTTGGTGGTAACAGCATTAGATTTTGGGAT ATCTTTCTCGGATTCAACCTTGCATTTAATGGTTTTTAGACATTAACAAAACGGATTCTΠ

AAAGGAAAGAAATTAAGTCTACCTAATTCTGCTAGGCACTCGTGCTCCCTGTGTCAACCGT ACTTΓTATAACTATGGTAATGAAGTCAATAGATAGCAAACTAATTATTCCTTCCCCCTTGT AAAATTGAGAAAACTTGCTAACAAGGAACTGAAACTGTTATCTTGAACATAGTCCCCAGT CTAGTTTTTGCCATGACTATAATGAATATAGTCATGTGGNTAATTTCAATTTCCTTGNGGTT AATTTCAAAAGAATTCTCAGATCCCACAGTATAAANGGTGGAAAATTATGGTACCTTTTAT

GCTTGANAAAANGAAANTNGGGGGGTTAAACCCATTTNAAAGNNNCATGNAATCATGGT TNGGAAAAGGCATTΓGGANTNCNTTTGGAGTTATATATAGGAACCGGCAAGTTΓTTGGAG TTGAATCCTTTTAAACATGCCGGACANAATAAAAAACCTTNGTTTTGNNAAAANNNGGNC CCCCCANTTTNTSITNAAANGGNAAANNTT^^ CCA

NCAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCGACAGATAGCCGACTTCTGTGCTGTGCCAGCCGCATCCCTGAGACAAGATGGTG AAGGTCGGAGTGAACGGATTCGGCCGCATCGGGCGCCTGGTCACCAGGGCTGCTTTTAAT

TCTGGCAAAGTGGACATCGTCGCCATCAATGACCCCTTCATTGACCTTCACTACATGGTCT ACATGTTCCAGTATGATTCCACCCACGGCAAGTTCAACGGCACAGTCAAGGCAGAGAACG GGAAGCTCGTCATCAATGGAAAGGCCATCACCATCTTCCAGGAGCGAGATCCTGCCAACA TCAAGTGGGGTGATGCTGGTGCTGAGTATGTGGTGGAGTCCACTGGGGTCTTCACTACCAT GGAGAAGGCTGGGGCTCACTTGAAGGGTGGCGCCAAGAGGGTCATCATCTCTGCACCTTC

TGCCGATGCCCCCATGTTTGTGATGGGCCGTGAACCACGAGAAGTATAACAACACCCTCA AGATTGTCAGCAATGCCTCCTGCACCACCAACTGCTTGGCCCCCCTGGCCAAGGTCATCCA TGACCACTTTGGCATCGTGGAGGGACTTATGACCACTGTCCACGCCATCACTGCCACCCAG AAGACTGTGGATGGCCCCTTCCGGGAAGCTGTGGCGTGACGGCCGANGGGCTGCCCANAA TATCATCCCTGCTTTCTACTGGCGCTTGCCCAAGGCCGTGGGGCAAGGTCATNCCTGAGCT

CAACGGGAAGCTTACCTGGCATGGGCNTTCCGGGTCCCACTCCCNACGTGTTTGTTGNGG ATCTGACCTTGCCGCCTGGGANAAACCTTGCCAGTNTGATGANANCAAAAAAGGNGGNG AAAACAGGCGTCAAAGGGCCCTTTCAAGGGCATTNTAGGCTTCNCTGGAGGANCAGGTTG TTTCTTGNAAATTNAAAAGNGACACNTCCTTT

ANCAANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCAAACTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCCTGCCTGGAC TCCGAGCTGACTGAATTCCCCTTGCGCATGCGGGACTGGCTTAAGAACGTCCTGGTCACGC TGTACGAGAGGGACGAGGACAACAACCTCCTGACCGAGAAGCAGAAGCTGCGAGTGAAA

AAGATCCACGAGAATGAGAAGCGCCTGGAGGCTGGCGACCATCCTGTGGAACTGCTGGCC CGGGACTTCGAGAAGAACTACAACATGTACATCTTCCCTGTGCACTGGCAGTTCGGGCAG CTGGATCAGCACCCCATTGACGGGTACCTGTCTCACACCGAGCTGGCCCCACTGCGCGCCC CCCTTATCCCCATGGAACACTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAACGA CAAGTACATCGCCCTGGACGAAGTGGGCCGGCTGCTTCGGCATCAAGGAGAAGGACATCG

ACAAGGACCTCGTGATCTAAAAGCCATGCCTCCTCCTGCAGAACCAGATTCTCTCTCTTTG ACTTTCCCCTTCTGTTTTTCCCAATGTTTAAAATGGTTGGATGGGTTGTTGGTCTTGCCTGG GGTCAAGGGGCTAATATAGACTTAAACGAATACCNTTAACCGGGGCTNAACACAGAACTT TTTAANCCAAGTWCGAAATTNNTTAAGTG^ CCCATGAAANGGGCCCCGTTTI CTTTTTGGCCGGGGNGCCCCTTCCNCCCTTTGGNTTTN

GGGGGGCNAATTGGGNGNGGAACACTTTNNNTTTGGTTNNNGNTTTNNCCNTTAAAAN^ CAATCGGGNATTTTTNNAANATTTTNAATO^ NNCCKAAANTTTGGGTTTANTTTTTTTNNNGGGGGNNTGGGCG GCCCTATANGGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGNCACGAGGNTGNAATGTNCTNTNCNGACTGNNNGNCNCNCNCANGATA NNNANGGNAGAAGOSINACCTNGTGGNGCTTTGGGCCCNNCTGGGGACAANNTCTAGCCC ATNCNTCACTCTATTGNNACTCTTNCAGGGCCTGGAANCCCTTGNTCCTATNTTCTNCTNG

NGCTAGGGGCCTGNGCTTNNCNANNCCGNCNGGAAAANGGANNGATNNACCCAGGGNGA NNN(^GGAAATCAAANCTNANTGGAAAANCNTNGCCCNNNNCCCAGGNGNGNAATTNNG CCTGNANACTGGNNGACCATGATGACNNTGAGGNTGTGGTNGNNAGCCACNAGGGCCTT CAJS[NAGNATGNAGNNGNGTTGGTTTTA(^CGANTGCCNGGGCTACCAGTTTTTTCAAATA TGTrWATTGNTGCCGTNCCCCCαSfCCCTTNNNNTNGGTNNATANANNNNCTTNTGT^^ σSINCNACCNTNCACANAGAGATTAACNNAAGNCTTANTGTCCCNANAAAANTGNTTAAA NCNCCCNGGAGCAAGGGTNCNTNOSlNATNGAαsrATTTTTTCCCNATT^ TTATANATCCNGNTGNTNCCCTTCCTTTTCATCTTNGNCATNCCAGATANTACNTGGTGNG ATGGGNCCCCCNTCTTNNCANNTNNCT^WTTTNGCANACCANGATCNGTNNNGNANTNNT CCAAAAACANNCATTCCCTTNATTTNNANTATTNTTNCTNGCNNAANATCNNN

AATNGNNNATTCNTCNTTTACCTTNNANΓWGGNTAATTATANNTTGGGCNATGTGTTTCTT NCCTGNCGACCNTNCAACNTNNCTGTAATNATTNTTTANTTNGGTANTNTTACATCCNNCA NNTNTNTTAATANNATN( NNTGTCCNANTTNATTAATNNNTATTNrWACTAA^ NTCAATTCNTNCNTCCG

TTNAGNCCTANNNTGNNTCNNTNTNNAAANGNANNACNCTNTAGAACTAGTGGATCCCCC GGGCTGNAGGCAAN(^GACAαsrAGGNNNTTCTGGGNCANTAGCAAAAGTATCCCTNTTTA GGGGNATNTNNATGGTNNGANTNGAANNGGTTNAAAACGATNNGAACGNCTTGNTCTAA AAGGCTNGGNNNCANNNNCCGGAAAANNGACANANCCTANCTNTTTTGNNTNGCTTAAN

CNA<^TNNTTTNAANCTAAGNCNNGNC^^

NNANNGTNCCNANAGNAANAGATCGGCATTTNNNTATANCNGNGNGANNGCGTCNATCC TATTTTTTGTGNNGGGCNAAATGGNGTGACAANNTAGNNNGGGCNNATGAANGGCCTCAT TNATANNTNGGNANTCACAACAGGGGTANNTTTTNTNGTNNTNNGAANCTNGNTNGCCCA TNNTTGNNAAGNGTNTGCTCCAAAANANTTATAAAANNTNNTNACNACGCNCTTTGNGCG

AGNGTCCCCCCTTANTTNTNTNGTGTCNGGNNCTNTGCAAα^CNCNNAAGTAANTAANNA AGANCTCTCAT^INNTTAGNNNNCNANATTGNCATATNNTNNCTTNTNATCCCTAATCTCTA TGNANNNANCCANNNTNCTCANNATTNTTTCCAACAATTCCNCTTTTTNTCNNTTAN TCGNNANCCATNTNTNCNANAAGTAGTCGNN^ NTAGTTGNGTTNNTCNNNNTNNNTATT^

NNTNTAGCCTTACTTANGAACA(^TNAACTTTCTTNACTNTATTCTCNTNTTTT^ TGGCTGCT(^AAANACCNTNTCTTTCTCNAATGACANNANTCGGNNNCANATTTNTATTA GGTNNNTTACNCCTNGTNNCNCCTTTTTAATCTNTTTNTCNNNNT^ ACNCTCGCTTTNNNNTGNCAAATCCCNCTANTTTNNNCCCANATCCNCGCNCTNNNNCAN ANNGTTNATNNNTATTNAGANNTCCCNNNACATNTNTNCNNCG

TTNAGNCCTANNNTGNNTCNNTNTNNAAANGNANNACNCTNTAGAACTAGTGGATCCCCC GGGCTGNAGGCAANCNGACACNAGGNNNTTCTGGGNCANTAGCAAAAGTATCCCTNTTTA GGGGNATNTNNATGGTNNGANTNGAANNGGTTNAAAACGATNNGAACGNCTTGNTCTAA

AAGGCTNGGNNNCANNNNCCGGAAAANNGACANANCCTANCTNTTTTGNNTNGCTTAAN CNACNTNNTTTNAANCTAAGNOWGN(-MWTTNANNTNCNCN(^AGGGNATNGN^ NNANNGTNCCNANAGNAANAGATCGGCATTTNNNTATANCNGNGNGANNGCGTCNATCC TATTTTTTGTGNNGGGCNAAATGGNGTGACAANNTAGNNNGGGCNNATGAANGGCCTCAT TNATANNTNGGNANTCACAACAGGGGTANNTTTTNTNGTNNTNNGAANCTNGNTNGCCCA

TNNTTGNNAAGNGTNTGCTCCAAAANANTTATAAAANNTNNTNA(^ACGCNCTTTGNGCG AGNGTCCCCCCTTANTTNTNTNGTGTCNGGNNCTNTGCAACNCNCNNAAGTAANTAANNA AGANCTCTCATNNNTTAGNNNNCNANATTGNCATATNNTNNCTTNTNATCCCTAATCTCTA TGNANNNANCCANNNTNCTCANNATTNTTTCCAACAATTCCNCTTTTTNTCN^ TCGNNANCCATNTNTN(^ANAAGTAGTCGNNGATNNNATTATTNCCGCNCTNNGNNGATN

NTAGTTGNGTT1SINTCN1NINNTNNOT

NNTNTAGCCTTACTTANGAACA(^TNAACTTTCTTNACTNTATTCTαsrTNTT^ TGGCTGCT(^AAANAC(^TNTCTTTCTC^AATGACANNANTCGGNNNCANATTTNTATTA GGTNNNTTACNCCTNGTNN(^CCTTTTTAATCTNTTTNTC^^ A<^CTCGCTTTNNNNTGNCAAATCCCNCTAN^

ANNGTTNATNNNTATTNAGANNTCC(3S1NNACATNTNTNCNNCG

TNNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGAATTCGGCACGAGGCCCCTCCCCCCGAGCGCCGCTCTGGCCGCACTGCGCTCG CCCTGAGCTCCGGGCTCCTGCTAAGCCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCAT GATCATCTACCGGGACCTCATTAGCCATGACGAGATGTTCTCCGACATCTACAAGATCCGG GAGGTCGCGGACGGGCTGTGTCTGGAGGTGGAGGGGAAGATGGTCAGTAGGACAGAGGG TAACATCGATGACTCGCTCATTGGTGGAAATGCCTCCGCTGAAGGCCCCGAGGGCGAAGG

TACCGAAAGCACAGTAATCACTGGGTGTCGATATTGTCATGAACCATCACTTTGCAGGAA ACCAGCTTTCACAAAAGAAGCCTACAAGAAGTACATCAAAGATTACATGAAGTCAATCAA AGGGAACTTTGAAGAACAGAGACCAGAAAGAGTAAAACCTTTATGACAGGGGCTTGCAN AACAAAATCAAGCCCATCCTTGTTAATTTCAAAAACTATCAGTTCTTTATTGGTGAAAAAC ATGAATCCAGATGGCATGGTTGCTCTGCTGGACTACCGNGAGGATGGNGTAACCCCATAT

ATGAATTTTNTTTAAGGATGGGTTAAAAAATGGGAAAAATGTTAACCAAAGTTGGCAAGT TA(^TTTGGAATCAAATCACCTTGTCGGCATAAACTGGCTNGGCTACTGGGTTTTCATTCC CCCCCACCACCAGGACTTTAAACAGAANGGGAACTGGATGTCATTCTCGAGCTTTTTANTT TGGTTTGAACCGTTGANTTAATTTGGAGCGGGNGGCCTTTGTTTTTTGANAAAAACGGGTC ATGGGAGGGTGGCTTAAAAAANAAAACNCCTTTTAAACTTCNTTGGNAAAAAAAAAAAA

AAA

AANAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATNCCCGGGCTGCA GGNANGATCNANCNNGTCCTGCCCAANAAACAAANGCNTAATCGGCCCATNGGTTAATG

GATTCGNNATGAAAACTGCCAGNTATAATCAGGTACAACTNCANGAGAAGACATTGGATA

AAGAACCAAGCTGNNCTATNATAAGCANGCTGGGTCTATGANANGTGGCCTTAACATGNA

GACCACTTTTTITAAGCANNCANATGACATTGAAAACNTCACTTACTGNNNTGCNTCGGCC

CATGANGTTATTTCCTTACTATNAGGNTTGAAACCCATCCAATAAATNTAAANCCNNGGC AAAAAAAAAAAAAAAAANTCCNNGGGGGNCCCCTNNCNCANANANTCCCTTAAAGTAAA

ATTGTTTANANAGANCANTCNATCTTGNNGCTTTTNTTTNCCNCNTNNGCAATNCATNCAN

GNNTNNCCCCCNTTGGNGGNNTTTTTO^

CGNANTTNCTNTlSINC rATNCCAN^

ANC(_HNATTANAAANNCACACTNNGNNANCANTTTATAOSINNTC^ NNCTTNTTATTTTTNT TAACGNCA^

NTCTTATTATAATTCTCTNTTNNGTNCC^

NCTTCTTANNCATNTGTTOSINNNαsrNCTATTTTTTNNTTC

TNNATTNTNTCTTAAATTNNCGNNNTNATTCTTATTTNCTC^

ACTANCTTTTATCTTTATTCNTTTCTOSINTCATTANAANNCTTCATTTTTC TTANTTNGTTGNGNNTCTTC^CTCT^

TNTCTACGNTNGAACNTCTCCNNCNTCCCNCG

TTGNANACAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGATATCAAGCTTNTCNNTACCGTNGACCTGGANGGGGGGCCCGGGT

CNCAATTCGNCCTATAGNGNNNCGGANTACAGTGGGAACGGCGTCACAATGATGACTGG ACGGCAGGGCCGAGCTACCTTCCAGTTCCTGCCTGATGAGGCCCGGAGCCTGCCGCCGCC GAAACTGACGGACCCGCGGCTGGCCTTCGTAGGCTTCTTGGGCTACTGCTCCGGCCTGATT GATAACGCGATCCGGCGGAGGCCGGTGCTGTTGGCCGGTTTGCATCGCCAGCTTCTATATA TTACTTCCTTTGTTTTTTGTTGGATATTATTTTTTAAAAACGTCAAGA

GTGAGGGACCACGATATGTTCTCATATATAAAGTCACCATNCAGAGGATTTTCCCTGAAA AAAGATAAGAAAAACTTACGGGGAAGNTTTTTGAAGAAATTCCATCCAGGGGCGTTGAAG TTCTTNCAAAATGGTTTTGCCTCCCGGTTTAATT^^

GTGGAACTGGTTTCTTATGAACATCTTNAAAGTITTATGTTTNANTTTTCTTT AACCCCCTTGNTGATTAAAAATTGGT(^ATTNTAAAAAAAAAAAAAAAAAAAAAACNTNT

NNGGGGGGGGGGCC(^CNαsπsrCCCCNNTNTTTTTCCTNTTNTTTGGGAN TCCNCTTNNTTTTCCCTCMSπS[NTTTCTNTA(^TCTTNCTNTπ CTTTGCTNTNTNCTN^TACTCTT^^ ATTNNT>nSlNNCCTNTTANrN^ πCTCCπCTATCTNTCATCTCNCTC CNATTNCTTNCCT

TTGAGNCCATANGGAGNTGCANNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCTGNTGNGGNATNTGGAACANNTCGNTGTACTGAGGCNGCGGNCGCTGANG CCTCANGGAGGGCCTGAAGGGACCCCGGCAGCGCCCCCCGGAGTGATCCAGACACTTCCA ANAAGGGGCCGNCGCCACCTGTGTATATNACCTCCTGGTACCACTGCTACACTTANCANC TTTTTTACTTTTGAGGCTTTGTNNATGTCCTGAAGCTGCCTGNNAATTGTCCTTT^

GACGTCACNTGTANGGGCCNTGTGAGTGGGCCNNGGGGACTGCAAGGCANGGCCCCCCTT NTGNTGNTNGNGGGCTCTGCTTGCTCATCCAGGCCTCTCCTGGGGGCCACCCAGNGCCGC CCANTCCAACTGCACCCACGCGCCCGTCCCCATGAGCGACACACACGGCTCAGCCTTTTTT TAATACNTGATCCTTTNNCGGCCACCTCGCTNTGGAGCCGNGTCTACCAGCAGNCTTATGC CTTNAA<^CGCACCTTTCNTTTNTAACGCTTTAANNTTAATTGTGATTNCC

AGTCCTTCAATAAAAGANNNGAAAAACCCAAAAAANAANAAAAAAAAATTTTGGNGGGG GGGGNACCCGATCCCCσsfTTTGGCC(^TNAANGGGGGATNTCTTTNTANAAANTNGTAGG NAAANAANNTTNNGGNN WGCTNAAAACTTTTAAATNNGGNNGGNANTTN^ TAATACCC^CACCTNTTGNAAAANNGATTTAAATTGGGAANAAATTGGGCAANAC^CTTT TNNGN(^TTNGNCCCTTCGGAAANCNGAANTGNN^

1NINNTTTTTNNTNNGANGGA NNTAGTTTTNTNGGNTAAAAAATN

GCCTATCTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCTTGGTGATAAGGCTCCACCAAAGCCTGTACCCAAGACTATT GACAACCAGCGAGTATATGATGAAACCATAGTAGATCCTAATGATGAAGAGGTTGCTTAT GATGAAGCTACAGATGAATTTGCTTCTTACTTCAACAGACAGACTTCTCCCAAGATTCTCA TCACTACATCAGATAGACCTCATGGGAGAACAGTACGACTCTGTGAACAGCTCTCTACAG TTATACCAAATTCGCATGTTTATTACAGAAGAGGACTGGCTCTGAAAAAAATTATTCCACA

GTGCATCTCAAGAGATTTCACAGACCTGATTGTTATTAATGAAGATCGTAAAATACCAAAT GGATTAATTCTGAGTCACCTGCCCAACGGCCCAACTGCTCACTTTAAAATGAGCAGTGTTC GTTTGCGTAAAGAAATTAAGAAGAGGCAAAGACCCAACAGAACACATACCAGAAATAAT TTTGAACAATTTTACAACACGACTGGGTCATTCTATTGGACGTATGTTTGCATCTCTCTTTC CCCATAATCCTCAGTTTATTGGAAGGCAGGTTGCCACATTCCACAATCAACGGGATTATAT

CTTCTTCAGATTTCACAGATACATATTCAAGAGCGAAAAGAAAGTGGGAATTCAGGAACT TGGACCACGTTTTACCTTAAAATTAAGATCTCTTCAGAAANGGAACCTTTGATTCTAAATA TGGGAGAATATGAATGGGTCCATAAGCCCCCGGGGAAATGGGATCCAGTAGAAGAAAAA TTCATTTTATNAANGGACTGGAGAAGGATGGTATTAAACTGGGCTGGAACCAGGCCTGGA GTTTTTGAAAACAAGANCTTNTCAAAAATGGNCGGTTACT^

TCTTTTCTGGACCAAAGGNGCAAGGGGCCTTGAATTTNCT

NNCNATCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGATGGCACGTCCCCAGTGTGGGGATGTGCCGTGCTTCCTGAAT

TAGTGTATTGTAGGAGTTGCTGCCCCATTCTGCTCTTCATTGTGAGAGAGGTTACACCCAC TTATAATCAGTATTTTCCTGGCACTAAAACAGCAGGGCTGGTATTTGCTGCTGCTTTCCCA GGGCAGGGTCCCTTCTTTΓCGGCACTTTTGAACACTTGCAAGACACAGCCCTGTTATCTAA CGGGTGGCAGGCATGTGTGTCTGCACTCGCTCTTTGCCACTATTTTGCCCTGCTCCATGCC ANAGAGCCCTGTCCCTGCCAGGCCCTGCCTTCCCAGCCCCAACTTGGGACCAAAGTGCAA

GACGGGATCACAGGTTGGGGTGTCCAAGTGACCCCTTTCTATAAGTGCTTCCGTGGGCCA AGTCGACACCAGCCCCCTANCGGNGTGGGATGGNCGGNGCTTAAAGAGGAAGGGGACCA GTGTAGCAACCTTGCCAGGGACCCCACCCCCTCCCTTACATCCGGACCCTGTGCAGTGGGC CGTGGCGATTCTCCAAAAGGGGCCAAAAGCCTGGGCTTGCTCNGTATTCTCTGCTCCCTTG CTCTTATCNGGTCNCCATGCACACTTCTAAGANTGCCAAATTGCTTTTGAACTTTAAAAAC

TGGTCANNNTTGGNTTCCCNTTTGGACCNANTTTTAAAAAAANGTTCTNAATNGGGAAAA AATTNGNGGGGAAAAACNNTNGGNTAAANGG<^CCGGGNTCCTTTGGCTTNTCGGGGGA AAAANACANGNGCCTTTTCCGGAGGGAACC(^CTTTTTCCNCACNTTTTCNGNANGGTNC CTAAAACCCTGTCCACCCCCCTN(^AAANCCTTTNGCCCNGANANTNNNNCCCGGGGTTC TCNNTAACCNTNTNTGGGCCCGNGGGTGTTTTTTTNTCGGANAATNTCTGNNNC

GCCCTATNTGGAGCTNCATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGGGCAGAAGGTTCGCGAGGAGGTGGTTACCGTGGGCAATTCT GTTGACCAGGGCCTGAGTCAGCCCACAGATGACTCCTGCTTCGACCCCTACACGGTCTCCC ATTATGCCATTGGAGAGGAGTGGGAGCGATTGTCTGATTCTGGCTTTAAACTCTCGTGCCA GTGCTTAAGCTTTGGCAGTGGTCATTTCAGATGCGATTCATCTAAATGGTGCCATGACAAT GGAGTGAACTACAAGATTGGAGAGAAGTGGGATCGTCAGGGAGAGAATGGCCAGATGAT

GANCTGCACGTGTCTTGGAAATGGAAAAGGAGAATTCAAGTGTGATCCTNATGAGGCCAC GTGCTATGACNATGGGAAGACTTACCACGTGGGAGAACAGTGGCAGAAGGAATATCTTGG TGCCATTTGCTCCTGCACATGCTTTGGAGGCCANCGGGGCTGGCGCTGTGACAACTGCCGC ANACCTGGGGCTGAACCCGGTTACGAAGGCTCCACTGNCCACTCCTACAACCAGTNTTTC CCAGAGATNCNCATCANAGGAACAAAACACTAATGTCANCTGCCCAATNTGANTGCTTCA

TGCCTTTGGGATGTACAGGGCTNACNGAGAAGAATTNCCCGAGANGTTATTTTTTTCNCAA NCCCANAGNAAAαsrTNGCGTTGGNTTTCTTGCCANAGGTNCCANTCCCAAANCTGGGANT GGGGGTTNNCACTACCCCCCTTGNTNAAGTGGGNGCCCTTTCTTTNAGCCCNTTTNNCTTN TGGNNNNAANTTTTTTT(^GTTTTTTTCCNTCAACCCCNC CCCTGGGAGGNGTTTTTTCAAGACTTTTTTTTTCATTANATTGGGGNNCC

TTTNAGCCTATNTGGAGCTNCATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCTGNATTGNCCCTANNCANGGCTGCTNCNNGGATGNC ATTAAGGTNTTCTGCAACATGGAAACCGGTGAGACCTGTGTATACCCNANTCANCCCANC

GTGGCCCAAAAAANCTGGTNTNTNANCAANANCCCCANGGAAAANAGGCNCGTTTGGTN CGGCAANANCNTNACCGGNGNATTCCANTTCAANTATGGNGGCCAGGGGTCCAATCNTGC CAATGTGGCCATCCAGTTGANTTTCTTGCGCCTGATGTCCACCGAGGCCTCCCANAACATC ACTTACCANTNGCAAGAACAGTGTGGCTCTANATGGACCAGCANACTGGNAACCTCAANA AGGCNCTNCTTCTNCAGGNCTNNAANGATATCGATATCNGNGCCGAGGGCAACAGCCNTT

TCATNTACAGTGTCANNTANTANGNGTGCANGANTCACACCGGACNNTGGGGCAANACA GTGATNANATACAACCACCCNCAAGANCTCCCTTNTTGCATCATTATATGATGNGCCCCCC TTTGGGACGTTGGCCCCCCAACACCAAAGAAATTCTGCTTCCGACGTTGGCCCTTGCCTTG CTTTCTGGAAAACTTTCTTNCCAOSfACAANTGTTGTTTTCCTTCCCACNCCAANACCNT^ TGCCTNNTNANTNTTGGNAAACAAGAACAAACCCCCCCTTGCTTGGCCCCCCCCCGNAAC

NGCCCAAAAGGNTGGGAAAACTTTTTTNTCGTNGGNCOT TTTTGCATTCNTTTTNTTCAAAAATTAAT^^

AAAAACCCAGGGGTTCNNTCCTTNCTTAACAAAAAAAAAAAAAAAANCTTNGGGGGGGG GGCCCCCCCCNCCCCN

TTTNAGCCTATNTGGAGCTNCATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCTGNATTGNCCCTANNCANGGCTGCTNCNNGGATGNC

ATTAAGGTNTTCTGCAACATGGAAACCGGTGAGACCTGTGTATACCCNANTCANCCCANC GTGGCCCAAAAAANCTGGTNTNTNANCAANANCCCCANGGAAAANAGGCNCGTTTGGTN

CGGCAANANCNTNACCGGNGNATTCCANTTCAANTATGGNGGCCAGGGGTCCAATCNTGC CAATGTGGCCATCCAGTTGANTTTCTTGCGCCTGATGTCCACCGAGGCCTCCCANAACATC ACTTACCANTNGCAAGAACAGTGTGGCTCTANATGGACCAGCANACTGGNAACCTCAANA AGGt^CTNCTTCTNCAGGNCTNNAANGATATCGATATCNGNGCCGAGGGCAACAGCCNTT TCATNTACAGTGTCANNTANTANGNGTGCANGANTCACACCGGACNNTGGGGCAANACA

GTGATNANATACAACCACCCNCAAGANCTCCCTTNTTGCATCATTATATGATGNGCCCCCC TTTGGGACGTTGGCCCCCCAACACCAAAGAAATTCTGCTTCCGACGTTGGCCCTTGCCTTG CTTTCTGGAAAACTTTCTTNCCA<^ACAAOT TGCCTNNTNANTNTTGGNAAACAAGAACAAACCCCCCCTTGCTTGGCCCCCCCCCGNAAC NGCCCAAAAGGNTGGGAAAACTTTTTTNTCGTNGGNCNTT^

TTTTGCATT(_^TTTTNTTCAAAAATTAATTTTT^^

AAAAACCCAGGGGTTOS1NTCCTTNCTTAACAAAAAAAAAAAAAAAANCTTNGGGGGGGG GGCCCCCCCCNCCCCN TTGANAANAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCCCNTCCCCCCGAGCGCCGCTCTGGCCGCACTGCGCTC GCCCTGAGCTCCGGGCTCCTGCTNAGCCAGCGCCGCTGTCNCCTCCCTCCAGTNGCCATNA TGATCATNTACCGGGACCTCATTAGCCATGACNAGATGTTCTCCGACATCTACAANATCCG

GGAGGTCACGGACGGGCTGTGTCTGGAGGTGGAGGGGAAGATGGTCAGTANGACAGAGG GTAACATCNATGACTCNNTCATTGGNGGAAATGCCTCCGCTGAANGCCCNGANGGCGAAG GTACCGAANGCACANNNNTCNCTGGTGNCANTATTGTCNTGAACCATNACTTGCANGAAA CCAGCTTCACAAAAGAAGCCTACAAGAAGTNCATNNAAGATTACATGAAGTCAATNAAA GGGAAACTTGAAGAACAGAGACCAGAAAGAGTAAAACCTTTTATGACAGGGGCTGCATA

ACAAATCAAGCACATCCTTGCTAATTTCAAAAACTATCAGTTCTTTATTGGTGAAAACNTG AATCCANATGGCATGGTTGCTCTGNTGGACTACCGGGAGGATGGTGNAACCCCATATATG ATTTTCTTTAAGGATGGGTTAGAGATGGNAAAATGGTAACAANAGTTGGCAGTTACTTTG GATCAAATCACCCGTCGGCATAACTGACTGGGTACTGGTTTTTGGTTCCCCCAGCACCCGG GGTTAGGCGGAATGGGACTGNTGNNAAANTNGGGCTTTTTTNTTTTGGTTπ

AATTTATTTGGGNGCCGGNGGCC ITGTTTTTNAAAAAANCNNGCCNTGGANGGGTNGGC CAAAAAAAAAAACCCCGNTTGAAACTTATTTGGCAAAAANAAAAAAAAAT

TTGAANAACAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGNTGGGCTCAACCTGGCNTCTGGAGTTTAGTCCCCGCNCTGCTGTGNGCGN AGCTGNTGTCTGCTTNTAGGGNCGCAGNGACTGCTGTCGCATCGGGATCTTGATCGTGATG GGTACAAAGGCGAAAGTCGGCAGTACAGAGTTGCTTCTCTTCACGTCGATGATCCTGTGCT CCCTGGCATTGGGCAGGGGTGCGGTGCAAACCTATGAACCGGTAGTCAGAGTNCCTGAGA ATAACCCTGCCAAGCTGTCCTGCTCCTACTCGGGCTTCTCCTCGCCACGTGTGGAGTGGAA

GTTTACCCATGGNGATATCAGAGGTCTCGTTTGCTATAACAACAAAATCACTGCTTCCTAT GAGAACCGAGTGACCTTCTCGGATACTGGCATNACCTTCCATTCTGTGACCCGGANAGAC ACGGNNATGNATACCTTGTATGGNCTCTGATGAGGGCGGCAATACCTACGGGGAGGTCAC CGTCCAGCTCATCGTGCTCGTGCCTCCATCCCAAGCCTACAATCAACGTCCCCTTCTNTGTT ACCATTGGAACCCCGAACTGTGCTGACCTGGTTNANAAAAGAAATGGCCTTCCCCCCCCA

TCTGAATACAAGTGGGTTCAAGGGATTGGAGTTAAAAAATGCCTTTTGGGAACCCCAANA NNCAAACCGNGGCCTTTTNAGCNAAACTCTTTTCTTACACCCTTGAAACCAAAAAAAANA NGGGGAAGTTGAATCTTTTGATCCCCGNGTCNGGCCTTTTGACACTTGGGAANAATTCACC CTGGTCAGGCCACANNAATGGGCTTTTGC^TTNCCCCCCNNGAAATTCNAAAACNCCCGG GGCCCCAATGGGANTGCTTTNGGGANGCTTTAATTGTTTGGGGGGGCAATCNNGGGCCAN

ACCTTTNTTTTTGGAAANACNTTNATTTTTNCTNGGGAACCT

TTTGANAAANTNNNNNTGGGGCNNNNNNNCNAGGGGTANNACACTTATAGGANTGCGTG NNGACANCNACGGGCTGCTATGNAATCCTTAACNNTNNTACCTTTTCTCCTCATTNANNTC

TGCCTNCCTTCCTTANGGGGNCTTTTNTNAANNTGACTTTTANNCCNANACCCCCACNNNN

ACATTTATCANACNCTTANNNTNACCTTTATNNNCACTCANTAGNTNTCANCACATNNNCC

TCTOSINCACTCGATNCTNGA^CACCTN^

ATTTNATNNANACATCANTTTAACC NGCNCTCNTNCACGACANNCTNTTNTNCACGTNA NCACATGNTNTTNNCTCTACANCCNTNNAT^ αWTGACGTNNNCCACNCTANTATNNCT^^

ACNTCACATGANANNCNNTNGAN(^TNNCATGTCTACNNANCNCTCTCTNCNTCTCTCNN NTCATCNNNNGATATNNTNTNTCNNCTNACNCNCNCNANTCTCANACCCNGNTACTNCTT ANACATGACTNACCTCNATCNTNANNTTCGCN(^ANC^ TCTTTNNNACTCTANOSfNTNACCGTO^

NNNACTNNCHNGTGATNANNNGNNACTCNGGCTANATCCNNNNTANATTCTANTCCANTN NNTNCGTCTANCTCACGTANACNCTCCGACTNTCNACNACTATATNTGNTNNTATGANCA ACTANTCNCATNNGNACTATGANATAACNCATTCNCTAGTACCTACNANTCAGTATCNGT AGCCNTCTTANNTNNTAANNTCTAt^GATNTGGANNTCACTAGTANTCNCGTCNNCCNNG ATTNTACAAGATTCNNCTACTCCNCTAACNATNNNACTCCAATACGTNCNCTAAGNCNAC

NNT WCTNTCCAATTACTNNTAATCNCCCNTTNTATCTCGANNCNCCTNTNCNANCGANG NAANNTCCANCC(^TA(^TATNTAATGANNCTNNTNTNGANTTNTATTAGTNTCATTNCTT GTACCTNTA(^TNGAGCNATTATCTNGCACTACGNCNAAGTTATNNACNNNCTNC3WACT ANNAANTTNTATGCTATANANCTACNOSINTATCTNCNCNCNTTCNTCTN^ TGGANNTACTANTATGCTATNTACNNNCNNTATNTACACTCACTGGATNATNTNCTACTTC CαSfTNCANTTTACACNCTANGNTCTCCCGAAAGNNCGCCCCATCTAATTACCANNCTCCTC TCCANCGNNCGTNNGNANCACACANAACATCTACGCN

GCCTATAGGGAGNNGCATTACAGGGGNCGGCCGNTCTANAACTAGTGGATCCCCCGGGCT GCAGGATTCTGCCCGTAATGACTGTGGTGCTGCCAGAGGGATTTTTTTCCCCCTTTCAATG GTTTTACTTAAGTTACTGGATAAGCAGTTGAGTTTACATTAAAACAATGAAATGCTATATC TTGTCTATATTCTGCCTCTTCCAAATTGGATGTTTTTTTTTTTTG CTTNANAANNTTTTNANGGGGGNNNNGGNAGAAANGGGNTAAAAAAAAACCGNCNNNCT

TTNAAANCCC(^GGGGNACCCNGGGGGCNNNCCNTTNNNGGGGTGCCNNAAANCNGNNC NCAATNNANGGNNNTNACNNNA(^ANACCTTCCCNTNNNNNNGGAANGGNNGGGNNGN ACCAAANCNTTNCNNGTGGCAANGGNTNNNTTAACNNCNAAANTTNTC1TNATTAANATA NGNANCCCNNGCNTANCCNNNGNCCCTAANTAAAANNGGGCCCGGGTNGNACCNTTTAT NGAAAAGNAANGGNACCCCMNCTTM^ANTTTTTT^

TNGNGGCC^TNTTTTTAACNNNGGGNGNNGGGAAANCCTTTTGNAAANNGAGGAATNNC TTCTTNAAGGATTTTNNGATTTCCNCCCTTGNCCCNNANANTNTAGCCCANTTTTTGGG AAAAACTANGGGGOSπsπSlNNGNNNGTAAANCCAAANGGGAAAAAANGGCNCGNCTCNGG GTTTTNNAACCCCCAAAGGGGNAAACCCGGTTNNTGCGGNGGGTNCCCTNCGGAAAAAAT TNGGGGTTNNNCCCCCCCNCCCCTAANNTTTTT^^

CAAAANNCNACCCCNTGGGGCNANTTATCNTNTAAAAAANGGNTTCCCCCCTNAANAAA AAAATANNTTCCCCAAAACNTGCCCCNGNGGNAAAANNTNGNCNNANCAGGAAATTTTN ACC

TGAGCCTANTGGAGNNGCATNNCAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACNAGGNTCCAGCGTGCCTGCTCCTCAGCCATGGNGCCCTCCAGGA AGTTCTTCGTTGGGGGGAACTGGAANATGAACGGGAGGAAGAACAATCTGGGGGAACTC ATCAACACTCTGAACGCGGCCAAGGTGCCAGCCGACACCGAGGTGGTTTGCGCACCCCCC ACCGTCTACATTGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCCGTGGCTGCGCAN

AACTGTTACAAAGTGGCCAATGGGGCCTTTACGGGGGAGATCAACCCTGGCATGATCAAA GATCTTGGAGCCACGTGGGTANTCCTGGGGCACTCCGAGAGAAGGCATGTCTTTGNGGAG TCAGATGANCTGATTGGGCAGAAAGTGGCCCATGCCCTTGGCANAGGGACTTTGGAGTNG ATTGCCTGCATTGGGGAGAAGTTACATGAGACGGAAGCTTGGCATCACGGANAAGGTCCG TTTTCCGAGCAAACCAAGGTCATCGCANATAACNTTGAAGGATTGGNAAGCAAGGGTTGT

CTTNGGCCTATTGAGCCCTGTGTGGGCCATNGGTCCTGGCAANGACGNGCNACCCCCGTA CCAGGGCCCAGGAANGTCACNGAAAANNCTCCCGGGGATGGNTTAAAGTCCAACNTTCTN NTNATGCNNTGGGCTNANAACCGCCCCCATTCNTTTTATTGGGGNTTCTNGTNANCGGNN NCAACCCTGCAATAGGAATTTTGCNAAGCCACCCNTGGATGTGGGATNGCCTTTTCTTTNT NGGGGCGGGGNCTTTTNCNTCAANACCNTI^NN^

CANTAANTCCTTGTNTNTTTTTTACTAC^^

NNNTAACNCTTTTTATTTTACTTNGCCCCCGGACTTTNCAANATGTTNNTCGGGN^ NCTNACCCNCN

NAAAAGCTGGAGCTCCACCGCGNGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

TTTTACTTAAGTTACTGGATAAGCAGTTGAGTTTACATTAAAACAATGAAATGCTATATCT TGGCTATATTCTGCCTCTTCCAAATTGGATGNTTTTTTTTTTTNGNAAAAAAT^^ CNTTNNNAATNTTT INNNGGGGNCTAGGGANNAANGGGGTNAAAAAAAANCNGCCNNCN

TTTNAANNCCCCNGGGNACCCNGGGGGNCTNCCNNNNNTGGGGT JNCNNAAAGNCGNNC CCAACNGAAGGNNCTNANCNNANCANAC(^TNCCCTNNCNNNNGNAAGGNTGGGGNGNA NCAAAACCTTTCNNNTNGCCANGGNNNGNTTAAANNCNAAANTTTTCTπ NANCCCNNGCNTAACOSlNNGTCCα^NAATAAAAAAGGGCC(^GGTNGNNCCCTTTANTG

GGCCC(^TTTTTNACAGGGGGGGTGGAAAACTTTTTGAAANNNGGGGTNCCACNTNAANG GATTTTNGGTTTTTTCCCCCTTGCCCCAAAANNTTNTTCCNNATTNGGGA^ GNTNTTTGNGNGOS[AACCTANNGGGGAAAAAAGGGGGCCCCCCNGGNGTTTTTTTACCCC OWAANGGGGGAAAACCCNCOSIT TTNGGGGGGGTNCCCCN(^GCHNAAA^ TTTTNTNCCCCCCCCCCCCNAAANGTTTTTTTTTAAAAANN^ AAACTACCCCCCHNGGGGNNNTNATTTTTTN

TTNAGNNTATCTGGAGCTCCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGANTTCGGCACGAGGCTTCAGCGTGCCTGCTCCTCAGCCATGGCGCCCTCCAG GAAGTTCTTCGTTGGGGGGAACTGGAANATGAACGGGAGGAANAACAATCTGGGGGAAC TCATCANCACTNTGAACNCGGCCAAGGTGCCAGCCNACNCCNAGGNGGTTNGCCCNCCCC CCACCGCNTACNTTGACTTCGCCCGGCAAAANCTAAATCCCAAAATNGCCGNGGNTGCCC AAAANTGTTNCAAANTSΓGGCCANNGGGGCCTTTACGGGGAAAATCACCCTTGGCNTGATCA

AAGATCTTGGAGCCACTGTGGGTAGTCCTGGGGCACTCCGAGANAANGCATGTNTTTGGG GAGNCANANGANCTGATTGCGCAAAAAGTGGCCNATGCNCTGACAGAGGCACTNGGAGN GATNGCCTGCATTGGNGAAAATTTATNTGAGNGGGANTCTGGNATCACGGAAAGGGTTTT TTNGACANACCAGGGTATCCATATNACGTGAATTATTGGAACANGGTTNTTTTGCCTATGA CCCTGTGTGGNCCATTGGTCTGGNAAGAACGGCACCCCGCAAGGGCCNAAGGAAGTNCAC

AAAAAGCTTCGGGGGATGGCTTAACCACCACCTTTTNTGATGCGGGGGATAAAAACCCCC CATTTATTTATGGGGGTTTTNGGGGACGGNGGCCCACCCTTGGAAGGGAGCTTGGCCCNC CCNCCCGGGGGGGGGNTGGTCTTTTNTTGGGGGGNGGGTTGCCTTCCCTTCAAAGCCTTGN

NTTTGGNTΗNNπsrCTTCATNN^ NCCTTTCCTGGNNNANNCCNAGGGG^tNTTNGNTTNNTTTAAANAAACCNTTNTT

TTNAGNNTATCTGGAGCTCCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGANTTCGGCACGAGGCTTCAGCGTGCCTGCTCCTCAGCCATGGCGCCCTCCAG GAAGTTCTTCGTTGGGGGGAACTGGAANATGAACGGGAGGAANAACAATCTGGGGGAAC

TCATCANCACTNTGAAα^CGGCCAAGGTGCCAGCCNACNCCNAGGNGGTTNGCCCNCCCC CCACCGCNTACNTTGACTTCGCCCGGCAAAANCTAAATCCCAAAATNGCCGNGGNTGCCC AAAANTGTTNCAAANNGGCCANNGGGGCCTTTACGGGGAAAATCACCCTTGGCNTGATCA AAGATCTTGGAGCCACTGTGGGTAGTCCTGGGGCACTCCGAGANAANGCATGTNTTTGGG GAGNCANANGANCTGATTGCGCAAAAAGTGGCCNATGCNCTGACAGAGGCACTNGGAGN

GATNGCCTGCATTGGNGAAAATTTATNTGAGNGGGANTCTGGNATCACGGAAAGGGTTTT TTNGACANACCAGGGTATCCATATNACGTGAATTATTGGAACANGGTTNTTTTGCCTATGA CCCTGTGTGGNCCATTGGTCTGGNAAGAACGGCACCCCGCAAGGGCCNAAGGAAGTNCAC AAAAAGCTTCGGGGGATGGCTTAACCACCACCTTTTNTGATGCGGGGGATAAAAACCCCC CATTTATTTATGGGGGTTTTNGGGGACGGNGGCCCACCCTTGGAAGGGAGCTTGGCCCNC

CCNCCCGGGGGGGGGNTGGTCTTTTNTTGGGGGGNGGGTTGCCTTCCCTTCAAAGCCTTGN NTTTGGNTNNNNCTTCATNNNNNGGCCCAAAAAANTNNNGCCCTGGTTTTTTTT^ NCCTTTCCTGGNNNANNCCNAGGGGNNTTNGN^

TTNANAANNTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGCCGAGAAGGCAACATGGGTCACCAGCAGCTCTACTG GAGCCATCCGAGAAAATTCGGCCAGGGTTCTCGCTCTTGCCGGGTCTGCTCCAACCGGCA CGGTCTGATCCGGAAATACGGCCTCAATATGTGCCGCCAGTGTTTCCGCCAGTATGCGAA GGACATCGGCTTCATTAAGTTGGACTAACCAAACTTCCTTAGATGGCTCATCCAGCACATC

AACCΓΓAGGCGGAAACAATACTAGCTCTTTGTATATAAAATAAAAGTTTTCAAAACTTCAA AAAAAAAAAAAAAAAAAAAAAACNCNNGGGGGGGGGGNCCGGGCCCCNANTTCCCNTN NNGGGGGGGNTNAAANAAANNNTSFNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNN πWNNNNNNNNNNN^

ININNNNNNNNNNNNNNNN^

NNNNNτ>!NNTSINNNNNNNNNNNNNN^

NNNNN τ>πsπWMN T^^

NNNNNlSπSlNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNISINNI^

NNNNNNNNNTSπS NNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNN^ AACAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCCGAGAAGGCAACATGGGTCACCAGCAGCTCTACTGGAGC CATCCGAGAAAATTCGGCCAGGGTTCTCGCTCTTGCCGGGTCTGCTCCAACCGGCACGGTC TGATCCGGAAATACGGCCTCAATATGTGCCGCCAGTGTTTCCGCCAGTATGCGAAGGACA TCGGCTTCATTAAGTTGGACTAACCAAACTTCCTTAGATGGCTCATCCAGCACATCAACCT

TAGGCGGAAACAATACTAGCTCTTTGTATATAAAATAAAAGTTTTCAAAACTTCAAAAAA AAAAAAAAAAAAAAAAAAANC(^TGGGGGGGGGNC(^GGCCCCCANTTCCCαfTNNNGG GGGGNGGNNAAAAAANNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNΓ>INN1SINNNNNNNNNNNN^ NININNNNTN SEN^

NNNNNTSINNNNNTSINNTSINNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNC

TNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNGNNAAGGNTGAGNNNCCNNATNCTNANGANAAACAACCTGAANCCNAGAA GGCTGNTGCTGGCAANAANGCTAAAAAGGTGNACANGGTAGAAGCAATGTTAAGAAGGG GAAGCCNCACTGCAGCCGAAATCCTGTCCTGGTCACAGGAATTGGCANATATTCCCGATC AACCATGTACTCCAGANNGGCCTTGNACAACATAANGTATTCANCNNCTAAATCCNGGGT

CAAAAAGAAAANGAANGTTCGNGTTCTTGCTACTGTCACAAANCCANTTGGAGGNGACN NNAATGGNGGTACCCCACTGGTCAAACTTCGNANAANGCCTAGGTATTACCCTACTNANN ATGTGCCTCGAAAACTGTTGAGTCATGGCNAAAAACCNTNCATTAAGCATGTNAGGAATC TGCGTGCCAGCATCACTCCTGGNACCATNCTGANCNTCCTTACTGGGCGCNANATANGCA AGAGGGTCGTNNTCCTGAACCGGCTGNGCAGTGGCTTGCTACTNGCGACTGGGCCTCTAT

CCCTTAATANAAGTTCCTCTGCGTAGAACACACCANANNTTTGGCATTGCCACCTCCCCCA ANATCGATNTCAGNGNTGTNAAAAATCCCAGAACATTTCACTTGACCCTTACTTTAAANA AAAAAAAACCTGCGNTGNACCCCNAANACCGGGGAGGGCGNAAATCTTGGNCCCCGAGG AGAGANATTTTCCACNTTCCCCGNNCCCCCNCCANGGGGGGATCNCAAAAAGCTGGGGAN CCCAANAAANTTTTGCGNAAAAAN(^AAAGGTGGCCCTTNNCTTTCANGGGGTTACCTTC

GGGTNCCGGTTTTGGCTTTC(^AAAAANGGANTTTNTNCCNCCCCNAAAAAAT^ NAAAACTTTTT

TTGANACNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCNGNNCGAGGCTCαSfNNTNCTTTGNTGNNNNAACCNGNNNCCNGGNN CGCNGNNGCTGNAGCNANTGCTAGAACAGCGGGGAAAGNGATNCTTCTCNTNAGCCAGA NGGTGCTGTGNNCCTCCTATGATCTGTGNAGAGGACTANGCGTATATNTCTANATTACAC ATGTGGNCTAAAGATGCCNTTACTNNNACATCCTTTTNTGGGCTNACTCCACCNNCCACTG

CGATAACCTANTTTCAGCCGNACCACACNGNCTNAAGCGNACCATGATNGNGACGTNACC NNTGGCACCCNTGNGNTNAAANNCAGAAAANGGOSINNGGCATTACTNNNTTGAAGAAGG CCNCCCAANANNGCTNAACCATNACACNNAACNNTTCNATACCNNNNTNTCGNATCTGTA TGANCCAATGANTGCTGGGNCCATGNTAGCTNTGNNGNCTGGGCGCAGGNNATGCCAGA GGANTGTTTTC(3NGGCACCCTTAαSICTCCTGNCTACTTNTTNNTNGCCCATCTNTCCCTTNA

ANCTNGCCCTCTGCGTTGAACCGCATGAAAAANTTNCCAATTTGTTGCAATNCCCTTANTT TTANTTCAGNNATGTTTTTGATTNCCCTAGCTTTCAGAACTGGACCCTTTNTTTAAA^ AGNAACTAAGNTNGNGATAGTTCNNTTTGNCCCCAGGGNGGGGGAAAAAATNTTTCTTNT TTOWGGGGTTAAAAATNTTCCCCTTGGAACCCCTTTTTTCAAAGGGAAAANGAT^^ NC^AANCCTTTGTTGGCAANAANAAAAAAANGGGCNAAAAAAAAAAAANAGGAGTNCCC

TNCATTTTCCGGGGTTTTAACATAAAACCCCCGTGNTTTGNCTTTTTAAAAAAAA^ NT GCCTATANGGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGGAGAAAGAGCTCGGGGAGTCGGAGCGCTCGGAGTTTGCCACTTATCGGTCATCCTT GGTGTCCGCAGCACTCTCTCCCTCTCTCTAGGGCGGCGACCTCCGGCGGCCGGAAAGTCAC CATGTCCATCCTGAAGGTCCACGCCAGAGAGATCTTTGACTCTCGTGGGAATCCCACCGTT GAGGTTGATCTCTTCACCGCGAAAGGTCTCTTCAGAGCTGCTGTGCCCAGTGGCGCTTCAA

CTGGAATCTATGAGGCCCTGGAGCTCCGGGACAATGATAAGACGCGCTACATGGGGAAAG GTGTCTCAAAGGCTGTTGAGCACATCAATAAAACTATTGCGCCTGCCCTGGTTAGCAAGA AGCTGAACGTCGTGGAGCAGGAGAAGATCGACAAGCTGATGATAGAGATGGATGGCACA GAAAATAAGTCCAAGTTTGGTGCGAACGCCATCCTGGGCGTGTCCCTGGCTGTCTGCAAG GCTGGTGCTGTGGAGAAGGGGGTGCCCCTCTACCGCCACATCGCCGACTTGGCTGGCAAT

GCTGAGGTCATCCTGCCAGTTCCGGCTTTCAATGTCATCAACGGTGGCTCTCATGCTGGCA ACAAGCTGGCCATGCAGGAGTTTATGATCCTTNCTGTTGGGGCCGAAAACTTCCGGGAGG CCATGCGCATCGGAGCAGAGGTTTACCACAACCTGAAGAATGTCATCAAGGAAGAAATAT GGGAAGGATGCCCCAACCGTGGGANATGAAGGCCGGCTTTGNCCCCAACATCCTGGAAA ACAAAAAAAGCCCCTGGAGCTTGCTGAANAANGGCCTTNGGCAANGGNTGGCTACCAGN

GAACAAGGTCNTNATTNGGCATGGACCTAACTTGCCCTTGAAATTCTACAGGGTCGGGCA AGTATGAACCTNGGACTTTAANTCCCCCATGAACCCCT

ANCNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGNTTTTTTCCNCANNAGCNCAGACTTTATTTAAGAAGTCCTTGAGATACAAAAGA NGACTAGGGCTAGGTCTACAGATNACAGAAGCTTAACCCCTGAGTGTAAGAAGCACTNTA CGGGTAAAAGCNGGTGGGAGCAGAGGACACAANGGTGGNTGGCTNGNTATTTACTGGCT TTANAAAGCAGAGAGCCCAGATCCCAGCTAGAACATCCCAGTACTGGNTATAGATTCTTT ACAAAGGTGTGATACCCTCCTCATGAGCTCTTCTTGAATGGATACTTCTTCCGAAAAATNA

TCATTGACNTCCAACACGAGCACTGGAATGTTCAGCAGACCTCAGAGTGGAGCGGGGNTG TCTTGTGGACAAGCCAGGCTTNGNGTNGACCATGAAGCTGNTNCAGATAGGCCAGCTCAA CTTNTNTCTCCTCTNGCCGGACα^CCGNTGTANTCTCTTTAANCAAACCAATGTTGCCTTC CACCGAGAGNCTTCGGGGGACCACGCCCCGCGTGTAAACCNCCTGGAAAGGGGGCACAC CCTCNANTAAAGCGCTGAACCATGAACCTTCGAAGGTGCGCACAGCAACCCTAANATAGA

GGCCGGNCATGGGGCCTNCTACCCACGAATTCACGC(^GGGGTGACTTTCCGTCGAAAAC ACTT CCGNCCCCGGAAANTTTGGNNTAAACCCTTCCGGGGGGGGGGCCCGGNNCCCCA ATTNNNCCCTTTAAGNNGGAGNNNNNNNNAAAANNNNNNlSπ^NNN^ NNNNNNNNXNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNMNNNNNNNNN^

NNNNNNNNNNNNINNNNNNNNNNNNNNNN^

GCCCTATCTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGAATCCCTGGGCAGGGGAACTAAGACCCCACCCCGCAAGCC

GCGTGGCAGGGCCAAAAACAACAAAAAAGAGTTGGTGGTAAGGGCGTGTGTCAGGTTGT TAGTGGGCTGCCAAGGCAGTACTCGCTGAACCAACAAATCCCACTGCTTTTTCCTCCTGTA ATCTTTCTTTTTAAAACTTTAATCAGAGAGAATTTACATACCTACAATTCACCAATTTAAAT TATACAATCCCGTGTAAAGTTCACAAGGNTGGTGTGATCTTANAATACTTTTTCATCACCC CAGACAGAAACCTTGTGCCCATTANCAGACACTCTCCACATCCCCCCAACCCCTNTAGCTT

TTGGCAACTGNTAATCACTTCCTGCCTCTGTGGATCTGCTTTGGAGATTTCATATAAATGG AATCATAGAACATGCGACCTTTTTGTGGCTGGCTTCTTCTTCCATTCAGCATAGTGTCTCCA AGATAAACCTCCAAGATAAGCTCAAATCAGCACTTAATCCCTCCTTATGGCCAAGTCGTTT TCCACTGTGTGAGTGTGCTACATCCACTCGTTCTTCATCCATCAGTTAGCATTTGGGTTGTN TCCACTTTCTTGGGTCTTATGAATAGGGGTNATTACCATTCAGCCACAATTTTTTGTATAGG

GNGTTATATTΓTTCAAGNTCCTCTTGGGGTATACATACCCTAGGNAGNGGAGAATTNGCCC GGNTTNTATAAAGNCCAGNGGTTTAAACTNTTCCANGGGANGCTGGCCCAAAACAACTTT

TTTCCANNTGGGCAAGTGGCCGGTTTTNNCATTCCCCCCACCAANNGGNGGGGGTGGGGG

GTTΓTAAGTTTTTTTTCCGNNACNCCTTTANCCTNGTNCCTT^

AAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GTTTΓTTTCCCAAAAGCACAGACTTTATTTAAGAAGTCCTTGAAATACAAAANAANACTAG GGCTAGGTCTACANATANCAAAANCTNANCCCNTGAGNGTNAAANCNNTNTAGGGGTAA AANCAGGNGGNANCAAAGNACAAAANGGGGGGGGGNTGGGANTTTNNNGGNTTNAAAA NGNNAAAAANCCCAAATCCNANNTAAACCNTCCCANCNNGGTTTAAATCTTTTACAANGG GGTTCCCNTCCTCANAGACCTCTTCTGTGTGTGGACCTTCTTCCGAAAAATTATTTTNACAT CCAACACAGAGCTGTGGATGTGTNCACCAGANCCTCAGAGNGGNGNGGNGTTGTNTTGNN

CNTCTTNTGCGGNCCCCTGCTGTGTCTCTTTTTACACACCCCAGTGTTCTTTTCGGAGAAAC CTTTGGGCCACCCCCCCCCGCGTGTACACCCGTGGNNGGGGGCACACCCTAGAATNAGCN GCNGCACCATGAACTTAGGGGGGGCGCGCAACCCCTTAAAAAAGNGGCCGNCAGGGGTC NTTCCCNJNCCAANATTNCCGCGANGAATTCTTTCGNNNAAGAGCTCTTNCCCCCCNTNATG CTGGNGAAANAACNCTGCGGGGGGGCCCCCCCCCCACNNNNNCNNCTTTTANGGGGNNN

NNAAAAANNNNNNNΓ>ΠSINNNNNNNNNNN^

NNNNNNNNTSINNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNN

AAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GTTTTTTTCCCAAAAGCACAGACTTTATTTAAGAAGTCCTTGAAATACAAAANAANACTAG GGCTAGGTCTACANATANCAAAANCTNANCCCNTGAGNGTNAAANCNNTNTAGGGGTAA AANCAGGNGGNANCAAAGNACAAAANGGGGGGGGGNTGGGANTTT ϊNNGGNTTNAAAA NGNNAAAAANCCCAAATCCNANNTAAΛCCNTCCCANCNNGGTTTAAATCTTTTACAANGG

GGTTCCαsϊTCCTCANAGACCTCTTCTGTGTGTGGACCTTCTTCCGAAAAATTATTTTNACAT CCAACACAGAGCTGTGGATGTGTNCACCAGANCCTCAGAGNGGNGNGGNGTTGTNTTGNN CACANNCCNNNNTTNGTGNANACNANNANNNTNCN^ αsrTCTTNTGCGGNCCCCTGCTGTGTCTCTTTTTACACACCCCAGTGTTCTTTTCGGAGAAAC CTTTGGGCCACCCCCCCCCGCGTGTACACCCGTGGNNGGGGGCACACCCTAGAATNAGCN

GCNGCACCATGAACTTAGGGGGGGCGCGCAACCCCTTAAAAAAGNGGCCGNCAGGGGTC NTTCCCNNCCAANATTNCCGCGANGAATTCTTTCGNNNAAGAGCTCTTNCCCCCCNTNATG CTGGNGAAANAACNCTGCGGGGGGGCCCCCCCCCCACNNNNNCNNCTTTTANGGGGNNN NNAAAAANNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNN

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGGATAACTACACCCCAGCCAATCCACTCAACACACCCCC TCACATCAAACCCGAGTGATACTTCTTATTTGCATACGCAATCTTACGATCAATCCCCAAC AAACTAGGAGGAGTACTAGCCCTAGCCTTCTCTATCCTAATTCTTGCTCTAATCCCCCTAC TACACACCTCCAAACAACGAAGCATAATATTCCGACCACTCAGCCAATGCCTATTCTGAG CCCTAGTAGCAGACCTACTGACACTCACATGAATTGGAGGACAACCAGTCGAACACCCAT

ATATCACCATCGGACAACTAGCATCTGTCCTATACTTTCTCCTCATCCTAGTGCTAATACC AACGGCCGGCACAATCGAAAACAAATTACTAAAATGAAGACAGGTCTTTGTAGTACATCT AATATACTGGGCTTGTAAACCAGAGAAGGAGAACAACTAACCTTCCTAAGACTCAAGGAA GAAACTGNAAGTCTCACCATCAACCCCCAAGGTTGAAGTTCTATTTTAACTANTTCCCTGG AACCCTATTTAATATAGTTCCATAAATNCAAAGAGGCCTTATCAGGTATTTAAATTTATCA

AAAATNCCAATAACCTCAACACAAAAATTTGCCNCCCTAACCCAAATNTTACAAACCNCC CCTTAGCTTAACATTAACCCGCCCCNTTCCCCGGACCCCAGGAATGGANTTNCCTACGCCA GGGGGNAATGGGCCATAACCATTAATGGGAATNAAGGACCTTAATATGNGTTTTAGNNCC NTTAAAATTNTI GGCCCCCTGGCCTATTAAGCCAGGTNCCTTGGACCTTTTTTAGCCGGN CCCTAAATACCTTTΓAAATTNTTGGGCCGGGGCNTTAGNNCCCTTNTGGGCNAAAATNATN

TTNTTGGAAAG

ANNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGAATTCGGCACGAGGCTCTTGNTGGGCAGCCTTGGCTTCTGTCATCGTCGTGCCTCCGC

CGCTGTCGCCCCCGCAAGGCTTTGCCGTCGCCGGAGCCACCTCCAGCGACTCGTCGCACCC

GATTCTCTCCGCTTCGCTTCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTATTCGAG

TGACCGAGACCGTGGCCGGGATCGAGGGTTTGGTGCTCCTCGATTTGGAGGTAGTAGGGC AGGGCCCTTATCTGGAAAGAAGTTTGGAAATCCTGGAGAGAAACTGGTTAAAAAGAAGTG GAATCTTGATGAGCTGCCTAAGTTTGAGAAGAATTTTTATCAAGAACACCCCGATTTGGCT AGGCGTACAGCACANGAGGTAGAGACATACAGAAGAAGCAAGGAAATTACAGTTAGAGG TCATAATTGCCCGAAGCCAGTCCTGAATTTTTATGAGGCAAACTTCCCTGCAAATGTCATG GACGTGATTGCAAGGCAAAACTTCACTGACCCACAGCTATTCAAAGCTCAAGGATGGCCA

GTTGCTCTAAGTGGGATTGGATATGGGTGGGGTAGCACAAACTGGATCTGGGAAAAACTT TGCTTATTTGCTGGCTGGCATTGGNCCCATTCAATCATNAANCCNTTCCTAAAAAAAAAGG GGATGGGNCCTATTTGCTTGGNGCTGGCNCCTAACTCGGGAACTGGGCCCAACAAGGTCC AG(^AGGGACTTGNTGAATACTTGGAAAAACATTGTCNCTTTGGAAATCNACNTTGCANT TTTTGGGNGGGGCTTNCCAANGGGACCNCCAAATCCTGGATTTGGGAAAAAAGGNGGGG

GAAATNTTTNTTTGGAAt-MSfCCTGGGAANAACTGGTTTAANTT

TNNANCACAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGGAAAAACACACCTGAAATCTTTTTGGAAACAGAAATTCATTTTAAATAGAT GGCACAGAGGTAGTCTAATGTCATGGGAAATGAGAAAAAAATATATACACATTAAAAAG CCTTCTGTCTTTTTGCCTTTTATATTC^ GTGCAGCAGTGACAAAGCAAAAATCAACTAAAAGACTTAGATTCTATTGAGATAGGCAGG CTCATCCTAATTCTCAAATACTTACTTATATGATAGTAATATTCTATGCTACAACTATAAA

GAAAATACTACTAGGACACCCTCCACTTTCTTGAACGTATCAGAGTTTAGACAGAAGTAA GAGATAAACATCTATTTCTGCTTTATTGACTACGCCAAAGCCTTTGACTATGTGGATCACA ATAAACTGTGGAAAATTCTGAAAGAGATGGCAATACCAGACCACCTGATCTGCCTCTTGA GAAATCTGTATGCAGGTCAGGAAGCAACAGTTAGAACTGGACATGGAACAACAGACTGG TTCCAAATAGAAAAAGGAGTCCGTCAAGGCTGTATATTGNCACCCTGGTTATTTTAACTTA

TATGCNGAATACCNTCATTGAGAAACACTGGACTGGAAGAAACNCCAAGCTGGAATCAA GAATGGCCGGGAGGAAATATCAATTAACCCTCAGAATATGCNGGATGACACCCNCCCTTT TGGGCAGAAAGGGGAAGAAGGATCTTAAAAAGGCCTNTTTGATGAAAGGTGNAAANAAG GGAAGTGGAAAAAAGTTGGGCTTTAAAGCTTCACCNGGNTTGNAAAACCGAAAAATCATT GGNCTTNCCCTTCNCTTTNNTNGGGNAAAAAAAAANGGGGGNAAAAAGNGGGNAAACAN

GGTTαWAANTTTT

ANCANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGTTTTTTTTTTTTTTT^

ANAAGNCTNATTTAAAAAACNTCAGCCCNTNAANCCNTGTAAAAANAAGTNTNCAAAAN GTNNGNAAAANAAANCNTNCTTNAANCNTGTTNAAGNAAAAAANTTNTNNNA^ NATTTNNAGCOWTTNNTTNTTNGCNTTATNANNCANGGGCANCCAAANAANC TNNGNGGGGGAAACC(^CCNAAANCCGGTTTNGTNGNAAATCCCANCTTNNATNTNATNT TNNGCNATCGNCCNTTAAAAGNTTTαstTTTAGGGTAAANANGGNNGNANAAAGGGCNTTT

TAAAGTCCCAAATNTTNNTTNTNTTTTTTNNNANGNAANGTNTNCON^ TNCCNNTNGGNGGGGNTTTCCNGGCAAAGAAANCNCCAAANGGNTNTGNCNGAAAAAAA TANGGCCGCCCGNCNCNATGTTNTNTNGGGCGGGCGTCNTTGGCCTTTNGGGGNGGACCG NGCCCCCCGAAANGGATCCAAGTTCNAAAAATGGGAACTTTGNAAAAAATTACCCCGGCN ACTAAANTCAATCAAAACCCTCCCAAAAAATTCCCCNNTNTTTTAAAAAANGGNNNCCCC αsπSICNAAAANNCCCCCCCGNCCTGGANAANANAACCTNAAANCCCCCCCCCANATGTTTT GGGGAGGGGGGGCCCCTTGGCTTTTTTTTANAAAAAAGGNGTTAAATTTTAAAAACCCCC CGGAAAAAANAAAAAAAAAACCCCCCCCTTCTNNNGGGGGGGGGCCNCCCAACCCANNG GGGCCTTTNGGGGGGGCCTTTTNNCCNCNCCCNGGGGGGGGGAAAA

ANAAGNCTNATTTAAAAAACNTCAGCCΣ^TNAANCCNTGTAAAAANAAGTNTNCAAAAN GTNNGNAAAANAAANCNTNCTTNAANOSΓΓGTTNAAGNAAAAAΛNTTNTNNNAAAT^^

NATTTNNAGCOSINTTNNTTNTTNGCNTTATNANNCANGGGCANCCAAANAANC^ TISINGNGGGGGAAACCRØCC AANCCGGTTTNGTNGN^

TNNG⁽^ATCGNCCNTTAAAAGNTTTCNITTAGGGTAAANANGGNNGNANAAAGGGCNT^ TAAAGTCCCAAATNTTNNTTNTNTTTTTTNNNANGNAANGTNTNC TNCαSπSITNGGNGGGGNTTTCα^GGCAAAGAAANCNCCAAANGGNTNTGNCNGAAAAAAA TANGGCCGCCCGNCNCNATGTTNTNTNGGGCGGGCGTCNTTGGCCTTTNGGGGNGGACCG NGCCCCCCGAAANGGATCCAAGTTCNAAAAATGGGAACTTTGNAAAAAATTACCCCGGCN ACTAAANTCAATCAAAACCCTCCCAAAAAATTCCCCHNTNTTTTAAAAAANGGNNNCCCC OSIN(^AAAANNCCCCCCCGNCCTGGANAANANAACCTNAAANCCCCCCCCCANATGTTTT

GGGGAGGGGGGGCCCCTTGGCTTTTTTTTANAAAAAAGGNGTTAAATTTTAAAAACCCCC CGGAAAAAANAAAAAAAAAACCCCCCCCTTCTNNNGGGGGGGGGCCNCCCAACCCANNG GGGCCTTTNGGGGGGGCCTTTTNNCCNCNCCCNGGGGGGGGGAAAA

NCANNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTCTTTAAACCCTGCGTGGCAATCCCTGACGCACCGCCGTGATGCCCAGGGAAGA CAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCATCCAACTTCTGGATGATTATCCA AAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAAGCAGATGCAGCAGATCCGCATG

TCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAACACGATGATGCGCAAGGCCATC CGAGGGCATCTGGAAAACAACCCGGCTCTGGAGAAACTGTTGCCTCACATCCGGGGGAAT GTGGGCTTCGTGTTCACCAAGGAGGACCTCACTGAGATCAGGGACATGCTGCTGGCCAAC AAGGTGCCAGCTGCCGCCCGTGCTGGTGCCATAGCGCCGTGTGAAGTCACTGTGCCAGCA CAGAACACTGGTCTGGGGCCCGAGAAGACCTCCTTCTTCCAGGCTTTAGGCATCACCACG

AAGATCTCCAGGGGCACAATTGAAATCCTGAGTGATGTGCAGCTGATTAAGACAGGAGAC AAAGTAGGCGCCAGCGAAGCCACGCTGCTGAACATGCTGAACATCTCCCCCTTCTCCTTCG GGCTGGTCATCCAGCAGGTGTTTGACAATGGCAGCATCTACAACCCCTGAAGTGCTTGAC ATCACAGAAGGAAACTTTTGCATTCCCGCTTNCTGGANGGCGTCCCGCAATGTTGGCCAG CGTGTGCCTTGCANATTGGTTACCCAACCCGTNGCATTTGTACCCCCATTCTATCATTNAT

GGGTACCAAAGCGCGTNCTNGGCTTTTGTCTGNGGANAATGATTACACCCTTNCCACNTTG TTGNAAAGGNCAANGGCCTTNTTNGCTGGATCCATTTTGCCTTTTGGGGTTGGTGGCCCTG GNGNTTGTTGNCCCCNGTTGTTGCCCTTGTGGCCACCNCT

NCANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAANTTCGGCACGAGGGCCCAGCGAGCGCGTCTCCCAGGAGCAGTTCACAGCGTCCA TGTCCCACCTGTTGAAAGGAACTGCCGAGGAGAAGAGTCTCGTGATCCTGAACATGATTT CTGCCTCAGGAGGTCCCGTGAAAGCAAGAGATGTCCACAAGTTTACAGAGGACTTGGTTG

GCTCTGTGGTGCACGTGCTAAGCTACAGACGGCAGCTGCGAGCTGGAGTCANAAAGCCAC CCCCAGGCTCCCCATCCAGGGTGCAGGTGCTGGCTGCCCAGCTTGTGCTCCGAAGATGAA GGCTTAAGGTGGGCGGGAAAGCTTTCTGGGACCTCAGTGGTTGGACCGCGACTTGTGACC AGGCCCGTGCTCGAGGACTGGGGTGTTCCGGGGCTCACCACGTGCCACGTTTCTGAGCCT GGGTCATTCCACCAGGGCTTCCTCCTCTTGCGCTCGTCCCTCAAGCTGCCACCCTGGTCCC

CCGAGCGCCAGGTGGACCCGCAGCGGGGAGTTCGCCAGCGTCTGGACGTNCTTGTCCGTC ATCTACGTAACTCGCACCTTGCCCAAGAACCGGGGGCTNAACTTGCGCCCTACTTCTTCGC CACCGAACTTCCACGGGAACAAGCTTITGCCAACTTNTGCGGGCGCCATTCGCACACGGG GGGCCCTTGCCTGGTGCTTGNTCGAAGGACANGNNACCGGCCACGTTGTTCGGAAGGTTT CNCCTTCCTTGCTTCCTNGGAAAGTCAANCCCTTAANTTTTTAAANGGGGAACNANNAGG

GGCTTTTCTTGTTTTTCGGTTTTCCCCCGNNATNGGCGTTTTCACCTTNGGNGG AANAAACACTTANTTTTNCCTTANAAAANGGGGNANNNAAANTTTCCCAAANGGTTTTGG GGATTNNGAAGAAAAC⁽^CNGTTTCTTITTGGNT^ A

NAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCTTAAACGAATACATTAACGGTGCTAAACACAGACATTTTAACCCAAGTCACGACA TTCTTAGCTGTAACTCAGCTCTCACGGCCTCTTGCTCACCCATGAATGGTCCCGTTTTCCTC TTGCCGCGTGCACCTCCACCCATTGTCTTGGTGGCACATGGGTGGAACACTTGATCTGCTC

GAGTCTGCCTTCAACACACATTGCATCTTCAGATTTTCTACTTTTCTGNTCAAAACTAATAT TCACCAAGTCAGACTTTGNGTTAATTTTATATCAGGGTATTGGCTGCCAGGGGGTCATCCC TAAGTGGCCTGAAGATGGACAAAGGGAAGTAACAGGCACGTGATGTTGGCAAGGATGCT TCTAGGGCTANAGGATCAGTGGTGGGANANAGCTGCANAATCCACCANCCAGAACTGCA GATAACGAATCTTATGGNCAGGGGCTGTGACTGANAGAAGGAAACTGAGGNTGTGTTCTG AAAGTACATAAACTCTCACATATACCCAGTTCTTNACCATCTCCCCTCCTNACTTTGCAGT GCCATTTCTTTTTGCATTAGGCAATTTGCTCAGACTTTCCAGAGCCATGGCCCCATCCGTTC TCTGGAATCCCCCACACCCTCTGAGANGTGGATCACCACGTCCTGCAGGGNCTGNTCCCCT CCAAACTACCTTTTANGAAGATGCACGGACAAGGGAGGCTGTTTTCANACCCNNCAAAAG

ACCNNAAATTCNAGAAGCGAGGAGCCNCAACGTGGGTAAAAACANAAAAAAANGGGCA GGGGGGNGAAAATNGGGTTTTCTTTTTGGGGGNTTTCN^ TGGGATNGGCTGGTNCCCCAAAAAAATNTTTTTAAGTCNC

NGCCTACTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGNG(^ANACAAGTTGGTAAAGATAGAGTTTTTAATACCCCACTGTGTGAACAAGGAA TCGTNGGATTNGGAATNGGAATCGCAGTCNCCGGGGCTNCNGCCNTANCAAAAATNCAGT TNGCAAATNATATTTNCCNTGNTTTNGATCAAATGGTAAANGAACCNGCCANGNNTCGNT NCCGGNCNGGGNACCTTTTTAATNGGGNAANCCTAACCATCCGGCCCCCTNGGGGCTGNG

TNGGCCACGGGGCTCTCTATCATTCCCAGAGTCCTGANNCTTTCTTTGCCCACTGCCCAGG AATCAGGGNGGGTGCNCCCAAANGCCNTTTCCNGGCCAGGGNACTTNTTTTATNNNGCAT AGANGATAAAANCTNTTGTATATTTTNNGANCCTAATANNCTTNACNGGGCANCAGNGGN GαsπSfGTNCNTGTAGANCCATACAANATCCCTNTTTCNCAATCTGAAGTCATCCAAGAGGG GAGTGATGNTCTCTAGGCGCCNGGGGCACTNANGTTCATGTGNTCCGAGAGGCGGCTGNC

ATGGNTCAANAAAATCGTGGGGTGTCTTGGGANGTCNTTTGNTCTGACGACTNTACCACC GNGGGANGAGCAACAGGCANNANGGNTGTNANNANAACNNGGACGACTGGTAATAANT NAGGAGCTTNCTTTGGACGGCGGTTTTTCCTNTAAAAACCNCCCACCGNTGAAGNAAGAA TTGTTCNTCAACCCTGGNAACCTNCTTAAAGGGGGGGNGGGGGGGNANAAAACCNCCNN TTCCNTTTTTTNTTNGACCGNTTTCCNTCCCAAAACNGNNGGGAATNNNTTT^

AAAAAAAANGANNNNNTTTNC

NGCCTACTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGNGCNANACAAGTTGGTAAAGATAGAGTTTTTAATACCCCACTGTGTGAACAAGGAA

TCGTNGGATTNGGAATNGGAATCGCAGTCNCCGGGGCTNCNGCCNTANCAAAAATNCAGT TNGCAAATNATATTTNCCNTGNTTTNGATCAAATGGTAAANGAACCNGCCANGNNTCGNT NCCGGNCNGGGNACCTTTTTAATNGGGNAANCCTAACCATCCGGCCCCCTNGGGGCTGNG TNGGCCACGGGGCTCTCTATCATTCCCAGAGTCCTGANNCTTTCTTTGCCCACTGCCCAGG AATCAGGGNGGGTGCNCCCAAANGCCNTTTCCNGGCCAGGGNACTTNTTTTATNNNGCAT

AGANGATAAAANCTNTTGTATATTTTNNGANCCTAATANNCTTNACNGGGCANCAGNGGN GCNNGTNCNTGTAGANCCATACAANATCCCTNTTTCNCAATCTGAAGTCATCCAAGAGGG GAGTGATGNTCTCTAGGCGCCNGGGGCACTNANGTTCATGTGNTCCGAGAGGCGGCTGNC ATGGNTCAANAAAATCGTGGGGTGTCTTGGGANGTCNTTTGNTCTGACGACTNTACCACC GNGGGANGAGCAACAGGCANNANGGNTGTNANNANAACNNGGACGACTGGTAATAANT

NAGGAGCTTNCTTTGGACGGCGGTTTTTCCTNTAAAAACCNCCCACCGNTGAAGNAAGAA TTGTTCNTCAACCCTGGNAACCTNCTTAAAGGGGGGGNGGGGGGGNANAAAACCNCCNN CCNTTTTTTNTTNGACCGNTTCCCNTC AAAAAAAANGANNNNNTTTNC

TTGGANACCNTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGACTTTNNGCTCCCAACNNATTCCNCTNNATNCTNGGG NTTCTATNCTATGCAAGAGATACCTTCNTANTTGNATACTCAATCNTACNATNAATNNCTA NCCCACTATGANNANTNNTAANNCTANCNTTCTNTATTTNTTANTATNGCTNTNAAGCCNN

TNAAATACNCACCTTAGGGNTTCATACGGAAACCATNANTNNACCCTTCCACTCANCNNG GGTGCCTAATNNATGATNCCACTAAGNTTGCAACATTNCACCCGACGCTCACATTNAANN TNNNNNGAα^WACCTNNTACGTNANACCCCNTNTAATCGNCGGNTTNGNCANAAGNAAA AANANNNGGTNTNNGTNTGTAANNG(^CTAATAOSINANNTNCTTCTTNNNTNN^ C(3NANCCTGNNTTNTCATNAANACNNAATTAGGGNGGCCANCGGCCCTTAATGGGTNCCT

NTTAATTANNTTNNTATNCGTNNNNCC(-^TATGAAAAGCGAGNTTTAACANT^ CCANAAAACCTTCCTGNANNNNTAANTGCT^^

AAANATMSfTNTCCOSrATATNANNTACCCTNGCCCACTTTTTTANTTTT^ ACTCGNNNGNNGCCTTNCNTAANATNTNAOSITTTTTTCGCGNTNNGNCCTNTNTCCNANA CNTTNACTTNNGNNNCTTNGN^

CCCGNNNGGNCATANCNCCNNAACCANNGNNTTNAANTCCCNCGNCCCCANGGNGCTTTT

ATN<^TNANAATTNANNGNNNCTCGGCCCCC^

ATCCCCCNGGNTATACNNNNANNNCN^

TTTCTGCTGGGGCAANTS[CTNCCTTTANTTCNNNAAKNTNCTTlTSfTTNCAT^

NAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGATTGANTGCNGNNTGAATNNAGCGGNNAACANGCTCGGGGCCANNNTNGCGANTAA GAACTGNNNNCGNATACANGAGNGNNTTTTTTIΗ^AAACTANNNCAC^GNTTGNTGGNTNA

CTGGCTGNN ACAANATATC(^ACCCTTNAACNNCTGTCCGANCTANCTGNANTTNAANG GATGGNNANNGGCAANNNCCCCTNGNGNANNGACTNTCNTCTAGGNGCANGGGTACAGG GGTNCTNTTOSRNACNCCTCNGCCNCNTAANCTGNNNNCANGCNANTGACCNCAGCNGGAC ACAGGGTNCATNTCCTGGGAAGNTCNNAACNGGTTACATCNCACTTGATGNTGACNTCNA AGACTTTTCCCTAGGAAGAACCAATGGGGCACNCTTTTACNTGGAGNTGCAATCCNGGGA

TCCGCANNCANNGTTTGACAAGGTAATTAATGCTCTGANTGAACGGGNCTNCTTCATGAT AACCCTCCAGTTTNGGACGGCTTGCCCGACCTGTTATGNGTNTGGGCCCNANGNGCTTGC ATGGNCAACCTTNAGGNGGCAAAAACAATCAAGTTCACCNCCTCATGGTNTAACCAAAAC AATGGCTTCCTTTAAGTGGNGGTAAAACCCCCTNNNTNNNNNNNTTTTTNCAANANA^ NGGGNNAAGGGTCCCCΑSTITWGGGGGGGGGGNAAAAAANGGNCNAAANNTTNAAACNN

ANCCCGGGNCTGGTTTCCTTNNAAANNNTTTNCTTTTTTTN GGGATTNCNNNNNAANNTTNNCCCNCNNNTTGGNCCNNNGNNNNGGNAAANTNNNTNAN NNNGGGNNNNNTNOSΓNNTN(^TTAANNNCCNNNNGGN WG

NAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGATTGANTGCNGNNTGAATNNAGCGGNNAACANGCTCGGGGCCANNNTNGCGANTAA GAACTGNNNNCGNATACANGAGNGNNTTTTTTTNAAACTANNNCACNGNTTGNTGGNTNA CTGGCTGNNNACAANATATC(^ACCCTTNAAΑSΠSTCTGTCCGANCTANCTGNANTTNAANG GATGGNNANNGGCAANNNCCCCTNGNGNANNGACTNTCNTCTAGGNGCANGGGTACAGG

GGTNCTNTTCNNAαsrCCTCNGCσsrαNrTAANCTGNNNNCANGCNANTGAC ACAGGGTNCATNTCCTGGGAAGNTCNNAACNGGTTACATCNCACTTGATGNTGACNTCNA AGACTTTTCCCTAGGAAGAACCAATGGGGCACNCTTTTACNTGGAGNTGCAATCCNGGGA TCCGCANNCANNGTTTGACAAGGTAATTAATGCTCTGANTGAACGGGNCTNCTTCATGAT AACCCTCCAGTTTNGGACGGCTTGCCCGACCTGTTATGNGTNTGGGCCCNANGNGCTTGC

ATGGNCAACCTTNAGGNGGCAAAAACAATCAAGTTCACCNCCTCATGGTNTAACCAAAAC AATGGCTTCCTTTAAGTGGNGGTAAAACCCCCTNNNTNNNNNNNTTTTTNCAANANAAAA NGGGNNAAGGGTCCCCCNTNNGGGGGGGGGGNAAAAAANGGNCNAAANNTTNAAACNN ANCCCGGGNCTGGTTTCCTTNNAAANNNTTTNCTTTTTTTNGGGCCANCNAA(^ GGGATTNCNNNNNAANNTTNNCCCNCNrWTTGG^

NNNGGGNNNNNTNCNNNTN(^TTAANNNCOSπsπSINGGNNNGGG

TTGAACAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCNGCACGAGGAGGACTACTAATATACCGANCCCACCTANTATCCTCCC

TTCTATGCTTAGAAGGAATAATGCTATCCCTATTCGNTATAGCAGCCCTAACAATNCTNAA CTCACATTNTACATTAGCTANCATAATACCTATTATCCTACTAGTCTNCGCAGCCTGTGAA GCAGCCCTAGGTCTATCTCTACTAGTAATAGTATCAAATACATATGGACTGATTATGTACA ANAACCTNAACTTACTNCAATGCTAAAATACATTATTNNAACAATTATACTTATACCCNTA ACCTGGNTATCAAAAAATAATATAATTTGGGTTAACTCCACAGCACACAGCCTTCTAATTA

GCTTTACAAGCCTNCTCCTCATAAACCAGTTTGGCGACAACAGCCTTAATTTTTCACTACT ATTTTTCTCCGANTCCCTATCCACTCCANTACTAATTTTAACCATATGGCTCCTCCCTCTAA TACTAATAGGCTAGCCAACATCATCTATCANAAGAAAACCTAACCCGAAAAAAACNATTT ATTACTATGCTGATCTCACTACAACTATTGCTAATTATAACCTTTACCGGGCATNGGAACT AATCTTATTTTATATCCTATGNGAAGCAACACTAGTCCCAACACTCANTATTATTACCCGA

NGAGGAAACCAAACCAGACGCCTAAACGCCGGACTCTATTTCCTATTCTATACCTAAGCN GGCTCCCTAACCCTATTAAGCGCNCTAAATTATATTNCNAAACCCGGGGGGANCCCTAAA ATTTCCTAAAAATTAACGGGNCNGGGGGNCAANCCGGGTCAAAAACCCTTGGAAANA NNNNATCTGGAGCTCCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCATCCTGGGCGGGGTCATTAGCGCCATTAGTGAGGCGGCTGC GCAGTACAACCCAGAGCCCGTGCCCCCTCGCACACATTACTCCAACATTGAGGCCAATGA GAGTGAGGAGGTCCGGCAGTTCCGGAGGCTTTTTGCCCAGCTGGCTGGAGATGACATGGA

GGTCAGCGCCACAGAACTCATGAACATTCTCAACAAAGTGGTGACCCGACATCCTGATCT GAAGACTGATGGCTTTGGCATTGACACATGTCGCAGCATGGTGGCTGTAATGGATAGTGA CACGACTGGCAAACTGGGCTTCGAAGAATTCAAGTACTTGTGGAACAACATCAAAAAGTG GCAGGCCGTATACAAACAGTTTGATGTTGACCGTTCAGGGACCATTGGCAGCAGTGAACT CCCAGGGGCCTTTGAGGCAGCAGGATTCCGCCTGAATGAACATCTCTACAACATGATCAT

CCGACGCTACTCAGATGAGGGAGGGAACATGGATTTTGACAATTTCATCAGCTGCCTGGT CAGACTGGATGCCATGTTCCGTGCCTTCAAATCTCTCGACAAAGATGGCACTGGACAAAT CCAGGTGAACATCCAGGAGTGGCTGCAGCTGACCATGTACTNCTGAACGGGAGCCCCAAG GCCTGCCCCCTCATCACCTTGCTGTANGAGTCACCTTGGACTTTTCGGTCTTCCCCAAGGG

CCCTTTGGCANCCTGGATTTCTCANTTCAACAAGCCANGGCCCCAACATGGCTTTAAACAC

GCCCTTGCCCCTTNAAGTTAACCCCCCCCCCAANANAACCCATTTTGGNTTACTTCCATTA

ACCCTTTTTTTTGCNCCTGGGCCAAACCCCAACATTTGGGTG

TCNTCAGNGGGNCNCGGGCGCAGCGCGCANCGTGCCCCNNACNNTCTNCATGNNATACNC

AACNNTGGNAACTGTCNTCCGNNNOSIGTTNATGNNCNCNCTTAANCANCNNNANGGCNA

CCNCTNCGCCTCNGCNCTNCCNNTT(_^ACNNNCNGCACAATATTTTNTNATNTNNTCCACC

CCNCNTNCCCNTCAAANNCNGNNNGGGGNNCCTTNNTGNCCTANNCNCNTTACCNAANCC NCTCNTNNNTANCTNCNGANNTATTANNCNTANAANANNGCGANNCGNCCNGGNGGNGG

TGTNCNTAGTANNNANNNATTGGTNNCAGNNNCCTNGNCNNGNNCTNTNTNNNNTNNTA NNTGNTGTNANNNNCGNNCGNNGNATANTNTTNNGNGNGNNGNNGGGNAGNGNGACNG GNTNTNTNTTGTTNNNTNTGNN<^ANGG NGTNNANNNTTNTATNTNTGTNGAANANACTANNGCNCTCCAGGGNTCGNNNTNTTCNTT NNNCN CNNGNGNNCANNCNNGGTAAGNNNCTNAGNNGNNANNNGCNNNGNNCCCNNC

CNATT^WTGGTNNTATTNNNGAGNGNCCNCNNGAGNNCNNNNTNNGAGNNATGATCNCN CAANNNNTNGTCCAGGCGNANAANANGNNNTANATCGNGANNGNNCNCTGNNGNNNGG ANNNNATNGACNGCNNNNCTNGGNANNGNNCCNN^ ANNTCNNGNGCTGNNGGGCNGCNGTCTNNNANNGNTANTGNGGCGNNCGCNCNCANNCC ACCTGTAGTCATNTCATCGNANNTNCCTCCACGNACGAGCGNCCCCCTNGNACGGTCNNN

TNCTCCTCCGCTNCCACCACaSFCACOSINNCCAACNNNCNATCNTAGTANNGTCCTCCNTCC NCNANCCCTCAANGATCTTNCNNTNTTTANCCCACNGGATNCTNTGCCNGNCCGTCGCCT NGCGNNTNCANNNGNGCCTAANNCCNNCNCNTTCNGNCGGGCGGCTCNGACGGAGTTGN NTNNTCACTTCACCATO πSfCTNCAGNACTNNCGNNGCNGTNNTATANAANANCAGCNNCA NNANTAGGGTANNAGTTNGGANGNGCANTNNNGGTGTATATGOSfANGGCNNCGGTCANC

NCGNTAANANGNNGCGANTAGTCCAGANAGGNAGCAGATANANCGNCGCANNCNGCGTT GCGNNNNTATANNNTWTGCNANCNANNNα TSINNNCNNCGTGCAGCACNTGCATNC(^ NANANANTGTNANTNTGCGAAAGCGANANANTANCTAACGAGANACTTNCCCNANATAN AGTGNTATANAGNNNNNNTGATGNNACTNTGTCTTGNNANNGNGAGCCG

GGGGGGGGGAGCAGANTAOSRTANNATAATTTMTNTNTNNATNNNNNNNTCAAC^

ACACTCNANNCTNANTAGANCCGACNAAANACNNTCNNTAGNNGGGGGGAATANAGGAC

GANATATGATTNNTTTTGGAGANAOSΠSΠSΓTGGANNTNCATNNCNGTGGCNGGCCGCTCTAG NAACTAGTGGANCCCTTCGGNCNTGNNGGNGNANAGAAGANNCATNGTTTTATANANTA

GCTNCTTANNNCANNNANTGCNAGCGGGGGTNNTNATTTNTTTTTNT^ NNCANTNNCANGTNTTCGTTNCTNGTGANTAGCAANNACTATNTANAACTNTNTTANTAA NTNATATCTTNCNCTTGNTATTGANGTAANANTGNTNANTGANAGCATNNGAAGTTNNTN CNGCANCTTGGNATTAGGANGACCNTTNTCNAATTTNGNNGNAANCCNNCACGNATTCNT GNTTNTNTTTGNGGNGGNNTGTNNTCGNNTCANNTCTGCTNTNTATNCATTNCNCAAGAN

TNCLSFNGAANACTTTTATTTGNNCACTGGN(^AAGNATNATAGGNGGGTTGGTAANNATAN NANNTCACNTNTTTTGATNNGCCAAANNCGANCTTTANTNNATTATTCACTNTCATNAANC ATNGAATANAAANAANGGCNNTGATNANANTNGTTNTTTGAANCCCNTAANAACTGACTT TGATANNANTCNTTNNATSFNNATNGNCGAGA AGAANNACANNNGACCNCNCNCCTTGNNNCCCAANGCNTGANANNTAATNTNTCATATN TATGGGNGANNATAGAATGGCTCANCACNAATATACNTATACNNTCNAANGACGCATNC ATNTGGGCTTNACANNNNTNTAAG(^CCNAANNCGTGNACTATTATTTGTANTTTGGGA^ NNNACTACANANATCCACTTTlSINNAαSITCTNATATTTTNNTTAATAGNGCTO^ GATTCTTGGCTGCGGANNTTAATANTCTAATCCCTTTTGAGGAANGTNGNGCACTTGCACN

NATNNATGCTACAGGTANTM TTGNAGNNAATAANATATNACATGTNCATTNNACTTTGCC NNCACCNATTNATCNATGATANANATTATNNTNTACNTGTTGGGNAANTNNNTCTCNTCN αsINANTCTGNANCTATTCNTNTANTTNCANTAGANTTTGTAATAGTANATTCTNCTATACT TCGNTCTTNNATTANTCTGTGNCANNCC(^CCTTGANTNCCNTNANNNNTAGTGGTNGCGT CTAN JNNTCGTCTNTACTN<^AG(^CCGTCNCAATGNANNATNNANTNTATCATNTNTTG

TACGNAANNCGGTTCAATCCATTNTATGNATATTATNTAANNNAAGGAGNACTNATATCA TCNCGGTTANTATGAAACNACCNTNTGTGATGGAANGAATNANNNTCATGTGTTTTCTAN ACTCCGN

GGGGGGGGAGCAGANTACNTANATAATTTTNTNTNTNNATNNNNNNCTCAACNNTN^

ACTNGATNCTCANCNANNNCCGACNAAANNCNNTCNNTANNGNGGGGATANAGGANGAC

NTATGATTCNTTTTGGAGANANCNNTGGAGNTNCANNCNGTGGCNGGCCGCTCTAGNAAC TAGTGGGANCCCTTCGGNCNTGNNGGNGNAAANAAGAGNNATNGTTTTNTATANTAGCTN

CTTANNNCAINNNNTGTNCCAGCGGGGNTNNTCANT^ NCCACNNCCANGTNTTCGTNC^CTAG ANTAG

ATATCTTTOSICTTGNTNTTGANNTANANTG(^TNNTGANAGCATNNGAAGTTNTNCGNNN NCTTGGNATTAGGGAGACCNTTNTAAATTNTGGAAACNTNACGATTNGNTNNNNTNGNGG CTTGTNNTCGNNTCANNTCTGCTNTNTATNCATTNCNNAGANTNCCTGAANACTTTTT^

AANCCTGGT(^AAGNACTNATAGGNGGGTTGGTAACNCAAGANANCACCTNTTTNGATNN GCTCAAANNCGANCTTTANTNNATTATTCACTNNCATNAANCATNGANTATAATANAATG GCTTTGTTATANTNNTTTTTTNAANCCCCTAATAACTGACTTTGATANCANTCNTTNNAN^ CTNNACGAGAATNCAAGTGNNNTNNTTNGTTNTNGNNANAATNACANNNGACCNOSrCNC CTTTNNNCNNAANGCCTGNTTTNTATTNTNTCATNTGNTATGNGNGNNNATAGAATGGCT

CANCACTANTATACTNTTACNNTCNAANNACGNTNCNTNTAGNGCTTTACANTNNTNTAA NNTAC(^AANNGTGTA(^ATTATNTNANTNNTGGGCNNNNCACTNNNANACATCTCACTT TNNNNTTACTNATATTTTTNCNNATAGAACTATGTNCTNNGATTCTTNNNC^GCGGA ANTANTCTAATCCCTTTTGTGNAATGTANTNCANTAACAG fNNrTNNAGCTCANNGGGTA NTCNGNAGNNAATAANNTATNNTNATGTNCNANTNNACTTTGCCCTCACCTATTTACTNN

ATGATANANNATTATNCTGTATNTGNTNGNNAANTNNNNTNTCNCNCNCANTNTNCANNN ATTTCNNNTAATANOSINTAGNNNTTTGTAATAGTANATTαWCTATACTTCTCTCNTNNAT TATCCATNTGNGNAANGCCCTCCTANNATTNNCNTNANN(^TAGCGNTNGNNTCTNNNNN TTGATCTCNTACTNNNNNGCNCCGNCNTAANGCANNGATNNANTNTATCATNTNTNGTAC GNACANGCGGTT<^TANCCACTTGTTGNATNTTATNTAACTAAANGACTNACTNATATCAT

NNC INNTAAATATGAAGCGACCCTNTGTNATNGNAGA TNANNNTCATGGTGTTTTCTAN ANTCCGG

TTNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGCTTTGCTGAGGGTCACATTGAGCTCCCAGCGACTTCAGGGGCATCTTTAGGAGT CAGCACTATGGCAGAAGACATCCAGGCCAAAATCAAGAACTACCAGACTGCTCCTTTTGA CAGCCGCTTCCCCAACCAGAACCAGACCAGGAACTGCTGGCAGAACTACCTGGACTTCCA CCGCTGTGAGAAGGCAATGACCGCTAAAGGAGGTGATGTCTCCGTGTGTGAATGGTACCG GCGTGTGTACAAGTCCCTCTGCCCCATATCCTGGGTGTCAACTTGGGACGATCGCCGGGCA

GAAGGCACGTTTCCTGGNAAGATCTGAACTGGCTCCATCCCACCTCTTCTGTCCTCCGTCC TTCTCCCAAGGGTGGTGAAGGGGGACCGGGTACATGGTGATCCCCACCTTGGAATCCTGA CTCATGGTATAACTAATAATAAATGCTCGTTGGAAACGTGAAAAAAAAAAAAAAAAAAA CCTNGGGGGGGGGCCCGGANCCAATTTNCC(^TATNGGGGGGNNNNNAAAANNNNNNNN NNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNTSπSINNNNNNNNNNN^ NNNNTSπSINNNNNNNNNNNNNNNNNNT^^ NNNNNNNNNNNNKN NNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNN

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTGCA

GGACAAAGTGGCTTCAGAANCCCTCATGAAGNACCACATTCTAAACACCCTCCAGTGTTC TGAGGCTATCATGGGAGGAGCAGTCTTTGAGACTCTGGAAGGAAACACCATTGAGATAGG ATGTGATGGTGACAGCATAACAGTAAATGGAATCAAAATGGTGAACAAAAAAGATATTGT GACAAATAACGGTGTCATCCATTTGATTGATCAGGTCCTGGTTCCTGATTCTGCCAAACAA GTTATTGAGCTGGCTGGAAATCAGCAAACCACTTTCACAGACCTTGTGGCCCAGTTAGGCT

TGGCATCTGCTCTGAGGCCAGATGGAGAATACACTTTGCTGGCACCTGTGAATAACGCATT TTCTGATGATACACTGAGCATGGATCAGCGCCTTCTTAAATTAATTCTCCAGAATCATATA TTGAAAGTAAAAATTGGCCTTAATGAACTTTACAATGGACAAAACCTTGANACCATTGGA AGGCAAACAGCTCAGAGTCTTCGNGTNCCGCACAGNTGCTGGCATTGAAAATTCATGCNT GGGNGANAGGAACCAGCAAGGAAAAATNGNGCCATCCATTATTCCAAGAAATCNTCAAN

CCACCANAAAAATCCCNTTTTTGNAAAACTGGAACCAANANAACCNCTTCAACCANTTTT NCCTAAGTCTACTTGNAACCTGGCAAACTTGNAAANAACCTCCTAACCCAGCCCTGGGAA ATTGGGACCTTTTTTTTGGNNCCAANCCAATGGATGCCCTTTTANGGGGAATGGGCCTAAT GGAAANAAAANGGGAAATTNTTGGATTTCGGGNNANAAAAATNGCTTT1TNAAAAANAT TTTTTCNTTTNTTAACCCGGAACC(-MSIGGGAGTTTTTATTTGGG

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCTTTGTAACCCTCCAACAATGAATACTTCAACTTGTATCAAAACAAATAATG AGTATCCACAATTCTAAAGGACAAACATGAACATTAATATTAATATCTCTGATCCTATTTA

TTGGATCAACAAACCTACTAGGCCTATTACCCCATTCATTCACACCAACAACACAACTATC AATAAACCTAGGCATAGCCATCCCCCTGTGAGCAGGAGCCGTAATTACAGGATTCCGCAA TAAAACTAANGCATCACTTGCCCATTTCTTACCACAAGGAACACCCACTCCACTAATCCCA ATACTAGTAATTATTGAAACTATCAGCCTTTTTATTCAACCTATAGCCCTCGCCGTGCGGT NAACAGNTAACATNACTGCAGGACACCTATTAATTCACCTAANNGGAGGAGCTACACTTG

CNCTAATANGCNTTAGCNCTACAACAGCTCTAATTACATTCACCATTCTAATCCTACTAAC AATTCTAGAGTTTGCAGGNGCTATAATCCAGGCCTATGTATTCACTCTCCTAGTCAGCCTA TATCTGCATGACANCGCATAATGACACCCCCAAACTCATGCTTATCATATAGGAAAACCC AAGCCCTTTGACCTNTTAAANGGGGCTTTGTCTGNCCTCTTAATAACATCCGGGCCTAAAC CATGGGGAATTCACTTTTAACTCAAAGGACCCTGGCTAATAAATGGGNCTAACCCCCAAA

TTTCCTTACCATNTTTCCCATGGGTGACGGAAATGTTTTCCGANAAAAGα^CCTTTCAANG GGGNCCCATAANCCCCACNTGTNCNAAAAAGGGGCNCCCGTTTTGGGAAAAAATTNTTTT TTTTTATTCCCCCGAAAAAATNTTTTTTT^^

TTNANAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCTTTGCTGANGGNNACATTGAGCTCCCAGCGACTTCAGGGGCATCTTTAGGAGTC AGCACTATGGNAGAAGACATCCAGGCCAAAATCAAGAACTACCAGACTGCTCCTTTTGAC AGCCGCTTCCCCAACCAGAACCAGACCAGGAACTGCTGGCAGAACTACCTGGACTTCCAC CGCTGTGAGAAGGCAATGACCGNTAAAGGAGGTGATGTCTCCGTGTGTGAATGGTACCGG

CGTGTGTACAAGTCCCTCTGCCCCATATCCTGGGTGTCAACTTGGGACGATCGCCGGGCAG AAGGCACGTTTCCTGGGAAGATCTGAACTGGCTCCATCCCACCTCTTCTGTCCTCCGTCCT TCTCCCCAGGGTGGTGAAGGGGGACCGGGGTACATGGTGATCCCCACCCTGGGATCCTGA CTCATGGTATAACTAATAATAANTGCTCGTTGNAAACGTGAAAAAAAAANAANAAAAATC TACNGGGGGGGGCCAGNCACCATANTCCCNTAAANGGAATCNGGAATNCCCNNTNGNNC

TTNNNTNTNAGTNNGNGGNTGNTNCT^^ CTCANNCNCCTTNTNTTTNTTTN^

NNGGNNTTNCCOSfANGNNNANNNGNNTTTTTNAAANT JNNNA^ GGGGGNTNANCM NNGGGNCCrøNNNNCNAATT]^^ NNNNNNNCCNNNAAAANNNC^

NNNNAAAAANGGGGNCCCNNNNTTAAAANNAANN^ NNAAA CCCNACTGGAGCTCCCCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGGATATATCCCCTCGTCAAATTCTGTAAACTAAAAGTCAATGTCGATTGAAGGAAAGGG AGTCAGAATTCATTCAGGGAAAATTTAAGTGATTACTTCAAACTCTTACTATTATTAAAAC TTTTTTATAAATAAATGCTTCTATTTGATTAACTATATATTCAGGGTAGAATTATAAATGA ATAATTCTGGCACAAAATAGGACTTCATAAATATTAGAAAAATAAATGAAATCATTGAGA

TGAAGATAAAATATAAGTCTTTATGATTACAATCTCTGTAAACATAAGTGAATGTGAGGA TTCATGTCTTAAATTCATCTCAACTGTGTAGAAAGCCACTTCCTTACCATGTTCCCATCTCT GTCCCTAAAGAATATCTGTGATTTTTTATCCAAGACTACTGTGCTCTCTCATTTGGTTGAAT GCCAAGCATCCACAGGCTGACTGTTGCTTCTGGACATCACTGATGCTACTTAGCAGCAGCA GCAGCAGAACACACCATAGCAGGTTCTGTTTCTTTTTTTTTTTTCCT^

ANCATTATGGAAATTOSΓITCCCTCTACCCNCTAAATTGGGGACAAAAACCTCNGTTTTTCC CATATNGCCNGANCTTTTCATTTTTATTCC^

ATCTTTAAAATCCNCCTTACATGCNGGCCTTTGGGGNNCCCCTTTNGAAGGGAAGGGAAT ANNGGGAATTAATTTTGGTNNTAAAAGAAAAGTNNATAAAANAATAAAGANGGNCAAAA TACCCCCCCCTGGTTTTTTGGANGGGNGGCTNCCTTTTTTTANAATCCTAACCGGGCNTTG

GCTNCC^AAAGGCGNTTNCCTANAAAATTTTTTCCCTTTNTGGTAAGGNCCTTT^ AAAATCCCCTCAAANAT

TNNNACAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGCNNTAGTNGAAGCTGGGGCANGAACAGGCTGAACCGTGTNCCCTCCCTTAGCA GGCANCCTACCCCATGCAGGAGCTNCAGNANATCTAACCATTTTCTCTTTNCACTTANCAG GAGTTΓCCTCAATTTTAGGAGCCATNANNTTCATTACAACANTTATCAACATANAGCCCCC NGCAATGTCACAATACCAAACCCCTNTGTNCGTATGATCCGNAATANNTACCGCCGTACT ACTACTACTCTNGCTCCCTGTATTANCAGCCGGCATCACANTGCTATTAACAGACCGGAAC

CTAAATACAACCTTCTTCGACCCGGCAGGAGGAGGAGACCCTATTCTATATCAACACTTAT TCTGATTCTTTGGACACCCCGAAGTCTATATTTTAATCTTACNTGGGGTTTGGAATAATCTC TCATATCGTGACCTACTACTCAGGAAAAAAAGAACCATTCGGATATATGGGAATAGTTNG GGCTATAATGTCAATCGGATTTCTAGGTTTATCGNATGAGCCCACCATATATTCACTGTCC GGAATAGACGTCGACACACGAACCCTACTTACATCAGGCCACTATAATTATTGCTATTNCC

AACCGGGGTAAANGTCTTCAGCTGAATGGCCACACTTCATGGANGNAATAATCAAATGGG GCTCCTGGTATAATGNGAAGCCCTAAGCTTTTATTTTCTTAATTTACCGGGANGGGGGTTT AACCTGGGAATTGNNTTAACCCACCTNTTTCCCTNNNANATTGGTNTTTACGAAACCATTA CTTACGTTGGNNGNACAATTTCCCCTTTTGTTTTAATCAAAAAGGAGCTGGTTTTTGC^ TTTATANGGGGGGGATTTGTTATTGGATTCCCCCNTTTTTNTAAGGGTTTAACCTTTCAAN

GNTTCCTGGAACCCAAAATCCCCTTTNNNAANTTTT

GATCTCAGAGGGGGNGGNTGCG(^CNTSfαWTAαWAACANACNGCGTNNTACTTNNNAC GCNNNCTATCNCNCANNTATNNCACNCGTANTACGTGCNCCNGCGTCACTCCGNACTGCN

NGGNACCNCCGCTNNTCCNATCAATTGATANNNTCCCTNCNNNTTTTNNCTCTCTTCTTCN TNTCCTACTNNACTNNTNANTGNNANNATGNANCNNGNCAGTGCTANCTANGCATCANCN NTTNGCAATCACCNNNAATCANATANGGTGTCTGCTNCTTNCANTCTNCHNNGTNGCCNN TCGCCGNTCCNCGACGCσWGCNNCCCAGNANCNTNCTATTCTAANNANNATANAGNNG GNGACNNAGACCGGGNCCGGNTNCNTNTNNNNNTATNNAAGATAANNNNATNGGCNNNN

GNTSINGNNTGTANNANTNAATACTNTNNCNA

CNNTGTGGGNNNGNNCACNTNGTANNNAANTGTNTNNNTNCNNATACTGGNNGGNCCNG AANTNNANTNANTNCNANNNNCNNGNGNNGG^ NGTGNGGNCGNGGNGANNTCNNGNNTANANGNGNGNGTTTNN(^TCNGAN^πSINNNTNGA NNTOSπSlNTNNNCGNTGCGNANNGNAAONlNTCNNATANNNNTGTNCπ^

NTTGANGNNGNNCGNGGCAANTNNAAAATCATNNANNGNNNANANGNCNGGANNGNNN TNANNNGANCCNGNNGAGATNNGGNACCAGCNTNAAANGNNTNANNAGTNNTAGANGN ANAGGNNNTCNTGAGANNGCTAANGGNAANCOWGNTNAGTNNGCANNANNC3SINCGAG ANCNTTNTATGTTTTTANNNGACANCANA^ AAT<^ATNGGGCCGCCATGTTNACCANNANANCCANNTCC

TTTAACTANNM^AATCNACTANGGGNTCTGCAAGC^ NC ACTGNAAGN<_ NAANONrCANT]NINANAGTO^

NCANAGNNNTCGNCTNAGCAGCANAANCNGTNGTACNTCACAGGANAACNCCAACGGGN ANCGTGGAACNNNNNNNACNANNNANTNACNANGTTCAGATCANNAGCGTANCNNNNNN GNCGNNTAGAOvINANAGAGTNα^CTGTNAATATACGNACNCNGNNCNGANANTANAANA NATGCTGNGNCCTGTGACNTNATNCACAGACNGANTACNCNCAAACNNAATNATATCGCN

NNCNNNAGANAGCATNAGNNANANNACGTNCAGTNAGAGAGANNANAGTGATAGNGCG CNANNGACCG

TTTNANCCTATCTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GCCTGCAGGGGAAGTGGGAGCGTTGTCTGATTCTGGCTTTAAACTCTCGTGCCAGTGCTTA

GGCTTTGGCAGGGGTOSITTTNAAANNCAATTNNTTTAANNGGGNCCTTGNCATNGNANNG ANNTNCANAATNGNAAAAANNGGGANTNGNNNGGNAAANANNGGCCAANNNNNNACNN

GNCCTNNNTTNGAAANNGNAAANGGAAANTNNAGNGGNNNNCNTATNNAGGCCNCTNCN TNTANCAANGGAAGAANTNNCCANTNGGAAAACCATGGGCGAAAGNATATATTTGGGCC CTTTGCTTCTGNGCATTCNTTTGGAGGCCACGCGGCTGTGCGCTGTGACACACTGTGCCNC ACACTGTGGCTCTNNACCNGGAAACAAAGGGCTACTGTGCCCTCTTANACAANCTGTTTTC CCAGATACCCNCTCAGAANACACACTCTTGTGTCCTGNCCCCNNNAGAGCGCTATGCCCTT

TGATGTNCACGCTNNCACAGAAAATACCNNGAGAGTTATTTCCCCαSfCAGAAAAAACCGT GGATCTCTGTGACGGGCATCCTACNTGGTGGNGTGGTGTTCAGACCNCCCCATNATNGGG TGCTTNTTTAΛTACCCTTTTTTTCTTGAGGGAACNTCTTCAGCTTCTTTCNTCAT(^TC ACTTTNTTCCAAACAATCATCCCTGGGNNGGGGTTTTTANAAATNTTTTTTT^ NNGCAAGCANGGGTNNTTTTTTTNTTTCT^^

TNTTGNAANGGGAGTCTTACC1TGCGNGNTTNGGNTTGGGGGGGCCATCCGGGAGGGAAA ATTCCTCCACCCAANAANAAAAAAAGGGNTITTGNANGGGAATTTTTTCCCCACC^TTT^ TTTNN

TTTNANCCTATCTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GCCTGCAGGGGAAGTGGGAGCGTTGTCTGATTCTGGCTTTAAACTCTCGTGCCAGTGCTTA GGCTTTGGCAGGGGTCNTTTNAAANNCAATTlSπSfTTTAANNGGGNCCTTGNCA ANNTNCANAATNGNAAAAANNGGGANTNGNNNGGNAAANANNGGCCAANNNNNNACNN GNCCTNNNTTNGAAANNGNAAANGGAAANTNNAGNGGNNNNCNTATNNAGGCCNCTNCN

TNTANCAANGGAAGAANTNNCCANTNGGAAAACCATGGGCGAAAGNATATATTTGGGCC CTTTGCTTCTGNGCATTCNTTTGGAGGCCACGCGGCTGTGCGCTGTGACACACTGTGCCNC ACACTGTGGCTCTNNACCNGGAAACAAAGGGCTACTGTGCCCTCTTANACAANCTGTTTTC CCAGATACCCNCTCAGAANACACACTCTTGTGTCCTGNCCCCNNNAGAGCGCTATGCCCTT TGATGTNCACGCTNNCACAGAAAATACCNNGAGAGTTATTTCCCCCNCAGAAAAAACCGT

GGATCTCTGTGACGGGCATCCTACNTGGTGGNGTGGTGTTCAGACCNCCCCATNATNGGG TGCTTNTTTAATACCCTTTTTTTCTT^^

ACTTTNTTCCAAACAATCATCCCTGGGNNGGGGTTTTTANAAATNTTTTTT^ NNGCAAGCANGGGTNNTTTTTTTNTTTCTAAAAAAATTCCTTGCCCCCNCAANTNATT^ TNTTGNAANGGGAGTCTTACCTTGCGNGNTTNGGNTTGGGGGGGCCATCCGGGAGGGAAA

ATTCCTCCACCCAANAANAAAAAAAGGGNTTTTGNANGGGAATTTTTTCCCCACCNTTTTT TTTNN

TTGANAANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGCTNTGCTGANGGTNACATTNAACTCCCNNCGANTTCAGNNNCATNTNTNGGN GTGANCNNTATGGNNCANNACATNCNGGCCAANATCAGGANCTACCANACTGNTCCTTTN GACNGNCGATTCCCCAACCNNAACCANACCANGAACTGCTGGCAGAACTACCTGGACTTC CACCGNTGTGACAATGATNTGACC(^TNNTGNCNGNAAANTTTCTGTNTGTGAAAGGNAN (^GCGNGTNTTNTNNTCCCTGTGGCCNNTAAAAAN^

ACANAAGGCACGTTTCCTGGGANGATCTGAACTGGCTCCATCCCACCTNTTNTGTCCTCCN TCCTTCTCCCCAGGGTGGTGAAGGGGGACCGGGGTACATGGTGATCCCNACCCTGGGATC CTGACNGATGGNATAACTAATACTAAATGCTCGANGGAAACGTGAAAAAAAAAAAAAAA AAATTTTTTTTNGGNNAANNAANGNNCGN^ AGGGTNGGNNNTTNNAAAAANNTTTTTTTTTTTT^

GTNANTTNGGTOWTTTTTN^CANCCCCC^ GTATNTmGGGGGTTTTAANGCC TTTNGCf^NNN^ GGGGGAATTTNNTTTTTTNNCCCCCNNTNA^ GNGGGGGGGGGNNCCCCCTNCTTNNNGNACANAAANNAACCNTTNANNCCNGGGGNNTT NNNNTNANAAAAANCGGGGGNTTTTTTNTGGAAAANTNNGGNGGGGGGNAAANNAAAA NTMjGGAAAAANAANAATTNTTTTGCCT

NAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGCGCTGCCCGGCCGGCCGCCCTGGCGAACGTGGCCGACACGAAACTGTACGACATCCT GGGCGTCCCGCCTGGAGCCAGCGAGAACGAGCTGAAGAAGGCATACAGAAAGTTAGCCA AAGAATACCATCCTGATAAGAATCCAAATGCTGGTGACAAATTCAAAGAAATAAGCTTTG CATATGAAGTACTATCAAATCCTGAGAAGCGCGAACTATATGACAGATATGGAGAACAAG GTCTTCGGNAAGGTAGCGGTGGAGGTGGTGGCATGGATGATATTTTCTCTCACATCTTTGG

TGGAGGATTATTTAGCTTTATGGGTAATCAGAGCAGAAGTCGAACCGGCAGAAGAAGAAG GAGAAGACTTGATGCCNTCCCCTCAAAGTTTCTTTANAAGACCTGGTNTATGGGCAAGAC ANCCAACCTACAGCTTAACCAGGAATGTNCTCTGGTATGGCTTCCANGGGCCAAGGGGGG NAGGCTNGGACCTGTCAAAAAGTGTAATNGCCTTGGTCGGGGGCCNAGGGGGNCNCATTA ATGAACAAAACAGCTGGCTTCCAGGGATGGNGCCACCAAATCCAGCTGNGGGGGTCTGG

ACTGGAATNGGANAAGGGAAAGGTAATTTATGGAAAAGGGNCCGTNGTAAAAAANGGGA NGGGAAAAAAAGGGGNTTAAAGAAAGTCCAANAATTNTTGAAGTCCCCCTTNAAACAAA GGCCTGNAACCTTGGGCCGGANAATTCCNTTTACTNGGGGAAACCAAACCNGGNCCCCCN GGGGNNGGNANCCCGGGANACATTGTTNTTTTTTGCTTCCANAAAAAAANAACCTTGGNG GGGTTTCCCANAAANACCGGGAATGGATTTGGCCCATTGACAATTTAAAAAAAAGGGACT

TGGTGGAAACCNTTTTT

TTNAANACAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGGTTTGCCGCCGGGACACAGGNGNCGTGAAAACCANN

GTTAAACCTAAGCCAAAATGGGAAAGGAGAAGACCCACATCAACATCGTTGTCATTGGGC ACGTAGATTCAGGGAAGTCTACCACGACTGGCCATCTGATCTATAAATGTGGCGGGATCG ACAAGAGAACAATTGAAAAGTTCGAGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTC AAATATGCCTGGGTCTTGGACAAACTTAAAGCTGAACGTGAGCGTGGTATCACCATTGAT ATCTCCCTGTGGAAATTTGAGACCAGCAAGTACTATGTTACCATCATTGATGCCCCAGGAC

ACANAGACTTCATCAAAAACATGATTACAGGCACATCCCAGGCTGACTGTGCTGTCCTGA TCGTTGCTGCTGGTGTTGGTGAATTNGAAGCCGGTATTCTCCAAGAACGGGCAGACCCGT GAGCATGCCCTTTTGGCTTACACCCTTGGGTGTGAAACAACTAATTGGGTGGGCGTTAACA AΛATGGATTCCACTGAGCCGCCCTATAGTGAGTCCGNTANAAANNNNTTTTGGNNNNNCC TTGTTGCCNCWGTTTTNNTTANAANGTNCNA^

CCAAAGNTTTNNGCCAAAACTGGTTTNAAACCCTNNTTTNATNCCCOSIN^ NAACCCOSπSfTGGTTTT JNNNCCCNNATNNGNAAαsrrα^ ACTACCCGTNTNNNNNNNNTNNTCNTNANNGNNNTNNTTNTNNNGNGGGGN^ NNNATTTTNCCCTTGNNGGC

TTGANAANACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCCCGTGTGGCCCTNTAGTGAGTNGNATTACATGCCGAGCTCCAGACAGACATCA ACGAGCTGACCAGCGACCTGGACCGCTCAGGAATCCCCTACCTGGACTATAGGACCTATG

CTATGCGAGTCCTGTTCCCGGGCATCGAGGACCATCCTGTCCTGCGTGAGCTGGAGGTGCA GGGCAACGGGCAGCAGCACGTGGAGAAGGCCCTGAAGCTCTTCGCGCAGCTCATCAACA ACAAGGTGTTCCTGCTGACCTTCATCCGCACCCTGGAGCTGCAGCGCAGCTTCTCCATGCG GGACCGCGGCAACGTGGCCTCGCTCATCATGACGGGCCTGCAGGGCCGCCTGGAGTACGC CACCGACGTCCTCAAGCAGCTGCTGTCTGACCTCATCGACAAGCACCTGGAGAACAAGAA

CCACCCCAAGCTGCTGCTCCGGAGGACAGAGTCTGTGGCAGAGAAGATGCTGACCAATTG GTTTGCCTTCTCCTGCACAAGTTCCTGAANGANTGTGCCGGGGAGCCGCTTGTTCATGCTG TACTGCGCCATCAAGCAAGCAAATGGAGAAGGGCCCATTGACGCCNTACGGGCGAAGCA CCCTATTCGCTGACGAGGAACAACTTATTCCGGGANCAAAATNGAACTACCAANAACCTT GATTTTGAACTGNGTTAAATCTTGACAANCAANAACAGCCCCGGAAATNCCAAGNGAANG

GNGT AAACTTGGGAACCCCNTCACCCCAGGTTCAAAGGANAAAAAATCCTTTGATGCA AGNNTAAAAAAAAACGTGGCCCCTTAATTTCCAAAGGGGGCCCAAGGGGNTTTGGGGAN ATTGGGACTTTNGGAANNGGGGGNAAAAANGG GCCTATANNGAGNCGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGTTTCTTTTCTCTTTTTCAGTAAAATGCAGTGATTATTTTTA TTTATGTTACTTAACTGTATATTATAGATATTCTTTCTCATAACTGCTTGGGCATCTAACTA GTACTTCTTTACAGAGGAAAAAAAAATTTCCTAAGGGCAGATCTACCATATTTCATTTACT

CATTCCTATGTTCACAGGAACTCACTTTGTGTGTGTGTATGTATTTTGGAGGACTGCTTTTG TΓTTGATCTTGTTGCTTTTGGTTTTTGTTTTGGCTGCCAAAAGTGATGGCACAAATATCT^ GAAGACTTTTTTCCCAAGATACCATATCCAAAAGAAACATAAAGCTTGACTGTCATTTTTC

AAAGCAGATAAGAGGCTTTTAAAGGATGAGTTTCCTGTGTGAGGACAAGATTCTGCCGTT TGACTGTTGTTGTTAAAGTCGGTAAGTCATGTCTGACTCTCTGTGACCCTGTGGACTGTTGT

TTGCCAGGCTCCTGTGTCCATGGCATTTCCCAGACAAGAATACTGGAGTGGGTTGCCATTT

CCTTCTCAAGCAATTTGATATGGTTCTTATTTTTATTCCAAAAGCTGAACGTGCTTTGCCGG GCCTGGTTAGTGAACATAGGACTGGAAACGCCCTCCTGGTTTTAAGAAATGCCTCTNGNC CAATCCAGTTGCCGCTAGCCACGNTTTCCTCTTTAATCTAAAGGTATNTAACNATTAGAAT AAAATTCCCGTTCANNTTCCTTTNGNNCCTTTNCCCCATATCAATAGGCTCCNTGGTGGTN

NNCGTGGTTTGAACTTTTAATTGCNTGGGCCCCTNGAAATGTNTTTTNANNNCAATTTTTT ATTATNACCCNGATGGGGGNNCNGGGGCTANCCCCCTTANANCCCCCGGTTCTTGAAANN TTTTCCCCTACTGGCAAAACGGCNTTTTGAACNCT

NNCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGGCCTGTACGCATGCGGGGAGGCTGCCTGCGCCTCGGTGCA TGGTGCCAACCGTCTGGGTGCAAACTCGCTCCTGGACCTGGTTGTCTTCGGCCGGGCGTGC GCCCTGAGCATCGCAGAGTCCTGCAGACCCGGAGATAAAGTTCCCTCGATTAAACCAAAT GCTGGGGAAGAATCTGTCATGAATCTTGACAAATTGAGATTTGCCAATGGAAGCATAAGA

ACATCGGAACTGCNACTCAACATGCAGAAGTCGATGCAGAGCCATGCCGCGGTGTTCCGT GTGGNGAGTGTGCTGCAGGAAGGCTGTGANAAGATCAGCAGCCTCTACGGAACCTGCGGC ATCTGAAGACGTTCGACAGGGGGAATGGTCTGGAACACTGACCTGGTGGAGACCCTGGAG CTTGCAAAACCTGATGCTTTTGTGCTCTGCANACCATCTACGGAGCCGGAGCCCCGGAAG GAGTCGCGCGGCGCCACCCCAGGGAGGACTTCAAGGAGAGGGTTGACGAATACNATTACT

CCAANCCATNCAGGGGCAACAAAAAAACCCNTTTGACACACTTGGAGGAACCCACGCTNT CTACGTGACATCAAAANTGGGAAGGGCACCCTGAGTCAAACCTGTATCGAAAAACTTTTA ACGAAAACTGATTGGNCCATGTTTCCCCAANCCTTCGNTTTTTAATGAGGANAAANGNGG TTTCCCTGGCCCNGGNAATAANNANAAAANCCCNCCCCCCCGGTTTAGGGNNNNNCCCCC NTTTTTTNATTGGGCCCTTNNNNAANNNGGGGGGGGCCTTTTNNNAAAAAAT^

NAAAAAAAAAA

TTCTCAAGGGNGGTGCGGANGCGAGCCTCACACGTCCCNNTNNACNCACCCNCTGGANNT

CTC(^TNACNTGCGGCNTGAACGCGANCCTCNTATNCNGTGTGCNCCCCCNAACNNGANA TANCAANNCCAGCCAOSINAGANNTTTCGCTATTCNTANANGGTNNCANTTANGNAACCCN TGGGGNNTTCCTNCATNGCTCAGNACNTTCTAAGTNNNNTNAAGCGCCNNANNTCNATGC

NCCACTTNGCCGNAACGNNAGNGNGGANCAAGANNGNNNCCNNANNNAACNGNGTTTGN NGCTN(^ANGANNNAAANGNNAATNTNTNNTNNNGGGNANTGGGNNCCNGGNGGGNNT

NNTNNTNNATNGNGNGTNNAAGNGGNCAGTNCAANTCTCANGNNNNNO ^'ATTGNNGGNN GNNNACGGCNANTNGCNTGNGNGNGTNGNAGNAGCGNNNNTGNTTCNCGNGNCGNCTAA TGCCCCTATGGGNNNNNNAOsπSTTNlSINNANNTNNANGGGGNCGGCCNGGCNGrø GAGATGNNNTGNGTTGGATNNGNNNNNACATNNTTNNTANNNNGGTNNNANANNGNGN^ NN⁽^CNNGNNGTNNTNTAT πNπN!N^^

NTNNNGCAGAGGNGACCGNNGNCAGNNTNNGTNTNTNNTNAANCCGGNCCCGAANNGCT AATGNGTGGNTCNANNANANTCAGNNNNNNNNGGNNGNATNNNNNAGGTNNGANNN^ NNGGNNGGGNNCANNATNCGGGGGGANTC(^TTNNNCTNTGGNGNTTAGNGGANNCCAN NGNACGTGNTNGN πWGACANNNNACCCNN(^αSfTTTGTAAGCTTCTCNANAAAGNTAG GGCGGCCAACC<^TCTCCCTCTNTCCTCTTCATNNAAGTCTTACCN(^ANGGCα^NNACCG

NGCCTNNTGCACTTNfNTGCNGNNNGCCTACGNGNCNGNTGCGGTACNGTGNTSfNTNNNTGC NNGGAANNCNlNNαsrCGTNCGTCCGNNANTACNNNNGCGGαSfCTNCNNAANT(^ CNCNCTGCNGCNGCACGNNNGNNGTGGTNCTGNACANAGTTNGCTNTGAGNAGTCNCNG NNCNNTNTNNACTNANTGNAGCGTAGCGGAGAGANCAGAANGGCANGTCGCCGCTGNNC NGTAGNNANNCTGNCANNGCCGGNTGNNTNTNTTGTCAACGNAGCGNNCNCCACAGTNG

NGANTGCNCTNGNGNGCGGCGNNGTNAGGNNAGNNAGTCGTNTGCNCNNNGNGANATCG

CGAANCNTNANANAGCCG

TTNAGCCTATNTGGAGNTNNANNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGNAGGAANTTCGGCACGAGGGCCACACCGAAGCCTACCCCAGCTTCCTGTCTGTGGA ACACTCGGGCCTGGGGCTGGNCCCTGCCTATGGGTNTTTACAAANCCCNTACGGAATNAC NTTCNANCCGCNG(^GCCANNAC(^AGGGCCNGαsrAGGNNCCAAANCCGGGGNANCNNA CCCGNNONriTNCCCNNANNNGNN<_^

NAANNTTCCGGTTTAAAACNNGACTTTTAGAAAGGGANNCCCACCCNGNAACNGGCTTGG AANTTTTACCNAACTTNACCAANTTTCCACTTTTNAACGGTTACGCGAACACAπ^ GCACANGGAAANNCCCATCCACNGGGAGAGTGTCCGGGTTATATCAAAACAGGGGGGAC ATNNAGAGAGTGNGAGCACCTTTTANNCTATANCACTGNGNTCTCTTTGCCCCAAANNCC NAGAGAGNGTGTGGCTTTGCNCGGGAAAAGANTGTGGANACCCANAAACCCCCGGGCGG

GGACTTTTNACANAGAGGTGTGAGTGNNCCCCCGANTANTGCACTGGNGGATAAAAAATA TATATNTCTTCTANTNTTACACCαsπsrCNTTTTGGACTACNCNCGAGGNCCCCGCNCCCTTC TCTTNTTTNNANGNGGTGGGGAGGGGNGGGGCCACAGGACTTCCTCCCCCGCTTGTGGAA GNCCCCAAACCCCGTTGNCCCCNGGGGCCGCNGNTTNTTTTNTTTTTTTTTT^ TCTTTTTCTTGNNGGGCCCCTTTTTTTTNCCCCCCCCCNGTTTT^

NNNNNAAANNGGGGGAAGGGGGAACCTTTT GGGAAAA AAA

TTNAGCCTATNTGGAGNTNNANNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGNAGGAANTTCGGCACGAGGGCCACACCGAAGCCTACCCCAGCTTCCTGTCTGTGGA ACACTCGGGCCTGGGGCTGGNCCCTGCCTATGGGTNTTTACAAANCCCNTACGGAATNAC NTTCNANCCGCNGCNGCCANNACCNAGGGCCNGCNAGGNNCCAAANCCGGGGNANCNNA CCCGNNCNTTNCCOSINAN^GNNCNNGNΠ^ NAANNTTCCGGTTTAAAACNNGACTTTTAGAAAGGGANNCCCACCCNGNAACNGGCTTGG

AANTTTTAC(^AACTTNACCAANTTTCCACTTTTNAACGGTTACGCGAACACATTCACANG GCACANGGAAANNCCCATCCACNGGGAGAGTGTCCGGGTTATATCAAAACAGGGGGGAC ATNNAGAGAGTGNGAGCACCTTTTANNCTATANCACTGNGNTCTCTTTGCCCCAAANNCC NAGAGAGNGTGTGGCTTTGCNCGGGAAAAGANTGTGGANACCCANAAACCCCCGGGCGG GGACTTTTNACANAGAGGTGTGAGTGNNCCCCCGANTANTGCACTGGNGGATAAAAAATA

TATATNTCTTCTANTNTTACACCCMN(^TTTTGGACTACNCNCGAGGNCCCCGCNCCCTTC TCTTNΓTTNNANGNGGTGGGGAGGGGNGGGGCCACAGGACTTCCTCCCCCGCTTGTGGAA GNCCCCAAACCCCGTTGNCCCCNGGGGCCGCNGNTTNTTTTNTTTTTTT^ TCTTTTTCTTGNNGGGCCCCTTTTTTTTNCCCCCCCCCNGTTTT^ NNNNNAAANNGGGGGAAGGGGGAACCTTTTTTGGGAAAAAAAAΠ

AAA

TTNAAAAANTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCGGACATGCTGGTCGTGCGAGTGGTTGAGATGTCCATCCTGGAGCCTGACGT

GCCCCTCCCACTAGTCCTCCTCTCCCAGCCCAGCTACCTCAAAGTCTTCGTCCCCAAGCAC ACCCAGGAGCTGCGGCTGGAGCTGCAGGGCTGTGTGTCCAATGGGAGCCTGGGCTGCCCT GTGCACCTTACCGTGGGGTCGGCCACCCTGCCAGGAAACTTCCAGAAGGTGCTCACTTGT AGCGATCCCACCACGGCCTGCCGCCTGTTGTTGCCTTNACCACCNTGGNAACGGNGGTTG CAAGTGACGGCCAAAAGCCTGGCGGGGCCCCGCGTGTTGGNNACGTTAATNGCCGGGGTT

GCCTTNACAGCTTGCANACCGTGAATTGCNAACTTCAANGGCNTTTTGAAAAANAAGCCC NAACCAAANNAGCACCGCNTCCACGGGCCCGCCGCCCTTGAGCCCCAACACCCAGGACCT GGACCAAAGTGGCNAGGCAGGCAGNGGCCCTTTNTGNTTAAGGAGCTTCCCCATCCTGCG GGAAAACATGGATGTGGNGTTTTGGGCCCTTTCCGGCCCCTGGAAAGGGCCTTGGNGGCT CGTGCAAGTCGGACATTGCCTTAAGNGATGAAAATTGCNCCTTTAACACGGGCATGGGAC

AGNGGGGGGCTTCCTTGAACANTTTTTTGGGAACCGTAAAACCAAAACCGNGGATTGGCC AACAACCACCCTNGGGGGGGGGCCTTGTGNGAACCGNCCGGGTTTGCCCTTTTNTTNAAT TTTAAAAANTTTGNTTTAAATTGNACCAAAAANCTTTTTTTCAAGGGGTAANCCCCT^ CCCCTTGANNGCCTTNGTTTTCCCAAAAGNCAAACCTTAAAANTTCCCTTACCCAAANAAA AANAAAAATTGG

NAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGCCGNCAGGACACAGGTGTCNTGAAAACCACCGTTAAACCTAAGCCAAAATGGGAAA GGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCAGGGAAGTCTACCAC GACTGGCCATCTGATCTACAAATGTGGCGGGATCGACAAGAGAACAATTGAAAAGTTCGA GAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAACT TAAAGCTGAACGTGAGCGTGGTATCACCATTGATATCTCCCTGTGGAAATTTGAGACCAG

CAAGTACTATGTTACCATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGAT TACAGGCACATCCCAGGCTGACTGTGCTGTCCTGATCGTTGCTGCTGGTGTTGGTGAATTT GAAGCCGGTATCTCCAAGAACGGGCAGACCCGTGAGCATGCCCTTTTGCTTACACCCTGG GTGTGAAACAACTAATTGTTGGCGTTAACAAAATGGATTCCCTTGANCCNCCCTATAGCCA GAANANATNCNAANAAATTGTTAAGGAAGTCAGCNCCTATNTTAANAAAATTGGNTACA

ACCCCGACACAAGTACATTTGGGCCAATTTNTGGCTGGAATGGGGACACCATGCTTAAAC CCAAGGCTAATTTGCCCTGGTTCAAGGGATGGAAAGTCNCCCGTAAGGGCCGGCAATTGC CNATGGGAACCCCCCTTGNTTGAAACCTTTGGAATGGANTTTTGGCACCAAATTTGNCCAA ATGGAAAAAANCCTTGGGGTTGGCCTNTTNCCGGAANGTNNTTAAAAATNGGGGGGGTTT GGGNCCTGGCCCCTTGGGGGGCCCGGNGGGNAAACTTG

TTNANAAAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCGAACAGTCCTCACGCCGATCTCTTTNCTGGNTCCCACCCGCGCCAGGTGAC ACGGAGAGCTGACACCATGGTTCATCAGGNGCTCTACCGGGCGCTGGTCTCCACCAAGNG

GCTGGCGGAGTCCGTNCGGGCTGGTAAGGTGGGCCCTGGCCTTCGGGTGCTGGATGCGTC CTGGTACTCGCCGGGCACCCGCGAGGCCCGCAAGGAATACCTGGAGCGCCATGTGCCCGG

CCCAGCGAGGCGGGCTTCGCCGACTACGTGGGCAGCCTGGGCATCANCAACGACACGCAT GTGGTGGTGTACGATGGTGACGACCTGGGCAGNTTCTATGCGCCGCGGNTCTGNTGGATG

TTCCGTGTGTTNGGCCACCGCACCGTGTCCGTGCTCAATGGTGGCTTCCGGAACTGGCTGA AGGANGGCCACCCGGTGACATCTGAGCCCTTACGCCAGAAGCCAGCCATCTTCAAAAGCC ACGCTGAACCGCTCCCTGCTCAAGACCTACGAGCANGTGCTGGAAAACCTTCGAATCAAA AAAGGTTTCAACTTGGTGGAATTCACNGGCCCCANGGGCGGTACCTGGGCACACAAGCCG GAANCNANATCAGTAGGACTGGAACTCGGGCCACATTCCGAAGGCTTCGGTCNACATTGC

CCTTTCATTGAACTTTCTTAAANGGAGGAATGGNTTTTTNAAAAAAAACCCAAAAGGAAA CCTCCCTTGCCCTTGTTCCAAGGGCCCAAAAAAGGNGGGACCTTTAANAAAAGCCCCTTTT TTTGGCCCCATTGGCCCGGGAANGGNGTCACCCCNCCTTGCCCCAATTGGCCCTGGGTTGN TTTAACCTTTNGG

AGCCTATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGTTTGCCGCNGNGACACAGGTGNCGNGAAAACCACCGTTA AACCTANTCCAAANTGGGAAANGANAANACCCNCATNAACATNGTTGTCATTGGNCACGT AGATNCAGGGAAGTCTACCACGACTGGCCATCTGATCTATAAATGTGGCTGGGATCGACA

AGAGAACAATTGAAAAGTTCGAGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCAAA TATGCCTGGNTCTTGNACAAACTTAAAGCTGAACGTGAGCGTGGTATCACCATTGATATCT CCCTGTGGAAATTTGAGACCANCANGTACTATGNTACCATCATTGATGCCCCAGGACACA TANACTTCATCAAAAACATGATTACAGGCACATCCCAGGCTGACTGTGCTGCCCTGATCNT TGCTGCTGGTGTTGGNGAATTTNAAGCCGCTATCTCCANGAACGGGCAGACCCGTGAGCA

TGCCCTTTTGCTTACACNCTGGGTGGGAAACAACTAATTGGTGGCGNTAACAAAATGGAT TCCACTGGACCCCCCTATAGTGAATCNNNATTACCANNNGGNGGNGAACCCTNNAANCAA ANAGGNTTTNAXNTGGGGGGNNTNNCGGNCCOSπsrGGGNNNGNNNNNNNGNN^ NNNNNNNNNNNNNNNNNNNNNTSπSINNN^ NNNNNNNMsfNNNTTTNNTNNNNTTNN^

CNNNNNNNNNNISlNNNNNCCNNTNNr^^ NNNNN(_ NINNNNNNNNNNNNNNNNNNN^ GNNCCTTANTAGNGGANGNGCGGCAATNTAACNGNGGGGAGGTCCCCANTTACCATTAAT

CTGCCTNNCATCCCCCNCGGAGCCTTGCATGAGCANATCNCCGGTCATCNGAGGAGAGNT

TTCACGNGGTCTCTTAAGAATACANGTGNCNGTGTCCTCAGGGGGGATCTGNTAATNTAN

TTTCTCCTTCTNTNAANCCGTNANAANNNN(^ATACAC AACGTANANTNAAAANTAANN NTCTTNNANATTTCTTNCAGNAGCGNNCANCCGCGCNNGCCNACTCNGTNTCAGNCNNNC

TNTTNNANNANGTAAAGNAGATNNTNGTGGAAANGGNAGGNTANNO^ANNNGNGNATTG TNCAGCAGCTNNTNNGACTNGNGNANGNCGNNTTTATNNAGGATCTNTAAAGNNNANNN NNNNNNTNTWANTTGCTNCTNNTATNTNGAGGNGGNANNNNNGNGNANTGNNTGA NAATT IN NGCGNNANNN ANTTTANGNGTCGGNGTNACNNCNCNGNAGNCGCATNANN ATTANNTGGNGTNTNTATNTTTA^GNTATO^

C GOSrCNNGNTTTNNTNTTN^

GGAGCTACGATANCGAATCGATαsπSfGTNNNGCNCGNNTNTGNTNCANTGCNNGGNNGCG CTGGCGNCGCTAGG(^TAANNNTTNCNNCCATNAANNGANGCAGNCTACNNANACNCAC TGACNGNTGATTACATTAGATTANGANNANNGANCANCNGNANTTGTCANANACTGCGTN αSlNCAACGNAGANGNNNNGCTNGANACNNTGNGNNTCTNTGNNCTNGTCAATNNGNACA

NTNNGNCNGGNAGGCAGTAGNNNAGTAATTCNCGCGNCANTNTAGCTNNGGACNCNGGA NCGTNANGCCCNNNNNTGTNNAANNGNGNCGGCNATNNGNCNTANNNTNANCANTGNNG CGCGCACNTTGTNATCTCCNCGCAGGNAGAATANCGAGNCGNNNGTGNGNGCTNTCNGCT ATGG(^GNANTCGCNNNCGTAANAGAGTGATNCNCGNNGGNNTANGCCGNGTNNNNNAN NCGCGNNTGTGNNNCGNNNCGNGNCGCNGACAGANTNCCNCGCNCGCGANTNTNCANCT

ANNNGNANCANAGAGNGCTNGTNTNTNNNNGAAGTTACGNNTTANNCAANCGNTAGTNN GTNTNANCANCGTCCNCNCGAANTNCCACNTCGTTGGTGTNTTANTNGNANNCGTCGNGT AGNTATCANTGNTGANAGCGNGNGGNNGCTGGCGTNNTCGGATANTNTCNGNGNCANTN AGNATGCGCGNTAGACAGTNANCNGNGGNNGNCATNAATCNGNGNTNGNCGNACNGTNN GCGACANAGTNANNTCGTGNCGANCAGTGACTNTCACGNTCNCNNNANTATCACNTNCCG

GANTNNANTGNNGCCGANTCNCNGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGANTTCNNNCACGAGGANATNTCTTTAANAGTAGGAGAGGGGCCAATAGCTGNCAT CATGACTCCAACTCTTAAACCNGGNTTNA(^GATTANTAANNANGNCNNTCATNANTCAC

NANANCCTGGNTCNTTATACNCNCGCTCNCATTO^

TNTCTTNNNTACANTNC^TNNNTNCATCTNNNANCACNTCTAGNNNTANTNCCGACATTC NOSrαSINCNTNTNCGNNANNCTNNNTNCCCGCTNTCTNCTCCNNAACTANTCTGNCATATC NCNGAGCCNCGTANTATGNACTTNNTISπNrC^^ NGACCTCTTNCTNCNTNATNlSπsrc^^

NNNGNTNANNCTNNTCANNTNNGCNTTACTCGAATNCGTATNNNATGTTNACNTTCTTTN CTTTNTNTCCNTTATTNNCTATNNCCANNCNGNAACNCNTTTTNCNTNCCNCTCTATNCAC NGTCMTC(^CCCCCTCTGTNCNACNCTNCTNTCNCGGCTNNCNTANTNCGAGNαS(NCCNTT ANCTGGGT(_^CGNGCTTCNNCNAGCTNGANGNNCNTCMNfCCCCNANANCTCCNTCCCCTT CTCTCTGTATCCCT(^TGNNTNCANNTCTATNNNTCNTATTNNTNAGTNCNANCANNCACC

(^ANTANTNNNATNCCNTNNTAC(^CNNCTCANNNCAC(-MNATNNTNCATNTACTAGNTT (^TTNCTCGCACGNNNCTCGCCTCTCTGTCCTCNTTNTNCTCTGTATTNCNNTNNCCNTGTT TANNCTTCCTACATCGTTNNTTTNCN^ TTCTTCGTCTTNCTTATCTNNTACTOslNTTTCNGTTCCCCTNCTCATCCCTCTCNA^ N(^TAACNTTCTCTAGCTTTTNNTNTGNATTCTOSfGNNTCCCTCTCTCCTACNTACCCCNNC

NGNAANTCTCTNNACCATTCTTCNNCCTCGGCTCC

GCCCTATCTGGAGCTNCANCNCGAGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGAGAGGTGCAACTTTCTTCGGTCGTCCCGAATCCGGGTTCA

TCCGACACCAGCCGCCTCCACCATGCCGCCTAAGTTCGACCCCAACGAGATAAAATGTAC CTGAGGTGCACCGGGTGGGGGAAAGTCGGGGNCCCGNTCTGGCCTTGNCCCCAANAANC GGGCCTTTGGGNCTTGCTN<^AAAAAGGGCGGGGATGAO^TNGCCNANGNNACTGGNGA NTGGAAGGGNCTGNAGANTACNGGGNAACTGNCCNTTCNNAACNAANNANCCCNAANTG NNGGGGNAC(^TTTGNTTNTGNCCTNNNNATTAAANCCC TAAGGNACCNCCCAGGGACC

GAAAGAAGCCGAAAAACCTTTAGCNCNNNGGAAACNTTACTTTTGATGAAAANGNCAAC NTTGNCOsrGNANANGCNGGATTGGNCTCTAACTNNANAACTTTNTGGAACCNTTNAAGAG ATANCTGGGGACCGCGCCACATCTGTGGGGCTGCAATGTGTGATGGGGCGCCACCCCTCA TGGACATCATTGANGATATNNAACACTGGCGCCCATGGAAATGCCCCCCNTTGTTAAANA ACTGCGCAGGGNNAATATAAGGNGCCCITΓΓTCACACCNCAAAAAAAAAAAAAAAAANN TTNGGGGGGGGGGCCGGGNACCCAANNTTTCCCTTTNNNNNGGGGGGNGNNNTTAACNC

NNNNNNNNNNNOWKΠCNCΠWTGT^ TNNNCOTTNTNTNNTTCTNNN^ TTGNNANTCNNNNGNTTNAANNNC T^ NNTTNCTTNTNTNTNNNTC

TTNAGCCTATANNGAGNCGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGNAGGAAAAAAAATTGTAGGAAGTCAGCACCTNTNTTAAGAAAATTGGCTACANCCC

NGNCACANTATGCATTTGTGGCNAATTCTGGGCTGNANGGGGNNCAACNTNCTAAACCNA ATGNCTATWANNCαWGGTTNAGGGANNGNAAGGCANCCGNNAGGGNCGGNATNGCCNN GGAAC(-MNCCTNGNTNNAACTTTNGATTGGATTNTNGCANCNACTTGCCCNANTGNNNAA NCCTTGNNNTTGGCTTTTCCNGNNGNCTATTAAAATGGGGGGATTGGTACTGGCCCTGTGT GGTCATGTGTGAGACATGGTGTTCTCAAANACTGTGNATGGTGGTCANCTNTTGCTCTCAC

NGCNATGTGNACACACTGAGNATGANACCTTGTGTAAAATGC^CCNCTGTAANCATTTTG TGAAAACCTNTN(^GNGGACACATGTGNGCTTTTTATNTGNAAAAAACACGTTTTGTNTA AAAATATCCCCCTTGGNANATNTGNGGTGTTGGANCANCACAAATGANNCCCCCCCTNGG ANACNT πsrCTNNGTTTNCANNCT(^CGANGNTTTTTNTTGNAANCT^ AGAGCTGGTATNTTGCCCCNNGTGNCTGNGANTNGTTGNCACCACANCTCANTAGCTTNC

ANANTNNGNCTGNAGCCCNAGANAAGAAAAAATAGATNNTTCCNTTTTTTTGGAAAAAA AANTNGCAAGGAAAGNNGCNCTCCATATTCTTCNAAAANAATGGTGGACGGACANCCCN CNATTGGTTTATTGNTTCGCTTGGGGGAANNCCCTNTTTTTTTTGAAAAAGNANNNTT^ ATTAANTCC3STCCCC(^GGGGGN(^CCNTTTTTTTNNTCCCCGACNNAGAAAAA^ CCCCNTTGTTGGGGGGNNTTC(^AANNAGCGGNCCTNAAAAGAGANGNTTTGNATNCTTG

CTTTNGGAACNCN

NGNCACANTATGCATTTGTGGCNAATTCTGGGCTGNANGGGGNNCAACNTNCTAAACCNA ATGNCTATNANNCCMSrGGTTNAGGGANNGNAAGGCANCCGNNAGGGNCGGNATNGCCNN GGAACCNNCCTNGNTNNAACTTTNGATTGGATTNTNGCANCNACTTGCCCNANTGNNNA^ NCCTTGNNNTTGGCTTTTCCNGNNGNCTATTAAAATGGGGGGATTGGTACTGGCCCTGTGT GGTCATGTGTGAGACATGGTGTTCTCAAANACTGTGNATGGTGGTCANCTNTTGCTCTCAC

NG(^ATGTGNACACACTGAGNATGANACCTTGTGTAAAATGCNCCNCTGTAANCATTTTG TGAAAACCTNTNCNGNGGACACATGTGNGCTTTTTATNTGNAAAAAACACGTTTTGTNTA AAAATATCCCCCTTGGNANATNTGNGGTGTTGGANCANCACAAATGANNCCCCCCCTNGG ANACNTNNCTNNGTTTNCANNCTCNCGAN^ AGAGCTGGTATNTTGCCCCNNGTGNCTGNGANTNGTTGNCACCACANCTCANTAGCTTNC

ANANTNNGNCTGNAGCCCNAGANAAGAAAAAATAGATNNTTCCNTTTTTTTGGAAAAAA AANTNGCAAGGAAAGNNGCNCTCCATATTCTTCNAAAANAATGGTGGACGGACANCCCN CNATTGGTTTATTGNTTCGCTTGGGGGAANNCCCTNTTTTTTTTGAAAAAGNAN^ ATTAANTCCNCCCCCNGGGGGNCNCCNTTTTTTTNINTCCCCGACMvfAGAAAAAAAANCNA CCCCNTTGTTGGGGGGNNTTCCNAANNAGCGGNCCTNAAAAGAGANGNTTTGNATNCTTG

CTTTNGGAACNCN

NAAAAGCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGCCGGGTTCGGATCGCGAGTCCGCGCCGCAGCGGGCACCGCGGT

CCGGAGCTATGGCGGTCGTCGTCCGAGTAGTTTATTGTGGCGCTTGAGGCTACAAGCCCA AGTATCTTCAGCTCAANAAGAAGTTAGAAGATGAGTTCCCTAGCCGTCTGGACATCTGCG GCGAGGGGACTCCCCAGGTCACCGGCTTCTTTGAAGTGTTCGTAGCGGNAAAGCTGGTTC ACTCCAAGAAGGGAGGCGATGGCTACGTGGACACGGAGAGCAAGTTTCTGAAGCTGGTG GCCGCCATCAAAGCCGNTTTGGCTCAGGCCTGATGTGGCCTAAAGGCAGAGACCAGTAAT

CGTGGCCCAGCCCCTCTCGGCAGACGCTTCATGACAGGAAGGACTGAAATGTCTCTTGGA CGCCTGGTCCTTCCCTGATGTTCTCGCGGCCGCCGGTTGGAGCANANATGGACACCCCTGG TCTTTGCCTGTGCGTGCGTGTGTGCNTGTGTGTCCCCCCACGCTGGTCCTGGTGCCTTCCCC ATC(^TCATNAACATGNTNTNACCAGCCTTCCCCATGTTATNCATTTATCTTNNNGCNCCT NGGGNGGNCCTAN^INTAGCTTCTTTTNNGGGGGAGCCNANANGNTAAANCGANGGTNAN TTTCAAATTTCANNGNGATGGAACAACTCANAANGCAATAAATGGNGATGAGGTTNCCCT GNTNNAANNTNTGNNTTNTNTNGGGGGNCCNNTTCCCCAANTGGCCAAAANTTGGGGNN

GGNNTNAANNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNANNNN

TTNTTGAACNANNTGNNTGGGANCCTCCNACCGGCGGGGGNGCGGCCGCTCTAGAACTAG TGGATCCCCCGGGCTGCAGGAAAAAAAAAAAAAAANTTTTGGGGGGGGGNCCNNGGNNC CCAANNTCCNNCGGGGGNGCGGNTTNAAAATANAAA(^TGNNCTAANCCAAATCαWNT

ATTT> NTI^ T IN]WTAANAGGGGATT^^

ATANACNANTCOS1NTCNNTANTATTNTAATNTNNAAΛACTTANAATAANATTGNNAGNAT TNGNNTTATTANCTTNCTCNATNANCNANNATTTTCNANNCANTAANANTNTATCTTANTT TNTNNANCTTATNANCTNTATTCTNAANATNANNANNNAGGANNATAGGNNCAAAGNNT CTCNNCCNNTANNTAGNGCGANNCCTNNCNCANN(^AAGGATNGN(^TTTNNNNCNGAN

NTANNGTNGNNCNNGCNNTGGNGCAATTAANCCAAANTNACAANCTCATGGTNGGNGGG TGTTNCCNACGGNTGACTAACCCTGGNGCCANTTTCTCTANTGTCNCCCAGCNGGNACTN NGTGGNANGTNTCCNNTGNNGTNTTGNANCACACNNACCCGTNTACCNTGACTTNAAATG GNTGGAATTTNCGGAAACTGNACTNAAAGNGANGGCCCACCCCNGTNGANNANCNTNNA TCCC(^TCAANNCCCCAAAANCTCAANNCATNCCTTNCAANANCCCAANGCCTCNAACCT

ANCCNNNCANTGNNTACTAAAANTTAATAAACAANNTTCCTNNNATNANACCTTANTAAT CαStNCANANGTTTNNNNGCCTNNAANGNTTTATCCGCGNNNNC(-^

NTNTCTNCCNNACATNNTNNCAANTAATCNATCNCNNTTANCNCNNCTNCTGANNNACCA ATNTNCNANNNNCTTGTTNCCNATTN^ NGCAATTTClSπsrAAACCTWTANAANTO

CTCNTNTCTANATAATNAANNATNNCACCATCTACCAACTTNCNCTNCCCNCCCANNCCA AGGNGNGCCCCTCTTTANTTNTNTTTNNNANCNTANTNTCANCATANNTACTNATATNNA ATTCC

TTTGANNNCNNTTGGAGNTNNNCTACAGGGGCNGNCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGGNGAAAANNACCNTTAANNCTAAGCNAACATGGGNAANGTNNTCACCCAC ATGAACNT(^TTGNNATTGNGCNNGTAAATTNATGGANGTCTACNACNACNGANCATATG NTCTANAAACNANGCTGGATCTATAAGAANCNAGCTGGGTCTATGANAAGTGGNCTTAAC ATGTATGACCACTTTTTTAANCAGCCANATCACAATGAAAACATCACTACTGTAATGCTTG

GCCCATGATGTTATTTCCTCACTATCAGTTGAGACCCAGCAATAAATATAAAACGTTGCAA AAAAAΛAAAAAAAATCTGNGGGGGGGGGCCGNGNTNCCANTTTNCNNNTANGGGNNNGT NTTTNNNNGNNTGGGCTTNNCCTCAANTTNTGCTGCTTNTTNNTGATGAAATT^ <3NNNTNTTTNCTNTCGAACNNNGCAATANCTC^ TTCTCAGTTTTNTAAACATTNNTANTNTTNNNGAGCTTTTANCN

GGNTNACNCTNNCNNTTTGCCTNATATTNTTATNCANTNTCNCCTTTTTTTCTN CCCNNGNCTTTTTTCTTNAANNANNATTNNNCTNTNTTCCTNCTT^ NNTTTTNCTAATTTTCTTNTCNT^^ TTNTCAATTTTACNNNNNTTANTTNNTNCTGGATTTT^ NGNNTANNTTTTCANACTTGNANANTNT<^^

TANNGTTCATTC(-^TGTTTNTCNATTCTNTNTTANNTANTCNNCTATGNT^

NTCNTNANNATTNGNANNTNTTTATTTNATNNTTTTCCCGN^

NNNCNN

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGAAGGTGCAACTTTCTTCGGTCGTCCCGAATCCGGGTTCATCCGA CACCAGCCGCCTCCACCATGCCGCCTAAGTTCGACCCCAACGAGATAAAATGTACCTGAG GTGCACCGGTGGGGAAGTCGGTGCCACGTCTGCCCTGGCCCCCAAGATCGGCCCTCTGGG TCTGTCTCCAAAAAAGGTCGGTGATGACATCGCCAAGGCAACTGGTGATTGGAAGGGTCT

GAGGATTACAGTGAAACTGACCATTCAGAACAGACAAGCCCAGATTGAGGTGGTACCTTC TGCTTCTGCCCTGATCATCAAAGCCCTCAAGGAACCACCAAGGGACAGAAAGAAGCAGAA AAACATTAAGCACAGTGGAAACATTACTTTTGATGAGATCGTCAACATTGCCCGGCAGAT GCGGCATCGGTCTCTAGCTAGAGAACTTTCTGGAACCATTAAAGAGATCCTGGGGACCGC CCAGTCTGTGGGCTGCAATGTTGATGGCCGCCACCCTCATGACATCATTGATGATATCAAC AGTGGGCGCAGTGGAGTGCCCCGCTAGTTAAGAACTGCAAAGGAAAATAAAGGACCATTT GACAACCAAAAAAAAAAAAAAAAACTNGGGGGGGGGCCGGGNNCCCAATTCCCCCTATA

GGGGGGNNNNNNNNAAAANNNNNNNNNNNNNNNNNN^ IWNNNNNN^

NNNNNNNNNNNNNNNNISINNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNTSπSENNNNNNNNNNNNC

AAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GANTTCGGCNCGAGGCAGAGGTCTTTAGAAGAAGGAGAGGGGCCAATAGCTGTCATCAT GACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAATGTAAGAAGTTTTCAAAGAC CTTGGGCCCTATAGTGAGTCGATTACAGNNGGANCNGGANTCNNNGANCNNATNGCTGNC TGAAAANAGGNGCTGAANTTATTGNTNGNCCNCCTGGNCNAANGATTGNCNTGTNNNCA

NNTANTANNGGNCNGNNTAOSrANNTTTNNAANAGNGACNNNTGNTGTTTTANANGAAN^ NNAOSnSTAANGTNGACTGGGNTTNGANCCCANGNNNTGa^CNTTGGGGATAANGNNCNCC CTNNCNNAC^WAαsϊNNTNTGNTTTNNNCTNCTTTCCCCANAN^ GANAANNCNNNNNNNCCCNTNNNNNNCNNGTNGNNGCM^AANNNN^ NGNNNrøCNNNNNANNGNNTSπW^

NNNNNNTTNCNANAANNNNGNNNNTGNNN^

CNNNNGGNNNNOSiNNNNNANNNNNNNNNANNNNNTNACCNNT^^ GGNNGNNTNNNNNNNNNNNNCCNNNNNNNNNNNNNNN^ NCCNNNNNNNNNNNTT^^ NNNNNNNNNNNNNNNNNNNNNNNN^^

NNNC] NNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NCCNTATCTGGAGCTCCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGGTCAGNNAACATCACCGAGCTGAATCTGCCGCAGCTAGAA NTGCTCAAGAACCAACTGGACCAGGANGTGGAGTTCTTGTCCACGTCCATTGCCCAGCTC AAGGTGGTTCAGACCAAGTATGTGGAAGCCNAGGACTGNCTGAACGTGCTGAAGAAAAA CANCGAGGGGAAAGAATTACTTGNCCCACTGACGAGNTNTATGTATGTCCCCGGGAAGCT ACNTGATGTGGAACATGTGCTTATTGATGTGGGAACTGGNTACTACGTAGANAAGACNGC

TGAGGATGCCNAGGACTTCTTCAANAGGAANATAGACTTCCTTANCAANCNAATGGAAAA AATCCAACCAGCTCTNCAGGANAAGCACNCCATGAAACANGCTGNCATGGNGATNATGA GCCCNAANATTCANCAGCTCACAACCCTGGGAGCAGCTCAGGCTANCGCCAAGGCCTGAG AGCTTGTTTCACAAATGGGGCAGAGGGTGCCTGCTTCTGGGGCCTGGGACTTTGTGGACA NTGGTTTCCTGGAATGGGGAAANAAAAAAGGTCTGTGGTTTAATGCTAATAAAATGAGCC

NNCTGGGCACANTANTCNNAGGTCNAAATTNTCCCNCNTNGGGGGGGGGNCNGGGCCCC

CAATTNCCCCTTNNTNGNGNGGNNCCOWTAANNNNNGANANGGNCNNTCNTTTTT^

ANTGNTNNNNNINTTNNNNNNGGNNNTATNNGNCTTNT^ NNTTCTTTCNNNGTTACTNNTTNN^ NNNNNGNNTNNGNNTTTNNN]S[NNNNTATCCNNNNNANNNT^^

GNAANACACNTATTISfNTATTTTTTTT^^ GTNANCNCNTNTTCNNNGGGANANNAGNAGATNANAACTTTGAGCNCNCTGGANTGCAN ACAGCGGNGGCCGCTCTANACTAGTGGATCCCCCGGCTTGCAGGNANTGNAAATTGTAAC

GANTNNNNACCNATANAANNAANATTGGCTNCGGGGGCCCNACNCANTATNTATNTTGTG CCANNTCTNTGGGTTCGTAATGNTGACTTTCATGCTANTAANCTTNGNTGCTANTNTGAGC ATGGCANAANGGGGATNGNTAAGTCACCCNTAANGNACNNGNNATTN(- NTTTGCAAAT ANTCTTGCTNGANANCTTTGGATTGCATNTNTGNTAANCAAANNTCNNTTCATNTTGANA NACCGTTTGCCNNTNGNCTTCTCCTNNGCATGGTCTACTATAANATNTNNTGGGCANTTAG

GNNACa rGTCGCCTTGCTNGNNATCaSTNCATTGNACACTTGNTNGTTNTCANAATCCTTGN GNAAATGGNTGGANCNNCCTATANGCTNCNAAACTNAAATTGANANNNATNCTGNNANN AGAAAGNNNNTNGTNANANANNTNCACTCNTTNNANGACANNNTNNNCNTATCGAAANN CTCTNTTTNTCNTGGNTTANCAATTCGCGNNTAGaSfTNNTAANT INNTTA AAANNGNGT NACTANTCACAAATNNNNANTTTNNNGNNπ

CTTNNACTATNATNATTGTATTTCAA(^ACANNTNGTANANNACNTNCTTGGCTTCTTTCA CATGCTTTCTNNAGNTGNNANTCATTTTT^

TTCNCTGNNTATTTTNATNAACNTNGATGNGTNNGCCATTGNNTAACNCTAGTNACCTAN ANACTTGGTATNATGACAATATTAATNANCN(^TCNCTCTTGN(^CNGNNTTGNAATTAA

AACAANTATGTNTCTNANNNCNTACTCGGATAATNCNTACTNGTGGNTAAACANAATTGG NGCCTTTAANATTNTATANTTNNAATAACTC

GNNGNTAGANNTANTNGGNTNANTTNCNTGCNATNTANGNTCTCNCTTNNCTNTNGTNTN TAATCNACNACATNC^TTNTCTATNTNTTATNNAANNGCCCTANCTNTCTCNTNGTNNCCA CNANTAACTNACANNATGNANCTTGTNTCTATNTNCTGANCTCACTATCGANNNANTTAT

ACCTNTNTCTTTCNCTCTACNATATTACTANCTANNTCNOSINNCNNGNTCGNANANAACA ATCGNGGTCACTNTNTCGNNAANNTCTGCTGGGGACATATNNGTCG

GNAANACACNTATTNNTATTTTTTTTTNNNNNNTNTTNTCNCT^

GTNANOSrC^TNTTCNNNGGGANANNAGNAGATNANAACTTTGAGCNCNCTGGANTGCAN ACAGCGGNGGCCGCTCTANACTAGTGGATCCCCCGGCTTGCAGGNANTGNAAATTGTAAC GANTNNNNACCNATANAANNAANATTGGCTNCGGGGGCCCNACNCANTATNTATNTTGTG CCANNTCTNTGGGTTCGTAATGNTGACTTTCATGCTANTAANCTTNGNTGCTANTNTGAGC ATGGCANAANGGGGATNGNTAAGTCACCCNTAANGNACNNGNNATTNCNNTTTGCAAAT

ANTCTTGCTWGANANCTTTGGATTGCATNlTSrTGNTAANCAAANNTα^WTTCATNTTGANA NACCGTTTGCCNNTNGNCTTCTCCTNNGCATGGTCTACTATAANATNTNNTGGGCANTTAG GNNACCNGTCGCCTTGCTNGNNATCCNNCATTGNACACTTGNTNGTTNTCANAATCCTTGN GNAAATGGNTGGANCNNCCTATANGCTNOSfAAACTNAAATTGANANNNATNCTGNNANN AGA AGNNNNTNGTNANANANNTNCACTCNTT^INANGACANNNTNNNCNTATCGAAANN

CTCTNTTTNTCNTGGNTTANCAATTCGCGNNTAGCNTNNTAANTNNNTTANAAANNGNGT NACTANTCACAAATNNNNANTTTNNNGNNTTNCAGNCNAATCGNNGCNNTTTGNGTTACC CTTNNACTATNATNATTGTATTTCAACNACANNTNGTANANNACNTNCTTGGCTTCTTTCA CATGCTTTCTMSrAGNTGNNANTCATTTTTTTGANACTNATCNNCAATGNANTANATTANAN TTCNCTGNNTATTTTNATNAACNTNGATGNGTNNGCCATTGNNTAACNCTAGTNACCTAN

ANACTTGGTATNATGACAATATTAATNANCNCNTCNCTCTTGNCNCNGNNTTGNAATTAA AACAANTATGTNTCTNANNNCNTACTCGGATAATNCNTACTNGTGGNTAAACANAATTGG NGCCTTTAANATTNTATANTTNNAATAACTCCNANGTNNGNCNCANNCTTNTTANANTAT GNNGNTAGANNTANTNGGNTNANTTNCNTGαSTATNTANGNTCT(^CTTNNCTNTNGTNTN TAAT(^ACNACATN(^TTNTCTATNTNTTATNNAANNGCCCTANCTNTCTCNTNGTNNCCA

CNANTAACTNACANNATGNANCTTGTNTCTATNTNCTGANCTCACTATCGANNNANTTAT ACCTNTNTCTTTCNCTCTACNATATTACTANCTANNTOSrCNNNCNNGNTCGNANANAACA ATCGNGGTCACTNTNTCGNNAANNTCTGCTGGGGACATATNNGTCG

TTNAACAACAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAATTCGGCACGAGGGCGGTGACGGCCGAGGCGACAGAACCGAGGGGCTG TCGTTGGTGGGCGCTCCAGGGCTCTGAACGAGAGAAGCGTGACCCGGAAACGGAAGCGA GTCCCCATCCCAACTCCGCCAGGTTTCACGCTAGCCCCAGGCTTACTGGTAGGCTCCTGCT GCCATGGACCTGTTGTTTGGGCGGCGCAAGACGCCAGAGGAGCTGCTGCGGCAGAACCAG

CGCGCCCTGAACCGGGCCATGCGAGAGCTGGACCGTGAGCGACAGAAGCTCGAGACCCA GGAGAAGAAAATCATCGCGGACATCAAGAAAATGGCCANGCAGGGCCAGATGGACGCGG TCCGGATCATGGCGAAAGACCTGGTGCGCACCAAGCGGTACGTCCGAAAGTTTGTGTTGA TGCGGGCCAACATCCAGGCTGNGTNCCTTAAGATCCAGACACTCAAGTCTAACAACTCAA TGGCACAAGCCATGAAGGGCGTTANCAAAGCCATGGGCACCATGAACAGACAGCTTGAA

GTTGCCCCANATNCAAAANATCATGATGGAGTTTTGAACCGGCAGGCAAAAATTATTGGA CCTTGAAGGANGGAAATGATTAACGAACNCCCTTTNNTGACNCCATTGGGGGAACCAAGG ACCAATTAAAAAGGAAAAGNGATTGCTTTTTTTAACCCCCAGGNNCTTGGGACCAAATTG GGGGTTGANNCCTTGAAAAAANTAAACTTGGTCNAAACCTTTNCNTTTTCCCCCGGGNGG GTTTCαSfTTAAACGTTGGGNTTGCCCGGGGGAAAAAAAAANCCNAAGGNTTTCNGNCCTT

TTGNCCTTGGGGGGGAC^CCAAACCC(^TNAACCTTTGGAGGGAAAAGGGTTTAAAAAAA CTTTTTAAAAGGGAATTGAAATTGGCCCNNGCTTTTTNCCAAAGG NAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGNCTTCNACCTGANNCCTGCCAACNNCTNCTACCNCTNCCAGGCT CTNCACNACNNCTACCNCGNCTGCATTAACGNNAANGGGACCTNTNCGGCCCTGGACNNG GT(^TGNNC(^σSfTGNCAGTCAGNNGGNNNNNGGGGGACCAGNTNNNTNCATTCCATNN NNACNCTNCACNCTTCACCGNCATGCTTGACATGGNTCAACACTNACNTGTGNANGTTCT

CNCNCATCGAGANCTTNTGNNACTGAGNTACTCTNCTGCTGTGTTGCNTTNNGCCCCNGTT GACCCCAGAGNNNACCNNNCNACTGGCNGAAACCCTGCCCTCCTGCCTGCNTCNTGCGCN NGGGACGNGGGTNTNAAAAGACATGCTCGAGCCNGGATGGGGACCTGGCNTGGCCNCAC GTTCACTGTCNNCNGGCTGNCCTCTATGNTNGGGAACGGAACCCCAAGNGGCGGCGGGAC TGACTCTTTCCCCTGGCTGGGNGATGCANACCATGANTGCCTNTNCATCTATNTCTGATGC

NTCANTACAACATGCGTGCTGGTACCCGATTTTGGGCCCCGGTTGGTCCGGACGATATGCC TTTTAAACTTACATCCCGCACTGGGACTTTCCGAAGCTCTTNANAANTNANNNNTTNGGGN

GGGGANNNCCNNCCGGGNGGAANGGNAANNNGGNAACCCTTCCAANAAAACCAANGGT TNNCCCTTNCNNNAGGGNNNANGNNNNNC(.^^

NNNNNNNNAGGAGTTTTGAAAACCCTTTTTNTTTCAAGNNTTT

TTTGGAAANCAACAATTTCTGGNANGCTTCCCACGCGGCGGGTGNGCCGGGCNCGCTTCT TAGAAACTAGGTGGGAATCCCCCCCCGGGGCTTGCAGGNAAAANAAANAAAAAAAAAAT

NTNTNNGGGGGGGGGGGNCCCCGGGANCCCCNAANTTTCCNCCCNTTATAAGGGGANGT

NCNNTNTTNAANAANNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNl^^ NNNNNNNNNN NNNNNNNNNNNNNTSf^^ NNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNTNNNNNNNNNNNNN^

NISINNNNNNNNNNNNNNNNNNNTNNNN^

NNNNNNNNTSπSlNNNNNNNTSfNNNNN^

NNNNNNTSFNNNNNNNNNNNNNNNNNNNN^ NNNTNNNNNNNNNNNNNNNNTNNNNNNTN^

NNNNNNTSINNNT^^

NNINNNNTNNNNNNNNNNNNNNNNNN^ NNNNTNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNN lSttWNNT^^ NNNNNTNTSiNNNNNNNNNNNNNNNNNNT^^

NNISπStNNNNTNNNNNNNNNNTNNNTN^

Nl^NNNNNNNNTNNNNNTSπSTNTSINNN^

NNNNNNNNNNCNNNNTNNNNNNNNNNNNT^

NNNNNNNNNNNNNNNN^ NN NN NNNNNTTNTNNNTTNNNNN ^

NNNNNNNNNNNNNNNNNTNTNNNNNNNNN^

CC

AGNCNATCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGGTGAAAACCACCGTTAAACCTAAGCCAAAATGGGAAAGGAGAAGACCCACATCAA CATCGTTGTCATTGGGCACGTAGATTCAGGGAAGTCTACCACGACTGGCCATCTGATCTAC AAATGTGGCGGGATCGACAAGAGAACAATTGAAAAGTTCGAGAAGGAGGCTGCCGAGAT GGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTGGACAAACTTAAAGCTGAACGTGAGCG TGGTATCACCATTGATATCTCCCTGTGGAAATTTGAGACCAGCAAGTACTATGTTACCATC

ATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGCACATCCCAGGCT GACTGTGCTGTCCTGATCGTTGCTGCTGGTGTTGGTGAATTTGAAGCCGGTATCTCCAAGA ACGGGCACACCCGTGAGCATGCCCTTTTGGCTTACACCCTGGGTGTGAAACAACTAATTG NTGGCGTTAACAAAATGGATTCCACTTGAGCCACCCTATAGCCAGAAGAGATACGAAAGA AATTGGTAAGGGAAGTCAGCACCTATATTAAGAAAATTGGCTACAACCCCGACACAGTAG

CATTTGTGCCAATTTCTGGCTTGGAATGGTGACAACATGCTTANAACCAAGTGCTAATATG CCATTGGTTCAAGGGATGGAAAGTCACCCCGTAANGGACGGCATGGCCAGTGGGAACCCC CCTTGCTTTGNAACCTNTTGGATTGNANTTTTGGCCACCAAATTTGGCCCAAATGGAAAAA ACCCTTGGGGTTTGGCCTTTC(^GGAGGTTTATNAAAATGGGGGGGATTTGGGNCCTGNC CCTTGGGGGCNGG

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGAATTCGGCACGAGGGCAGTTAACATCACCGAGCTGAATCTGCCGCAGCTAGAAATGCT CAAGAACCAACTGGACCAGGAAGTGGAGTTCTTGTCCACGTCCATTGCCCAGCTCAAGGT GGTTCAGACCAAGTATGTGGAAGCCAAGGACTGTCTGAACGTGCTGAAGAAAAACAACG AGGGGAAAGAATTACTTGTCCCACTGACGAGTTCTATGTATGTCCCCGGGAAGCTACATG ATGTGGAACATGTGCTTATCGATGTGGGAACTGGTTACTACGTAGAGAAGACAGCTGAGG

ATGCCAAGGACTTCTTCAAGAGGAAGATAGACTTCCTTACCAAGCAAATGGAAAAAATCC AGCCAGCTCTGCAGGAGAAGCACGCCATGAAACAGGCTGTCATGGAGATGATGAGCCAG AAGATTCAGCAGCTCACAACCCTGGGAGCAGCTCAGGCTACCGCCAAGGCCTGAGAGCTT GTΓTCAGAAATGGGGCAGAGGGTGCCTGCTTCTGGGGCCTGGGACTTTGTGGACGTGGTTT CCTGGAATGGGGAAAGAAGAGGGTCTGTGTTTAATGCTAATAAATGAGCCAGCTGGGCAA

AAAAAAAAAAAAAAAAAAAAANCTTGGGGGGGGGCCCGGGGCCCAATTTCCCCTTTTGG GGGGGNNNNNNNNAANANNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNN^

ANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGCNANGGNGTCAGAGCTGTACGACGTCACTTGGGAAGAAATGCGAGATAAAATGAGAA

AATGGAGAGAAGAAAACTCACGAAATAGTGACAAATTGTGGGAAGTTGGGAGAGGAATT AATTAGTGAATATGCTTCTAAGCTTGGGAGATGATATTTGGATCATATATGAACAGGTGAT GATTGCAGCCCTCGACTATGGTCGGGATGACTTGGCATTGTTTTGTCTTCAGGAGTTGAGA AGACAGTTCCCTGGAAGTCACAGAGTCAAGAGACTAACGGGCATGAGATTTGAAGCCATG GAGAGATCGATGATGCTATTCAGCTATATGATCGAATTTTACAAGAAGACCCAACTAACA

CTGCTGCAAGAAAGCGTAAGATTGCCATTCGAAAAGCCCAGGGGAAAAATGTGGAGGCC ATTCGGGAACTGAATGAGTATCTGGAACAATTTGTTGGAGACCAAGAAGCCTGGCATGAA CTTGCAGAACTTTATATCAATGAACATGACTATGCTAAAGCAGCCTTTTGTTTANAGGAGC TTATGATGACTAATCCTTACAACCACTTATACTGTCAGCAGTATGCCGAAGTTAAATATAC CCAAGGTGGACTTTGAAAATCTCGAACTTTCAAGAAAGTATTTTGCCCAGGCATTTGAAAC

TTGACCACNGAAATTTGANNAGCTTTGTTTGGAαsπ TCATGGCTGCAAGNCATATTGCTT CTTAATCCCAAAGCCNGGNC(^AAACNAAAAAANACCC(^TGGANTTTTGTTTTTTGGGC CCCCCNNCAAAAAACAAAANNTTNTTNNTTTT^ NTTCTTTTNTTNAGGGGNTTTNAAAACTTTTTGNAANCCNTGNGNAANNCCCCCN^ GGGGGNAAATTNGNCCCCN

NNNNATCTGGAGCTCCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCAACTTCGGNGTGAGCACTGTGCCCGCTTCCTGGCTGACCGCTTTGTGGAGGGTGTG TGTCCCTTCTGTGGCTACGAGGAAGCCCGGGGTGACCAGTGTGACAAGTGTGGCAAGCTC

ATCAATGCCATTGAGCTCAAGAAGCCTCAGTGTAAAGTCTGCCGGTCGTGCCCTGNGGNG AAATCCTNTNANCACCTGNTTCTGGACCTGNCTAANCTGGCAGCGCGGGTGGAGGAATGG TTGGAGAAAACNTTGCCTGGCANTGACTGGACTGNCAACGCCCGGTTCATCATTCGTTCTT GGNTTCNAGANGGCCNCAAGCCCCGCTGTATAACCCGAGACCTNAAGTGGGGAACCCCTG TGCCCTTANAANGGTTTGAGGACAAGGGGNTCTATGTCTGGTTTGATGCCACCATTGGCTA

TTTGTGCCATTACAGNCAACTACACANACCAATGGGAGAAGTGGTGGAACAACCCACAAA CAAGTGAACCTGTNTCAGANTCATGGCCAAGGACAATGTNCCCTTCCATGGCATATANCT TTCCTTCTTCANCCCCTATGAGCTGNGGACAANTACACCTNTNGNCAANGCACCTCATTTG CTTACANAAGAATTCTTGAATTACNGAGGGANGGGGAAAATTTCTCTTANTAAAACCCCN GGTGTGGGGAGNNGTTTTGNGGGACANTNTNCCACNNAACACAAGGGAATNNCCNGGNT

TGACAATNNGGGNGGCTTTTITATTNTTGCTGGAACATNTNTTNCCTGAAGGGGGCAANA AAAAAANTGCCTTTTTTNNTTGGNNCAAAAAATNTTTNTπ

NTGNNGNCCCCAAACTNNTTTTN AACAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCT GNAGGAAATTCGGCACGAGGCTTTTATTGAGACCACCCAAGGACCCCAGGGGACCCACAC CTGGGGTNACGGTATCCGGGGNTNTAANCCαsrAAANNGGGGGNTNGTTTTCCNANCCCCN

NGTTGNCCCNNCNANGGNNNAGNCCCTTTTTTGNNCCNNGCNNGGAANGNAGNANTNAN

NNNTAAAANCCAACNTCTTTNAAOWTC^ANCCCAANNCTTCCCAANCCNAAANCTNNAG

GGNANTTGAAAAGAAATGAAAATGGGNTNGCACAATGTGNCACNGAANTAGAAACCCTT

TTTATAAAGAGATATTATAATATNGGGGCCCCATNTTCGNGNNCAGGTTACANTTTTGTGG NCAGGATAAAGTTGNGTGTGNCTANACCTGTGCCTGTGNACANCTCTTNNNGTGANNNCA

CAAGATαSfGAGCNCAGNNTNAAANNGCGCTCTNTTTTGTCACGAGAGNNCAAAGNCNNA NGNGTGNCCACACAACACATANGNGTGNGNATGTGNACACACCACCAAGTGANANATGA CACTNTGATAATATTTATAAAAAATATATTGTGTNTGTGTGNNAAAAAAAAAAAAAAAAA ACTTNGGGGGGGGGGCCGGGNCCCCAANNTTCCCCTTTTAGNGNGGGNNNNNANAANNN NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNISINNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNlSπsiNNNNN

AACAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCT GNAGGAAATTCGGCACGAGGCTTTTATTGAGACCACCCAAGGACCCCAGGGGACCCACAC CTGGGGTNACGGTATCCGGGGNTNTAANCCCNAAANNGGGGGNTNGTTTTCCNANCCCCN NGTTGNCCCNN(^ANGGNNNAGNCCCTTTTTTGNNCCNNGCNNGGAANGNAGNANTNAN

NNNTAAAANCCAACNTCTTTNAAOSINTαsrANCCCAANNCTTCCCAANCCNAAANCTNNAG GGNANTTGAAAAGAAATGAAAATGGGNTNGCACAATGTGNCACNGAANTAGAAACCCTT TTTATAAAGAGATATTATAATATNGGGGCCCCATNTTCGNGNNCAGGTTACANTTTTGTGG NCAGGATAAAGTTGNGTGTGNCTANACCTGTGCCTGTGNACANCTCTTNNNGTGANNNCA CAAGATCNGAGCNCAGNNTNAAANNGCGCTCTNTTTTGTCACGAGAGNNCAAAGNCNNA

NGNGTGNCCACACAACACATANGNGTGNGNATGTGNACACACCACCAAGTGANANATGA CACTNTGATAATATTTATAAAAAATATATTGTGTNTGTGTGNNAAAAAAAAAAAAAAAAA ACTTNGGGGGGGGGGCCGGGNCCCCAANNTTCCCCTTTTAGNGNGGGNNNNNANAANNN NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNTSTNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNTSINNNNTSINNNNNN^ NNNNNNTSINNNNNNNNNNNNNNNNNNN^ NNTSINNNNNNNNNNN

TTNANCNCTATCTGGAGCTCCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCTCGTGTGAGTGACATCGTCTTTAAACCCTGCGTGGCAATCCCTGACGCACC GCCGTGATGCCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACTTCCTTAAGATCATC CAACTTCTGGATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAACGTGGGCTCCAAG CAGATGCAGCAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCTGATGGGCAAGAAC

ACGATGATGCGCAAGGCCATCCGAGGGCNTCTGGAAAACAACCCGGCTCTGGAGAAACT GTTGCCTCACATCCGGGGGAATGTGGGCTTCGTGTTCACCAAGGAGGACCTCACTGANAT CAGGGACATGCTGCTGGCCAACAAGGTGCCAGCTGCCGCCCGTGCTGGTGCCATANCGCC GTGTGAAGTCACTGTGCCAGCACANAACACTGGTCTGGGGCCCGAAAAAACCTCCTTNTT CCAGGCTTTAGGCATCACCACNAAAATNTCCAGGGGCNCAATTGAAATCCTTGAGNGATG

GGCACCTGATTAAAACAGGANACAAAGTTGGGCNCCANCNAAACCCCCCNTGTTGAANAT GCTGAACATNTTCCCCCTTTTTCNTTTGGGCTGGNCATTCCACCAGGGGGTTTGAAAAATG GGNGCATTTTACAANCCTTGAAGNGGNTTGACATTCACAAAAAGGAAAACTTTGNANTTT CCCCCTTTCTTGGGAGGGGGGNCCCCCAATTTTTTNCCCANCGGGTGNCCTTGCCAAANTG GGTTANCCCCAACCCGNNGCATTTTGGTNCCCCC^TTTTTTTTATTTA^

ANCN<^CTNCTTGGGTTTTTTTTTTC NAAAAAGGGNCAANGGNCCT NAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGNACTAATAANNANGGNNAACNATGCATTCATCGGACCTTNCAGCCCCATCAAACATTT CATCATGATGAAATTTCGGTTCCCTCCTGGGAATCTGCCTAATCCTACAAATCCTCACAGG CCTATTCCTAGCAATACACTACACATCCGACACAACAACAGCATTCTCCTCTGTTACCCAT ATCTGCCGAGACGTGAACTACGGCTGAATCATCCGATACATACACGCAAACGGAGCTTCA

CTTTCCNAGAACATGAAANATTGGNGTANTCCTTCTGCTCACAGTNNTAGCCACAGCATTG

TGNGGTCCTTCTACCATGAGGACAAATATNATNCTGAGGAGCAACAGNCATACCAANCTC

TTATCAAGCAATCCCATACATCGGCACAAATTAAGTCCNAATGAATCTGAGGCGGATTNT CANTAANACAAGCANCCCTTTACCCGATCTTCGCTTTCATTTATCCTTCCATTATCATCATA

GCAATTGGCATAGTCCACCTACTATTCTTCCACGAAACAGGCTCCAACAACCCAACANGG AATTTCCTCAAACGTANACAAAATCCATTTCCACCCCTACTATACCATTAAGGACATTTTA NGGGGCCCTNTNACTAAATTCTAGCTTTTAANACTACTAAGNACTATTTCGCANCCCGACC TTCCTNGGANACCCAAANAACTACCCCCAAGCCAATTCAATTNAANACACCCCCTTNAAA

CCAACTTNGGNGGGNGTCCTTANCCCTTA

TTNANNAAAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGGTAAATCTGTCTTTCCTTTTGGCACATAGAATCTGAGACTGAAAATTGTNGA

AGGAAAAGAGATGACAGCTGAGTTCTGGGTGGAGTTGATGAGCCCAAGGACTGGGCTGTT TGGGCCATATCCTGTTCATGGGTTTTGCCACCACTATAGAACCTTCTGTGGTCTCCCTTGCG AAAGGGGCACAGCTCGTCAGCGTATTTAAGGAGTGACCAGAGTGGAGAGCATGAGGGGA ACAAACAGGTGGGGGCTGTTATCCAGAGAACAGTGCTGCTTTTCTGCAAGACCTTCTAGG GTAGTATAGAATGGTGTTGGGAGCAAAGACTTTAGAGTGACAGAGAGTCCTAACAGGTCT

CTTCACTTTCTCTTTGGCCTGCAGGGATAATCCTACAGGTCCCTAATCCCTTATTTGAAATC TTTTGGGATGGGTGGTGTTTTGGAATTCAGGATGATTCAGATTTTAGAAAGGGAATATAGT GCCTTTATGATACATAAAGTAATACCCCAGTGGAGATTCAGGGCAGTGCCCTACTGGAAT TCAAATCTATCAATGTTTCTGTAGCTAAATATATGAATATTCNCACTAAGTGGAGATAAAT AGATNTTATAAATAGGATCGGNGACGGGTCAAAATCAAAATTTTGGGTCAAAGTTATGNA

ACAAACCTATTGTTTCTTTCANAAATTTTTTTTATTTTGGAAATTATAAA^ TGGGCCTTAATAATTGGTNCCCCAAGGGTGGTGGGGGAAGGNAATAATGTGNCCCAAAAA AGCCTTTTTAAAC(^(^CCCCCATTGGGAAGGGATTGTATGCCAATTTTCAATTCCCAAAA CAAAAATACCAAATGGTNCCCAAGGGGGGNGGGCCTTTTTTGNACCTTACAGGGGGNCCA ATGGTNCCGG

NNCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGCTTTCCTGCAAAGTAGGGCCACACAGAATGTTGCAACTACC GGAGGTTTTTTTGATNANAATNTGACTNCCAGNCTTAAGCTTCTAAATTNCTGATTTAGTT

GAATCTTGGTGAGAACCANAGGCCGGAACTCAGCTGCCCCAGGACTGTCCAAGGAGCAG GAGCAAGTGGTGGCCCTGAACTGATGCGGTGCCCGGAAAGCATCTGTGGCCAGCGTGCTG GGGTTAACAAGACCTTGGTCATCCACCGAGGAAAGCAGGAAGTTGTTTCCAAAACAAGGA GGAAAAAATAGATGCTGAAGAATCAGAAGCTACAGCTGTGCAGCACAGGCTGCCCTCAG ACCTGGATGGACATAGCCCAAGCCCCAAGACGAAAAGCTTTCTGTGATACACTGACATGT

TTATAACTGTCCGTGATCTTGGGGGCAGGCACCAGAATTCCTCTGTCTGTTGGAGAAAATA GGCATAGAGACCTTGGGCCAGAATGCTAAACCCGGAGAGCAGGGCGTGAGCCACTCTTGC AAGAAAAAAGTGAGAAGGACGTGTGGGCTTNCATCTTGGGCAGATGGGANAATGCAAAA CAAAAAAANCGTGGGGAANANATGGGANCCANGCNAACNGGAAGGCTGANGGCATGAC AAGGNCAGTGGGGCTTCCCAGTGCAGGGNCCTTAAANGGAGTCTGANTACCTAACTTGNC

CCATTAAACCCCTTTGTCCGTTCCCAGCCC(^AACACCTTATTAAAAGTTAATTTTTTACNC CCTGNAAAAAAAAAAAAAAAAAAACTTGGGGGGGGGGCCCGGGCCCCCAATTTNNCCCT TTTTGGGGGGNGGGGG

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGTGACCTCCACCCATTGTCTTGGTGGCACATGGGTGGAACACTTG ATCTGCTCGAGTCTGCCTTCAACACACATTGCATCTTCAGATTTTCTACTTTTCTGTTCAAA ACTAATATTCACCAAGTCAGACTTTGTGTTAATTTTATATCAGGGTATTGGCTGCCAGGGG GTCATCCCTAAGTGGCCTGAAGATGGACAAAGGGAAGTAACAGGCACGTGATGTTGGCAA GGATGCTTCTAGGGCTAGAGGATCAGTGGTGGGAGAGAGCTGCAGAATCCACCAGCCAG AACTGCAGATAACGAATCTTATGGTCAGGGGCTGTGACTGAGAGAAGGAAACTGAGGTTG TGTTCTGAAAGTACATAAACTCTCACATATACCCAGTTCTTCACCATCTCCCCTCCTCACTT TGCAGTGCCATTTCTTTTTGCATTAGGCAATTTGCTCAGACTTTCCAGAGCCATGGCCCATC

CGTTCTCTGGAATCCCCCACACCTCTGAGAGGTGGATCACCACGTCCTGCAGGGCTGCTCC CCTCCAAACTACCTTTAGGAGATGCAGGACAGGGAGGCTGTTTCAACCAGAAAGACCAAA ATCAAGAACCGAGGAGCAAAACGTGGTAAAACAGAAAAANGGCAGGTGGCAAATGGGTT TCTTTTGGGGTTTCTGGTTTCTTTTTTCACATCNGGGGATGGCTGNCACCAANAAATCTT^ AGTCCGCTTACATGGTNCTTCTTNTTNTNCCCTNCCCACTTTTTTTTT

AAAATTTCAAAAGCCAATNGGGATGGGCCGGATCTCACAGGCTGGAAAAACTCGTTCCCC TCCAACCATTTTATTGAAAAAAGCTGGTTNTTATTAATNATTGCCAAACCCTTTGGCCCGG GGNGGAAAANATTTGACNAATNTTTTNAAA

NAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGATTTCGGCNCGAGGGAAGCACGTCGTCTTCATCGCCCAGAGGAGAATTCTGCCTAAG CCAACTCGAAAAAGCCGTACGAAAAATAAGCAGAAACGTCCCAGGAGCCGCACTCTGAC CGCTGTGCACGACGCCATCCTGGAGGACTTGGTTTTCCCAAGTGAGATCGTGGGCAANAG GATCCGCGTGAAGCTGGACGGCAGCCGACTCATAAAGGTCCATCTGGACAAAGCTCAGCA

NAACAACGTGGAGCACAAGGTTGAAACGTTTTCTGGTGTCTATAAGAAGCTCACGGGCAA GGATGTTAATTTTGAATTCCCAGAGTTTCAGTTGTAAACAAACGACTAAATAAAATATTAT TCTCAAAAAAAAAAAAAAAAAAAACNTGGGGGGGGGCCCNGNCCCCNATTNCCCCTTAT NGGGNGNNTNTAANANNNNNNNNNNNISINNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNTSINNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNTSINNNNNNNN^ NNNNNNNNNN'NNNNNNNNNNNNNNNNNW NNNNNNNNNNNNNNNNNNISINNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNW NNNNNNNNNNNNNNNNNNNNNNNNNC

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGAATTCGGCACGAGGGGCTTCCAGGGAATCCCTCTGTTGAGGACAACTGGCTGTCTTC TCCTGCACCCTCCCCCAAACAACCCTCAACTGCTAGACCCACCATGAAACCACTGGGTTCT GGGTCCCAGCTGCTGATTCTAGAACCCCGCCTCTGTGCTGCATCCTGGTCCCATCCCCTAN ATCTAGAACTCAGCCCACTGGATTCTANAACCTCCATATTTACCTCACCTCGAGGCTCTTC CATCCCCAAGCTGTGCCCTGTCCCCAGCTTTGGTGAAAGANAGGGGCCCCTTATGTGTGCT

GTGTTGTGTCTGCTGCACTTGGTTTGCAGTTGGGAGCGGAAGGCAGAAGGGGTGTGATTG AAGTGTGTCCAGAGATGAAAAAATACATATATATTTAACAAAAAAAAAAAAAAAAAAAN NNGGGGGGGGGNCCNGGNCCCNANTTCCC(^TATAGGGNGNNGGATNAAAANNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNISINNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^ NN NNNNNNNNNNNNNTSINNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

C

TTGAAAACANTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCTTTTATTGAGACCACCCAAGGACCCCAGGGGACCCACAC

CTGGTGTCACGGTATCCGTGGGTCTCAGCCCCAGAATGGTGGGCTGCTTTCCCAGCCCCCT GCTGTCCCCACCAAGGGACAGGCCCCTCTCTGTGCCCTGCCTGGGATGGAGGACTCGATC ATCAGATACGAGCTCCTTTGAACATCCAGCCCCAGTCCTCCCCAGCCCAGAGCCTGAGGG TCATTTGAGAGGAAGTGAGAGTGGCATGCAGCAATGGACAGGACTCAGAAGCCCTTTTAT AAAGGATATTTAATATCGTGGCCCCAGCTTCGTGGCAGGTTTCACTTTTCTGGCCAGGTTA AAGTTTGGCTGGGCCTACGCTGCCCTGAGCAGCTCTCTGACTGTAACCACACGAGCTGAGT GCAGTGGATGAATGCGGCCTCGTTTCTGCCAGGAGTGCANAGTGCCAAGCGTGGTCCANA CACGACAGATGCCGTGTGCAAATGTGGACNACGACCCAANTATGACATATGACTCTGNAA TATTTCTAATNNANATATTTTGGTTTCTNGGCTGAAAAAAAAAAAAAAAAAAAATT^

GGGGGGGNCCCCGTNACCαSTTTTTTCNC<^TTTTNTNGNTS[NCCTNTATA^ TNNNTCTCCTCMstNNTNCπCC

TNCACTNC ΠSINTTNIWCNNTNNCHNNCTNCTGNNNNN^ TNNTNNGTCGTTNNTNGACTNCTNNNCTTTCTTGGTTNNNCCNANNT^ NNNQLRWCTCNCCTNTNCNNNNATTNTN^

NNTTCTNNTTTATNNCC

TTGAAAACANTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCΓΓTTATTGAGACCACCCAAGGACCCCAGGGGACCCACAC

CTGGTGTCACGGTATCCGTGGGTCTCAGCCCCAGAATGGTGGGCTGCTTTCCCAGCCCCCT GCTGTCCCCACCAAGGGACAGGCCCCTCTCTGTGCCCTGCCTGGGATGGAGGACTCGATC ATCAGATACGAGCTCCTTTGAACATCCAGCCCCAGTCCTCCCCAGCCCAGAGCCTGAGGG TCATTTGAGAGGAAGTGAGAGTGGCATGCAGCAATGGACAGGACTCAGAAGCCCTTTTAT AAAGGATATTTAATATCGTGGCCCCAGCTTCGTGGCAGGTTTCACTTTTCTGGCCAGGTTA

AAGTTTGGCTGGGCCTACGCTGCCCTGAGCAGCTCTCTGACTGTAACCACACGAGCTGAGT GCAGTGGATGAATGCGGCCTCGTTTCTGCCAGGAGTGCANAGTGCCAAGCGTGGTCCANA CACGACAGATGCCGTGTGCAAATGTGGACNACGACCCAANTATGACATATGACTCTGNAA TATTTCTAATNNANATATTTTGGTTTCTNGGCTGAAAAAAAAAAAAAAAAAAAATTTNTN GGGGGGGNCCCCGTNACCCNTTTTTCNCCNTTTTNTO^

TNNNTCTCCTCNNNNTNCTTCCCTNTNT(^ANTGNTCTNNTCTNNTN^ TNCACTNOSΠNFNTTNTNCNNTNNCNNNCTNCTGNNNNNNNTNNTNGN^

TNNTfclNGTCGTTNNTNGACTNCTNNNCT^ NNNCNrWCTCNCCTNTNCNNN^ NNTTCTNNTTTATNNCC

TTNNNAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCTTTGCTGAGGGTCACATTGAGCTCCCAGCGACTTCAGGGGCATCTTTAGGA GTCAGCACTATGGCAGAAGACATCCAGGCCAAAATCAAGAACTACCAGACTGCTCCTTTT

GACAGCCGCTTCCCCAACCAGAACCAGACCAGGAACTGCTGGCANAACTACCTGGACTTC CACCGNTGTGAGAAGGCAATGACCGNTAAAGGAGGTGATGTCTCCGTGTGTGAATGGTAC CGGCGTGTGTACAAGTCCCTCTGCCCCATATCCTGGGTGTCAACTTGGGACNATCGCCGGG CAGAAGGCACGTTTCCTGGNAAGATCTGAACTGGNTCCATCCCACCTTTTNTGTCCTCCGT CCTTCTCCCCAGGGTGGTGAAGGGGGACCGGGGTACATGGTGATCCCCACCNTGGGATCC

TGACTCATGGTATAACTAATAATAAATGCTCGTTGGAAACGTGAAAAAAAAAAANAANA AAANCTTNNGGGGGGCCCCGNANCC^ATTNNNNCNTATAGNGGGNNNNTTANNNNNN^ NNNNNNNNNNNISIN^ NNNNNNNNNNNNNNNNNNTSINNNNNNNW

NNNNNNNNNNNNNNTSINNMSINNNNN^ NNNNNNNNNNNNNNNNNNNNCNNNNNN^ NN NNNrø^NNNNN^^ NNNNNT

AAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGCTANNCTCGAGTTTTTTTTTTTTTTTT^

GTGATGAGNANTAATNNGNC^AAANAGGNNNCCANTTTTTGTNGGGAAACCAANCCCCA CCCACAGGGGAOSπSITTTTCNNGNACCNAACGTANTCCCCNCNTTTTCNTGCCNAGGANGG

CNNTAANCCCCGNAAAAGGNCCCCCGGNNTGAGGNTCCAGGNCCAAACGGCCACNCNTC CGGCCCCANGGGGCNTTTTTGNANAGGNGGTTCCNGGGNACGGGGAAAGGGNCTNTCAA NTNGGNCGNGANCTGGAGGGTTAAGGNTNAAAANTGGNGCGGGTACAAAAGCTTTCNTA CCCNTGNTTTTNAGGNGTTTNACTGAGTTCCTCCTTGGCCATCANCNACANATGCAATANC TTGCCCTNAAGNAACCGGATGNTCGCCCAAC(^TGTTNACTTGCCATTTTTGTTTTAGNAA C^CCANCAGGNCCGGGNATTGGNAANCTNTTTCNTTGAATNAACNGGGGGGGNNAAAAA AACTTTCTATCNCCCGGGAAAAAGNCCCCTTCNNTTGCCGGGGANGGGCCCNTGANCCCC GGAGGANANAANCCCCTTGAGGGGGTCNNAATCAAGGTTCCGGGGGGGGCCCGGANCCC AATTNCCTTAAGGGGAGNNNNNAAAAN^^

NNNNNNNNINNNISINNNNNNNNNNNW NNNNNNlSπSINNNNNNNNNNNNNNNN^ NTSINNNNNNNNNNNNNNNNNNNNNIS^

TNNNNAAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGTTTTGAACCATCTGTTGAACAAGCCAGATATAGCAGCTGCCAACAGAATGT GACTCTGGAACCCCCTAAAGCCCAGGAGGTGACCTCACCTTGCAGACTGAGCCACTCAGC TGGCCCCCACGCTATGACGCAGGGGGACAAGGAGAGCAGCTCCAGAAGCCTGGCCCCTG GTACCGCAGAGAGCGAAGCCACGCTCCANCGGAAGCTCCGGCAGAAGCAGCTGCAGCAG

CAGTTCCGCGAACAGATGGAGAGACAGCAGCGGGCCGCCACCTCTGCTCTGCCCGCCGGA AGGACCGACCAGGCGCAGCCGCCACCGGTGCCTGCTGCCAAGCCCAGCCTCCCCAGGACC CACTCACCTCCAGAGCCACTCACCCAGAGAGACCTGCTCCCAGACAGTCTTGAAATGTGG GACATGGCTTTGGATGCAGAGGACAGCGTGCTCANGCCCTTGTTGAAACCAGAACCACCG CAGACCCCTGCCATCTCGGTCCTAAAGAACCACATGGAGACCCAGAACAGGATCCCACCA

AGCCTTTTGCCACCAGAATNCACAGGCACAGTCTGGGACCCTGGCACCTTCCAAACTNCC AGCCTTAAACCAACACACCACAAGGCGACTGNGATTCCTTNTAGGAAGATTCAGGACATG AAAAAAANGGAAACTGGGATCCCCCTTAANCCCCAGGGTTAAGGTCACCCTCCTAAAACT NTTGGCCTGGAGGGGACTTTCCTTTTGGTCATGAAAAAGAACTGCTNCTTGCCNTGAAGA AGGGGCCTTGGCTTTAAGGGCTTCCNCCTTGNTTTATTCTNAANNNNNGGGGAGGNAAAA

NNNNCNTTNNNAAAANAANGGGGGGGNAAAAANNNNNNTTTTTNNAAAA NT

TTNNNCACANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATNCGNGACNAGGCCTCGNTGNCCACCTGGCATTCCTCCGACTNCTCTCCA GNCGGGCCTCTCATAACATCACATATCACTGCGAGAATANCATTGCATACATGGATCATG CCANTGGGAATGNANANAAAGCCTTGAAGCTGATGGGGTCAAANGAAGGAGAATTCNNG GCTGNANGAAANANCNNATNCACATACNCAGTTCNGGAGGATGGTNGCACAAAACACAC TGGGGANTGGGGCAAAACAGTCTTCCAGTATCAAACACGCNAGGNCGNNANACTACCTAT

NGNACANATNGCNCCCTATGATNTCGGGGGGCCTGATCAAGAATNTGGTGCNGACATTGG CCCTGTTCGNTTTTTATAAACCAAACTCTATCCAAAGTCCCAGAAAAAGCTGNACACTCCA TATGTTCCTTTTGTTCTAATCTTGTNAGCCAGNCCAANNGACCAAGGTCNAGTTCTTTATTT CCAACACCCCTTGGNAAAACAGCGCNCCNCGNCCNAGAAAAGGATATTTGGTTGTTGCTA TTACCCCCAAATACAGTTCAAAAGCTTAATTGGACTATTTTTTTTACCAATTTCAATπ

ANTGGCCCAATGGGGCNATNAAAAAANAAACTTCACACTTTTTCCAATACCCTGGGGTTA (^TTTNTTTGAATCCTAACNCCATTTTAAAAGCAATGCCGGGGCNTTACCCTTTAAAAGAA TTNCCTTTTTTTCTGGAACCANTTCACGCCCGGAAAATTNGGAAAAAAAACTTTCCTGGπ TTAAAATAANCCTNAANCTTGGGNNANAAAAAAATTAACNGGAAATTGNTATGGGGNCC CCCCCAAAAAAATAAAAAAATTTTTTNCCCAAAAGN

NCANNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCAGAGCCCGCGGTCCGGACTGCAGCGCGTGCCCCAAGCTCTCCGTCTTCCCCCGC CCGCCAGCCCGAGCCCAGCCCGCGGCCCCAGCAGCAGCCCCGAGAGCAGCCCCAAAAGC

AGCGCCATGGCCGGGTGGAACGCCTACATCGACAACCTCATGGCGGACGGGACCTGTCAG GACGCAGCCATCGTGGGCTATAAGGACTCGCCCTCCGTCTGGGCCGCCGTCCCCGGCAAG ACCTTCGTCAACATCACGCCTGCTGAGGTCGGTATCCTGGTTGGCAAAGACCGGTCAAGTT TTTTCGTGAACGGGCTAACACTTGGGGGCCAGAAATGTTCTGTGATCCGGGACTCACTGCT GCAGGATGGAGAATTTACCATGGATCTTCGTACCAAGAGCACCGGTGGAGCCCCAACCTT

CAATATCACGGTCACCATGACTGCCAAGACGCTAGTCCTGCTGATGGGCAAAGAAGGTGT CCACGGCGGTATGATCAACAAGAAATGTTATGAAATGGCTTCTCACCTGCGGCGTTCCCA GTACTGACCTCGTCTGGCCCTCCCCTCACCACTCCCCACTGCTTCTGCACCCCTCTCCTTCC ACACACATACATACACCATTTTTATTTTTTGGGCCATTACCCCACACCCCTTATTGCTGGCA AAACCACATGGGCTGGGGGCCCCGGGCTGGATGGACAGACACCCCCTGCCACAACCCATA

CCCC CTGTGTGTGG GGGAAAACTTTT GTT

AGAATTCTATTACAAAAAAAAAAAAAAAAAANCCTTGGGGGGGGGGCCGGGGCCCCATT

TNCCTTTTTAAGGGGGNGNNNNNNNNNNANNNNNNN^ NNNNNNNNNNNNNNNNNNC

NAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGANTTCGGCACGAGGGGGGAGTGAAGATCTGCTCCTCCGGGTGCTAGCCATCACCAGC TACTCCATCCCAGAGAGCATCCAGAGCCTGAAGTGCCGCCGCTTGCGTGGTGGTGGGGAA

CGGCATCGGCTGCGCAACAGCTCGCTGGGAGAGGCCATCAACAAGTACGACGTGGTCATC AGGTTAAACAGTGCCCCTGTGGCTGGCTACAAGCAGGACGTGGGCTCCAAGACCACCATG CGTCTCTTCTACCCTGAATCCGCCCACTTCAACCCCAAAGTGGAGGACAACCCTGACACAC TCCTCGTCCTGGTGGCTTTCAAGGCCATGGACTTCCACTGGATTGAGAGCATCCTGAGTGA TAAGAAGCGAGTGCGAAAGGGCTTCTGGAAACAGCCTCCCCTCATCTGGGACGTCAACCC

CAAACAGATTCGGATTCTCAACCCCTTCTACATGGAGATCGCAGCCGACAAACTGCTGAG CCTGCCGATACACCAGCCACACAAGATTAAGCAGAAGCCCACCACAGGGCTGTTGGCCAT CACCTTGCCCTTCACCTCTGTGACCTGGTACACATTGNTTGGCTTCGGCTACCCAGACCCC ACCANAAAAAGCAGTCCATTCACTACTATGAGTATATCACGCTCAAGTCCATGATGTGGT CANGCCCACAATGTCTNCCAAGGAGGCCCNTGGCCATTAAAGCGGGATGCTTGGAAAAAT

CGGAACCGGNCAAAAACCCTTAACTTTACTTTTTGACTTNGGGCAANGGCTTGTTCCCATT GGGNNNAACCCTTGNTAAACNGGCCCCCGGCCCCNNCCTTTTGGGGGGGGCCAGGGGCCC ACATTGGGGCCGGTTTTGGACCTCACCTTTTTCTTGGGGGGGGGNGGGGGNCCAGGNTTA AAAANAAAGGCCNCCCCCTTTGGTTTTTTTTGNGNGAAGNT

AAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGCTCCCGTGCTCCCTCTTTTGGCAAACTNGTNGAGTACATGACTCAGTCANACAGGAG

NTCTACCTCACAGNCNACNTGTNNNCTANTNGCNAGANAGACTTGNGTCACACTAACGTG GNCCACNACCTGCCGGAAATGCATTGTTCANAACACAGAANGAAATTTANGATTTTTGCT

TTTCTGTGACNGNATTNGNTTCCGTCTCANNTCNGAGGNGTNAA(^GCATGTTNNTNTNG ANANNGCNTATTTAACATTGATTGNGANAACCNGGGAATTNGGCTCAAAANCTNGGAGC NTGANAGGAACCTTATAATGANGCATAGNGTCATTCATTATANCGGGACCATNGANGGAT NCTNTTTCATCCTCTCTCANNGNANAAATCANGACNNGGGTGCTTGTGGCANANGGNTTT CCAACCTCGGTAGAANTAACTGNATTGCANGTTCNACTCCCTCACCGAGGNGACCTGNTT

CCCATCTGTCTNAANGAGCANAAGACTNGATTGNTNNCANTGGCTCTAATAAGNAANAAT NCNNCATTTACNACANGGTANNGGGGNNTTCNTTNTTTNNNCANTCTNNTCCNNGNCCAT NCANCCACCCGANCCAATATTTCTNCTTCCCTAGNNNAAAAANTCTNTACCTTCNCTGTNA TNTATATNTNNGNNGNGCNNNTTTTTNTCTTACCTNTNTANNTNCCNCCGCAAGGANNCTN ANAAGTTAANTNATTGNNTTNCATCNGCACTCGCNNCTNNTNTAACGNNNTTGNTNTNTG

GTCCCCNNANCNANTNGCCCNNATAATTNNCCCNTTCNTANNTNTGNANCCANNTNNGCN NNOS1NTTCTNNCTAGGATCGCCACCGATANNGNATATCCACCGNANTCTCCCTCNCTTTNA TANNGTNAGNAACAαSπsrAWGNNTNNAAAGOSfGCTCNTαsrCNACNGNTTNTNCTACNAN NNTTAACATANNNGGAAGNNC

]WCNATATTGTGTNATTATTTTTNTNT^^ IWTCATCNCAATNTTNCTTNATCWGGN^ NGGANTNCATNACAGTGGCGGCCGCTCTAGAACGAGTGGATTCCCCGGNCTGCAGGAAAT

GTNCCNCACGAGGGG(^TNAANGTTNCC^AGGTANGTNGGCTNCNNTGGGNGNNTTANT GTNNCANNAAGGACTNCACNCANACANTTTNCATGATCAGTTCATTATNATTTCTTTNANN TTTTAAATCTNNNANTCCTCANCCACTCCCTCTTNATTANNNTANATCTTlStNNN^ NTTAATNTNNACCTTTTTCTCTATANNTNTCTCTGTNANCTGNGNCNOSfGTCTANNCNTTC NTANTCGAGCTCTNTAATTGTNTACTTATTTCCNAAACTNNGTTTCTCATTCCCNCNCCATA

NANNATNNTCNNTACATANNCGAGNCANATTTCC(^CTTTANTGNNTACCTTTTCANANA TATATTGACKACGTCTTTTANNTTTTTNNNTNTCANTCATCAN<^GATNN CTCCCNTNANACCTANAACANTGTNTNAAANAA(^CTATATTTACTCNTTATNTTATAATC NAGTGNTCNGNNNACTCGNATANTCANTATNGCNTSTANANGANCTAGNNGCCACNNTTNN GNNANTATTTTNGAJSTTCTCCATNT^

TNTTGCAACAGNTNNGCCCTTNNTNNTAATNCTCTACNTTNTTTATTCCACCNNANGACCC TC(^CTANTANTAACHNGATNANGC<^TTANTTNANNTACTCCATCACNTCGTCTACTACA NGAGG(^ACNNCTNTGTTGANTNNNCTOSfTCAANNNNTNNNNTNACCTCTATTCT(^ TANTACTTTCCCNNNAATNTACTTNTCCGTATATNTNTNNTTAAGANCNNCTNNTANNATG

AAATANNATTATTTNTATTANCTCTTCTNNTTANTTCTCTNCGCATNTTNTN^ GAC(^CNTCATNTATNN(^TCTCNANAGNTNTTNTATrWNCTATNNNNNCANNNCCNT^^ TACTAGTANACCAATNNCTCAGNTCGGCNATNNTTATGTGCCCNC(^CNNNGTCCCCACT ACCTNAAAACCNTNGGNGANNCTNNGCTNNGNTTNTGNAAATANAACCCCCCAATTNTTT ATAAACNTGNNGNOS(NNT<_ CTTCCT^

ATCNAANTANGTATTCANNNAOSfTCGCGTATATATAAACNTNNGNATNCTNTNCTCTATN ATCTTATCNGTACOTCANAOSπNINACGTT^

ATOSINCCGCANCGTCTCTTATNTATCTM^CNACTCATCTANNGTTACGTGACTNTCNATAN NGTATCTAATTTTNNATTTNATTTTANG

NNCNATATTGTGTNATTATTTTTNTN^

NNTCATOS[CAATNTTNCTTNATCTNGGNANAATTTAN>WAGACCNCNATTTGAGNNACNC

NGGANTNCATNACAGTGGCGGCCGCTCTAGAACGAGTGGATTCCCCGGNCTGCAGGAAAT GTNCCNCACGAGGGGCNTNAANGTTNCCNAGGTANGTNGGCTNCNNTGGGNGNNTTANT

GTNNCANNAAGGACTNCACNCANACANTTTNCATGATCAGTTCATTATNATTTCTTTNANN TTTTAAATCTNNNANTCCTCANCCACTCCCTCTTNATTANNNTANATCTTNNNNNN^ NTTAATNTNNACCTTTTTCTCTATANNTNTCTCTGTNANCTGNGNCNCNGTCTANNCNTTC NTANTCGAGCTCTNTAATTGTNTACTTATTTCCNAAACTNNGTTTCTCATTCCCNCNCCATA NANNATNNTCNNTACATANNCGAGNCANATTTCCCNCTTTANTGNNTACCTTTTCANANA

TATATTGACNACGTCTTTTANNTTTTTNNNTNTCANTCATCANCNGATNNTNCANACTANT CTCCCNTNANACCTANAACANTGTNTNAAANAACNCTATATTTACTCNTTATNTTATAATC NAGTGNTCNG πSINACTCGNATANTCANTATNGαsπsrANANGANCTAGNNGCCACNNTTNN GNNANTATTTTNGANTCTCCATNTTNTAGTCN(^CACACTANACTAACTTTNATNATTTCC TNTTGCAACAGNTNNGCCCTTNNTNNTAATNCTCTACNTTNTTTATTCCACCNNANGACCC

TC<^CTANTANTAACNNGATNANGCCNTTANTTNANNTACTCCATCACNTCGTCTACTACA NGAGGCNACNNCTNTGTTGANTNNNCTCNTCAANNNNTNNNNTNACCTCTATTCTCNTNN TANTACTTTCCCN INAATNTACTTNTCCGTATATNTNTNNTTAAGANCNNCTNNTANNATG AAATANNATTATTTNTATTANCTCTTCT^ GACCNCNTCATNTATNN(^TCTCNANAGNTNTTNTATNNNCTATNNNNNCANNNCCN^

TACTAGTANACCAATNNCTCAGNTCGGCNATNNTTATGTGCCCNCCNCNNNGTCCCCACT ACCTNAAAACCNTNGGNGANNCTNNGCTNNGNTTNTGNAAATANAACCCCCCAATTNTTT ATAAACNTGNNGNCNNNT(^CTTCCTCNCNANOSINNTTNTACATAαS[CCCCTCTATCTTAN ATCNAANTANGTATTCANNNACNTCGCGTATATATAAACNTNNGNATNCTNTNCTCTATN ATCTTATCNGTACNTCANACNNNACGTTNNTTNCNCCGATTTAAGTNATTNNCNCGNNNN

ATCNNCCGCANCGTCTCTTATNTATCTNNCNACTCATCTANNGTTACGTGACTNTCNATAN NGTATCTAATTTTNNATTTNATTTTANG

TNNANAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGCCGGACACAAGGGGGAGCGTGGTTACCCCGGTAACGC AGGTCCTGTTGGTGCTGCCGGTGCTCCTGGCCCTCAAGGCCCTGTGGGTCCCGTTGGTAAA CACGGAAACCGTGGTGAACCGGGTCCTGCCGGTGCTGTTGGTCCTGCTGGTGCTGTTGGCC CAAGAGGTCCCAGTGGCCCACAAGGTATTCGAGGTGACAAGGGAGAGCCTGGTGATAAG GGTCCCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGGTTGCAAGGTCTCCCGGGTCTT

GCTGGTCATCATGGCGATCAAGGTGCTCCCGGTGCTGTGGGTCCCGCTGGTCCCAGGGGC CCTGCTGGTCCTTCTGGCCCCGCTGGCAAAGACGGTCGCATTGGACAGCCTGGTGCAGTTG GACCTGCTGGCATTCGTGGCTCTCANGGTAGCCAAGGTCCTGCTGGCCCTCCTGGTCCCCC TGGCCCTNCTGGACCTNCTGGCCCAAGTGGTGGTGGNTACAAATTTTGGTTTTTGATGGAA ACTTNTACAGGGCTGACCAANCTTGCTTACCAACTTTTTTTNAAACCCAAGGATTATGAAG

TTGATGCTTACTCTGAAATCTCTCAACAACCAAAATTGAAAACCCTTNTTACTTCAAAAAG GCTTTAAGAAAAAACCCAACTTGGACAATGCCCGAGACTTTGANACTCAANCCCNCCCAA AAATGGGAGCAAGGGGTTACTAACTGGGAATTGGACCCCTTAACCCAAGGGATGGNCCTN TTGGGTTGCCTTNTTCAAAAGNATACCTGGGGAAATTTNTTTTANTTGGGGGAAAAACTTG GNTTTCC^GGGCTTCAAACCTTGAAAAAAAATTCCCAAATNNAAAAAAACTTGGGTACCA AAAAAAATTTCCAAGGGGCCA

AAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGNGAGGGNAACCATGACATACAGTGATGCANGGAANAANACGAAGTGGANGGCANAA TAGCTATAGGAAAGCNGCTGGACTTGCACTGGAGGAGCTGGACAGGTCTTTTGGTCAGCT GGTCTTGCAGCCACACCTCTTGGTCCTGGAGAGAGAGAAAANAANTGCTGNTAGCANAGC TGCTGAAACACCTCTTN(^TTCC(^ANCCTCTTTCACAAAGGCATTTGAACTCTTTGGCAT TCTACACAATCTACACTTACGGATCCTCACTTGACACTCGCCTTCCTCTGGCTCCCCTGTTT

CAGGGCAGNANAAGCANANNGAGGCTTTTTGTGAAATGAAAGGCNGCATGTNGGAAAAA GAATGNCTGGGAAATAGGACAGGAAACTCCTCTTNTAAAAAGATGGGTGTGGGGTGACA ANTGCAGGCACACCTGGNTTCAANTTCTANCTTCAATATATGACTGGCTATGGGGACTTTG GNAANANNTTTAACCTTCTGGGCCTCATTTTTCCNTTGGAAAANGGANCAAACCCCTACCT TACANGGGTGGTTGNGAGGATTAAATTAAATGANATGNGTATGTAAAGTTTCTAACNCAG '^'

NGCCTACATATTGGGGGTCCTCAATAAAAGGGAACCAGCAGCTNAAAAAAAAAAAAAAA ANNNNNNNNNNTNINNAAAAAAAAAA^ NTTTNNNAAANNNTTNNNCCCCCCCNGGGGTTTTTTTI^ TTTTTNNNNNNNNNNNNNNNNNNNNTTT^ (^CNNNNNNN NNNNNNNTTTTNNNNNGGGGGGNGN^

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCAGCAGCCTAAATGTGCAGACTTTGTAACCAAGCCCACCCGAGATCGGTCTGTGCT TTCACGTGACCACCATCTGTGCCTCCCTCGCTCCATCCAAATTTGTGTAGGCAGCTCCTTG

GAGCCATTCCTAAAAATATAGCTACACCAGGCCCTGGAAACTGTAGTCAAGTAACAGGCT TAAGTGTTTTCCCTCCTTGAGTTAAACCTCCATTAGATCTCTTTTGAGGGACCTTTCAGCTG CAGGCATCAGTGTGTTCTGACAGCGAGACACGTTATGTGTGTGTTTTCTATCTGGATCCAG GGCATCAGGATACAGTTCATCTTCTTGTACTTCCTCTCTGGCATGCAGTATTTCTGGACTAT GTTTATAAGTCTGTTTAGTAAAGGGTGGGATAGAGGATACCAAGGGAGTTTCCAAGGGAC

AGAGATGGATCAGTTAACGATAGTCAGAAATGAACTTAAAAGTTGCCTTGAAAAACCAAT CACATCTTATCAGGACGCATACCTTTATGTTTTCTAGCTCCTGTCGCTGAACTGGTTGCTGG GTAGCCCGTACATTTCTATAAATCCTGCTGGACTCAGTTCTCACTGTACTTCCAAAGAACT TCGATCGNGGGTTTACATGGACATGTATTTCAGGGGAGTGTTTACAAAGGGCGGATGGGC CCCATATANTTGCCTGGGNAAATGAACCCCGGGGANGGGTCCTTTNAAATGGGCNAAGNT

TTTTATTAA<^(^AAAAAAAATAACCCCTTTTGAA^ GGGGCGGGGGTTTTNTTTTTTNTGGC iNNGG GGGTTTTTTTTAATTTTTTTNGGGGGGGGG

ACAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCCGCCATGGGCTGTCTCGGAAACAGCAAGACCGAGGACCAGCGCAACTAGGAGAAG GCGCAGCGCGAGGCCAACAAGAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTA CCGGGCCACGCACCGTCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGT GAAGCAAATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACC

CGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCCACCAAAGTGCAGGACATCAAA AACAACCTGAAAGAGGCCATTGAAACCATCGTGGCCGCCATGAGCAACCTGGTGCCCCCT GTGGAGCTGGCCAACCCAGAGAACCAGTTCAGAGTGGATTACATTCTGAGCGTGATGAAC GTGCCGGACTTTGATTTCCCTCCCGAATTCTACGAGCATGCCAAGGCTCTCTGGGAGGATG AAGGGGTGCGTGCCTGCTATGAGCGCTCCAACGAGTACCAGCTGATTGACTGCGCCCAGT

ACTTCCTGGACAAGATTGATGTCATCAAGCAGGATGACTACGTTGCCCAGCGACCANGAT CTGTTCCGCTTGCCGNGTCCTGGACTTCTGGAATCTTTGAAACCAAGTTNCAGGNGGACAA AAGTCAACTTTCCCATTGTTTGACGTGGGCCGGCCAACCCCNATGAACCCCCGCAAATGG ATNCCAATGCNTTCAATGAATGGGACTGGCCATTAATTTTTNGGGGGTGGCCANCANCAA NTTTCNAAATTGGGGCATTTTNGGGAAGGAAAAACCAAAACCAAACCCGCCTGGGGNGG

AAGGGCTTTTGNAACCTTTTTTNAANANN GCCNATNTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG. CAGGCTCCCATGCTCCCTCTTTTGGCAAACTGTAAGTACTGTCTCAGCAAACAGCGATAAT TTCACAATTTCCTCTCTAGAATTGCTGAGAGACTTGAGTCACCAAACGTGGTTCACTACTG

TGGAAATGCATTGTTCAGAACACAGAAAGAAATTTAAGATTTCTGCTTTTCTGTGACAGTA TTTGTTTCCGCCTCAGTTCAGAGTGTGAACTGCAGGTTCCTGGCAAGACTGCTATTTAACA

TTGCATGTGAGAACCTGGTAAATAGGCAGAAAATCTTGGAGCTTGAAAGGAACCTCAGAA TGATTCATATGGTCATTCATTAGATTGGGACCTTTAAGGGATCTCTTTCAGCCTCTCTCAGT GCAGAAATCAGGACAGGGGTGCTTGTGGCAAATGGCTTTCCAACCTCGGTAGAGTAACTG CAATGCAGTTCACTCCTCACGAGGGAGCCGGTCCCATTGTTAAAGAGCAAAGACTGATTG CTTTATTGGTTCTAGAAGCAAAGCCAACTTACAGAGGAAGGGGATTTCTTTAAACAGCAG

TTCAAGCAAAAGCCAGATTGAACAAATTTTGCTCCCTGAAAAAAATTTTACTTCAGGGGG AGTAATATTGTGGGNTATTATAATAATCANGAATCGTGAGAATGATGAAAATATAATGAT GCTAGCCAGCTTAGTCCATTAGTAAANCACTGATTATGTACCACACACTGTCCTAAGTGCT TTATGTNNATTGAACCCNGTGTAAACTCTCAAAAATAAACCCTTATGGAGANNGGGATAC CATTATTCCTCACTTTTTTAAATGAAANAAACTGANGGCCCAGAAAAGGNTTTTACAGTNN

TTNCACANNTTAANTAA(_^SINGTAGCAGGNGGGGNCNAGGNTCCAANAACCTNGGCNTCTT AACTACTGNGCTGNCCCTGCAGNGGGGANCCCNTGGNTNGTTNTNTCCCT

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGANTTCGGCNCGAGGCTTGCTTCTCTAGGGAAGAATCCAACCGATGCGTACCTGGAAGC CATGATGAACGAGGCTCCAGGGCCCATCAACTTTACCATGTTCCTCACCATGTTTGGGGAG AAGCTGANCGGCACAGACCCAGAAGACGTCATCAGAAATGCTTTTGCCTGCTTTGATGAA AAAGCAACTGGCACCATTCAGGAGGATTACCTGAGAGAACTGCTGACCACAATGGGAGA CCGGTTTACAGACGAGGAAGTGGACGAGCTGTACAGAGAAGCACCTATTGACAAAAAGG

GGAATTTCAATTACATCGAGTTCACTCGAATCCTTAAGCATGGAGCGAAAGACAAAGATG ACTGAAGGAACTTGAGCTAAAACTTTCCAGTTACTTTGTCTTACTCTATACTGTTTCCTAGA CATTTCCCCCCACCCCCCATAGGCCTGTTGCATGCAACTTTGATTCACAGCTTTGCCTTTTT TTTTTTTTTGGGGGNTTNNATTAAAAACNTCαsrGNCCCTTAACCT^ GNAAGGGGGAAAAAATTTNAAATTTGTTTGAAAAAAAAAATTGGNAAAAAAAANNCCCN

AANNGGGAACCCCCNGGAANTTTTAAAAAAAAAAAAAAANNNNGGGGGGGGGGGCCGG NCCCCANTTNCCCCTTTANNGGGGGNNNNTSπS^^ N NNNNNNNNNNNNNNNNNNNNNNNNN^ N NNNNNTSπSINNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNN

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCCGCCGCCCCGCCCGGTGTTACCGGTATTGTAAGAACAAGCCGTACCCAAAGTCTCG

CTTCTGTCGAGGTGTCCCTGATGCTAAGATTCGCATCTTTGACTTGGGGCGTAAGAAGGCC AAAGTGGATGAGTTCCCACTTTTGGGNCNCATGGGGGCAAGAAGAATATNAAαsrANTTTT CTTTNAAACCCTNGANGNTNGCCGNATTTGGGCCNA(^ANNNCCTNGGGNAAANNTNGG GNNAAAANNGGTTTNA INTTCCAANGNCGGTTCM^CCCTTTCNTTNNATTCCNAπ ANANGNTGNCTTGGGCTNGANCTGATANANTNCAAANAGGNATNCNCNGNGCCTTTGGA

AAGCCCCANGGCACANTGGCCANGGTCCACATTGGCCANGNCATAATGGCCATTCGCACC AAGCTGCAGAACAAGGAACATGTGATTGAAGCCCTTCGCCGGGCCAAGTTCAAGTTCCCT GGCCGCCACAAANATACACATCTCTAAAAAANTGGGGATTTACCAAGTTCAACGCGGATG ANATTTGAGAANATGGNGGGGAGAAAAGCGACTCNTACCNNACAGGTGTGGGGNGANAN ACANATCTATAATNGGGGCCCNGNGGCAAAANGGGGGGNNCCTANACTCTTGAGNANAT

GAGGNNGTGCCCCTCCTTTTTTAATTN(^CACCAAAAAANAAGCCGNTTTTTCTTG AAAAAAAAAAAAAAAAAAAANTNOStNGGGGGGGGGGG(^CCGGGNCCNAAATTTNCCC NTTTTTATNGNNNNGGGNNNNNNTN^ NNNNNNNNNNNNNNNNNNNNNNN^ NNNNNC

GCCTATNTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTG NAGGGANTTCGGCACAGGGGCAGAAGGTTCGCGAGGAGGTGGTTACCGGGGNCAATTCT GTTGACCAGGCCCTGATTNACCCMWAAANAATTOSINGTTTCANCCCTNNCCCGGCTTCC

NTTNTNNCNTTGGAAAAGNANGGGAACCANTGGNTNNNTNTNGCTTTNAACN^

NATGCTTAAGNTTTNGCNNNGGNCNTTTNAAANNCCAATNATTIΗAATGGNGC^

ATGGANTGAACNNCCANAATGGAGAAAAATGGGANNNTNNNGGAGAGAATGGNCCNAA GANNAACNNGCCTGTCTTGGAAATGGAAAANGAGAAANTCNAGTGTGATCCTCATGAGG

CCαSlNTGCTATGACAATGNGAAGACTTAOSfCCNNTGNGAGAANACTGNNACAAAAGANT

ATNTNTNGGCCMSINTTGCTCCTGCNCATGCTCTGNAGGCNACNGGGGCTGTNGCTNTGAC

ACCTGTCGCAGACCTGNGGCTTGACCCCGGAACNAAAGGTTCACTTGTNCACTCTACTACC

AAGTATTTCCCAGAGATCCNTCANAAAACCACACACTNTTGTNACCTGCCNCACNNAAGN CTT(^TTGCCCTTTGGAAGTCCACGCTGNCACAAAAAAATACCCNNGAAGTANTTATTTTC

CCCCCCCAAAAACNAGCGNNGGTTTTTTCCAAGGNCCTTCCNAAACTGGGGGGGNGGTTC

NCAAAACCCCCCTGGTlsπsrGGGGGGGNCTTTTNTTTAAANNCCTTTTT^

ATTTCTTOS[ANCTTTNNNTTNAACTTNNNAANNTTT^ G_{GGTTTTAAAAATTTTTTTTCNTΓCATNGGGGNGG}

GCCTATNTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTG NAGGGANTTCGGCACAGGGGCAGAAGGTTCGCGAGGAGGTGGTTACCGGGGNCAATTCT GTTGACCAGGCCCTGATTNACCαS^^π^AAANAATTCNNGTTTCANCCCTNNCCCGGCJ[ CC NTTNTNN<^TTGGAAAAGNANGGGAACCANTGGNTNN^

NATGCTTAAGNTTTNGOvINNGGNCNTTTNAAANNCCAATNATTTNAATGGNGCCNT^ ATGGANTGAACNNCCANAATGGAGAAAAATGGGANNNTNNNGGAGAGAATGGNCCNAA GANNAACNNGCCTGTCTTGGAAATGGAAAANGAGAAANTCNAGTGTGATCCTCATGAGG CCCNNTGCTATGACAATGNGAAGACTTACNCCNNTGNGAGAANACTGNNACAAAAGANT ATNTNTNGGCCNNNTTGCTCCTGCNCATGCTCTGNAGGCNACNGGGGCTGTNGCTNTGAC

ACCTGTCGCAGACCTGNGGCTTGACCCCGGAACNAAAGGTTCACTTGTNCACTCTACTACC AAGTATTTCCCAGAGATCCNTCANAAAACCACACACTNTTGTNACCTGCCNCACNNAAGN CTT(^TTGCCCTTTGGAAGTCCACGCTGNCACAAAAAAATACCCNNGAAGTANTTATTTTC CCCCCCCAAAAACNAGCGNNGGTTTTTTCCAAGGNCCTTCCNAAACTGGGGGGGNGGTTC NCAAAACCCCCCTGGTNNGGGGGGGNCTTTTNTTTAAANNCCTTTTTTT(^TGGGAGGAA

ATTTCTTCNANCTTTNM fTTNAACTTNNNAANNTTTTTTCA^

TTNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGGCTGCGAGTACCTCATGGAGCTGATGACGCCAGCTGCCTGCCCAGAGCCCCC GCCTGAATACCCAGTGGAGGGCGACCATGATGAGCTCTAGCCCTGCCCTGCCCTGCCCAG TGCAGAGAAATCAAGATGTGGAACCAGCCCCCAGTGGTGCTCCCCATCCGCCCCTGAGTC TGTGGACCAAGGCCTGCCGNTATGGGTCACCTCACCCACCCCACAGGGCAGGAAGCAGGT AGGGCTCCATGCCCTGCTTTTGGTTGGCCAGTGGGGCAGAGCCATGTTCCCAGGCCCCTGC

TGCCTCCACAGATGGAATAAAGGAGCCTGTCCTGCTTGGGCCCCCACACCCTGGGGGCCT GGCCCGCTGTGCCCCCCACCCAGGGTATCTGCCTTCCCTCTAGGTGGGGAAGTGACTTGAC CTGTGACCCCCAAACAATAAACATGATCCCTCCAAAAAAAAAAAAAAAAAAACNTGNGG GGGGGCCCGGGNCCCNATTTCGCCTTATGGGGNGCTNNTANAAANNNNNNNNNNNNNNN NNNNNNNNTSINNNNNNNTSINNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNTSINNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNISINN^ NNNNNNNNNNNNNTSπSEN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNTSINNNNNNNNNNNNNN

TNNANAAAACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGGGCGGCCGGGGCCACTTCCTGTGCTTCGTCTACCCGCTGGATTTCGCCCGAACCC

GCCTGGCGGCCGACGTGGGCAAGTCGGGCAGTGAGCGCGAGTTCAGGGGCCTGGGAGAT TGTCTGGTGAAGATCACCAAGTCCGACGGCATCCGCGGGCTGTACCAGGGCTTCAACATG TCGGTGCAGGGCATCATCATCTACCGCGCCGNCTACTTCAGGCATCTACTACACCGACNA GGGCATGCTCCCNGACCCCAATAACACTCACATAGTGGTGAGCTGGATGATCGCGCAGAC CGTGACGGCCGTGGCGGGCGTGGTCTCCTACCCCTTCGACACCGTGCGGCGGCGCATGAT GATGCAGTCGGGGCGCAAAGGAGCCGACATCATGTACAAGGGCACCGTGGACTGCTGGC GGAAGATCTTCAAGGACGAGGGCGGCAAGGCCTTNTTCAAGGGCGCCTGGTCCAACGTTC TGCGCGGCATGGGCCGGCGCCTTCGTGCTGGTCCTNTACNACNAGCTCAANAAGGTCATN TAGGCGCCCCGTCCGCCCGCCGGGAACGGCTAACGCCATNCCTTATTGGGACGGACCACC

GACTTCNAAAAATTCAACGTCCCCGCCGGGGCCGGGCCACCCCGGCCGNGGGGNTTNTTT GNNGGGGGACCATTGGNCCTGGGTCCNCCCCTTTAATTGGGGGGGGGGGNAAAGGCAAT CGGGGGGGGTNTCCTTGGGTNCCCAAGTNNAGGGAANTTCCCNNAACCCAAACTTAAAAT TCCGGGGGCTTTTGAGGNACCCAACCCGGGNTTTAAATTTTTTTTTT^ GNTCCATTTGGACTTTAAAACCCTNTTCCTTTTTTTTTTGCCAT

TTNNNNANANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCTGCTGCCTGCCTGCCTGCCACTGAGGGTTCCCAGCA

CCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCA ACAGGAAGCCTTGCCTGATGAGACAGAAGTGGTGGAAGAAACCGTGGCCGAGGTGGCCG AGGTACCCGTGGGAGCCAACCCCGTCCAGGTGGAAGTAGGAGAATTCGATGATGGTGCCG AGGAAACCGAGGAGGAGGTGGTGGCCGAGAACCCCTGCCAGAACCACCACTGCAAACAC GGCAAGGTGTGTGAACTGGACGAGAACAACACCCCCATGTGTGTGTGCCAGGACCCCACC

AGCTGCCCTGCCCCCATCGGCGAGTTTGAGAAGGTGTGCAGCAACGACAACAAGACCTTC GACTCTTCCTGCCACTTCTTTGCCACCAAGTGTACACTGGAGGGCACCAAGAAGGGCCAC AAACTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCCTGCCTGGACTNCGAGC TGACTGAATTCCCCTTGCGCATGCNGGACTGGCTTAAAAACGTCCTGGTCACGCTGTACGA GANGGACGAGGACAACAACCTTCTGACCGANAAACAANAAGCTTNGAGTGAAAAAAAAT

CCACGAAAAATGAAAAACCGCCTGGANGGTTGGCGAACCATTCTTGNGGAAATTGGTGGG CCCCGGANCTTTNAAAAAAAAATTACCAACATGGTCCATTTTTTCCTTGGGCCCCTNGGAA GTTNGGGGCGANTTTGGATCAANCNCCCCCCNTTTGNNGGGGTNCCTTTTΓTTAAAACCCG GGGNTGGGCCCCCAATTNGGGCNCCCCCCNTTTTTTCCCCANGGGAAACCCTGGCNCCCC CCCCCOTTTTT

TNNNGNNANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCAGCAGCCTAAATGTGCAGACTTTGTAACCAAGCCCACCCGAGATCGGTCTGTG CTTTCACGTGACCACCATCTGTGCCTCCCTCGCTCCATCCAAATTTGTGTAGGCAGCTCCTT

GGAGCCATTCCTAAAAATATAGCTACACCAGGCCCTGGAAACTGTAGTCAAGTAACAGGC TTAAGTGTTTTCCCTCCTTGAGTTAAACCTCCATTAGATCTCTTTTGAGGGACCTTTCAGCT GCAGGCATCAGTGTGTTCTGACAGCGAGACACGTTATGTGTGTGTTTTCTATCTGGATCCA GGGCATCAGGATACAGTTCATCTTCTTGTACTTCCTCTCTGGCATGCAGTATTTCTGGACTA TGTTTATAAGTCTGTTTAGTAAAGGGTGGGATAGAGGATACCAAGGGAGTTTCCAAGGGA

CAGAGATGGATCAGTTAACGATAGTCAGAAATGAACTTAAAAGTTGCCTTGAAAAACCAA TCACATCTTATCAGGACGCATACCTTTATGTTTTCTAGCTCCTGTCGCTGAACTGTTGCTGG GTAGCCCGTACATTTCTATAAATCCTGCTGGACTCAATTCTTACTGNACTTCCAAANAACT CGATCGGGGGGTTTACATGGTNCATGTATTCANGGGAAGNGTACCNAAANGGNNGGATG GGCCCCATTATTTTGGCCTGGGNAAAAGAAACCCNGGGAAGGGGTT(^TTTNAAATNGGG

CAAAAATTTTTTTTTAATC(^AAANAAAATAAACCCCCTTTTGNAAAAAAT^ GGNCCTTTGGGGGGGCNGGGGGTTTTTTTTNTTTTTGGC(^ NTAAAAAAAACCAAAGGGGTTTTTTTTACAT

GNCCCTTTTANGTGNGGTCNNANTNANGNGGGGNATNTTCTCTTTT AN(^TCTCGTNTT TCNCCTCGGNTCTCGCNTCNTCNACTCCCNCATCNATATGTNNACTTGTTAACCCNNNTGA CGCNCGNGGCGTGNTNCCTGNGGGGGCNNNTATAGNGGTGNTCTTCTATTGNTNANNTNT

NTNCGAANATCTTNTGGGNTTNNGGACCANTNAAAGANNTNNTNCTNTAAGCNCCNANTN CCNGNTCNTNNNTAGNNAANANNACNNNTATC^TGCTNGCNATGCTCGNAACNNCTNNN

NNTTTNNATGNNGTNNTAANTNTNNCNGNNNNNGNAGTTGNANAT^ NAAAGTGNTGAGCGGNATNGGGATTGTTGNNNNNACCTTO^ ANAGNTNGNCAGTANNNTGGANTNGNGGNNNNNCAJSΓΓNNGCACNGTTGGCNAGNGNTGG GNAGTNNTNTGTNANNANTNNTTNTNTTCGCGNCAANNNOSFNCGGNTT(^ ACTNTCTCAGNCNC^CAGANTGNNGNTNATGNTTNNGNNNNANCAGTNCAGNCTGNANG CNTANGNTAAATANNGACGNAGTCGTAATCACNGGGNCTACNGNGNGGANCCNNANNAN NGTNTNNGGNTNNTCTNNt^GNGTTNCNGA

GAGGGAGTATGNNNTGGNTAATNTTAGNANGCCTTGTNGNTNGNC(^AGNTCTATTNN]SIN NTNGGNGGTGGGNANNCTANCANNCNNNGGACNGANTNNAAGGAANAGNGGNNGNGGT

NTNNTGNGNNNrø lSπSfTTTGGAGGGGCCGGGTGGGGGCGNTAGNNNGCNGNANAATNTT NGCNGGGNTNGNTAGNNAANGNNCNNNTCNCCTGCNACAGNNGNTNGGNNGGANGNGA NNCNAANGACNNATNNAGCNAGNCCNNGNNAANTNGGCGCAGNANNTNNNCTNNNAGG CNNGGNNGTGNGNTGTAGTNCTGNNNCNNNCCAGAGNACNGANNTGCAGCGNANGTGNT NAGGANNNCGGAANCNGNNNAATNAGNACCGGTNCANNTAAGCANTNCNTNNNANTNN

AGACGTG(^TTGATAGNNCNNTGCNGCNCAGNGCNGCGANNTAATATNNGANCATAGCG GANCCTCGTATCTNTAGNNAGCTGNANGANTACCTCGNNNCNGAGNTCNANCNTGTGANN NANGGAGAGACANAGCGNGGNNNAGANATGNNNNNTNGTNTGTNCGACTGAGNTGNNTN ATNTANAGAGGTGCGNCG

GNCCCTTTTANGTGNGGTCNNANTNANGNGGGGNATNTTCTCTTTTTNANCNTCTCGTNTT TCNCCTCGGNTCTCGCNTCNTCNACTCCCNCATCNATATGTNNACTTGTTAACCCNNNTGA CGCNCGNGGCGTGNTNCCTGNGGGGGCNNNTATAGNGGTGNTCTTCTATTGNTNANNTNT

NTNCGAANATCTTNTGGGNTTNNGGACCANT^^

CCNGNTCNT^JNNTAGNNAANANNACNNNTAT(^TGCTNG(-^ATGCTCGNAACNNCT^JNN NNTTTNINATGNNGTNNTAANTNTNNCNGNNNNNGNAGTTGNANATNTT^ NAAAGTGNTGAGCGGNATNGGGATTGTTGNNNNNACCTTNTTNANNANNTCNCNTNTαsrG ANAGNTNGNCAGTANNNTGGANTNGNGGNNNNNCANTNNGCACNGTTGGCNAGNGNTGG

GNAGTNNTNTGTNANNANTNNTTNTNTTCGCGNCAANNNCMNCGGNTTCNCNAAGTAAAN ACTNTCTCAGNC^CNCAGANTGNNGNTNATGNTTNNGNNNNANCAGTNCAGNCTGNANG CNTANGNTAAATANNGACGNAGTCGTAATCACNGGGNCTACNGNGNGGANCCNNANNAN NGTNTNNGGNTNNTCTNNOSfGNGTTN(_^GAAGCCNNNNGNTNN GAGGGAGTATGNNNTGGNTAATNTTAGNANGCCTTGTNGNTNGNCCNAGNTCTATTNNNN

NTNGGNGGTGGGNANNCTANCANNCNNNGGACNGANTNNAAGGAANAGNGGNNGNGGT NTNNTGNGNNNNNNNNTTTGGAGGGGCCGGGTGGGGGCGNTAGNNNGCNGNANAATNTT NGCNGGGNTNGNTAGNNAANGNNOSINNTCNCCTGCNACAGNNGNTNGGNNGGANGNGA NN(-^AANGACMNATNNAGCNAGNCCNNGNNAANTNGGCGCAGNANNTNNNCTNNNAGG CNNGGNNGTGNGNTGTAGTNCTGNNNCNNNCCAGAGNACNGANNTGCAGCGNANGTGNT

NAGGANNNCGGAAN(^GNNNAATNAGNACCGGTNCANNTAAGCANTNCNTNNNANTNN AGACGTGCNTTGATAGNNCNNTGCNGCNCAGNGCNGCGANNTAATATNNGANCATAGCG GANCCTCGTATCTNTAGNNAGCTGNANGANTACCTCGNNNCNGAGNTCNANCNTGTGANN NANGGAGAGACANAGCGNGGNNNAGANATGNNNNNTNGTNTGTNCGACTGAGNTGNNTN ATNTANAGAGGTGCGNCG

TTGAGNCCNANTAGGGGGGNCGCATNNCNGGGGGGCGGCTCGCTCTTAGACCTAGTGGG ATTCCCCCGGNNCTNGCAGGGANTTTNTGGTNAATNTGANNGAGNTNTTCATNCATNTTT ANCNCNATTCCCNAATATNANAAANCANNGGGGGCCATNCCNNTNTNANNANNTGGGNT

CNTGANAACCTAATT lNTNGCGANNNTCTNATCTTTANNNNNAGGNNNNTGANTNGGATG NAGGNANNANCANATNA^πsrTAGTCANAGAANCTNTATGATTCANCGATAT^WATTNACG TTACTGCGCGNNTANCNNTGNNNNNNTNANATNAGACNAGAANANNGANATNGACANGN NATNNCTNCTGTOWAATCNTTCATANNNNNNNCATGANTANCTTAGTANACGNTGCTNN NNNTNNGCNNGTGTNNTNNCTCCCTTTCT^

NGGTNNNTNNCNGTGANTAATCTGATNNTNACCCNGTGANNNGNGACGACNCNNGACAG NGNTNNCTAGNGTGNTANNCGANNNGNNNTNGNNCNCTNATNNNCNNCCGNGTANAAGA TGTA WCTTTCTNCATNGANCTGNNNNNCGANGNNNNNTGCNTAAGTNGNTTCAACTTAT NTGNGNATNNTNTNANNCTNCNGTAGTCCCNATGATAATATNTNGTATNNTGTGTNACTC TGGANCNCrøWCNGTGGATNTANTTATCNATNAATTNTCCGAANGNNNNTGNGGATNNN

NTNCANTNNCGTTNA(^CNGTNTGATNTNA

ANAGANNCTNATNNAAOSfNGAANNANTNGNTGNNGATTNANCNATNAGTCNTCTCTGAG NANGATNNNTTNNNTOs NNAANATNACNATATNGNNTNNGCGNGCTN TTGGGTOSITTTNNNANNANCGNNNCT(-MSfTTNCTCGNGGNGACGNNGNGGCGGGN^ AGTANNANGNCNNANNO ΠSΓNTGTCCN^

ANNTGAAGTCTACCNTNNNI NNNATCGANNTCGATGTGTANTNNAAGTNNTGTATTNNTC ANCANCAGNNCAC^TGGTNANNGANNTAGANGATGNTCTTCCATNNGATAANCATTTNG NGACGNACCM GAGAGTATGNNTAANNATCNNANNCTGTNANGANGACGNANGTACNNT NNGTGGTATGAGGNCNGAGGACNGANGGAANAAAGNTAGAANCNATGGAGGTTCGACGT

NCGNACNNACGACGNNANNTCNTACNGNTAGGTANTNTCGNCNGAANGNNTCTCCNGTC NCNNGNATCNTCGTNANGTNTGNACGNCGNGAAGCGANGNGATNNATNACNNGNANNAA CGNAACTTAANNNNCGAACGTACGAANGGGACGTACGGNCNCACGCGAATGAANGTAGG TGACTCACGNCNCGCGNTNNTANNNGANNTNTNGNATAGGNCGCNCTGNNNNNTACNCN ACGTCGNACGGGAANGANAGNAATGNCNGAACGNTTACGCG

NAAAAGCTGGAGCTCCACCGCGNGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGACCAATGACAAAGATAGGAATACAAAGTGTATTAGTTAGCC ATCATTCTTGCACTAAGCACCAGAAGACTTGAAAAATCTAAAAAACAAAAAAAAAATCTC

ATTNAACTAGGATAATTCAAAAGGAATATTAAATCGATAAAACCAGGACTCACATGCCAA AGTTCTCATCAGNGGACGCTCACATNTTGGTTCCTTCCATATAAAACTTGGTTGCCGNTNT ATTTAAAGNCTTTTTTTCAAANATTTTCATTGNGTTTCTGNTAAAN^ NNGCCTSINTACNAAACANGGGACAATTCTTANACTGGCTTGAAAATCCCCCCGGNANAANC ATGNGCNACTNTGNAANANTTTTTGNTCAAAAACATTACTGNCTGAAGCAACNTTCCTTTC

TATTTCTTANTGNTACNAAGGACCNGCAGGGANAAATGNCCTNTCCCCANCAGNGAATAC TGGTATGCAATTTACACTTGATGCTCAGGCCTGCTGAAGCTGAGGCTTACCTGTAATCATA NCCTTCCAGGGGATGAANTCTTCAGTTCGTCTAATAAGTNCCCTAACGAGTGTGAAAGGC ACTTTGAGGGGATTTTATTAACAAAAACTTGGTTCT^ CCNCATACTATAAAGCCNNCTGNGACCTACCTACCTCTCAAAANGGACCTTTTTGGGGAA

AAAAGCTNACATTTTTTAGGGGAAAAAAGGATCCCCTTTTTACCCGGGGGGTTAAGATTTT TTTGGNATTGGGGGNCCATAANANCANGTTTTTTTTCAATGNTATTTTACCAGGGAAAATC NTTTGGAATNANAACCTTTTACCCCCCGACCCAAAA

GCCTATCTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCTGAGGAACCCCGGTGGCAGGGCAAGGTTCGGGATCATGAGTTGGATTCCTTTCAA GATTGGNCAGCCCAANAANCAGATTGTCCCCAAANCAGTGGANAGAGANTTTGANCGAN AGTTTGGAAAANTCCANCAGTTGGAGNACCAAACCAAAAGGNTGCAAAAGGNCTTNAAA A AAN(^CGGNCCCCNNCCTGGCCNTGTTTAANTNNGNTG^ΠSRAAAATNTΑSITNGNNNTNG

NTNTCCANCCCCNTTTGCAANNAAAACCAGNANTTTTTNANO^TGGNNANNGCCTTGNNC NCAGCCNTNAANNGGNNGGNTNCNTTCACCCAGGAAAAGGTGACCCAAATCCANAGAAN TGTNATNGANCCTTNAAAAAAGTTCGGCATGTGTGTTCCCNANTCTAAATTGGCATGANA ACCGGNGGAGCCAGGCNTTGCAGNANTACAAAAGGGTGTGNACNCCAGGGTGGAAANNN CCAAGGANAGGGAAAACACGGCCCNGGCTCTGGCCAANNTCCACCAGGCCCGAAAAGAT

TTACGCCATTTCGGATANGNNTTTGGGGCCAAAAAACACGCATTNTTGNGTNNGANANCC GCNNTTATACANACCGAGTGTGGTATTTTTNCACCCCATTTΓTGGTNCNTTTTANNANAAC

NTTTTTCACCCACCCNCTTTNTCTCTTTGAANAACCTNNGGGGAGGCGNNAAAAAACGGA GGCCCAGTTTTNNAANANATCTTasπsrAACCNO^TTTTTCNTTGNTGGGNAN^

NCCCCTCCCGGTNGGNAAAANTCTTGTTGANAANAAAACNACCOSINCCTTCCTTTNTGCC CCTCTTTTTAAAA

GCCTATCTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGCTGAGGAACCCCGGTGGCAGGGCAAGGTTCGGGATCATGAGTTGGATTCCTTTCAA GATTGGNCAGCCCAANAANCAGATTGTCCCCAAANCAGTGGANAGAGANTTTGANCGAN AGTTTGGAAAANTCCANCAGTTGGAGNACCAAACCAAAAGGNTGCAAAAGGNCTTNAAA AAAANCNCGGNCCCCNNCCTGGC(^TGTTTAANTNNGNTGNNAAAATNTaSfTNGNNNT^ NTNTCCANCCCOSITTTGCAANNAAAACC^^

NCAGCCNTNAANNGGNNGGNTNCNTTCACCCAGGAAAAGGTGACCCAAATCCANAGAAN TGTNATNGANCCTTNAAAAAAGTTCGGCATGTGTGTTCCCNANTCTAAATTGGCATGANA ACCGGNGGAGCCAGGCNTTGCAGNANTACAAAAGGGTGTGNACNCCAGGGTGGAAANNN CCAAGGANAGGGAAAACACGGCCCNGGCTCTGGCCAANNTCCACCAGGCCCGAAAAGAT TTACGCCATTTCGGATANGNNTTTGGGGCCAAAAAACACGCATTNTTGNGTNNGANANCC. GOSINTTATACANACCGAGTGTGGTATTTTTNCACCCCATTTTTGGTNCNTT^

NTTTTTCACCCACCCNCTTTNTCTCTTTGAANAACCTNNGGGGAGGCGNNAAAAAACGGA GGCCCAGTTirNNAANANATCTTOW^

NCCCCTCCCGGTNGGNAAAANTCTTGTTGANAANAAAAO^ACCCNNCCTTCCTTTNTGCC CCTCTTTTTAAAA

TTNNNNAAAAGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGTTCCTGTTAACTCTTAATAAACTTACACATGCAAGCATCTACACCCCAGNG AGAATGCCCTCTAGGTTATTAAAACTAAGAGGAGCTGGCATCAAGCACACACCCTGTAGC TCACGACGCCTTGCTTAACCACACCCCCACGGGAAACAGCAGTGACAAAAATTAAGCCAT AAACGAAAGTTTGACTAAGTTATATTAATTAGGGTTGGTAAATCTCGTGCCAGCCACCGC GGTCATACGATTAACCCAAGCTAACAGGAGTACGGCGTAAAACGTGTTAAAGCACCATAC

CAAATAGGGTTAAATTCTAACTAAGCTGTAAAAAGCCATGATTAAAATAAAANTAANTGA CGAANGTGACCCTACAATAGCCGACGCACTATAGCTAANACCCAAACTGGGATTAGATAC CCCACTATGCTTAGCCCTAAACACAGATATTTACNTAACCAAANTTNTTCGCCAGAGTACT ACTAGCACCAGCΓΓAAAACTCAANGGACTTGGNGGGGCTTTATATTCCTTTNTAAAGGAG CCTGTTNTATAATCGATAAACCCCCGATAACCCTCCCCAATTTTTGGTTAAAACAGGTATA

TATCCCGGCTNTTTTTAGGAAACCCTTAAAAAAAAAAAAAAAAAACCTGGGGGGGGGGG CCCGGGGNCCCAAATTTCCC<^TTAAGGGGGGGNNNNANNAAN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNTSINNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNN

TNNANCAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCCGTGACAAAATGTGCTCCTGGTCAAAAAGTGCCCGACCATGATCGANNCTC

NCCTTCATGTCAAGACTACCGATGGTTACTTGCTTCGTCTGTTCTGTGTGGGTTTTACTAAA AAGCGCAACAATCANATTCGGAAGACCTCTTACGCCCAGCACCAGCAGGTGCGCCAGATC CGCAAGAAGATGATGGAAATCATGACCCGAGAGGTGCAGACAAATGACTTGAAAGAGGT GGTCAATAAATTGATTCCAGATAGCATTGGAAAAGACATAGAAAAGGCTTGCCAATCTAT TTATCCACTCCATGATGTCTTCGTTAGAAAAGTAAAAATGCTGAAGAAGCCCAAATTTGA

ATTGGGAAAACTCATGGAGCTCATGGTGAAGGTAGTAGTTCTGGAAAAGCTCTGGGGATG AGACAGGGTGCTAAAGTTGAACGAGCTGATGGATACCAGCCACCATCCAAGAATCGGTTT AAAATGCANACTCTTAATGGGGACAAATAAAANATCTTATTTGNGGTNNN MNANNNNN NNNNNNNNNNNNNINNNNNNNNNNNN^ TNNGGGGGGGGGGGGGGGCCCCCCC(^TTTTTTTTπGGGGGGG

NNNNNNNNNNNNl^MNNNNNNNNNN^ NNNNNNTSπsfNNNNNTSfNNTSINNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNIS^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NN

TNNAGCCCTATCNGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTOSINNGCNAGGNTNAGNNNTANGNTGNTGGGGGGGNTNNNTGNGTGG

NGGACNGGGGNGGGNATANNANNNNCNNTTNTNGANCOSπ^GNGCTTGNCTGCATCTNCN GCNCNGGAGATGAAOSINTATTTACAATGNCTTAGATTNNNNNNNTGTNNTTCTANT^ NNNNGCCTGNANCNGNANANGTNNGANGCNTNNNNCAATGTGNAGCAGGACCATGATAC NACAGGCTTGGANATGGAAGGTTTGTNAANTCNNTNTTANCCATGTGAGC^GGCNTTGGA CNNCNTAGNATNAANAAGTCGNATGNAGTAACCNNGNCGNAATGCTGNGGGACCTGAAC

CNNTCATACTGACTGTGCTTANNAGNNGNGNTCNATGATNCNGGCNTCNANNCCCCCCCC NAGCATGGNNNCNCCCTANANNNANGTACCANGCTTGNNANATCTNNNCATANCGCCGA CCGGANCNTATTCACTCCNNAACAGATGGATNCATNNNNTTAANCGCTGTNGGCCGGNNT GNCTGANAGTC(^AACNCNAACCTTNGAACNTNGAACTTNCTGGCAGGNGAATAANNTTA CCTNGTCCCATNTTGANNANGGAATGATCAGATTAAANACCTGNAAGTGGGNGAAAAAA

ATGACTANTAANGGGGACCCCCCCNCCTGAATCNCGAATGAATTTGTGCACTTGGGCGGG

AAGAAACTCANCATGGNTTCCTNAATCNTAGNCCNCCNCCGCTTGAAAGAAAAACTTGGN

ATTGGGGNAAGGGACTTCANNCTTTTCNGGNNNAAAAATNTTCCTTNATGNAACCTTGNN

GGTATTTGTTANGAAAAANAAAAAAAAAATTTNNAANGGGGGGNCσsrGAANTTGNANTT

T

TTNAGNCCTTNTNNNGGGGNNGNTTNGCAGGNGGCGGCCGCTCTAGAACTAGTGGATCCC CCGGGCTGCAGGCAGNATCCTANATGTGCTNACTTTGAAACCAAGCCCANCCGAGATCNN

TCTGGACTGGATTNGANTGAAAACTGGCNATAAAATCCGGTACAACTCACGGGAGACGAC ATTGGAGAAGAACCAAGCTGGGTCTATANGAAGCAGGCTGGGTCTATGAGAAGTGGNCTT AACATGCAAACCACTTTTTTAAGNAGCCNNATTACAATGAANACATCACTACTGTAATGC TTGNNCCATGATGTNANTTGCTNANTATCAGACTGAGACCCANCNATAAATATANANCGT TGNAAAAANAAAAAAAAANACCTGGGGGGGGGANNATGCCCTNATTTACCNCTGGCATG

CAGTATTTCTGGACTCTGTCTCTAAGGTGGTCCTGNAGAACANGGATNTCCACGTTGACTT GTNCTTGNNGCCGGGNTGNCGNCCTGCANGTAGGCCTTTNGNATCTNGNTNACCTTNGTG ACTAAGAGANCAAGAATTNTCATTTNGCGTTATTNGGACCCTTTNTAANCTATTTAAAGCT NNTTGGGATAANNAATCCTCAATTTTTTNAAANTTGGNCCAGNTNNTNTNCAATGGTCAG GGAATCNTTTCNNTNGTNGCTGGAANNACTTTCTTTTNAATGGGNGNTAANAAAGTNNAN

GCNANTGGNNTCNNTTTTCANANTTNANGTNNANANNCCTNGTCTATCTTNTNT1TTCCCC GTCCCTGGTN(-^GTCTANCCCCOSINNTGCCTTCCTNNATGTCTGGNAAANACCTAGANTTT CNCTTTTTTTATAAATCTTACTNGCCTTTTTTTTGGNGGT^ GTTCTGGGNNCTNTCTNNACCCNANNNCACACACNNAATTCTNGTGCCTTTTTT^ GNATNNTNNGTANTTTTCNTCCATNTTNCCNAGATATCTNNNAGNCTTAN^

C

GCCTATNNGGAGNNGCATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCTGACAATGACATCGGAGCTGTCTCAACGACAGGGCACGGT

GAGAGCATCCTGAAGGTGAATCTGGCCAGACTCGCGCTCTTCCACGTTGAACAGGGAAAA TCACTAGAAGAAGCTGCCAACGCATCACTGGGTCATATGAAGTCAAAGGTCAAGGGCGTA GGTGGTATCATCATGGTCAACAAAGCAGGAGAGTGGGCGGTGAAGTGGACCTCCACATCC ATGCCCTGGGCAGCGGCAAAGGATGGCAAGCTGCACTCGGGAATTGACTTCGGCGACACG AGCATCATTGACCTGTCCTAAACCCCCAGAAGCTGTATTCTAGAAACTAGCTTGGAGGTG

ACGCACGGTCTCCTGGCGTGGAGACTTAGCTTCATCAATTAGATCTAGAAATAGAAAAAT TCTGCAGCCTGTCACTCGTTTTGTTGCCTTGATCAGTGTCTGGTTGGGGGCGGGTTCCAAA GTGTGTGAGAAATGCCCATGTTAAGATAAAAATAAGACCAGTGAAGATGACCAACTCCAC GGAGCCTCCCTTATGAATAGTCCCCATTGTCTGAGATTAGAAAGAAGAAACAGCAAGATC TTAACAGTAAAGAAAGGGCCTCGATGCAGGGAACGGTTTTGGAGTTGGGGGACCTACAGC

AGTAACAGAAGCTTGTAGGTTCAAGGGTGTTGGGGGGTTCGGAAGAAAAAGGCTCTGGG GCANGACCCAGTGCANGGCACAACAAGGCAGGAAGGACCNAGTGGGACNCGGTGAAAG GGGACNCGGCANNCAGAAGTTAATGGGAACACTGGATGGTGCANAACTCATTTCANAGTC CGGAAGAACNTTTGGCCAAAAGAAACCHNAAAAAACTNGGTTTGNTTAAAAAAGNGAAA ANTTNNTTTGACTTACCAANACAAACNGTTTTCCAAAAGCTTGGA

TTNNNCANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGATNTTGTNGAAGATGAGCGGGTGGCAGCGACAGAGCCAAAATCAAAGCCGG AACCTGAGGAGAGAGTGTTCCAGAAGGAAGTGTNTCTTCNTACNTCACCACACCTGAAAG

CANAGCCTGATCCAGCCACAGAGATGGCAGCTGAGTCACTGCCTTTTCCTTCGGGGCACT GTCCAGCTGGNAGCTGGAAGCCTGGTATGAGGACCTGCAGGAGGTGCTGTCCTCAAATGA AAATCGGGGCACCTGTGTTTCACCCCCTGGAAACANGGAGGAAGAATCAAAAAGCTTCAC CACTCTTGACCCCGCCTCTNTGGCTTGGNTTACTGAGGAGCCNGGACCACCAGAGGTCAC ACACACCTCCCAGAGCCTNTGCTCTCCAGAGTCCAGTCAGANCTCNCTGNCTCAGGAGGA

ANAAGAGGAANACCNGGGAAGACCCAGAACCGGACACAGAGNGGCCAGTCCCCATCTCG GNCTGGCAAGCNNCGCATGAAGGAAAAAGAACAAGAANATGAGAGGANTGTGGCNCAG CTTGCTGAAGAAAATGAACCACTTCAACANGAAATCGAGCCCCTGACCAAGGAAAGTGG AGGCNCTCGCCGACTTTTAATGACCGGATGGTTAATCTGCCCCCAGCATTGAACCGGTTGG GACCCATCTCTTTCATTTTCAGGCCACTTTCTGANCCTTTGGTNGGAAGTTTTTACTGGCCN

CCGTNNCCCNGNGCCCAANTSINCNTACCCCAACCCTTNTTTTTTNTTTAGGNNNGGG AAACCTTAGGGTNCAAAAAAAAAAAAAAAGGNCCCTAACGNGNTNATTTAANANNGGCC CTTTTTTTTTTITT ΓGGCCCCIT^ AAAAAAAAAANAAGNGGGGGGGGGGGGGCCCCCCTTNCCCNNNTTTNNCCNNTTTNRØ

T

CAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGTGCTATAGTGTAAATTGAAAAAAGAATAGGTAATTTGCTTTGTACACACACAAAAAT

GTAATGATGGTGCTAATTTCCTGGTAAAAATAAGCACTGCCAAGGGTTGAAGGACTGGTG ACTTGAGAAACCTANAATCCTGTTTGGGAGGAAGANATCTCATGTCTTAATTTCCTCGAGG TTCTGNTAGGANAAGGNAGAGCCTTGGTGAGTCCTGCACCCGACCCTGGGGNGATCCNNT GCNNTCCAAAAGCNGAATACNCNCTNNGNGOSINANGAAGGAATTCTTTGANTTTCTNAAG GCTGGTGNTACCTTGNCCACANCCTNCGTCCACACTGGCTGAACAGGNTGGTANAAANCN

CCANGNGNGGGANCTNCCTTANATACCTTNTGCCCCACTNCCTTTTNACTNTTCTGGGANC ACCTCTATTGGTTATGAAGACTAAGGATATTATTTCTTAAGGAAGTGGAAAGAGTTTATTT TAATTAAAAATCCACAGCCTGGGCAGAAACATTTCCTATCAACATAAGCCCAAAATAGCA CATGTGGNCCCTTTTCTATAGNTACTTTCCTGTGACTCTCAAAACATNANGCTCTTTNTNG GCTTNANGNNTAACACNTTTGGAAATCCCCCCAAACCTTTNTCAGATANNAAGGTGAGCC

CCCGGGGCACGAAGOSICCAAAATGATTGGGGTCTGGGGGCTTNTAAACACCNCANNGGN GGGGGCAGNAAAAANAAGG(^GNNNTCCANNANNTTNAAAANNCCCCGCCTGCCCCCTG TGGCCCTNTTAGGNGGAAAAAAGTTGAAAAAANNGGGCGAANTNGCCNCCNCCNCCANG AAGCCTCCTTGGAANAAACAACO^TTTTNTTAANNCNTTGGNNNNAAAAAAA

NAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGATTTCCGGCACGGGGTCCAATTANAGTAACACTGGCCAACTTTTGAAATGTNTGNCA GCCCNCGGNTTCTCTTGGGGGNTTTTNAATTACCCCNCCTGGGGTCTTNCNGGTGNANGNN NGGTNAAGGNCCNGGNCTTTTAANGGNNCANCNTTNATNACCCGGGNNGNAAAANCCGA

ANNCNAAAAAGNAGNAGNAGNAGNAGTTAAAαsrNCTTNATNTNTTTNGAAAGCNNTCTN GCCCTNGNANNGGNNGNNAGGGTNCCCNAAAAAAAGNGAANCNTGGTNGTNGTTNACAT TAAAATTANNNTNACCANTACCATTANNATGANTATTANATATTANATATTANANACACA NTTTGNGATAGAGAGAANTTAACANAAAAGCTCCCCGTATAAGANAATNTNGTGCTCAGA TACTCTCCANCACAAAATGCGCACNNAATCNCGCCCNAATGTGGAAGANTCTCAACCCGN

GTGCACCCCAATANAAAGGNGACGANATNTNTTTAAAACANGAGAAANCACCCCGAACA CNNNTANGAMsINATNTCTGTTGTAANACATTTNAGCACAAATGCNGCGCNCNTNTATAAA ANGGTGTNTTCCTTCCCCCCAGTGGTGGGCCCCCGNTTNTCATTTTTTNTTGAAGAAAAAT TTTCCGNATTGACTAGACCAAGAAGGCTNCTTNTNAANTNTTTTNTTANGTTGGGAGGAA AGACTTNTTTTTTAAAAAATAACTTTAAANCCAGCTTTNTTTAAA

ATTTTNTTTTTTTTTAACAACAAGANAAAC^

GGGGNACTNTTCCCTTNCCCCCNTTGGTTNNANGTTGGTNCCACCNTTTCTTTTTGTTCA^ AAANTTTTTNTCCCAANNTGGCCTNTTTTAN

NAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGATTTCCGGCACGGGGTCCAATTANAGTAACACTGGCCAACTTTTGAAATGTNTGNCA GCCCNCGGNTTCTC1TGGGGGNTTTTNAATTACCCCNCCTGGGGTCTTNCNGGTGNANGNN NGGTNAAGGNC<^GGNCTTTTAANGGNNCAN(^TTNATNACCCGGGNNGNAAAANCCGA ANNCNAAAAAGNAGNAGNAGNAGNAGTTAAACNNCTTNATNTNTTTNGAAAGCNNTCTN

GCCCTNGNANNGGNNGNNAGGGTNCC(-^AAAAAAAGNGAANCNTGGTNGTNGTTNACAT TAAAATTANNNTNACCANTACCATTANNATGANTATTANATATTANATATTANANACACA NTTTGNGATAGAGAGAANTTAACANAAAAGCTCCCCGTATAAGANAATNTNGTGCTCAGA TACTCTCCANCACAAAATGCGCACNNAATCNCGCCCNAATGTGGAAGANTCTCAACCCGN GTGCACCCCAATANAAAGGNGACGANATNTNTTTAAAACANGAGAAANCACCCCGAACA

ONINNTANGANNNATNTCTGTTGTAANACAT^

ANGGTGTNTTCCTTCCCCCCAGTGGTGGGCCCCCGNTTNTCATTTTTTNTTGAAGAAAAAT TTTCCGNATTGACTAGACCAAGAAGGCTNCTTNTNAANTNTTTTNTTANGTTGGGAGGAA AGACTTNTTTTTTAAAAAATAACTTTAAANCCAG ATTTTNTTTTTTITTAACAACAAGANAAAαS GGGGNACTNTTCCCTTNCCCC<^TTGGTTNN^ AAANTTTTTNTCCCAANNTGGCCTNTTTTAN

TTNANAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCTCGTGNGAGTGACNTCGNNTNTAAACCCTGCGTGGCA ATCCCTGACNCACCGCCGTGATGCCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTACT TCCTTAAGATCATCCAACTTCTGGATGATTATCCAAAATGCTTCATTGTGGGAGCAGACAA CGTGGGCTCCAAGCAGATGCAGCAGATCCGCATGTCCCTCCGCGGGAAGGCTGTGGTGCT

GATGGGCAANAACACGATGATGCGCAAGGCCATCCGAGGGCATCTGGAAAACAACCCGG CTCTGGAGAAACTGTTGCCTCACATCCGGGGGAATGTGGGCTTCGTGTTCACCANGGAGG ACCTCACTGATATCAGGGACATTGCTGCTGGCCAACAAGGTGCCAGCTGCCGCCCGTGCT GGNGCCATANCGCCGTGTGAAGTCCCTTNNGNCAACACAGAACACTTGGTNTGGGGNCCC GAAAANACCTTCTTTTTCCCNGGTTTTNGGCANTACCA(^AAAAATCTTCANGGGCCCCAA

TTGAAATCCTGAGTGATGTGCAGCTGATTAAGACAGGAGACAANNNNNNNNNNCCNNNN NAANCCCCNCTTGNTGAACAATGCTGAAAAATTTNCCCCCTTTTTCTTTGGGGCTTGGNNA TTCCANCANGGGGTTTGGAAAATGGGNANNATTTTACAANCCCTGAAAGNGCTTTGACAT TACCAAAGGAAAACTNTTGNANTTTCCCCNTTTCTTGGGANGGGCGTNCCNCAAATGTTTN CCCAGCGNGGNGNCCTTGCAAAATTGGGTTACCCCAAACCCGGNGGNATTTTTGGNCCCC

CC^TTTTTNTTAATTNAANGGGGNNCCAAACCCCCGNCCCNGGGTTTTπ NAACTGATTAACNCCCTTTNCCCCTTTGGGTGN

NNCAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGATACTTCTTTTTTTTGAAAAATAATTGACTCTTTTATAAAGTA TCTTTTAAATTAATAATGTGCATAAGTTTGAACAGAGAAAACATTTAATTAAAAATGATAC TGCATCTTCTAAAAGGTTTTTTCAGATACATTTATAGTATATCAAGGGGCTTCCTCACTGG CTCAGCGGTAAAGAATCCACCTGCAATGCAGGAGACATAGAAGACTCAAGTTCAATCCCA GGGTTGGAAAGATCCCCTGGAGTAGGAAGTNCCCACTCTTGACAGGTTCCTCTCTTCCATG

GACAGAGGAGCTTGGCGGGCAGCAGTTCATAGGGTTGCAGAGAGTCAGACACAACTGAG CAGGACCACGAGCATAGTATATTAAACATGCTTTGGCTCATCAACAACCCATGGCCAGTA TGGTAGGCCAACTCTGATTTACAGGAAGATATCAAACTTTCGGCACAAAAGCTTTTTACAG TCTTTAAGNGGTTTTCATTTTCATGTAAAAAATAAGTNGCATTTGATAGTTTATATTGGGG GCTTTTGANCCTTANCTTGCTGGAGTTTGAAATTATTTCCTGACTCATAAGNATAATCTCTN

TTAATATTAANCTATTATTGCTTGAANAACCAAGGTTACAGGTCTTTTCTCAATTTCTTCNA CCTTNGGTNAACCCNCCAAAANGGGANCCAGGGGATTTTGAANGGAAAAAAGGAANCNC TTGTTCTGGTTTTGGGTTAAACCCNTTTITTTGGGAGTTGGTTGCNTTAA NNCCaSlGGGGGCNTTACCTTTAANGGGGANCCCTTTGGNCCCCCCANCCCAAAAAGGAAT GGGNAANGAGNGNTCCCTGGAAAAATAAATTAAAANNANNNNCCCN

TTNAAANNCNATCTGGAGCTCCACCNCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAANAAAAAAAAAAAAAATTTTGGGGGGGGGNCCGGNNCCCNATTTTNCC TGTGGGGGGAGNAATNTANAAGCGGTNCTOSfNNTCCTGNTCCATGNTNTNAANAACNNTC

NNGTCCCNTTGCCTGNACAGGAGGAACCCTTGNNATATNCNCACCCTCCTTTGTCTGNTTA AGCATTANNCTGCTAATAGAGCGGNCTGACCTGTTNATCNAGNGATACATCCTCGCGGTC AGGGATTCTTGGNGCTGGGTTAACGNNCCTGACTGNNTATTGCTGNTGAANCTGCACTAC NATCTNNAGNATCAATANANCNTTNTTGTTACTTTCCACGCTNNCTGGGGGNNANTGGGC CNTTCTCNTGCCTGTACCNCCTAGGGNNGGTAANAACATAAANANTTANAT WTTTCCCTT

GTGGCCTTACTTTCCATAATTTTCCNGGNC<_^CCCTTGGNTTGNTTTGNTTCCCTTCATANT GGCCNTTNGNGCTCCCTTTCCANNCNAGNGNAAAAGAAGGCCNCGNTGNTTAANAAATG ACCCTTTTTNTTCCGGCCANTTTTANCCNGGGGGAAAGGNANTCCNCNCCNNNACCCGGG GNAACNTNTTTTTTCCCAANTAANNNTAAAGNTNNNGGGNAGGTTTCCCCCCTTCCGGT^ GGNCCCGAAATAAAAGGGGGTTNTTTCCAANCCCANGGNAACCCAANCTNGTTGTNCCTT

TCCTNGGNCCCCCCCTGANNGACTNGCTTAAAAANGCNNCCNTNTNTTTTCCCCCCCCCCC CCCCCCCCCCCCCCCCTGGGGAAATNANNTCCCCCCCCCCCCCCCCCCCCCCCNNTTCCNA ANOStTTTCTTTTTANAAANAAAGGNNGGNAGCCNTTTTCCCTTTAATTT^ GACANONNAAAAGGGTTTTTTCTCT^ NNCTNNGGGTTCCCCT

TTNNGCCTATNNGGAGNNGNATNNCAGNGGCGGCCGCTCTAGAACTAAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCTCGTGTGAGTGACATCGTCTTTAAACCCTGCGTGGC AATCCCTGACGCACCGCCGTGATGCCCAGGGAAGACAGGGCGACCTGGAAGTCCAACTAC TTCCTTAAGATCATCCAACTTCTGGATGATTATCCAAAATGCTTCATTGTGGGAGCAGACA ACGTGGGCTCCAAGCAGATGCAGCAGATCCGCATGTCCCTNCGCGGGAAGGCTGTGGTGC TGATGGGCAAGAACACGATGATGCGCAAGGCCATCCGAGGGCATCTGGAAAACAACCCG

GCTCTGGAGAAACTGTTGCCTCACATCCGGGGGAATGTGGGCTTCGTGTTCACCAAGGAG GACCTCACTGAGATCAGGGACATGCTGCTGGCCAACAAGGTGCCAGCTGCCGCCCGTGCT GGTGCCATAGCGCCGTGTGAAGTCACTGTGCCAGCACAGAACACTGGTCTGGGGCCCGAG AAGACCTTCTTCTTNCAGGCTTTAGGCATCACCACGAAGATCTTCAGGGGCACAAATTGA AATCCTGAGTGATGTGCAGCTGATTAAGACAGGAGACAAAGTAGGCGCCAGCCGAAGCC

ACGCTTGNTGAACATTGCTGAACATTTTCCCCTTTTT(^TTNGGCTGGNCATTCCACAAGG NGGTTTGAAAAATGGCAGCANTNTACAACCCTGAANNGCTTNNCNTNNCNAAANGAAAA NNNTTTGNATTTCCCCCTTTCTTGGGNGGGCGTNCCCCAATGGNTTNCCNACCGGGGGNCC CTTCCAAAATTGGGTTANCCCTAAACCCGNGGGGATTTTGGGNCCCCCATTTTTTTTTAT^ NAAANGGGGGNCCAAAAGCCCCGTTNCTTGGGNTTTTTNTTTT

GCCTACTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCACACGCCAGGAGCGCTGGGCTCCAGCCTTCTCACGCAGGTGGCTTCTCAAGGAGCT ACCACCGTGTGTGAGCTCCAGAGTAGGTGCAGATGTTTTCATCACATCTTCCACGTTGTTG

ACACTGTCTTACCTTCTCAAGTTCCCCAAGTTCCCGAGAGCTTTCTCCTCTGCTATGCATTT TGTCTTCACAGCGCAGCTTGCAGTCCCTTGCTAAAGATGATTATAAGCTCTGCATAGTGTT AAGCTTTATTGTGGTTATGTGTATGTTTCTTCTTCC1TTGTTAAGCAGACCCACACCTTTCC AGGTCAAAGTACAGGATAGAGTGCTATCCΓΓCATCTTTACCATTTCTTTTACTCCGTTTAAA GACTTCAGAAGTCTAATCCAGAGTTGAGCCAATTCAGAATTGACTGTAATTGAACACAGG

CTAAAAGTATTTATGGGGGGAGTGACTTTTAGCATGAGTTTTCTGATTTTTGTAGCTGCTA

ACCTTTTAAATCTTTATTTGCAGTTCATGTAACAGTTGTCTTAAATTACATGATAAAGCAGT

CCTGTTCAATTTTTTTTTTAATGTGGCTTGTAGAATTTTTAATAAATGAGCTTANGTCTG TTTTCATGTGGAATGCAGATGGGTGCTATCAAAGCCTCTCCCCCATCACTATAGNGTAATA

TGGTTCTTTCAAAAGNGGTGGCAAATGTACCGANTGGAAACCTGGTTCTTGGNCTGGAAT

ATATAAACCCCTTCCAAANGGGTTNTTTTTGGGGGAGAAAATGGGGGGGGAGATTTTTCN TAAAANAAAGAAGGOSrGGAT(^GGTNATCNTαS[ANTTTTTACTTGGTCCCTTAAATNTTTT TGGGGGGGGATNCCT

TTTAAGCCNATNTGGAGCTCCACCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCC

GGGCTTGNAGGANTTNGGNTCGAGGCTTTTATTGAGACCACCCAAGGACCCCAGGGGACC

CACACCTGGTGTNACGGTATCCGTGGTTCTCAGCCCCANAATGGTGGGCTTGNTTTCCCAG CCCCCTGCTGTCCCCACCAAGGGACAGGCCCNTCTCTGTGCCCTGCCTGGGATGGAGGACT

CGATCATNAAATACNACCTCCTTTAAACATCCANCCCTAGTCNTCCCCANCCCAGAGCCTG AGGGTCATTTGANAGGAAGTGAAAGTGGCNTGCNTCAATGGACAGNACTCANAAANCCC TTTTATAAAGGATATTTAATATCGNGNCCCCAGCTTNGTGGαsrGGTTTCANTTTTCTGGCC AGGNTAAAGTNTGGCTGGGCCTACNCTGCCNTGACATCTCTCTGACTGTTACCACACGAG CTGAGTGCAGTGGANNAATGCGGCCTCTTTTTNTGCCAGGAGNGCAAAAGTGCCAAGCNG

TTGTTCNACACACNANNANATNNCGTNTTNCANANTGTGNGACCACCNACCAACTATGAC ATAACGACWTCTGTAATNTNTNTAAAAAAAATATATTTTGGGNGCTGTCTTGAAAAAAAA AAAAAAAAAAANNTCNTNNGGGGGGGGNN(^CNACCCTCNTTAATTCTGCTTTTNNAGN^ GGNANTTATNTNAAAAATNTNTCTTTNTNACCANTTTTTTANCANNNGTπ

NNNTC<^TCNNTNCNTGNTNNTTNTTATTTCNGAACATANTCATNTTCTTCCTTOSrcπ^ NCATAACNTNTNTN(^CNNNNTTNCTTNTTATTCTNNTTACANTCCTNAAN ANAATTTATNTGNNAANGNTCCCTATNTNTTNNNTANTACNTNTCANATTCCACNTTATTA NATCATNATTTNTCTCTTCCCTCANANNCCTNCCC NAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCCCTCATCTCCGGACCACACTCAGGTTCCTGTTCTTTGGTGCC GAGTCCAGGGGATCCACCTCTGTCTCATCCGTGGCCTCTGCTGGTCCTGCCCAGAGGCCAG

CACTCAGGAGACTCCTGCAGGGGTTGCACCTGGCCCAGGGCACCTGCATTTGCAGATTTA GTTTCCCAATTCTCCTCTTGGTACCAAGTCGCTTCTCCTACATCTGNTTAAANGCTGNATTC ACCTNACGCTGGANCTNTGANCTCACACACTTGCCTCCCGCCCGCCTCCCCCTNCCCAGCG TTTGACCCCGAAAGCCCTCTGAGGCAGANAACAGAAATGCCAGANCACCCGCCTTTTTAT GGGGCACTCTTCANAAAGTCTCTGAGGCCCTGAAAAGAAGAACTACNTNATGGAAACCAT

TTTGCANCCTNCANCACGGGCATTTATCTNAATAATCATTTCATTTAAAATGTGGGTCAAA CATATAAATCATATCTTGAAAGAAAGNATTTTGGTGCCACAGAAATCGCCCTGTGTTCTTA CCACCTAATTTGAAAAATGTGTTTTGAAGTCANGAAAGAAAGCCAAACAAGCCTGNGGCC TGGGGTGTTTTTTCCCCACATG(^CCCTITrCTTTTCNTGTGTNGCCCAAAAA CCGCTCCTGNGCCAAAAGGNNGCGGGGGAGNNCCNCACCCCTGAAGNTAGGNCACCTCTT

CTGCGNATNTTAAAANCTCCCCTCCCTTTNCANAANAAAGGGGGTTGGGGAAACCCCGAA GGGNNGCCGGCNTCCTCAACCTGGTGCCTCATTACCCTNGGGNCCCCNNCCGACCCCCTG GNGACAAGNGGTTTCANTTANNAACCCCNNTNTTTTTNGCCCTTAAAAGCCC

NNNCNNNNCNNNNAOSINNNCCTTNNTTANTNNNNTNN^

CTCANTTCCTTNNNNTNCTTNTNTNTNANNGNNTNGNNATNAGTNGCTAATATCNCTπ AGNANNNCTGGAGCTCCACGCGGTGGCGGCCGCTCTANAACTAGTGGATCCCCCGGGCTG CAGGAATTNCGGCACGNGGTTCAATTAAAGTAACNCTGGCAACTTTGAAAANGNGTGTAC AGCCAACGGNTTCTCTTGNGGGCTTTNNNAATNACACCACCTGTGGTCTTACNGGNTGAA

GTGTGGTTCACGGCCTGTGCATNTCATNGGACCAGCACTTANTANCCGTGNANGAAGATG CAGAGTCNNAANAGGAGGAGGATNGANGANGTGAAACTCCTGAGAATATTTGGAAAGCT GTTCTTGCCCCTGNANATNGGNTGCAAGGTTCCCCACAAATAAANTGAATCTTGCTTGNTT GATGAAANATNAAGATNATGATTGACNATGACNATTGATTGNATGATGATCANANANGA NNTATGATTGACCGATTNCTTGATTGANNNAANNCNTTNAGANTAAATNTTTNCANGTN^

AAAGAAACTCTGTACCCAGAATAC^TCCTANNCNAAAAATNGCACCANNTNATCNGTTTT NATANAATNNNAGNTNACCTCAAAANTACTCGGTNNANNCNCCCANTTNATTCNAAAAA GGGNT<^CNTAANTTCCCTTTCCANTAAANNTCCNNGGGAACAATAAACNNCCCGGNANN TNCCACCTTNAAAAGNNACCCTTANCCTCCTGGNNNTCANNNAC^TTTNAACAGNGCANN ATAAGNTTGGCCNNGCCCATNGGTNATTNCAAAAACNTANAGGGNNGGGTTTTNCCTTTT

TCCCCAAAANTNNNNTTNANTCCNCAANNTNNTTNTTCGNANTCCATTGGNNNTAATNAA ATNTGGNTTNNCCGGNANTNGACCTGGNACCCANGGGAANNGGC^AATTNNANAATAAN CNTTCTAGGCNNAATNGGNAAAGNAAANACCCTTCTTTTAAACAATAAATATTCTCTTT^ AACCAGCNT^αs^GGNAACAAANAANATCTTNCCANTTCTTANATTNCAAATTNTACT }NN NAANCCGANNTCNGNANTNTACTCCNCANNGNGNNCNATTTNTGTCATNACGACCGGCGT

AGGGAGTGCNCTAAATATTNNTTTCCTCGTNACACCCCGTNNNTAGTGAAATAANTANNG TAGTCGGNNCCACACGATCTANCTCTNTNNGCTCCTNTNTAAANANTNTGTGGTCTNACTG TNCTNAACAANCNAGGGTNTGNTCG

NNNCNlSlNNCNNNNAasrNlNNCCTTNNTTANTNN^ CTCANTTCCTTNNNNTNCTTNTNTNTN^

AGNANNNCTGGAGCTCCACGCGGTGGCGGCCGCTCTANAACTAGTGGATCCCCCGGGCTG CAGGAATTNCGGCACGNGGTTCAATTAAAGTAA(^CTGGCAACTTTGAAAANGNGTGTAC AGCCAACGGNTTCTCTTGNGGGCTTTNNNAATNACACCACCTGTGGTCTTACNGGNTGAA

GTGTGGTTCACGGCCTGTGCATNTCATNGGACCAGCACTTANTANCCGTGNANGAAGATG CAGAGTCNNAANAGGAGGAGGATNGANGANGTGAAACTCCTGAGAATATTTGGAAAGCT GTTCTTGCCCCTGNANATNGGNTGCAAGGTTCCCCACAAATAAANTGAATCTTGCTTGNTT GATGAAANATNAAGATNATGATTGACNATGACNATTGATTGNATGATGATCANANANGA NNTATGATTGACCGATTNCTTGATTGANNNAANNCNTTNAGANTAAATNTr CANGTN^

AAAGAAACTCTGTACCCAGAATA(^TCCTANNCNAAAAATNGCACCANNTNATCNGTTTT NATANAATNNNAGNTNACCTCAAAANTACTCGGTNNANNCNCCCANTTNATTCNAAAAA GGGNT<^CNTAANTTCCCTTTCCANTAAANNTCCNNGGGAACAATAAACNNCCCGGNANN TNCCACCTTNAAAAGNNACCCTTANCCTCCTGGNNNTCANNNAC^TTTNAACAGNGCANN ATAAGNTTGGCCNNGCCCATNGGTNATTNCAAAAACNTANAGGGN^ TCCCCAAAANTNNNNTTNANTCCNCAANNTNNTTNTTCGNANTCCATTGGISINNTAATNAA ATNTGGNTTNNCCGGNANTNGACCTGGNACCCANGGGAANNGGCNAATTNNANAATAAN <^TTCTAGGCNNAATNGGNAAAGNAAANACCCTTCTTTTAAACAATAAATATTCTCTTT^ AACCAG(^TT(^GGNAACAAANAANATCTTNCCANTTCTTANATTNCAAATTNTACTNNN

NAANCCGANNTC^GNANTNTACTCOSICANNGNGNNCNATTTNTGTCATNACGACCGGCGT AGGGAGTGCNCTAAATATΓNNTTTCCTCGTNACACCCCGTNNNTAGTGAAATAANTANNG TAGTCGGNNCCACACGATCTANCTCTNTNNGCTCCTNTNTAAANANTNTGTGGTCTNACTG TNCTNAACAANCNAGGGTNTGNTCG

TNNNCAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGGCGAGACGAGCGAGGCAGGAACGTGGACGTCGGGTCTC TCGTTTGCACCGCGAAGACACCTCTNCTGCAANGATGGTCANCGTNCCTAAANCCCGCAG GACTTTNTGTAANANGNGTGGAANGCNTCANCCTCNCAANGNGACCCAGTNTAANANGG

GCAAANATTCCNTGTNTGCCCAGGGAAAGAGGCNCTNTGATCGGAANCAAAGNGGNTNC GGNGGNCAANCCAANCCANTTTTCCGGANGAAGGNTAAANCCACCAANAAGATCGTGCT GANACTTGATTGCGTTGAGCCCACCTGCANATCCAANAGGATGCTGGCCATTAANAGGNG CAGGCTTTTTGAACTTGGAGGANATAANAAGAGAANGGGCCAAGGGATCCAGTTCTAAGC TTΓGGAATCCTTTGGTNCTTANGTTTGGANAANAAAATGTTGAAGTTACAAAAAAAATTG

CCTΒAATGANAATAAATNCCGCGATTTTCCTACTTNNNNNNNAAAAAAAAAAAAAACCTT NGGGGGGGGGCCCGGGCCCCAATTTNCCCNTATAGGGNGNN>JNNT^^

NNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNN NNNNNNNNNNNTSINNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^ NTSπSlNNNNNNNNNNTSlNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

TNNNACAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGGTCCTTCTGGCCCCGCTGGCAAAGACGGTCGNATTGGAC AGCCTGGTGCAGTTGGACCTGCTGGCATTCGTGGCTCTCAGGGTAGCCAAGGTCCTGCTGG CCCTCCTGGTCCCCCTGGCCCTCCTGGACCTCCTGGCCCAAGTGGTGGTGGTTACGAGTTT

GGTTTTGATGGAGACTTCTACAGGGCTGACCAGCCTCGCTCACCAACTTCTCTCAGACCCA AGGATTATGAAGTTGATGCTACTCTGAAATCTCTCAACAACCAGATTGAGACCCTTCTTAC TCCAGAAGGCTCTAGGAAGAACCCAGCTCGCACATGCCGAGACTTGAGACTCAGCCACCC AGAATGGAGCAGTGGTTACTACTGGATTGACCCTAACCAAGGATGTACTATGGATGCTAT CAAAGTATACTGTGATTTCTCTACTGGCGAAACCTGCATCCGGCTCAACCTGAAGACATCC

CAGTCAAGAACTGGTACAGAAATTCCAAGGCCAANAACATGTCTTGGGTANGAAAAACTA TCAACGGNGGTACCCANTTTGAATATAANGTTGAAGGANTACCNCCAAGGAAANGGCTAC NCACTTTGCCTTTATGCGTNTGCTGGGCAACCATGCCTTTTNAAACAGNCNCTTTCCAATT GCANNAACCNNNGTTGNANCCCTNGAANGAAGGAAACTGGCAACCTGGAAAAAGGNTGG CATTTTTGCAAGGGATCCCATGGATGTCCAAACTTTGTGGCCCNNGGGCCAACCAGCANA

ATTNCCNTTACCCTGGTTNTTGGGAAAAGGGGTGGCTTTNAAAAANAAAAAATGGAATGG GCCAAAAAAAAAATTTTTNNNNTTTTNAACC NNCCNNGNCCCCTT

TTNANNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGCTTTGCTGAGGGTCACATTGAGCTCCCAGCGACTTCAGGGGCATCTTTAGG AGTCAGCACTATGGCAGAAGACATCCAGGCCAAAATCAAGAACTACCAGACTGCTCCTTT TGACAGCCGCTTCCCCAACCAGAACCAGACCAGGAACTGCTGGCAGAACTACCTGGACTT CCACCGCTGTGAGAAGGCAATGACCGCTAAAGGAGGTGATGTCTCCGTGTGTGAATGGTA CCGGCGTGTGTACAAGTCCCTCTGCCCCATATCCTGGGTGTCAACTTGGGACGATCGCCGG

GCAGAAGGCACGTTTCCTGGGAAGATCTGAACTGGCTCCATCCCACCTCTTCTGTCCTCCG TCCTTCTCCCCAGGGTGGTGAAGGGGGACCGGGGTACATGGTGATCCCCACCCTGGGATC CTGACTCATGGTATAACTAATAATAAATGCTCGTTGGAAACGTGAAAAAAAAAAAAAAAA AAAANTTNGGGGGGGCC3S[GGGC<^CAAATTCCCCTTNTNNGGGGGTGGTTTAANNNNNN ATNGNNNNCNCHNNGNCCNNNGGNNOSICTTNNNT(^TACTANANTNGN^

GNTNNNNCTNANGNNNNNGNNNN^ ^"

NNNNNNNGNNNNNNrøTT^^

NNACTTGGNTTTNCNNTNNNNNNNNANNNNNTNNNNNTTπ

TANNNCαSlNAAACOSTNGNNNNTTTNCCNTTGNNT^^

NNNC(^GGGGGNNNNGNNNAANTNNTTNNNNNNNCNNNN^

AANNNNNNAANCGGGNNCCOSπsπSINNNGGNNNNNC

TTNNANCCTATNTGGAGCTNCANNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGAATANNGAGAGTGCAGCTGGCATAAGCTGACCCANG AGNGCCACANAACGAATGCTCCTGCCTTCCCATGGAGACTGCATGACCTCATGTNTGTGG AGCGCATTAGGGTCCTTGAGTAAAANGGAAAAAAAAAAAAAAGGTTCCTGNTGCTCTNAT TTNTANNTA<^CNGTNNACTNNNGTGGGNAAACCAN^ GAGTGNGTTTTTTGTTGNTCNACAAAANCNGGANGNTATNNGCTTNCNNCANAANTNGNN

NNNAANGGAANACTATNCTTGNCCTATTATACCTNCANTGAAACNGNGACGGTGNAANTN ATNCCTTTAGGNNTNNACTACACAAACTTGCCNAANNATNNCCTNCTCTGANAAAGGAGG AATTCCNCNGGGATGNTGGANGNANCGNANGNTGGCCACCCCACANTATTTNNGANTAC GNTTNTNATGNGTCNTTCNTTGGTCTNGGAATNTNTCNCTNCCNCCAATTNTGTNGACACA NNNCCATTTCNATGTNNTN(^GTCCTTTTCCCTGCNCTNNTTTGGGTGAGGGGNπ

ANGGGGGCCCTNTGCGGNGGGAGCNCCTTCNCCCCCCCCCCTTGGACAAACTTTTTTTAAA AANGGCNAGGGNGGGCCTTTNTTNTTTTNCCCTTTNACCCNGGGGGGNAATT^ TTTTTCCNGACCNTTNACCNNGGGNNNNTTTGNANAACCNNCCCCCCCCCATAGGAGGGA NAAAANCCNTTTCCCNTTTCCCANCCCTGGNGAAAAATTTTTTTGGGCCCTTTT^ CAAAAATTCCCTTTAAACCAAAAGTTGTTITTTGGNAAACCCTTGANATTGCCCTTTG

NCNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGTGACAΛTGATCTTATAATATTCTTGACCCTTTTTATCATCTTTCAACTAAAAGTTTC AAAACACAACTTTTATCACAATCCAGAACTGACACCAACAAAAATATTAAAACAAAACAC

CCCTTGAGAAACAAAATGAACGAAAATTTATTTACCTCTTTTATTACCCCTGTAATTTTAG GTCTCCCTCTCGTAACCCTTATCGTACTATTCCCAAGCCTACTATTCCCAACATCAAACCG ACTAGTAAGCAATCGCTTTGTAACCCTCCAACAATGAATACTTCAACTTGTATCAAAACAA ATAATGAGTATCCACAATTCTAAAGGACAAACATGAACATTAATATTAATATCTCTGATCC ' TATTTATTGGATCAACAAACCTACTAGGCCTATTACCCCATTCATTCACACCAACAACACA

ACTATCAATAAACCTAGGCATAGCCATCCCCCTGTGAGCAGGAGCCGTAATTACAGGATT CCGCAATAAAACTAAAGCATCACTTGCCCATTTCTTACCACAAGGAACACCCACTCCACTA ATCCCAATACTAGTAATTATTGAAACTATCAGCCTTTTTATTCAACCTATAGCCCTCGCCGT GCGGTTAACAGCTAACATCACTGCAGGGACACCTATTAATTCACCTAATCGGAGGGAGCT ACACTTGCACTAATAAGCATTAGCACTTACAACAGGCTCTAATTACATTCACCATTCTAAT

CCTACTAACAATTCTAGAAGTTTGCAGTAGCTATAATCCCAAGCCTATGTATTCCTCTTCT AAGTCAGGCCTATATCTGNATGGACAACCCCATAATGGCCNCACCCAAACTCATGGCTTA TCATATAGTAAAACCCCAAGCCCCTTGACCTTTTTAAANGGAGCTTTGNCTTGGCCCTTTT TAANAACATCCGGGCCTTAACCATTGGGAANTTCACCT

NCNATTTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGAANTTCGGCNCGAGGTTCCAGATGGCCCGAAGTCCACAGGCAGATTCAGAATCAGCT

GGAAGAAATGCTGAAGTCTTTTCACAACGAGCTGCTCACACAGCTGGAGCAGAAGGTGGA GCTGGACTCCAGGTACCTGAGTGCTGCCCTGAAGAAATACCAGACGGAGCAGAGGAGCA

AAGGTGACGCGCTGGACAAGTGCCAAGCTGAGCTGAAGAAACTCCGCAAAAAGAGCCAA GGGAGCAAAAACCCCCAGAAGTACTCGGACAAGGAGCTGCAGTACATCGATGCCATCGG CAACAAGCAGGGTGAGCTGGAGAGCTACGTGTCCGACGGCTACAAGACCGCCCTCACCGA GGAGAGGCGGAGGTTCTGCTTCCTGGTGGAGAAGCAGTGTGCCGTGGCCAANAACTCCGC CGTCTACCACTCCAAGGGCAAGGAGCTGCTGGCGCAAAAGCTGCCGCTATGGCAGCAGGC

CTGTGCCCGACCCCAACAAGATCCCCGACCGCGCCGTGCANCTTGATGCAGCAGATGGGC AACAGTAACGGCTCCATCCTCCCAGCGGTCTTTCGGCCTTCCAAGTCCAACCTGGTCATCT CAGACCCCATTCCAGGGGCCAAAGCCCCTGCCGGTGCCCCNTGAACTTGGCCCNATTTGT GGGGGCGGNTGTCTGNCCAAGAAAAACCCCCCCCTTATTGAATGGGGGTTTCGGNCCCAA CAGGGGANGACTTACCACCCCTTGGGCTTGACCCGNAGGGCCCCCCCANCCCAAATTCCA NTTCCCCCCCGNTNTTTTNAAAAACANGNTTGGGC^^

GGNANNAAAANNNGGGCCCCNAAAAAAANNTTCCCCCCCNATTGAAAAAAAAAANCTTT CTTTNTTNAACTTCATGGGCCCCGGCCGGAACNCAACT

NNANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCTTCTGTGGAANAANAAAGCTTTGGTCCACAACCTATTTCCCGACTAGANCANTGN GGNATNNATGCCANTGATGNGAAGAAATNGGAAGAANCTGGATTTCATACTGTANAGGC l o TGNTGCCTATGCACCΉAAAAANGANCTACNNAATATTAAGGGGATNAGTNANNCCNNAG

CTGATACAATTCTNACTGAGGCAGCTAAATTAGTNC(^ATGGGTTTNACCACTGCNACTG AGTTNCNCCAAAGGCGATCTGAGATCATACAGATTACTACTGGCTCCAAANAACTTGACA NACTGCTTCAAGGANGAATTGAGACTGGATCCATNACANAGATGTTTGGAGAATTNCGAA CTGGGAAGACCCANATCTGTCATACATTGGCTGGNACANGCCAACTCNCCATTGACCGAC

15 GTGGAGGTGAAGGAAAGGCCACTGTGCATTGNCACCNAAGGTACCTTTAGGCCTGAACGG

CTGCTATCAGTGGCTGAGAGATATGGCCTCTCTGGCAGAGANGTCCNNGATAATGNATCA TATGCCCGANGGNTCTCACAGACCACCNGACCCAGCTCCTTTATCNNGTNNNCTGCNCAN NANGGGTTGAGTGNCAGGGTATTGCACCTGGTTAATTTGTAGANAGGNGCCACTGNACCT CTANAGAAACGNGACTNTTΓTNGGTTNCANGTGAANNTTTTNAACCCANGGCATATTCCA 0 CTTTTGGTCGGGTNTTCTTGTAGGATTGCCTNTTTNGCGAACTTGGGNNGGTNAAATTT^

GNGGGNNNCAAGGNGNGNATCCCCCCACCCCCNGGGGNGNGNCCCCAGAGGNNTGNGNG CAAGCCCTNGTTTGNCTTCCNGANTNCNAAAAAAAACCCTTTTTNGGGGGAAANTATTAA

TTTGTTC 5

NANNNCGANGNNNNNANNTNNNATANATTNNANANANNANNNTNTNNN^ CNTCTNTCTNTNNATATGGNATTCTTANGCANCTCNATATNGGAGNGNGGANCGAGGNAA CATCTCTNTTTGAGNCCTCNAGNGAGTNGNATTACAGTNGNNNTNCTTCTNAAAACTAGC GGATCCCACANGNGNTGGNTAGGATACACCα rCANGAGGCCCTNNNTGNCCCTTTNAGCA 0 CGGTCTNGGGGCCGNGGGGCATCNNGGGNACACAGACGNGGGGGACNTCTATAGCTNAC

NGCAANANTATNNTNNTAGCANAACTGTTTAGTCNCNCATGGCGNTNACTGNCNNATCAC ANTCCNATNNNNNANCTTTCTGNTCTNGNTNTTTNNGACNTATANNTTGNNCTTTCGTAAT NNTNTNNNNTNNCNNNNAGANNGANA(^ANATNNACTCNNCGCTNTCNTGACACC AGTCGATNAANGATAGNATTTTTNTNATACNTNNCGCNTNNTNNGNTCGNANACTTGNTC 5 NTNTAGAGTNTNTNCANN(^GACTTTTTOT

ANTCACNCANGNNACNCCATNANANANNGCNTCNNNTNANTTCNGANNATACATGATAN ANGTNTCAATTGNTGCTTGANTCTTCTNNATNNNANCNATCGAAGNNTTTNNACTATNNCT TTANANNNCCANNTNTNTCACTTNANTTN^ AATTNNNATCTNATTATTTNCNATATTO^ 0 GTNNNNNT I^WCAANTCNNANANTNCCTTTCNTATTNNCATANTNATGNTGNCCAATCNT

NNNACCTNAANCA(^CNCTTATTNNCNTNCNGCTATGCTNCNACNTCTANTNACTATANN ACGTATCNTNCTTTNNTCGCCNGNTAOSrCCNTATATATCTTCNTATTCTCNNCTTNCCTNAA NOSINNNTNNNATNTAGNATATCNCCTNCTGANCCTCCNANTGANTANTACCTCNACNATA NCATACTNTGNCNTNANTCTCAATTGCANNGNNTANATCCNNNCNTATGAGAACATCCNA 5 CCTNNAAAAGTNTTATANTTGNTATTGTANTGAT(^ATNTTATAANTNC JNTTTAATNTAC

TATGAT JNNTATCCNTCCGTTANGATGANCGNTTNNNTNTCNNACTGCGTATNTAGTTCCN AACTNNATNGATNACGTATNNANNTCACTNTNNTGACTGN INCNTACCT(^TNNTNCNCT NNTNTNGNANNGANATGAACNTCGCANTNTTANNTNGCNTTATCACTNTNATCTNAATGT ATNTACNACNGNGNGATGTANTAANCTATNTTATNTTTCTATNTATNNTNGATCNATGACA 0 NNTNTNGGATNCTAGOSINTNNNNTNTACCTαSINACCGCTCGTTNCTANTNN^

NGATNNCATNATTAGNACGTATNTACNTATGNTAANANCNATANGACTNTCATGATCTAT TGTATNCATlSfNNNCANACTGAATNNNANNTNTNTG 5 NANNNCGANGNNNNNANNTNNNATANATTNNANANANNANNNTNTNNNNCNANCf^^

CNTCTNTCTNTNNATATGGNATTCTTANGCANCTCNATATNGGAGNGNGGANCGAGGNAA CATCTCTNTTTGAGNCCTCNAGNGAGTNGNATTACAGTNGNNNTNCTTCTNAAAACTAGC GGATCCCACANGNGNTGGNTAGGATACACCCNCANGAGGCCCTNNNTGNCCCTTTNAGCA CGGTCTNGGGGCCGNGGGGCATCNNGGGNACACAGACGNGGGGGACNTCTATAGCTNAC NGCAANANTATNNTNNTAGCANAACTGTTTAGTCNCNCATGGCGNTNACTGNCNNATCAC

ANTCCNATNNNNNANCTTTCTGNTCTNGNTNTTTNNGAC^TATANNTTGNNCTTTCGTA^

NNTNTNNNNTNNCNNNNAGANNGANAC^ANATNNACTOSINCGCTNTCNT^

AGTCGATNAANGATAGNATTTTTNTNATAO^TNNCGCNTNNTNNGNTCGNANACTTGNTC NTNTAGAGTNTNTNCANNC^GACTTTTTNTANATANTNAATNTNNNNTAGTATNG

ANTCA<^CANGNNAO^CCATNANANANNGCNTCNNNTNANTTCNGANNATACATGATAN ANGTNTCAATTGNTGCTTGANTCTTCTNNATNNNANCNATCGAAGNNTTTNNACTATN^ TTANANNNCCANNTNTNTCACTTNANTTNNOSΠS NNATTAGNNN^ AATTNNNATCTNATTATTTNC^ATA^ GTNNNNNTNNNCAANTOSΠSRANANTNCCTTT⁽^TATTNNCATANTNAT^

NN CCTNAANCA(^CNCTTATTNN^

ACGTATCNTNCTTTNNTCGCCNCNTA(^CCNTATATATCTTCNTATTCTCNNCTTNCCTNAA NO ΠSTNTSRTNNNATNTAGNATATCNCCTNCTGANCCTCCNANTGANTANTACCTCNACNATA NCATACTNTGNO^KANTCTCAATTGCANNGNNTANATCCNNNCNTATGAGAACATCCNA CCT INAAAAGTNTTATANTTGNTATTGTANTGATCNATNTTATAANTNΣSLNTTTAATNTAC

TATGATNNNTATCCNTCCGTTANGATGANCGNTTNNNTNTCNNACTGCGTATNTAGTTCCN AACTNNATNGATNACGTATNNANNTCACTNTNNTGACTGNNNCNTACCTCNTNNTNCNCT NNTNTNGNANNGANATGAACNTCGCANTNTTANNTNGCNTTATCACTNTNATCTNAATGT ATNTACNA(^GNGNGATGTANTAANCTATNTTATNTTTCTATNTATNNTNGATCNATGACA NNTNTNGGATNCTAGT-MSTTNNLSIN^

NGATNNCATNATTAGNACGTATNTACNTATGNTAANANCNATANGACTNTCATGATCTAT TGTATNCATNNNNCANACTGAATNNNANNTNTNTG

TTNANAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGGGANNNTGNCTANCNCCCAGAANNGNCTNCANACGNGCGGNTCCGANCCNT ACACTTTGGACGGAANTGTNCCAATGANTACNTGGAACTGNTGNACCNCGNNCTGCTGNC NCTGTGGANGCNANNCNCANATTTGANGNNTCACTTNACNGGNCACTCAAAGCGTGNGG CTGGATCATTTACTGACNTCATCNNGGTTGTNNAGGCCATGAAGGNAACAGATTGGGNGN ACNCACAGGACCCCACAGTCATTGNTGAGAATGAACTCTTGGGAGCCAAGNTTGCCATTG

AGGTTGANNCCATTAAGCTGGACCACNTGATTCCTCGGACCANNCCTANGGAGGCGGNCA AGTNCTTGACTTTGANGACCATAATCCTGGAAACTTTCAATTTCCATCNAGGAAGNCACCA CCGCCTGGAGAAGGCTGCCTCATCTGNACAAAAGGACCTGGTGGNCCANGGGAAGGTGG TCNCAATTCAGCCAACTCACTTGTTGATGGAAGTGGTCCCAAGGNCCTATTTTTTTTTGCC CGGATGGTGGATTGGGGCACCATCAACCTGNGNGAGGAAAANNATTGCATTTTGGTCCAA

GGGCCCCCCCTCCCTGGAAAANGCTTNTTTTATTAAACCAAGGAAGGTTNNCGTTTTTNAA AANTNCCACNTTATTTGGAACCCTGCCANGNGCAAAGGGCCGGACCCCNGACTTTTGAAA GGCAATGGAAACCGGGTTTTAAGGGTTGGCCGGGGAANCCCCATTNAAACCNGGNCCTTT NNACCAANCCTGGGGGAANGGNGGGCCCCNAAAGGGCTGGGNNCCNTTTTTAAAAAAAC CGGGNAAACCGGAANCCCTNGGGGGGTTNAAAGAAAAAAAAAGNGTCCGGGGGGCANTT

GNCCC<^AATTTTTTTTTTGCCCCAGGANA

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGCGTAGGTTCAGNGGCGCTGAANCGGNNGCGTGGGGCTTTTAGGTTCTGTAGCTGGTCG

CAATGGCAAGCAAAGGAGGGTACATCGTGCTTGGGCTCCTGTTCCTGGCTGTCCTCTGCCA ACTCGGTCACAGCCTGCAGTGCTACAGCTGTATTAACCAAGTTAACTGCACTTCAATCGTC AATTGTTCACATAATCAAGATGCTTGTCTCTTCGTTAAGGCTGTGCCGCTAAAATTTTACC ACCAGTGTTGGAAGTACGAAGAATGCAGTTTTGAGTTCATTGCAAAAGCCTTAGGGGAGA AGGAGCTCCACTATGACTGCTGCCAGAAGAACCTGTGTAACAAAAGTGGCGGGAGGAGC

GTATCCGANAAGATACTGCTGCTGCTCACCCTGCTGCTGGAGGCAGTCTGCCACTTTTATC GCTAAATCTATGCCAGGAGGGCTTCTCCTGAATATCCTGTTCTATCTATTCCTTCCTTCGGG GGATGCTGGGTTCCAAANGCTTTTTATTTTCCAACTGGATCCTGGTTAATαSfTTTCCCTGTG GGANANACTAAAACTAAGCTTGACCACTTGAATAATAGAGGAACTCAAAAAGACTNTGA ANACCATNCTTTTGGCANAAAAAACTGGTTGAATTGAAAAAAGTTAAAAANGAACCGGG

GTNANTTGAGTGANAAGACANGGTCNTACTTTGCCCTTTGGGGGGGCAACNTTTCAAGGA CCACTTGANGGACTTGTTTTTCAATNCTTAAAACGTTTCCCTTTGGGTNCCNGGGAAGGAA ATAANGGGGAACAANCCTTTTTTNGGGGAACTTGGGGCCAGGGGGGTTCNTTTTTAAAAA ANTTTTTTTNNAA TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCTGGACTACGGAAAGCGACTGGCGGAGGCCAGCAATT AGAAACTCTGGGTTCTGGGTGCAAAAACCGAGTTAGGAGGCTCAGGCATGCTGCGTCCCA

AGGCTTTGACCCAGGTGCTAAGCCAGGCCAACACTGGAGGTGTTCAGAGCACCCTGCTGC TGAATAACGAAGGATCTCTGTTGGCCTACTCCGGCTATGGGGATACAGACGCCCGGGTCA CCGCGGCCATCGCCAGTAACATCTGGGCGGCCTACGACCGGAACGGAAACCAAGCGTTTA ATGAAGACAATCTCAAATTCATCCTCATGGACTGCATGGAGGGCCGTGTANCCATCACGA GAGTGGCCAACCTGCTACTGTGCATGTATGCCAAGGAGACCGTTGGNTTCGGAATGCTCA

AGGCCAAGGCCCAGGCCTTGGTGCAGTATTTTGGAGGAGCCTCTCACCCAAGTAGCAGCA TCATAATGGGCGTTGGTGGAAACCTGGGATTCANAAGAATGAGATGACCATGTGGTNAGG GCACGGCTTCCCCGGGGAAAACCTTCCTGGACTTGTTGCAAGAAAATTGGAGTGGGGGGG ACTTTGTTCTTNCCAANAATAAACTTCAACTGCTC^ NNNNNNNTWNr^NNNNNNNNN^

CTTTTNNTNNGGGGGGNNNNNNNNNTTNANNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNr>πsINNNNNNNNNNNN^ NNNNNNISINNNNNTSINNN

TTNANNCTATCTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGANTTGCTGANGNNNACATTGAGCTNGCNAGCGACTTCAGGGGCATCTTTAGG AGTCAGNACTATGGCAGAAGACATCCAGGCCAAAATCAAGAACTACCAGACTGCTCCTTT TGACAGCCGCTTCCCCAACCAGAACCAGACCAGGAACTGCTGGCAGAACTACCTGGACTT

CCACCGCTGTGAGAAGGCAATGACCGCTAAAGGAGGTGATGTCTCCGTGTGTGAATGGTA CCGGCGTGTGTACAAGTCCCTCTGCCCCATATCCTGGGTGTCAACTTGGGACGATCGCCGG GCAGAAGGCACGTTTCCTGGGAAGATCTGAACTGGCTCCATCCCACCTCCTCCTGTCCTCC GTCCTTCTCCCCAGGGTGGTGAAGGGGGACCGGGGTACATGGTGATCCCCACCCTGGGAT CCTGACTCATGGTATAACTAATAATAAATGCTCGTTGGAAACGTGAAAAAAAAAAAAAAA

AAAATTTNGGGGGGGGCCCGGGACCCAAATTCCCCNTTATNGNGNNNCTTTNTTAAANNN NNNCCCNGATGGGNGGNATGNNNNNCANCAACTANCTNTGTNAAGGNNTNTCCNNTTGC NNNCTTTTNNCANGGNNT ΠSINNCC^TTNCCATNNANAAACCTT^ NNNO^NNNNNNTTNNNNTTNNAAANNNNCNNNNTTCTT^ NNGNNCNNANCNNNNNΠSINTTTTNANNNNNNNNNAN^

NNNCCNNNN1SΠSIAANNNNNN(^TNTNANAACCNNGNNNNAANGNCN^

TTTNAANCTTTTTNAANNAANNNNGNNN^

NAANAAANNTNNNNGG

GCCNATNTGGAGCTNCATCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAGCTGAGAGTTCGAGAGCTACGGGACCCCAAAGACAGGGCT GGGCCCTGGCACCCTGCGCGCCCCGACCCAACACTTAGGCCAGACCATGGGAACCCAAAA GCCTCGGATACTGCCCTGGCTGATATCTCAGCTGGACCGAGGGGAGTTGGAGGGCGTGGC CTGGCTGGGCGAGAGCCGCACGCGTTTCCGCATCCCTTGGAAGCACGGCTTGCGGCAGGA

TGCCCAGCAGGAGGATTTCGGCATCTTCCAGGCCTGGGCTGTAGCCAGTGGTGCCTATACT CCTGGGAAGGATAAGCCCGACCTGCCGACCTGGAAGAGGAATTTCCGGTCTGCCCTGAAC CGGAAGGAAGTGTTGCGTTTAGCGGAGGACCACAGCAAGGACTCCCAAGACCCACACAA AATCTATGAGTTTGTGAACTCAGGAGTCAGGGACATCCCTGAGCCAGATACCTCTCAAGA CAATGGCAGACACAATACCTCTGATACCCAGGAAGACACTCTGGAGAAGTTACTGAGTGA

CATGGACTTGAGCCCAGGAGGGCCCTCGAATCTGACTATGGCCTCTGAGAAGCCCCCTCA ATTCTTTGCAGAGTCCCGACTCAAGACATCCCTTGCTCTTTGCCCAAACTCGGGACTCTTCT GAAAACCCCCTTGAACAGCTGTTGGCAAACGANGAAGATTGGGAGTTCGAGGGGACTGCT TTTTACCGGGGCTTGNCAAATCTTTCCANCAANACTGTTTTCTGCCCTGGGGGCCTGNNGN TTGGGNGGGATNANAAGCAGGGGACAGGATCTTGCCTGGGCAANCTTATACNAATTGCCG

GACCCTTGGANGTNCCTTGACAGAAAAANAACGNGANAANAATACNTGNCAACGTGGTG CTTAACTGCTNGGGCCGGGGGGCTTGGCCTTGTGGCNG NNCAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTTANGTTNGAGTCTGTATTGGACAAATAAGCACTATGCTTTTCAAATGATTGGA AAATCATTTTTATTTGCCTCCTTTTTTTGACAGTGGTTTGACTT^ ATCACTAAACTTGTGCAATGGTAGCATGGAAATTATCTGAGGTGTCTTGTATGATNGTGCT

TTGGCCAGGGTGGACATAGTTCAAATTGTAANAGCTGAAGATAAAAGAGGAAGAAGGTA TAGGTTCATGCTGCCTATTTANAAGAGAACTTTCATTCTTCAGAGCTACATAACATGATAA TGCCACTGATTCATAAGGGGTTTAAATTAATTCTATGGGGTAGGACACCAGAATCATTAGT GTTCATTNTCATCTANGGTTTTTATCTCTCTAACGTTCTTGGCCTATTGAAACATTTCAGTA TACAAAAATACTGCGATGTTAATACCCAAGANAAAAGCCATCATANTGTGTATGCTGGTC

ATTTTGATCAGTGTGGCACAATTTTTTAAAAATAAACTATCANGCCCTTCAAAAAAAAAA AAAAAAAAACCNGGGGGGGGGGCCCGCCCCCCANTTNCNNNTTAANGGGGGNNNNNAAA NNNNNNTSINfNNNNNNNNNNNNNNNN^ NNNNINNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNISIT^NNNNNN^

N]NπSfNNNr>INN[NNl^

NNNNNNNNNNNNNNNNNTSINNNNNNNN^ NNNNNNNNNNNNNNNNNNNNC

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGCTTCGCTGGGGTCTGAGCCGAGCCGAGGCCTGGCTGCTCCCGC CGCCCACAAGCTGCTGTCACCGGGCTCTGCACAGACAGGTAGAGGGCACCGAATTCCGGA GCGCCTACAGCCTGGACAAGCTGTACCCGGAATCGCGGGGCGCGGACACCGCCTGGAGG GTCCCGGGCGACGCAAAGCAAGGCAACGATGACATTCCTGTAGATCGCTTGACGATATCT

TACTGTCGGAGCAGTGGTCCTGGGGGCCAGAACGTTAACAAAGTGAACTCCAAGGCTGAA GTCAGGTTCCACCTGGCAAGCGCCGACTGGATCGCAGAGCCCGTGCGGCAGAAGATGGCT CTCACGCACAAAAATAAGATCAACAGGGCGGGAGAGCTGATCCTCACGTCTGAATACAGC CGCTATCAGTTCCGAAACCTGGCAGATTGCCTCCAGAAAATTCGAGACATGATTGCCGAG GCCAGCCAGCCAGCCACAGAGCCATNCAAAGAAGATGCTGCACTTCAGAAACTCAGGAT

AGAAAACATGAATCGCGAAAGGCTCCGAAAAAAGAGAATAAACTCTGGCATCAANAACN AGCAGGAGGGTCGGTACCGGACTTGAAAAGCACCCCCCTTCGAGCCAAGCAAAAANCCCT TNCANGGGCACCCCANGTGGGTCCGGACACCAAGGANAACGGGTGTCTNGTTCGTGTCAA CTGGTCGNCTTTTACNNNGGGAAACCGTCGCNAAGAAAGGGCCCTTCNGGAAACCCAAAN GTTGTTAAGCCCCTTGTNCCCCCAGGNNNTTTTTAAAGGGGAATAACGTGGTTTTTAANAC

CCTTCGNTNATNCATNGGCCCTGGTTTTANTGGCAATAAAAATTCTTAAN

GCCTATANNGAGTTGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG NAGGAAATTCGGCACGAGGCCCTGGTGCCCCTTTAGCACGGGCTTGGGGCCGTGTCGCAA

CAGGGGCACACAGTGTGGGGGACATCAAAGCGCCGNAAACCATGGCCTTGCAAACCGTTC CGCCCCGCNTGGGGTCCTGGGGNACCCCCGCΑWTGGNAG(^TCNTGNTCNTGNTTTTTTG CNTNGGTNGGGTTNNACNTTCNAGGNCCNAGGNTGNAAACNNGGAANNGGTTTTTTTNAC NTAAANNGNNCANNNNANNTNGNGGAACNTGTCTTGGNANAAGCNTNACNTNACNGTCT TCTTCCCAAGGGCCNGGGGGGNACNAAAAAAAAAGGCNTGCCCCCNGGGGNGGAAGGCC

AAATTGGNGAATAAAAACTTTTTTTTTATATAAGNATGTGGAACNTGAAGGCTTGTGTGA ACGGGNCCTGTTGNGI^CACCCAAATAAAAAANTGNANAACTGANATTCTTTTCATATAN CAAGANGTGCATNTTTTAAAGCGNAAANTGTANAANTTATACCCNNAGGGNNNACCCAC NNCTTTTATAGAGOSTNGAGANNTTTTTTTTTTTNTACGNCC GGAAATGACNNTTCTGTGCACACCGAAAAAATTTTTTANAAAAAANCNCCAAAGGNGCG

GNGGTGGAANANTCCNCAGGGGTGTTCCTCTNATNNCC(^TNTTTTGNNGGGGAGGAAAG GACC(^TTΓTNTANANAGGGCCCTTGTTANACCCTTGTGGATNNTTTTGCCCTGCNTTAAC NNGNGGGTTNTTTTCCGCCCQWATGAACNTGGGTANTACTTTNNNAAAATTAAANANNG NANAAAANATTTGTN

GCCTATANNGAGTTGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG NAGGAAATTCGGCACGAGGCCCTGGTGCCCCTTTAGCACGGGCTTGGGGCCGTGTCGCAA CAGGGGCACACAGTGTGGGGGACATCAAAGCGCCGNAAACCATGGCCTTGCAAACCGTTC CGCCCCG(^TGGGGTCCTGGGGNACCCCCGCCNNTGGNAG(^TCNTGNTC^TGNTTTTTTG (^TNGGTNGGGTTNNA<^TTCNAGGNCC GGNTC

NTAAANNGNNCANNNNANNTNGNGGAACNTGTCTTGGNANAAGCNTNACNTNACNGTCT TCTTCCCAAGGGCCNGGGGGGNACNAAAAAAAAAGGCNTGCCCCCNGGGGNGGAAGGCC

AAATTGGNGAATAAAAACTTTTTTTTTATATAAGNATGTGGAA(^TGAAGGCTTGTGTGA ACGGGNCCTGTTGNGCNCACCCAAATAAAAAANTGNANAACTGANATTCTTTTCATATAN CAAGANGTGCATNTTTTAAAGCGNAAANTGTANAANTTATACCCNNAGGGNNNACCCAC NNCTTTTATAGAGCNNGAGANNTTTTTTTTTTTNTACGNCCCCTGTGGANATAT^ GGAAATGACNNTTCTGTGCACACCGAAAAAATTTTTTANAAAAAANCNCCAAAGGNGCG

GNGGTGGAANANTC(^CAGGGGTGTTCCTCTNATNNCCCNTNTTTTGNNGGGGAGGAAAG GACCCNTTTTNTANANAGGGCCCTTGTTANACCCTTGTGGATNNTTTTGCCCTGCNTTAAC NNGNGGGTTNTTTTCCGCCCCNNATGAACNrGGGTAN^ GNTTTTTTTTNAANNAACCCCCCCCCNGNAANNTGNTNGGNNNGGNNTGGCCCNNCC^^ NANAAAANATTTGTN

GCCTATANNGAGTTGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG NAGGAAATTCGGCACGAGGCCCTGGTGCCCCTTTAGCACGGGCTTGGGGCCGTGTCGCAA CAGGGGCACACAGTGTGGGGGACATCAAAGCGCCGNAAACCATGGCCTTGCAAACCGTTC

CGCCCCGCNTGGGGTCCTGGGGNACCCCCGCCNNTGGNAGCNTCNTGNTCNTGNTTTTTTG

NTAAANNGNNCANNNNANNTNGNGGAACNTGTCTTGGNANAAGCNTNACNTNACNGTCT TCTTCCCAAGGGCCNGGGGGGNACNAAAAAAAAAGGCNTGCCCCCNGGGGNGGAAGGCC AAATTGGNGAATAAAAACTTTTTTTTTATATAAGNATGTGGAACNTGAAGGCTTGTGTGA

ACGGGNCCTGTTGNGαSfCACCCAAATAAAAAANTGNANAACTGANATTCTTTTCATATAN CAAGANGTGCATNTTTTAAAGCGNAAANTGTANAANTTATACCCNNAGGGNNNACCCAC NNCTTTTATAGAGCNNGAGANNTTTTTTTTTTT^ GGAAATGACNNTTCTGTGCACACCGAAAAAATTTTTTANAAAAAANCNCCAAAGGNGCG GNGGTGGAANANTCCNCAGGGGTGTTCCTCTNATNNCCCNTNTTTTGNNGGGGAGGAAAG

GACC(^TTTTNTANANAGGGCCCTTGTTANACCCTTGTGGATNNTTTTGCCCTGCNTTAAC NNGNGGGTTNTTTTCCGCCCCNNATGAA(^TGGGTANTACTTTNNNAAAATTAAANANNG

NANAAAANATTTGTN

TTNANCNCNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCAACGAGCAGGCCATCATCGACGTGCTCACGAAGAG AAGCAACGCACAGCGGCAGCAGATCGCCAAGTCCTTCAAGGCTCAGTTTGGCAAGGATCT CATCGAGACCTTGAAGTCGGAGCTGAGTGGCAAGTTTGAGAGGCTCATCATAGCCCTCAT

GTACCCTCCATACAGATACGAAGCCAAGGAGCTATATGATGCCATGAAGGGCATAGGAAC CAAAGAGGGTGTCATCATCGAAATTCTGGCTTCTCGGACCAAGAACCAGCTGCAGGAGAT AATGAAGGCATACGAGGAAGACTATGGGTCCAACCTGGAAGAAGACATCAAAGCAGACA CCAGCGGCTACCTGGAGAGGATTCTGGTGTGCCTTCTGCAGGGCAACAGANATGACTTGA GTGGGTATGTGGACCCANGATTGGNCCTGCAAGANGCACANGATCTGGACCCAGCGGGTG

AAAAAAATCTGNGGGACCGATGAAATGAAAGTTCATTACTNTTCTGGGGACNCCNCANCG CCCCCCACCTTGATGANAAGTGTTTGANGGAATATTGANAAAANTGNCCACCCAGAACNN TTGNGGGCCCG(^TCAANAGGNGANAACCCNTGGGTTCCCTTGGAGGAGGNCNTTCTTTA CAGGAATGGAAGGGCNCCCGGGAACCTTCCCCGGNTNCNTTTGNGGGGCGCCCNTTTCNT TTGCCATGAAAGGGAACCAGGGACTTTTGGTTGGGGACCCCTGANAAAAAAAAATTCGTT

TTCCCGGGGGNGGGNATTGGCCTTTAAATNTTTTTCAANNAAATCANTTCNANNAAAAAT TTTCCGGGGAAAAACCCTTTNNOSINNNTTTGTTTTTTGGGA^ ATACAAAAAANAGNCCCTTTTTTNAAC

NAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCTCTGTTCCTAATGTGCATGGGGCTTTGGCCCCTCTGGCTATTCCGTCGGCAGCGGCA GCAGCAGCGGCAGCGGGCCGGATCGCCATCCCAGGCCTGGCGGGGGCAGGCAACTCTGTC CTGCTGGTCAGCAATCTCAACCCTGAGAGAGTCACACCCCAAAGCCTCTTTATTCTTTTCG GCGTGTATGGAGATGTGCAGCGTGTGAAGGTCCTGTTCAACAAGAAGGAGAACGCCCTGG TGCAGATGGCCGATGGGAGCCAGGCACAGCTGGCCATGAGTCACCTCAATGGGCACAAGC TGCACGGAAAGCCAGTGCGCATACACTTNTCTAAGCACCAGAGCGTGCAGCTGCCCCGCG AGGGCCAAGGAGGACCAGGNCTGACCAAGGACTATGGAACTCGCCCTTG^CCGTTTNAA AAANCTGGCTTCCAAAAACTTCCAGAACATCTTCCACCCTNGGCCANTNTGACTTTTCAAC

ATCCCGCCCTCCTTNTTTTGAGGATAACCTCAAAATTNTTTTTTCCATAACCGGGGGGAAT CGTCAAANGGGTTCAAGGTTNTTTGAAAAAGGANCCGNAAAATGGCGCTTGATNCCAAAT GGGCTTAAGNGGAAGAAGGGCATTCCAGGGACTTTTTTGAACCTGGGCCAAACATTGAAC TTGGGGGGANAAACCI^CCCNCTTGGGGGGNGGTCCTTTTTCCAAATTCCCCCATTTTAAG GGCCGNCCANCCCAGGAAACAAACCTTGGCNGGGGANNCCCGGGGAANNAAATTTTCAT

TTNNTTTTCNNAANAAAAAAANCCCCTTTT^ NAAANAAACCCAANAAATTTTNNTTTTTTTTTAAAAAAAAA^ TNTTTTNAAAAAAAAAAATTAAAAT

NAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCTCTGTTCCTAATGTGCATGGGGCTTTGGCCCCTCTGGCTATTCCGTCGGCAGCGGCA GCAGCAGCGGCAGCGGGCCGGATCGCCATCCCAGGCCTGGCGGGGGCAGGCAACTCTGTC CTGCTGGTCAGCAATCTCAACCCTGAGAGAGTCACACCCCAAAGCCTCTTTATTCTTTTCG GCGTGTATGGAGATGTGCAGCGTGTGAAGGTCCTGTTCAACAAGAAGGAGAACGCCCTGG

TGCAGATGGCCGATGGGAGCCAGGCACAGCTGGCCATGAGTCACCTCAATGGGCACAAGC TGCACGGAAAGCCAGTGCGCATACACTTNTCTAAGCACCAGAGCGTGCAGCTGCCCCGCG AGGGCCAAGGAGGACCAGGNCTGACCAAGGACTATGGAACTCGCCCTTGO^CCGTTTNAA AAANCTGGCTTCCAAAAACTTCCAGAACATCTTCCACCCTNGGCCANTNTGACTTTTCAAC ATCCCGCCCTCCTTNTTTTGAGGATAACCTCAAAATTNTTTTTTCCATAACCGGGGGGAAT

CGTCAAANGGGTTCAAGGTTNTTTCAAAAAGGANCCGNAAAATGGCGCTTGATNCCAAAT GGGCTTAAGNGGAAGAAGGGCATTCCAGGGACTTTTTTGAACCTGGGCCAAACATTGAAC TTGGGGGGANAAACCCNCCCNCTTGGGGGGNGGTCCTTTTTCCAAATTCCCCCATTTTAAG GGCCGNCCANCCCAGGAAACAAACCTTGGCNGGGGANNCCCGGGGAANNAAATTTTCAT TTNNTTTTOSINAANAAAAAAANCCCCTTTITNAAAAAGCNCGGT^

NAAANAAACCCAANAAATTTTNNTTTTTTTTTAAAAAAAAA^ TNTTTTNAAAAAAAAAAATTAAAAT

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGATTCGGCACGAGGCCAGTTTCCAGTTGTGTACCAAGGATGATTGCTTCAGTGTTAATA TTCAGCCTCCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAA GGAGCAAGGCATGCTCTCTGGAATGAATGAAACTTCCACCACGATTATTGCTGCCCCACA GAATTTTGCTTCCTCTGTGATCCTTCAGAAGATAGTAAATGTAGCCAATGTGGGTGTAGTC CCTTCTGGACAAGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTG

ATGCTAGTCACAGTGGAACTGAAGGAAGGCTCTACAGCGCAGCTTATCATAAACACTGAG AAGACTGTGATTGGTTCTGTTCTGCTGCGAGAGCTGAAGCCTGTCCTGTCCCAGGGGTAAC CTGCTTACATCTGGACTTCAGAATCTGGCACACAACACAAGTCCCTGGCATCCACTGCTGC TGCCTTTCATTTATAATAATAGCCCTTCCATCTGGCAGTGGGGGAAGAAGACACTCTTGAC ATTCTTGGCTCCTGCTTTAAAAANGCTGGGGGTATTCTATCGNGAATGCAATACTTTTCCC

CCTTTTCACTTTGCTAACCAAAGAACATACATTTTGCTGNCAGGTATCTCAACTTCCTAAA ATCCATTTGGCATTTTCTTNTGGCCTGNTA(^TTNTTTTNGGCCCTTCGNGGGTT^ CTTGGTNTNAANC(^ATGGANNGGACCAGGAAACCGGGAANCCC1TGGGNTTTTTTGGGA NAAAANTTTTTCNTTTTCCGCAGTAANGCCAAAAANTTANCCCTAAAAAATANNNGACCC TGGAACTNTTTα NNTTGGNNTTTAAAAAAAAANGGGGGGNGTGGTTNT

AAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGCAAAATGGTTGCCGGGTTATGTTAATTGGGAAGAAGAACAGTCC GGAGGAAGAAGCTGAACTAANNAAGCTGAANGATTTGGAGAAATCTGTGGAGAAGATAG

CTGACCAGCTGGAAGAACTGAATAAAGACCTTGCTGGAATCCAGCAGGGTTTTCTGGCCA AGGATTTGCAAGCTGAAGCTCTCTGCAAACTCGATAGGAGAGTAAAAGCTACAATTGAGC AGTTTATGAAGATCTTGGAGGAGATTGACACACTAATTCTGCCAGAAAATTTCAAAGACA GTAGAATGAAAAGGAAGGGTTTGGTGAAAAGGATTCAGGCCTTCCTAGCCGAGTGTGACA CAGTGGAACAGAACATCTGCCAGGAGACAGAGCGACTGCAGTCCACAAACTTGGCCCTTG CTGACTGAGGTGAGGCGGAGAAGGCCCGTGCTGCACTGAAGAACAGCCCCACCAGCCCTG CCATCTCTGGAACAGAAGTTACCTGCCTTCCCCAGCGCTTGCTGGGAGCAATTGGCCCGTT GCCTTTTCCTTCTCTTACAACCCACTCTCAATGAACAAGTGTCATTCCTTCCAATCTTTAAC CTTCTATCAGCTTCTCGTTCTGGCTCTGGGGGATCTGNGCTTGTCCANCANCCCCNCNTTGT

TTGGGANAGGGCCCCATGACCAAGTCTTTCCAACTGGNTTGGANCCTTTGGGGGCTTTTNT TTNGGCCTGGGGAAAACTTNTTATGTATCCCGGNGGAAGTTCTGAANTTTATTGGNCCNTT TTGGGCCTTCAAAAACCAAAAAGGNCCTTTTTGGTTTTTATGAAACCCCTTAAANCCTGGN TTGGGT

GNAGNGOSINNNCTTNTCTTTNNANTTNNNNCTTNN^

NNCCTCACCTCNCTCCACCCGNCCNANGGNNNGNNCTATNTTNTNTNNCTCTTTANAGCCC

NNTANGAGTCGCATACANGGNNTSINCCNTαsrCATCTTTTCCTCCTCTTTTCGCACNCNACCT TCTCNNCNTTTCTTNTNTAAN^

NNGNNGNNGTTTCNATGTTNCAATTNNNNTTAGTNNCCANANNNTCNTATCCANCANTCN NTCCATTNTTNAANACGNTNTCCCCTTNTTN^

ACAGTGNANNNCNCTNANTTTTNNNNTANTCTTCANATGTNTTAGNTCNNNNNNNTπ CNTCTANNNTANNATANNANTNACANNTATGNNTNNTNTTNTNTCNGNTTAANGGNCANN NTACCTTATNNTNTCTANNNNTCATNNAGTATTTTTTTCNTTTTN

TATTTNNAGGTNNNCANTTCTCNCTCACNGNGTCATNTTTNTTNTTTNCGTT^ CNAATTTNNNNTCNAGT WANTNTTATTNNTNTNNTNNG^ TNNGNT(^TTGCTCTTCNNNCNTNNAGCNTNCTCTNATCCCTNT(^TNTTTπ TNCCNCCTCCTCCTNCCNCNNTTCTCNTNNTTCGNNCCTNTANCCCGCAGTNCCTCNCTNC NTATTTCAGCCAATNCTCNCNCCGTANNCCTTCGTTCTNTCCTTTGNCTTCNTNACCNCNN

NNTGTTTTTTTNNNATTNTCNNCTCTTANNNN^

NNCTNNTNTACTNCCATCANTSπslNCCGTCCNTACTTGNACGTCNATNTSfANGTGANATTTN^ NTNTNGNNNGGTCNCCTNTTTTNCGATATNNNNACATTCCCNTTNTNT^ TTATTGNNCTGNNNNTNNACTNC.^ NCGCTTCGGNTNTCCTGTATNTTNCNTCTGNTNNTGCTNTNTATNATNCTCTNGANCTCTA

TATGCGTTTATCANTATATNTNCNTNATCGNCGTCTTATCNACNTTNGNTCNNTAACACCG TTNNTCATCNCNNTSINNTTTCTCTCTTTACNCNCACATTGTTNAACTNGCNGCNC ATTCTNCTGNTATNTGNGNGTTATNTNGACCTTCTCNTNATNATATCTTANATATGTCTNG ATNTGCTNGACNTNCGCANNTGTISINTCCT^ TGNTCNANANTNTNATCATGTTGTTNNGNCC

NNCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTNGGATCCCCCGGGC TGNAGGANTTCGGCNCGAGGCTCATGCTTATCATATAGTAAACCCAAGCCCTTGACCTCTT ACAGGAGCTTTGTCTGCCCTCTTAATAACATCCGGCCTAACCATGTGGATTTCACTTTANC

TCAATGACCCTGNTAATAATNGGCCTACCACCAAATATACTANCANTATACCAANGATGA CGAGATGTTATCCGAGAAAGCACCTTCCAAGGGCACCATACCCCAGCTGTCCAAAAAGGC CTCCGTTATGGAATAATTCTTTTTATTATCTCCGAAGTACTATTCTTTACCGGATTTTTCTG AGCTTTATACCACTCAAGCCTCGCCCCCACCCCTGAACTAGGCGGGTGNTGACCCCCAAC , AGGCATTCACCCACTAAACCCCCTANAAGTCCCACTGCTCAACACCTNTGTCCTATTGGCT

TCCGGAGTTTCTATTACCTGANCCCATCATAGTTTAATAAGAAGGGGACCGAAAGCATAT ATTACAAGCCCTATTTATCACCATCACATTAGGAGTCTACTTCACACTACTACAAGCCTNA

CACANGCTTNCACGGGCCTCACGTATNATTGGGCCCCCTTTTTAATGGCTGGTTCTTCCGC CAAATAAAATTTATTTTATTTTAACCNCCCCTTNNGTTTTGAAACCGNTGC

ACTTTTNGNAAACGAAGNCGGACTTTTCCCTTTAGGGNNCTATCNAAGGGNGGGGGCTCC

CAAAAAAAAAANNNNNNNNNNNNNNNNNNNNNNNN^ NNNMSπStt^NNNNNNNGGGGGGGGGGGGGGGCCCCCC^ NNTsπsπSlNNNNNNNNNNAAAANC

NNCCCATAGAGAGGANNGGNGNGNCANANNANCGTCGACTGAGCCCNATNGGGAGNCGC ANNACAGGTGGCGGCCGCTATAGAACTAGNGGATCCCCCGGNCTGTANGAATCTCTGGCA CGAGGCGANNTTTTTTTTTCTTTNTTAN^ ANGGGGN<^CCCCNT<^CTTTCGNATNGNNTNN^ TTTTGNTTAATGNGNCCTGGAGNCNTGCGNNNGGGNAANATTATNNNNTTACTATTCANN

NNNCCGt^TANAACTTTTTTNt^TTATANCGNNGNCGTGTCCATCANGGNNTTANNTAN^ NNATTANAGGGCNCCCCATNCTNGGTGNATOSlNTGGGNNGTA(^AAATTTNTCTACNCNN

NTTAACNA(^ANNNGGGANGNTNNGGAGGGNATNANTNANTCCCNTTTACNAAATAGNC NTNTNTTCTTTTTGTNNNACNTGNTNTTTTTCNNGNGNNAGCTNT^ TNCTGANNTTTNTAAANATGTNNNNTNGNGGGGGGGCTCCTNTANNCNNTCTTNNGANAN NAGNNNCTTTNOSfTTTNTCNNCNNTNGGGGGNTGNANATTTTNTAAGNNCCGT^ NCCNNNNTTC πTCCCCCNCTNNTGNGTAATO

TNAGAAANNGTGGNNNNTNTNNANNCNGNAAOWGATGNNTTNTTCCNANNT^ NCNANTGTNCTCTAATTTNNATCTTTTTNTGACCTANTTCNTCTCCCTTGNAATACAANTCT NNNNNNNTCTTTGACNOSfGTTTCACGNNCGNNAANTATANATANANNCNCTTCATNTT^ CTTTTTCTTANTNCCCANTAAAANTNTGTN^ NAANGGAGAGGGGTCGCTTNTCT(^TNTT>m^^

N(^ATTTNTNTNGTNTNTAGTTGCACNNAGANANTNNTTAACTTNANNNNGCCCNCGNGT

NATATAAANATNNAGNANGTT(^TσsrCTNTTTCACNANACCTTAGTTTAC(^CTNCNTCNN

TTNTAAANANATACGTCGCTNCNGNNNGNTNNCCNCGCNACATNNGCTCTCTCCG

TGGAGGCCNCATAGGGGAGTCGTCATTACAGGGGGGNGGNCNCTCNAGNAACGAGTGGG GATNTCNCTAGNGGTTGGATGCATNCTCCCGATCTTTNGNGTTTTTNNNTATNCTANGNTC CANNAGAANNCTTNCNAGNCGGGGGAATTTATATACTAGTAGTTTNACANNTACGNCCAC NCNCTCGTCAGACTCGNNTTCNCGCTGTNCNNTANTTNTCNNANNCTCNACANGANANTN GNNCNGTNGTTGTGCCNNTAGATTNNTATCTNTAGAGNGNNGACNTGATGNCATGAGAGN

CGGCTAGAAGTNAGCGAGGNGCGANANGTTNCANTTTANGCNNNCACGATGNACNANTN ANCNAGANCNCGNAGANGANGCGNANNNGAAGTNGANNCGACTTCNGAGTTNGNAGGG GNNGNNNNNGATGNTNCNGNNNCTATGNTCCTCGTGGGNCNCGNGAGNGNATCGTGNTN NGNNTATGNNTNGNGANTCNCGAACGTNAGANNATNANNANCANGTGNNTAGACGGGTC AGAGNNCNNAGATGATAANTNANGNNTCCGGANNNANTNCGGATATNANNNATANNTNA

TNTNNTTNTGAANACTATATCTGNNCCNTGCTCGNNANNCNNTGTNCGNNNCGATCANGT TGNGAGACCNTNTANNGCTGTATTGGGNTTNTNNTNNNGAGNNCNTNNNNCCCTAGGGGA AGNNTAGGNATNTATCNNGAGNNNNNANAANTCNNNNGNTGNNTNACAATNTNACNTNA GANNTANNNNTNANNCCACGATNNCNGTCGAGNNTNCNNGNNNTGTATCNAGN(_MSfNNN

GNGGNNNTCTCTCATNTATNNGTT^

ATANCTCTNNCTNGTTACCNCGCATNANNNGCGNTCTATTTGGATCTCGANGAGNTCGNA TAGTACNTNNCACGTNCCCANGCNTNTGNANGGNNNNNNGCNATNNTCGGNATNANNCN GAACTNTNNTATCNATNANACTGTNGAGAGAGCATAGNNNGNTNCATGNTNTCTGNANA ANTTNCTTNNCTGANTNNGANCGTACNTANNNGNGNGTAGTTANNNACNATGNANCNTA

NTANNNNTTTATANCGTGAAAGATGTNGNACGNAGTNGGAANATNAGAGTANTANCTCG NNNGNTGGGTGANTTACNNTNGGATNCNTGNANGGCGANANNATGNCGNNCGTATGNNN NTGTATTATCGNTCGTNNATGGGATATCGNNACGCNCGGTANTACGTTNNTATAGTACNC TNTTCNNNGAGNNNCTTNCGTCNNGGNGCAGACGNAANTGANGAGGNANCCG

TGGAGGCCNCATAGGGGAGTCGTCATTACAGGGGGGNGGNCNCTCNAGNAACGAGTGGG GATNTOSICTAGNGGTTGGATGCATNCTCCCGATCTTTNGNGTTTTTNNNTATNCTANGNTC CANNAGAANNCTTNOSfAGNCGGGGGAATTTATATACTAGTAGTlTNACANNTACGNCCAC NCNCTCGTCAGACTCGNNTTCNCGCTGTN(-M^TANTTNTCNNANNCTCNACANGANANTN

GNNCNGTNGTTGTGCOWTAGATTNNTATCTNTAGAGNGNNGACNTGATGNCATGAGAGN CGGCTAGAAGTNAGCGAGGNGCGANANGTTNCANTTTANGCNNNCACGATGNACNANTN A^CNAGANCNCGNAGANGANGCGNANNNGAAGTNGANNCGACTTCNGAGTTNGNAGGG GNNGNNNNNGATGNTNCNGNNNCTATGNTCCTCGTGGGNCNCGNGAGNGNATCGTGNTN NGNNTATGNNTNGNGANTCNCGAACGTNAGANNATNANNANCANGTGNNTAGACGGGTC

AGAGNNOS1NAGATGATAANTNANGNNTCCGGANNNANTNCGGATATNANNNATANNTNA TNTNNTTNTGAANACTATATCTGNNCOSfTGCTCGNNANNOSnSlTGTNCGNNNCGATCANGT TGNGAGACαsrTNTANNGCTGTATTGGGNTTNTNN N NGAGNN(^T INNNCCCTAGGGGA AGNNTAGGNATNTATt-MSTGAGNNNNNANAANT^^ TTTTTAGNNNNNTCGCNTTGTTCGNNGOS1NNGNNNCNNG GNGGNNNTCTCTCATNTATNNGTTTTCCOT

ATANCTCTNNCTNGTTACCNCGCATNANNNGCGNTCTATTTGGATCTCGANGAGNTCGNA TAGTACNTNNCACGTNCCCANGO^TNTGNANGGNNNNNNGCNATNNTCGGNATNANNCN

GAACTNTNNTATCNATNANACTGTNGAGAGAGCATAGNNNGNTNCATGNTNTCTGNANA ANTTNCTTNNCTGANTNNGANCGTACNTANNNGNGNGTAGTTANNNACNATGNANCNTA NTANNNNTTTATANCGTGAAAGATGTNGNACGNAGTNGGAANATNAGAGTANTANCTCG NNNGNTGGGTGANTTACNNTNGGATNCNTGNANGGCGANANNATGNCGNNCGTATGNNN NTGTATTATCGNTCGTNNATGGGATATCGNNACG(^CGGTANTACGTTNNTATAGTACNC

TNTTOSINNGAGNNNCTTNCGTCNNGGNGCAGACGNAANTGANGAGGNANCCG

TNNANNANNNTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGGCANGACCACGAGGANAGAAGGCTGCACCATCTGAN

GACCCTGCANGGTGAGAGAATAGANCATTACAAGGCNNTGGAANAAGCACTNAACTCGC CGATCCTTTGTCTGGGGCCGAGATGGNAGGTGGAGCCTCAGGAAGCCTCCAGAGCTGTTC ACCAGANGGATGCTGGCGCANNAGAAAAAAGTTCCTGGCTCAGTTCACCACGCACCAGCG GACTCGCCGTGACACGCGGAAACNGAAAGGCGAGGGTCATGGACCATCTGGAAGCCCAG CTTGAGACCCANCTACAGGAAGCTGAACAGAACTNCATCTGAAATCTTGGCAGCATTGGC

CCGGGTACCTCTTGCCGAAAGCTAACTATTTTCGAGTAAACGTGGTCTCTCAGCAGAGAAC CCCCTGAGGACTAAANGGGAACNAAGCCTTCTACCCCGATGAGAGAGGGGACACTTGGG GNTCCCCAGGATGATGACCCTGCCTTGGGGGGCCCCACGTTCAGGATCGCTCAACAAAAG GCTGATGCCAGCAAGAAAGTGAAGTTGGTGATGGCTANAAATTCCATAAATATGCTTANA AANAAGAAGCCATCTGTAACTTTAAGGCTTGCTCAAGACANGNCCTTGAAGACCCGGGCN

TTNTNTTGAAGNCCA(_^TTGCCCCTTCCCCCAGGANGAATTTGCCCNCCCCAAGGGTANG GGGGGACAAATGGGGGTCNTTTCCTTTTTGCCCCCCCGGCTTTGTGCCAGGGCTTGGGAAA AATGGGTTGGCCAAAATTNCCCAACCAAAAGGNCTTTAAAAAATTANGGGNGGANCCCTT CTTGCCTTTTGAAAAATGACCAAGCTTNCCCGGGGTTNGGGAAAAACCATTNTTTTTNAAG GNTTTTTGGCNTCCCCCCCGGGTTTTTNANAAAACC

NCNACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA CCCGGGTNNAAAAANGGGGGTTTTTTTGGGNACCNCTTNGNNTTTCCAANNNN^

CCCCCCCNNNNAANCCCNTGGNNGGGGGGGGGGNGGNNNCCCCNANNCNGGNCNGGGNT NNTNAAAAGGCCNCCNNCNNAAAAAAAANCCNTTTTNGGGGTTNNNCCNGGGGGGCNAA

ANTrWTTAAANCCC TNNAAAAANTTTNGTN^

TTT WAANGGCCCCCCCCCCGGNCCNTTTNAAAANNTTNNTNNTNNTA AAANAAANCCC CNNAAANNNNGNGGGGNGGCOSTAAAANCCNTTNNNNNCCC^AAAAANNNNN^

CCCNNCCCCACTTANCCAAATTTTTTCCM πSfTTTAAGGNNAACCGGANAAAATTTGGGAA

TTTTNGNGCCCNCCGAAANTNNTTTCGGANGGGGAAGGGGGAAAAACCTTTGGGGGGNG GGGTTTTTTTTTGGGGCCCCNATTNGGGTTCAGGA

CCCTTTTTNNAGGCCCCGNACCNTTTTTAANGGGNNNGGGGCCCCAATT^ AANNANTTGNGGTNAAACCNTTTGAAACCNCAAATTTTTCCCCCTTTTGGGGAANNNCT^

TTTAAANGGGCNCCCCC TTTNCANAA^

TTTTANNGGGNTNTTTTGGGAAAAAAAAAAAAANTNTCCCATTTTNCCCAAAAGGGAAAA

AAAGNCCCCCCNGGGGGGGAATTTNNCNAAANTTTNGGGGGGGGGNGGNNAAAAAACNG

GNGTTAANGAGGGG

NAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCGGTCACCCTCGGTTCCAGGCACCGCACCGGGCTAGCGGCA ACATCGCGTCCATGGCCACCACGGCGGCTCCGTCATCTTTGGCCCTCAGGGCCTCGAGCCC GGCCGCGACCCCCAGTTCGTACGGGGTCTTCTGCAAGGGGCTTTCCCGCACCCTGCTCGCC

TTCTTCGAGCTGGCCTGGCAGCTGCGCATGAACTTCCCGTATTTCTACATCGCGGGCTCCG TCGTTCTCAACATCCGCTTGCAGGTACATTTTTAGAGCCCTGGGGATGCCGCCGGCGTTCC GGGCCTGCGTTGTGGCCGACTCCCAGGAGGCGCCGCGGCACCGTGGAGCTTGGGGCGAGC AGTCCCGCTGTCTCGCGAGAGTGCTTGGTCTCCCTCCACCGGTGCGCTCTCGCCTCTCCGN CGTCTGCTCTTCTTCCGATCCCCTGAACTGGCACCGAAAACCTCCTGAGTGTANGAAGANG AAATACGCGATTNCCGGGAACCGAGAAACTTCAGTTAAAAACCCCACTACAATATTTAAA GAAGCTGTGCATTCCTTTAAAAACGGGAACGAAACAGGATGTANTTATAACAANGGGAA AGGCTGGTCCAAAACTTTTAAGGACAAGAAATGNACAAACCTTAANGGGCCGTATTTATN NAAATAGGAAAANTTTCGGGGAANAATGAAAACTGGGATTNTTAAACCGGGGATCAGTC

CNNAANCCTGGAANAATTTTAANGGGAATTTGCCGN^ TNTTTCCCCAAACCGGAAAAACTTTTTGACGAATTO^

AAAAAAAAAAAAAAAATTTGGGGGGGGGGGGCCGGGNCCCAAATTNCCNTTTNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNA

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGATTCGGCACGAGGCCAGTTTCCAGTTGTGTACCAAGGATGATTGCTTCAGTGTTAAT ATTCAGCCTCCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGA AGGAGCAAGGCATGCTCTCTGGAATGAATGAAACTTCCACCACGATTATTGCTGCCCCAC

AGAATTTTGCTTCCTCTGTGATCCTTCAGAAGATAGTAAATGTAGCCAATGTGGGTGTAGT CCCTTCTGGACAAGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATT GATGCTAGTCACAGTGGAACTGAAGGAAGGCTCTACAGCGCAGCTTATCATAAACACTGA GAAGACTGTGATNGGTTCTGTTCTGCTGCCGAGAGCTGAAGCCTGTCCTGTCCCACGGGTA ACCTGCTTACATCTTGGACTTCAGAATCTGCACACAACACAAGTCCCTGGCATCCACTGCT

GCTGCCTTTCATTTATAATAATAAGCCCTTCCATCTGGCAGTGGGGGAAANAANACACTCT TGACATTCTTGGCTCCTGCTTTAAAAAGGCTGGGGNGNATCTTATCGGGAATGCCATACTT TTCCCCCTTTTCCNTTTGCTAACCCAAANAACATACATTTTGCTTGGCAAGTTATCTTCAAC TTNCCTAAATCCANTTTGGCANTTTTCTNTGGGCCCNGGTACNTTNTTTTNGGNCCCTTGN GGGGTTCCCTTTNCCTNGGTTNAACAATGGATGGGACTTGGAACCNGGGAAACCTTTGGG

GTTTTTTTGGGNNAAAAATTTTTTCNT^ AAATTTNNNNNACCTTGGATTCTTTTTA

GCCTATAGTGAGTCGTATTACANGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGAAAAGATCCAAATAAAGAAAAACAAGCATTTGTGAAAACA GTTAAAGATCAAGCTTCTGAAATTCAGGTGACAATGATGCTCACCGAAAGTTGTAAGCTC CGAGGTCTTCATCACAGAAATCTTCTTCCTATTACCAATGTGTGTATAGAAGAAGGAGAA AAGCCCATGGTGATATTGCCTTACATGAATTGGGGGAATCTTAAATTGTTTTTACGGCAGT GCAAATTAGTAGAGGCCAATAATCCGCAGGCAATTTCTCAACAAGACCTGGTCCACATGG

CTATTCAGATTGCCTGTGGAATGAGCTATCTGGCCAGAAGGGAAGTCATCCACAAAGACC TGGCTGCTAGGAACTGTGTCATTGATGACACACTTCAAGTTAAGATCACAGACAATGCCCT CTCTAGAGACTTGTTCCCCATGGACTATCATTGTTTGGGAGACAATGAAAACAGGCCGGTT AGGTGGATGGCTCTTGAAAGTCTGGTTAATAATGAGTTCTCCAGCGCTAGTGATGTGTGGG CCTTTGGAGTGACGCTGTGGGGAACTCATGACTCTGGGCCAGACACCCTACGTGGACATC

GACCCGTTTGAGATGGCCCGCATACCTTGAAAGATGGTTACCCGGATAGCCCCANCCAAA TCCAACTTGTCCTGGATGAACTAATTTGCCGTGATGGGCTTGTTGCTGGGCCCTTTAAAAT CCNGGAGGAAGAGNCCCAANGTTCCAGCACCTTGGTCCANGGGTCTTCCANAGTTCCCTT GCCNGNCCTTGGNGGGCCTTNTNNNTTGACTNTGNNTGGNNNAATCTTTCCNAGCGGTCC ANGAANGAATGGGGCCTTCCCGNGCCTTNTTNGGANCCAAAT( NTNGAAGNCHNNTTNGT

TTNCGCCNNNCCCACANAAANCCCNTTTTTTTTTNCCAAAAAANCTN^ G

GNCCCTANTANGTGNGGTCGGTAATTAANNNGGGGGNTTCTCATATCTNCATCNTNNGTG

GGATTCOSINNTNGGGTCTNCCANGNNATNα ^

TCGANACTATNTNTGNGAAGACGANATGNNTAGGGNCTNNATATNNTCNGANANAGTNN ANANANTGTNTNGTAGCTAGNGAACCATNGANNNGCGCNNTNNGGTNCNNGTCANTCGA GANGCACGTNGNTGATACHSINNAGAGNGNGACGNNANNNTNACNAGTCTNCATNAGCNCN AGTAGANNGACATNGNAGTGAGAGATATATNNATTACAGCGACNTCNGANNCNNGTTCN

TTAGTNGANAGANNCNGTNNGNCANGAGNGATGGANAGNGNGAGAGNGNGNCGNTGAT GTGAGNATAANNNGNNACNCCNTCGNNANCGαsrACANNNNTGNNGCNANACACANTNAN AGCGCAGNANACNAGAGNTTNCNATACNNTGNGNCTGNTGNGNGNNNGACNTGNGTCAG NANANTNNCNGATCCNGACGNNNNANNGNNTGATAACTCGTNANNNAGTNCCNAGNGCN (^TGTTNNAGTTATACOSfAGTCNAGAGGTGNTCGACANCGGNAGGTGANNCNNANNCTN CaWGAGGAGX(NACATNCTmCNam<[ m<l

NNAANTNGTA^NACGNACACISΓNGNANATATGNGNTNNNANTGNTNGTAGNGNGNCNNNAC NNOSLNTCANGNGANTLNNTGAGGΑSRANNANTATCGNNTGGACCNNNNATANNANGNTGAN CTCCNCGATTNCNTANACACCAGTAGGNACGNTNTGNNANTNGNGTNNTGAGANNNNGN

AGTNATNTNCGTGCTNNCACNATTTTCNNNCGTAGGAGNCTGNNNNTGNNNTCCGAGNTA TNCMWTTTNNNCNGNNGTAGTGTGTAGCGGATGT^ANACAGNTTCGCGCNTTCNNANNA GNNNTANNTCGNNGANTNAGGNGCTCTAGNGGNTGTCGACNNNCGAGNCCTCNCNNANN CNAAGNNTNNNTCNNCATNAO^GTTNGCGNCGTAGNNNATGATCGNGNCCTTTGATOVF^ (^AGTNNTTANGATATNTCNTNACATATCANNCGCAT(^ΣSITCGATGTNNN(^TAATTNA

TCCCCNTTNNNANGATNCGTGNTNNNNAANGTAATGCGTCGNGNNNCANNNCATNANAA TTGNTCTNTCCGNNTNNAANCATN(^NACGCTACGNCTTNTNAC3SINCNNTNTGTCTNCGA CGNNACGGNATNCTTCCTNATCTNACIWGACTT-^^

ATGTCCG

NCT(^ANAGNNNNNNGNNAGNGCGAAGGACCACTNTTNGTTNTANCCCCTTACTGANNCC

NNNTTACAGAGGNTNATCTGNNTTCTCAGTNAANCANNCANTNCTACTNNAATTNCNAAA TATNNTCCAGNACTTCTANTCATTANGCTGGGTANTNNTAAAACTTCATCTTCTGGNNTNT TTATNNAACCGNGGACAATNNTCANCNNCANCAATTCTTCTCNNANTNTNCCCNAAANTT

AN(^TNANGACNATAACANNNGNNCNATAAATNATTTNAANCNCTTTTAATNNAATNCTA CGNNCCOSπSfTCTTNAANATTTCATTATTANTNATGNCCCAT<^CAACANNTCTNT^ TATT GAGCNCNANNGGANANNCTNTTTNNCANTTNNCATAACAACCNAANTATCTTNT NANTTAAACANNCANTNACANANNNCATNNTACTTANTNTANATANATNNANCCNNACA ANNAANTNNTACTCNTT(^CTNNAANTTNNNTNANCCNTNTCNNCNATANAANNANATNA

NNTAANNNNCGCTGNGOSINNCACTNTATNTATNNATAATAAANAAACGCCTCNTNCNNG ACNNTTNANTCNATTNANANACTNTAAAATTCTAACNATCNTNANGCNNGNTTNATCCCA NTTAANTCA(^C(^CCCCANNTATAATTCN(^TTTNTNATTTGCACNGNTCNCTNAANNT^ TCCTTAAlSfNTNNACNNNIvlNATCCAAANANCATCαSfCNTATCNNCCTNTTAATNNTAANGA TTTNNNTATNCNCTTNNCGNCTGTC^^

CNCCCANNANGNATNNTNTTSfTTATNTCNTTCANNGNNCTATCAATCNTNAANNNAGTATA ATTANTNTNTNACNNCTNCCNNACATGCCNCNTANTAANCNANTNTNACCATCCATCTCC CCATNTGNNATTCTTCAAGCTNCCNANNNNGCCTCNANNANTCTANNNNCGANCNATAGC NCCNTCGCTNTACNNTCCNCTTATCANTGCCTCNTACTNANNNGCCCTNNCNNNTNNGNT AANATNTCNGNCACTNCTNANAACNNNTCNTAACANGAGATCTCAANNATCAANCNNAT

GNATGCAGNTCNTTANTCTGNTNGANACNCTNANANCNTCACCGATTATNNCGGNNTNTC NATCANTATATNAGCCAGANTNCACNCANNAACNCNNATANCGTTAANATAGCATNTCAC TNNNATGAC TATCTCTTAGTNANNNTGACTC^ NNTNTCTNCNNNATNCGGACTCGATNNACTNANACTCNNNNNCTCACGTNNACAATNNAG CCG

TGAGGCCNNNTAGTGNNGTCGTATTACNGGGGCGGCCGCTNTATAACTAGTGGATCCCCC GGGCTGCAGGAAATAACTCTGAGNGGTTTGCCCTTAACTTCTNCAATGNATGANAGTGAA AAATNTAGTTGCTTAGCCGCTCANNCGTGNTACAACTCTTCGGNGACACCATGANCTATA

NCCCAACAGGCTCCTCCGTCCATGGGACTGAANAATCCTGNAGTTTANACCATGAAGAGG CACTNNGGGACAAGCTNNGTATCTNTGGNCTGATNAAANGACCATGCGNAAGTGACTNTG GAACTGGNTCNGNCCAATNGCTTCCTGATGCTTGCCANNNTCCNNCCTNNCTNGNTTGGA TANTCTCNGNTGAGGAATCANCCCAGTNTTGCNCTCCTTGGGCTTGNTACTNGCACNATGA GANATNAGACCCTANATTGGNTTGACCNNAGATCCGTNNGNAACACANNTNGACNTTGA

AGAACNTGGGNCANCAGACCNAGCNNTTGANNCCANCTTGGCACCANTGNTTGGACNNG AANCCATGTGGACCAGCTGCCC(^AAGTCTTNNTCCTCACCTTAAATTCCTGCAACATAAA AANTGNTTCGGTNO^NNNCNACTTGACTNTTTGGNNNNCCCGTNTGTGTTATTCNANC NTAAACTCCTΉWCAGAANTTACCTNTTNTGGCGGNGNNGGGNAAGTNGGGNNTAGTCTT NNNTTCATNGTTATTTTNCTTNCNTTNNATTTTANTCN^

NTTNTTTTTNGGNTNTANAGANNNTACANTNT(^TNNNNCGATTN

NTNNCCCNCTANNTNGGAANGNNCCCGNNCGTAN^

NCTNTGNGTGNAANANCC(^CCNGAAATTNCTTTTTAGCCGGCACTCNNNTTNACTCNAC TTTTTANNNTCATNTNNAA(^(^TCGGN SfATANNNTGANATTNTCTC GTNTCTCTCTNACATTNGTNGTTCNNNCG

TGAGGCCNNNTAGTGNNGTCGTATTACNGGGGCGGCCGCTNTATAACTAGTGGATCCCCC

GGGCTGCAGGAAATAACTCTGAGNGGTTTGCCCTTAACTTCTNCAATGNATGANAGTGAA AAATNTAGTTGCTTAGCCGCTCANNCGTGNTACAACTCTTCGGNGACACCATGANCTATA NCCCAACAGGCTCCTCCGTCCATGGGACTGAANAATCCTGNAGTTTANACCATGAAGAGG CACTNNGGGACAAGCTNNGTATCTNTGGNCTGATNAAANGACCATGCGNAAGTGACTNTG GAACTGGNTCNGNCCAATNGCTTCCTGATGCTTGCCANNNTCCNNCCTNNCTNGNTTGGA

TANTCTCNGNTGAGGAATCANCCCAGTNTTGCNCTCCTTGGGCTTGNTACTNGCACNATGA GANATNAGACCCTANATTGGNTTGACCNNAGATCCGTNNGNAACACANNTNGACNTTGA AGAACNTGGGNCANCAGACCNAGCNNTTGANNCCANCTTGGCACCANTGNTTGGACNNG AANCCATGTGGACCAGCTGCCCOSIAAGTCTTNNTCCTCACCTTAAATTCCTGCAACATAAA AANTGNTTCGGTNOSINNNCNACTTGACTNTTTGGNNNNCCCGTNTGTGTTATTCNANCAA

NTAAACTCCTTNNCAGAANTTACCTNTTNTGGCGGNGNNGGGNAAGTNGGGNNTAGTCTT NNNTTCATNGTTATTTTNCTTNCNTTNNATTTTANTCN^

NTTNTTTTTNGGNTNTANAGANNNTACANTNTCNTNNNNCGATTNTTCCNNCGN NTNNCC(^CTANNTNGGAANGNNCCCGNNCGTANATCCTCTACNCTNCTTTNNNCTTTNT^ NCTNTGNGTGNAANANCC(^CCNGAAATTNCTTTTTAGCCGGCACTCNNNTTNACTCNAC

TTTTTANNNTCATNTlNlNAAt^CNTCGGNNATANTSINTGANATTNTCTCGCTC GTNTCTCTCTNACATTNGTNGTTCNNNCG

TNNNNAAANNCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGATATTCGCCTCCTGGCCATAGTCCGCGCCGCCTTTGAC CAGCGGATGAAGACGTGGCAGCGCTGGCAGGATGCTCAGACCACCCTGCAGAAGAAGCG GGAGGCTGAGGCTCGGCTGCTGTGGGCCAACAAGCCGGACAAGCTGCAGCAGGCCAAGG ATGAGATTGTAGAGTGGGAGTCTCGGGTGACTCAGTATGAAAGGGACTTTGAAAGGATTT CAACTGTGGTCCGAAAAGAAGTGATACNGGTTGAGAAAGAGAAATNCANGGACTTCAGA

AACCACGTGATCCAGTACCTCGAGACACTCCTGCACTCACAGCAACAGCTGGCTAAGTAC TGGGAAGCCTTCCTTTCTGANGCAAANGCCATCTTCTAATGGACCGANGACACCAAAGCC ACCTGCCTGACGCTGCCTTTTATACACTTGGCCTTCANCTTTGNCGGGCCCAGNGATGCAT TCTGGCTAACCTGGANTTAACCCNTTNCTTTCTGGCCCCACGAACGGGCTTTGCCCAAGTN TNTTTTAACCGGTACNTTACTTAACTTTCATATATATTTTTCTTACCTGAAAGGAANAANTT

TTTTGGTTTTAAACCAAAAATNCCTNTACTTAGGGGGGGGGNAATAANGGGGAAGGGGGG GGGGGNTTTGGGTTTTAAATTTTTTTAAATCCCCAATGGTTTTT^

GTTAGGNAACTNGGGGGANAAACCNTTTTTTTNTTACNTCCCTGACCGGGGGCCCTTGAA AAAAAAATTTTTTAAANAAAAAAACCTTTTAAAAACN^ NNNNAAAACCTTNGGGGGGGGGGGCCCCGGGGCCCCCAAATTTNCCCTTTTTANGGGGGG

NNNNNNTNNNNNANNNNNNNNNNNNTSINN^

ANAAAACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGGGCGTNGCTGCTCCTTGCGCTGTGCGCCGCAAGCGCCCGGGGG

CTTTATTTCCACATCGGCGAGACCGAAAAGCGCTGCTTCATCGAAGAAATCCCCGACGAG ACCATGGTCATCGGGAACTACCGCACCCAAATGTGGGATAAGCAGAAGGAGGTCTTCCTG CCCTCGACCCCCGGCCTGGGCATGCACGTGGAGGTGAAGGACCCTGAAGGCAAGGTGGTG CTCTCCCGGCAGTACGGCTCAGAGGGCCGCTTCACCTTCACTTCCCACACTCCTGGTGACC ATCAGATTTGCCTGCACTCCAACTCTACCAGGATGGCTCTCTTTGCTGGCGGCAGACTGCG

TGTGCACCTAGACATCCAGGTTGGGGAGCATACCAACAACTACCCTGAGATTGCTGCCA GGATAAGCTGACGGAGCTACAGCTCCGAGCCCGCCAGCTGCTTGATCAAGGTGGAGCAGA TCCAGAAGGAGCANGGATTACCAAAGGGTTTCGNGAANAGCGCTTCCGTCTGATCAAGTG AGAGCNCCAACCAGAGGGTCCTGNGGGGGGNCCATCGNTCAAACTGTCATNCTTNATCCT TCACTGGCATNTGGGCANATGCGTCACCTTAAANANCTTTNTTTGAAGGCCCAANAAAGC

TGGGNGTAATGGTCCCTCACCACGTGAATCCTTTTCTTGGCACCCTNANNTTANTTTGGGG ACNTTTCCCCCNCCCAATATTNTTATTCCCCCTGGGATTTNTGGANGGGNAAAAAAAAAG NGGAAAAAAAGGAATTTTTNNCCCCCCTTTGGTTTCCCTTGGGCAACCNAAAACATTT^ AANTCANCCCCCNTTGGTTAAACCCTTGGGNTTTTTAAAGGGAACCCAGGGNAAACTTGG GTCCCAGGGNTTTTAAAAAAA

TNNNNNNCANCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGAATCTTTATTTTTAAAGCAAAGATCTGAAAAGTTCCAT AAAAGTAGTATCTTCTAATCAATGATTCATTATTAGCAGATTATATTTACTCCAACTAATT ATCCAATCAGTAGTATACTTTGATATATACACATCATACTGGTACCTTGTAGACATTTAAA ATACCTTTGATTTCAACCATGCGTAAAAAAGTAATAATATAACTCCACAAACGTTGCTCTG GAGTACAACGTACACCTCCTGTGTCAGACTGACACCAACCTTCCACTCACCTGTTGGTACA

TGTTCCCACCATGATTTCCACACCCTCCTCTCTGAGCCTTCCTTCTCTTCTCATTGCTTTGAG AAGTTCAGAGTTGTACTTCTCAAGTCTGTGGTAGTAGTTTTGTGGTAGGGCTTTAATAGCA TAGTAAAGATTAGGCAGGGTCAAAGTACTCGGTTATGCCTTCTGATTTTGAGAATACATTG AGATTCTTTATGCCATCTCATTCGNGGCAGAACGGGGCCTCTCATAAATTTTTTGTTTTATT AAATTTAAAGAAAACTACAGTAGAAAATGTTGGCAAGCCAATTATATAACCAGGGGTATT

TATTACTGGGTAAAGGGCTTTGGACAGTAAAACCATGGGTCTGGGTCTGGCACATGTGTT GGCANAANGGGGATAGCAACTATCANTTCGCAATTCTACCANTTTTTTNTTTNTCGGGGNT NTTTTTAAACCATAAAGTAAACTTGGCCCAATCAAGAAAAAATTNTTTTATGGAAAACCT GGTNCCTACCTNCCCCCNTGGGGAAAAAATAAATCCTTANGAAGGCCTCCTNNTNCAAAG GTTTTAACAAAAGCTTCCNTTTTTTTTTTTGCCTT^^

AACAANACTGGAGCTCCACCGCGGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGATTCGGNACGAGGCCAGTTTTCAGTTGTGTACCAAGGATGATTGCTTCAGNGGN AATATTNAGNCTTCNNCTACCTANNCNCATANAANTTTNATNANANNGNAANTANACAAT

TTGANAAGGANNAATTGAATTAGTTAATTNNNATNANAGNNTTNTTTCANCATNATGCAT TGTNCAN WCATAATNTTTTNGTACTTATAATGATANTNTCATNATAATNGNTNAANTNNG NNANGATGCANAAGNGNGNTGAATTOS1NTNNN NAANGGANTNGTAGAGACNTTTNNNT ANAATATNANNNTGNCATAANTNCTCNNNNNTANTNATNNACNNTGNTANNTANTTGAAT GGTTATTANTGGTGNCNTTTTNTTGTAAGNCAAATGNAAATAATNTTNTCATTTGTTTCTG

NTNTATTNTCTGTNANAGACTTNNTGTC^

NNTTTGOSrCCCCCCCCC(^CCCTAATTGTTAACATATTNTTNAGTNTNGATTTTNT^ CTAACNCTNTTANATTNTATANAATAAATAGNTNAAGNNANTNTNTTTTTTNNAGAGNTN NNGNCTNAAGANAGTTTTGGNTCANTTGGGNNNAGATANTGNTATTNGNGANNNNGANT CACAGTCTTNGGATNNGTTATNANATNTTTANANANATTCTTTATTGTNATTAATANGANA

NTAGANAANTTTGATNCGTTAANTTTANTCGTNNCAC^^

ATNTNAGTGNGNTATTANNTATNTNGAANTANTAGNAAATANTTGANNTNNGNNTACGAN NTNATNANCACNTTTTATNINTGNTTGTAGACANTATGTGTATTTAATTAGGATNCNTGNAT AATTATANGAGNCNAGTTNTTATNGAAGNTNATGNTNGTNTNTNANTTNCTNTATTATATN AANATTCTAATTTATCTNCNNATGTNTAGTATTANGANANGGTAGNAGTANGTGTTGAAN

NG

GNGCHNCCGGNTTNNTTTNTNNNNNNNNNTTNTN^ NCACCTTNTNCCCNTNGNGNNANNNNGNAATNNATANNTTNACCCTNANGANCGNATAC

AGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGNAATTCGGCACGAGGGT TTTCTCACCTGAAAGGACTANTGGATTTNCACTAANGTCTATAGACTAAAGGCCATCCTGA TTTCTAANNTCCCCTTCNCAGTTACCAGNGGTCTCTCTCTTTCTTGCNGTCCCTTTCTGCCT CCTGTCCCACCTGTATATGTGTTTAAGGNAGAAAGCTATGTTTTGGTAAGGANAGTNNTTG NACTGTANCAGCTTACCATGGACATTCTTCTNNCAGNCCCANGCACCCACTACTAGTACA

GCATGAANAAACNGCCTACCCAGAANGAGCNGTGGTTTGAGAGNGCGAAGGCCTGGGGA ATTTCCCCACACNCCAAAAGAANACTCTCATTCANCAGCNAGGGACAACNGNTATTGCNN TGGNCTCACAGGCAGACTTTGGCTCGAAAATATTCTTCGNGGTGTTANAATTGCCACNGC ATTTANNGACANGTGAACNANGANATAAATCTGNAAGANTAATNTTGTCACCAATGNACT GTTNCCAGGNNCTCTTNANTNCANATGANCCNATTGNGATNGCCACTATNGGNTCACTAA

NNG(^C<-^TTCC<^TTNACTITGGNTCAAT^^

CCAGGANCCACCANNANTAGGGAGTAANCCANMSfTAGCAATTNTTTNCCCTTTGNCNCCG TGGNCAANTTTTTNGNGATTCNTAATNGGNNCNGGNTATTCCCCCTGGGGGGNANNANTT GTTNCNAANNAANNNTTO^NNACTCTTAATAATACANNTNCTNCCCGT(^TCTCTTTCTGN CNGANNGGANTCCNNTCNTNTαSINNANATCGGNATGGNNTTCNATNCCTTNTNCNCANCA

A( WCTTNTTTTT(^ANGCACTANCNGσS[GNNCTαSlNGGTATAATAAANAGCCT^^

NGTC CNNAAAACCNCCNTNNANTNAGT^

TTATTTNTNAGNCAGNACTTCGTGATCTCNNTTAGANCTCNCTCTTNCCCCTTTAGNGTAC

NCGCGTNCNNCATATC^CGATANACACANα iTGTCCTNCAGNGATAATTANGCNNCTANT

TTCGACGTTCTTCTANGNATACCNTANAGTAAC(^ANTNTANATTCNCTCCTCTCGATCNC

TTTTCANTCCC

GCCCTATANNGAGNTGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCGGGC

CTGCNGGAANTTCGGCCCGAGGGAGAAAGGTTCCTGAAGCTTTNGGNTTNTCGCGGCTGA GTTAGGGATTCAACTTGCCACCATGTCGANCAAANGAGCAAGGNCCAGGACCACCANAA AAGCGCCCCAAGNGCGCNAACCTTCNAACGGTGTTCCCCNTTGTTNNNCCATNCCNAAAT TCAGNANTTNAAGGAGGCCTTAACΗNTNANNANCCAAAN(^GGGTNGGGTTNNTTGNCA AGGAAAACTTGCNTNACNGNNCTNGNTTCCTTGGAAAAAAATCCNNCTGNNNANTTTTTG

NATCCCATANNAAACANGCGTNCCAGGNCCCATAAATTTCCNNGTGTTTTCACANATGTG TTGGGGAGAANTTTNATGGGGCACATCCCCAAANATGTGT(^GAAAAAGCTTTTGCTTGN NNTTTTGAANAAAAAACCTTGTGGCNCTTNTTGGAGGGATNATCTCCTGANAACTCTNNN CCCCAATGGNGGGACCCCGTTNNACATTATGAAAGTTGGGCCCACCTNTTTCACAAAAAA

TTTTTATNGNGGGGANACGGAACNAANACCGACTTANTTNNNAANTTTTTTTTTTCCTCCC

NCCCCTATITSrGGGNGNCANCCCNNTTTTTTNTTNTTAAAAACCGGAATTTNGGGGNCNπ^ TTTTTTTTTTNAAAAAAAAAAAAAAANAGGTTT^^

TNNNTNCCCCCCCC INNTTACTTNGNTSINNTNNNNNNNNNCACNT^ NNGNNNNTNNNNCNTNTNNTTTTTTNCCCCTCTANTCNT^^

NCGTNAAGNGGCGNNTGNT(^TNNCCTACNCTCCTNTNCTGNTTNAGCCCTATAGTGAGT

CGTATTACAGGGGATTNCACATCCACNCNGGCCNNNTCCCCTCTNTCTTGCTCNCCNNTCT NONINCCNTCNTTCGATTTTTTTA

TTCTCCTGCNCACCTANCTNCTTCTOS1NTTTNCGCNCTATNTTTCACTACCATTCCNCNNGC NCTCaSfCGCNNGACCTCTCATNGTTTCTNTTTCOSfCTNTTTTTCCTNTTTN TNGNTCCANTCTCNCCTCTTTTANTNATATNNNGCCNCCCGNTGTTNTTNNTCNCNNATNC

ACTNTCTNCCCOSrCCTNCTNCNCTTTTTTTTCTNTCNATCNCANGNTCCCNNCANCT^ TCCTNTATCNTNCTNNNNATCCCTCNN^

NCACACGTCNNTNNNTTTNCTTCTNCACTNGAACNCCNCCTCTCCCNNTCNCTCCCNTNAC ATCTNTTGNNr^[NNNTTCCTNGAANNCACTNACTCTNTCTTCTCTCCTNTCTATGANCCCNC CNCNGCNTTCTTTTNTTNTC(^TATNTCTNNNCCCTNNTCNTACCCTCCTTCCTNTNπ

TCNTTCNCCNNNCCCCTCTTT(^CTNCTN(^TCNNCTCCTNNNACNCACNTAATTα^GCCC CCNTT(_^CGCCTCCNTCGTACTNTSINTCTTCATCGCTANNGTNTCCACNNTANGGGCCNGTT NTGNATNATCGTCGTTNAT<^TTTNCCGCHrGNC^^ NTCCTACACNCGCTTACGCCNNGCNCGCTCNNCTCNTNCTCCTCTANTNGCTTCCGNTTCG CCCGCTCTTCGGCGNACCNCCTTCNGCCCTNCTNTCTTTATNTCTTAATCTTATTCAλNCNA

CGNTNNCCGTTNNTNTCNCCCTNNTTTTTSTTANTT(^TCANNCGNTCCGGCNCNCGCNCTπ ACTNTCTCTTNCCCCGCACNNANTCCTGCNTCCCGNCNATNTCATTTANTTGCNTNCATCC NNNCNACTNTNTGTCCTCTCNNTTCTNNCACCNNNGTATCCTTTCANAN(-MrCTCNCα^CG CTCT(^TCNTαSπSfCNCTNGNTCTCTNCTACTNTNCTCNTCNTTCTCGNNTNTCTTNTACC TNTGCACTCCANTNTNGNATNTATACNTNCTATTGCCTNCTTGTACTNNTTTCTNNCCNCCT

NNTNCCCGCANATCNACCTNTTCNTATCNTNACTCNCNNNATCTTCTNNACCNCNCNAAN CTCTNNTN<^GTGTACTCGCATNTACCT1S^^ GNGNCTCTCCATTTCCNNCTANGNNTCTNCTCNACTCTNTCCTCNNNCGTCCG

TTGAGCCCNATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCAANCAACACTGNATGGGTNCCCNTTNCCTTGCCNANTGTNTGACAGCGAN GAATNATTGTNCTTAATNGGNCAGNGNGCCNNCAANNGCNNGNNNTCAACNTTAANTAC AGGGNCANTANNACTTCAAAGNNCCNTNGCANNCCAAAANCCCNGCACCTTATAACCCC GANGGAGTNACNNCOSINA(^TG(^GTGGNCNNATTAGCTCTGGANCCANGGTGAGNCCT NGGCCNAAGGAGGGCTTTAGATCNNNNGGGGACCAANTGTGCNNGNGATCNCTGGGACA CGGCTCGCACCCTTTACCTTAGANTGGAGNGTCTTATCATTTNANGNGAGTATTGNNANAT AGAAGCTCTNNTTGTGCCAGATCNANGGCACATATNCTNNTATTTATCCTCNAGANGNGN TGNCTCTTTNCNAATGNGGGGAACTNGAGNTNTACTCNGGNTACANTNGNACNTNAGNCC

CACGTANNCGCACACCNNGGGNGAANACAATNTTANGGACACACANANTANACTTNTNT TTGGGNACNNCNNGNCTGGNNTNANGNNNANTAAANANGATNGNTTGCTNAACTCNTAC AAANTAANNAANGTNCTTNTTNGGGGGACCNNNANGTN^ AGAAAANTCAANCTNTTCCCCCATAANNNCCANNTTTNCCCTCTNATNANACNCTTTTGGT NTTAANGGGANCCCCTCCNATCANNATGGGGNACCANC^GTNNTNGANCCNNTGGNCNC

GNNNNCCCπsiTNNNNCANNAGACCAANCAQtNNCNTNCATGGCAAANNNGTTACATGNTN TNTTCNTANCTCTCTNACNTTNTCA^

TTNCATGTNTNTTCTANNANGNTANACACNANNAAANTNNNTTOSINTTNAAT^^ NGCNTACANAATNCGGTTCCTANNTNNAAAANNNTCNATANAATTCTNACCNNCCANCTA NNTATTNNTNCGAANTNTCTACGANTNANGANGNANCGACCG

TTGAGCCCNATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCAANCAACACTGNATGGGTNCCCNTTNCCTTGCCNANTGTNTGACAGCGAN GAATNATTGTNCTTAATNGGNCAGNGNGCOWCAANNGCNNGNNNTCAACNTTAANTAC

AGGGNCANTANNACTTCAAAGNNCCNTNGCANNCCAAAANCCCNGCACCTTATAACCCC GANGGAGTNACNNCCNNACNTGCNGTGGNCNNATTAGCTCTGGANCCANGGTGAGNCCT NGGCCNAAGGAGGGCTTTAGATCNNNNGGGGACCAANTGTGCNNGNGATCNCTGGGACA CGGCTCGCACCCTTTACCTTAGANTGGAGNGTCTTATCATTTNANGNGAGTATTGNNANAT AGAAGCTCTNNTTGTGCCAGATCNANGGCACATATNCTNNTATTTATCCTCNAGANGNGN

TGNCTCTTTNCNAATGNGGGGAACTNGAGNTNTACTCNGGNTACANTNGNACNTNAGNCC CACGTANNCGCACACCNNGGGNGAANACAATNTTANGGACACACANANTANACTTNTNT TTGGGNACNNCNNGNCTGGNNTNANGNNNANTAAANANGATNGNTTGCTNAACTCNTAC AAANTAANNAANGTNCTNTNGGGGGACCNNNANGTNCNTTTNNCCAAANTGTCNNNNTG AGAAAANTCAANCTNTTCCCCCATAANNNCCANNTTTNCCCTCTNATNANA(^CTTTTGGT

NTTAANGGGANCCCCTCCNATCANNATGGGGNACCANCNGTNNTNGANCCNNTGGNCNC GNNNNCCCNTNNNNCANNAGACCAANCACNNNCNTNCATGGCAAANNNGTTACATGNTN TNTTCNTANCTCTCTNA(3NTTNTCANTGGGNTCNTTACCNGTTTNNNNANCTCNTAGCACN TTNCATGTNTNTTCTANNANGNTANACACNANNAAANTNNNTT(^INTTNAATTNNGNGGA NGCNTACANAATNCGGTTCCTANNTNNAAAANNNTCNATANAATTCTNACCNNCCANCTA

NNTATTNNTNCGAANTNTCTACGANTNANGANGNANCGACCG

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCCCAAGTTTTTTTTTTTTTNAAATCCCAGGCTTTT^

AAAACATTNGGGGGCTTTTACTGANGGTTNTTAAAATANTCATNATAGNANCTGGATNNG

TTTTTL NAAAGNANAGNNGTGNTTNCCNGGNNCCAAAACCAAANNGNTAATΠ NNTTTTAAAAACTTTNNAANTTACNANAAGNNANTGNAAAAAANCCCTTTGNTTGGCCTT TAAAAANCTNCGNTTTTTTNAANCCCNCCNATTTTNAANGAANNNNT^

AAANCCCNAGGNNGNTNNGTTNCCAAAATTNNTTTTTNNCTGGNCGGGTT^ NAAACCGGGGAAAAAAGNCCGTTTNCCTGGTTNNNTGGGNCCCACTTNNTGCTAAAANNA AAGNCCCTTGGGGNAATTAACGGGACTGGTTGGCATTTNGTGGGAGGGGAGGAAAAACN TTTTTTTGCCCAANGAAAGGAAAGGCCCAAAAACCCC^TGGAAAN^ ANGGCCCGGAANCAAAACCCNCCNTTTTAANCCCCCGNTTTTTTNCCCCTCAANGGGGGA

TTCTNAAATNTTTTTCNGGAAACCCCCCTTTGGGGGGTTNCAAAAGGAAAGGGNNGGGGA NNCCCCCCCNGGGGGTTTGGGGTCCCCCCCCCCCCCTTTTNAAAAGGNCCCAAAGGAANC CCTTTΠTITI^CCCCNGGGCCCTTTAAAAAAAAAAAAGGGCCCCTTT^ GGCCCCNTCAANGGGGNGGGGGGGGGGGGCCCCCCCAGGAAAAAAAAAAAAGGGNTTTA AAAAAAANGGGCCTTTTTTTCCCCCCTNNGGGGGGNC

TTGANCACAATCTGGAGCTCCACCNCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATNC NCACNAGGCCCANCGNNNCTGTNNNCCNNANGGCTGNGCCTTTG GGGAACTGGAANCNTTNNTGGGCNTTNNACNNANGNGGNANTNACTCATATNCNANNNA TGACTGGNANCGNCCANNNTTTNTNAC INTTNNCNAAACATCTGNGCTCCTNTAACTCAC CΉNGGNGCTNNCGGTTTNTTTTTGNATNNAACGNTGGAGAANNCGTANGCCNACCAANCA TACNNTTNACCCANNNTTTTTGAAANNTATO^ TTTTTGTGNACNTTNANAATNAC^^

ATGNGANTANTTCAAGCNNCCCGGNGAATTCCTTCNTGAATGTGGTNNCCACCCGCCTAA GANATGATGNAGGGGNANCNGGGNAAAAATNATCATANTCNGCAGNGTNAGAGAGGGCC ΑSFTTGGGTAAAATANTAATAAGAACCNTTGNTCCNTTATCCCCAGCCGACTNTNNTTTTNT TTGGAGCAGAGAAAANAATNTTTTTTTANNGCANNCTGGTGGGGGGGGACCCCANNCCCC CCTTGGAAGGGAATGTCATTNNTTANACGNAANNNCNNCCCACTTNCCCCTTTTTTA

CCOSFTTTGTTCTTTCCCTT WAAAGGNNNGGNGANCCTTAAAGTTT^ TTTCATTGGGGCTTAAAAAAGGGAGGNTTTGGGGTGTCCCAANCGNAAGGGCNCGGACNC CCCCCNCCTTTAAAACATTTNNAAAANGGACCCCGGTTTTNTNCNNTGCCAAGTTAAACNT TAANNNTTTTTTGNTCC(^GGTTTTCCACAAAAAGGGGGGGGGGGGNNTNACΑS^ TGAAANAAAGGGTTΓTTANAAAAGGNGTCTTAATTTCCCCTTTCNNNG

TTGNAANAACAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCC CGGGCTGCAGGCANCAACCTCTAGAANTNACCGTTCCTGCCNCANGCTTCCAACACAGCG NGGGTCTCTCCTACTGCTGGAGGNCTCTGCCCTCCACATCCTCATTCTCATCCTGCTNTNCN

TGGCCACTNTGGACAAGTNCTGGTGGACTNTACCCGGCANGGNGTCNCTGANTCTNTGGT TCGACTGCNNNTGGANTAGTGACNNCANAACGTNGTCCTTCNATAACTNCACANACATCG GTTNGNTGTACACAGTACACCTCCTGNNTCAGATTGNCCNCATCCTNTNACTCNCNTGCTN NANOSfTGTrCATNCCANAANTTTNNNNCNTTCCTCTANGAGNC^TANTTCNTTNCTCATGT GCTTTTGACAAGTTCAGAGCCNGTACTTCTGAAGTCTANNGGTANTACTTATCGTAGGNCC

ATTTCTTTNNTAACATAATNCTNGATNAACCCGCCCCTTCAGGAGGGGGCANGGTTTANG NTACTGGCTATCANCCATGACNCCGGGTGGNGACTTTNTCCNTNCGCCNCTGGACCANGG GGGNATNATNNGACNCTCNCNCCNATGNAGNAATTCNNGGAAGTTATGGAACTTGTNCCN TAACCTNTNGAATNNCCNAANANCGAATTNCNAGGNCCNNTTTNTTTTACACCNCGGANA NCCNCCCNACCCGTTTNCTTNNTTTT^

NCCCC^TCCGAAAAAAAAAAAAAATANNATNTTTTGGCNCGCCCCCCCCCCCCCNTCCGT TNCGTCTTNTTGNGGGTNTATTTNCCNANCANCNNCCANTCNTCNTNAATTTCACTCNNAA ATCTCTTTNTTTTTAANOSfTTTTATTCNCαSfTTNTTGπ^ NTCTCTTTCTNNTNTCNNGNTTAC^ TCCNCCANACNT

NACAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGCTCCTCTCCAGCCTCCACCATGTCCATCAGGGTGACCCAGA AGTCCTACAAGGTGTCTACCTCTGCCCCCAGGTCCTTCAGCAGCCGCTCCTACACCAGTGG

GCCCGGCTCCCGCATCAGCTCCTCGGCCTTTTCCCGAGTGGGCAGCAGCAGCAGCTTTCGC GGCGGCCTGGGCACCGGCATGAGCATGGCTGGAAGCTACGGTGGGGCCCCAGGTTTGGGG GGCATCACAGCTGTCACCGTGAACCAGAGCCTGCTGAGCCCCCTCAAGCTGGAGGTGGAT CCCAACATCCAGGCCGTCCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAACAA ATTTGCCTCCTTCATCGACAAGGTGCGGCACCTGGAGCAGCAGAACAAGGTTCTGGAGAC

CAAATGGAACCTCCTGCAGCAGCAGAAGACTGCCCGGAGCAATATAGACAACATGTTTGA GAGCTACATTAACAACCTCCGTCGGCAGGCTGGAAACTCTGGCCCANGAGAAGCTGAACT GGAAGTGGAGCTTGGCAACATGCAGGGGCTGGTGGAGGACTTCAAGACCAAGTATGANG ATGAAATCCAAAAGCGCACAGACATTGGAGAATGAATTTTGTCATTATTCAAAGAAAGGA TGTGGGATGAAGCCTTACATTGAACCAAGGTAGAGCTTGGAGTCCCCGCCTGGAANGGCT

TGACTTGATGAAAATCAACTTTNTACANGCAACTGGTATGAAAAAGGAAAATCCCGNGAN AATGCAΛTTTTCAAAATTTTTGGAACCCGTTCCGGGGGNCCCTGGGCCCTTGGGNAAAAA NAAACCCGGAAACCTTGGGANCCCGGGATNGGGGAT

AAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGGGGAGTTCAGTCTTCGTTCTTCTGTGTTCGCTGCTGACACCACCA CTAATTGACAATGCAGATCTTCGTGAAGACCTTGACCGGCAAGACCATCACCCTGGAGGT GGAGCCCAGTGACACCATCGAGAACGTCAAGGCCAAGATCCAAGACAAAGAGGGCATCC CCCCAGACCAGCAGAGGCTGATCTTTGCCGGGAAACAGCTGGAAGATGGCCGCACCCTGT CTGACTACAACATCCAGAAAGAGTCCACTCTGCACTTGGTCCTGCGCTTAAGGGGAGGTG TTTTAAGTTCTCCCTTTTAAGCTTTCGATAAGTTACATTGCACTTTTCTTTCAATAA^ TTGCATTCCAAAAAAAAAAAAAAAAACCNGGGGGGGGGNCCNGGCCC(^ATTNCCCCTT ATNGGGNGN(_M fTANAANNNNNTSINNNNNNNNNNNN^

NNNNNNNNNNTSiNTSiNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNN^ NISINNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNTSπSINNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNTST^ NNNNNNNNNNNNNTSINNNNN^ NNNNNNTSπSlNNNNNNNNNNNNNNNNNNN^

GCCTATAGGGAGTTGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGGAATCCCCCCGGG CTGAAGGAATNAAGCNTCNGCCTNTGCGTNGTCCTTCCGTTGTCCGCCAGCCGTCAATGCT CCCNTCCGCGTTGCTCCGCCGNCCGGGTTNGGGGCCGCCTTNGTNNGGCCAGGGTCCCGC TTTTTACGCCAAAGGNTGGCCNGTTGTTAAAGGGCCCCTTGCNGGNGGGNTCCCGGGAAA AAAAATGCCTTANCNTTTGCNTTAACCCAACNAGGGTGTTTTTTAAANAAGCGCCAAACTT

CCGCNAGGGTGGAN^JNNGCCCACCACAAA(^GGNCCNTTTGGAATCCTTNAAACCNATG NGCCCNTTTTGGANGTCNTGNGGCNAGGCNATANTTGGGGCCCACCTTGANGNNGGCCCC CACTNNACAAATACTTTNGAAGANTAGGGGNCNTNTGACAAAAGAAAAATGGAAGACTN CTNNGAANAAAAAANNTGNNATTGAAAGAAACTGACNTCTTTNGNANNNNNGANAGAAT TNTGGGGGGNAAAAAAAAAANACANTTNTTGGAAAAANGCCACAAGGCNGGNTCTTGTT

GGGGGGGCAAAAAAAACGAAGCCCNCTTGGGGGNTANAAAAAACAAAANCCCANNATG GGNCGCCCAANGGAGNTTCTTTNANAAAAANNTTNTTGGGAANTAGGGGGGNTTCCNTNC NAAANAACTTGGCCCAGGGTAANAAAAANCCNGGGCCNCGATNCTTGAGAAAANGGTTG GGCCTTGGNAAAAAAAAAAACCCAACCTTCCCAATGGGNCGCCNNCNNTACCNANNGGA TTCCTTCCCCCCNNGAAANACTGTNCTNNTAAAATAAANCCCATTTNGGGGGNCCNTCAC

NNNNNTTTTTTTTTTTNNACACAAAAAAACTCTNTTT^ TTAAAAAAAACANOStNCTAGAAAACANNACCTTTTTTTTNTATTCNN^ GANGNANAAATNTANNAACAACTTTTCCCCCKt-^NAAAAAANAAAAANANCTCCCCNCN GGGGNGGGGGGTNTTNTTTNNNNATAANANANNATTTTTTTT^ NTANAAAAAANCT

GGNMSfANGGGNGCGCGNACGTCAGCCACC(^CNNNCCNTTNNAGCCCNATAGTGGANGT CCGTATTAACAAANNNATTACANNNNNCCCCCNGTNTNCCNCNCCCCGTCNCTGCCTCCC CTCCCTCCACCCCNCTTTNNTCCNTNCGCCCNCCCCCNTCNTGNNNCCNCNCCCGGNGTCC

CCNCCCCTCTNTCCCCTTCNTN(^ANCNCTTCTCNGNACNNCACGGNNCCCNCACNNGCC GCNTCNCTCCCCCCGGNNCCCCCCNGCNTGGCCQINT^^

(^CCTCCCGCCNNTNTNNGTTCCCGNNNTNGCTCGCGGCCCNNCCCCNNTNTATCTTCNCN TCNCNCCGGCTCNCCCCCCCCCCCCTCCANCNNTNGTCCGNANTCCGNCGNCCCCNCCGTC TNATNCTCNTCTTNNANCCTCGNACNNTCGOSfNTTGGCCϊWCGNNNTGGNCTNNTGNCCA

GCNGGCTCNTATNANTNNCCα INNCCGNCNGCCCGGCTCNTCCCGGCNNCCCCCTTCCCN CCCGCNCCNCTTCNCGNCACCCCGCTC(-MNNTGGTGNCTTNCTCNCGGGGGGGGGGGCCC CCGACTTTTCACCTTCCGGGGGGTCGCCTCGNCNGCNNANNNCNNGCNCTACTGNNNNCC CNCNACCCNGNGCGATCATGCANCTCNNCNNTCCAATNTCCGGNGCCCNCGANGCGNGCG NCNNCGCCTGGTGTGTNGCCNCCTCGCGNCCCNTCTNACCTNCNANCTCNGGTTTCCTCTC

NNCCNCNNNCGGCNNCTNTNGNCCCACNNNTACCTTCGGNGCNNCNNCCCCGCCCNTCCN CTOSfNC(^TCTNCTTCAGTCCCGTTNCCNGCCGCCANAAGANGαS[GTGAGCNCCTNCTCN CCTCTNCNNCTOSrGTNNCCTTATGCTC^TTNNCCTNCCNTANαSINCCNCGGCGNNGNNNC NNCGACNANNACTNTTTTACANTNNCNGANTTTCCGNGAGGNANNNCTCACTNCCNNTCC NNNTCTNCGCCGNGCTCTTNCCMNCGCNTATNCNCNGCNNTNTCCATGCTCCGCNCTACCC

GCGCGCTNCACCCATCCGNNGCGCNNCTCGCCGNCNNCCTCGTCGNCCNTCCCGNCGNCG CTTNTNTNTNCCNCTNTCCNCTNCGCGACGTNCGNCTNNTGCNGTCCACGCTCTGACCGCT CTCTTACNNGTGCGCGCNCANNGCGCACATNCACGGGTCCAGNGCCTAGTNCGNGCNTNC GCNCNTCTNCCGCGC^CGTCAΑWACGGCG(- (^CTCTTANNCCTNCANCCGCTACGTTN GCGCCCTCTNCGTTCGCCNCTTACTCGTCCCG

TTTNAGCCTATANGGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAAANAAACACTGGAGTGGGTTGCCATTTCCTTCTCCAATGCATGAAAGTGA AAAATAAAGTTGCTTATCCGTTCAGCCGNGTCCAACTNTNGNCNACNCα TNANTTNTAN CCCNCCAGGNTCNTCCGTCCNTGGAANNNAAANTNCNNGCNGTTANTCCNNTNAAAAGG NCCCCNGNCCANNCTTNGANTNTGGTNNNNANNAAAGNACAAGGNGNANNNNNCNTTAA MSTTC ITTNNA^ANNGCNTC^^

TTAAGTTAAGNATTAANCCAANCTNGTTTTCTTNGGCNTGGAAACGGCACATGAGAAATA AAACCCTTAATGNGGGGANACCAATCCATGTGTGGAACCACTGTGACATAGAAANTCTGG CACACACACCAGCATGANAACCCANTGNGGCANNNTGTNANACAAANNCTGTGCCCATG TGCC(^CAGTCNCACαsπ^ATGNNNATTNTGCACAAAAAAGGGNGTGTTNAACCCCNNTGA TTTGGGGGGNCTNGGTATACACCANTANNTCTTNNNACAAANNATATTTTGGTGGNGAAG

NGNACAGGGGGTTTCTTATATAATGGTGNAATTTTTCGAAGAATTAATACCGNTGAATNG GNGAATAAAATNTTATGNGTTTTATTAAAAAAAAAAAAAAAAAAACNCCCGNGGANATA

NTTTACCCTCNTTTTTTGGAAAAAAACNCNCCNAAAAAACCCGTTTNGGNGGA^ GGGGGGTTAACCTTNGGNAAAAAAAAAAAAATTOSrAAAAAAGNGNTTNNNNGCGGGNAA

AAAACCTTTTTCCAAAAAAGGNNGAAAN

TTTNAGCCTATANGGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAAANAAACACTGGAGTGGGTTGCCATTTCCTTCTCCAATGCATGAAAGTGA

AAAATAAAGTTGCTTATCCGTTCAGCCGNGTCCAACTNTNGNCNACNCαSfTNANTTNTAN CCCNCCAGGNTCNTCCGTCαSfTGGAANNNAAANTNCNNGCNGTTANTCCNNTNAAAAGG NCCCCNGNCCANNCTTNGANTNTGGT JNNNANNAAAGNACAAGGNGNANNNNNCNTTAA NNTCNTTTNNACNANNGCNTCNNNNNNNTGGNANCNTCNACCTTNANTGGTTGGAATCNT TTAAGTTAAGNATTAANCCAANCTNGTTTTCTTNGGCNTGGAAACGGCACATGAGAAATA

AAACCCTTAATGNGGGGANACCAATCCATGTGTGGAACCACTGTGACATAGAAANTCTGG CACACACACCAGCATGANAACCCANTGNGGCANNNTGTNANACAAANNCTGTGCCCATG TGCCCNCAGTCNCACαsfNATGNNNATTNTGCACAAAAAAGGGNGTGTTNAACCCCNNTGA TTTGGGGGGNCTNGGTATACACCANTANNTCTTNNNACAAANNATATTTTGGTGGNGAAG NGNACAGGGGGTTTCTTATATAATGGTGNAATTTTTCGAAGAATTAATACCGNTGAATNG

GNGAATAAAATNTTATGNGTTTTATTAAAAAAAAAAAAAAAAAAACNCCCGNGGANATA TTTACCANCNTTTTTTTTTTTTCCCCCAAAAAGGGGCCCCCCNCNNGNNT^^ NTTTACCCTCNTTTTTTGGAAAAAAAOSrCNCCNAAAAAACCCGTTTNGGNGGAATNTT^ GGGGGGTTAACCTTNGGNAAAAAAAAAAAAATTCNAAAAAAGNGNTTNNNNGCGGGNAA AAAACCTTTTTCCAAAAAAGGNNGAAAN

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCCAGACGAGCGAAGGCAGGAACCGTGGNCGTCGGTTTTTTC GTTGGCCCCGCNAANNCC<^TTTNNNGCAANNANGGNCACCGTCCNTAAANCCCGCAGG

NNTTTNTGTANAAGGNGNGGAAGGCTTCACCCTNNCAANGGGNCCCAGTTTANNAGGGCC AAAANTNCCTTGTTTNCCCAGGNAAGGAGGCNTTTTGNTCGGAANCAAAGNGGTTNCGGN GGCCAACCCAANCCATTTTTCCGGAGAAAGGTTAAACCCCCCAAAAGAATCGGCTTAAAC TTGGATNCCTTGAGCCCCACTNGNAAATCCAAAAGGTGCTTGCCNTTTAAAAGNGCCAGC NTTTTTGACTTTGAGGAAATAAAAAAANAAANGGCCCAGTGAπ^

GATTC^TTTTTTCTTNTGTTTTGAGAAAAAAATGGTTGAAGTNCCAAAAAA GGGAATTAATACCCGCGATTTTTCTACTTAAAAAAAAAAAAAAAAAAAACTTGGGGGGGG GCCCGGGCCCCAATTNCCCCTTTGGGGGGGNNNTTANN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNlSINTSπSINTSINNNNNNlSlNNNNNNNN^ NNNNNNT^NNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ ANCAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGTTTGCCNCTNATGGNTNATGCTTGNTGTNCNCANCACTCTNTCNCTCTGTCTANGGC

NNNGACCΉNCNGCNGNCGNAANGCCACNATGTCCATCCTGAAGGANCACGCNNGATANA NTTNTNNCTCTCGTGGGAATCCCACCGACGNGGTTGATCTCTNCACACGCTAAAGGTCAAT

GCNTAGNTGNTGTGCCCAANGGATGCTTCATCTTGGAANGTATGANGCCCTGGGGCTCCG GAACANTGATAAGACTCTCTNCATGGGAAAAGGTGTNTAAAGGGNTGACGACCTCATCAN NAAAANAATNGCCCCTGCCTTGNNTANCAAAAAGNTNAACCNNATGANGCAGGANAAAA TCCCAACCTTANNATAAACTGGATGGCACANAAAATATTNTTGGGGTGCNANCGCNATCC TGNCGTGCCCTGGNTATTTTAANGGCTGCAGCTNCGAAAAAGGGGGGCCCCTTTACCNCC

CATCCCCCACTTTNNTTGCAATGCTTAACGNCATCCTGCCAATTCCGGCTTTTNAATGGCC TTCACCTTAGGNCTNTNANGCTTGNAACCANATTGGGCCNTGCAAGGGGTTTATGNAGCC TTTCCTGTTGGGGGAαSfAAANANTTTCCNGCNAGGGCCTTGCCCCACCCGGAACCTNAAG TTTTTAACCAAAAGCCTGGGAAAAAGGCCNTTNATNGNGGNAAAAAGGGGGGGANGGGC TTTCCCACCAAACGGGGGGNAAAAANNANNNC^GGTTTTTTGNCCCCNAAAATTTCNGGG

NAAAAACCNNAAAAANCCCCCTGGAACCNTNNTTGNAAAAAANTGGCCCNCCCNNAAAA AGGGNGGGGTTTCCCCTGGCCCCAAGGGCCCCCAAAAAGGGGGNAANGGGGGGNAAAAN GTGGACCTTTTGGANNNNTTCAANGGGCCCGNGGNCAAANAANGGAACCCN

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGGTTTGGAGTTTGCTGTGTCTGTATTCANTAAGCAGAT ACTATTTATTTAGGTTGGTGTAAAGGTAATTACAGTTITC ATATTGAAATACATTCTTAAATAAATGAAGTTATGTTTTGAAAGTGCAAGTGTTAGTCACT CAGTTGTGTCTGACTCTTTGTGATCCCATGGGCTGTAGCCTGCCAGGCTCCTCTGTCCATTG

GATTATCCAGGAAGAATACTGGAGTGGGTTGCCATTCCCTTCCCCAGGGGATCTTCCTGAC CCAGGGATTGAACCCATATCTCCTGCTTTGCAGGCAGATTCTTTACTGTCTGAGCCACCAG GGAAGCCCGAGGTTACGTTTTACATCATTTTAATGCACATTTCTCACTTTATGTTTTTπ TAATGATNTATTACTTGCTGNTTATTTTAAACTAGGGAAATGATGTTAGACAAAAAGCAG AATTGAACGATTTTCTTATTTGAGTTCAAAATAAGNCNTAANTCANCAGAAACAACTANC

CACATCAGTGACNCTTTTGACCCAGGACTGNTAACAAACATCCGGGCANTAACCCGTTCA

TNAAAAATTGGNCAGGGACCAACTGGGGAACCCNCCCGGNGGGACTTGAACCNTTTACCA GNTTCCCTNGNNAAAGNNGCCCAAAAAAACTCGGGGGCNANCCCCNCTTCCNAGTGGNTC NNCCNNTTTNAANCCAAATTTTTTANGGGG^

CTTTGAGACCCCCCCCG(^AAAAAAAAACCTTTTTTTTTNNAAGGGGA

TTNNACAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCACCAGCCCAGGCTTGGACAATGGGTGGGGACATGTTCA

ACGCCAGGTTCATTCGAAACTTGCATGAACGTCGCAGCACCAGGCCTTGGTGACCGCAGC

CCCCTCTCACACCTTCAAAATCATTATTATTTCTATCTCACACAGGACTTAGTCAAAGCTTG

CCCTCGCCGTGTATGTATTCATTCATTCATTTATTCATTCTACAGGCTTTTTTTTπ

AGGGCCAAGTCATTNGTATCTTATTTTTAACCAGAGCAATAAAGTATTTTTTACCACGAGA AAAAAAAAAAAAAAAACNTGGGGGGGGGNCCNGGNCCCNANTTCCCCNTNNNGGGNGN

NGTTTNANANNNNNNNNNNN J INNNNNACCTGGAGCACANACAAG

NNNNNNNNNNτINNNN]SπSINNNN^

NNNNNNNNTSfNNNNNN^

NNNNNNNNNNNNNNNN^ NNNNCNNNNNNNNNNNNNNNNTSTNNNN^

NNNNNNNNTSINNNNNNNNNTS^^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNN^M^I NNNNN NN NNNN N ^

NNNN NNN^^ NNNNNNNNNNNNNNNN

GCCNTATNTGGAGCTNNATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCTTCTCTGGTCTCCNGGTCCCCCCGGCCCTCCCGGCTCTCCTGGTGAGCAAGGTCC TTCCGGAGCCTCTGGTCCTGCTGGTCCCCGCGGTCCCCCTGGCTCTGCTGGTTCTCCCGGC AAAGATGGACTCAATGGTCTCCCAGGCCCCATCGGTCCCCCTGGGCCTCGAGGTCGCACT GGTGATGCTGGTCCTGCTGGTCCTCCCGGCCCTCCTGGACCCCCTGGTCCCCCAGGTCCTC CCAGCGGCGGCTACGACTTGAGCTTCCTGCCCCAGCCACCTCAAGAGAAGGCTCACGATG GTGGCCGCTACTACCGGGCTGATGATGCCAATGTGGTCCGTGACCGTGACCTCGAGGTGG

ACACCACCCTCAAGAGCCTGAGCCAGCAGATCGAGAACATCCGGAGCCCTGAAGGCAGC CCGCAAGAACCCCGCCCGCACCTGCCGTGACCTCAAGATGTGCCACTCTGACTGGAAGAG CGGAGAATACTGGATTGACCCCAACCAAGGCTGCAACCTGGATGCCATTAAGGTCTTCTG CAACATGGGAAACCGGTGAGACCTGTGTATACCCCACTCAGCCCAGCGTGGCCCAAGAAG AACTGGTATATCAGCAAGAACCCCAAGGAAAAAGAGGCACGTCTGGGACCGGCGNAGAC

ATGACCCGGCGGATTCANTTTCGAATATGGCGGGCAGGGGGTCCGATCCTTGGCGAATGT GGCCATTCAACNTGANCTTTTCTTGCGCCTTGAATGTTCAACCGAAGGCCTCCCCAAAAAA TTTCACCCTACCACTTGNAAGNAACAAAGNNNGGCCCTAAATTGGACCAACAANACTNGG CAANCTTTAAANAAGGGCCTNGTTTCTTCCAGGGGTTCCAACGNAAANTCAAAAACCGGG CCGAGGGCAANAAGCCCGNTTTTAACCTTAAGGGTTAACCTAANNANGGGTTGACNNAAT

CNNT

TTTAAGNCCTATAGTGNNGTCGTATTACAGNGGCGGCCCGCTCTAGAACTAGNGGGATCC CCCGGCTTGCAGNAATTNGGNACGAGGCTTTTTTTCCGCCTGGNTATCCGAATGGGCCCTG

CTTTATATCACACTNTGCNTAGGGGTTCCNGATGACNTGGCAAACCCCCCTTGTTTNTGGG GCCNTGATNACATNAAGANTTTNNTNGNCAAAANCCTTGNNTTNAGNNANNTTGGACCGG GACACAAANAGGNGCNNTTNGNANNCGGGNGNGTNNTTCCCCNACNGGCNTATAGGNNN NGTGCCATCANNTTNNCCCTATATTNCACCTTANCNCTNNGCTCTNNAAAANAANATGTN (.MSfGGGGTCTANATTTTTNTNAAAAGGGGCACTTNTACCCCTCTCACTTTTGNCTTTπ

ACCAGNGNCAANNGNANGAACCTCTTCCCCCNTCTNAANAAAGNTGGNCNTNTNTCNTNT NNTNCTTGTGCCNAAGGNGGGGAAANANGNTTTATTTCNNNGGNCCNCCAAAANCCTTNA AAAAAANGNGGGGGNCTNTTCTNTTTNNANNGTNTTNCGGNGNGAGAAACNTATGTCCCC TAGAANTATTACTNGANANGGANNTNCTNNNANTCAGCTCNTNCAANNCTNGTTAANANN GTGGNNAGAAANTANANATNCCCTAGGGNCNTANCCANGNGTATGNGATNCANNCTTGN

CTNGACTNTCCCNCANTNNACGGGANNCTNAGAAANNANAANCTNTCGTGNCCCTNGCTC GCGOWTATTANGNNNTCTANNNNCGGAGCCCTTCCCNCNTNTTTNTCNAGNCGTTCCNCT TNTTISπSfTAACTNNACNAAACTTTGCTTCNNNANCCCCACCTNTTNTTT^ A<^CTNNNNG<^ATTGNNCTCCACTNGACOT NNTNTGACTANCCCAGT<^TGAANACTNGCCGCANNOWCTTTNNTTNNNAGATTACCNN

TNGNNGCNNNTGCCTCNCTCCNTATTATNCNTANGNANTNGNNCCNCTAANGACTCCNCN TANNACANCATNGAGTACGNCATTTTNAATCTCTTCGGATNNCNANTACGNNTATCTTNGT TNOWCCNNTCTNGGGCNNACTCNGCCC

TGCNNGNGNNNNNGCCANNTCNCTCMvTNNNNNNTTNNAGNCCNATAGTGGAGGTCGTAT

TACAAANGGANTACACTNCNAAANCGGNGGGGTACCCCCNGANTTGCNCTNATNTTTCTN

CTTTTNTNCTTCTNTTT^^^

NCTTCTCNNNCNNONπSfTCAC NTCCCCTGTTNGTNTTCATCATTGNGTCTNCTNNCTCCNGNNNGTNNGCNAGCGNNCCGTN

NCNTNNCCCCTCTNTNTNATNGTTGGNCTCGG<^^

CTG(^CCCNATGNNTGCNTTNNTTrWTTNTTNNTATTACCGCGNNCCNCNCCNT^

TANTNTTTGTNTCCNCNCCACCGCTNNCTTATATCNNTNNNTGNTCGGCTTTCNNNAGNCA

TNCNAT1S1TNINTCTNTCTNCNATOT TGOSICCCCTNCCCGTαWGTNNTTCTTTTTNTTNNGNNGCGNCTNCCGTN^

TNGNAANTTTCTNGCCATNNGNNNANNCNTTTTCNTNGNNNNTTGCNNNT^

NNCTTNTNTGNNCTCTANGCGGTCN^

NTNNGGCCWGCNNNGNNCHmCT^TGN^

NNNNNNGGTTTGTGGGNNTCCGNNNCNCT^ NNGNCGTNNATATGNCCNTTNININTCATTC^

GTTTTNTCTTNCCCTCCNCCNCTCCC^

GCTTCGNNCTGCANGCAACTCATNNTCNGCNTTATNCTGCTNATTTTCNNCAAGCANTNAT

<^GNGNTCTCC(_ ϊGNTTTTNCA<^CT^^

NNNTCTNGCAT(^TTTGNTNNCTANTNATGGCCANTNTTANNTNTANTATTTT^ TCANNGTATTTNCTCACATATTTCTNCTTTTCTGTTTNTCTTCGCGCTNGCNNTTAGAT^^

CTNCTNNTTNTCCT(^ATNNATNNTTATCNCGTCNTTCTNNNTCATNNCTCT^

NACATCTCACCTNTNGCGCTCTCGTCNCGCGNNCNCNCCC

TTNAGCCTATNTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG CCTGNAGGAATTCGGCACGAGGCTCCCCCCTCCCCCCGAGCGCCGCTCTGGCCCGCACTG CGCTCGCCCTGAGCTCCGGCCTCNTGTTAANCCAGCNCCGTTGNCNCNTCCTTCNAGNCNC NNTNNTNANNNTTNNCCGGANCNTNNTTACCCTTNACAAAANGTNNTCCNNCT^^ AATCCGGANGGNCNNGNCCGGCNTGNNNTNGAAGGGGNAGGGAAAAANGGNNATTAGN

NCAAAGGNNACNNTNANNANNTNCTTNNTNGTGGNAANNNCNTCNGTTNAAGGCCCNAA GGCCAANNGGCNCCAAAGNCACANNATTCTGTGGTGTNATATTTGATTAGACCCATCNNT TGCNGGAAACCAGNTNCACAAAANACNTCNACAANATGCATTCAGANNTCANGTGATNT CTCTCAGGGGNACTNTTGGAANACAGACCCANAGAGNGTAACCCTTTNTGNNACGGGNN GTGNAANANANAAANC^CATACTTTNTTATTTNAAAAACTAATATNNTNTTTNT^

AAACANGAANNNNCANGGGGGTGGGNGGTNCTNTGGACNCNACCGAGGAANGGNGTGC CC(^TATATATNATTTTTTATGANGGNGGTTTAGAAGGTGGAAATNTGTCNAANTGNGNG GTTCTTTTGATNANANACCTGTGNCATAANAGGGNGGGGNCTGCTNTTTTTTCCCCCACCA GTTTTNTTTTTNGGGGGNGGCTTTTTTT^^

AAAAAAAAACCCCTNTTTTACCTTTTTGAGGAAA

TTNAGCCTATNTGGAGCTNCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG CCTGNAGGAATTCGGCACGAGGCTCCCCCCTCCCCCCGAGCGCCGCTCTGGCCCGCACTG

CGCTCGCCCTGAGCTCCGGCCTCNTGTTAANCCAGCNCCGTTGNCNCNTCCTTCNAGNCNC

NNTNNTNANNNTTNNCCGGANCNTNN^ AATCCGGANGGNCNNGNCCGGCNTGNNNTNGAAGGGGNAGGGAAAAANGGNNATTAGN

NCAAAGGN αsπSTTNANNANNTNCTT^ GGCCAANNGGCNCCAAAGNCACANNATTCTGTGGTGTNATATTTGATTAGACCCATCNNT

TGCNGGAAACCAGNTNCACAAAANACNTCNACAANATGCATTCAGANNTCANGTGATNT CTCTCAGGGGNACTNTTGGAANACAGACCCANAGAGNGTAACCCTTTNTGNNACGGGNN GTGNAANANANAAANC^CATACTTTNTTATTTNAAAAACTAATATNNTNTTTNTΠ AAACANGAANNNNCANGGGGGTGGGNGGTNCTNTGGACNCNACCGAGGAANGGNGTGC CCCNTATATATNATTTTTTATGANGGNGGTTTAGAAGGTGGAAATNTGTCNAANTGNGNG

GTTCTTTTGATNANANACCTGTGNCATAANAGGGNGGGGNCTGCTNTTTTTTCCCCCACCA NCACGANTΓNTTAAAAAAGGGNCTGATGGTGTCTTCNGCCTC^^ GTTTTNTTTTTNGGGGGNGGCTTTTTTTTT^^ AAAAAAAAACCCCTNTTTTACCTTTTTGAGGAAA

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCGAGACGAGCGAGGCAGGAACGTGGACGTCGGGTCTNTCG TTTGCACCGCGAAGACACCTCTNCTGCAAAGATGGTCAACGTNCCTAAANCCCGCAGGAN TTTNTGTAANAAGNGTGGAANGCTTCANCCTCNCAAAGTGNCCCAGTTTANGANGGGCAA

ANATTCCNTGTTTNCCCAGGNAAAGAGGCGCTTTGATCGGAAGCAAAGTGGNTNCGGGGG CCAANCCAAGCCATTTTTCCGGAANAAGGCTAAANCCCCCAANAAAATCGGGCTGNAACT TGAATGCGTTGGNCCCAACTTGCAAATCCAAAAGGATGCTGGCCNTTAAAAGGGGCAAGC TTTTTGAACTTGGAGGAAATAAAAANANAAAGGGCCAAGGGATCCANTTNTAAGCTTNGG GATTCTTTTGGNCTTAAGGTTTGANAAAAAAATGTTGAAGTTNCCNAAAAATTGCCTGAAT

GANAATAAATNCCGNGATNTTCCTTCTTAAAAAAAAAAAAAAAAAAAAAACTTNGGGGG GGGGCCCGGGCCCCCAATTTCCCCTTTAGGGGGGNNNNTNAAAr^^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNTSINNTSINNlsπsπsπStNN^ GGGGTTNAAAAAGCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCGCGCCCTGAGCTGCAGACCGACCTAGAGCCCCCGCCCCTGCCCGACTGCT CACCCGCCGCCGCCATGCCCTTCTCCAATAGCCACAACACGCTGAAGCTGCGCTTCCCGGC CGAAGATGAGTTCCCCGACCTCAGCGGCCACAACAACCACATGGCCAAGGTGCTGACCCC

CGAGCTGTACGCCGAGCTGCGCGCTAAGAGCACTCCGAGCGGCTTCACGGTGGACGACGT CATCCAGACCGGCGTGGACAACCCAGGCCACCCCTATATCATGACCGTGGGCTGTGTGGC CGGCGATGAGGAGTCGTACGACGTGTTCAAAGAGCTCTTTGACCCCATCATCGAGGACCG GCACGGAGGCTATAAGCCCACCGACGAGCACAAGACCGACCTCAACCCCGACAACCTGC AGGGCGGCGACGACCTGGATCCCAACTACGTGCTGAGCTCGCGGGTGCGCACGGGCCGNA

ACATCCGCGGGNTTTTTGCCTCCCCCCGCATTGAAGCCGNGGGGAAGCGCCGGGCCATCG ANAAGCTCGCCGTCNAAGCCCTGTCGAGCCTTGGACGGNGAACCTGGGNGGGGANGTACT ATGGCGCTTCAAAAGCCTTGACGGAGGGNGGAGCAACAAGCAAGNTTATCGACNACCAC TTT(^TTTTTGAANAAANCCCGNGTCGGCCCCTTGGTGGTTGGNTTTTGGGCATTGGGCCC CGGGAANTGGGCCCGAACNCCCCGNGGGGATTTTNGGNATTNAACGAAAAAATAAAAAC

CCTTTCTTGGGGGGGGGATNNAACCAANGGANGGGACCATTTTTGGGGGGGTTATTTTTC CATTGCNAAAANGGGGGGGCNAAAATTGNAANGGNGGGNGGTTCAAACNCCTTTTTGGG AAAGGGGCCTTAACCCNAAAATGGNAAAACCCNTTTTN

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGANTNCNNCCCTNGGNGACAAACCCGATNTGGCTGANATTGAGANGNNCGATAAGTC NAAATTGAAGAANACGGANACGCAAGAGAAAAATCCACTGCCTTCGAAAGAAACGATTG ANCAGGAGAAGCAAGCAGGCGAGTCGTAATGAAGCGTGCGCCGCCAGTATGCACTGTAC ATTCCACAAGCATTGCCTTCTTATTTTACTTCTTTTAGCTGNCNAACTTTGTAAGATGCAAA

GAGGTTGGATCGAGTTTAAATGACTGTGCTACCCCTTTTCACATCAAAGANTGGAGAACT ACTGACANCGTAGGCCGCGCNTGCCTCTCCCATCTGCTTGTGTGGCTGGCAGGGAAGGAA AAGAACTTGCATGTTGGTGAAGGAGGANNCTGGNTGNTACNACAGNGAAATCTACAGTA AAAAGCTGGTCCAAGGTGTTCTGCGGNCTGTAAAATGCAGTTTAATCAGAGTGCCATTTTT TTTTGTTGTTCAAATGATTTTANTTNTTC^

GTTTTAAAACCTGAAAAAAAAAAAAAAAAAAAAATTTGGGGGGGGGGCNGGGNCCCNAT

TCCCCCTTNTAGGGGGGNNNNNNNNNANN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNτ>INr>πNINNNNN^ NNNNNNNNNNNNNNr^fNNN NNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNC

TTNNACAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGAATTCGGCACGAGGCCGAGGTCGCACGCGCGAGGCTGCTCTGCCGCCGCTGAG ATGCGTTACGTTGCCTCCTACTTGTTGGCCGCCCTCGGGGGCAACTCCTCCCCCAGCGCCA AGGACATCAAAAAGATCCTGGACAGCGTGGGCATCGAGGCAGACGACGATCGGCTCAAC AAGGTCATCAGTGAGCTCCACGGAAAGAACATCGAGGACGTCATTGCTCAGGGTATCGGC AAGCTGGCCAGTGTGCCGGCTGGTGGGGCTGTGGCCGTCTCCGCTGCCCCAGGATCGGCA

GCACCCGCTGCGGGTTCTGCTCCAGCCGCAGCAGAGGAGAAGAAGGAGGAGAAGAAGGA AGAGTCGGAGGAGTCAGATGATGACATGGGCTTCGGCTTGTTTGACTAGAGTCCCGCTCC CCTGCAAATAAAACCCTTTTΓATGTAAAAAAAAAAAAAAAAAAAAAANTNGGGGGGGGG CCCGGNNCCCAATTCNCCCTATGGGGNGTCGNTTNNCANNNNNNNNNNNNNN^ NNNNNNNNNNNNNT^WMSIN^

NNNNNNNNNNNNNNNNNNNΠSENNNNNN^

NNNNNNNNNNNNNNΪNNN^ NNNNNNNNTNNNNNNNN^

NNNNNNNNTSΓNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNTSINNR (NNNNNNNNN^

NNGGNTNANNAATCNTNCATNCANNNNNNTTTNTTNTTNCC3S[CCCCCNCCAC(^ TCCAT(-^CCCCCC(^CCCCCCCCNCAANGGGGGGTNA(^CGTATGTTCCCCCNCTTTNAGC CNCATTACGAACNNNCTCTCNCCNTCTCCATTNCTCAσsrAATACCTTGTTTNNNTCTTNCπ TTAACCNTTCO^JNCCTCATCTCTTNTTTCATNTTCATTCATCATATCANTNNNTTCNCC GAANTGTCACTCTACTCTNCNCACTTNTAAC GCTNANGCCTNANCTNAATGATACNCAANGNTTNAANNANGTCTANNCACNNTNNGGGA TANGNNNTGANAGNGNGTTACCNGNNNNGGGGANANNNNTTNGNNANCTTANTANANCT

AGTNTTACTTNCTAATCTCNNCTNNAATCMNACTTGCACGNANCCCTNGNAGCTANNNCN

GNNNNNANTGTNAGANANGTGGNNNNGNGNNCANNAGNNNNNACNNAACNATANANN ACNNNGNlSπSfGAATNNANITTGN^

NNCGCAACTANGNNAGGGNCAANNACTTACNTANCTTCCCCGTTTNANANGAAANNNTTN GNNATGCNNCGNCTATNNANNCNATNNGNGANTCANNNNNNTAANTNANNCNNGGNCNN

NNNCCANNGCTTNGTΑSRANTANATTATNCTNNNANGOSINANTGANCCGNNAACNGACGA NTTGACNGGGNGGANGANNANGGNNGGCNNNNNGGNTANATATGCANTNGCNACNNAA GCTNCGNGANTWCCANNTTNTTANANAGTNTTNGTGNANNTCANGNTNGGNNNCACTCN AANTANNACGTGTGCGNNCNTGNCTGCAAGGACNTCNTAGNATTAANGNNNGNGTGACN AACACNNTNATGTGANCANAGCTNTACNNTNAGTTTCNTNTGNANACNNTGCTNNCTGCG

ANATNGAGTNCGNCNNGT(^ATANTNGTCNNNCNC3SFATNCCTNNTNNCTGNTNC NCTCATNNNNAGTANTTNNCCTCANNCNCNTNAACNTGAAATATNCNNCNGTNGCTCCTT CANCATGTCCNTGANTGANCNCTATGNNGNCNANNCAGNNTCNNCGANNATGTNCTCNNC GANCAGCATNANTACNTTNANNAΑSFTAAGNTATATNTCACNTANNNNATCGNCAATGTGC CNTANTAGAGNNGCGTANNTNNGAGT(^TANNTNTACACATANNNTANNNNNTTGGCAN

NACACGATCCTGTTANTAGTAANNNCTTNCNNCNTNCNTGTNTATGACGTTACCCNTGNG ATCTGTAGTGNTTNNGCATCGNGTNATGTTNATGNGNNANNNTATNNCTNCNATNTTCNC ACTNTNNTACTTTNGTGACGTTNNACGCGAANNNANATTANNNTATANNGNACTNANCCN NCCGATNTNTNNTACTΪNΠSΓTGANTATCTC TGNANACATGNCTATNACNNGANTGNATTAAATNTCTNNCNNCG

TTTANCNCNNNNAGGNNNNOSFNTTTTNNANNGTATCNCACTACANAACTAGGGGGATCCC CCCGGGGCTGGAAAGGANTCCANGNGGTCATACCCANGGTTGGNAGATGAANGGTTATTC AGGNTGCCCGNNNCTTCTGTCNACGAGCCNANTCCTTGGNCAACAAAATGANNTTTNAGG

ACNTGGTTNAGGCAANCCANCANNNTCAACAAATGGCCATCCCCGNAAAGNGAAAAGGG (^ANAACTCTTTTCTGCTTAANTTAANCTTTAGNNAANCCCACATNGCTCNTNNCCCCNAN GGGGNAANCTGAACCATTTITTTNNNCCNCTNNATTTNNGGGGNACC TNTCTACCGGNNTSRAAAAATTTTTTTTTTAAANAAANCTNT^ AAAAANGCTTAGATTATAATCNTTCTNTGGCNCNNCTGNNNTNTNACGAAAAANANNCTC

TNGNTTGTTAAGAANTISINNANAA^C^^^

NGGNGGTCNCTCNNCNNNTNNNNNTGGCGGNGGGANATATANACNANCCNNNACATCGC C [NTNTCTTNNGAAATNNG]NINCNCT^ GTTNACANANCATTTTNTNNNNTTNNNANNNNACCCNCNNCACTCTNTN^ TANAGNNTGAGACTTATNTTACANTTCNNATATNTNTTNGNACATNTAAATCTTCTTACTT

CCCANTGTGCCTNNTTA(^C^CTGTGNTN^

TTTTNTTAANACTCTNGNCNANTAATCNCNAANACANTNGCCNCATNACAGCCTNCTCNA NAT(^CGNTNACATANANTGANACTTGTANTNCNCATGAANTGNANNTCNNCANTANATT CATATNNTTAANTTGAOSRCCTCTTATCTACTANCGTCNNTTNANTATANTTNNTCGANTCN NNCTNTANNTNATCTACANCGTNANNACTTTCCTANTAANNCATTNNANCNCCTAANNTC

ACGNCNANGANTAGTTNCCNCNACNNTCCC

GGTC^ANNNAGGGNNNTANNCAGNCCOTCAr^NNN^ GTGGNANTACGGTATTTAACAAACGTNATTACCANNTACANNNNNNNCGGCGNCTATNAC

CTGCNNTNCTCTCACTNTNCCACCCCCACTCCCNCCTACNTNNNTTNTNTNTCNTCNNTCN

ANNTNCCNNNNTNCANTNTTCCNN^

ANCNCTACNCCCTCTNCGNTTTTCGCATCCNNTNTC^

CCCCCCNCCCGCT(^CC(^CTCCNTTNCTNasrGTTNCCTNTTNCTCCTNNCTNTCCAC(^ CTTCCCCCTCGNCATTCTNCTCCTNCTTCCTCCTTTCTATTNTCNGNCCCCCNNNCNCCTTT

ACTNNACTATTTCNNTNATTCCACAT<^

CCCGNNNCTGCCCGC(-MSfCaWTCaSfCCTTN(^CGTNCTCCTGTANNTNTTGNCCCNCNAT

TNCCCCCTCTTTNNCCCNTCATCTCCCNN^

G(^CGCCGCCCGTTCTN(^CCNCCANNCCTNCCISINNTNTCATCTNCCCCGTaSlNNTNT^ NTCTCTNNCCNCC^T(^SINCNACCCNTCCCCTCGNTGCCCNCNCCNACCTNCGNTCTCNCCN TTACCACTNNCTC(^C<^CNNTSOT^ C<^TCTCTTNTNTCNTATCCTNCMN^

GCCACTTCCATCTNCTNCNNTC^TC WTTTCCGCGANTCTACANCTTCACTCNACACTCC C(^CNTTCNNCNNCNNTCTCGCTCCACOS[CACGCCNTGANTNTGNAαwαSfCTACCTCCN

CGCTNCACCCNTCNCNCCAG(^CNCTCNTCNCTαsrrCNCTTCATCTCNC(^CCTACNCCCC NTNCNATNTNCTCC(^CTCGNNNGCNATCTNCNANCTTTCNTCANNCTCTCTNTCCCATGC TAAAC(^CCTC^WCTCNαsrrATCNNTCCGCTTCTCCNTCCNCTCCNCTNTCCGNTCGTGNT CCCCNNNCG(^TCNCCTCCCGN(^TNCTNANCCTTCGTCNαsINGCTCANCCNCTTACTNNC TNTNNTTCATATCNTCATCTNACCGNNN^

C(^CCACCGNTATTCTC(^CCCACAGNNCNCNTACTCTCAα [NNCTTNTCTCACATCTCTC GATCNNCTNCNCCTCACCGCG(^CTGCCACGCNNTCCT(- GNCCTCTTCTTACCCGCCNTC TACANTCGACTCTTCGCCCCATCTGTCTCNCTCTACCCTCTACTCCTACNNTCNTNNCANTG TATCTNCTCA⁽^TNTNNNNNCNTNANATATNNNCTANACTTCCTNTTCCT^^ TCTANAGTCCTCTTCT(^TNGCNTCCNACNTCCCTNNNCTCTNCNTGCTCCCATCGAATNN

NCGNNNNTANCAACCCCCCGNNNTNATTCGCG

TTTGAGCCACCATNGGGAGNNGCNTTACAGTGNNGGCCGCTCTAGANCTAGNGGATCCCT CGGGCTGCAGGAAATTNCAGCACGAGGNCAATTNTGNTTCACCANCAGCTCTACTGNAGC

CNNGGCGATAAAATTCGGCCAGGGTTCTCGNTCTTGCCGNCTCTGCTCCAACCGGCACGG TCTGATCCGGAAATACGGCCTCAATATGTGCCGCCAGTGTTNTCCGCCAGTATGCAAAGG ACATCNGNCTTCNTTAAGGTACGCTGGCGNACGCCATGGNCTCCTGTTNCAGGANAGGGN CNACAANCCGGNAGNTCGGCGTCCGNGNTTGATTCAGNGCCGTTCATCTCTTTCAGCTAA GCNGGGCNTCTTNCTTTGTAAGNCGGACAACAACAGCNGANAGGCTCGNCAGNCATCTTA

ATAGGANTTGAGGGGGANNGTGAAGGCTNTGNAAAANGTAGATNTTCNTAATACCTNTTT ACCCATNTCTGNNAGNTGTAGGTAGCTATATGTAACNGTAGGATANACNTTNCTTTTNCCG AANTCCNTTNNACATGAAAACNTTAAATCNCCTAATCATATCCTTNGTNAANTTTNNCGNC AAAATAACNTGCCCTCTGAACCGGCTTGCCCTTGAACNTAACCTGAANNAATGGTCAATG TNCCTCGANCCNTCNANGGGTCTNGAGGGCCCCAGTAANACCCTTCTTAGGAANNCCNNA

ACGCCCNNNCCNTTCTAATNAT^ CTTTATNGACNTCTNNGTCNNANTCGAGTTCACAAG NNTAAANACNTTNTCCCNNGGGNANNAANNCAACTANNNTGGNTTCNCTTNCAAAACTTA NTANNGTCANNGNNTTTTTCGGNCNNNT NNTNTNTANNNCGCNCNAANTAANNTTCCTCANCNNGTGTTTNNTTCAGAANNAANANAT ATNGANGCCNCNATCAACTATGCTANTTNNNTNCTCANAANNCACCCTTCATNGTNNGAG

AC^ACTACCTNTATTNTTTNTCG

CNNGGCGATAAAATTCGGCCAGGGTTCTCGNTCTTGCCGNCTCTGCTCCAACCGGCACGG TCTGATCCGGAAATACGGCCTCAATATGTGCCGCCAGTGTTNTCCGCCAGTATGCAAAGG ACATCNGNCTTCNTTAAGGTACGCTGGCGNACGCCATGGNCTCCTGTTNCAGGANAGGGN CNACAANCCGGNAGNTCGGCGTCCGNGNTTGATTCAGNGCCGTTCATCTCTTTCAGCTAA GC^GGGσsrrCTTNCTTTGTAAGNCGGACAACAACAGCNGANAGGCTCGNCAGNCATCTTA

ATAGGANTTGAGGGGGANNGTGAAGGCTNTGNAAAANGTAGATNTTCNTAATACCTNTTT ACCCATNTCTGNNAGNTGTAGGTAGCTATATGTAA(^GTAGGATANACNTTNCTTTTNCCG AANTCαS[TTNNACATGAAAACNTTAAATCNCCTAATCATATCCTTNGTNAANTTTNNCGNC AAAATAACNTGCCCTCTGAACCGGCTTGCCCTTGAACNTAACCTGAANNAATGGTCAATG TNCCTCGANCCNTCNANGGGTCTNGAGGGCCCCAGTAANACCCTTCTTAGGAANNCCNNA

ACGCCCM^CCNTTCTAATNATNNCTTTATO^

NNTAAANACNTTNTCCOSINGGGNANNAANNCAACTANNNTGGNTTCNCTTNCAAAACTT^ NTANNGTCANNGNNTTTTTTGGNCNNNTrWAACGTTCTCCTTαsiN^ NNTNTNTANNNCGCNCNAANTAArø ATNGANGCαsrCNATCAACTATGCTANTTNNNTNCTCANAANNCACCCTTCATNGTNNGAG

AαsrACTACCTNTATTNTTTNTCG TTGANAANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGCTNTACCANCGAGGCAGGAACGTGGACGTCCGNGGG GTACTCGTTTGCACCGACGAAGACACCTCTACTGCAANGATGGTNAACGTNCCTAAAACC CGCAGGANTTTCTGTAAGAAGTGTGNAAAGCATCNACCTCACAAAGTGACCCACTATAAN AAGGGCAAATATTNCCTGNNTGCCCANGGAAAGAGNGCNCTATNATCNNAANCNAAGTG

GCTACTCTGGNCNAN(-MSfAGCCAATATTCTNNANTAAGNNTNATANACCNCCACCAATNA NCGNGCTTAGACTTGANTGCTTTTGANCCCATNCTNNt^TNTCCαSTNCNGGATNCTTNTCC CATCACTAGNNTCCCNGCATNTTTGNAACTTNTANNNANTANTAAGANANANNNNNCNGG CCNNATNTGATCACAGNTTNTCNNTGCTTGNCGGAANTNANTTNTNANNNCTTANTNNTT CNAANAAAGAAAATTNCTTGAAATTTNANNTCATACATCTGCNCTNNAATNANNAN^

GANANNNNCCCATANTTTTTTTGTNTCGCAN^ GNGNTTTCCTTCNNTTCCCNNGTTCTTNNNNTTNNTATNNTTA ANTOSINTNTTGNNTNNTT CNTTGCNCCαSfTNNNTTNTCTN^ TTNNCNCATG1TCCACTANTTCCTCTTTNTGTTNNTATATTGNTCCTANCNATCCTNTNTTT NNTCCCTCTTNTTAN(^AGNGTGNTTA<^TNTNTTNNCCNTTTANNNCNTGNT^

NATGNlNnSTT^TC TNI CTC^^

ATCNTTATNTTTGNNATCTNNTACACNTNTGAACANCCNTNTCACCATTGTNNATCNCTCC TTNTCATCTNCTNTNCATNTNNI INTNACCATCNNNTTNATCCTTCNNTCN

GNGGTTNAANAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCC CGGGCTGCAGGAATTCGATATCAAGCTTATCGATACCGTCGACCTCGAGGGGGGGCCCGG TACCCAATTCGCCCTATAGTGAGTCGTATTACAANCCTGAANAGNCTTNAACCTNCTANNT GNCGCTGAANAAAGNCANGACGTCAANNNNGATCANGAGACAACCAATTATACTACCGT ACAATGTAANANNCNCANTCNATTCCCTATANTGAGTCTTCATAACAAATACCAATCATA

ATTGGAGGATTCGGTAACTGACTTGTTCCCCTAATAATTGGTGCTCCCGATATAGCATTTC CCCGAATAAATAATATAAGCTTCTGACTCCTCCCTCCCTCATTCCTACTACTCCTCGCATCC TCTATAGTTGAAGCTGGGGCAGGAACAGGCTGAACCGTGTACCCTCCCTTAGCAGGCAAC CTAGCCCATGCAGGAGCTTCAGTAGATCTAACCATTTTCTCTTTACACTTAGCAGGAGTTT CCTCAATTTTAGGAGCCATCAACTTCATTACAACAATTATCAACATAAAGCCCCCCGCAAT

GTCACAATACCAAACCCCTCTGTTCGTATGATCCGTAATAATTACCGGCCGTACTACTACT ACTCTCGCTTCCTGTATTANCAAGCCGGCATCACAATGCTATTAACAGACCGGAACCTAAA TACAACCTTNTTNGACCCCGGCAGGANGANGANACCCTATTCTATATCAACACTTAATTTT GGATTCTTTGGGACCCCCCCGAAATCTTATATTTTNAATCTTAACCTGGGGTTTGGGAAAN AATCTTCTTATTATCGGGGAACCTACTTACTTCANGGAAAAAAAAAGAACCCNTTCNGGA

TATATTGGGGAANAGGTTTGGGGCTTTTAAANGGGCAAATCGGGAANTTTTAAGGGTTTC AATNN

TTGAAAANCATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGANTNCANCCNTNGGNTTTNTNNCCGATNTGGCTGNCATNGNGANGCCCGGG GNAGNTTCNAATATGAAGANNNCGGNTACNCAANATATNAATCCACTGCCTTCNAATGAA ACGATNTGAACANGAGAAGCAAAGCANTGCNATTCNTAATGAANCCGTGCGCNCGNCCG T(^GCACTGTNCCATNTCCANNAAAGCATNTGCCNTTNTTATTTTTAACTNCTTTTNACN^ TGTCTAACCTTNGTTAANTANNCTNAAGGAGGGTTGGATNTGAGCTTNAAATTGACNTGT

GCTACNCCCTTTCCACATCANAANGANNTGGAGAACTACTGNCAACGTAGGCCGCGCCTG CCTCTCCCATCTGNNTAGTGTGGCTGNCACGGGAAAGGAAANNAANTTGCATTGTNTGGT GANAGGACNGANTNCTGTTTGNTTACCACNGTGAAANCTACAGNTAANAAAGCTGGNCC AANGGNCGNTNCTNCTNTNCCTGGAAAAAATGCACTTTTNAATCAAAAGGTGCCTTTTNTT TTNTTNTTCNTTNC^AANNATTTTTAATTNAπ

TGCANAAANAAAANTNCTNAAAANCCNTGNNNCCCANNGNNAAAANAAAAACATNNNG NGGGGGGNNNNGGGTTCCCCCATTCCCACCTTNTNTNNGNCT(^TTNNNANAAATATAAC CAGCCCCCGTANCCTNINCTrxINTNTNCN^ NTCCNTTNTNTNCCHNTCTNTTTTTNNTTTCCO^ WaS(TCGC(^TNANACTTACNNNCTAATNCTTCaS[NNCCCAAANCTCCCANCTNNCN

TCTTANGCANTNANNTCCTNATCCAANCAAGACNTATTACACCNTTCTNTTACTNNTTTNT TACTNTCTCANCCTN(^TTATCTTACACACTCGNNTCT(^ATTNNCANAGTCNANCNTNAC CN NACAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCTGACAATGACATCGGAGCTGTCTCAACGACAGGGCACGGT GAGAGCATCCTGAAGGTGAATCTGGCCAGACTCGCGCTCTTCCACGTTGAACAGGGAAAA TCACTAGAAGAAGCTGCCAACGCATCACTGGGTCATATGAAGTCAAAGGTCAAGGGCGTA

GGTGGTATCATCATGGTCAACAAAGCAGGAGAGTGGGCGGTGAAGTGGACCTCCACATCC ATGCCCTGGGCAGCGGCAAAGGATGGCAAGCTGCACTCGGGAATTGACTTCGGCGACACG AGCATCATTGACCTGTCCTAAACCCCCAGAAGCTGTATTCTAGAAACTAGCTTGGAGGTG ACGCACGGTCTCCTGGCGTGNAGACTTANCTTCATCAATTAGATCTAGAACTAGAAAAAT TCTGCAGCCTGTCACTCGTTTTGTTGCCTNGATCAGTGTCTGGTTGGGGGCGGGTTCCAAA

GTGTGTGAGANACGCCCATGTTAAGATAAAAATAAGACCAGTGAAGATGACCAACTTCAC GGAGCCTNCCTTATGAAATAAGTCCCCATTGTCTTGAGATTAGAAAGAAGAAACCNGCAA GATCTTAACAGTAAAGAAAGGGCCTCGATGCAGGGAACGGGTTTGGAAGTTGGGGGACCT ACAGCANTAACAGAAGCTGTANGTTCAAGGGTGTGGGGGGTTCGGANGAAAAGGCTNTG GGGCCAGGACCCATGCAGGGCCAACAGGCNGGAAGGANCCNNNGGGACCCCGGGNAAG

GGACCCGGGNNCCAAANTTATGGNACCCTGGATTGTTGCAAACTTANTTTAAAAGNCGGA A

NGCNNCGGCGNCGCTGCGNTCNTNNNNNNNNNN

CACTTTTNCCCTCNNTCCTCCNTCACCCNCCCTNCCCNANGGGNGGNNAGTNNGTNNGGN ATCTTTCCCTTTNAGNCCCCATAGGAGCCGCATNACANGGCCCCCGCTCCNGCATCTAGTT GGNTNCCCCCGNCCTGCCANGCANTCTNCATAANTATGCATTTTTTTCTCTTCTCCTCCGG NGGNCN( NCNTSENTATNTCANGNCCT<^T^^ NNGNNGNAAACCNTTANTCNNGATTTNNTATGNNNNNATNACNTNTNCANGANNNCTN

ANNNTATNCTNGCNTNGNANANAATCCANNTTAAAGGCCNAGNN^mANGAATTTNAATN NNOSrGCCAATCANNTNNNTNANNATTANNNNNTAAAANCCCNAAANCTGGCATCNTCNN ^fNACTACNTATTCCCTTNTATNANNGNCANGNTAAANNNNNNATCTATNAANGNCCGCAN GOSπSfNCCCANATNCNTTATACGNGTNCNNAAAATNNNNCGGGNCGATNCNACNTCNCTC NCNCANANTNTACCTCNGCTNNNANTTNTO^

TNANNNTNATTGANNNTNNNGNNGGANAGGNGNCNNNATANNNNTNCNTTTNCGACNNC CNGCNCNNNGAANTCAGCCATTCTNAATTOS1NCGNNCGTTTANTAGNNTCGANTTCNANT NNAACTACGGTCCCTAAACTCCCCNTNNNTANNNNGTCANTNΗNTATCGTTATTNATCGC GACNCCGANNATTTNTTTGTACTTCGNCANNCTANTCNANGGA(^ACANTAAATTTANαS[ CNACNNTCNGATANNTTTANNTNGNTGNNACNCANCNCTATNNNNTATNCGTTACTTTAC

CTCTNCNGTCGGAGCGNCANGCCTANNTCNTTCCTANTCNTAANCCTNTTCGCNNNNCNT ^• GACNCNAA(_MSfCNTGANATNNTTTATNCATAANTTANGTNNGCTATACNAACGNNNANT^ NCTNNNCACGCNGAAANNNCNTNt^CTCTNTCCTNTNACTNANOvINNTCCNGAACCAN^ TGTNNGTNANANTGTNCATNTTNT(^GTNANNC^ CTGTGGATGCTCCNATNTGNNAACAATACGNACNNCCNCNTGGANTCNNCNANTGNNCGN

ACTNTANACNGCNACNCTATAATNNACGNCGNTNNCTTCATACNCNACNCACNTATNATA NCGTATCANNCTNCANGCCAGANNCNCGNCATAGNGTNTNNGATCACACCTGCNNTTNGN CATANCGCATNTACNTGTNCATCCNACC^CCATATNGTNTTTATTATTCGCNNTGTGGATN CACACGAANANANCTCGNNACTCTCATNANNCTNAGTNTCATTNTCTNTATCTATNATGN CNGNACANNTACGTCGATATACGNNTGCTαs NTTATCTTGTNTTCGACATNATGTNGNAAT

GCTAGTGGNCACTNNTTNANNTGTGNTCTTTNATACTACGGAGCANNANACACACACTCN ATANAGTANTGATATCACTAGNTCCC

TTTTGAAGGNCCαSfTANTNNGTGGANGTTCGGTCATTTAACAAGGTGTTNTTTCCCANANN

ANTACACNCNAGCNGNTANN WT WTANGAGCATTCTNATTNCTCACTNTANGTNNTTAA TCATNACGTAGNTNTCTCCGAGANCCTGCNANAATCATNAGCNNNACNNTANTNNTANAC GGGGCNNTNACNTGNCTANTAGTGNNCANNNCAGNANAGNATNANAGGCGACNCNTNGA NAGGACGTTTNATGNGACAANAGGANTTGAGAAGCTNCGAATGNGNATCGCAANNGNGG ANNNATGACACTOWANGACGAC TATGAGANN^

ANNTANGTAGTCTTNGNTGTTNTNGNTGANCπSfNANGCTNTNGGAGAGTNNANNNGNAGN TGNCGTCTTGTNNNNTGNGGANNGGANTGNNGAGTAGNNATATNNAGTTCGTCGGTTTCN NGTGNCTACGAGACNANNNCGANTNCATNNGNNATNTNGTGAGNNTNANCTNGTCGAAG TTNCNTCNNAACGNNTATNNATNCTCNTAAGACANTACANGATNNNGATNGTCGATGANA T INNTATTANTNNCGCAGCNAGGNGACTCGNGTNGTCGTNNTGCANTOSINNGNNTGNσW

NNATNANGAGTANTGANNANNNNNTNCGAGTNNACGACACTAACNNNTTGAATANNCTN NANTANTNNNAGCGATGNTNNAACNTTTAATNGT(^GCANATNTNTNNTNAGCANNACN GNNACNAANNGATGACGCATGNNNTGTCNNCNNNTAAGTNNTNNTGTNNGNNNNNCGTC AONINTGGANTNTTNNNNTTNNNTG^

AGAAGANCTCAACNANCNCTTA<^ATNNTCTTAC^^

NNAANCGNGANNATACTGTNNNAANTNCGCANCTGN(-^ATGTANCNNTANNNNACGANT TNNANATNNTNCAANNNTACGNANT<^ANTNNTTNNGNNTACNTNTCGTNCT^ NCNATNANTGANNACGGAANNTCNGTNTATNGGCGNNTGCTNGACTTNAACNACCNNNN NGNGAATTNGACTACNNTGGANGAGNTNNGGAAGGNACTANCNCAATTGCATANNTNTA

TNAGAGNαSfTTGNTTNNNTNTNCGTAANTGTATNACGANACCTAAGGGGTCGNTGACGNG TACα^GTGNGTNNNCGACAGNANGTGNCNGACGNNNTANGGACGCNTCGANATAGTANN TNTNNATTCCNANNNTAGACKNCNNNTAGGTNATANGNACNGNNGGANNACNGTANGAT NNN(^AACGNANCAA(^TTNTGTAGTNTNCTTNNCTNNANGGANCGANNAAANTSfN^ NCTNNNAACNGAAGCAANATCNAAANTGAGCGACNTATGTACGNNACGNATGCACNNAC

GGAATGCNAACGNTCNAACGGAAAGNTTNNNNNGNNACGTATTTAANGTNNGTNNCGGN AGNGAANNGTANGTAGNGNACGNNNTCGAACGGATGCNAGTAATACGNANNTNTGNGAC GTNAATTACGCNACGN

GNCCTANTAGTGGAGTNGTATTNCATCGTATTACACTCTANAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGTCACGAGGACCANTGACAAAGATAGGANTACANNGTGTATTAGGNN ANCCNTCATTCTTGCACTAAGCACCAGAAGACTNGANAAATCTAAAAAACAAAAAAAAN . ANCTCATTNAACTAGGATAATTCAAANGGAATATTAAATCGATAAAACCAGGACTCACNT GCCAAAGTN(^CATCANGGGACGCTCACATNTNGTTTCCTTCCATATAAAACTTGTNNGCC

GCTATATTNAAAGCCTTTTTTCCAAATATTTTCATTGANTTTCTGCNAGATCTANAGCTCTG CTCAGTGCCTCTACAAAACAGNGTACAATTNTTATACTGCNTNGANAATCCCCCCGGTAA NAANCATGTGCANCTNTGCAANANTTTTTGCTCAAAAACATNANTGACCTGAGAGCAACT NNCCTTTCTATTCCTAATTGCTACCTACAGGACCAGCAGGGAGAANTNTCCCCTNTTCCCC - NNCANAGAATACTGTNATGCAATTTACNNNNNGGATGCNTNAGGCCTTGNTGAAAATTGA

NGCCTCACCCTGAAATCNATAAGCCCTCCCCAGGGGAAGNNAATTCTCTNCNGCTTCTGT NCTAAANTNGTNC(^CNTNCCCTAGTNNGTACANTCCACTTTTNCGGGCAATTTTTNATTA AANCAAAAATNCTTGGTGTNCTTTTTCNTAGAACAANCTATTATATTCATTTΠ TTTNCTANTNAAAANCCCANNNGGTNTACCTTNNNTAACCCTCTAAAAAATCTGNCACTTT TCCNGGGCNAANAAAGGNTNACTACTTTTTCTAAGGNGATAATNCAANATTCCNTTTNTCT

ACTNGTGTGGGNNTTAANCNTCTCTTTTAGGCAANGNGNGTCGTNATAAAAAACNGNCTN CTCTCCCCAANNGTNNNTTGNCNOSΓTGNNTNANNNTTTTTCGATATTNAANA^ CCCCNGACCCCNGCG

TTGAGNCCTNNTAGTGNNGTNGTATTACANGTGNNGGACNNTNTAGAACTAGTGGATCCC CCGGGCTGCAGGAAATTNCGGCACGAGGGCNANNTGGGTCACCAGCAGCTCTACTGGAN CCNTGCTNTAAAATTCGGCCAGGGTTCTTNCTCTTGCCGGNTCTGCTCCAACCGNCACGGT CTGATCCTNAAATA(^GNCTCAATATGTGC(^CCAGTGNTTTTCCANCTGCATAAGGACAT CGGCTTNNTTAATGCACAGCTGNCGGACNCCANGGTCTCCTGTTTCAGGGAGGNGCGACA

AGCCGGTANGNTNGNCGTCGGCNNTTGATCATTTGCNCGGTCTTCTCTNTCCCTAGCAGGG CTNTNCCTTTGTNTCGGGACAACACANTTNANAGGCACCGNGNTTCNTTTNAANANGANT GAGGAGNGANGNGANNGCCNNNCANCANNTAGTATNNNNTAANACCNTTTTACCCATTN 1WTG(^AGTTTNTAGGTGCTATATNTCTATGNGANNAANAAAACNTTACTTTTTCACAANT CNCTAATAATGANNCCNTTNANTNCCCTTAANCATTATNTTGGGATAΛTTTTTTCNCCNΠ

AANANCATGCCTTTGAANCGTTTTTCCCTNNTTATTCACCCGANCTANGGATCATGTNCCN (_^CCCTTGAGNGGTNTNNNCTCNTGNANTNNACCCNTTTTTAAGACNTCANAAG CNTCAATNNGACTATGGCCTTCHNNAACTTTCGGCCCTAAGGTC(_NTTAAANGNTNANNC TTTTNCCCNCGATNNAANAANT^^ GTNAAACOSINTNTTCCTTTACNTCCTC

NTTTTTNNCΓIWAAAAAANTAANNAAC^CCTN^

NCCCTGCCCCNCCTCTCTTNTNTTTATTNNCCAAGTNNTNNACGCNTCTCNNΠ

ATATTAAAACNCTTGTTNTNTNCG TTGAGNCCTNNTAGTGNNGTNGTATTACANGTGNNGGACNNTNTAGAACTAGTGGATCCC CCGGGCTGCAGGAAATTNCGGCACGAGGGCNANNTGGGTCACCAGCAGCTCTACTGGAN Cα^TGCTNTAAAATTCGGCCAGGGTTCTTNCTCTTGCCGGNTCTGCTCCAACCGNCACGGT CTGATCCTNAAATACNGNCTCAATATGTGCCNCCAGTGNTTTTCCANCTGCATAAGGACAT

CGGCTTNNTTAATGCACAGCTGNCGGACNCCANGGTCTCCTGTTTCAGGGAGGNGCGACA AGCCGGTANGNTNGNCGTCGGCNNTTGATCATTTGCNCGGTCTTCTCTNTCCCTAGCAGGG CTNTNCCTTTGTNTCGGGACAACACANTTNANAGGCACCGNGNTTCNTTTNAANANGANT GAGGAGNGANGNGANNGCCNNNCANCANNTAGTATNNNNTAANACCNTTTTACCCATTN TNTGCNAGTTTNTAGGTGCTATATNTCTATGNGANNAANAAAA(^TTACTTTTTCACAANT

(.NCTAATAATGANNCCNTTNANTNCCCTTAANCATTATNTTGGGATAATTTTTTC^ AANANCATGCCTTTGAANCGTTTTTCCCTNNTTATTCACCCGANCTANGGATCATGTNCCN OSfCCCTTGAGNGGTNTNNNCT(^TGNANTNNACCαSfTTTTTAAGAαSfTCANA^ CNTCAATNNGACTATGGCCTTCNNNAACTTTCGGCCCTAAGGTC(^TTAAANGNTNANNC TTTTNCCCNCGATNNAANAANTGANNTNCCTANGGNNTCNATTGAANANAANNNCCTπ

GTNAAACCNNTNTTCCTTTACNTCCTCAA^

NTTTTTNNCTTNNAAAAAANTAANNAACNNCCTNGGCCCCNTCTGTAAGG NCCCTGCCCCNCCTCTCTTNTNTTTATTN^ ATATTAAAACNCTTGTTNTNTNCG

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTTCCTGTTAACTCTTAATAAACTTACACATGCAAGCATCTACACCCCAGTGAGAATG CCCTCTAGGTTATTAAAACTAAGAGGAGCTGGCATCAAGCACACACCCTGTAGCTCACGA CGCCTTGCTTAACCACACCCCCACGGGAAACAGCAGTGACAAAAATTAAGCCATAAACGA

AGGTTGGACTAAGTTATATTAATTNGGGTGGGTAAATCTTCGTGCCCGNCCCCCGGGGGC CNTCCAATAANCCCANNTNACANGNNNTCCGGGTTAAACGNGGTAAAGNNCCNTACCNA ATANGGGTNAATTCTTACTNANCTGGNAAAAGNCNTGNNTTAAATNAAAATNAATGNCGA AAGGGNCCCTNCCAT-NΠWCGNCNCNCTNTNNNTNANANCCNAACTGGGANTANANNCCC CANTTTGNTTANNCCTTAACCCCGNTTATTNCCTTAACCAAATTATTCNGCNGANNNCTNC

TNNCCACNGNTmAAACTNAAAGGACNTGGNGGNGNNTTATTTTCNTNTAGANGNANCNG GTNTNATATNGATAAANCCCGNTAAACCTTANCCAATTNTTGGTTATACCGTNTATTTACC GGCATTTTNAAOSIAANCCTTAAAAAAAAAAAAAAAAACTTNGGGGGGGGGCCCGGGNCC CAATTTCNCCCTTTAGNGGNGGNNNTTTNANNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNTSINN^ NNNNNNTSINNNNNNNNNNNNNNNTSπSIN^

ANCAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGNNANCAAGCTNNNCCCTACCNNCNACCTCGNAGNGGGNCCCGGCCCCCTA GGANTCCCTATGNCGAGTGGNTATTACAATCAGGTACAACTGCAAGANANNACNTTGGNN NNNANCCAAGCTGGNTCTATANCAAGCAANCTGNNTCTATGATANNGGNTCTTAACATGA TGACCCTNTTNTAGAGCANCCAGATCACAATGAAAACATCNCTNCTGTANNGNTCTGGCC CATGATGNTATNTCCTCANTATCNNTCTGACTCCCAGCAATNAATATACAGCGTNGCANA

AAAAACAAATNCCACTTGTGGGGGGGCCTGGNGACCGAAGTAANCCTTAGATGNTGTNA AGAAACAGCCTTGCATACGNGCCTGGAATGTTANCTNCCTGAATCAAGGTNANTTGAAAA TGNTCAAATNCGACATGCTCGAGNGAACATA(^CATTTTACGAACTCNGGGGACCTNAAA TGNACTGGGAATGGGTGA^CTTAACTTCANATAACCATTATTTCTACTTCNGGGGGNNGG GAATTCTTTATAANAAANGGANTTNCNTTATGGCCACCAAAAAATTTTGAAATGCANCTN

TTGGGTGCATNCTTAAAAACGGCGGGAAAGATI^CTGGTCATTTCCANGGCCNTTCCNTTC ANTATNACANAANTTCCAAGGCTTTNCCCCCCCCCAANTNTTCTTTGTTTAANCTCCGNNT

TGAACAATTTTΓGGGAAAAACCTAAANAAACCCTTGGGGAACTTAACAATCCCCNNAAGG AATNTCCTTTTTTCCOSINACCNAGGGANN^ CGGGGNTTNTTTTTTTTGGTTTTAACCCCCC^^

AAAAACCCN TTTTGAANCACCATTCTGGAAGCTCCACTCGCGAGTGGCGGCTCGNTCTAGCAACTAGNG GANCCACTCGGNCTGAANNAAATT(_^AANCCCNANGATTTTNTNTCCCNCCCANTTACAN αsiNCAGCANcαsπsπsrcTNCA^

NCCCCM^TCACATCNTΑSINNCNATCTNNTTCCMSENCCTTCCANAN NACTAAANATCCNCCTANNANCANNTATNTAΑSFTNNNNATAATNCOSINNT^

CTCACAATAATNCGAANATTATAATCATNANNCNCCNAANC1S1NCNACANANCNATNTNN NNOSRAATTCGAAANNTTCNNTNCNAANAGCNTAAACNATNANANNCATNNNNNNC^ N(^ANANNTAA(^AOS[NATNCAANT<^CCCCACΣSINCNANANAATNCACCCACNCACCC TAAANNTA(^ATNNATNC INCAΑWTAANANNATTCCTTCTCACTANCAATTNATNATAT CTATNGNNNNNCGCTNCTANNTN^

GCNTNCCCANTTCGNOS[TNAATNNTNCATTACNACCANNCGNNCCTNNCCNTCATATCTN

NNTNCNCNATNCCNCMNNATNCATACAN^

(-^CTNNANNCNCAATCACCTANCANANTTNNCCNCCT(^CNCTTNACTANACNGCCNNTC

AANNCNCATCTNATCNANNANCCCCTAACTANNTNCTTCCNNNTNCANCTCNACCCNAGN ACCTATTAACAACNNNNAAANTNTNAATTACNTNTANNACNAANATCTACAACATATCAG

ATOSINCTTTCNNTNACCACCTACCATANCTANTCNATCATCTTCCANACAATCCTNNCCTC ACCTNNNTCCNACCNNTCACOSINNCNCCACCAATCANCNATCACNNNNACCTNCACNANT ATCTTCACTANNCAANCANNTCAANTTCTCTCTATTAACANCAATCCNNCTNCTTCCNCAN CAAANATCANANNCACACNCANCNCNTTTNCANCTCNTNNNAACNGCCTAGCCCNCAATN NNNTCANCNTCCACAACANTNACTCACACATACNCNATACTNAAACNNNTNAGACNCACT

TNTTNCNCANACCATTNCAGTCCTACNCNNTNTNATATATCTNTGTNACNTANACNCAACN TCTACNANATACANTANACCGNTANTCACACNACNGNNACACNNACACACACTCGTNNTA NTACAANCGNCACCTCNTCTNNGNGNNNCANTCGTCNCTACANTCGCC

TTNNACAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGTTCCTGTTAACTCTTAATAAACTTACACATGCAAGCATCTACACCCCAGTGAG AATGCCCTCTAGGTTATTAAAACTAAGAGGAGCTGGCATCAAGCACACACCCTGTAGCTC ACGACGCCTTGCTTAACCACACCCCCACGGGAAACAGCAGTGACAAAAATTAAGCCATAA

ACGAAAGTTTGACTAAGTTATATTAATTAGGGTTGGTAAATCTCGTGCCAGCCACCGCGGT CATACGATTAACCCAAGCTAACAGGAGTACGGCGTAAAACGTGTTAAAGCACCATACCAA ATAGGGTTAAATTCTAACTAAGCTGTAAAAAGCCATGATTAAANTAAAAATAAATGACGA NAGTGACCCTACAATAGCCGACGCACTATAGCTAAGACCCAAACTGGGATTAGATACCCC ACTATGCTTAGCCCTAAACACAGATAATTACATAAACAAAATTATTCGCCAGAGTACTACT

AGCAACAGCTTAAAACTCAAAGGACTTGGCGGTGCTTTATATCCTTCTAGAGGAGCCTGTT CTATAATCGATAAACCCCGATAAACCTCACCAATTCTTGCTAATACAGTCTATATACCGGC ATCTTCAGCAAACCCTTAAAAAAAAAAAAAAAAAAACTTGGGGGGGGGGCCCGGGANCC CAATTCGCCCTTTAAGGGGGGNNNNNTAAAANNNNNN^ NNNNNNNNTSπSENNNNNNNNNNNNNNW NNNNNNTSINNNNNNNNNNNNNNNNNNNN^

GCCTATNNGGAGNNGNATNACAAGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAGAACCTGAGCAAAGAGGAGCTGATAGCCGAGCTGCAGGACTGTGAAGGCCTTAT TGTCCGCTCGGCCACCAAGGTGACCTCTGACATCATCAACGCGGCAGAGAAGCTGCAGGT GGTGGGCAGGGCTGGCACAGGCGTGGACAACGTGGATCTGGAGGCCGCAACCAGAAAGG GCATCCTGGTCATGAATACCCCCAATGGGAACAGCCTCAGTGCTGCAGAGCTCACCTGTG GAATGATCATGTGTCTCGCCAGGCAGATTCCTCAGGCGGCGGCATCTATGAAGGATGGCA

AGTGGGAGCGGAAGAAGTTCATGGGAACCGAGCTGAATGGAAAGGTCCTAGGAATTCTTGGCTTGGGCAGAATCGGGAGAGAAGTGGCCACCCGGATGCAGTCCTTTGGGATGAAGACC

ATAGGCTACGACCCCATCATCTCGCCAGAGGTCTCGGCCTCCTTCGGTGTGCAGCAGCTTG

CCCCTGGAGCAGATCTGGCCTCTCTGTGACTTTATCACTGGTGCACACACCTTCTCCTGCC CTTCACCACAGGCCTGCTGAACGACAGCACCTTTGCCCAGTGCCAAGAAGGGGGTGTGCG

TGGTGAACTGTCTCGAGGAGGGATCGTGGACCGAAAGGTGCCCTGCTCCGGGCCCCTGCA NTCCGGGTCAGTGTNCTTGGCGCTGCNCTTGGACGTTTTTCACCGGAGGAACCACCCCGGG ACCGGGCCTTNGTGAACCATTGAGAATGTNATCAACTTGCCCCCACCTGGGCGNCCAGCC ACCAAAGGAAGNTTAAAATCCCTTGGGGGGGAAGGAAAACGCCCTTCCATTTTTTGGACA TGGGGAAAGGGGAAGGCCCTTGGCCGGGGGGTTTTAANNGCCAAGCCCTTN(^GAATTTT TTTTCACANCCCCAACCTTGGGNCAATCTGGGTTAAANCTTTTNG

GGCCTATAGNGAGTCGNATTACNGGGGCGGCCGCTCTATAACTAGTGGGATCCCCTGGGC

TGCAGGANNNAAAGATGCNCATTTACCAGACGGCCCNTGCACTAANAGACCNTGNTGGG NGGNCTTGNTCTCCGCTGGGAANCACTNTNTGTAGAAANNCNNGNCNGAAACTANTATCT AGCCTGGANCACCTNCCTTTTNCCANGAGGGGATTTCATTNNTGTGGATTACTCTGGTTGT

CCTNAAAANCANATGCCMNNNCATCNANGAACANANNAGNGAGANNTNNNGACTNAGNT NTTTNACCCAGANCNACCNCGCTNTNGGATTC(^CAGATTTGNATGCNNGNGCAGCCNTC

ANTNGCAAAATCNTNANGAGAGCTTNTGGCCGGNGAAANANNATNTAANATNANNGAAT TTATCCCNGNTCNCGANTCNAAGNTTTGANNNNTNΓΓGTGNNTGATAGTNGNGTGTTNCT NTNNANNNNCTNCNTTTTACTCNTTTCCTNNNCGATNNNNCGGGO^^ NNNGCCTNGGCTNTATAGCGTNTANTNNCNCTNTTNTCTNNNTNACANRWTNCGA NNATNANNNGCTCCGCTCTCANTGCNGGATTNATAANNNNTNTGNNCNNCNTNTTATANA

TCTTCNCNCTCANTNTTNNNCCTTTT^^ ANTNTNCNNCCCNTTTTTCC^CNTNATNNNNTATTTCNNCNANN(^ NCNTCANTCTNCTGACTOSRCTANTCTTNATTANTANNNANTAGTTACATNCNNNNNGTNAT TNTCTANANTTNTANCTTGTCACGNIT^^ NCAGTGANNNTANGTTCCT<^ACGATC ΓNCTCTCGACNTGGTANTAGGTNNCTCGTATA

ANNCNCGGNTTGNC<^CTNTATTTNNTNNATATCNTTCCTTGACGTCNCNTIS NGANCNNN GCTNGAAGGTCNTNGANNAANTNTCCNATNACTAGCNANGTCTCCGATGATGACCNGCTN TCTTNNAGCNCNACTNCCGNGNACCT

GCCCTATANGGAGNTGNATNACANGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGGCAGGGCTGAGGCAACGGTGCCCACCCTCCGGCTCTCTCTCTGCTTTTCTGCGCC TCCGCTCCGCTCTCCGCCCGCCGCCATGACGGAACAGGCCATCTCCTTCGCCAAGGATTTC CTGGCCGGGGGCATCGCCGCCGCCATCTCCAAGACTGCCGTTGCCCCGATCGAGCGCGTC AAGCTCCTGCTGCAGGTGCAGCACGCAAGCAAGCAGATCGCGGCCGACAAGCAGTACAA

GGGCATCGTGGACTGCATCGTGCGTATCCCCAAGGAGCAGGGCGTGCTGTCCTTCTGGCG GGGCAACCTGGCCAACGTCATCCGCTATTTNCCCACGCAAGCGCTCAACTTCGCTTTCAAA GACAAGTACAAGCAGATCTTCCTGGGGGGCGTGGACAAGCGCACGCAGTTTCTGGAGGTA CTTTGCGGGCAACCTGGCCTCCGGCGGGGCAGGNCGGGGCCACTTCCCTGTGCTTNGTCTA CCCGCCTGGATTTTCGCCCGAACCCGCCTNGCGGCCCGACATTGGGCAATTCGGGGCAGT

GAGCGCGAGTTNANNGGGCCNGNGAGATTGNCCTGGTGAAGAATCACCCAATTCCNACG GCATTTCNGCNGGCTGNACCAAGGGCCTTCAACNGGNTCNGTGNCAGGGCCATCAATCAT CTTNCCNNNGCCGGCCTTACTTTCNNGNATNTACTAAAACCTCNCAAGGGTATGTCTC3SINC CNAANCCCCAANGAACAACGCANNATCNTGGGTNGANNCATTNGTATGAATCNCNNCNT ANANCCGGTGA(^GAGTCNGANTGNTGGGTCTTGGTNTTTTCTACCCCNTTTTTANNANCC

GGNTTCTGCTNGGGNNCATTTAATAANTTCATNNTTCNGNGGGCNCAANGGGAANCCNNN ANTNTCTTTCTCCNTAGGGNCGCCC

TTNNAGCCTATANGGAGNNGNATNACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAAATTCGGCACGAGGGCAACATGGGTCACCAGCAGCTCTACTGGAGCCATC CGAAAAAATTCGGCCAGGGTTCTCGTTNTTGCCGGGCCTGNTCCANCCGGCNCGGCCNGA NCCGNAANNNCGGCCTNANNANGNNCCGC(-^GGGTTNCCNCCAGNNTSINCAAAGNNNNTN GNTTNATTNAAGGACC(_^WGNNGNCCCCNNNGGNNTΑWGTTNAAGGNNGGGCCAACAN C(^GNANTTNNGGGGCNGGGNTTGNANAATGGCNGTTTTNTTTTTTAACTATA<^

TTΓTCTTTGGTACNGACACACACACANTGAGAGAGGNTNGCNCNTCATATNTATAATAGA TATGAGAGGGGGATATGANAAGCGCTGTGAAAAAATATATTITTTCTATAACCTCTTTACA CANATCTTGTGANATTTATAGGASNSTTATNTNANGTGNGGNNANACANAANNNTTNACAAA NNTCTNTAATGAGACANNTTATCACTCTACATATNTCGTGAAANTTCNGNAAAAAAAANN CGNNNNCNNCTGTCCTNNNAAACANAATATGGGCATNTGTAGAGNTCTNGNTGTTTGGNC

NCANATACCCTTTTAGNAAGAANCAAGACTGTGTTTATAATACTATAACTNTTGTGGACA ANCTCANANAAAATAATTTTTCTTGCTGAAAAAANAATAATAAGGGTGGTGGAAAAAANT ATTATGTTGACGGGTTNTTGGGTTGCTTNCAAAAAACNTNAAAAGGGTGGTGGGTGTTTTT TTTANNAGGAAGAAAAAATTTNTTACTGGCTGCTTTTTNAAAAAAAAAAAACTGGC^ CCTTTTTTTTTTNATNAATNAANAAANNCCNCOSfNNG

NAN

TTNNAGCCTATANGGAGNNGNATNACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAAATTCGGCACGAGGGCAACATGGGTCACCAGCAGCTCTACTGGAGCCATC CGAAAAAATTCGGCCAGGGTTCTCGTTNTTGCCGGGCCTGNTCCANCCGGCNCGGCCNGA NCCGNAANNNCGGCCTNANNANGNNCCGCC^GGGTTNC(^CCAGNNNNCAAAGNNNNTN GNTTNATTNAAGGACCQWGNNGNCCCCOTvE GGNNTCNNGTTNAAGGNNGGGCCAACAN C⁽^GNANTTNNGGGGCNGGGNTTGNANAATGGCNGTTTTNTTTTTTAACTATACNAGGNT

TTTTCTTTGGTACNGACACACACACANTGAGAGAGGNTNGCNCNTCATATNTATAATAGA TATGAGAGGGGGATATGANAAGCGCTGTGAAAAAATATATTTTTTCTATAACCTCTTTACA CANATCTTGTGANATTTATAGGCHNTATNTNANGTGNGGNNANACANAANNNTTNACAAA NNTCTNTAATGAGACANNTTATCACTCTACATATNTCGTGAAANTTCNGNAAAAAAAANN CGNNNNCNNCTGTCCTNNNAAACANAATATGGGCATNTGTAGAGNTCTNGNTGTTTGGNC

NCANATACCCTTTTAGNAAGAANCAAGACTGTGTTTATAATACTATAACTNTTGTGGACA ANCTCANANAAAATAATTTTTCTTGCTGAAAAAANAATAATAAGGGTGGTGGAAAAAANT ATTATGTTGACGGGTTNTTGGGTTGCTTNCAAAAAACNTNAAAAGGGTGGTGGGTGTTTTT TTTANNAGGAAGAAAAAATTTNTTACTGGCTGCTTTTTNAAAAAAAAA CCTTTTTTTITTNATNAATNAANAAAN^

NAN

AAAAAGCTGGAGCTCCACCGCGGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGGGAGGAGGCGTTGGAGTCACGGGTCAGCGGGAGCCAGCAAGGAGGGGGACAGCCA

CGGAGAGCTGAGGATGAGGATTCGGCCCCGGGCGCTCAGGCTCTCAGGACGNGCCTGTCC CAGGCCCAGCCTNTGAGCTCCAGCAAAGCCCCGACCCGNTGCGGCCNTATTGTCTACTCT GCANACTGTCCGACCCAGGCTNGGNGCTGTGCCTGCAGGAGGGCGGCCCCCGGNATCGNT GANCCACCATNTTAGGACTTGAGAGGCCCGCCTGGGGACCACGAGACNAACCCCCCAGGC TCAGCTCTGGATTCACCGAGGCCCACTCTTGGGGTCGTCTGCTGCTTGGGTCCTTTTCGGG

ACCCCAACCCTTCCAGGCCCTTTTTTGCACACTTTTTCCCCCTTCTTGCCCATNTTCCCCGN ANTGCCGTGCCAGGCCTGAAGGTGGTGGGNTGGTTAAAGGCTNANCCATTACCATTTCAC ACCTGTCCCAAAATNTGATACCCCTGCAAAGGGAAGGGACCACNCTGTTTTCCNAATGAA AGTNTTTNCCAAAAAANACCTGGGTTTNGGNAANAATCCTTTTTCTTTGCTπ (^AAGGNAAAACCCCAATCCTGAAAATNTTTACCCTNGGGGAGGGAAAAAAACCCTTGA

ATTCCNAAAAAAACAAACCCTTAAAAGGGGTTTGGGAGGANGGGANCCTTGGGGCCCTG GNAAAGGCCCCNTTGGGGGCCNTTTGTTTTTCTTTCTNGGGAGGGAAACCCGGGNTTTTCC CCAAGGGGGGGTTTGGGCCCNTITTGNAAAATTNNAAAAANTTNGGGGCCTNGTTTNCAT TGGNAAAAAAAAAAGNTTTTTTTCCCCNGNAANGGGTTTAAAAAGGAAATTTTTT CCC CCCCNAAAAAAAANGGG

TTNANCAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGTCAAGCACACATTTTANGAGAAGCTNCCTGCTCATCT TGTGAAGGTTACTGCTGACCACAAGGAGCAGATGGCTCCATTACTGATGTTAGTGCTTTTC

CAGATATGAGAAGATGCAAGAATTAGGCTCATAAAATCTCCTGAAAATATCCACCTGGTG GCGTGTTCTTCCAGGTTTTCCCAGAGCACAGAGTACCTCGTTCTCGATCTCCACCTTGAAC TCCTTTCAGGGTGTGTTAAGGTCAGTGCCTGCAGTGGCTAGTGACTTAATCCTTGTAGAGG CAGAGGGCGACTGACACTTTTTAGCTGGCAATGGCTGGGATTACACGGCAGAGTCCAAAT TCAGCTGGAGGCCCAGGACCCCCGAGCTTCTCCTCAGAGGACGGTCAGGGCCTCAGCTGC

CAGTGGGGTGGCGACCCTGCCTGTCAGTGGGAAGGGCTGGGTTCTGGGTTCCCCTCTGAA AAGTGGGGTTCTAGCCAGGGAGGCACCCCGTTAGCCCCCTTGCACCAAGGGTAGGAAGGA NGTCCCTGGGANGGACCCTNTGNCTGCACATCAAGNTTTACCGNGACTTTTACTGGAGTC GGCAACACCGTAAATTAAACACGTGCTTNTTTCTNCAATCCANGGTCTTGGGCAGGTGAA GGAAATAGGCCATTTTAAAAAAATGCTTTGNAAGGGACTTTCCCTGGGGGGGCCCAATGG

GTTAAGGAACTTT(^CCCTTTCCAATGCCAGGGGGGGGGCAAGGTTTTGAATCCCCTTGGN CCAGGGGAACTTAAAAATCCCCCCATGGCCTTTGNGGGGCCAAAAAAGGCCCAAATTCTT TNCTTTCCMNAAAGCCCNCC TNNTNAACCAAAAG^ AGGNAAAAAAAAAAAAT TTNNNCACAAGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAATTCGGCACGAGGNTCAATCGCANGTTTTNANAGAANCTGGCTGCNTNT GCAGOSINCTNrWACCG]^

ATTCCATNGGCCATATNTCNCOSfTACTOT

NTGNCTGNTNANTCTNGGTCCTGGAGGANNTGANATTANTAGNANCCTATATAANCCCTT GTACTCCTTTAAGGACC^TNG(^GNAATTGNCTGCNCTNANAAAACACTGNNNN^TNGAT NATGATTNNGGNGATNTGANTCTTCCATAATAGNCAATGGTTGAANAACACGCTTTATGA NCTTATCAGNCCGTNGGOSrTGCAA<_^<^^

ANTTGCNNATGCTGGGAAANNCATNCANNCANGANNCAAGGGTCNGGGANAGCTTTCCC CTTTGANAGATGGGATTGAAGNAAAGAAAAAT(^CCTNGTTCTTNTGTAGCTCCAANGTG AGGAATGGAAAAAACGTGNTNGGCTTCGTATGCCATGCGCACCCNNATTTNCTTTATTNT GNACTGGTTaSfTTTACCTCTGAAAATACCCACAGGACGTGGATAANTTNTTGGCCTTTTAC C<_^GGGAGGAAAAGGGCCAANAAACAATTCAAAACCTTNNCCTTAGGAAGGTCCCTTAA

NTNGNNGGCTTGCCATGGGGTNTNNAAAATTTANCCTTGGCCNCaSlNNGGGGGTTGCCAA TTNGGGAAAACTTTGCCTTTTTGGGNTTNAAAAAA^ NNNCCCNNAAAANTTTTTNTTNAGGGGGGGGCNCTTTTTT^ NN^IN]Sπsπsπ ^ITAACAGTTA NGGNANNTTTTN

TTTGAACAACAGCTGGAGCTCCACCGCGGGGGGCGGCCCGCTCTAGAACTAGTGGATCCC CCGGGCTGCAGGTTCCTGTTAACAGGNNGNTNNANGAGNCATGCAAAACNTCNACACCCC ATAGGGNATGCNNNNNAAGNTATNAANACTAAGAGGAGCTGGCATCANGCACACACNCT GTANCTCACGACNCNTTGCTTAACCACACCCNCACGGGAAACANCAGTGACNAAAATTAT

AGCCATATACGAAAGTTTGACTAAGTTATATTANTTAGGGTTAGGTAATATNTNGTGCCAG CCANCTGCGGNCATACGATTAACCCCNGCTAACANGGAGTACNGCCGTAAANCNGTGTTN NAGCACCATACCAAATAGGGTTAAATTCTAACTAAGCTGTNANAAGCCATGATAACNANA TNANTTANTGA(^ANANGNGACNTTACANTTNCCNGACAGCACTATATNTAAGACCCANA ACTGGNGATTAGNTCTCCATTNTGCCTAANCCTAANNACATTTTATTACATANCACAACAA

TTTNTTC3SITCAGAANTNCTACTATCAACNNNCTTTATAAACNTTANAGGACTTTTGGNGNN NGCTTTTATATTNCATTGTTNNAAGGANGCCTGNNTNTATTNATTCNGANTNAAANCACNC GAT<^AAANCTTTNCCCAATTCNTTNCCT^^ ATCTAANCCTCTAANTTGATAAACAAAAAANNNATAATTNNNNGTGGGNGGGGNCNCNC NNGATC(^(^AATTCTNNNGCTCTNTTTSrGNNNAGTCNATTTTANA^

GTNTCANGNTTTTNNTCNNCTCCNCNANCNCTNTTNNCNCTNTATNTANANGNTCTTGNTN NTANNTlSfNNTTCNTCANTANTATGTNN^

TNCTACNCTGTNσsrTAGTATGNTACGNAGCGCNATTTNTACATNTTCNTAGTNNTGNTGNT NNNCNNTCANNATNGCNNCNGTTGATNCG

CCTATCTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGCGTGAAGGTTGGAGTCTCTCCAGAGAAGCTCCGCTTCCGACAGCACATGGAGAATGA

GATGGCCCATTATGCCTGTGACTGTTGGGATGCTGAATCCAAAACATCCTATGGCTGGATC GAGATTGTTGGATGTGCTGACCGTTCCTGTTATGACCTGTCTTGTCATGCGAGGGCCACCA

AAGTCCCACTCGTAGCCGAGAAACCTTTGAAAGAGCCCAAAACAGTCAATGTTGTTCAGT TTGAACCCAATAAGGGAGCAATTGGTAAGGCGTACAAGAAGGATGCAAAGCTGGTGATG GAGTACCTCGCCATTTGTGATGAGTGTTACATCACAGAAATGGAGAAACTACTGAATGAA AAAGGGGAATTTACTGTTGAAACTGAAGGGAAGACGTTTCAGTTGACAAAAGATATGGTC AATGTGAAGAGATTCCAGAAAACACTACATGTGGAAGAAGTTATTCCAAGTGTAATCGAA

CCCTCTTTTGGCCTGGGCAGGATCATGTATACGGTATTTGAACACACATTCCAAGTTCGTG AGGGAGATGAGCAGAGGACGTTCTTCAGTTTCCCTGCCGTAGTAGCTCCATTCAAATGTTC CGTCCTTCCATTGAGCCAGAACCAGGAGTTCATGCCATTCGTCAAGGAATTATCGGAGGC CTTGACCAGGCACGGCATCTTTTACAAAGTANACGATTCCTCAGGATCCATTGGAAGACG CTTCGCCCAGGACTGGATGAAAATGGTGTGGCTTTTCGCATACCCTTGGACTTCGATCNAG

NGAACCAANACCCTCACACGGGCCCTTTTGCGGGGACCGAGACTTCCTGCCGGAAAATCA NAACCANAAGTCTNTTGAACCTGGCCCATGTTNTCCGCGATTTGGNCAATGGCAACNNCN TTTGGGCGGATNTGGAGGCCCAANN NCTATCTGGAGCTCCACCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCCGGCCTG NAGGTTNAGAAGNGNCCATCTCCCAGACGGCCCTGCANCANAAGACCCTGAGGGTGGNC CTGTGCTCCGTCGGGAANCACCGCAGGNAGGANTGCCTGGNGGAAACTNAGATCAGCCTG

GCGGACCTACCCTTTTCCAGNGGGGTTTTCANTCTGGGGTATAC TNGCTTCTTTCAAAGC ATTGCCTTTGCNAAAAAATAANAGAGGA<^NTGGGNANTCGGTTTCAAACCANCCACCCTT TGGNNTCCCANAAANTNGTTCAGTGACCC^TTTNTNGAAAAAACTTAATGTANTNTTTGG CCGGGAAAANAAATTTCCCCNAAAAAANAACCCGGNGGGAAAAAAAANACACANGNCCC AANNGGANTAGTTNNCCCCTCTAAAAGGCCCTNAAAAAATTTTGGCCCNAAAGNGGCTCN

AAAAAAATTAGTGGNNGGGNGNACTNTTTTGGGNAAAAACACANTCTTCNCAAGTNTGCC AAAANAAGNGGGGCCCCACCAGGAAAAAAAA(^GTTNGTGCNAAAAACTNTNNTAACAC CCCCCCCCCCAGNAAAAATNCTCTTNTTGGTNTAAAAANAAACCCCCCCCNNNCCCGGGC GGGGGNNCCTTTTTTTTTTNCCCCCNAAAAAAACAAAANNTTNNT^^ CNTTTTTTTAANAAAAAAANAAANTTGGNN(^TTCCAAAAAAATNTTNC^

GGGANNCCCANNNCNNNNNGGGGGGNANNNNTNAAANNGGNNGGGGNNNGGNNNNCCC CNCNNNTTNINAAAAAAANNTTTTNTO^

NAAAAAANNGGGGGGGGGNCCCCCCCCCCOSINNNNGNNNNNNNTSfNNNr^^^ NNNNNNTSINNNNNNNNNNCCNNGGGNNNNNNNNN^

GCNCTATCTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTCGTCTTGGAGGTGACTCGGCGTGATTGAATTTGCGGCATCTTCGCATTCACTCA CAGGTCAAAATGCAGATCTTCGTGAAAACCCTGACCGGCAAGACCATCACCCTGGAGGTG GAGCCCAGTGACACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAGGAAGGCATTCC

CCCTGACCAGCAGAGGCTCATCTTTGCCGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCT GATTACAACATCCANAAAGAGTCGACCCTGCACCTGGTCCTNCGTCTGAGGGGTGGTATG CANATTTTCGTGAAGACCCTGACCGGCAAGACCATCACCCTGGAAGTGGAGCCCAGTGAC ACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAGGANGGCATTCCCCCCGACCAGCA NAGGCTCATCTTTGCCGGCNAGCAGCTGGAAGATGGCCGCACTCTTTCTGATTACAACATC

CAGAAAGAGTCGACCCTGCACCTGGTCCTCCGTCTGAGGGGTGGNATTGCANAATCTTTC GTGAAGACCCTGAACCGGGGAAGACCATNACCCTGGTATGTGGAGCCCANNTGACACCAT CNAATANCGTGGANGGCCAANATCCAGGATAAGGGANGGCATTTCCCCCTGNACCAANC ANANNNCTTAAACTTTTNNCCCGGCCAAGCAGCCTNGGAANANNGCCCCGCANCTCTTTT TNTGGTTTNCCNACANTTCCANGAAAGAAGTCCGACCCCTTNNCNACCCTGNGTCTTNCNT

NCTNNAGGGGGGGGNNTNCCATNATNCTTNCTNGNAATGACCCTTGNCCGGGGNANAAA NCATTCTCCCC^TNGNANGTGGGANNCCCANTGGATCNCCCTCTCNNNNAACCTNNNANG GCCCCNTAATCCCCNGNANN

ANCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAAGTGGATCCCCCGGGC

TTTNNNAAAAAAANNNTTTTTCNNGGGGG

N INNTTTCCGGGAAGGGGNGGNAANNNCNTA INTTNNCCCNGGCNNNAAANTNGCCCTT TTNANCNNCCCCCOSiNNTTTTTTTTTNATTTTGG

NGCACCGATTTTTMAAGGGGNAAAAGGGNTNTNAACTTTC^

TNNGGGGGGNNGNGAAAAAACGCC(-^CNNTTTTTTTTT^^ NAAAAANGNTNTTTTCTGNGNCAAGAC(^GGGGGGAAAACCCCCNCNTTNACAAAAAAA

TTTTΓTNGGCCCCCCNCNGGGC^CNTTTΓTTTGNNAAACCCC

GGGNGGGGCCCCANTTNNCCNNTAAAANGGGNGGGGGNNAA

NNNNAACTTNGNNΑSINNNNCOSINNNNNC^

GLSINR^NNCCNCCCNGGCCCNGGGNNNCMWANNN^ NNGGGGAGGNCOSTNNANNNNNNN^

GCCNGNNCNNGGNAANCCCGGNNNNNNGGNCCCCNNNCN ANCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAAGTGGATCCCCCGGGC

TGCAGGGTTTTTTTTTTTTTTTT^

TTTNNNAAAAAAANNNTTTπOWGGGGGG

NI^NNTTTCCGGGAAGGGGNGGNAANNNCNTANNTTN^ TTNANCMSTCCCCCCNNNTTTTTTTTTNAT^

TNNCGGGGGGNNNGNTTTTTTTTNCCANN^

CCCCCNTNCAGGGNTTTITTTNGGGGGGGαNrCCC^

NGCACCGATTTTTTNAAGGGGNAAAAGGGNTNTNAACTTTCCNCCCNTTTNNNG

TNNGGGGGGNNGNGAAAAAACGCCOSrCNNTTTTTTTTTTNN^ NAAAAANGNTNTTTTCTGNGNCAAGACC^GGGGGGAAAACCCCαsfCNTTNACAAAAAAA

TTTTTTNGGCCCCC(^CNGGGCNCNTTTT^

GGGNGGGGCCCCANTTNNCC INTAAAANGGGNGGGGGNNAANACNNNNNNNNNAAAAN

NNNNAACTTNGNNα M^NNCCNNNNNN<^C(^T^

GNNNNNCO ^'CC(^GGCCCNGGGNNNCNNNANNNNCαsπsrCCNGCNN NNGGGGAGGNCCNNNANNNNNNNNNCNNGGANNNNCCCCCCNCNCNNCNANNANGGGN

GCCNGNNCNNGGNAANCCCGGNNNNNNGGNCCCCNNNCN

AAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAACAACGCCNTGNTNNTNNTNNNGAANNGGANCNGGAAAGC

CαsfNNNCGNATNCGANNTNANGCTGANCGGGACCGACTCACAGNNNNNACNAANGCAGC CTGATGTNACACATNGNNACCCATNATNNTCTACTGTCNCAATCNACATGTACCANNANG CATGNGCCNAGCNGTNTANACCTTGATCAAGTTAATGCTATTGANGCTANAGGNTACACN TTNTCANANCCTGANCNAGGGCCTTGGGAAGNANNTGCGNAANCTNCNAANNGCCATTN NTTCCNCGCCGCNGATACAGGGCGAGTACATGATCCNGTGCGAGAAGGNNNCCANCCTGC

CTTANGTNACCGTGAAACTGGGGGGTAAGGACTACGCGCTGTCCCCANAGGACTACGCGC TCAAGGTGTCGCAAGCCGGCACGACCGTGTGCCTGANCGGCTTCATGGGCATGGACATTC CCCCGNCTGGCGGGCCGGTTTGGATNCTGGGCGACGTCTTTATNGGGCGTTACTACACCGT GTTCGAACGGGAACANAAACCGGGTGGGCTTTGGNCCAAGGCTGGCCCGGTTTTAACTTG GCCCCCGCTTACCTGGTTGGANTNCAAAAGAAGAAGGCGGCCCAACAAAAAAAACCAAA

AAAAGNANAAAAAANTTTTTGCTTAAAATTTGACTTTCNAGNTNGCAACCAAAANNCCCG ATTATTTCCCAAGGGCCCNTNGGGNCCHNAATTTNGGGTTTCCGGGGGTTTCCCCCTTNCC TTGGGGGCNNNAAAAAGCCNGNNTTGCNNGGGNCNNGGCTGGGCNTGGNCNGGNNNGAA AGGGGGAAGGGNAANCCTTGGAACCCCAAANTTGGGGGGGNAAANTTTCCGGGGGGCNC AAAAAANCCCNTTTTTTTTTAAATTTGGNAAAAAACN

TTNAACAAAAGCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGGTGCTCGTCCACTGATATCAGNGNACTCCGAAAAGGGG GAGTCCTCTGGCAAAAATGTCACTTTGCCTGCTGNGTTCAAGGCTCCCATTCGACCCGATA

TTGNTAACTTTGTTCACACCAACTTGCGCAAAAACAACANACAGCCCTATGCTGTCAGNG AATTANCAGGTCATNAAACCANTGCTGANTCTTGGGGTACCGACAGAGCTGTGGCTCGAA TTCCCAGGGTTCGAGGTGGCGGGACTCACCGTTCCGGCCAGGGCGCTTTTGGAAACATGT GTCGTGGGGGCCGCATGTTTGCGCCAACTAAGACCTGGCGACNTTGGCACCGCAGAGTGA ATACGACGCANAAGCGATACGCCATCTGCTCTGCACTGGCTGCCTNAGCCTTACCAAGCG

CTGGTCATGTCTAAANGGTCATCGTATAGAGGAAGTTCCTGAACTTNCTTTGTGGGNGGA AGATAAAGTNGAANGGCTACAAAAANACCAANGAGGCTTGTGTTGCTTCTGAAGAAACTT AAGGNCTGGAATGATATCNNAAAAGGTCTATGCCTCTCANCGAATGAAANCTGGCAAAG GCAAGAATNAAAAACCCGNGGCCGTATCCAGCGCANGGGACCCTTGCNTCNTNTATAATG GNGGACAATGGNTTCATTCANGGCCTTCAAAAACATTCCTGGAATACCCTGNTAAAGNAA

NCAACTTNACANTTTGNAACCTGCTTCCTGGGGGCACOSfGGGAACTTTTTTCTT^ AAAAGGCCTTTCCGAAAGTNAAAAAAACTATTTGGGCCTTGGGNGAAAANNNNCCTCCTT TAAAAAAAAαSfTTNAACCTTNCTTTTNCCNAAAAA

TNNNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCCGCCATGGGCCGCGTGATTCGTGGGCAGAGGAAGGGCGCCGGCTCCGTGTT CCGCGCACATGTGAAGCACAGAAAAGGCGCCGCGCGCCTACGCGCCGTGGATTTCGCCGA GCGACACGGATATATCAAGGGCATCGTGAAGGACATCATCCACGACCCGGGCCGCGGAG CGCCCCTTGCCAAAGTGGTTTTCCGGGATCCGTACCGTTTTAAGAAGCGGACAGAGCTGTT CATCGCTGCTGAGGGCATCCACACCGGCCAGTTTGTGTACTGCGGCAAGAAGGCCCAGCT CAACATCGGCAACGTGCTCCCGGTGGGCACCATGCCTGAGGGCACCATCGTGTGTTGTCT GGAGGAGAAGCCTGGTGACCGAGGCAAGCTGGCAAGAGCCTCTGGAAACTATGCCACAG TCATCTCCCACAACCCTGAGACAAAGAAGACGCGAGTGAAGCTGCCTTCGGGCTCCAAAA

AGGTCATCTCCTCTGCCAACAGAGCTGTGGTCGGTGTGGTGGCTTGGAGGTGGCCGCATTG ACAAGCCCATTCTGAAGGCCGGCCGTGCCTACCACAAGTATAAGGCAAAGAAGGAACTG GTTGGCCCCGGGTGGCCGGGGTGTGGCCATGAACCCTGTCGAGCATTCCTTTTGGANGNG GCAACCACCAACACATTNGGCAAACCCTTTTATTNTTTGCAANAAAACCCCCCTTGCTGGG CCCCGGAAANGGGGTTTTTATTTGTTGNCCCCCCCGGAAAAGGCCCTTTTTCNGGGGAAAC

CCAAAAANTGGGC(^GGAAAAAAGGAAAACCTTGGGGTTGGGGCTTNAAAAAAAAAGTT TGGTTTTTTTTCCCACCTGGGAAAAAAAAAAAAAAAAAAAAANCTTGGGGGGGGGGGGC CCGGNCCCCCCTTTT

TNNNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCCGCCATGGGCCGCGTGATTCGTGGGCAGAGGAAGGGCGCCGGCTCCGTGTT CCGCGCACATGTGAAGCACAGAAAAGGCGCCGCGCGCCTACGCGCCGTGGATTTCGCCGA GCGACACGGATATATCAAGGGCATCGTGAAGGACATCATCCACGACCCGGGCCGCGGAG CGCCCCTTGCCAAAGTGGTTTTCCGGGATCCGTACCGTTTTAAGAAGCGGACAGAGCTGTT

CATCGCTGCTGAGGGCATCCACACCGGCCAGTTTGTGTACTGCGGCAAGAAGGCCCAGCT CAACATCGGCAACGTGCTCCCGGTGGGCACCATGCCTGAGGGCACCATCGTGTGTTGTCT GGAGGAGAAGCCTGGTGACCGAGGCAAGCTGGCAAGAGCCTCTGGAAACTATGCCACAG TCATCTCCCACAACCCTGAGACAAAGAAGACGCGAGTGAAGCTGCCTTCGGGCTCCAAAA AGGTCATCTCCTCTGCCAACAGAGCTGTGGTCGGTGTGGTGGCTTGGAGGTGGCCGCATTG

ACAAGCCCATTCTGAAGGCCGGCCGTGCCTACCACAAGTATAAGGCAAAGAAGGAACTG GTTGGCCCCGGGTGGCCGGGGTGTGGCCATGAACCCTGTCGAGCATTCCTTTTGGANGNG GCAACCACCAACACATTNGGCAAACCCTTTTATTNTTTGCAANAAAACCCCCCTTGCTGGG CCCCGGAAANGGGGTTTTTATTTGTTGNCCCCCCCGGAAAAGGCCCTTTTTCNGGGGAAAC CCAAAAANTGGGCCNGGAAAAAAGGAAAACCTTGGGGTTGGGGCTTNAAAAAAAAAGTT

TGGTTTTTTTTCCCACCTGGGAAAAAAAAAAAAAAAAAAAAANCTTGGGGGGGGGGGGC CCGGNCCCCCCTTTT

CNNNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGANGACATNNNACTGα^NNNTTATGNGTGCNTTCCTGGCTCCT GCCCTNGGGNANGNTGCGAATGCCNTGNANCANCTGGANCGNNATGACCGTGANCTTGG GCGTGGAGGACCATATNACACCATCNTANACNTNTATGGNGGAAGGCATGCACAAANNN NNCTGGCCGACNAGGACCAGCAACAGGCTGANCTTTNCCGNCACACAGGGGCGTGATACT NNCTATCTGTNANACTACACCCTACGANATGAGGTGGCTCTGATCTTGAATCTGNTGCTGN

ACAT WGGCNGTGTTNGNTTNTTATTTN^

TCACTNCATATGTTGCTTTCGATNTAATNTTGACAGCCAGTACNGGGGNCCCCGNNCCCGT TATNTATNTCCAAAANNCTTGGGAAAAAAGNGTAATTNGACCAAAAAAGGATATTTGTTT TTGCTATTACACCAAATACAGTTCANATGCTTATTGTTCTATTTTTTTACCAATTTCAATTT CAAAATGTCTCANTGGTGCTATAATAAATAAACTTCANCACTCTTCCAATAACACTGCGTT

ACATTCTTTGAATCCTANCCCATTTTCAGAGCAATTGACGGTGCTTACCATTAAAAAGATT ACCTTNCTTTTTGAAACAGTCAAGCAAGAAATTAGAAAAGAACTTCTGTTTCAACTACCTT AACCTGGGCAGAAACATAANGAATTCTATGAGNCCAAAAAAAGAAAAATTTGNCCNAAA NGCCCAAAACTTACGNTCCTTAAATATGGGTTTAAAAAAAANTNGAACGGNGGGCAAGA AATTAAAANAAATANTTT GANNNNCC(^TTATATCTTGAAANTCAACTGGTTπ

GGGCTTI NTTTTTTNNGGNCATTGGNGGGCAN

GCCCTATAGTGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCGGGC TTGCAGGNNTNAGAACTCAGNCCCCACANTGNNCCNNCGGTTACTTACTGGCTTGNCCCT

AACα KGGATGGAACTNTGGATGCTNTCNNAGCANACTGGGGATTTCTNTACTGNCNAAN ACCTTGCATTCCGGGGCTCAAANCTNAAAAACCTCCGATNCCAAAGACCTGGTNCCANAA TGTCCANGGCCAAAGAACCAATGTNTGGNNNNGAGAANCTNTCANCNGTGGNACCCAGT TNNAATTTAATGTTNANGGATTNACCACCANGGAAATGNNTACCCAACTTGCCTTCATGC GNNNGTTGGCCAACCATGCCTATTNCANCATCACCTACCATTGGGAAGAACACNATTGCT TACNTGGATGAGGAAACTGGCAACCTGAAAAAGGCTGTGATTCTGCAAGGATCCAATGAT GTCNAACTTGTTGTGCGAGGNGCAACAANCAAGATTCACTTACACTGTTCTTGTAATANG GCTGCTCTAAAAAGACTACTGAATGG(^TNAGACAATTNNTTGNATTTAAAACAAACANG CCATNTCGCCTNNCTATCCTTGAAATTTGCACCTTTNGGACCCTCGGGTGGGCGCTTGACC

AAGGAAATCAGATTTAACCTTTTGGCCCCGGTNTGTTTTCCAATAAAACTAAACCTTNTGN CCTTAANTTTGANAAGNAJSIAAAAGGGGAAAATNTTGGAACCANTTTCTTNTTGGGCCCTT TTSINGATTTTTTGTTNCTTTTCC^AACCTGGAAAATGNTGAANANCCT^ NGGCNCCANTTTTTTTTTGNTTAAAAANTGGTGGGGCCC(-^AAANAAGNGGGAAANGGCT TTGNTTCNAAAANCTTTTGTGGCC^TTAANCAATTTTAATTTCNCCTCCCNCCCTCCT^

ANCC^CNTTACAAAAAAAATTTGGGANTTTT^^

GGGNAAAAAGGTCNQWTTTTNGNAAAANATCCCNAAAAAANTTNTGTAAAANACTACC CCCNNCT

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC - AGGCGCAGGATCAAGGTGAGAAGGAGAACCCCATGCGGGAACTTCGCATCCGCAAGCTC TGCCTCAACATCTGCGTTGGGGAGAGCGGAGACAGGCTGACCCGGGCAGCCAAGGTGCTG GAGCAGCTCACGGGCCAGACCCCAGTGTTCTCCAAAGCTAGATACACTGTCAGGTCCTTC GGCATCAGGAGAAACGAAAAGATCGCCGTCCACTGCACCGTCCGTGGGGCCAAGGCGGA

AGAAATCCTGGAGAAAGGNCTAAAGGNGCGAGAGTACGAGTTAAGAAAAAATAACTTCT CAGATACTGGAAACTTTGGCTTTGGGATCCAAGAACACATCGACCTGGGGATCAAGTATG ACCCGAGCATCGGTATCTACGGCCTGGACTTCTACGTGGTGCTGGGTAGGCCAGGTTTCAG CATCGCAGACAAGAAGCGCAGGACAGGCTGCATTGGGGCCAAACACAGAATCAGCAAAG AGGAGGCCATGCGCTGGTTCCAGCAGAAGTATGATGGGATCATCCTTCCTGGCAAATAAA

TTCCCGTTTCTATCCAAAAGGTCAATAAAACATTTTCAATGAAATGTAAAAAAAAAAAAA AAAAAAAAAACTCGGGGGGGGGGCCCGGGGNNCCCCAATTTNCNCCCTTTTTNNGGGGN GGGGGNTNNAANNNNNNNNNN NNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNTSπSIN^ Nτ>πSfNNNNNNNTNNNNNNNNNNNNNN^

NlSINNNNlSπSfNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNC

AANACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGAAAATCTCACATTTGATGAAATGTATTAAGCATAAAGTACTAGTCTGTGTCTATGCATA TGGGAAACAGTNCTAACCAGGAAAATNN(^CTGαv GNCNGNCATTTTTNGTTTAAAANC NGGGNNTNGNCTNGAATAACCANNCCNTNAGGGNNTTTTANCCNNGTAAANNNGNNTTN AAAAAANT^TNGTNGCCNNGGANNAANGGGCNNNAAANTTNT^INCNANCTNNTANNTNA NGGCCCAGGGCCNGANCAAACCAGGGNNAACNNNNGAGAACCGCGNTCCTNTGTACCAN

GGGGTGGCACANGTGTTGTNACACCCTGGGGTTTCCTTCTNTTATATAAGGGAGAGAGAA AAAANATGCGCCCACACANNACAGATATNCCTTCCACGCGCGCAGTTNTTGATACNCCAC NCNNTGTNTGNGGOSπSINNACNCNNNNACNTGCCCCCTNGGGTNTAAAAN^ CGCATCTNTATTTTCTGANACTCTCNTNTGTGTNANGACANTGTTTTTNNAAGAAAATGAG GACACCCTATNGGTAAANCCNCTGATGAGTGTATANACCCCTCCNTGGGGGTCTCNTGNG

CGCTTCAAGCGCCCCCTTTCCCCACCNCCCCATGNACCANTGNGGGNGGNNTCTGTNAAA AAAAATCCTTNTCTCT INCNCCCCCCCATTTTNTNTTTTNNANAACNCCTTGGGGGC CNGCCGTGGNGGNCANAGNACTTCCCNGOSINGGTGGNTTTTTCCCCGGGGGGGGGGCNAC AACCAGCCCNNGAAANAACCCCCCNCCTTCAAAAAAGGAGGGTGCTTTTTTNAAAAACCC CCNTNTTTGCCCCCNCNNC

AANACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAAAATCTCACATTTGATGAAATGTATTAAGCATAAAGTACTAGTCTGTGTCTATGCATA TGGGAAACAGTNCTAACCAGGAAAATNN(^CTGσWGNαSfGNCATTTTTNGTTTAAAA

NGGGNNTNGNCTNGAATAACCANNC⁽TNTNAGGGNNTTTTANCC WGTAAANNNGNNTTN AAAAAANTTTNGTNGCOSINGGANNAANGGGαSINNAAANTTNTNNCN NGGCCCAGGGCCNGANCAAACCAGGGNNAACNNNNGAGAACCGCGNTCCTNTGTACCAN GGGGTGGCACANGTGTTGTNACACCCTGGGGTTTCCTTCTNTTATATAAGGGAGAGAGAA AAAANATGCGCCCACACANNACAGATATNCCTTCCACGCGCGCAGTTNTTGATACNCCAC NOWTGTNTGNGGCNNNNA(^ΑSINNNACNTGCCCCCTNGGGTNTAAAANAGN(^ CGCATCTNTATTTTCTGANACTCT(^TNTGTGTNANGACANTGTTTTTNNAAGAAAATGAG GACACCCTATNGGTAAANCCNCTGATGAGTGTATANACCCCTCCNTGGGGGTCTCNTGNG CGCTTCAAGCGCCCCCTTTCCCCACCNCCCCATGNACCANTGNGGGNGGNNTCTGTNAAA

AAAAATCCTTNTCTCTNNCNCCCCCCCATTTTNTNTTTTNNANAACN CNGCCGTGGNGGNCANAGNACΓΓCCCNGCNNGGTGGNTTTTTCCCCGGGGGGGGGGCNAC AACCAGCCCNNGAAANAACCCCCCNCCTTCAAAAAAGGAGGGTGCTTTTTTNAAAAACCC

CCNTNTTTGCCCCCNCNNC

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGAAGACAAACCCACACGTCCCGGTGGTGGAAACACCC CATGAGGGCGCATCCTCTTCTCCTGGTTAGTATTTATTTCAGCACCTGGTTAATGCGGTTTT TTATTCTCTACCTATTGCACTGTTGTGACTTGTTGGCCATTATTTGATTTTTGTACGAAAAA

AAAGCTTTGTTATAGAAATCAGCATACTATTTTTTTAAACCTGGAGAGAAGATATTATGGT GACTGAAAATATGGTCAGGTGTCAAATATAAATGTATAAAAGCCTTCTTACTGGNCCTGG CTGGTCATGGTACAATTAATTTATATTGGCTGGCCAATACTGAAGGTTCTTTTTCGGTTGG GGAAACTCTAATTTCTATCACNGNGGCATGAAATTTTAAAATCAGGATTTCATTACAGGTG GNCTCAACANTGGGAAACTTAATTTTGGCNGGANCATTATTGATCAAGCCAAATAAANTT

CAACAGNCCTTTGGAGGGANAAAAAAAAAAAAAAAAACTGGGGGGGGGNCCCGGNCCCC AATNNNCCCTAAAGGGNGNGGGNNNANANNNNNNNNN^

NNNNNNNrWNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNCNNNNNNNCNNNNNNNNNNNNNNNNNN^

NNTSINNNNNfNNNNNNNNNlSπSINNNNN^ CNNTSINNNNISINNNNTWNNNNNNN^ C

TTNAANAAANCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCNCCACCCCAGGCTTGGACAATGGGNGGGGACATGNTCA ACGCCAGGTTCATTCGAAACTTGCATGAACGTNGCAGCACCAGGCCTTGGTGACCGCAGC CCCCTCTCACACCTTCAAAATCATTATTATTTCTATCTCACACANGACTTAGTCAAAGCTTG CCCTCGCCGTGTATGTATTCATTCATTCATTTATTCATTCTACAGGCTTTTTTTT^

NANNGCCAAGTCATTNNAATNTTATTTTTAAC^

GAAAAAAAAAAAAAAATGATTNGGGGGGGGGC(_^GGGCCCCNNTTTCCNNTNNNANNGA TCAGAANNAAANGNGAGNGGNTNCCCNTTNCCNAATGNNNGCTTANAANAANACTTTGT AANNTNGCNCCATNNANCNTTTACANNGGTCNCTTNTTAAANNNAANNTTATGATTNNNA GNNTTNCNCCCNNAATANAANGAATATNCCAGTCCNAAGNNANAANCTTTAAAANNAAC

TNTTCNNTGGGGGCCCAGGNATANTANNGNGAC WTTTNANAGNNAAANAANTNNNTNT NNGGNCNT INCCTNGGGNNNAACNTTN<^G^

NCCTNNCTCCGTANGNNNAANNNNNGGNNNNMNTANAACANNNNNNTTTπ TNGGNNNCCCAANNNNNNNNNGGNNNNA INNTTTNACCCCTNNNNTTAAANN^ NANTTTNNNTNTTTNNNNNNNCCGNNNNAAAANNN^

NNCNTNTNNNNNNNTNTNAANN^ NNNNNNNNNNNNNNNNNNGGNNTTNGNANGGGNNCCCN

TNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATNCNNCNCNAGGGNTNNCNGTTNNNNGCNNNTGNTTTCANCANACANAT GCTATTNATTNNGGTGGGGGTNNANGCNNTNNCNNTNCTGNATTGCATGAATGCTTGNCA TTGGACATTGANANACATTCTTNAANNACTGAACCNNTGNAGGAGAAAGTNNAANNNNT NGTCACACNGNACATGNGATGACTCTANTGCGATANCATGGGCTGNAACCTGCCAGGCTG ATAANGTCCNNTGTATTNNCCAGNAAGAATACTNGGGTGCTTTCCCTATTCCTTTGCNGAN

GGGACTTTANTNANCCAANGATCNAA<^CNACTCNNNTGGTTGNGGAGGGCAATNTTTTN TGNCTGACTCANNACAGAATTCNCGNCGTTACGGTGTACATTAANTGGAGNGCACATCTA CCACTTTATGGCCGNAGAGAAATGAGCNAACNCGTCNCTGGGNAANNCAAGACTAGGGA ACTGGATGCTACCANGAANANGGANGATCTNTACCCATTTTCCTAGTTCGANTGCAATNA TATNNCATTCCACTTAGCCGGAAGACGACATANGAAGNGCTTGCGCNαSfCNCCTTTTGGA CCCNCGGAAACCTGNCTTANCAGGACCTTTCCGTTGTAAACACNCCCGGNCCCGGAAACC TTTGGTTNCGTTTGACATATAGCCTTTGGAAAAATGAAGGACTNGNTAGNANCCTGGGCN GTNAAAAANATTGAACAAGTTTNCCAANNGGGGGACCCNCCCCCCCCGAANCTTGAANCC TTTTTTTAAAGGGGTTTTTTTCAAGAGTGGNCAAAAAAAACTTCAAGGGGGCAAACCCGT^

TNTAANAGTTGGGTCAANCATTTTGGAANCCAAAATTTTGANTAGGGGGANAAAANCCTC GNAAAAACGGGGGGNGNCCTTTATTGAACCCCNCCCGGNNAAAAAAAAANTNNTNTTTTT TNAAAGGNTANTTTTNTTTTNT

TNNNNCAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGTCAAAAGACCCCTTTCATCACCAACCCTGGGTATGACACTGGAAACGGTATT CAGCTTCCCGGCACTTCTGGTCAGCAGCCCAGTCTTGGGCAACAAATGATCTTTGAGGAGC ATGGTTTTAGGCGAACCACACCGCCACCACGGCCACCCCCGTAAGGCATAGGCCAAGACC GTATCCGCCGAATGTAAATGAGGAGATCCAAATTGGTCATGTCCCCAGGGGAGACGTAGA

CCATCATCTCTACCCTCACGTTGTGGGACTCAATCCAAATGCTTCTACAGGCCAAGAAGCT CTCTCTCAGACAACCATCTCATGGACCCCATTCCAGGAAAGCTCTGAGTATATCATTTCAT GTCATCCAGTTGGCATTGATGAAGAACCCTTACAGTTCCGAGTTCCTGGAACCTCTGCTAG TGCCACCTTGACGGGCCTCACCAGAGGGGCCACCTACAACATCATAGTGGAGGCAGTAAA AGACCAGCAGAGGCAGAAGGTTCGGGAGGAGGTGGNTACCGTGGGCAATTCTTGTTGACC

AGGGCCTGAGTCAGCCCACAGATGACTCCTGCTTCGANCCCTACACGGGCTTCCATTATGC CATTGGGAAAAGANTGGGAACCNATTGTCTGATTCTGGCTTTTAAACTCTCGGGCCCATGG CTTAAGGCTTTGGCAGGGGTCANTTTCAAAATGCCAATTCAATTTAAATGGGGGCCNTTGA CAATGGGAGTGGAACTACCAAGAATTGGAANAAAAAAGNGGGNATCCGTCANGGGAAAA AAAATGGGCCAAAAANAATNAANCTTGNCCCTTTTTTTTGGGAAAANGGGAAAANGGGA

AAAATTCAAGNGNGGAATCCTTTTTGGAAGGN

AAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GAATTCGGCACGAGGAAGCCATGTTAATGTACTATGTATTTACCCAAGACTCTCTCTTCAG

GTCGGTTCCCCCTAAAGGCTCAGAACCGACTCGACAAACCAGTATGTCTTACTCACACCTG GTTCTCCTAATCTATGTTAATGAAACTATATTTGCTTGGAAATCCACCTTTCTTCAAGATTC ATGTCAATCATTTTATGGCCCGGATGACTCACCTGCTGCCAATGTTATCTCAATGCATGTT GCCGGTGAGGGGCCTGGTGCCATTCTCTGAGACGTTGTCTTTCTTTAATTAGCAGACTGCT AGTGGCTGTAAGTGAAAGTGAAAAGTGAAAGTGAAGTCGCTCAGTCATGTCTGACTCTAG

CGACCCCATGGACTGCAGCCCACCAAAGCTCCTCCATCCACGGGATTTTCCAGGCAAAAG TACTGGAGTAGGGTGCCATTGCCGCAACATGCTATGGCTCTTCAGAGGAGAGACTGACTA TTTAAGGAAATCGCATGTTTAAAAGTAGTTTTCAAAAAAAAAAAAAAAAACCTCGGGGGG GGCCCGGGNCCCATTNCNCCCTATNGGGGANGNNNNANAANNNISINNNNTSINNN^ NNNNNNNNNNNNNNNNN^

NNNNNr>[NNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNTSIN^ NNNNNNNNNNNNNNTSπSINNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNC

AGCCCTATAGNGAGTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC CTGCAGGAANTTCGGCANCGAGGCTCGCTTGCAGTTTAACCTGTCCCTGTACTGGAGTCAC GAGGCGCTCTTCCAGAAAGAAAGATCCTTGCAGGGCCCTGGGAGTTCCACACCGTGCCNT

TTCGAAGCTGGNTGGGNTTCAATACTGGGGCCTGAACCTTCACTGAGGGCACNTACCAGC CCCGGNTTTACACCTCGCCCACCTGGAGCCAATCCGGGATGAAGCTCCAGTTACAACCCCT CCCGGTCCTTCCAAACCCCCCAGCACCCCAGCTTCCTTTTCCATGACAGCTCTGTCTCCTGG NCTTTCGTCTACCTCCCTACCCTNCANAGCTGGTGGAACTACGGGTTCTCGNGCTCCTCTG ATGACCCCCCACTCCTGGCTNTTTCCAAGTNCAGCTNCTCCAAGTCCAATCCCACCATTGG

NTATNAAAACCGGGCCCTGCTGCACTGNNAGGGGAGCTTTGGGGTAAAACGTTATCGACT TNAAGGGGCTGGAAGGCCCTTGGTCCCCAAGTGCCCCTGGCTACCAACAGCTTCANGGAG

CCGNCC€TTTTTACCTGACCCAACTTCNACGGAACATGGGACTAANAACTTCGGAGGGGT GGAATTTNAAGGGNNGGGGCAAGGAANNTTNATNGGAGGGNTGGGGNACCCTNCCCTTT

CTTTAACCTTTTTTTTTTGGANGCACCCTTNAANTNACCGGGCCAACANGGGGGCCCCCCT

TTGGTTTNNGNTGATTTTTNTNGAGCTANNGGAAATTTGCGGGGAAAAAATT^

TNGNAANCTTTCCTNGGGGGGNTTAGGGGGNAAAAAAAANTTTT(-^TNTANAGNAAAAA

AAAO WGNTTTNACCCCTGNGNNGNTNAGGGANCCCCNGGGAANAANGNAAAACCCCCC

(^TCCNCMNTTTNGGCTAGAAAAACT

NAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCGGCGGCGAGATGTCCGGAGGATCAGCTAGGAGCCTGGGCAAGGGAAGCGCCCCC

CCGGGGCCCGTCCCCGAGGGCCTGATCCGTGTCTACAGCATGAGGTTCTGCCCGTATGCCC AGAGGACTCGCCTGGTCCTGACGGCCAAGGGTATCCGGCATGAAGTCATCAACATCAACC TGAAAAATAAGCCTGAGTGGTTCTTCAAGAAGAATCCCTCAGGCCTGGTGCCGGTTCTGG AAACCAGTCAGGGTCAATTGATCTGTGAATCTGCCATCACTTGTGAGTACCTGGATGAAG CATATCCAGGGAAGAAGCTGTTGCCAGGCGACCCCTATGAGAAAGCTTGCCAAAAGATGG

TCTTGGAGTCCTTTTCTAAGGTACCACCTTTGATATTGAAGATTCTTAGAACACAAAATAA GGAAGACTGCTCTGGCCTAAAAGAAGAATTGCATAAAGAAATCACCAAGCTAGAGGAGG TTCTGACTGATAAGAAGACAACCTTCTTTGGTGGCAATTCTCTTTCTATGATTGATTACCTC ATCTGGCCCTGGTTTGAACGTCTGGAAGCTCTGGAGTTGAATGAGTGTGTAGACCACGCTC CAACTCTTAAAGCTGTGGATGGCAGCCCATGAAAAANGATCCCACAGTATCATCTCTTCCT

CACTGACGTGGAAGAACCCTTTCAAGGGTTNTTTCAACCCTCTACTTGCAGAACAGCCCCT TGAGGGCTTATGACTATGGACTCTGATGGGGGACGAGTTCANCCAATGAAAAACATAACT GGANACTTTTCCTTTCCCTTAATAATGAAATAAATACCCNTGGGGTTTTATTTTπ AAAAAAAAAAAAAAAAAANCCTCNGGGGGGGGGGGCG

AANACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTGCAG GNAGNGGNTGTGTGATTGCGTCCCGNAANACCGGNAGCGCTTGCNCATNGNTGACCAACT GNCTGAANAACANATTGCAGAATTCNAANAANCTTTTTCACTNTTTGNCCAGGNTGGGGA NGGAACTNTTACNACNAAGGNATTGGGAACNGNNATNNAANNTCTTGGGCNNAATCCCA αSINAANCNNANNTACCGGACNTNANTAATGAAGNGGATGCNNATGGTAATGGCACNATT GACTTCCCGGAATTTCTGACCNTGATGGCAAGAAAAATGAAAGATACCGACACGTGAAGA AGAAATTATGAGANGCATTCCGTGTGTTTGATAAANATGGTNATGNGCTATATTAGTGCA GCACANCTTTNCCATGTGATGACAAACCTTGTNGANATGTTANCNNATGACCAGGNTNAT GANNTGATCNGGGGACCAGANATNNNNGGTGANGGGNACNTCTACTATGGATACNTGCC

ACATGATGACANCNNAATGAAAACANTNTACACAATGTGGTAAATNTCTTGTANCACNAT TGNACNTTTGCCTTTTCTTTTGTTGNGTAACTCATCTTGTAANAANGTGTNCCCCTTACTGC CAAAAAAAAAAATATCCCTGTNTTAGTANATTAAGGACTTCCTTTCCTTCCATGGTGTCTT NCC⁽^TATTNTTACTGGC(^TTTGTCCTGGAAACCTTTNTTTTTAAAAAA^ GTAACATGGTTGCATTGGGGGCTTAACTCTGGGANAATATTNTAAANCCCCTTCTTGCCCC

TCTTAAACTTTAAAANGGAGGGNGGNTCAAANNGAAGGGAACCAACNGGGGGGNANTCC CNTNTTTTTTTTTTTTTTTGAAN^ NAAAAANGNN

AANACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTGCAG GNAGNGGNTGTGTGATTGCGTCCCGNAANACCGGNAGCGCTTGCNCATNGNTGACCAACT GNCTGAANAACANATTGCAGAATTCNAANAANCTTTTTCACTNTTTGNCCAGGNTGGGGA NGGAACTNTTACNACNAAGGNATTGGGAACNGNNATNNAANNTCTTGGGCNNAATCCCA CNNAANCNNANNTACCGGACNTNANTAATGAAGNGGATGCNNATGGTAATGGCACNATT

GACTTCCCGGAATTTCTGACCNTGATGGCAAGAAAAATGAAAGATACCGACACGTGAAGA

AGAAATTATGAGANGCATTCCGTGTGTTTGATAAANATGGTNATGNGCTATATTAGTGCA GCACANCTTTNCCATGTGATGACAAACCTTGTNGANATGTTANCNNATGACCAGGNTNAT

GANNTGATCNGGGGACCAGANATNNNNGGTGANGGGNACNTCTACTATGGATACNTGCC ACATGATGACANCNNAATGAAAACANTNTACACAATGTGGTAAATNTCTTGTANCACNAT

TGNACNTTTGCCTTTTCTTTTGTTGNGTAACTCATCTTGTAANAANGTGTNCCCCTTACTGC CAAAAAAAAAAATATCCCTGTNTTAGTANATTAAGGACTTCCTTTCCTTCCATGGTGTCTT NCCCNTATTNTTACTGGC(^TTTGTCCTGGAAACCTTTNTTTTTAAAAAAATTG GTAACATGGTTGCATTGGGGGCTTAACTCTGGGANAATATTNTAAANCCCCTTCTTGCCCC TCTTAAACTTTAAAANGGAGGGNGGNTCAAANNGAAGGGAACCAACNGGGGGGNANTCC (^TNTTTTTTTTTTTTTTTGAANNN^

NAAAAANGNN

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAAGACAAACCCACACGTCCCGGTGGTGGAAACACCCCATGA GGGCGCATCCTCTTCTCCTGGTTAGTATTTATTTCAGCACCTGGTTAATGCGGTTTTTTATT CTCTACCTATTGCACTGTTGTGACTTGTTGGCCATTATTTGATTTTTGTACGAAAAAAAAGC TTTGTTATAGAAATCAGCATACTATTTTTTTAAACCTGGAGAGAAGATATTATGGTGACTG

AAAATATGGTCAGGTGTCAAATATAAATGTATAAAAGCCTTCTTACTGGCCTGNCTGNCAT GGTACATTTATTTTATATTTGCTGGCAATACTGAAGGGTTCTTTTTCGTTTGGGNA AATTTCTATCACGGNGNCATGAATTTTTAAAATCAGTATTTCATTACAGGTGNCTCAACAT TGGGNAACTAANTTTTGCCAGGACCATTATTGATCAAGCAAATAAATTCAACAGCCATTTT GANGGAAGAAAAAAAAAAAAAAAAACTNGNGGGGGGGCCCGGACCCCAATTNCCCCTAT

AGGGNGGGGGNATNAANNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNN^ NNNNNTSπSlNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNM TSTNNN^ NNNNNNTsπsπSπSlNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

TTNAAAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGACGATTCNCTNTTTCGGNNNGTGGNTGNNGNCANGNTTNTG

GANCAGGCCTTCTCCGNCNTGGACGAGACACGGACCGCCTACATNCTCCAGGCGGTGGAG AGTGCCTGGGAAGGGGTGGACCGGAAGAAAGCCACGCGTGCCAGAGACTCAGCCACGGC CGAGAACCCTAACGGGGTTGGGGCGGAGGCAGAGGTGCTCANNCGGCCGTCCTCACTCCC CCAAGGAGGAAGGAGTGCCTGGGGCAGCCGCAGCCCCGGNCCCAATTGTGTTCTGTGTGN AGCTGAANTCACTCATNTCCCANGTGANGGACCTGCTGCCGACCTNGGCGAGGGCTTNAT

CCTGGCTTGCCTGGAGCACTACAGCTACAANCCCGAGCAGGTGATCAACAACTTCCTGGA AGGCGGNTTGGCCCCCACCCTNANCCAACTGGACCGNGGCTTGGACAGACAGGTGAAGCC GGACCCGACπsrCCCTTGNTGACGTTTNGTCACAACGTTTTCAAAAATGACAAGTTTGATGTN TTCAACANGGACTTGGTGGAACCTGACCCGGGTTGCCCCAAGGGCAGGAAGGAAGGAAA AAAAACCCCCCGGAACCTTTGTTNAACNAAAAAGCCGGGAAGGGGCCAGGCCCCACNGG

CAANNCTTTTTAACCANTACAANαsrNTGGTGGGTNGGAAGGAAGGTNCCCCTTTCAACCC CGGGGGAAGGGCTTTNCCCπSfTACCCGGGGGGGGACCAANTTTCN INGGGTTTAGNTNCCN AαsπsrCCCCCTTTCCCATTGGGGNACCCCGGGGGGGGCCNCCCAACCAATTCCCGGAACTT TGNANTTAAAAAANANTTTNTTTANNNCN^ GGCCCNAAAAAACCCAAAAATTNCCCCGNGGNAAANGGCT

TTNAAAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATΓCGGCACGAGGACGATTCNCTNTTTCGGNNNGTGGNTGNNGNCANGNTTNTG GANCAGGCCTTCTCCGNCNTGGACGAGACACGGACCGCCTACATNCTCCAGGCGGTGGAG

AGTGCCTGGGAAGGGGTGGACCGGAAGAAAGCCACGCGTGCCAGAGACTCAGCCACGGC

CGAGAACCCTAACGGGGTTGGGGCGGAGGCAGAGGTGCTCANNCGGCCGTCCTCACTCCC CCAAGGAGGAAGGAGTGCCTGGGGCAGCCGCAGCCCCGGNCCCAATTGTGTTCTGTGTGN AGCTGAANTCACTCATNTCCCANGTGANGGACCTGCTGCCGACCTNGGCGAGGGCTTNAT CCTGGCTTGCCTGGAGCACTACAGCTACAANCCCGAGCAGGTGATCAACAACTTCCTGGA

AGGCGGNTTGGCCCCCACCCTNANCCAACTGGACCGNGGCTTGGACAGACAGGTGAAGCC GGACCCGACNCCCTTGNTGACGTTTNGTCACAACGTTTTCAAAAATGACAAGTTTGATGTN TTCAACANGGACTTGGTGGAACCTGACCCGGGTTGCCCCAAGGGCAGGAAGGAAGGAAA AAAAACCCCCCGGAACCTTTGTTNAACNAAAAAGCCGGGAAGGGGCCAGGCCCCACNGG CAANNCTTTTTAACCANTACAANCNNTGGTGGGTNGGAAGGAAGGTNCCCCTTTCAACCC

CGGGGGAAGGGCTTTNCCCNTACCCGGGGGGGGACCAANTTTCNNNGGGTTTAGNTNCCN ACNNCCCCCTTTCCCATTGGGGNACCCCGGGGGGGGCCNCCCAACCAATTCCCGGAACTT TGNANTTAAAAAANANTTTNTTTANrW^ GGCCCNAAAAAACCCAAAAATTNCCCCGNGGNAAANGGCT TNNNNCAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGTTCAGGGAGCTGTTTCCCGTATGTATCCTTCAGGGACCTGTGCATATATTCAA AGGGGAACTGTTTTTGCTGAAAACTGCATTTTAACTGCATTCAGTATATGTCAAAAGAAGG

CGAATCTATTGAGAGCACAGTGAATTTGAAGGATCTGGAGGAAAAGAAGGAAACCTTTGA ATTCTCTTCTGGAATTTAAGCTATACTTCATCACTTAGATGTAAACCATTAGAGCCCAGGG AAATGCCTGCTACTGGTTGAGTGCAGAACTCCTTAGCAGAGACTGGCCCAGCTGCCTGGC ACCTTGATAGCAAAAGTTGCAATTCCCTCTGTATATTTTTCCCTAACTTGTTCCAAGTCCTC CCCTGCAGGACTTCAGAGAAGTCAATTTTCCTGTTTCCATTGTTTCTAAGAACTTGTTGCCT

AACTCAAGGTCACAGCATTTTTCTCACTTTTGTCCTATGCTTTCTTTTAGGCATTGTAGAGT TTTAGATTTΓACATGGAAATCTAGAACTTATTTTAGATTAATTTCTAAGTGATATATGGAT GTATGGAAAGTTTTCTGGTTTGNTTTTTGCTTGNG GCTGAAAAAGACTATTCTTCCTTTCCTACANTGGNCTTTGCCCTGGGTGGCNACAATTATT CCTTACCTGCCCTGGGTCTATTTTCCGGGGATTTTCCNATTTCCTTTCCCTTTNAAT^

NAATAAATNCTTGGGGCTTACCAACATTCNCCCATGGAAAANTTTTNGNAAATCCTAANG GGGNCCTTTTAAAAAAAAACNTTNGGGAAATCNCCANGGGGAAAAAANNNAAATTCCAT TGGGGGGGGGCCHTTTTTTTAAAAAAGGNGGTTTN

AANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGTGACCGGCAAGACCTCACCCTGGAGGTGGAGCCCAGTGACACCATCGAGAACGTCA AGGCCAAGATCCAAGACAAAGAGGGCATCCCCCCAGACCAGCAGAGGCTGATCTTTGCCG GGAAACAGCTGGAAGATGGCCGCACCCTGTCTGACTACAACATCCAGAAGGAGTCCACTC TGCACCTGGTCCTNCGCCTNAGNGGNGGGATGCAAATCTTNGNGANGACCTTGACCGGCA

AGACCATCACCCTGGAGGTGGAGCCCAGTGACACCATCGAGAACGTCAAGGCCAAGATCC AAGACNNNGAGGGCATCCCCCCAGACCAGCAGAGGCTGATCTTTGCCGGGAAACAGCTG GAAGATGGGCGCACCCTGTCTGACTACAACATCCAAGAAAGAGTCCACTCTGCACNTGGT CCTNCGCCTAAGAGGNGGGATGCAAATCTTNGNGAANACCTTGACCGGCAAGACCATACC CTGNANGTGGAGCCCAGTGACACCATCGAGAACGTCAAGGCCAAANATCCAAGACNNGA

GAGGGCATCCCCCCAGACCAGCAAGAGGCTGATCTTTGCCGGGGAAACAGCTTGGAAAG ATGGGCCGCACCCCTGTTTTGACTACAACNTCCAGAAAGAGTTCNACTCTGCACCTTGGTC CTTCCGGCCTTAANNGGNGGANTGCAAATTTTNCNGGAAAANCTTGGACCGGGNAANAAC CATTACCCTNGATGTTNGANCCCANTGGCANCCTTTNNGAAACGTTAGGGCCAAGAATCC

NANTGGAANATGGGCCCNCCCTTTTTGATTTNAACATCCAAAAGAANCCCCTNTTNNCTTT GGTCCTTGGC^TTAANGGGAGGGGGTTNAANTTCTCCCTTTAANNTTTNNAAN

GGCCGNTGTNNNNNTCNTTTNTTNNTNNATNNANTNNNNNNTNCCCCCNCNCGNTCGGC

TGCACTCNGNNTGCCCNNNNr>INCCCCCTNGGGGNGANN^

GCCCCNATAGTGGGGTCCTATTACCAANGGATTACANTNT(^ACNCGCNGGTTNNTCCCC GTCCCGTCTGNCNNANTNCNCMSINNTNαSfTNCNNNTTCNNNACCCNNαSfCCCCNNAGTNC COWAACGCGCGGGGGTCCTNCCGACCCAGNCNNTTNNCTGCCNCNCCACNNGNCCACNA GNCCCGNNTCNNCTCCGTNTCTNNCCCTNCCCNNNNGCNGNGCCCCCCNNNCNCCCCCNN

CNCNATACANCCACNGGNCCNNNNNNNT WCNCNGNNCTCTTCGNCGC I NCNCCGGGG ACNCTNNNGCNGNCNCOSfNCCCCATTCCTNNGNGCα^CTNGGCCCGNNCCNTCCCTACCC CTNGNGCGCGNNCGNOSINNCNNCACTCNCTTNATCNTGNCNCNTCGNCTCANCNCNTTCT CCNCNTTGCCNCCCCCGTCCGNCNNTCNNGCC WTNNCNCCCTGNGCNCNNCNNTCGTGN NTCC⁽^CCCTTN1SINCCCNCTNTCNC^^

CCCCNANNCCCN<^GNGCTNCC^TCANTTCNNTα lNNCCMfCCCTAGANCNTCCANCCCC CTNTCMNTATNCTCGC(-^CTCNTTCTCCACTCTCCCTCGTαSfTNCCCTNCCCCNTCNTNACC NCMNCCGCCCNCGTNTCACCCTTGCNNCCNCGTTGTCCCGCCGCACNCCCCCGNNACGNC TNGNNCNOSINTNTCTTNCGCCGTCCCGα^CAGNCAGNTGCCCTNNCNCCNCGAGCGGANC NNNNANCCTCCTNGNNTCNNCCGCCTGTCTCNTGTCCNNCaSTCCCNCGNNCCNCNGGαsINC

CCCT(^TC(^C^CNNCGNCNTNCCNTNTNNNCTCCGCGGTCCTCCαsrCCTNGCCCCN^ CNTCCNGCCCTCNTTNNCCNG(^TCCCATGTCTTCNCCNTNNCC(-^CCCNTNATCCNCGTG CTNTαSTCNNGNGANCGC^CTαsrNTNACTGATCCNNGCGTANCCTGTαsrGNTTCTNNCNCC CCCCNCCNNNCGTNCCCG(_^TCAGTNGC<-^TCNTNCCTCCCCCNATαsrC^CCTCTCNGCTC CCTCTCTCNCCTCCCTNCGACC^CNTCTM^CNTACACNGCGGCTTNCNNCGNNTGTNCCNC NCWOWCNTANCCCCCONπ INT>^

CNNTACCCTCGTCCNNCACCTNNCCNGCTGCNTCGTCCNCCTCCNTGGCTCNTCGNCTNNA CCTC(^GCACGTCCG(^CCNCCCGTGGNCTCTTCNCGANCCNCGCNCNNCNCNCGAATNC GG(^(^CACGαSlNCNGACGCGATGNCAGGTANGTNGCNCCNTCCGCNCGNANNTCCCNC

NCGATCGNCNCα^CGNNCNNNNATGCGACGNCCCCTCCCCGANGTCNCGNNCGCTNCNG ACGTGNCNCNCCCCTGNACGTAGCGNCCTNACCCTNTCTTTCTCCCCCNCNAGGGTCCCGC CNCTCCCGCCCCCGCTNCNNCATCGGTGCTCCNTCCG

CTCGACAAGNGGGNGGGAAGNGNCTGCNGTGCTCTCTTTNANCAANATCTGGAGCTCCAC CGCGGTGGCGGCCGCTCTAGCAACTAGTGNGATGCCCCCGNGACTGCAGGNNTCCGGCAA TANGNTCNTTTTNGATTNNTNTAGGANTACATNNGCATATNCTTNGGGGGTCATTTCANGG

TNCNNNNNC(^TNTTNAANCCGAGNNANTNNTANNTTNNG NNATNGAN(^TGANGGATANNTNNNANGNNTNTTTAATGGTNCANANGNGCTNTGNTNN

ANNTNAGNNNC1TNNNNGGGNNNAACGNNNGNTNNAGNANNNTANNN MNCNGGTN^ AGNNNGACCCGNC^AATTGTTTGNTTN(^TTCCCGNGGANTCCCANTT(^AGATTTGNGG NNNNANGCNTGGNNCGGNGANNTT WTTNANNNTANAATNNGNCNO ^^ CTNTNGNCNNTTNGNGTANNANNNCTTNAGNGTNNTNNTATNTNNTCNANNT^ CGNGNNCAGNNTNNTNCNTNANTGANTNTNGNNCAGNAGGTCGGTTATNTNCTTNTANNA

TACNNTNNTTTNTCCNGCNTC3SΓACNNTATNNATTGNAAATNTCNT( CNTGAANN^ CANNNANCTNTNNCTTTTNTGNCα STGCANANAAGCGTCCCNTTTNNπ TCNNNGTTNTNACTGNCCTGGCNCTTNNT^ (^CTCNNNGTNTNTGCTACNNNTCACCCAACANAGCCCCCATANCACANTAGNCTCNCNN ATTCCNNCANNANNAAGTTNCNTNATCNTTNNNAATATTAATTNCGCTTNCCGTTπ

NCNNTTNATCTAATNATTTGTTTANTGTGACAGNTTCCAANGNACCTNGANCNNCTTTTNA NNGNACTCGCCGGNTGGNTAGGATCGTNAAGTCTNTNTNNNCTGCCNGTNGTNNNCNNCT NATGTANANCATTOS1NGNNTNCAGCNGTATNTNCTCTTNTACCAGCNNANGAGTNCNNAT CAANANNTATNNNNNOSfTGCCTGNTNCCATTCNAGGGTGCTTTNTGTNAANNNCNTGCCN TNGANATGNATATNTTTTGAACTNGTGANANGTTGNNACNNAATNGAC(_^TATGTNNNTG

TAGTGCTCTNGCTTNGGTNTCTNCNNATANTAC^^ TNGTNCGTNGCGNTNNNCNNGCGNCCG

NAAAACTGGAGCTCCACCGCGGTGG^'CGGCCGCTCTAGAACTAGTGGATCCCCCGGCTTGN

AGGCCGACGCGCTTCGGTATCTGCGGGCCCCGGTGCAGACATGGCCAAGTCCAAGAANNA CCCNAGCCCCANCCANTCCGAAAATNGNATNAGAAACCGGATTAANAAACCCCGANCNN NACNANNTNAATTTTTTAAGGGGGNNAANCCCNANTTNCTNNAGAACNTNCCCTT^^ ANAANCNCNACNAGAANGGCCTNAANAANANNCNNGCCNACNATNCCNAGGNCNTNAAT GCACNTGCTNANGCTNGCAAGGGCCTTGTGAAACCCAAGGAGANNAAGCCCAAGATNCC

ACAGGTGGCAGCCGCAAGCTTAANCGACTTGGCTANATTCTCACACCANACTGNGGAAAN GCGCTCTTGCTCTCATTCCAAAGGGCTCNANGCTCTGTCCGGCANAANCCAGGGCAAAGG TTTNCNCCAAGNNAAACCNCNTGTGGNTGTGGNTCNACTGTCAAAGGTGCCAAGGCCCCA CAAANATCTNGAGTANAAAACCTNTTTTGTCACTGTGAAGACAACAAAGACTTGTGTGAC CCCTTGTGTTCTTGTCTTCCGNGGGGCTTGTGTCCTNCTTGTGTRØTTTTACCACATAAATC

TTGTGACAGGGAAAAAAAAAAAAAAAAAAAAAAAAATTTNGGGGGGGGGNCGGGGNCC CAAATTNNNNTTITNTTTNGGGGGGGNN NNNNTSΓNNK ΠSΠSΠSΠSINMSINNNNNN^

NNNNNNNNNNNNNlSπsiNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNTSπsπ TNNNN^

NNNNNCT

NAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCTTGN AGGCCGACGCGCTTCGGTATCTGCGGGCCCCGGTGCAGACATGGCCAAGTCCAAGAANNA

CCCNAGCCCCANCCANTCCGAAAATNGNATNAGAAACCGGATTAANAAACCCCGANCNN NAC^ANNTNAATTTTTTAAGGGGGNNAANCCCNANTTNCTNNAGAACNTNCCCTTT^

ANAANCNCNA(^AGAANGGCCTNAANAANANNCNNGCOS[ACNATNCCNAGGNCNTNAAT GCACNTGCTNANGCTNGCAAGGGCCTTGTGAAACCCAAGGAGANNAAGCCCAAGATNCC ACAGGTGGCAGCCGCAAGCTTAANCGACTTGGCTANATTCTCACACCANACTGNGGAAAN GCGCTCTTGCTCTCATTCCAAAGGGCTCNANGCTCTGTCCGGCANAANCCAGGGCAAAGG TTTNCNCCAAGNNAAACCNCNTGTGGNTGTGGNTCNACTGTCAAAGGTGCCAAGGCCCCA CAAANATCTNGAGTANAAAACCTNTTTTGTCACTGTGAAGACAACAAAGACTTGTGTGAC CCCTTGTGTTCTTGTCTTCCGNGGGGCTTGTGTCCTNCTTGTGTTNTTTTACCACATAAATC

TTGTGACAGGGAAAAAAAAAAAAAAAAAAAAAAAAATTTNGGGGGGGGGNCGGGGNCC CAAATTNNNNTTTTNTTTNGGGGGGGNNTTTTAANNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNCT '

AAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGCGGTGACGGCCGAGGCGACAGAACCGAGGGGCTGTCGTTG

GTGGGCGCTCCAGGGCTCTGAACGAGAGAAGCGTGACCCGGAAACGGAAGCGAGTCCCC ATCCCAACTCCGCCAGGTTTCACGCTAGCCCCAGGCTTACTGGTAGGCTCCTGCTGCCATG GACCTGTTGTTTGGGCGGCGCAAGACGCCAGAGGAGCTGCTGCGGCAGAACCAGCGCGCC CTGAACCGGGCCATGCGAGAGCTGGACCGTGAGCGACAGAAGCTCGAGACCCAGGAGAA GAAAATCATCGCGGACATCAAGAAAATGGCCAAGCAGGGCCAGATGGACGCGGTCCGGA

TCATGGCGAAAGACCTGGTGCGCACCAAGCGGTACGTNCGAAAGTTTGTGTTGATGCCGG CCAACATNCANGCTGNGTCCCTTCAAGATCCANACACTCAAGTCTAAACAACTCAATGGC NCAAGCCATGAAGGGCGTCACCAAAGCCATGGGCACCATGAACAGACAGNTGAAGTTGC CCCANATCCANAAGATCATGATGGAATTTTGAGCGGCAGGCAAAAATCATGGGNNTTGAA GGAGGAAATGATGAACCAACCCCCTTCATTAACCCCNTTGGGGGACCAGGNCCATTAAAA

AGGGAAAGTGNTGCTTTTTGTAACCCCAGGTNCTTGGACNAACTTGGGGGTTGANCCTGA AAAAATGAACTTTTAAAAACTTTCCTTTTCACCGGANGGTTTCCTTTAACGNNGGNT^ CGNGGNAAAAAAAACCAAAGGGTTTCACCCTTTTGNCCTTGNGGGANCCCNAANCCCNAA CCTTGGGNGGGNAAGGTTTANNAAAOSINTTTNAANGG CAAGG

TTNANAAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCATCAGCAGCTCAGGCCCTGCTGNGACCTACCGACCCTACGACGAGGGTCTGAG GCGGNGGGTCTTCATCACCAATGAGACTGGGCAGCCACTGATTGGGCAGGTGTGGCCCGG

ACTCACCGCCTTCCCCGACTTCACCAACCCCGAAACTCTTGACTGGTGGCAGGACATGGTG ACCGAGTTCCACGCCCAAGTGCCCTTCGATGGCATGTGGATCGATATGAACGAGCCATCC AATTTCGTGAGAGGCTCAGTGGATGGCTGCCCGGACAACAGCCTGGAGAACCCGCCCTAC CTGCCAGGGGTGGTTGGCGGGGACCCTCCGGCAGCCACCATCTGTGCCTCCAGCCACCAG TTCCTGTCCACGCATTATGACCTGCACAACCTGTATGGCCTGACTGAANCCTTACCCTCCA

CAGGGCCTTGGTGAAGGTTCGAGGGATGCGTCOSITTCGTGATCTNTCGCTNAACCTTTGNT GGCCACGGCCGATACTCCGGCCANTGAACAGGGGATGTGTGGACAACTGGAACANNTTTC TTACTCCGNGCCAAAAATCCTGNTTTTAATTTGTTGGGGGTGCCCCTGGGAAGGGGCTGAC ATTTGGGGNTTCTTGGCAACACTTNAAAAGAACCTGNGTTGCTTTGAACCAANTTGGGGG GCCTTTTTACCCCTTTTTTGGCGGAAACCAAATTGCCCNTGAAAAAGCCANCCCGAAGGN

AACCCGTANAAGGTTTAANNGAANACGGGNNCAACNAAGCCTTGAAGGAAAGGGCNTTT AACCCTTGGGGTTNAGGGGTTAATGGGCCTTATTTTTAAACCCCTTTTTCCCAAGGGGNCC CCαSfTTTAAAAAGGGNAAAAAAAGGGGGCCCGGNCCCCTTTTTTTTGGGANT

TTGANAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCATCAGCAGCTCAGGCNCTGCTGGGACCTACCGACCCTACGACGAGGGTNTG AGGCGGGGGGTCTTCATCACCAATGAGACTGGGCAGCCACTGATTGGGCAGGTGTGGCCC GGACTCACCGCCTTCCCCGACTTCACCAACCCCGAAACTCTTGACTGGTGGCAGGACATG GTGACCGAGTTCCACGCCCAAGTGCCCTTCGATGGCATGTGGATCGATATGAACGAGCCA

TCCAATTTCGTGAGAGGCTCAGTGGATGGCTGCCCGGACAACAGCCTGGAGAACCCGCCC TACCTGCCAGGGGTGGTTGGCGGGACCCTCCGGGCAGCCACCATCTGTGCCTCCAGCCAC CAGTTCCTGTCCACGCATTATGACCTGCACAACCTGTATGGCCTGACTGAAGCCTTAGCCT CCCACAGGGCCCTGGTGAAAGCTCNAGGGATGCGTCCCTTCGTGATCTCTNGCTCAACCTT TTGCTTGGNCACGGGCGATACTTCCGGCCACTTGGACAAGGGGAATGTGTGGAGCAACTG GGGANCCAGCTTTTCCTACTCCCGTGCCANAAAATCCTGCTTTTTAAATCTTGCTGGGGGT GCCCCNTTGGTAAGGGGGCTGACATNNTGGGGCTTNCTGGGCAACACCCTNAAAGAACCT GTGTGTTCNTTTGGACCCCANCTNGGGGGCCCTTCTACCCCCTTCATTGCCGGAACCCCAA ATGCCCTTNAAANAGCCCAGCCGGAAGGAAACCGTACAAGGTTTNAAANGNAAAANGGG

NCCANAAANGCCATTTNNGNAAGGGCCTTTAAACNTTGGGNCTTANGGGNCATTGGGCCT ANTTTTTTACAAANTTGTTTCCCAANGGNCCCCCNTTTAAANGAGGAAAAAAGGGGCCCN CCCCCCNNTTTTTTGTGGGTACCCCCCT

TNNNACAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGCCGAACTGACCCAGAGAAGGGCAGTGTCGTCTCGGCGGCGCTGCAGAAACCCC CACCCAAGACGGCTCCCCCTCCCCGGGCCTGTCCCCTCTTGCCCGCGAGTCCTCTCGCCTC GTAGGCCTCTCGGATCGTATATCGTGGGGTGAGGTGAGAGCAGGCCCGGGGAGGGTGGTT ACCGCTGAGGAGCTGCAGTCGCAATCAAGATGATAGAGGTACTGACAACAACTGACTCTC

AGAAACTGCTACACCAGCTGAATGCCCTGTTGGAACAGGAGTTGAGATGTCAGCCAAAGG TCTGCGGCTTGAGACTAATTGAATCTGCACATGATAATGGCCTTAGAATGACTGCAAGACT GAGGGACTTTGAAGTACAAAGATCTTCTTACTCTAACTCAGTTCTTTGGCTTTGACACGGA GACATTTTCTCTAGCTGTGAATTTACTGGACAGATTCCTGTCTAAAATGAAGGTACAGCCC AAGCACCTTTGGGTGTGTTGGACTAAGCTGCTTCTATCTGGCTGTAAAATCAACAGAAGA

GGAAAGGAATGTCCCATTGGCAACTGACTTGATCCGAATAAGCCAGTACAAGGTTCACGG TTTCAANACTTGATGAANAATGGAAAAANATTGTATTTGGAAAAAGGTGTGTTGGAAAAG TCAAAAGCTTACTACTGGCTITTAAGTTTTTTACAGGCTNTTATTACTCACTTCCCTT^ AAAAAACGTGCCCCCANTGNAAAGGGAAAAAGTNNCCTTTAATTTTTTGAAAANACTTAA AAACCCCAAOSfTTTAANGGGCATTGCTTACTGGGANGGAAATAATNNTTTTTTTT^

(^AAAGCCCCNTTTNGGGGNGGGGCNTTNGGCNANTNANCC

GAGCCTATANNGAGNCGNATTACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGTCCGGCAGCTCCGGAGGCTTTTTGCCCAGCTGGCTGGAGATGACATGGAGGNCA

NCGCCACAGAACTCATGAACATTCTCAACAAAGTGGTGACCCGACATCCTGATCTGAANA CTGATGGCTTTGGCATTGACACATGTCNCAGCATGGTGGCTGNAATGGATAGGGACACGA CTGGCAAACTGGGCTTCGAAGAATTCAAGTACTTGTAGGAACAACATCAAANAGTGGCAG GCCGTATACAAACAGTTTGATGTTGACCGNTNAGGGACCATNGGNATGCATGTGAACTCC CCAANGGNGCCTTTTGAGGCAGCAGGATTCCCGCCTGAATGAACATCTCTACAACATGAT

CAT(^CGACGCTACTCANATGANGGGAGGGAACATGGATTTTGACAAATATCATCNAGCT GCCTNGGTCANACTGGNATGCCATGNCCCCNTNCCTTCNANTCTCTCGACAAAAGANTGG CACCTGGACAAATCCAGGTGANCTCCNTNGAGTGGCTNNAANCTNGNCATGNTACTCCNT GAAACNNGGAGCCCCAANGNCCTGCCCCNCTCATTNCCTTTGCTGGNNGGAGTCCNCCCT TNGACTTCTTCGGNCCCCCCCCANGGCNTNATTTCTTGNNTGCAAGTNACAATCTCTCNNA

GGGGTCNCTGCCNNACCCCCTTTTTNGNCTNTTT^

NTCTACCANCAOSINGGNCCCAANCNTGGNCTTTTNNCACTGCCNTGNCCCCTNNAANTNC CNCNCCCTCNACGCACAANCCCATTCTTGNTTTANCTTCCANNAACCCTTATATTTGCACC CNGTTGNCANNCCTCCACAANCTCGNNGTGGTTTTCTNCCCCNCCCAGGGGCCNCTNNTN (^TAACTTCTNTGNAAGGAATAATNNCTNNNCCOSfTTGTNNCTAAGGCNCNTNCTT^

CTTTCCACTCTCCNNTCTC fNTNCATCTNTGCCCANATATNTTGTGCCCTTNCN

CCCCCCNNπOSINNNGNAGANGTNTNNN

CNNTCNNTNCCTNGNGGGAGGNNNC^INNC

ANAN πSINNN S(NTTNNGGNCTTATATGAGTCGTATTACAAANGNATNACACTCCCNCCCMN GNGGCTCTNCrø [ANACACGGCCGNNANT(^<^TC^CNNNATTTTATTTTNNCN ANTNNTNCCTNCCC^CTCGATGGNGGGC(^TC(^TCGCNNTNGTCNCTATNNTmCTTTCT

NTNNNACANTCACCCTNGCTNCCCCGNCTNACGANTNGAGAGNTCTACCNNNCNNGNNA

NN<^TCNNANNGATCCOSrCCTGCCTNNNTNGNNCCAGTCNCACNCTANTCNNTNCCGGCN

TCC<^TTTNCTCTCNNNNNNCNCCN^

GNTOANAN⁽XX2*TNNTNANNNTC^^ NNCTCTTTAGAGNCGACTCCCANNCNNNGN<^TTTGNANNTCNCNNCCCΑWGNTGATNT

ANTWCTNTTNNCTNNNCNCCGNCCCCTANNTACNOSΓNTACGANTCGNNNANNAANNCTCN

NACTCGNCGANNCGTCNGTNTANTNNNCNGNCNCσsrCNAαsπsfTTNNGNNCCαsrGACTTCAC

GTNTACGAGANNNOSINGCCTNNTTGANTC<^^ NNGACCG(_^GCTNANCCCNCTANGANCNCCNNGAGNCCNTGNCTNCGTNTCGCNCTTCCN

TNNNNNANMSπSfNTGTNGTGCNA(^ANTGANTCCCαSfNTNOSINCCATCN^

TNCNTO^CC CTNNC(^G

NTTNCCNTCGANTCCACTNNNNNGTOSπSINANTANNCCNNNNCTGTNNACN^

CCTATNTGTCCTTOSINCTACTNNCAGCNCTGCTNNTC(^CNNTCATGCTCCACCACGNNCN NCTNr^NNAGTGTGNCTNCNCCNCCATCNCC^^

TCTCCNCANGGATNCCCGGTNACGNCNNCGNNNCAGCT(^TNT(^CTTCGNATTNCTCNG

NNCCCCCCTANCNTNNCTNACTTCACTCCTCTGTCCCTATTGCCCTNNATATNCNCCACGG

NNGGANNNTNGNCNTCACGNCCGNCCGOSINTATTNCCTCTGTCNCNTCGGCACNNGANNN

TACGCATCCNGCNACCTCCNATGATCACTNNGNTCTGTCGNNCCCCCGCANGCGTNTCGC NACGTNTCGNTATNTCTGCGTTAGTCGCNNT(^CCCTGGNTTNCTCCACTCTGTAAAGNCA

CGCTCN<^GTTNNNGTGCTCCGTATCTTN^

CCANGCGNCGATTGNGTGTTGNGCTNNCGAGNTAGNCGCCNCCCNCNCTCACCNTNANNG

ANNNNCNCCCNCCCCCCCNCACG

GCCCTATANNGAGNNGTATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGCCGCTCCCGAGCGCGGCGGCCTCGTCTCTAGGCCGTGCAGC TGCTGCCACCGCCGTCTGTCTGCCTGCCCTCCCGTCGGTCCACCCGCAGCATGAGCGGCCT GCGCGTCTACAGCACGTCGGTCACCGGCTCCCGCGAAATCAAGTCCCANCAGANTGAGGN GACCCGNATNCTGGATGGGAAGCGCATTCANTACCANCTAGTGGACATTTNCCAAGANAA

CGCCCTNNGGGANGAAANGCNANCCTTGGCCGGCAACCCCAAGGNCNCCCCACCCCAAA NTGNCAACGGGGACCANNATTGGGGGGACTATNAACTNTTCGTGGAGGNTGNGGAACAA AACACACTGGAGGANTTCCTGAAACTGGNCTGAACCAANTCANCCCCCTGGACTTTGTCA TTACATTTCCCTTCCCAGGCATTACCCCGGGCATNAAGGACCTTGTGACCAACTTNCCTGT GTATTCCTAACCTGAACGGGGGGNGCTCTCCCCTCAANCCAAAGANCCCTTTTCNTCCCCT

AANTGTAAGCCCCCTTCTTTTITATTTAGAAAGNAANATTTNCTCNCCCACCGGGGCTCAN AAAATTGTGNTTANACAAACANACCNAAATGGCTGGNNTGTTNCTCANANTCGGGNCCCT GNGGGTTGTCACCCTTGNCTGGGNCTTGTGTGATGGGGCACCTTTTNTTGATNTCCATTTA TACAAAGGNTTTNTNAAAAGGGCCCNCAATACCCCTTNCGGGGNGCACCCCCAGAAAAA AATNAAANGGTTGCCNTTTNCATTGNGANAAAAAAAAAAAAAAAAAACTNNGGGGGGGG

GGGGGGGCCCAAACTTNNTSfNTNNTTNTTTTTTNGNGGGCTNTAAATN^

GGNGGGNGGGGNGCGNAAGGAAATNTT ATTT]SNN^ TTAGTOSITAGNGNNGNCANNTTNTNTTTTCNTCNGGGANNCCTANTAGGAACTCCCCCCN

TTTGAGNCNCNNTGGAGNNGCATTACAGGGGNGGACGCTCTNCAANTAGTGGCTCCCCTC CGTTCTTGNTACGACTNNNCCCCNCNAANNGTC^ N(^TCCNNNGGGGGNTTNTNTNTTTTCTCCCCTCANTNTTATCNTTTTNCNN^ GTTTTCCCGATTNATTTTTTCC TNN^ TNTTNTCNACNTCNTATTCNTNTACCAGNOSFCNTTNNTTTNNNTΠ

CTAATNNNCNNANATTNNNTCTCGTTGNTGTGCCTNCTCTNNCNTCTTNCTTT^ ANCNNNTNTCNTNTCCNCGTGCCTGTGAGTTANCNOS[NCNANCNGNGTNTTTATANCNTN TGTGNCTNTTACTNNACGANNTGTTNNCTNNGTNNTSΠSFTTTNTT^ TCTTTCGNGANNTNTNNNTNNTCTCTNTNGGTTAATGAANCTTNNTCTGNNTCTC TCTOSΓANNTTCNNNANNTGTCCGATGNGNNTNTATNCGTNTATCTCNNNGCNTNNCNAN

NNNCNATGTTCTANNAATNTTTNNNNNGTNATGNNOSINNT^ TGGTTTANNTTTTCTNTNTNNTNNATCGTNNTNNCGTGTT(^ TGATANNNTCNNNGTTNTTTCGNTTCGNNNTCTCTCATGNTTNCCCATNANGCAG(^TΑSFT GTCATNTNΣSTCTNGTCNC^TNTTNGNTCTA<^GCACNGNTTANCANN(^TANTTCCTCCTA CTCGCTCC<-^TNTNTNTCNNTTT™^

TNTATNTNATTANGNTNNTNGTNTTANTNNCTCT(^CNTNNNGAGACNCTCTATGTGGCNT TCNTGTAATNCTCCCNTTNATATANTATNTNNTANGACACTNTCTCTNCTCNNTNTATCTA NNTCTAACTNTCGNTCGTCGTT JNNTCNTGANNNCCTANGTANANNCNCGTTGTNCGNGN CGCTNTAANGNTNTNNTCTTCTAGNNCGGCTNNCTCTCTNACGTACNTTTGTAANANTANT NANTNNATGGAGTATTCTCCTTNTCTAGATCGATC(^CCGTACGTNNNTAGCTATNTTCTG

TANCACNTAANGATGTCTTNNCGCTNGTGTNNGNNNTTNGTNTNTNANGTGTGTNTNT^

(^TNTGAGTGTACATANGTATGTTCAATCTNTNTTTCGTACNGTATGNNACTTNCGTGAAN

NNCTCNACGANACNTANNTACGGACAANGTNNCNNANGTANCTNTNNGTACTTACTNTTC GNANTGNTACGGTCCCTATCTATGNATGTNTNTTGCGTCGTGTNTNGTTNCTATATNTCGN NTNGGTAGNGGCCG

GGNGGGNGGGGNGCGNAAGGAAATNTTTTATTTNNNNTTNTNNNT^ TTAGTCNTAGNGNNGNCANNTTNTNTTTTCNTCNGGGANNCCTANTAGGAACTCCCCCCN

TTTGAGNCNCNNTGGAGNNGCATTACAGGGGNGGACGCTCTNCAANTAGTGGCTCCCCTC CGTTCTTGNTACGACTNNNCCC(^C^AANNGTTGTTTTTNTNCTCσsrTCT^^ NOSfTCCNNNGGGGGNTTNTNTNTTTTCTCCCCTCANTNTTATCNTTTTNCNN^ GTT CCCGATTNATTTTTCC(^ATr^ TNTTNTCN AOSfT(-^TATTCNTNTACCAGNCNCNTTNNTTTNNNTTTTNT^^

CTAATNNNOWANATTNNNTCTCG GNT

ANCNNNTNTCNTNTCCNCGTGCCTGTGAGTTANCNCNNCNANσSfGNGTNTTTATANCNTN TGTGNCTNTTACTNNACGANNTGTTNNCTNNGTNNNNTTTNTTT^ TCTTTCGNGANNTNTNNNTNNTCTCTNTNGGTTAATGAANCTTNNTCTGNNTCTCGT^ NTCTCNANNTTCNNNANNTGTCCGATGNGNNTNTATNCGTNTATCTCNNNGCNTNNCNAN

NNNCNATGTTCTANNAATNTTTNNNNNGTNATGNNCNNNTNCGNNAGNNNTNGGNN TGGTTTANNTTTTCTNTNTNNTNNATCGTNNTNNCGTGTTCNATCCT^ TGATANNNTCNNNGTTNTTTCGNTTCGNNNTCTCTCATGNTTNCCCATNANGCAGCNTCNT GTCATNTNCWCTNGTCNOSITNTTNGNTCTACNGCACNGNTTANCANNCNTANTTCCTCCTA CTCGCTCCCNTNTNTNTCNNTTTTNC^^

TNTATNTNATTANGNTNNTNGTNTTANTNNCTCTCNCNTNNNGAGACNCTCTATGTGGCNT TC^TGTAATNCTCCCNTTNATATANTATNTNNTANGACACTNTCTCTNCTCNNTNTATCTA NNTCTAACTNTCGNTCGTCGTTNNNTCNTGANNNCCTANGTANANNCNCGTTGTNCGNGN CGCTNTAANGNTNTNNTCTTCTAGNNCGGCTNNCTCTCTNACGTACNTTTGTAANANTANT NANTNNATGGAGTATTCTCCTTNTCTAGATCGATCCNCCGTACGTNNNTAGCTATNTTCTG

TANCACNTAANGATGTCTTNNCGCTNGTGTNNGNNNTTNGTNTNTNANGTGTGTNTNTNG ( NTNTGAGTGTACATANGTATGTTCAATCTNTNTTTCGTAC^GTATGNNACTTNCGTGAAN NNCTCNACGANACNTANNTACGGACAANGTNNCWNANGTANCTNTNNGTACTTACTNTTC GNANTGNTACGGTCCCTATCTATGNATGTNTNTTGCGTCGTGTNTNGTTNCTATATNTCGN NTNGGTAGNGGCCG

CANAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAGCGCTCGGAGTTTGCCACTTATCGGTCATCCTTGGTGTCCGC AGCACTCTCTCCCTCTCTCTAGGGCGGCGACCTCCGGCGGCCGGAAAGTCACCATGTCCAT

CCTGAAGGTCCACGCCAGAGAGATCTTTGACTCTCGTGGGAATCCCACCGTTGAGGTTGAT CTCTTCACCGCGAAAGGTCTCTTCAGAGCTGCTGTGCCCAGTGGCGCTTCAACTGGAATCT ATGAGGCCCTGGAGCTTCCGGGACAATGATAAGACGCGCTACATGGGGAAAGGTGTCTCA AAGGCTGTTGAGCACATCAATAAAACTATTGCGCCTGNCCTGGNTAGCAAGAAGCTGAAC GTCGTGGAGCAAGANAAGATCGACAAGCTGATGATAGAGATGGATGGCACANAAAATAA

GTNCAAGTTTGGTGCGAACGCCATNCTGGGCGTGTCCCTGGCTGTCTGCAAGGCTGGTGCT TGTGGANAAAGGGGTGNCCCTNTANCGGCACATNGNCGACTTGGCTGGCAATGCTGAAGT CATNCTGCCAGGTNCGGCTTTTAATGGCATCAACGGNGGCTTTNATGCTGGCNACCAAGC TGGGCCTTGCCGGANNTTATTAATCCTTTCTGGTGGGGGCCCAAAACNTTCCGGGAGGGC CATTCCCCATTGGAACCAAAAGGTTTANCCCCAANCTTGAAAAAAGNTCTTCAANGGANA

AATTTTGGGAAAGGATGNCCCCCCACCCTNGGAAAAAAAAGGG(^GGTTTTTNCCCCCAA CATTCCTGGGNAAAAAAAAAAAAANCCCTTGGAACTTTNTTNAAAAAAGGCCCTTTGGCA AAGGGTTGGGTTTCAAAGGNAAAANGGGCTTNATTNGGGAATGGGCσSENAAACTTGCCCT TTAA

TTNANCACNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGNCACGCANGCCCTCANCATGGAGGGAGCNCGNCCGCTGNCGGCGGCTCGC GGCAGCNTCTGAAGAGGCCAAGGCGGACGCCCCCTCTGCGCACAGTGGCTGGGGGTGCGC ACCGNCTCANGGGCTGGCCCACACCTTTCTCTGTGAGGGCGAGGGCTAAATATAACCCGG AGAGTGAAGCCAGTGATAAGCTGGGGCCTGTCTGGNCCTGANTTCTGTTGAGACCTGGCG GNTAGCAGGGCCCAAGCTAGGNCCGGCTGGGAGACGTTAGTGTCTCCTTGTGCTAAAGGC CTGGCTGACCTCACCCACAAGATCCCAGCCTCCCCACTATTTATAGCCCCAGAGGCCCTGG GAGGGTAATGTGGGGGCAAGAGGAAAAAGTGGAANGAACGTGTGCATTTGAACCTTTTG

AGTCTTGGTTATGCTGCTAAAAAACCACATGACCATGGCAAGTTGCCTTAGGCACTTCACC TTAACCTTCCTTACTTGGGCAAGTGGGGGGNGATGGNCCACATATAAATGCTTGGGGAGG NCCATTTGGANAATCACACAAGAATGCAAAGTANCAGGTGCCCGNTTTTGTTTGATTGAA CCACAGGCTTTCCAAATCCAAGCCACTTGTNAGGCCTTTGGGCCCTGAAAATTTCTTGAAA CNAACAACTTAGGTTTTTCAAGGGAAGGCTTGGNCCTGGGCCTNAAAAANNTTTTGNTπ

NAAAAANAATTCTTNGGGNCCCAAATTTTTTAAAA^

AATGNATTANGGGGCCTGGGGGGGGGGTTTTTAAAATNCAAANGGGGGGGNCNCAGNTT

TTTTTTTTTTTTN

TNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCTCGAGTTTTTTTTTTTTTTTTTTT^^ NNNNAAΛAAANTTTTTTTTTTTNNNAAA^

GGGGGNNNNNAAAAAAAAAATNNTSINNNNTTTTT^^

TTTAAAGGNTTTNNNNNANNGGGGGGGNTNNNAAAAAAAAAAANGGGGGGGNAAANNG

GTTTTTTNAAAAAAAANTTTTTTANNCCCCCNGGGGGNNAAAAAAAAAAAA

NAAAAAANGNGGGGGGGGGGGNCCCCCCCCCCC(^σSINNTTNTGGGGGGGGGGGANNN NNNANNNINNNNNNNIS^^

NNNNNNNNNNTSπSINTSINNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNTSπS^

NNNNNNNNNNIS^MlSnSINNNNNNNW

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNISπSfNTSINNNNNCCGNNNNNNCGNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNTSπSTNNNNNTSπSlNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNCNCNCCCCCCCCCCCCCT

TTNNNNAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGTTCCTGTTAACTCTTAATAAACTTACACATGCAAGCATCTACACCCCAGTGAGA ATGCCCTCTAGGTTATTAAAACTAAGAGGAGCTGGCATCAAGCACACACCCTGTAGCTCA CGACGCCTTGCTTAACCACACCCCCACGGGAAACAGCAGTGACAAAAATTAAGCCATAAA CGAAAGTTTGACTAAGTTATATTAATTAGGGTTGGTAAATCTCGTGCCAGCCACCGCGGTC

ATACGATTAACCCAAGCTAACAGGAGTACGGCGTAAAACGTGTTAAAGCACCATACCAAA TAGGGTTAAATTCTAACTAAGCTGTAAAAAGCCATGATTAAAATAAAAATAAATGACGAA AGTGACCCTACAATAGCCGACGCACTATAGCTAAGACCCAAACTGGGATTAGATACCCCA CTATGCTTAGCCCTAAACACAGATAATTACATAAACAAAATTATTCGCCAGAGTACTACTA GCAACAGCTTAAAACTCAAAGGACTTGGCGGTGCTTTATATCCTTCTAGAGGAGCCTGTTC

TATAATCGATAAACCCCGATAAACCTCACCAATTCTTGCTAATACAGTCTATATACCGGCA TCTTCAGCAAACCCTAAAAAAAAAAAAAAAAAAATTNGGGGGGGGGCCCGGNNCCCAAT TTGNCCNTATAGGGGGGGNNNNTNAANNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNHNfNNNNNNNNNNNNNNNNNN^

NNNNNNNNN NNNNNNNNNNNN

GCNTATNTGGAGCTNCACCNCNNGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGNCNNCGNCCCGNCNGGGGNTGCCGGCATNGCAAGAACNANCCGNACNCAGNGNGN NNCTTCNGT(^ATGTGNACNTGATGCTANAATTNATATNNTNGNCTNNGNGCGNANNAAG

NCNAAANCGGNTGAANCCC CTNTNTNGNNlS^^ TTGATCTNAAACCTTGTNGGCTGCGANTATTTGTACCNCCNANTANNTGNTGANGANCTG AGACNGAAAGGGNTNNCNCATACTNNTGNNGCTNCANCCGTTANATGNNATGCGNANGA NCNNGATGTNGTGTTGTGCTGNATNTNATACACTN(^CAC^GGTANNCGCrøJTGNNNTTN

GAANGNCMISINNGNNNNANGGNCMNGGNNNC^

ACCAAANNNGAGNNOSπSINGNACNTGNNANTGAATGCCTNCGACGGNCCNANNNNAANCT NCNNNGCCGACAAAAAATO^NNNTGNATCAAAANNGNNGNTTTANCAANNTNAACGCGG

ATGAANNTCNTNNCATGNCGGNATAAANGNGANNTATACCANANTGANGCNGGGNCTAA TNAATTCCTAANNATGGAANCGTGTACCAATGGCNGCCCTTCCTAATTAGCCTCAATNCTT TCCCTACTTNTGANANNCTCCANTAAAATGCTAGGNTNTTGTAAAAAAAAAAAANAAAAA NAAATTGGGNGGGGGGGGNANATTNCCAAAAANAACCTTTAAAAANGGNNNNCNNTNAA AGCAAATTTTAAANGCNCTTGNANAATTTNQNAANGGGAAANNTNTGGAAAAAANNAAA

AAGGCCCNNATTTNNNOSπsrAAAAAGGNNNTTTNN^ ANCCCAAAACCNGNNNCTTTTNNAANAANNT^NAAAAANCNCNN

NCNACTGGAGCTCCACCGCGGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGAAATTCGGCACGAGGGCTGGATGCAGAATAGGATAATCTGGAGAATGGAGGAAGAA TGCAAAACGATATAGTATCCCTTATGGATGGTACATGTGCAACAGGGAACTATTTCATATA CCCTTGGCAGTCTCTGATAATCAGGGAGGAAGAAAAACCTGGAATTTGGATTAAGGCTGA TCTTTCTGGTTTTTGCGCACTGTGGCTCTCCCAGGCATATATAGTGAAGGTGAATGTCTTCT CCCTCAGAAAAACTCAGGTTCCTTGCTGTCCTGATAAGGCATAGCTTCCCTGCCGTAACTT

AAAACTCAGTGAGGACTTAAGAGGGAAAGAATGAGGCAAATATATAGGACTGCAGGATA ACAACTGCATTGTTGTGTACTGTGGAATGGGGAGGGCACTCTTGGAGGAGGACTGCTGAA GGTGGTCAGTCTACCTGAGAATGGAAGACATACTTGGTGGGGAGCANGGTATGTGCTTTT ATATGAAAAGAGCCGATGTTAAAACTCATTTGGTTAGGTAAACGTTGCACATACCTTCAC ATAANGGATAGTATATTTTGGGTTGCAGTCAAACTTCATTGTGCTCAAACTGGTGAAAATG

CAGTTAGGCTTTTTGTAAATACCAAAAAAAATCCGGTCTCACTCTTAATTCANGNGGCTAC TGCTACTTCANAATGATTTTAAAAGTCCNCCCCCCCTCCCCCATGAANNTTCTTCCTATTTT TTATGCCTGGAACCTTGCCCCCAANNTTTTGTTTNNGGAATTTTACTTNT^ AATNANCNTTTNTAAANNTCNAGCCCCTTGNNTTTTNANANTNANNNTTTT^ NTTANNNAAAAAAAAAANNNTSTNNNNNNNNNNNAAAAACNGGN^

ANGGGNNTTTNNNNNCCANCT

TTNNNATAGNGAATNGNTANGANNCNACCNΠSΓCTNNNCCTTTGAGCCCNATAGTGAGTCGT ATTACAGGGGCGGCCGCTCTANAACTAGTGNATACCCCCGGGCTGCATGCTCCCCNCNCG

TTGCNCTCTTTNCNGCTCGCCCCCTGTCCCNGCNCCCCCCGGGNTNTTCCNCANCNCATCC CGTNTCTATCCCCNNANTCCANAGANANANTGANNTTCNCTTGNATNAACGAGGAANCAT NTNGTCCTAAAAATCTTTCCNTTNTNNTNGNCCNNANNNGAATNCTNANTNAANTANNNT AGNACTCGGGCTNCCCGGCTTATNTATNNTAAANANGCCNCCTNNCCGCTNCNNCATATG TTTNNTCCTTCACCAOSπsπsπsrANTNTCTCCTTGNTNCGTTαsπW

NCTNCNNACTAANCNCCCNAANNCCNTNNNNCNNCATTCCNNNTAACNANGCCCTANGA ACTNTNTNNTTNCTTTCTATCCNNCACACCACCCNTTNATTTCTNGCTTCACTNNNNG^ CCTNTTCNAGNTTCATAATTNTTCCTNNTGTANNCTCCCTGCNAANCCAAAAANTNTTNNT TNTTCTTTCNCCNTCCNNANANCTNNTNNATANCATCTGCCANNGNCNCCTNCGCNAANT CTGCNCTCTCTNNTNTNATNTATGCCNGNATACCTTGTNCTGCTCATAATNATNATAN TT

NANATNNTSICCCTNTNATTTTCTCNAATCCNGTCTCCTANGCGNNNCTTAANACANCACNA TTNATTTT^CCCNCCNOSENTCC

CTTTCCCCTTTCNTNTTCNTCCACGCCCGTCNNTCCTANNTACTNNGCNCNCTNNTTNANCT C(^NNCCC<^CCTOSlNTCTTCCTTNCNαSINTNNTCTTNNTNTCAC^ ATAANTCTTACAGNTCCCTNAAGANTNTCACCNTCATATCTCTNT(^CNNTCCTCNNCNAN

TCCNTATCANNCGCGCTNCTTTATTTGAGTTAATTTGTNTTGTTNTCNTANCCGTTNTNGN^ CmNCTTTCCNGACNCGNTNINNNCCNNCT^

CTNTσsrτCACCTNANNNTCNNACα^CACTCCTTCAGNTCNACCGTNNCGANNNNTCGCNC TCATTCANAGAGNGCNCCG

TNAGNCCTATAGTGNNGTCGTANTTANAGGGGCGGCCCGCTCTAGAACTAGTGGATCCCC CGGGCTGCAGGAAATTCGGCACGAGGGCGTGACGTGCNNTNGCCGCCACCTGGTNNNCAT GGGNCANCACTTCCTGTTAAGANAANCCACNANGTGGAACGGNGACGANNTANACTNNN TNATCNGCTNTNTGNCAGGCTGTCANGAANTCANATAGGAGTNCCGTNCCCAGNACATCN NCNTTC INNNNNTGCTGNTGNTNAACNANGATNNGTTNAANAGNGNCNNNAACNT^^ CTGGGGGCACAGATTANNATCTANTNTGNNTTTNANCNGCTCNCGGACNCTTANNGNAAG GNCGNGNNCANGACNCTTNTNCTCCNGANNNAGCAGACCCGCACCNTTTANACAGAGGG TCANNAAOSINATANNTTTNTGTTGTGTTGANACNNGAACACCNACCTCTTTN^

CCGCAGANCCNCAANACTNTTGTTCGTNTGNNCNNGTANCNCCCCCCTCCTTTNCANNNA GGGCAT ΪNNAGCANAANACTANTNTTGTGNNNNTNAAA< NTGGGTGNCCαSITαsrCTCTTT NNACAATTANGTGNTNACAACTGNCTTOSINTTCTAAAANTNNNNCNTAANCGACNAA TNNGTNr NTCNATATrlNNTTGTTCT^ NNGTCTNTNCTCNCNNTAATTTANNTAAAATT^

TNNNTGGCNNGCTNNAANCTCCCTNGAACTT^ AAACACTCTTNNNTrlNTNTTCTTNG

TTTTCCCTCTATTCTTTTTTTATNTANANNTCTNNGTCTATTTGNG NTNNATTNTCTGTNCTCCANTANACTNANANGACTNTTNCTGTTTCTNANCTATTTTTCT^ TNCNATCNTCATCCCCG

TNAGNCCTATAGTGNNGTCGTANTTANAGGGGCGGCCCGCTCTAGAACTAGTGGATCCCC CGGGCTGCAGGAAATTCGGCACGAGGGCGTGACGTGCNNTNGCCGCCACCTGGTNNNCAT GGGNCANCACTTCCTGTTAAGANAANCCACNANGTGGAACGGNGACGANNTANACTNNN

TNATCNGCTNTNTGNCAGGCTGTCANGAANTCANATAGGAGTNCCGTNCCCAGNACATCN

NCNTTCNNNNNNTGCTGNTGNTNAA(^ANGATNNGTTNAANAGNGNCNNNAACNTNTAG

CTGGGGGCACAGATTANNATCTANTNTGNNTTTNANCNGCTCNCGGACNCTTANNGNAAG

GNCGNGNNCANGACNCTTNTNCTCCNGANNNAGCAGACCCGCACCNTTTANACAGAGGG TCANNAAOSINATANNTTTNTGTTGTC^

CCGCAGANC(^CAANACTNTTGTTCGTNTGNNCNNGTAN ^CCCCCCTCCTTTNCANNNA GGGCATNNNAGCANAANACTANTNTTGTG^πSlNNTNAAAαSITGGGTGNCCCNTCNCTCTTT NNACAATTANGTGNTNACAACTGNCTTCNNTTCTAAAANTNNNNCNTAANCGACNAAGAN T>WGTN1S[NTCNATATN]SINTTGTTC^ NNGTCTNTNCTCNCNNTAATTTANOT

TNNNTGGCNNGCTNNAANCTCCCTNGAACTTNTNTTNANTCNTTTNTNNTNACNTCNNTTN AAACACTCTTNNNTNNTNTTCTTNGGTNTTANNTTNNCTNT^ TTTTCCCTCTATTCTTTTTTTATNTANANNTCTNNGTCTATTTGNGNTNCGGN NTNNATTNTCTGTNCTCCANTANACTNANANGA TNCNATCNTCATCCCCG

TNNNNNAAANGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAATTCGGCACGAGGGTGATCTTACGTCCTTTTTAAAAGCCCTGCTGCTGCT GCTGCTGCTAGTCGTGTCTGACTCTGTGCGACCCCATAGATGGCAGCCCACCAGGCTCCCC

CATCCCTGGGATTCTCCAGGCAAGAACACTGGAGTGGGTTGCCATTTCCTTCTCCAATGCG TGAAAAGTGAAATTGCTCAGTCGTGTCCGACTCTTCACGACCCTATGGACTGCAGCCCACC AGGCTCCTCTGTCCATGGGATTTTCCAGGCAAGAGTACTGGAGTGGGTTTAAAAGCCCTA GGACTCTAGGAAAACCTCTCTCTTCATCTAGTGTGGAAAGCTTATTAAGAAAGGAGTGGA ATGAGCCTTACCAGATGGTTCCCAGGTGGTGCTAATGGTAAAGAGCCCACCTACCAATGC

AGGAGACATGAGAGACATGGATTCGATCTCTGGGTTGGGAAGATCCCCTGGAGAANGAA ATGGCAGTCTACACCGGTATTCTTGCCTGGAGAATCCCATGGACAGAGGAGCCTGGNGGC TGTANTCCATANGGNCACAAAAAAGTNTGAAGTGACCTAACATACATGGGAGNTAACAG GACATTTTAAGAAAAAAGGAAAAGCTTAACCNAAGGCNGGCTGTNCAAATCGTGAGAAA CTTNCCCNAAAGTNTTCTCTGAGNTATAAATGCCTGAAAANCNTCNCCAACCCCTTTTCTT

TTGGAAAAAAATGGCGGNGTATTTTTGCONNCCTT^^

NAAACCAAGCC^CTTAAAATNGGNAANNNTTTNTTGGGGGNAANCCTNAAAACCTCTTTT TTAAAAGGCCCCCTTGNTTTTTAAGGGNTNGGGGGCTGGGGAANAAANTGGGCCNAAAA ACCTGGGGGGTTGA

TNNAACAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGTTTCAGTCCTTTGGATCTACGTTTCCAATTAAGTATTAGTCAAGTATTAACAG

CACAAGTAATGGGTTAACTTTAGACTAGGAATTGGTGTTGGGGTGGGGGGTGCAAGAATC TTTATTTTATTTTATTTTTTTGGATAAAAGTT^

TGTGCTGCAAAGCCATAGCAGATTTGAGGCGCTTTTGAGGGCCGAATTATTCTCCAAGTTG AGAGATGTCCTCGGGTTGAATTGAAAGCCCTACCCAAAACTGCAGTGGGAAGGGGGAGA GCCTTTGCCTCCACTGCCCCACCCTCACCCTCCTCGTAGACCCTCTGCCTTTTGAAAGCAG ATCATTTTCACTGAGATGTTGGACATTGCAGATGTCTGTTCCCCAGGCCAGCAGGGACCTC

TGAAACCTTCATGGCCTGGCCTTTTTTTTTTTCAANCCNGGGGTTTTCCAAAGGGA NGGATTTTGGAAATCGAAAANTTTTCCAAGCTNTATTTCTNAAATTTNANAACCTTT NAAGGTNAAATTGGAAGGGCTTGTTTGNAAACCTTNACCCCCCTTGAAANCCCCCCCTTA ATGAAAAAACCTTGGGGGGTGGCNTNAAAAAAAAGGANGGTGGGNATTNAAAGTTTAAA AANNNCCCGGTTTTTTGAAGGCCNAAATTNCCCCTTGGGGAATTAAANNATTTCCNGGGT

TTTCCTTGGCCCCNTTTAACCCTTTGGTGGNCCTGGGGAAGGGAATTGGGGGNAAAAAAA AATGGTTGGTTTTTTNCCCCAAACCTAACCCCCAATTTCNTTGGAATTAAAAAATGAAATT TNAAAGNTT1 NNTTTTTGGCAAAAAAAAGGGCCTTTTTGGCCGGNT

TTGANACAANCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCTCNNGNNACNANGTTTTTTT^WTTNCNGCTGGGNTGNACCTGTNCNCGGGN NGNCNATGGNNCCCACCTGGNCCCTAACCTGCTCCTCCTTGGCTATGANCCCACCAGGGA CATCCCTGGCTCCTGNTGGCCGTAGNGNGCTGGCATGGCCCACCTNGGGGCTNACCTGCT GCNNGCNGACTTGCTTCCCGGCCTGANCCTGTNACCTTGNTCNCTACTGGTAACCNNTCCT

TNACNNGNNGCCTTTNCANGGGNCNTACCCCANGGGANTGATTCTTCTGCNCTGNTCCTA CCTTNGCTTATTTCTTGGNCGCTTNGGTTTCCTNNCTTGGGTACANACCCTGGTNTTCTGNT GGNNTNANGAATGCTCNCTCNTGNGCCNGNAANTGAATCTTCNCTTGGGGNNAANTGANN ANTCTNTTTNNANGGGGTNNNTNGAANNC(^GTNNNTACCTNNGCNNNGGNAAACANAN ANCNTGGATNTCTNGNCNCGCNTGNNCTTTGGGNTCANAATNCCATGCNNTNGGGNNANA

ACCTANNNCNTAGNGTTTNNGNANCCCαWCNNGGGGGGNNTNCNCCTGNNTGANANTTT TNNTATTNAANATCCTTTNCGGGCTCTNAAGGGNTTANNNNGGNGCCCCNCAAαsrTTTCA CNATNTCGNGNNNCCCCNCNANNAAAANAAAANCNNCCTNNTTCTTTNCCαSTGTCGCTCN CAANNACANCCCrø«π JNNNGNCNTCANNAANGNNGGNGCTTCNNTNTCTNCCTANANTNN NNTSINNTWTCNNCCNANNNTCAA

TCCGTNTNCCGTGTGNNNCATCTαSTTCTN^

CNTNNACTTNNTNNCCNATCNTTNNGTCNCNTANNTNTNANCNCANGCTGCNNCCTCTCC AACTNTNCATTCTCGNCNCNGCNNTTCCNNTTTNNTCANTANCANQWCNCATCNTACTNT CGNTNANATGCTNTGTNNTNCTCTGCTTNNCNCNTTTCNCTCNNTNCCA

TTNANAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGGTCCGAGTCCTCTGATGTCCTGTCCAAGTGAAAGGCTCCT GCGGTCCCTCCCAGCCTCTCCGGCTCATTGGCTCCTGCAGATGGAGCTGTGCAGGGGAGC ATCTGCACAGGAGACCTGAGGTTTCGCCCCTGTCCTCCGCCCACACCTGGGGGGAGTCGA

CTGCCTGGGGTTGCCCCTTTCGCCCATGACCCCACCTAAAAGCCAATGTAAGCGTCTTTTT CAGAATAAATCCAATTCGAGTAAAAAAAAAAAAAAAAANNTGGGGGGGGGNCCNGGNCC CNATTNCCCCTTOTNGGGNNNGNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNΠSINNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNTSINNNNNNNNN^ NNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNN^

NNNNNNNNNNNNNNTSINNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNKNNNTSΠSΓNΓNNNNNNNNNNNN

ANNACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGTCCTTTATTCCTACTCAGACTGTTGCACATACTAGCCTTGGGAGT TCCTAGAATAGAAATCCTTAGGTTTTAATTCCAGTCCTGTTTCCACCTACAGAGTCCCAAC GTGGTTATTGCAGGCAACGTTCCCTCTCTCCGTGGTCTAGAAGCCCCTCCCCCAAGGTAGA AAGAAGGGAAGAAGCTAACTCCAGTGTTTCCGTTGCACTGATCCCCAATTCAGTCCAGGA GGGGGCTTGGTAACCCCTCTCCCTCAATATCCTGGCACCTTGGGCTTGTGAACGCCTCCTA GCCAAATCACTAGAGTACAGTGACCCCAGCCTCCTGCCTGTCCCGAGTGAGCCCTCCCCAC CCTGACCGTGCTAACTGTGTGTACATATATATTCTACATATATGTATATTAAACCCGCACT GNCATGTGTACCCTTTTTCTGTGGNGTCTAGCATTAACTTATTGTCAAGGCCCGGGCGGGG

GTGGAAGGAGAATGCCACAGTGAAGGGAGTGGCANAGTCAAATTGCTATATAGTCGAAA AAGAAAACTTTTTTAAACTTTAATTTCACATGCAATCTCAAGAGACTATTTAGAGAGTT^ AGTGAGGNGGGGGAGCTTTTGGGATGTTGGGGAACAAAACTTCANTGGGAAGGAAAGGG CTGGTTGTTGGAGAAGGGAACAANCCCACTGGNTGGAGAAGCACCCTTTTACAANCCAAG CCCANACCCANACCGGTNCCCTTTNGCCACTTGTGGGGGACNCCTNCCTTTAAAACANAC

ACCTTCNGNGGTNCTNCCACAAGTTTTNCCTTAAANGAACCTTCCCNAGATTTCCCCNACC αsmslTCTNGGGTTTCTCCCN(^AGNANGAGAANANAANCNTTTGANAANTTGNGGANGTG GAAAANNAAC^TGAATTTNTCCNTTCCAACNAGGCT

GNCCNATNNGGGANGNNGCATNACAGGNGGCNGGCCGCTCTAGTAACTAGTGGATCCCC CGGGCTGCAGGNAATCNCGGCCACGAGGGCTGNTATGCANCAATANGCATTAATCATGTT AATAANNGGNGGGGGAGGAACTACTTTCATGATAGNGNNANNNNNNNNCTCGNGATNNG ANACNANAGGGCCNCTNTTGCGANNANTTGCNNTNTACNAGCNCNGGNCTGTNACTCNCN TATAANCACANNNNTGNTNAGTGNNTNNCCNAANCTCGNTNATCNGAANNNTNTGNNAA

(^TGCANTGTNCAAGAGACOSINATNCTATGNNNGNNNNTGGGTNGACCTTNCANTCACGC GTNNNATNNANTNCGANTGNNNGTCGATCTNCTCNNNNCATGGNNTCTNATATNTCATGN GNNNGANAGTCGNATCATNANNGANTANNTANNNGGANTTNCTNCTNNGATATTCTTNCC NCNGNTCNTNGACANGACGCACACGNACNNCACACGCAGTNNGTNNGNANGNAAGATNC NTNNTATNGCCACNANAGNNNGNAAGANTANACGAGTTNTNNACATCNTNAGNGNGCGA

TACNCNAGTTCNNNACGNNTTANANNNAGTAGCGN^INGNGNTCNCNAGTTTTAATGTCNC TNGNCANNGNCNNACNCANNNNNNTCATNATTTNNTCNNNNNANATGNCANOWATNAG TNNGTNGCNNCNNGCNNNNNNCGTGANNCCCANATGNTNCNTNCATGATCTCANTTANAN NGGAGTNNTGACAANANTNTNTTGANANTNNGTTNACAGTCNAGNAGANNCCATCAGNN NGNNACANATNNNNGNACNCTNNTGTTTTTTNNNTCGACAGTANTNTANGTT^

NATAGAGNNNAGTAGTCTGNTNNCAGANACTCTAGNAGACNCNTNNGNNCCTTNNTAGTT NATANTNNATNNTNTNCNCGTNNGACTOSINNNANACTTCTNNTCNACTTTT^ GT(^CAAGANACCGATTGTGATNANCCTANNNTNACGTNTTCGGAGGAGANNNNCGATTC OSfCNACTNTNOSπS[CCANGGTCTNCCTNGTNGCCTCNGACNAACNNTATN(^CTCCTGTTA GTAGCATNNACG( NGAGNNGNTANTTNNATNTTGNAGCTTCATGTTNATGGTAGTNTGAT

GTANGTAGTAGGAATGAAGAANNTGGAANTAGNGANAAATAAANAGNANAAGTCGNAA GCANAAANTAAAGGANGNNNGACGNACGCNATCANTAACCTCNNTNNNNATNTCGTTCC TCCGTCT

TACTAANGGGAGGGACNCANNNAACNCNNNANNTTGGNGCTNGAGGCCCTCATAGTGAG TCCGCATTACAGTGGTNNCCGCCCCTACTNTNNAGNGTGATCNAACCANANTACCATTAC NCATTATITCCCNNNTAATNTTTATTTATCTNCACNANNACAANCTCTGATANCNTNTTCG NTO^NNGGGNTTATCNTNTGCNNCTNGGTTNNAANNCATNNACCCTANATCTGNCNCNAN CCCTTATTCTTCAANNTANGANTNCGNNCNCATCNTNATTATNNATAGANNNNTNTANTCT

NNNNACNGNAATCAAAGQINCNNTNTNTTTTCTNT^ CCCAGGANNCGNTNCANTTNTAATTATATGTCNCTNTO^

TTTTNTTCTTACGCGTNAACNANTGTNCNATATANNNTTTGTANCGATNAGGCACNNNNN NATTAANTTTNGTGTCTATACTNTNNNCCGNNACJWCGNAANNCCATTTTCTATCNTNGNT NTANNCAACNTCNNCAATNTNNTΓΛINNTTNNNNANNT^^

NTTNANNCTATTNGNCOSINCTNNCCCAGACNN^

ANCTNCATGGNτ>[NCTATTTNGA^TATN(^AAATANTNTTNNTATATNATNCAAANNNAT ANGTTTNNCTATAAGTTATNNANNTCAAGNGGANNNANTAANACGCTCCANGCTANGTTN TCTOSπSTGANNCTNTGAGATATAAAANNNNTNTNNAGNNCNNNGATANNGCAATNTT^ NGTTTGNCCTTNTATCCTATNGNNTATNN^

AATNTTNANTNTNATTTNTNNTNACATA^

NATNAANCCC^GNCGTTCTCCTCTCTCACCTNTCNCCTCATCACTTTACTAATNTNTAATN AT< ACGCGNTNCGCTTNNANANGTQvINNANN^ CAGCCNANNATNNTCCTTAATTACNTGTGCTCTGC WATGTTATCATTTACANGANNNGA NTCCTATNTTCTNNATTNNNTCTNGNANTNNNTCANNNGATANNTATACCTATATTAC

CTCTNCAATNTTACAGNTNTAATANNNGCNNGACANTNTATGATGNANCGNTATATGTAN

ANTACTCATATCNNCGTGNGCGTTACNANNTNC^ATATCTCCTCANAANGTNNCTNCCTTT

NTCAGTGACACAANATNNGATNNTGNCCGCTANAGNNGNNTGGTNANNNNGNATNTNAG

TATCATTATNTATTANTNGTNCGCTCACATANACGNNGNN(^GNCGNCTNNNCTNTATTN

NCATATATNAACGNNTCNCTAAACANNTAATNNNTAGAGTCC

TNAGCCTATNNGGAGNTNNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGNAGGANTTCGGCACGAGGCCCTGACGTGCACATGCGGGACCTGGTGGGCATGGAACA

CNATTTCTTGCCANGTGAACCCANCNANTNGAACGGGGNCCANNNNTANCANNTNNTTCN NTNTTTTGCNNGNTNGOSrAGAAATNGCAAANGAATTNCCTNCCCANGAAAANGACNGGC NANCNCTNNTNNTGNTNAAGGNNGANCACCTGANGAATGNCATNAACNTTAANCTGGGG CCANCCCTTAAGAANTACNCACGTATNAGCATGCNNAANGACNTTAAGGCTNGNCGGCGC CGGGCTTCTCCTCCCGAACGAGCANAAACCGGTNGACACTCTTGNGGGGCCCAAAGNACA

GGGCGGTCAAGGGAAGGGCCCCCGCTGCCGGGGCGTACCTGTGGGAGGAGGTCTCNNGA CCTCCTTGTGGGGCTCTCAANNGGCCTTTCTTTNTGTGGGAGNGGCACAAAGGTANGTGG CACACAANATGGGGCTNTATGCTTNTANAATATTGGTGACACTGTNTTTTTCCANANTNCC ACGACTCTAGCCCCGCTTCTTTTTCNCTNTTTTTTGTGCCCCATTNTTCAAGGGGTANTATG GNCANGGCTTCCCANCCTGNGGTGGGGNNATTTTTCCCAGGNGNANCCNNCCGGGCNCTT

CAAGAAAAAGGNCTT<^TAAANCCCTCCNNCTGGCNTTTCT^ GGCCCAACCATTNTTTNTTCNCGNTGGCAGCCTTITTTTCCACTTTAAAAACT^ NAANNCCGCCCANAAAGGNGNGNTTCCCNTCNTACCCCCNTCCAAGGNGGGANGGAAAA AAAAAAATTTGNTNCCGGNTTTGTTTCANCCCCCTC^ NCTTTGNNGGGNGAAANNGNNTTGC

TNAGCCTATNNGGAGNTNNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGNAGGANTTCGGCACGAGGCCCTGACGTGCACATGCGGGACCTGGTGGGCATGGAACA CNATTTCTTGCCANGTGAACCCANΑSIANTNGAACGGGGNCCANNNNTANCANNTNNTTCN

NTNTTTTGC3SINGNTNGCNAGAAATNGCAAANGAATTNCCTNCCCANGAAAANGACNGGC NANCNCTNNTNNTGNTNAAGGNNGANCACCTGANGAATGNCATNAACNTTAANCTGGGG CCANCCCTTAAGAANTACNCACGTATNAGCATGCNNAANGACNTTAAGGCTNGNCGGCGC CGGGCTTCTCCTCCCGAACGAGCANAAACCGGTNGACACTCTTGNGGGGCCCAAAGNACA GGGCGGTCAAGGGAAGGGCCCCCGCTGCCGGGGCGTACCTGTGGGAGGAGGTCTCNNGA

CCTCCTTGTGGGGCTCTCAANNGGCCTTTCTTTNTGTGGGAGNGGCACAAAGGTANGTGG CACACAANATGGGGCTNTATGCTTNTANAATATTGGTGACACTGTNTTTTTCCANANTNCC ACGACTCTAGCCCCGCTTCTTTTTCNCTNTTTTTTGTGCCCCATTNTTCAAGGGGTAJ^ GNCANGGCTTCCCANCCTGNGGTGGGGNNATTTTTCCCAGGNGNANCCNNCCGGGCNCTT CAAGAAAAAGGNCTT<^TAAANCCCTCCNNCTGGCN^

GGCCCAACCATTNTTTNTTCNCGNTGGCAGCCTTTTTTTCCACTTTAAAAACTTNT^ NAANNCCGCCCANAAAGGNGNGNTTCCCNTCNTACCCCCNTCCAAGGNGGGANGGAAAA AAAAAAATTTGNTNCCGGNTTTGTTTCANCCCCCTCCTTΓGGTTNNAAACCCCNTTAAATC NCTTTGNNGGGNGAAANNGNNTTGC

TNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAANCCGNTGNCNANNCTCAACCANCCATAAAGATATTGGNACCCTTTATCTA CTATTGGGNGCTTGGGCCGGNNTAGTAGGAACAGCTCTAAGCCTTCTAATTCGCGCTGAA

TNAGGCCAACCCGGAACTCTGCTCGGAGACGACCAAATCTACAACGTAGTTGTANCCGCA CACGCATTTGNAATAATCTTCTTCATAGTAATACCAATCATAATTGGNGGATTCGGTANCT GACTTGTNCCCCTAATAATGGGTGCTCCCGATATAGCATTTCCCCGAATAAATAATATAAG CTTCTGACTCCTCCCTTCCTTATTCCTACTACTCCTCGCATCCTNTATAGTTGAAGCTGGGG CANGAACAGGCTGAACCGNGTNCCCTCCCTTACAGGCAACCTANCCCATGGCAGGACCTT

AAGTANATCTAACCATTTTNTNTTTACACTTAGCAGGAGTTTCCTCAATTTTAGGAGCCAT CAACTTCATTACAACAATTATCAACATAAAGCCCCCCGCAANGTCACAATACCAAACCCC TNTGTTGGAATGANCCGNAATAATNACCGGCCGNACTACTACTAACTTTTNGTTCCCTGGA TTANCAGCCGGCATCACAATGCTNTTAACAGAACCGGAACCTAAATACAACCTTTTTTCGA CCCGGNNGGAGGAGGAAACCCTATTNTATTTCAACCCTTTATTCTGATTNTTTGGGACCCC CCGAAGGCTATATTTTAAANCTTANCNGGGGTTGGGAAAAAATCCNTTCATATTNGGGAC CCTACTTCCTTCNGGGAAAAAAAANAAACCNNTT(^GGAAATTTTGGGGAANAGGNTTGG GGCCTTTAAANGGCAAANNGGAATTTNTAGGGGTTCAATCGGAANGAAC

TTGAAACCACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCNCCCGGGCT

GCAGGNTIT^AGTCCTTNGGATNTANNNTCNAANNAAGTATTAGTCAAGTATTNGGNNGCA

CAAGTAATGGGNTAACTTTACACTANGAATTGGCGNTNGGGTGGAGGGTGCATGAATCNT TATTCTATTTNATTTTTTNGGATANAAGNTNTATCTATTATANATTAANCGCNCTTGCTGA

NNNNTGCANAACCATANATAAATTNNANGNTAΛCTTTNAGGGCTGGANTGCTTCTCNNNN TNCNGNANATGNCCNNAAGNATTCGAATNGANACCCCNAANCAGAAAANNTTGNANNGG NCAGGNNGAAATGNTTNTACCTTCGTTGGGNNGANCCTCACCGAAATNTTTNACCCTGCA GANNNTTGGGOSIATACNGCTNNNTCTANNCNTGTNGNNACANNCTTTNCCNAATGCNNTA TCTCATCTCTNTNNGTTTCCNNNTTNTNCCTNNNNNTGNCCNTTGCNTTT^^

TTTOSINNTNGTNGCNTTTTTNAC^ NTNNIWACNAN NCI ^TIT.^AQ^^ GTNNTNNNTTTNATNTCCNGNCNNCT TTNGNNATNNCTTCTTCTTANGNNNCANNNNANTNCNATTCNTGNATACATTTNTGANNA NCTTTATNTTNNGNATACTCTNACNNCAANNNNNANCAGANNTCCCNTAACTATAANTAC

ACTTTTTTTATATTNTTNACCCGNGGNNNATANAGAATACANACNCTNGACATNCTNCTTG ACGTNANGACCGTNNNNACTTNTT(^AC^AGANCCNTTAGANGTNTTNACNNNTTT^ AATNTNAANCCCCNTCATGNNTCTCACGANTGCTCTATTATTNNTNANACNGATTTCNTAC NCTAGCNATANCAGCTGANGTTANTCCCTNCCG

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCCGCCATGGGCCGCGTGATTCGTGGGCAGAGGAAGGGCGCCGGCTCCGTGTTCCGCG CACATGTGAAGCACAGAAAAGGCGCCGCGCGCCTACGCGCCGTGGATTTCGCCGAGCGAC ACGGATATATCAAGGGCATCGTGAAGGACATCATCCACGACCCGGGCCGCGGAGCGCCCC

TTGCCAAAGTGGTTΓTCCGGGATCCGTACCGTTTTAAGAAGCGGACAGAGCTGTTCATCGC TGCTGAGGGCATCCACACCGGCCAGTTTGTGTACTGCGGCAAGAAGGCCCAGCTCAACAT CGGCAACGTGCTCCCGGTGGGCACCATGCCTGAGGGCACCATCGTGTGTTGTCTGGANGA GAAGCCTGGTGACCGAGGCAAGCTGGCAAGAGCCTCTGGAAACTATGCCACAGTCATCTN CCACAACCCTGAGACAAAANAAGACGCGAGTGAAGCTTGCCTTCGGCTTCCAAAAAGGTC

ATNTTCTTCTGCCAACAGANCTGTGGTCGGTGTGGTGGCTTGGAGGTGGNCCGCATTTGAC AAGCCCATTCTGAAGGCCGGCCGTGCCTTACCACAAGTATTAAGGCAAAAGAGGAACTGG TTGGCCACGGGTGGCGGGGTGTGGGCATGAAACCCTTGTCGAGCATTCCNTTTGGANGGN GGCAACCANCCAACACATTGGGCAAANCCTT1 ATTNTTTGCAAAAAACCCCCCCTTGTTG GGCCCGGAAAGNGGGTTTTNANTTGGTTGNCCCGCCGGAAAAGGNCCGTTTTCNGGGGAA

ACCAAAAAATGGGCCGGGGAAAANGGANAAACTTAGGGNTTGGGGGTTTAAAANAAAAG NTTGGTTTTTTTTTNCCAACTTGGAAAAAAAAAAAAAAAAAAAAAAAC GGCCCGGGGCCCCCA Π TTTTNT

TTGANAACGCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGGGACTNGTTCTCTNANGCTGTCAAAGTGGCAGAACTCGAGA

AGCGCCTGACAGAGCTGGAAGCCACTGTACGCTGTGATCANGATGCTCAGAATCCCCTTT

CANNAGNTCTNCANGGAGCCTGNCTCATGTGTACTGCNTNNANACNTNGGGGNGANTCNC ACTNGCΣSTTGTGGTTGNTNCTTTCGTCT^ANTACCCACNATNNTTNΑSINNTGGATN^

NGTNTTTTCAAGANTNNATGCTNTTCNCNN^

GGGCCCC JAACCCNNATNNTCCAATTATTTGNR^^

TTTNTCTTTGTTCTTNATGTNAATATTNACTTGCCTCCATCANTC^GTCTTGNANGATCAAA

GTNATN<^TTTTTTGNTTCANNTTTTNGACTCCTNTTGGTAT^^ TTNNTTTTGTTNCCTC ITTNCTAT^^

TNNATTGTNNTNAACANCNTGCTTATCTTCTTNAAGGTNGACTTTTNNCCANCAT^

NCNTATNC^TNNCTTTACTCWTTTTΓGNA(^TNNNCTCTCTT^

NNNNGNNNATCTTATCNNCTNTΠ^

TANTTGTNTNTCNTNCNTNNANNNAATCTTΣSFCTT(^CTANTTTTANT^ AGNNTATGTNCTTNTTTATNACTNTTTAGAGNCTAGTATATTTTATG(-MNT^ NTTNANNNACTNGNTGANTTTTNGNTATATTTTAATNGNTTTNN(^

TCTCTTNCTTGNTNTAGCGGTNGAGNACTCCNTTANTGGTCTNCGTACGTCTCTCTCTANCT NCTCNTTTCNNCTCG

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGGGGGCGGTGGCGGCGGTGGCTGGCGGTTCGGCAGTGAGTGCAA GGATCACCATGATTCTTCAGAGACTCTTCAGGTTGTCCTCTGCTGTTCAGTCTGCAATCTCA GTCTCTTGGAGGAGGAACATTGGTATTACAGCAGTGGCATTTAATAAGGAGCTTGATCCT

GTGCAGAAACTCTTCGTGGACAAGATTAGAGAATATAGAACTAAGCGACAGACATCTGGA GGACCTGTTGATGCTGGCCCAGAATATCAGCAAGACCTAGACCGGGAGCTTTTTAAACTT AAGCAAATGTATGGTAAAGCAGACATGAATACGTTCCCTAACTTCACGTTTGAAGACCCC AAGTTCGAAGTTGTCGAGAAACCACAATCCTGAAGAAGTAATGTAAAATTGATCTGGTAA TTTGTCCTAGATTAGTTGTACAGCTGGCCACAAGTAACAGAATAAACATTTCATAGCTGTC

AAATGTTCTTTTAATTCTGATTTCAAATAAATTATTTGGTGATGTTAGGTAAAAAAAAAAA AAAAAACNTCGGGGGGGGCCCCGGTNCCCAATTNCCCCTTTNGGGGGGNNGNNNNNGAN NNNCNNTNNANGNNNTCMSTCNNANNCCCNANCCCTNGNNCOsINT^^ CCNNNN1SINGNNNAAAACNNTNNG NNNANNN< NT WTNNNTNNNNNNCNNGTTNNNr^

TGGNNNNr^NNCNCNTNGGNNNNN^ GNNN NNANNNNNNNNGGT^^ NNNNNNCNNNNNNNNNNNNNNTNNNNNC

GCCTATNNNGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCTTGTAGTTGTCATCCTTGACCTGGCTAAGCCCTGGGAGTGTT AGTGTAGATCCCATGGGATCTATGTTGTCTCTTTΓATGCCACCGTGGGGCATTTTGTTAATT TGCTACTCTACCTTGAATGGAAAACAGGGCCTTGGTCAGAAAAAGAATGCTCTGGACACT GCTAAGGACTTAGAGTCAGCCCATGGTGATTGTTTGGCTTCTTGNTGTCTGCCTCTTCTTTC

CTAGTGTCTGCCTGGCTCTTTANCACAACCTCCCAAGGGTGGACAGGGGGAAAGTTGGTG GTGTCAAAGGTCAAAACTATGGTGTAGAACAGTGCTCGAGACCCTCTGTGATCTTTCTAAA TGAACAGAAATTGATCCATACCAACGAGGGGGCAACTTGTCAATTTCTTTAATGTCTCAAT ATTAACTGGAATGCTGCCTTGNGGGTTCTCACCTGCNTGAATGTTTTGAATTGGATGTNAT ACTGGCTATAAGTCTCCAAAGGAATAACTGACTCAACTATTTACCCTGTTTACTCCAGTAA

ACAAGTTTTCCTCATCCCCTCAGNGTAAAAATCCTTCAAAAGGTAGGCGAATTTGCTTCTG GGGTGTTAAAAGCGTANGTGGGGATATTTTGAAGGGAGGAAAAGTCNNGTTCNGGCANA AAGGNGTTTTCCCCCNNTAAAANCTTAAGGTATTTNNCTTGNNTNNGGGTTTTAA^ CTAAAACTTTTGNANGGAAAAGGNTTCOSFCCCCCTTACNAANGAAAAAACNTGCTTNNAA AAANCCAAAANNGGNNTTNGNAANGAAAAAAAAANGGGGNNAAAANGAAACNTTTNCC

CTGGAANNTTNTTCTTTNGGGNC WGGGNAAAANACANCAAAAAGGTGAAAAATATTTTT CTTTNTTTANAAAAGGNCANCTACACCCCTTGTGGNAAANNNNNNNNNCACCCCTATCT

GCCCTATAGNGAGTCGTATTNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGAAGGTGCCCATNANGCGCTCNGAAATGCTAAGGGATATCA TCCGTGAATACACTGATGTGTATCCAGAAATCATTGAACGTGCATGCTTTGTCCTGGAGAA NAAATTTGGAATTCAACTGAAAGAAATTGACAAGGAAGAACACCTGTATATTCTCATCAG CACCCCTGAGTCCCTGGCTGGCATACTGGGAACGACCAAAGACACACCAAAACTGGGTCT CCTTTTANTGATTCTGGGNGNCATCTTCATGAATGGCAACCGTGCCANNGAAGCTGTCCTC

TGGGAGGCACTACGCAAGATGGGACTGCGTCCTGGGGNAAGACATCCCCTNCTTGGAGAN CTGAGGAAGCTTCTNACTTA(^AATTTGTAAAACAAAAGTACCTAGACTACAGACGAGTA CCCAACAGCAACCCTCCTGAGTATGAGTTTCCTCTGGGGCCTCCGATCCTACCATGAGACT ATCAAGANTGAANAGTGCTACGATTCATTGCTGAGGTTCAGANGAGAGACCCCCTGTNAC TTGGACTGCACAGATTCATGGAGGCCCCCANAANNAAGCCCTNGGATGCTTTNGTATGCT

NCTNTCCCCCCATNGCTTGANAGCACGGGCTGTAGGCGANNAACCCCCCCNTGGGGGAAT TNGGNGAATGAANGNNCGTANTCTTNNNGCCCTTGTGNAGCCTTGGAATGANCAATTNTA TTTTTTAACCTGCTGANNNGTGGGGATNAATGGAANTGGNGAATTTNTGNTNGAANCCCN TGGTNCCAGAATTNCCCACTTTAACCTTNTTGGGGCCCNCNATACTNCCCNAANAATAGN CTTTCT⁽^CCATNATTTTCNTAAAA GNGCTNACNAAAACCAANTTCCCNNNCNTC

NCCOSrCAGNCAANNNTTTTANTNTNNNNNTTTNNTTNNNNT^

TANTNTTTTTTTTACCTANTCTNTTGGNNNNGNNNNCGNTNTNACCT^ CTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGAATTCGGCA CGAGGTTGTNANTTACCAATTACCTGNGGTATTGGAGAAGACTCTTGAGAGCCCCTTGGA CTGCAAGGAGATCCATCCAGTCCATCCTAAAGGAGATCAGTCCTGGGTGTTCATTGGAAG GACTGATGTTGAAGCTGAAACTCCAATACTTTGGCCACCTGATGCAAAGAGCTGANTCAT

GTGAAAAGACCCTGATGCTGGCAAAGATTGAGGGCAGGAGGATCAAGGGGACGACNTNA NGATGGCNTCACCGACACAATGGACATGGGTTTGGGTGGACTCCCACAGTTGGTGATGGA CATGGGAGGCCTGGCGTGCTGTGGTTCATGGGGTCACNAAGAGTCGGACAAGACTNGAGC GACTTGAANTTTAACTGAACTGNNNNTACCTCTCCTNα NTCTTGGANNATANCCNCCTTA CNCTCTNCTTTCCTNAAACTGGANTNTTTGAACCTTTTNCTNGCCC(^GGGCCATTGNCTTT

TAAATANTGGGTCCAATCTTNANNTGCCCATTATTAGNAAGNGTTTAAAAAGCANCTTTTT CTTNATTTNTTTAAAAANTAAAAAAAAANNAAT^ NNTNNNCNTTCTTTNNCTTC(^ATG^ NTTTTCNNNATTNCNNNNANTANNAAACTTACTNACNNCCCGTGTNCCWTCGCNNTTGTAT TTCNTCCGGGGNTCNNCCNNTTANGNNTCTCCCΗTTNCCCNTCATGNTANTNTTNTNNTNA

GATNTCCTATCTCTNNCTATNCCTCGTANGTCTCCTTCGATTTCAACATNGNTANACCCNC TNGNATGTNTTCTNACCTNTCGANGTCCTGCTCGGNNNGCTCTNCNCNCGTATTCTCTCAN NNTGTTNGGCACTCGCACNNANTTNCTACNCACTCTTGNAGGGTTNTNCNTANTNAGCAC GCCTNNNTATAC MNTCACCTACNANNNTCCTNNCCGNGANTNTGNANNCGNANNTTTTN TGTTCCTCACNNNTNATATCTCTGTCGCCNNGGAGTGTNTTAACGACTNTCTCTTGTNCTN

CGTTTGNACGCACNCTCCGNNANGNTGCCNACNCNCCG

NCCCNCAGNCAANNNTTTTANTNTNNIS^ TANTNTTTTTTTTACCTANTCTNTTGGNNNNGNNNNCGNTNTNACC

CTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGAATTCGGCA CGAGGTTGTNANTTACCAATTACCTGNGGTATTGGAGAAGACTCTTGAGAGCCCCTTGGA CTGCAAGGAGATCCATCCAGTCCATCCTAAAGGAGATCAGTCCTGGGTGTTCATTGGAAG GACTGATGTTGAAGCTGAAACTCCAATACTTTGGCCACCTGATGCAAAGAGCTGANTCAT GTGAAAAGACCCTGATGCTGGCAAAGATTGAGGGCAGGAGGATCAAGGGGACGACNTNA

NGATGGCNTCACCGACACAATGGACATGGGTTTGGGTGGACTCCCACAGTTGGTGATGGA CATGGGAGGCCTGGCGTGCTGTGGTTCATGGGGTCACNAAGAGTCGGACAAGACTNGAGC GACTTGAANTTTAACTGAACTGNNNNTACCTCTCCTNCNNTCTTGGANNATANCCNCCTTA (^CTCTNCTTTCCTNAAACTGGANTNTTTGA^ TAAATANTGGGTCCAATCTTNANNTGCCCATTATTAGNAAGNGTTTAAAAAGCANCTTTTT

CTTNATTTNTTTAAAAANTAAAAAAAAANNAATTTGGGACCATCTTNNCCCNTT^ NNTISINNCNTTCTTTNNCTTCCN^ NTTTTCNNNATTNCNNNNANTANNA TTCNTCCGGGGNTCNNCCNNTTANGNNTCTCCCNTTNCCC^TCATGNTANTNTTNTNNTNA GATNTCCTATCTCTNNCTATNCCTCGTANGTCTCCTTCGATTTCAACATNGNTANACCCNC

TNGNATGTNTTCTNACCTNTCGANGTCCTGCTCGGNNNGCTCTNCNCNCGTATTCTCTCAN NNTGTTNGGCACTCGCACNNANTTNCTACNCACTCTTGNAGGGTTNTNCNTANTNAGCAC GCCTNNNTATACNNNTCACCTACNANNNTCCTNNCCGNGANTNTGNANNCGNANNTTTTN TGTTCCTCACNNNTNATATCTCTGTCGCCNNGGAGTGTNTTAACGACTNTCTCTTGTNCTN CGTTTGNACGCACNCTCCGNNANGNTGCCNACNCNCCG

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGANTTCGGCACGAGGCTGNAGCCCTCCGNGATGTNTCTGAGGAGTTGANCCGN CANCTGGATGACATCCTCANNACATACTGCGTGGACAACAGNNANNGGGGCCCAGGTNA

GGATGTGGCANAGGGNGAGCCTGCTGAACCCGAAGATGCANAGAAGNCCNGGACCTATN CCTCANGGANTGGGNAGCCTGAGCCAGATACTCCAGTAGTCNNTGNNGAGAAGGAANNC TCCAAGGGGGAGCCGGGCCCGGTCTAGATCCTGTACCAGNGATGAAGTTTGAGACCGANA CCACCCAAAGCCNCNGGATANTAAGAAANNCTANGGTGTGGGAANGGAAATTACCTTGC CCACTTTANNTNCCNCTTAAAGCCTANAGNGGTGGCAGGGAAGGNACTGNCNCNNCCCNN TGTGGTGTGGCCAGGTTGCAGTNNTNAAAAACCCAAGCTTACTTGGTTGGTGGGCAANGN GGGCCCCACTTGGCCGGGNNGGGGCTTTTGTTCTCAANTTCACCCTTNCGTGTGTAGCCTT CCANGNCAGGCTTGANGGNGGGGTCCCANTTGTTTCCGTTGANCCAAATTTTTTTAAATAC TTAAAGNTGNTNTTGGTTTGNTTTTGGT ^

GCCCCαSICCCACCCAGGGTCCTTGGGNCCAAAATNAAAAAGGGGGNCTTTTCCTTGAAAT GAAAGGCCCΗTTTCCTTTCπCCCTTGGGGGrø^

TTTGGACCCAAAAACTTGGGGNGGGTTINTTAAAAANGGNNNNCNTTTTCCCTTTAAGGG GGACCCCCCCGGGGGGGGAGGGNNTTTTNTTNAAAANAAACTTTGGGTTCAAGGGNNTTT GGCCCCNNTTNAAAAACTTT

TTGAACACAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGCTTTGTTCTGGAGTATGAGGCCTCAGCCCCGGAGGCCCAGTGATGCCAGGGGC TCAGGTGTTCCAGGGACTGAGCCGCAGTGGTCCCCAAACCCTGCGTGTGCTTGTGACAAA

CAAAACCTGTCGGCTTCCTAGCATTTACTTTCTGCTTCAGAGGAAGGAAATGGGAATGCTA ATTTTTAAAAGACAACTGGATTTTGAGACTTTATCTTAAAATGGAAGCTGTTTCTGATTT^ ACGAGATCCCACATATTTCAGTGGGGTCATGATTGACAATTCTGTATGGGCACCATCCAGC TCAGGACATTTCTTCCCGTAGGCCAACTGAATTCTTTCCCCTGCACAAAAAGGTTTTACGC TGAGCAGATGCTGTGTCACAGTTGCGGTTATACATTTCTGATAGCCTCTGAATTCATCAGG

TCCATGAAACAGGAAAAAGTAGACTATCAGTCAGAAAGCCTGGCCTGTTCCCCTACCTTTT GCATTAATGGGTGGATGTAATTTGAAACAGTATGCCCTTGTGTCACTCAAGTCCAGCTAGT CCAATATCCCANGTTCAATATTTGAACATCAGCTGATGGAAAAAAATGGGCTTTGGAAAT GCTTTATGAATCTNTTAAATACCCTTNCATTTCATCACTCAAATTTCTGAACAGGAGTTGG NAAAAANGCTAANNNCCCCNTCCTAAACCCCTTTTTTTTTCCTAAC^GGGAAAAANAATA

GCAANCCCCAAGT(^TTCCCTGGGACCTTGTNNCCTGGTTGGGAAAGGGCNTTNGGTTTN CCCGGGCCCATTTGGGGTNGGGCCCAAAGGCCGGGGNAAACCTTGTTTTNAAAATAAACC CGGTGGGNTTGGGGGGGNAAAAAAAAAAT

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCTTTGTTCTGGAGNATGAGGACCTCANCCCCGGAGGCCCAGTGATGCCAGG GGCTCANGTGTTCCAGGGACTGAGCCGCAGTGGTCCCCAAACCCTGCGTGNGCTTGTGAC AAACAAAACCTGTCGGCTTCCTAGCATTTACTTTCTGCTTCAGAGGAAGGAAATGGGAAT GCTAATTTTTAAAAGACAACTGGATTTTGAGACTTTATCTTAAAATGGAAGCTGTTTCTGA

TTTTCACGAGATCCCACATATTTCAGTGGGGTCATGATTGACAATTCTGTATGGGCACCAT CCAGCTCAGGACATTTCTTCCCGTAGGCCAACTGAATTCTTTCCCCTGCACAAAAAGGTTT TACGCTGANCAGATGCTGTGTCACAGTTGCGGTTATACATTTCTGATAGCCTCTGAATTCA TCAGGTCCATGAAACAGGAAAAAGTAGACTATCAGTCAGAAAGCCTGGCCTGTTCCCCTA CCTTTTGCATTAATGGGTGGATGTAATTTGAAACAGTATGCCCTTGTGTCACTCAAGTCCA

GCTAGTCCAATATCCCAGGTTCAATATTTGAACATCAGCTGATGGAAAAAATGGGCTTTG GAAATGCTTTATGAATCTCTTAAATACCCTTCCATTTCATCACTTCAAATTTCTGAAACAG GAGTTGGGAAATAATGCTAAATTCCCNCTTTCTTAATCCCCTTTTTITTTπ^ AAAAAAANATAGTCAAACCCCCAAGTCNTTACCCTGGGACCTTGTANCCTGGTTNGGGAA AANGGGCTTTTGGGTTTTCCCGGGGCCCCAΛATTTGGGTNGGGCCCCAAANGGCNGGGGN

AAACCTTNTTTNAAAAATAAAAACCCNGGGGGGTTNGGGGGGAAAAAAAAAAAAAAAAA AAN

AAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGAATTCGGCACGAGGGGACAAGTTCTCTCAAGCTGCCAAAGTGGCAGAACTCGAGAAG CGCCTGACAGAGCTGGAAGCCACTGTACGCTGTGATCAGGATGCTCAGAATCCCCTTTCA GCAGGTCTGCAGGGAGCCTGCCTCATGGATACTGTAGAGCTGTTGCAGGCGAAGGTGGGC GCCCTGGACCTTGCAGTTTTGGACCAAGTGGAGGCTCGGTTACAGAGTGTGCTGGGAAAA GTGAATGAGATTGCCAAGCATAAAGCTTCTGTAGAGGATGCAGATACACAGAGCAAGGTG

CACCAGCTGTATGAAACCATACAGCGCTGGAGCCCCATCGCCGCCTCCCTTCCTGAGCTGG TACAGAGACTTGTCACCATCAAGCAGCTGCATGAACAAGCCATGCAGTTTGGTCAGCTTCT GACACACTTGGATACCACGCAGCAAATGATTGCTTGTTCCCTCAAGGACAATGCCACCCTC TTGACTCANGTGCAGACGACGATGTGTGAAAACCTGTCCACAATTGAGGGGAACTTTGCC AACATTGATGAAAGGATGAAGAAACTGGGAAAGTGAGCACCTTTGGGTGATGGANGACA

GGGGTAATTCCTTACCCCTTTGACTNCATTAATACCTTACACAGAGNTTNCCCNTTAATTG

NAACTTNTTGCATTCCANTTTGACCTTGGGGGCAAGGGCTTTNTTGCATTGGGGGGCTTAC

NCCCCCTTCNTTTNAAAANTAATGGGAAGCTTGGGGAAANTTAAAANGAAGGGNCTNCCC

CTTTAGGCC(^CANGGATTTAAGGACCTGGGCCCAAACCCAATGGCCCAGNTTTCTTGGC

CCAATAANTGGT

AAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GCCGCGCCGCCGTCGTCTCCAACGCCAGCGCCGCCTCTAGCTCGCCGAGCTCCAGCCGAA

GGAGAAGGGGGGTAAGTAAGGAGGTCTCTATACCATGGCTCGTACAAAGCAGACTGCCC GCAAATCGACCGGTGGTAAAGCACCGAGGAAGCAACTCGCTACAAAAGCCGCTCGCAAG AGTGCGCCCTCTACTGGAGGGGTGAAGAAACCTCATCGTTACAGGCCTGGTACTGTGGCA CTCCGTGAAATTAGACGTTATCAGAAGTCCACTGAACTTCTGATTCGCAAACTTCCCTTCC AGCGTCTGGTGCGGGAAATTGCTCAGGACTTCAAAACAGATCTGCGCTTCCAGAGTGCAG

CTATTGGTGCTTTGCAGGAGGCAAGTGAGGCCTATCTGGTTGGCCTTTTTGAAGACACCAA CCTGTGTGCTATCCATGCCAAACGTGTAACAATTATGCCAAAAGACATCCAGCTAGCACG CCGCATACGTGGAGAACGTGCTTAAGAATCCACTATGATGGGAAACATTTCATTCTTTAAA AAAAAAAAAAAAAAACTCGNGGGGGGGCCCGGTNCCCAATTCGCCCTATAGGGAGNNNN NNNAAANNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNHNNNNTS1NNW NNNNNISΠSINNΠSINNNNNNNNNNNN^

GCCCTACTGGAGCTNCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAAATTCGGCACGAGGAGGANNTTGNCNTCCTATNCNTATANNCNNNCTCANTAACC TTNTGNN(^ATTTAANGAAAGTNTTTGTGGTNTCTTCCCCATAAAGGAATTTACACAACCN

CCCNGGCCTGTGCCNGTGGATCATAAAAAAAGTGCCCNTTNNCCNNTNGAANGTANTTAA AAAAACCAAAGGGGGGGAAAAAACNNN(^AAGGCCNAAAGCCTTNNATTGGGGGCCACC CGCCNGGGTGGCNAAAATCCCCTNTGGCCGGGGCNTTTNTGGGCCNCTTACGGNGCNTAA AAAAGNCCCGAATNTGGNNCCCTGGTNAAGGTTTGNATTANGNTNTTGGAACCCTTNCCC TGNAANANACNCGGTTATCCNGGCCCCCGCNTGNNATTGGANTCNGTGCCTCCCATCCTG

GGAAGGGGGGTGTTTCATTTACCATTC(_^TCCNGGCCTTATTTGAGGGAAANGCCCCNNG GNAAAATGNTTTNOSfATNTTAAACACATTTTTTTATAAGGGCCCCCGCATT(_MSrGAGGG TTTTAAAGGGGANTANCTTGNTTTTGCCCTGNGNTGGGNNTTGGNCNTTACTAAAAAGCTT CCAAGGGCCCCCCTTTTTTGACCCCCCCTTTTTTCTTTTGGGCNANAANGNNCAAAANAG CTTTTAAAAAAC(^GGGGGGAAGGGGGGGAACC(-^TNGNNTTTTGGGGGGGTNTTAAAπ

GNCCCCNCCCCCNCCCAAGGNGGTGGTNGGGGGNTTTGCCNNNNACCGGNCCCCCCNCNN TTTAAAAANNNANNAAGGGGGGCCNTTTTGGGGGNCCNAAAAN^

AAAANNNNNNNNNNNNNNAAAAAANNGNNNCNOST^ NNNCT

GCCCTATANNGAGNNGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGATTGCAGCAAATCATGAAAGGTAACTTCAGTGCATTNATGC AAAAGGAGATATTTGAACAGCCAGAATCCGTTTTCAATACCATGAGAGGTCGAGTGAATT

TTGAGACCAACACAGTGCTCCTGGGTGGCTTGAAAGACCACTTGAAGGAGATCAGACGAT GCCGACGGCTCATTGTGATTGGCTGTGGGACCAGCTACCACGCCGCTGNGGCCACGCGGC AAGTTTTGGANGAACTGACCGAGCTCCCCGTGATGGTTGAACTTGCTAGTGATTTTCTGGA CAGGAACACACCTGTGTTCAGGGATGACGTTTGCTTTTTCATAAGCCAGTCAGGGGAGAC TGCAGACACCCTCCTGGCACTGCGCTACTGCAAGGACCGCCNAGCTCTGACCGTGGGCGT

CACCAACACCGTGGGCAGCTCCATCTCCCGCGAGACGGACTGCGGCGTCCACATCAACGC AGGGCCGGAGATCGGTGTGGCCAGCACCAANGCTTACACCAGTGCAGTTCATCTCCTTGG NGATGTITGGTTTGATGATGTCTTGAAGACCGCATTTCACTGCCNAACAGAAANGGCGAG AAGATCAATNCATTGGCCCTGGAATTCTTCTACCC(^AGTCTTATTCNAANGAAGGTGCCT NTCCC^TTGGTATTGAAGAANATTCCANCNAANCNTGGNCCCTTGGTNNCNTNTNCACCA CCAAAAGGTTCAN(^TITTTGGTCCATTGGGGGCGNAAGGCTNACAANNTATNCCCACAT CGGCCTGGNAAAAGGAAGCCCCCTTGAAAAATTTAATNGAAAATNNNCCCTATTTGCCCT TTAAAAANGGCATTCCTNGGNTTNGNANAAANTTAAAACNNCGGGCCCCCCTTGNNCCTT NNTTTNNATNAAGCCCANAGCCTTC

AAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GANTTCGGCACGAGGTTGGCAATTACCAATTACCTGTGGTATTGGGAGAAAGACTCTTTG AAGAAGCCCTTGGANTGGAAGGGAAATCCTTCNATCCNTTCTAAANGNAANNAANCCNN

GGTGGTCNTTGGAANGNCNGNNGNTNAANCTNAAACNN(^ATACTTTGGCCNCCTNNNGC NAAAANCNNACTNATGNGAAAAGACCCTNNTGCNNGCNAANANTGAGGGCCGGANGAN AANGGGACCACCGAAGATGGCNTNCCNACACCATGGNCCTNGGTTTGGGTGGACNTCCCA AATTGGTGAATGACACAGGAGAGCCTGGCGTGCTCTGGNGCATGTGGGTCACACAAGAGA CCACACAACATGAGCGANTGAGCTGNGCTNNGCTGNGATTACCTCTCTTTCACTGTGANA

TACCCCTTACNTCTCTTTCTCNACTGANATTGAACTNTTTTGNNCACGTNATGTGTTAATAT GGGNCATCTTANNGC(-^TATATAGGGNNNAGACTTTNTTATTTTATAATATAAAAAATTG GGCATTTTAGAAAAAAAAAAAAAAAAAACNTCCGGGGGGGGGGCCGCCCCCCAATNTNC CCTCTTTTNGNGGGNNNTTTATNNNN^^ TTNNNC<_ NNNNNNNNNNNNNTTTNN^

NNNNNNNNISINNNNNCNNNNNNNNNNNNNC^^ NNNNNNNNNNNNNNI^M^NNTSINM NNNNNNNNNNNNNNNNNNNNNNNTNNN^ NNNNNNNNTNNNNCT

AAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GANTTCGGCACGAGGTTGGCAATTACCAATTACCTGTGGTATTGGGAGAAAGACTCTTTG

AAGAAGCCCTTGGANTGGAAGGGAAATCCTTCNATCCNTTCTAAANGNAANNAANCCNN GGTGGTCNTTGGAANGNCNGNNGNTNAANCTNAAACNNCNATACTTTGGCCNCCTNNNGC

NAAAANCNNACTNATGNGAAAAGACCCTNNTGCNNGCNAANANTGAGGGCCGGANGAN AANGGGACCACCGAAGATGGCNTNCCNACACCATGGNCCTNGGTTTGGGTGGACNTCCCA AATTGGTGAATGACACAGGAGAGCCTGGCGTGCTCTGGNGCATGTGGGTCACACAAGAGA CCACACAACATGAGCGANTGAGCTGNGCTNNGCTGNGATTACCTCTCTTTCACTGTGANA TACCCCTTAOSITCTCTTTCTC^A

GGGNCATCTTANNGC(^TATATAGGGNNNAGACTTTNTTATTTTATAATATAAAAAATTG GGCATTTTAGAAAAAAAAAAAAAAAAAACNTCCGGGGGGGGGGCCGCCCCCCAATNTNC CCTCTTT GNGGGNNNTTTATNNNNNNNNNNNNNNN^ TTNNNCCNNINNNNNNNNNNNNTTTNN^ NNNNNNNNNNNNNNCNN^^

NTSINNNNNNTNINNNNN^ NNNNNNNNNTSπSENNNNNNNNNNNNTNNN^ NNNNNNNNTNNNNCT

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCTGGAGCCCTCCGTGATGTCTCTGAGGAGTTGAGCCGCCAGC TGGAAGACATCCTCAGTACATACTGCGTGGACAACAGTCAAGGGGGCCCAGGTGAGGATG TGGCACAGGGTGAGCCTGCTGAACCCGAAGATGCAGAGAAGTCCCGGACCTATGCCTCAA GGAATGGGGAGCCTGAGCCAGAGACTCCAGTAGTCAATGGTGAGAAGGAAATCTCCAAG

GGGGAGCCGGGCCCGGACGAGATCCGGACCAGTGATGAAGTCGTAGACCGAGACCACCG AAGGCCACAGGANAAGAAAAAAGCCAAGGGTCTGGGAAAGGANATCACCTGCCCCACTT TAACTACCTNTTAAAGCCTATAGTGGTTGGCANGGAAGGGGACTTGCCAAANCCCAGTTT GGNGGGGCAGGTTACAGTCTTCAAAANCCAAGTTTACTTGNTNGTGAAGCAAGGGGGCCC CACTTGGCCAGGGTAGAACTTTTGTTTTAANTTAACCGTCCGTTTGTANCCTTCCAGGCCA

GGTTGAGGGGGGGTCCCATTGCTTCCTTGACCAAATNTTTTAAATACTTACAGTGGNTTTG GTGGGTNTGNTTTCCAAAGCAANCCCAGGTTCTNGGTGCTGNCCCCNCCANCCAGGGNCC TGGNCCAAAAAAAAAGGGGNCCTTTCCTGAATGAAGGCCANTTαSfTTTCTTCNTGGGGCA GGGTTTNTTGNCCCTTGAACCTAATTTTTTGGACCCAAAAACTNGGGTGGGGTTTTT^ AAGGTAACNTTTTCCTTTANGGGAACCCCCCGGGGGGGAAGGCTTTNTTTGAAAANAAAC TTTGGGTTNAGGGGTTTTGGCCC(^TTTAAAAACTTT

TTNAACAAAACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGGTCCCCTCCCCCCTTGCCCCTCCAGAGACTGATGCTGGAGCGTGAGTTGATTTT CTTGGCTCGATCTGTCCTTTCTGAGCTCTAGTCATAGCACTTTGCAGAGCATCCTGGGCAC CCTGGTGGTGCAGCTGCAGCCTGCGGCGGTCCTTAGCCCCAGGGTCTTTGTTTCACAAAAC CCTCTGGTACTGTTGTGGTTTTGTATTCTTCCAGTGTTCTCTCTCTCTGTCTCTCCTAACTAT TCAAAAGTATCTTTGCTCTTTTGCCCTTTCCTTTGACCTTCTGTTCTAATCCTGCTTTGGAAT

TAGCCGGTGTGGGGAGAGGTACACCATGTCGGANAGAANAAAGAGTGCCTGTTACTGGA AGTGTTTCCTATTCACGTTTATTTTGCTCAGTTCTTTTTATTTATGCCCTTGGGGCCCAGGT ACTTGGGCAGCCAGCTAACCTCCTGGCTAGNGAAGGAGACCAGGCNCAAAGTGAACACC AAGGAAAGGTCGNGTGTTTNTANAACTCCAGCAGANACCAAGCCCTGCTGCAAATTTGCA AGGCCANACCAAAGGGCCACACAGTTGCTCATAAGNGTAAATATTTTGNNCAGNGAATAA

ATGAATGGTTTAAAAGGAAAAAAAAAAAAAAAAAAAACCTNNGGGGGGGGCCCGGGNN CCAAATTαSTCCCTTAAANGGGGN^ NNNNNlSπsπSlTSINNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNrø NNNNNNNNNNNNINNNNNNNNNNNNNNNNNN^

TTGAAAACAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGNNTNAACCTCNAGNANTTNAGCGCTCCNGCCCCAGGCTANTCAACACAGCN NGGGTCTCTCCTCCTGCTGNNGNTCTCTGCCCTCCACATCCTCATTTCTTATCCTGCTTTNC

GGGGCCACTTTGGACAAGTCCTGGTGGACTCTCCCCGGNAAGGANNCCCTGAATCTCTGG TACGACTGCACANGGAATAGTGACAACAAANCGTGGGCCTGNANAAACGTCAGANAAAA CGGCTTGGNTGAAGGNAGTNCAAGATCCTCATGGNGCTTTCCCTCATNCTNTGNTGCNTGT CCTTCATCCTGTTNATGTTCCCANCTCTACACCATGCTGGCGAGGAGGGCCTATTNTATNC CACTGGCTTNTTGCCANNATTNG(^CCANCCNTGGCAGTGTTTACCGGGNGCNCTNNTNT

ACCCCATTTCATGCCCGAAANAAAATTNCTGGCNNNNCCCGCCCGTAGGGGGGGCAANCN TNTGGGTAANTGGCTTCCCNCCNTGGCCCTTGGGGNGGNCCCTTNNNCCCNTTNGCCCCTG GCCNAG(-^GGNAATTAATCTAANNNTCCCCACTNNCCGNNAAACCGGGNAATTNNAGGG GNTNCCCCCTCCCCTTTGGNTTTNCCCAANACNNAATTTCNNCGCCCCCTATNCNTCNTNA NCCCCNGAAAANCCCCCAANCCCTTTTNTTCCTTTTTTTNAATT^^

NAATTTGTNNNNCCCCCCCGGAAAAAAAAAANAAAAAAAAANNTTTNNGGGGGGGOSΓCC C<^CCNCCCTTTNTCCCCTTTTNTGGGGGGGCGTOSITTAAANAACNTTNCCNCNGNNNTG NCGGCCAACTCNCNAATTTNATTTATTTTATCCTNCAAATCTTTANACCTCTNCCTATCATC CCNCTGTCATCNCTNANNCIWT(^TNCGCCTCTNTΣWTNNTNNCANNTANTANACATTAC TTNNTGTTATTTCNNTTTANTCNACCNTNNTCNNCG

TNNNACAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCTTCGGTAGCGACCGCCTCTCTACGCGGGTGTGAGCTT CGCCAGCCCCTCCCCCAGGAGACCGTTGCAGTCGGCCAGCCCCTGCTCCTTGGTAACCATG

TGTGACCGAAAGGCCGTAATCAAGAATGCCGATATGTCGGAGGAGATGCAACAGGACTC GGTGGAGTGTGCTACTCAGGCATTGGAAAAGTATAATATAGAGAAGGACATTGCGGCCCA TATCAAGAAGGAGTTTGACAAGAAGTACAACCCCACCTGGCACTGCATCGTGGGGAGGAA CTTCGGTAGTTATGTGACACATGAAACCAAACACTTCATCTACTTCTACCTGGGCCAAGTG GCCATTCTCCTGTTCAAATCTGGTTAAAAGCATGGACTGTGCCACACACCCAGTGATCCAT

CCAAAAACAAGGACTGCAGCCTAAATTCCAAATACCAGAGACTGAAGTCTTCAGCCTTGC CTAAGGGAACATCTNCATCTTTGAACCTTTGNTGNGTTTTGTACAGGGCATTCTCTGTACT AGTTTGNGGGTATAAAGCAATTAGTAAAACAGCTTACATTTGGATTTATTTTCTATTCCAT ACCITI NTGNCCCATTGTTTTTTCTNTTCAAAATCCATTCCTTTAA^ TGGAAGTGGGCGTTNAAAAAAAAAAAAAAAAAAAAATTTGGGGGGGGGGNCCCGGGNCC

CCAATTNNCCCTTNANNGNGNNNNNTTNT^ NNNNNr>ns[NNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGCTAGATTGGCCTTTNGACGATGGAGCGCCACCCCCTAANCNNA TTGNATATGATNGGCTANNCCTACTAAAANCCANNTTNCGTGAANAACCNGGTTGCTGTG NTGNAGTGCNTTGNGTNGCANGATTGGNAAGGG(^CCTGTGCTACTTGCNCTTGCTTTGAT

TGAATGTGGAATGAAGTACGAGGATGCAGTTNAGTTTATAAGACNNAAGANAANGGGAG CNTTCNNTTNCANAOSfNCTGNTTTACCTGGANAAATACCGACCTATGATGCNATTNCTCTT CANAGATACCANCGGGCATTGCTGNGTNCAGGTAAAATGAAGTGTATACGAAGGCTGACT TGATTGTAGCATTTACAGGGAACTCTTGGTACCTGGAAATGNGAATCTGGAATCTTANCTG TNTCATNAAAGTANTGATGGATTCNGTACTCCTCANCCACTCTNCTAATGATTGTAAAAAA

GCAAACACNANTCCCTNTATAACGNGAATNAAATGTNTAAGAAANGANNATGAGAANGA TTATAGGGGATTAATTNACTGANAGATGATTNTTGCTTCTAGNGCNGGAGTTTGAATTTCT GNCAGGATTGAATTTATTTCAAAANCTGCTGTCTTTTTTAACTTTCTCAAAATAGGTNTCTA ANGAAANCCANCAGAACATGATCCTTTCAAAAGCCTCTGTTTGGGGAGCACACTTTCCTT

TTTNNNNNNNNANAAOSITTTTTAANNCCCTNGANCCCTNTTNTNA^

GNAAANAATNAAGGTTTTTNGNGNNNNNNNNNNNNNNNN^

GGGGGGGNCNNNCCCCCN

GCCTATNTGGAGCTNCATCNCNGTGGCGGCCGCTCTAGAACTAAGTGGATCCCCCGGGCT GCAGGAAATTCGGCACGAGGTTTCTTGGTCCATCAACCTAGCCTCTAAGTGGTGTGAGCG GCCTGAGTGGGTGCACTTGGACAGCCGGCCTTTTGCCTCCCTGAGCCGTGACTCAGGGGCC GCCTGGGTCTGGGCATCGCTCTGCACTCTCCCTGCTATGCCCAGGTACGGCGGGCACACCT GGGATATGGCCAGAAACTAGTCTGTCTTGTGCTGGCCATGGGGCTGCTGGGCCCCCTGAA

CTGGCTGGGCTACCCCCCTCAGATCAGCCTTTTCTACATCTTCAATTTCCTCAAGTACACCC TCTGGCCATGCCTGGTCCTGGCCCTCGTACCCTGGCTGGTGCACATGTTCAGTGCCCAGGA AGCACCACCCATCCGCTCTTCTGACTCTGGTGCCTNCTGCACCCACCTNCCCTNACAAAGC CCATGCTCTGTGACCTCCACCCTTGGGAGGCAAGNTCCGTCCACTTCCAGCCCCCAACAAC CCTGCTCATGTTGAATTTTCTACTTCTNCCACCACCTGGTCACAAGCCCCAAAGAGGGGCC

TTTTCTCTTCCAGGAAGGNCCTTCTGGCTTTCCTTCCAAATCCCCAAAGAACCAACGCACN CTNCAGAACAACGGATTTCTGTAACACTGGGAANGGGCTCGGAACAAACCCCAATAAAGC CCTTTCACACCCNCCCNNAAAAAAAAAAAAAAAAACAAAANNNCCCCCGGGGGGGGGGN GGNANANAAATTNNCCCCTAAAANNANNGNNCCCTNAAANN^ CCCCCCCCCCCCCCCCNCCCCCNNNGNNNISΠSINN^

NTAGTISΠNINNNNNNNNNNNN^ NNNNNNNNANNCCCCTTTNT

NCNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGNCCCACCTGNACNTGNAGGCCANNCACTCNAANATCCTCA NGNACNTNNAGNCNGGCNCATACNNCCGGTGNNTNNTNGTNAAAATNNTCCTCATNCTGA TTGCNNNCTTNATNATCTTTGAGNACTNCCTTGCCTGAACCCTNNNNACTCTNANGCAATN CGTGGGGGTNNGGAANCNTNANNGNAGAGCNGGNNNCCATANCTGCNNCNGANCCTGAN σSfGGGGGNTCCGNGAGAANGGCCCCNTTTCCTTGTNACTGCTAATACATGACCNCTGNCC

TCTGTCCNCCACTCCTTGCCTCTGGCCACCCATCCCTCACCTGACCACCCTACNGCCCATG AAACNCAC^CGGANNNNGATTNNGACNCTGNTNTNAAGTGGTTNNAANGGATCANAAGC CAACTGATGNNCTNNNNGGNNANANTGTCTNTACCTNGAGATNTTTATAAACCCTCCCNA ACCTGT(^CAGACGGGAACTTTGGCTACANAGNGGAGATGATGCCTTTCCCCACATTNTT GANATNAATGATANGANGGGAAACNGCCCACATGNACCAAATNTTCCCATCNNGGTTAG

AATNNGANACTATTATTCCTCTCTTTACCCACATGAGGCACCGGANCCCCTGAGCCCCTNN GGAGGGACTGCACAANCCCCANAATTNGGGCTGGCAAAATGAACTTTTAATTCNGGACGA AACGTGCCNGTCNCCCCTGTTTTTGTTCCCAAGTTACGGGCCTTGACTGGNCAGGCCTTCN ATTTNCTGGGNCATGGNAAAAAAATTTNCCCCTTTGGGGGGGGGGNCCCNGAANCCCCAA NAAACGCCCNTATAAAAACNN !NNNNNNNNTTTAAGNNGNNNNNNT^

NTNTTNCCC GCCNATANGGAGNCGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGNANAAATTGNNAANGCTGNTGAGCTCTAACAGCACAGACCTNCCACTGANCATCG NGTGCTTCATGAATGACAAAGAACGTTCTTGGAAAGANNANCAGGGCCCANTTGGAAAA NCTTNGGNCTGNCTANNTGAANANAATAAAANTNCCCNTTNNTTTGTGGANGGACCAANN NCACTTNAANNAAAAGGANGNNANGNTNGNCAAAANACTNGANGNC( NNNCCNAANTCC

CACCCGNAAAGAAAAAAAN(_^CCAATTCTTTGGAAAAGAANNCCNNNCCACC<-MNNAN^ CCAAANAAGCCNTGGCCCAAGGGTGNGCCCCTNCNTTGC ATCCWTTTCCCCACATTTAA AGGTATAGANAATTTTGTCACTGNTGΑSRCATTTCTTTTCCANTATCTNTGGNNNNNGGANC CCGATTTCAACAAATNCNCTANANGGGTTCCATGAGAATGTGNNTATATANAANCCCACC TGTGCCTTTTTTCCACAAAATTTTCTCGCTTCTCNTAAAANNGGGGCCCTTTTTGNGCTCGG

NNNCCTNTTTATTNCTTGTCCNTCAAGGAGGTTNC^CNATTNTNCGANTCNCNAAATAATG NNCCCCTCTNTANTTTANAAAANATGTTTCCACCCCCAAGGNNGGNGGGAACNANNTCTN CCTCGGNGNAGANCTCTAAAGNAGCTGACGGNGGATTCCCCCCNGGNGTTNTNTTTCCNT CTTTTNNTTACNNGTNTATCGGNNGGGGGAANAATACCCCCCCNGCCCGANNAACAAACG TGGGTTTΓCΓΓΓNTTTTNCCCTCCNTTGGTCNTTTNTGTAA

ANAAATNTCCCTGCGGGGTCATAAAATTTTCATCNCNNTANNNNCACAANGAATNCATGT TTCCOSINCCCC^CCCGTTCGNAAACCCAGATTGGTNNTTATAANCCNTCCGNGNNCGTGC

CCCCG

GCCNATANGGAGNCGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGNANAAATTGNNAANGCTGNTGAGCTCTAACAGCACAGACCTNCCACTGANCATCG NGTGCTTCATGAATGACAAAGAACGTTCTTGGAAAGANNANCAGGGCCCANTTGGAAAA NCTTNGGNCTGNCTANNTGAANANAATAAAANTNCCCNTTNNTTTGTGGANGGACCAANN NCACTTNAANNAAAAGGANGNNANGNTNGNCAAAANACTNGANGNCCNNNCCNAANTCC

CACCCGNAAAGAAAAAAAN(^CCAATTCTTTGGAAAAGAANNCCNNNCCACCCNNNANN CCAAANAAGCCNTGGCCCAAGGGTGNGCCCCTNCNTTGCNATC(^TTTCCCCACATTTAA AGGTATAGANAATTTTGTCACTGNTGCNCATTTCTTTTCCANTATCTNTGGNNNNNGGANC CCGATTTCAACAAATNCNCTANANGGGTTCCATGAGAATGTGNNTATATANAANCCCACC TGTGCCTTTTTTCCACAAAATTTTCTCGCTTCTCNTAAAANNGGGGCCCTTTTTGNGCTCGG

NNNCCTNTTTATTNCTTGTCCNTCAAGGAGGTTNCNCNATTNTNCGANTCNαsfAAATAATG NNCCCCTCTNTANTTTANAAAANATGTTTCCACCCCCAAGGNNGGNGGGAACNANNTCTN CCTCGGNGNAGANCTCTAAAGNAGCTGACGGNGGATTCCCCCCNGGNGTTNTNTTTCCNT CTTTTNNTTAC3SfNGTNTATCGGNNGGGGGAANAATACCCCCCCNGCCCGANNAACAAACG TGGGTTTTCTTTNTTTTNCCCTCCN^

ANAAATNTCCCTGCGGGGTCATAAAATTTTCATCNCNNTANNNNCACAANGAATNCATGT TTCCCNNCCCCNCCCGTTCGNAAACCCAGATTGGTNNTTATAANCCNTCCGNGNNCGTGC CCCCG

AAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCCCGTCCCAGCTCCAGCTGGTGACCAGAAGGATGTGGATGCT TCAGAAAAGAAGGTCCCAGAACAGACCCCTGAGCCTCCCCAGCTGGATTCACAGCACCTG TGATCATTCCAGGACCCCAACACTCAGGGTTCCTCCCAAGGCTGATGGGAGGGGGGTGGA GTGTCACAATCAACCTCCTCTGGGGACCCGGCCACACTTGTGGCCTCCTGTGGGAGGGGG

AACAGGCTGGCTGTTTCCTTCTCATACTGCTGCCCAGGCCCTGTATCTGCCACCTCAGTCTC CACAGCCTTCCAGTCTGNGGTCCCCTCTTTCTGGTCCCCTCCAAGGGACTTGCCTTNTCGTA TCCAGTTGAATGCTCACTGGCCTTAACTTTCATTGANGGAAGCCCCCTTNTTTCAAGGAAG GGTCTGCTCACACCTGCCTTTNTAAGTTGGTTTGGCCTTGACNCCAAGGTGGGGGCCATTC AAGATTCCGGATTCCCACAAGTTGGTGAAATCCTGCCTGGTGGTTTTGGGCCCAACTTTCC

GTTGGTCTGGNGGGGCTTTAANGGGCCCCTTAAACACCTTTTTTTTAAATTTTGGGG TGGGCNATGCCCTNAAANAAAGNGGCTTNCCCCCCAAGNTGGGGTGGNAAGGGCCAAAA AAAAANCCTTTGGATTNGTTNAAANAANTTTTGANNCCCAGGAANCCCTTGACTTTTCCTG GACCCCTNGGNTTTCAAACCATTTTNAANCCCCCTTTCCTTGAAGGGAAGGGGTTCCTAAA CCCCTTTTNTTTCCAAATTCCCAAAAANGGAANAAAANAAATTGGNCCCCCCCCGGANGG

AATAAGGGTTNCCCACCCCCTTAAACCNTTTTNGGGGTTT^ CTTTTTTTTNT TTNAACACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGAGTANCAGGAGTGAAATCAAAGGATTTTATGATCCACC AAGAAGATTGCTGGGCCAGCGACCAGGACCATATGATAGACCAATAGGAGGAAGAGGGG GTTATTATGGAGCTGGGCGTGGAAGTATGTATGACAGAATGCGACGAGGAGGTGATGGAT ATGATGGTGGTATGTGTATCTAATGAACAAAGGTTCTGTTGTCATTTTCTTAATGTTCCTGA

CACTTTGTCAAGAAATACAGAAATGGCAGTAATTTCAGTACCTACTAGGTTTAATAAATCT GTTCATACAAATGTGGATTCCCATGGGCAGCTATGGGACTTGATTGATGCATGTATTGGCA CCTAGTTTACCTACACAAAAATTTTTAAGAGATTGCCATGTTTTGACCTTTTCTGT^ TCAGGATAAAAATTTTTATGTCTAAATGTGTGCTTTTCATACAAGTGTTAACTGCTTTTT^ ATATACACTAAAATGGGGTGTTGGAAAACTTGGTTGGAGGGGTTGCAAACTTGTAACAAT

ATAAGTTAACCATAGTGCTTGNCANAAGATACATTTTTATAAACTAGATAATAAAAGTTAT CTCTTGAAAGCTTATTCATGNATTTCTCCTTAAATTACACAGGTTATGGAGGTTTTGATGA CTATGGNGGCTATAATAATTATTGGCTTTTGGAAAANGATGGCTTTTGGATGACCCAAATG GAAAAATGGGAAAANGTTTGGGAAGGACCTTGGTTTTTGGGGGGAACTTGGGGGAATCCA AAGTTT(^GGGTTTTTCATGGGGGGGGCANTTTTGNACCATAAGAAAAAGGACTGGNCNT

TTTTCNGGCCACTGGNAAAAGGAAATTGGGNAAANTTTCTTTTTCNCC

NACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGAGTAGCAGGAGTGAAATCAAAGGATTTTATGATCCACCAAGA

AGATTGCTGGGCCAGCGACCAGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTA TTATGGAGCTGGGCGTGGAAGTATGTATGACAGAATGCGACGAGGAGGTGATGGATATGA TGGTGGTATGTGTATCTAATGAACAAAGGTTCTGTTGTCATTTTCTTAATGTTCCTGACACT TTGTCAAGAAATACAGAAATGGCAGTAATTTCAGTACCTACTAGGTTTAATAAATCTGTTC ATACAAATGTGGATTCCCATGGGCAGCTATGGGACTTGATTGATGCATGTATTGGCACCTA

GTTTACCTACACAAAAATTTTTAAGAGATTGCCATGTT^ GATAAAAATTTTTATGTCTAAATGTGTGCTTTTCATACAAGTGTTAACTGCTTTTΠ ACACTAAAATGGGTGGTTGAAAACTTGGTTGGAGGGGTTGCAAACTTGTAACAATATAAG TTAACCATAGTGCTTGTCAAAAGATCCATTTTTATAAACTAGATAATAAAAGTTTATTTNT TTGAAAGCCTTATTCATGGANTTTCTCCCΓΓAAAATAACNCAGGTTTATGNGGGNTTTGAA

GACCTATGGGGGGCTATAAAAAATTATGGGTNTGGGAAANGAAGGGNTTTGATGACCNC AAATGGANAAAATGGGAAAAGGTTTGGGAAGGACCATGGGTTTTTGGGGGAACCTGGGG NAATCAAANTTCNGGTTTTTNAATGGGGGGCCATTTTGGNCCATAAAGAAAAGGGACTGG CCNTTTTNGGGCCCCCTGGGAAAAAGGAAATTGGGTAAΛTTTNTTTNTCCNCCCCTTAAA

TTNNNAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCCCCATTCCTGTGGCCCAGGGGCCCAGCTTCCAGTTCGGC AGTGTCAGAAGTGACTTGTGGCTCTGCCTTGGTTGTGAGATGAGTACATTCCAAAGGAGC AGCCACGGGGAGGGGGCAGGCTCAGCGATCCCTTGGAGGCTCAGAGCAGCTGGCCTGAG

CTCCAGCTCGCGTCCAACGGAAGCTCGCGCCCCTCAGAAACGACCCTGGCCAATGTCACC GCAGAGCCGAGGCGGTGTTGTCAGGGCTAATGTGAAATCTCTTCCCGTGGCGCCGATCCT CCGGCTCTGCAGCGCCAGCTCGGACAGATTGAGGTCTCTGTGGCTTTGGTGACCCTGCTTA AGCATTCCCACCGTGTCCCAGCTCTGCTCTCTGCCTGCCTCCCACTGCAGCCCCCCCCTCAC CTGGCTTGGGGAGGGGGGCAGTGCCCCAAGGCTAGGGGCTTTTGCTCAAGAAAAGATGTC

AGGCTTTCTGGGGTCGTCAGGCTTTGAGCTCTACCGGGGTCCAACTGACCTGGGATACCAG GTGTGCCCAGAANATGCACCTCATNCCGTGCCTTNAGGAANGGCTAAGGAACAATTTTGG TAATTGGATTAACTTTACCTCAGTTAACTCCCNTTGGGAAAACCTAACCCANTTTTTAACT TTCTGGCCTAAAAATGANTGTATTGNNTANGGAAAANTGAANCTTTTAATTGCTTCCCAAA AAGGGGCCITGGTTTTCTTCTGGANTTAAAATTTTTTTTTNTAAGGGGAAN^

NNNr^NNNNCNCTCNNGGGNCCCCNGNNGGGGGGCNGGGGGGNCCCAAAAAGGNNCCCC ANGGGGCCCCCAAAAAGNGTTTTTTNNNGGGNGAAAAANGGGGAAA

NNCGGNCGNCGATTNAGCGTGNNNTGNNNTNTNNNNNCCNNNNCTCN(^CCCTCTTCTCC

TNACCCGCCACATGCACNTCCCCCCCCANGGGGNGNNAAGAGAATATGGNCCNNTNTNTT GGAGNNCAACTGGAGCTNCACGCNNGAGGCAGGCCGCTNTAAAACTAGTNTATNCCANN NNTCCTGCTGNTATCTCAATC(^CNTTGAATTTTTNTNCNNCTTCGCACANNTG

TTCANNNNNGGNCOSπSlNTTTNNGTNCNATAATTNTTNA NNTNGCTCGTGGACCATNGNAATCCTGNTNATNGTNNNTACAATTNNTOSFTCTTNGGGGT NATATCTTNNAGCAGATCGTTTNCAANANANCTNANO^ACGNGAC SINTNTCTATCNCNAN

ANTNGNNTNNANTNNCTAGCCGGNCGANATNTNATCANGNTTNGCNNNNNANGNTGNNN NANTNNTNNTNCM^NNNGTNTNAGCTTNTN^ TGTANAACTNTSΠSINNNNNCNNNTCTNNTACGANNATCANCANTANNNCGANTNC^

NANNTNNCNNNANNΑSTOSINTCT^

NTOSLNNNCANCAAANTTANGTNANGTCTNGΑSINNANTAATTNTCCNANAGACACNTNTTN GATCTTTTTCGTNATGCTATNTGCGANN^ TTTG(^GGOSRGNNNNNACNGCAATCTTTNNNTNNANNNTNNGT^ TATCATNCCNNNCNATTNTNNATNANTGAGGTGNCGNTANGTAANTNGCGGGNTTTATCN

TCGISINNTNNA:NINTNGTNNTGNACNGN

NANNCNNNNANTANT INTCNANNNNNNTNTTCNNCATNGNACGNCGNTNNACCNTATAG NTAATTTTANNTNNNNTAGGNCGNGGGNNNNATAANANTTNNTAGTNANNCNTTNCAGT^ NNTANCNGNCNANCGGNATGAAGIWNATCANATNCTNTNTAANNAGTGCAANCANNCNN NNGGANNNAGCNNAGNTNTATNCTCNAGNNNANNGNANCANCNCNTCAGTNTAANNAGA

TGNANCAGCTGTGAGNTGAGGCNGNGCGNTGNGTACAGAGNTNTNTGTATAGAANCNCA N(^TGTATGNAGTCTGAGANNATOSΠS[ANATGNNGNNCNTGTNTCTCNNTATNNAGACTAG ANTNNNACTNTCTGAGANGACATCTATGNTNGANNNANANANANACNCGANANANATNC GAGATNNGATATGACGNTTNTNTNTNCOSFACNNATGTATNTATNCNGNNTCTCANANGAG ATGA(^CA(^AΑSFCTNNCTCATACTTNTCTNTNCGTNCNNNTGTCTANNNTATGTGAAGTA

TACACTAACGTCNTACATGTNANATGATNTACNAGCNNGNGGANNNANTGACNAGTGTG AC-NAGACNACNOSITNACTAGNGTCGATAGNCNANATNNNGNNATANNNTCGTTNTCGCG TATNAGCGCG

CCGCCNCCNCCTCNTNGANNTNNTTNN^

NNNCCTCTCATCNNCTNTGGNNGNCGGNNGCTC GNNGNTNTNNNTNCNNNNCNGGGGG NGGTNNANGTGTNTNGTTNNNNNNNNNTTNNAGCCCNATAGTGGAAGTCGTATN^ NGGCAGTNCNCTCTNAANCTAGNGGGATCCCCCGGACTGNCTNGANTNTNCCGCCNCAGG NNCTCTNNNTCCCTNCNCTCCTTAN^

TNTNTNNCCNCCTA(_^GCCNANNC3SINCTCCCCCαWTNTCCCNN^

NCCTCNTSTTTCTCTCCTCCNCCCNANCOSfCCCTCNCCNNNNCTCTCGACNCNTNGTNGCNCT NGTGNTCAGANNCNTGTCCOWTNCCCCNNCTCCAGNGCTCTTCCNNNNTCNAGNTCNCC CGNTCTαSINNTTCNAGTCCNCTNGACNNTTGT^WACNCCNCNCTNGTCCNNCTCCCNNTTA GACNCCNGCNCCCTNTCGCTCasrCN(^GNNTNTTCCNNNTACTTTCCCNCTCCNNNCACNC

GNGTNTCCGCCNTCTNNCCCCCTC<^TCTANAGNCNCNCCTGNTCCTNNATNOSINTNNCTN CNTATNCCTNNACTCNNNNTNTCCCNCAGGNNCNTGTNCCCGTGNCGCCNCTNCCNCCTC ANNTCTNTCNNCC(^TCACCNGCTNCNTCCCNAasrNGAGCCCTCCTNGTTNTGNNCCNCN AGNNCGGNTTCCCNNGACGNCNCTNTCCCNCATTTTNaSfACCNGTNNCCTCGGNACNCCN CACTCCCCGCGCNNTNCCTCNACNNCC^σSINGNANCCACTNCTATNCCTNNCGACTCCAC

NGCTTNCTGTCGNNTTGACCCCCCTNCNACGN<^TCCNTAGCNCCCCTCTTGNNTTNCNGA TCCNCNNNNNGTCCNGATGNCTTCCNGTTCCCCGTTNNGACTNCCGGAGNTTAGNCANTN TTTGTGNCCTACNNTTCCCTTGATCNCCCGCTNNNGCCNCNGGNGTCCCTCGANCGNCACC NTGGANGNN(^GCNNTNTGNCGGCNNCCGNCTCAGACCGTNNCTGAANNTNTNCTCTNCC TTNANCGACNATCACGACCACCNGNNOSINTTCNCGNCACGCNTCGNCNTNACCTNNCNCC

NNCTACCGTAGCTCCCNNAGCTCCNCNTACCTNTGTTNATNNACCACANACGNTGCTNCG CAGTATCNCCCCNCGTAGTNCCNACGCNNNTNTCCCAGCTCTGTNAGGGTCTCTGCGTATC AGCTCCCGCTGGTCGGNACTCCCCNATNTCTCTCTCTNCTTNTNNCCGCCACTTAAANGAG NTACNAATNGATTACNNNATNTCACGTTACTANCTCGNNGCACGNGCNGCCCTATGCTCN GNNANNCCCTCTACNAATGGANGTANCCTNCNCNAAGGNATCTTTCGNATGGANCNACCG

NAC(^TNNGTACCGCGCCTTAGGNTGGCGCTCACNCTTGNTANNTNCGNNTCTTCGCTCTT NNCHNNNTCNTCGCNCNNCNCC

GCCCTATANNGAGNNGTATTACAGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGCGTTCGACAGATAGCCGTAACTTCTGTGCTGTGCCAGCCGCATCCCTGAGACAAG ATGGTGAAGGTCGGAGTGAACGGATTCGGCCGCATCGGGCGCCTGGTCACCAGGGCTGCT TTTAATTCTGGCAAAGTGGACATCGTCGCCATCAATGACCCCTTNATTGACCTTCACTACA TGGTCTACATGTTCCAGTATGAATCCACCCACGGNAAGTTNAACGGCACAGTCAAGGCAT ANAACGGNAAGCTCGTNATNAATGGAAAGGCCANCANCATNTTCCAGGAGCGANANCCT GTCAACATCNANNGNGGTNATGNTTAGAGCTNNAACTNNTGGCGGAATNTTACTNGGGAN TTAAACTACACATGTGANAANGNGTTNGGACTACTTNGAAAAGTGTGCCCNAAANAANG GTGNATNAATCTCAGOSINACTTTTTTGTTCGAAGCCCCCCATGNTTTTTGNAπ ANAANTCACTNANAAAGTTTATACANACHSfTCCCTTNANAATNNGTCNCGNTAATGTTNTN

NTGTGNNAAACTNAAACTGTNTTNTCCCCCCCCTCNNTCAANNNTNCATATCANNTANAA ACTTTNTGCNTNTTGGGANGGGACATNATNNACACATTNGGGCATANCCATTNTACTTGTC ACCCCANNAAACATANGTNGGTTNANNCCTCNTαsWGNGTAANNTCTNNACNTCTTTT^ TTTCCTNNNGNGGNTTNNNTCrøWAAAAAT^^ TCTNC^ANACATNTNGNGTNATAGA<^(^^

TCNTNNNCTTTNNCNGTTNTGNNCGTNTCTσSTCTATNCTCTANCATATTTTATGN^

NNATNNTCTTNAC<-^TCANAANACTGNATNNAAAACCT(^CCCNACGNNCNTCNTTATAA

TACTNNCACTCNATTNGNNTNGNNNATTGTTNATGACANGG

AGCNCTATATGGAGNTGNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCCCCGNTGGACCCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCGAACAGGG CGACAGAGGCATTAAGGGTCACCGTGGCTTTTTTTGGTTTCNAGGGTCCCCCNGGCCTTCC NGGTTTTCTNGGGNANNANGGNC^TTCCGAANCNTTTGNNCTTGTTGNNCCCNGGGNNCC CCTTGNTTTTGTTGNTTTTCCNGGNAAAAANGNNNTAATNGNNTTCCAAGGCCCATTN

NCCCCTNGGCCTTNAAGGNCCAATNGNGAANNTNGNCCTNGTNGNNCTTCCNGGCCTTCT NGAACCCCTNGGNCCCCANAGTCCTTCCAACGGGGGGGTATACANATTNAGANTTTTCTG TGCCCAAACACACTTNAAAAAAAAAGGTTCACNATGNNGGCGCTATATATACGNGCTTTA NATNANGCCATNTGTGGNCCGANACCGANCATCTAANGTGNNAACACCACTCTAAANAN CTTGNCNCNACATATAGAAAANTTCGNGACCNTTAAGGGCANCCAAAAAAACCGCGCCC

NCATGTGGTGAAATCTAAAATATGCCNCTCTTTTTTGTGANAAGAGCNGAAAAATTGTGTT TTTTGCCCACAAANAGGTGGTGNACNTGGNATGACAATTAANAGNGGTTTTTGGNACAAT NGTGNAAAACCCGGAAGAAACNNTTTGTNTAANNCCNNCTNTTCACCCACCAAGTNGNGC CNCNAAAAAAAAATGTTGTTTTTATTCNANNAACACCCCCCGAAANAAAAAGGACNCTNN TTTTNGCTNCCGAAAAAAAATTAATCANCCGGAATTTTTACTNNTTTAATAATTT^

CGCANGGNACAACCAAGGNNNTCTCCAAAAAAAATTTNTTCTACTTNT

AGCNCTATATGGAGNTGNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGCCCCGNTGGACCCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCGAACAGGG CGACAGAGGCATTAAGGGTCACCGTGGCTTTITTTGGTTT(^AGGGTCCCCCNGGCCTTCC NGGTTTTCTNGGGNANNANGGNC^TTCCGAAN(^TTTGNNCTTGTTGNNCCCNGGGNNCC CCTTGNTTTTGTTGNTTTTC(^GGNAAAAANGNNNTAATNGNNTTCCAAGGCCCATT^ NCCCCTNGGCCTTNAAGGNCCAATNGNGAANNTNGNCCTNGTNGNNCTTCCNGGCCTTCT

NGAACCCCTNGGNCCCCANAGTCCTTCCAACGGGGGGGTATACANATTNAGANTTTTCTG TGCCCAAACACACTTNAAAAAAAAAGGTTCACNATGNNGGCGCTATATATACGNGCTTTA NATNANGCCATNTGTGGNCCGANACCGANCATCTAANGTGNNAACACCACTCTAAANAN CTTGNCNCNACATATAGAAAANTTCGNGACCNTTAAGGGCANCCAAAAAAACCGCGCCC NCATGTGGTGAAATCTAAAATATGCCNCTCTTTTTTGTGANAAGAGCNGAAAAATTGTGTT

TTTTGCCCACAAANAGGTGGTGNA(^TGGNATGACAATTAANAGNGGTTTTTGGNACAAT NGTGNAAAACCCGGAAGAAAOSπ ITTTGTNTAANNCCNNCTNTTCACCCACCAAGTNGNGC CNCNAAAAAAAAATGTTGTTTTTATTCNANNAACACCCCCCGAAANAAAAAGGACNCTNN TTTTNGCTNCCGAAAAAAAATTAATCANCCGGAATTT^ CANAAGNTCCAANCCTTT(^WGANNGATGGGGGNATCCAAACAAGGTTTNTTTTTCTTGC

CGCANGGNACAACCAAGGNNNTCTCCAAAAAAAATTTNTTCTACTTNT

TTTANAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCNNTNCCCATQVINNNANNNCTGNNNGGANTNATGGGG

ACGNTTGAAANACANACTCACTACATNCTNCCCNTANACCNGCCNAGGTGGNNCANGTGA CGATGTGATCANAGGGTGGANCCTGNNAATCACGAANANTNCCANAACTNNNGGACCTA TGCCTTAAGGAANGGGTAGNCTTAGCTCTGATANTCCAGGTANTNAATTGTNNCATTGGA AATNNANCATNGANGAGCCTGGCNCTTNCTATGATCATGGNTCCATGGNATTTAANO^ΠT TAAArøCGANAACNNCNCNCTTNCCAAN^

NNNNCAATISINTNNCTTTTGTTGNNC^

TTTTNCANATCCCAAANNNCCCNTTTTTTTTNNTNGNAANTGTT^ ccrrAττcrι NcτττNTNTGTTC^ CTTCCANTC(^TCNNNTNCGTTTANNTCN[NTNNCTCWTATNTTT^

NTTTAATNTNTGTGNTTNNTTTTCTTTCCTTATGTACCTNTANCNTTT^^

TGTATNTWTNNTTTATπCT^^

TCTCNTTNTCAAGTCATNTTCCNCCTTTCTTNTNTCNNNTNTTCNTTNNNTATC ANTATANN(^TNTOS(NTTTTTCTNTCTNTATNTNANCTTNTT^

CANTNATTTNATANTTTTNTTTNTNCTTTCTNCANTTTGNTTA

NNTGCTNNNTNNTCNNGTT<^^

TTNNACAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGGCTTGGGCTGCGTGGGGATTTTGTAATGCCGACCGGAGACTTTGATTCGAAGC CCAGTTGGGCGGACCAGGTGGAAGAGGAAGGAGAGGACGACAAATGTGTCACCAGCGAG CTCCTCAAGGGGATCCCCCTGGCCACTGGGGATACCAGTCCAGAGCCTGAGCTACTGCCG GGAGCTCCACTACCGCCTCCCAAGGAGGTCATCAATGGAAACATCAAGACAGTGACGGAG TATAAGATAGATGAGGATGGCAAGAAGTTCAAGATTGTCCGCACCTTCAGAATTGAGACC

CGGAAGGCCTCAAAGGCTGTGGCAAGGAGGAAGAACTGGAAGAAGTTTGGGAACTCAGA ATTTGACCCACCGGGGCCCAACGTAGCTACCACCACAGTCAGCGATGATGTATCCATGAC ATTCATCACCAGCAAAGAGGATCTGAACTGCCAGGAAGAGGAGGATCCAATGAACAAGC TCAAGGGCCAGAAGATAGTGTCCTTGCCGAATCTTGCAAGGGCGACCACTGGACCACCCG CTTGCCCCTACAAGGACACGCTGGGGCCCATGCANAAGGAGCTGGGCCGAACAGCTTGGG

CCTGTCCCTGGCGAAAAAGGAAAANCTCCCCGGANAGCTGGAACCTGGGCNNGNCCCTTA AAACAAGAATTGGGAAGTACGTTGCCTTCGANCCTTGGCCAAAGGGGCCAGCCCCCGNGG GGGAGTCCNTGCACCCAANCCGANAACTGATGACAATGCCCCCTTTCCNGTTANCCAACC TTTTTTGAGGACCCTTCNGGNAACCCACCTGGAGGAACTTTTTCCGGNCCTTTNGGTTCC^ TTTTCCCGATTTTANCCTGGGAAAAGGNAAAAAACCCCCGGCCN

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGGCCTAAGTTCGACCCCAACGAGATAAAAGTCGTGTACCTGAGGTGCACCGG TGGGGAAGTCGGTGCCACGTCTGCCCTGGCCCCCAAGATCGGCCCTCTGGGTCTGTCTCCA

AAAAAGGTCGGTGATGACATCGCCAAGGCAACTGGTGATTGGAAGGGTCTGAGGATTACA GTGAAACTGACCATTCAGAACAGACAAGCCCAGATTGAGGTGGTACCTTCTGCTTCTGCC CTGATCATCAAAGCCCTCAAGGAACCACCAAGGGACAGAAAGAAGCAGAAAAACATTAA GCACAGTGGAAACATTACTTTTGATGAGATCGTCAACATTGCCCGGCAGATGCGGCATCG GTCTCTAGCTAGAGAACTTTCTGGAACCATTAAAGAGATCCTGGGGACCGCCCAGTCTGT

GGGCTGCAATGTTGATGGCCGCCACCCTCATGACATCATTGATGATATCAACAGTGGCGC AGTGGAGTGCCCCGCTAGTTAAGAACTGCAAAGGAAAATAAAGGACCATTTGACAACCA AAAAAAAAAAAAAAAAAAAACTTGGGGGGGGGCCCGGGNCCCAATTTNCCCTTATGGGG GGGGGNNNNNTNAAAAANNNNNNNNNNNNNNNNTSINN^ NNNNNNNNNNNNNNNNNNNNNNNNTSπs^

NNNNNNN]SπsπsπsWNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNTSfNNNNNNNNN^ NNNNNNN NNNNNNNNNNNNNNNNNN^ NNNNNNNNr>π^NNNNN

TNNNACAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAAAAATTGTAAACAATGCATTCATCGACCTTCCAGCCCCATCAAACATTTCATC ATGATGAAATTTCGGTTCCCTCCTGGGAATCTGCCTAATCCTACAAATCCTCACAGGCCTA TTCCTAGCAATACACTACACATCCGACACAACAACAGCATTCTCCTCTGTTACCCATATCT

GCCGAGACGTGAACTACGGCTGAATCATCCGATACATACACGCAAACGGAGCTTCAATGT TTTTTATCTGCTTATATATGCACGTAGGACGAGGCTTATATTACGGGTCTTACACTTTTCTA GAAACATGAAATATTGGAGTAATCCTTCTGCTCACAGTAATAGCCACAGCATTTATAGGA TACGTCCTACCATGAGGACAAATATCATTCTGAGGAGCAACAGTCATCACCAACCTCTTAT CAGCAATCCCATACATCGGCACAAATTTAGTCGAATGAATCTGAGGCGGATTCTCAGTAG

ACAAAGCAACCCTTACCCGATTCTTCGCTTTCCATTTTATCCTTCCATTTATCATCATAGCA

ATTGCCATAAGTCCACCTACTATTCCTNCACGAAACAGGCTTCAACAACCCAACAGGAAT

TTCCTCAGACGTAGACAAAATCCCATTCCACCCCTACTATACCATTAAGGGACATCTTANG

GGNCCCTCTTACTAATTCTAGCTCTAATACTACTAATACTATTCGGACCCGGACTTCTTNG

GAGAACCCANATAACTTCCNCCCCAGCCNATTCAANTTAAAACACCCCCTTAAAATTAAA

ACCCGGGGGGAACCTTNTTANTTGCATTCCNCAAATNTTACGAAACAATNCCCCAAAAAA

NNNACTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGAATTCGGCACGAGGAAAAGATCCAAATAAAGAAAAACAAGCATTTGTGAAAACAGTT AAAGATCAAGCTTCTGAAATTCAGGTGACAATGATGCTCACCGAAAGTTGTAAGCTCCGA GGTCTTCATCACAGAAATCTTCTTCCTATTACCAATGTGTGTATAGAAGAAGGAGAAAAG CCCATGGTGATATTGCCTTACATGAATTGGGGGAATCTTAAATTGTTTTTACGGCAGTGCA AATTAGTAGAGGCCAATAATCCGCAGGCAATTTCTCAACAAGACCTGGTCCACATGGCTA

TTCAGATTGCCTGTGGAATGAGCTATCTGGCCAGAAGGGAAGTCATCCACAAAGACCTGG CTGCTAGGAACTGTGTCATTGATGACACACTTCAAGTTAAGATCACAGACAATGCCCTCTC TAGAGACTTGTTCCCCATGGACTATCATTGTTTGGGAGACAATGAAAACAGGCCGGTTAG GTGGATGGCTCTTGAAAGTCTGGTTAATAATGAGTTCTCCAGCGCTAGTGATGTGTGGGCC TTTGGAGTGACGCTGTGGGAACTCATGACTCTGGGCCAGACACCCTACGTGGACATCGAC

CCGTTTGAGATGGCCGCATACTTGAAAAGATGGTTACCGGATAGCCCAACCAATCAACTG TCCTGATGAACTATTTGCCCGTGATGGCTTGTTGCTGGGCCTTAAAATCCCGGAGGAGAAG GCCCAAGTTTCAGCAGCTTGGGTCCCAGTGGCTNACANNAATTCCCTGGCAGCCCCTGGG GGGCCCATTGTCTNGACTTTTGCTGTCACAAGTCCTCCNAAGCGTNCAGGAAGGAAAGGT GCCCTGCCCGGCCCTNCTTGGGANCCCAATTTTNGGATGCCCCAATACCTCACNGCAANG

NCCCCAGAANNNATTTTGTTTTCCAAAAACCNGGGNCCTTAGGNA

NAAAACTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCTGCACGTCTAGGCTCGCCCGCGCCGGCTCCGACCAAATCCGATGGGACTCCGTGA

TGCTTCTGTCCTTGGCCTTTAACGAAAACTGTCCAAAAAAGGGAAGAAGTGTTGGTGGGT

GGGGGGAGGAGGGGGGNCCCCCTTTTCCGTGGGCACGGGGAGGAAGGCCGGCCCGTTAT

GGNCCNNCCAACCCCGGGTCTGTCCCANCCCTTAACTTGAGCNTGGCCCNCGTCCCTTCTA

AAGGCNCCNGGGCCAAACNCNTNTTGGGACTGAGGGCTTNCTTTAAGGAAAACCCTTGCT GGTTTANGCCCTGNANGGNATTTGATCATTATATTTTANCATTTAATTCTCTCCTATTTATT

GACTTTTGNCAATTACTNANGNTTGNGAAAAAAAAAAAAAAAAAAAAAANNNNGGGGGG

GGGCCCNGNNCCNATTTNNCCTTANNNGNNNNNNNATNANANNNNNNNW

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNTSπSiNNTSlNNNNNNNN^

NNNNτ>lNNNNNNNNNNNTSINNNNNN^

NNNNNNNNNNNNNNNNNNNNTSINNNNN^

NNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NCTCACTNAGOS[CTNANGTCTAGTACNCNAN(^GCCCANCATTANTTTNAAGCCCNATAN

TGNAGTTCGNCATTACNNGGNCATNCTCCGCCTCCTATNACATAGNNTCTNANNACCCAN TACCTNTATNATANTANTTACCNTACATCCNAANTTTATTTNNTCNATGCTTACTAAACCN

NANAACNTTNANANCNNNNCTTNTTCATATNAT^^ CTAOSINANCTATTTACNCTNATNATTC^ CNTTNAATAANNNTNNTATNANTATNC^

NTITNAA(^ANNNTCTNTCAANCACCCTTTATNATNCTCTTATTANNNNCANTNN^ CCNNNANTNTTTNTTTTNNNANATCANTNANNCGANAATTTACNCT^

AAANNCTCCCTANCANCCTCNTCTTCTCTTANNAATNTNTCNCNACNGCCCNCCANTTCGA ACAATNCTCNNANTNTCATCNACCNCCCNTTAACNTATNCTCNCANNTNTNTαSINTNCCN NNACANTCNCNACATTTTATNTATATOSlNNTTNTNNNTSfAA(^GAα^ TCATGCAANNNANATNTTTNNANGTTTACCTTAANTTATCANCTNTTCCTATAATCTNNTA NCTNNNTNCTNTATNNNANCNNATCTAAACAATANNCTGCCTTTTCCTCNATCTANCA

TTATATANANTNNTCCTATNTNNNNNCAATTNCCTAANCCCNNNCTGANTCAACCTAACA NTCCAAACNCCATNNNNNNNTTANCTNTACNTTTGCCTNCNATAANCTTCANACTTCNCTC

NCNINCANNTCTCTTNNNTNCNCTACAAACTTΓANCANANNTCNTCTTTN^ AATNNCAATTANNATNANNNAAGOSFNNNTAACANTTNNTGTGNCTTCTCNNTCTACΠ^

CCNCCACNATCCCTCACCCNTCGTNNCACCTCTNATNANTATATNANTTNTTCNAACCANA GCACNGCGNCTCANCTTCTNTNCANTATNATTATCTCATCTNTTCTNCTCCTCCNCTCNTCN ATCAACGCTTTNCNTANNNTAANCAAANCTATCNNTCATACNCTTTTNATTATCACCTNNC

TTATATT ΪNTαWANNCNANATATANCACCACTNTGCTCAACNANTCNTCTTCTNA NNTN (^ACANCNCANATANNCCNCTGNTTACNCTTCCNNNTAANNNNCGCATNTATATACATCT

NCNCTCNNANACANTNCNCTNCACNANNNATAATNNATACNTCTNTACTCTATATNNTCC ACNOSπSiTGTNNTCACCTACACANACANANTCTTCTNNTNATATATCNCGNTACACTTATAN ATNANTNCNNGCG

TTNAGCCCTTATANTGAGTNGNANTTACAAGGGCGGCCGCTCTAGAACTAGTGGATCCCC

CGGGCTGCAGGCTGCACGTCTAGGCTCGCCCGCGCCGGCTCCGACCAAATCCGATGGGAC

TCCGTGATGCTTCTGTCCTTGGCCTTTAACGNAAAACNGTCCAAAAANGGNAAAAGNGTT

GNNGGNGGGGAAGNAGGGGGNCCCCCTTTTCNGTGGNCNCGGGNNGNAGGCCCGTTCTT TATTNTCCTNCCNATNCC^CTTNTNNCCCATNCCNNTAATTTNTCTNGTCNGTCGTCNATTC

CNTAANNCCTCTNTNNTCAAAAANCTTTNTNNGGANTANTGCTTTCTCTTTlSπS GGAN^

NCTTCTTITTTTTACCNCTTGNNCNGGGTTTTNCTCCNTTπ

NTNCTATTNTTNTCANATTIINTACAGTC

NNTTCTTTCTNNNNGGNNCNNNTCTCCNCCTCNTNTNNTTTπ TNAATCCCTTNTNTNCTATNTCTCTN^

CNCNNTCTCNTTCNNT(^TNNCNTANNNCTTTN(_^ATCTCTTNTNCCCCTTCNT^

NNNTNTTTTNTTCATTATNNCTTT^

CTNTNTCCNTANNTNATTNCNOSπSINTTCTTTNTTAGTNNNTCNNN^

NTTNNNCTC CNTTTNr>^ NCNCTTNTTATNNTTNNNTTATNTT^

ISINNAAATTATCNTTTACAGNNNTNTTT^^

NTNCNNTTNTNCCNCANTNTCNNNTACNTNTTCTNTCCTNNTCTNTNNTANCG

TTNAGCCCTTATANTGAGTNGNANTTACAAGGGCGGCCGCTCTAGAACTAGTGGATCCCC

CGGGCTGCAGGCTGCACGTCTAGGCTCGCCCGCGCCGGCTCCGACCAAATCCGATGGGAC TCCGTGATGCTTCTGTCCTTGGCCTTTAACGNAAAACNGTCCAAAAANGGNAAAAGNGTT GNNGGNGGGGAAGNAGGGGGNCCCCCTTTTCNGTGGNCNCGGGNNGNAGGCCCGTTCTT TATTNTCCTNCCNATNCCNCTTNTNNCCCATNCCNNTAATTTNTCTNGTCNGTCGTCNATTC CNTAA WCCTCTNTNNTCAAAAANCTTTNTNNGGANTANTGCTTTCTCTTTNNGGANNAA

NCTTCTTTTTTTTACCNCTTGNN(^GGGTTTTNCTCCNTTπ NTNCTATTNTTNTCANATTNNTACAGTT(^CTNTNTTTTCTCNTANNNATAA NNTTCTTTCTNNNNGGNNCNNNTC^ TNAATCCCTTNTNTNCTATNTCTCTN^ CNCNNTCTCNTTCNNTCNTNNC^^

NNNTNTTTTNT CATTAT^WCTTT^

CTNTNTCCNTANNTNATTNCNCNNNTTCTTTNTTAGTNNNTCNNNNTCTCT^ NTTNNNCTCTTCNTTT]SINrWCT^ N^CTTNTTATNNTTNr^^ NNNAAATTATCNTTTACAGNNNTNTTTANTCTACTTTCTCNNTCTCNATTOW

NTNCNNTTNTNCCNCANTNTCNNNTACNTNTTCTNTCCTNNTCTNTNNTANCG

NNAAAAGCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGTTGGTTAGAGATGCTCTTGAAAGACAAGAGAGATAAGAG

GTGTAGAGCCAAGTCTTCTAGGTGGCTTGCCCAGGTCACTCTACCTCTGGCCTCTGATTCT CAACATACATACCTACATGGCTGCTCTTGTTAGTACAGNGTTGATTCTCTGGAAATTANCC GCATGCCTGCAGCTTGCTTCGTCTGAGGATAATGTCACCACCAGAATGGCTGCTCTGACCA TTTGCCTGGGGGCTTTCTCATGGCTTTTTGAACAAGGANGCTGGGCANCCTAAAAATANTT CCAC(^TTA(_^GCATNGGTTATGCCTTGGNGGGAAGGGGCCTGGNATACTTTTCACNTTAC AATTCTTAAGAGAAAGANTAGGGCCTTACCTAATCCAAGNCATTAAAATTAAAAAATGGN CTTNAGNN(^TGGANGTTTGGACCAAAATTTNTTTTGAATTTAACCCCTGGCCCAAGT TGGTTGGA(^CCTNAGCCAGTTNTTAATNCNGGNCCAAAAACCTGAANGGANCGAATNAT TANCTG(.KNGGTACCCATTGA<^TTCTAACTTCCTNTTGGCCCCTTATNGCAAATNCCNTT

AGGAATGAAAAACCTTTTGGGATTGGNGAACCCAACCTGAAANGGGANTTCCAAGNCCTT TGGTTGAAACCAAANACAANTTCCTNTTGGCCCCANGGGAAACCTTAAAATTAAAATNTN NCCTGGAAACCCGGCCTNGGGGCCATNCCCAAAAAAACTGGGCCCTTTAGGCCATTTNTT TTAATTCCCATAAAATCNGGNCCTTTGGGGNGGAAACCTGGACCCAAATGGGTTGGGGTN GGGTTTTTTTTNCCTTGGNNTTNGGGAANGGGGTTTTNCCCAAAAGGT^^ αSITTTTTGGGAANGGGGAAATTGT

TTNAACACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGATATCNCACTGGTAAAAGAGATGCAGTTGAAGAAACCT

GCTGAGTTGAAGATTTCCTAAATTTACTTTAAAGGGAATAATCTGGGTTTCTTAACTGCAG GGGTTTTGAAGATATGACATCCTAGAGTAATATCAGAGGATACTTGGAATTACCAGGGGC TAATTTAGAAAAGAAATTGTTCTTTTAAAAGGAAAGAAATTTCAGTAAGAATAATCAGAT TGGCCCAAGGAGCAGGTGTTCAGAGTGTTACTGAGTAATATTTACTACTAAAATACTTAA AGTAAAATAAGTAATTTTAGGAAATGTCTTGATTGAACAAAGTTATTTCTTAGAACAGTTT

ATGTTCTATCAACGATGTTTAAGTATTTCTATCAATTATGGAAATCTCTAGTTGAAAGAAT TCTGGAATTCATGATAAGGAATCAAGATTTGAAACTTTGAAAATTATACTGAATAGTTGCT AATCTATAAAGATGCTTTTTAACATTGTACATTTAGGAAACATGGGATTGGCCTTATTTTA TACATACTCTTΓΓAAAATATTGNCATTGCTTAAGACTTTTCTTGAGAGTGAATTACCTGGG AATAACATAAATTCCATGCAATTTTAAGTATTTGCTATTNAAAACCAGGTACCTTTAATTG

NGGGATATGAATCTGACTAAATGNGCTNTTACCAGGNAATACTATGNCATTCTACCTTATC NTTTTGGAAAGGTATTGCTTGAATGTCCTTAAAGGTTTCTACCNCATAGNGATTCTGGAAG TTTTTCCAGTTTGNNTTTCCCNCTGGAAA ACNTTTCAATTAACTTTAGGAAGA

TTGAANACAAGCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGNSfCNAGNTNTTATGNTTTTTNNTACCGNNAACCTCANNNNNTNN^

CNGATTNAAANCTATNNTGNGTCGNANNANATANNNGNTTTNTNTNNNANAANGNGGGN CNNAANTNGNGGGNCaSfNAGGGNAAAAACCNNCCCNTTNNNCTTCNNNANNGNNGGAAA

GGNCNTTAOSrCNCCCNTTTTTTTTTTAAAAANGGNNCNCα^

ANNTSπSfTTNCCCGGGAAAACCGGGNANNNNTTNAAGGGCNTNCCNNAAAAANCCNNTNCC

TTTNNNAAAATTCCNNTTTAAATNAAAGNNCOSfNANTTNNCGGGGNANNT^

NTTTTNNCNNCCGNTTTNNTANCCN ^ AATTTTTNNNTTTTTTTTGGGAANTAN^

AAAAANANTTTTCCCCCTNAAATNTTTTAAA ^

TTNNGGGAAATTTTTCCNNACCGTTTTO^

CCCCTNGNNTGGAATTTCTGGGAAGNGGGGNAAATTTTCACTTTTTCCCCAAANGANAAA

AANGGN AAAATTITTTTCCCCCCCNCAGAAACN GGGGGGNAAATTCGGGGGC^CTTTTTTAANGGNCCCCCCCTC(-^GTTTCCCAAAAAAANC

CCCNNTGGGGGGGGCCCCANNNGGTTTTTTTCNCCTTGGGGGGGGAANTTNTNTT^^

AAAAGGGTNTTTTTTTTTTNCCGGGCCGNGGN^

NACCAAAAGGGGGGNGTTTTGGTTNCCNNT

TNNNNAAAACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAGCTGGANGGNTGCATGCATTGCCGCGTGTGCGCCAAGCAGCTGAGCGAGTTGT GTACCGAGCGCGACCCCTGCGATCCGCACAAGGGCCTCTTCTGCGACTTCTGGCTCCCCGG NTCAACCGCAAGATNGGTAGTGTGCACCAGCTAAAGATGGTGCCCCCTGCGTTTTCGGAG GAACTGTGTACCAGAGCGGAGAGTCTTTCCAGAGCAGCTGCAAATACCAGTGCACGTGTC

TGGACGGGTCGGTGGGCTGCGTGCCCCTATGCAGCGTGGACGTCCGCCTGCCCAGCCCCG ACTGCCCCTTCCCTCGGAGGGTCAAACTGCCCGGGAAATGCTGCGAGGAATGGGTGTGTG ATGAGCCCAAGGANCACACCGTGGTCGGCCCTGCGCTCGCAGCTTACCGGCCGGAAGACA CGTTTGNCCCAGACCCAACCATGATCCGAGCCAACTGCCTGGTCCANACCACAGAGTGGA GTGCCTGTTCCAAGACCTGNNGAATGGGCATTTCCACCCGGGTTACCAATGACAACGCAT

TCTGCAGGCTGGAGAAACAANAGCCGCCTCTGCATGGTCAGGCCTTGCGAACTGACCTGG

AGGAGAACATTAAGAAAGGCAAAAAGTGCATTCCGGACCCCCAAAATCTNCAAGCCTATC

AAGTTTGAGCTTTTNTGGTTGCNCCAACCNTG^

ATGNGCCCAANACGGGCCGGNGGTTGCACCCCCCCAAANAACCCCCACCCTTTCCCGNNG

GAGNTTAAAGGGNNCCCGGANGGGGGAANGGNTNTTNAATNAAAAACCTGNAATTTTTA

ATNAAAAAAACTTGNGCCCCTNNN

GCCTATNTGGAGCTNCATCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGCTTGCTACCTTCTGCCACCGTTCCATGGTCTCTGGAAATCCTTCCCACCAATGAAAG CCTTCGGTCCTGGCATTGGCCTTCCACCTAGACCGGCTTTGCCCTCTCTCTGCCATCCTCGG TCCTCCAGAGACCACACTGCCTGTCACAAAGAAAACCACCACCTCGGGCCTGCCAGCCAT CAACTTGGAAAATCGGGCCAGCTGTCTGCTGCTCACGTCTCCCAGGTCCAGACCAAACGG GATCAACAACCCACAGTGGTGACTCAGTCTCTTACCCCAGGAGCCAAAGCAACACAAAAC

AATTGGTCAAACATCGTTGGGTCCGATTCTGAGAGTAGGTGATTTCTAGACATGTCTTTCA GGTGACCCTCAACTACCTCAGGTTTGAAGGCCCTAAATTAAGCTGATACTACTCATGGGG ACAGACCGAGGAGGGTTCGGAGAAATCTTGGTGATAACGCACTTGTCTCAAACTTACAAC AAACTCACGTTTCGGTTTGCAGGGGGTGGGGTTGGGGTTTGTTTTTCTTCTGTTTT^ TTTCCCCCCAAATTTTCCATTAAGAATAGTTCCTACAAATGAAATTTCATTTCTCACTGAGT

GCCTACCTTCCCAGGGGCAGGTANNCCCTGGGNTTTGTTTCCTTCCAAGCAGTACTTTTAT TATTNGGNTATTAANAACTTTTCTTTGTATAATACCATTGGNATCTGTGCTTTTCAATπ TCAANTAAANACCTTCNAACCCTGGCAAAANAAAAAAANAAAAATNCNGGNGGGGGGGC CCCGGTACCCANNANGNGNCTNNNANNGTGA(- TTT^

NNTTANTCTCNGNGNNNCTCNTGCNNTNTNNCTTCGNCCC

ACNCNNTNTCANNNTANTAATTTTCTNTTTNNTTTTNTTT^ NNNNTTCTTTNCANTCCANGATNTCGTNT^^

OSfTAATATNTTTNAGNANAACTGGAGCTCCANCGCGGNGGGCGGCCGCTCTAGAAACTAG

TGGATCCCCCGGNCTGCAGGCTGCNNTGTTTTATNNTNTNNTTNNACCGTATANCATCNNN

TCCAANTTGNTSlNTTNNNGTCπ

ANTTNATNTTNTTCTTTTNNCATT^ TTTNTTTTNATNANATTNTCTCTT^^

TGATTNCTANNTTANAAANNTTCGTTT^

NCTTCNNTTCNTTTACTTCANNTNTTTATNGTNTAANATTANGACTTATATATNTACTANTT

TNTTNANTNGTATTTCGTNNCTTNNTC^

CAGTNTTTTCNNTTTNNATNTTATN^ NTTNGNANTNTATTATTTTNATNNNTTNTTNOSITaSfTANTN^

NTNTCCTTTNAANNTNTTTCNNTCTTTCTAATTCTNTCNNNNAGANTCAANCNATNTT^

NTCTTNTNTTTNNTANTNCNTC(^TNTTTCTCTNGAAAAATCCATNATCGTTNNA^

AAANTATNTNTCGTTTNTTCATTNCNCTATNCNTTCNTACTACANNNATCTCATTGTTCATT

ANTTTCCATTNCGATANCGNGNGNNNTGNTTTCNTNTNTATCANNTNN(^ACTNTNTN AATNTCNANNNNACCGANTNGGGNTCCNT^^

TCCCCGTTTTAACNCCCCCCCCNCCCACANAATNTNNGAAAAANCTCTCCCTTCCTCCCCC

TNAANGAGGTNNNGCGCGNNNNCCCCCCTTCCCAAAAAAAAAAAANTGTAATTTTGGGG GGGGGGGGGGGGNANGNGTTTTGGGTTTNCTNTTCTπ^ TNGNGANGCCCCCCCCCCCCCCCCCTNCCCCCCCNCCCC(^CCANCCCCCNCTTTNNANCT

TTITTNGGTTNGTGTGCCAACNAAGNNNTTTTTTTTAGNNGGGGG TATNGNGNGNGGGGGGCG

TNCTTNTNGNNGGACNCGANCNANO^

GTATTACAGGGGAGGNCGCTCTAGAACTAGCGGACCCCCCGGGCTGCCANGNTTGCNNGC C(^AGGCCTGG(3NNT(_^TGGasrCCTGGTGTGATACGAACGCaSlNTSfNNN^ ANNCTGNCTCC(^TGCNOSITNACCACCTGANTNTCCCTNNCNACCNGCCACNCNGNGNTN TTTTNNTNGNGTTNTCCTGTCGNTTGNTCNCGAGAAATAANCNNTNTNTTTTGNTCGAC^

NGANGNCCNNCT<^TTTTCTTTGNTOT

CC3SrCΗCNCCαS[NTNN<^TCGNAN^

NNC ITT^CCGNGNNCNCGNCANl^JNNOT NCCTGNTTNTTCGAANATNCTCGTNGNNr>^^

CCCCTCMNGCNNNGACGANCGNNNCCTNNNATTNTO^ GTANGT(_^GTNGαSfGNTNGNNCTCO rTNTσsπSINNATNCGGNNTαW

CNCNNCATCTNNANNTNNCCTTTNTTN^ NTCCNNΉNCNNGCTCΠSI(^TTTΓCNTCCGNCNTCTNTTNTCCNNNN CM^GTTNTNGNNC MNCGCNNCTNNCCTNCTNNNNTTTNNNT^

ΑSTGTTACTNGCTCTGCΑSΠSF(^CCTTTNTNCTCTTCTTCTCCNNCNGCCCNCCCGCNCCGNC TGCTNCC^CNTCTTTAATTNTTCATCCANCNNNCCGCNCTCGNTCTATCTTNNCNNTCNAN CATNTTNGCTTNNCTGTCNGTCCGNCCTNTCGANCTGTNNTATCCNAGCTATTNNATCNTA CTATC<^CTNGTCNGGTCCTTTTTNTTCCTC^ (^TTNNATNNTGCGCGCNNNTGTTNNCNTCCTTNNOSRCGCCTCTCT^

NCTTCAN(^ANNTNNCTTCA(^CTCTTATANANNTTCNNTCNNANNCNTNΑ«JTACANTNG NNTCCGGTNNATNNNGAGAGCGTCTCCGTATAGNCGCGCNTNANNTNTCNCATCGNTCG

TNNANCNANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGCCCGCGGATCTGTCTCTTGCTTCAACAGTGCTTGGACGGAACAGACCCAGG GACGCCCCTTGTTCAAGCTCNAN(^ACCTTCAANCTTTTTTTCNANCCNAANCNTTGGANN CNANCNNTNNACTNGNCGNGAACANCCGGGANCNACCNNC^TTTTTTAACTTCNTANTAN TANOS1NNCAATNATNAACNNCCAAAATNNNCANAATTANTCTACCNANGGGGANGNCNG CNGCNACCGGCTGGGTAACATGNNACTGGGGGCCTTCTACACCTANCTTTCTCTGGGCTTC

TATTTCGACCGCGACGANGTGGGCCTGNGAGGGTGTGGGGCACTTTTTTTCGCGAATTGGC CANGGAGAAACGCCGAGGGGCGCCGGAGCGTNTCTTTGAAACTGCGAAANCANCGTGGG GGGCCGCGCCCTCTTTCTGNGCGTGCNCAAACCNTNTCNAAAANAGAGGGGNGAAACCAC GACGCTNTGGAGGGCGCNCTTNTCGTAANAGAANAAAACTNNATAAACCCTGTTGGATNT GCATGGGCTGGNTTNTGCCCCGGAGAACCCCACATATGTGACTTTCTNGAGNAACACCTT

CTATATGANGGAGGGGANACTCTTCATNAAAAANGGGNGGACATCTTGNNCAACCCTCNG

NCCCCTCANCCCCAACTAAGGAAGCNTTTTGGGGGAACCAOWGGGCCNTTTTAGNAAAC CCCCCTTAAAAATAAGGGGGGNGGCTTGGAAAACCCCCTCTTTTGTAGGNTACTTAAGGG AGGNTTTTTTTTTAAAAAACCTNGGGGGCCCNCTTTTTTAAACCCTπ

GGAAAAAANTAANAAGNTT

TNNANCNANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCCCGCGGATCTGTCTCTTGCTTCAACAGTGCTTGGACGGAACAGACCCAGG GACGCCCCTTGTTCAAGCT(^AN<^ACCTTCAANCT^^ CNAN(_MNTNNACTNGNCGNGAACANCCGGGAN<^ACCNNOSfTTITTTAA

TANCNNNCAATNATNAACNNCCAAAATNNNCANAATTANTCTACCNANGGGGANGNCNG (^G(-^ACCGGCTGGGTAACATGNNACTGGGGGCCTTCTACACCTANCTTTCTCTGGGCTTC TATTTCGACCGCGACGANGTGGGCCTGNGAGGGTGTGGGGCACTTTTTTTCGCGAATTGGC CANGGAGAAACGCCGAGGGGCGCCGGAGCGTNTCTTTGAAACTGCGAAANCANCGTGGG GGGCCGCGCCCTCTTTCTGNGCGTGCNCAAACCNTNTCNAAAANAGAGGGGNGAAACCAC

GACGCTNTGGAGGGCGCNCTTNTCGTAANAGAANAAAACTNNATAAACCCTGTTGGATNT GCATGGGCTGGNTTNTGCCCCGGAGAACCCCACATATGTGACTTTCTNGAGNAACACCTT CTATATGANGGAGGGGANACTCTTCATNAAAAANGGGNGGACATCTTGNNCAACCCTCNG CANGGTTGGGTGGTGCCCCAAGNTGGGGGTGGGGGGAAGAATTTTTTTNNNAAANGGGTC NCCCCTCANCCCCAACTAAGGAAGCNTTTTGGGGGAACCACNNGGGCCNTTTTAGNAAAC

CCCCCTTAAAAATAAGGGGGGNGGCTTGGAAAACCCCCTCTTTTGTAGGNTACTTAAGGG AGGNTTTTTTTTTAAAAAACCTNGGGGGCC(^CTTTTTTAAACCCT^ GGAAAAAANTAANAAGNTT

TNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCACTAATAAAAATTGTAAACAATGCATTCATCGACCTT CCAGCCCCATCAAACATTTCATCATGATGAAATTTCGGTTCCCTCCTGGGAATCTGCCTAA TCCTACAAATCCTCACAGGCCTATTCNTAGCAATACACTACACATCCGACACAACAACAG CNTTCTCCTCTGTTACCCATATCTGCCGAGACGTGACCTACGGCTGAAATATTCCGATACA

TACACGCCAACNGAGCTTNNATGGTTTTTATCTGGNTATATATGCCCGGAGGAACAAGNT TATATTACCGGGTCNTACCCTTTTCTAAAAACATNGAATATTNGAGTNATTαSfTTTGNTTA CANNNATAAGCCCNNNANTTAAANGGANTCCNCCTACCNTNAAGGNCAATANTANTNTN NNGNACCACAGNCNTTAACCANCTTTTAATAANCATTCCATNNCNTNGNACCAAATTAAG CGNAAGGAATTNGNGGNGGATTTTAANAAAACAAAGCACCCCTTACCCAATNNTTGGNTT

TCCATTTAATCCTTCNNTTAATNATCATACCAATGGCCTTAGNCCACTTATTTTTCTTCNCG NAAAANGGTTCCAACAAACCCAACAGGAANTTTCTTANAACGTNNANCAAAATCCCNTTC CNCCCCTTCTTTTTCCNTTAAGGGCCNTTTTAGGGGNCCCTTTTACNAATTTAAGCCTTAA^ ACCCC(^AGGCCCTTTTCCNCCCCCGACCCTCCTTGGGGAACCCCANAAACTTACCCCCCA AGCCAATTCCATTTAAAAAACCCCCCNTTTAAATTAAA^

TTGGGAAACCCAANTTTTAAAAACAATNCCCCCCCAAACCTTGGGGGGGG

TTGANANNGCTGGACTCCNCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCNCCCGGGC TGCAGGANTTNGGCTCNAGGATTTTNNNCTGNTNCCANNCATGCAACTTGAANATGGGNN

NCTNNGTTGAACGATCCACTATGGAAANGGAAAGNGNNGNCANCTGGTGTNTCTTACATG

GANGGNGCTCTAGNANATTCCCACCTGCCTACTGNAGAATNCCNATGNTACAACNTAGAT

CATACATGNCGNTANCTANNANANCANCTNGCNAGTTGANNATGAATNNANTCNNNNTG

GNCANNNACNNAATANGATNTNNTTGNNNNTGTATNTAATNNTAAGATTNNACTTAN^ NCNANNTTNCNNNNAGTANNCTNCNTACTTNTNNGGNANC^GCNNTNNTNANTACCNAN

NTTNTTNGNGTNACTCNAANTNNTGNTNCANTTNNTGNNTANCCNCTNNANTCCTCATCC

ANCTNTNTGATANNNCNTTTGCCCCNATACCNTNTTNTCTTTCGNNΗTTTCTTGNCTCNAT

NTNAACNCTTTGATC<. ATr>INANNTAA

TCTNCTTNTACTGTTTNNTNNTNAAT^ TCTT(^GTCTNTTCTNATA(^CTTNGCTNNCTTTNCCTNCTGTCTCCNANTTTCCCTNCTCC

ATNTOSITTTTTGACCC^TGNN(^TCCCCαWANNTTσS[NTCAGNA^

TTNTTTATTCTNCNTTNTNTTTCTTACNCCTNTNTCNCTπ

CATNTTNNTTTTNNNCT⁽^ANAAT

(^TCTNANTNTNNCTTNNTTCTGNNTCACTNTNNTNNCNNCTCT^ CTCGAt^TTCCTACAGTCCTCNCTNINTNNTTTNTTCNTNCTATCTTATATTNCTNTCANNT^

NCTGNNNCNNCTNTGTNNTNCGCTCTTCNTCTANNNCTAGATAGTGANCTCATCNTCTAAT

TTTCTNCTTTCCCTCACCT NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTAGCTCCTCTTCATCTCCCCAGACCGGCCAGCAGGAACCCCCAAAGCCTNCCTGAG TCTGACAGCCAGGACGTGGGGCTGAGGGCCGGGAACAGCTTCCCCCAGGCAGCTCCTGCC AGGCTGTCCCGTGGATGCTTCACTTGCCTTTTTCCTCCTCTCCCAGAACAGTATTTGGGAG ATTTTACTACTTATTCAGACTCCTGGTTATTTATTGCAGATTGGCAAGTGCTTGTTTGGGGG

ATGAAGGGTAGGGCTCAGAAAGTGGAAATATGGTCTTCCTGACCTTTCAGGTCCTTCAGC ATCCTCTTCTCCCTGCCTCTGGGACCTTCCTGGTTTTCCAGGAGATCCTGGCTGGAAGGGC TCTGAGCTCTGTAATAGAGCTGGGTCTAAGGGGAACTGGTGTGTAAAGACCCTGGCATGG GGCAGAAACACACTGCTTGCCAGCAGCCTGGTCATCCTCTTCCCAGAACTTGTTGGCTGGT AGTTCACTCCCAGCTGGATCCCTTCAGAGCCTGAGTCTTGGGCCACAGTCTGGGACCCAGC

AGACACTGCCCAGGACCCTGATGCATTCTNTTNTCGCCTGTCCCTNTGCCCTTCCTTCCTGG ACCATACTACTTGGAATCACTGNAATCTGAATTCGCCTTAATTGGCANGGCCTGGGTCCAG TGCCCCTNTCCTTGGNCCTTGNAAGAAAGGGCAAAAANAGCNCANGGGACCCCTTNCCCA GGNTAANAACCGAGCTTCCCCCAATNGGGAAGGAACCTGCCGGTNGGCAAATTTCCCCCC TTGNCCCAACCCCAAAAATTTTTAANGGGANGGNCCCCAANAAACCCNNAAAACTNCCCA

NGGNTTTCTTAANTTGGGAACCTNCCCCCC(^GA(^TTTTGGACCTTGTCCNANAAAGGAC N

TNNNACAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGAANTNGNCNCGAGGCATGGCTGCAGTCACCATCTACAGTGATTTTGGAGCCCC CAAAAATAAAGNCAGCCACAATTCCCATTTATTNGCGATCAAGTGATGGGACCAGATGCC ATGATCTTAGTTTTCTGAATGTTGAGCTTTAAGCCAACTTTTTCACTCTCCACTTTCACTΠ CATCAAGAGGCTCTTΓAGTTCTTCTTCACTTTCTGCCATAAGGGTAGTGTCATCTGCATATC TGAGGTTATTGATATTTCTCTCGGCAATCTCGATACCAGCTTGTGCTTTCTCCAGCCCAGCA

TTTCTCATGATGTACTCTGCATATAAGTTAAATAAACAGGGTGACAATAGACAGCCTTGAT GTACTCCTTTTCCAATTTGGACCCAGTCTGTTGTTCCATGTCCAGTTCTAACTGTTGCTTCC TGACCTGCATATAGGTTTCTCAAGAGGCACATCAGGTGGTCTGGTATCCCATCTCTTTCAG AATTΓTCCATAAGTTTATTGTGATCCACACAAGTCAAAAGCCTTTGGCATAATCAATAAAG CAAAAATAGATGTTTTTCTGGAACTCTCTTGCTTTTCCAATGGATCCAACGGATGTAATGG

TTGAANAAACTGAACGGNTCTATGANGACCTAAAAAGACCTTNTAAAACTAACACCCAAA AAAGAAGGCCCTTTTCGTTATANGGGACTGGAATGCCAAAAGTAGGAAAGCAAGAAACC CCTGGAGTAACANGCAAANTTNGGCCTTGGAGTNCCNAAAGGAAGCNGGGCCAAAGGCT TACCAAAANTTTGCCAANAAAAACNCCCTGGGNCATAAACAAACACCCTTTTTCCAAN

GCCTATANNGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGNACCATCTANCNNGANTGNNGNTGANCGGNCNNGTNNTGAGNAAANTNANNNCNG AGAAGACCNTGGTNGTNGNNTTGCTGCTCATTGACGTTGNAGNNCTTGAACGAAGCTNCN TGGCTTGTTGCCCTNACATTAATNNAANGNGNAAAGNNNTATNANCACNCACTGCNGTNC

ATA(^ANNNTSINGCNCANNNGAGCTCTNACCANCAAGNNNNTNNNGGATNTGCAGAANNN TCTNTCNAANTSINGCNNNNGNACTACANANAOWNNMSTGNACTTAGANNNAANTGCNGCA TNCANTGNAACNANNNGGCNTNATGCNANNNNNTGGANNNGGAACCNNACANNCGATGG AATNNGANNTNCNTAGANNCGANAGCCCNNTTGACTANTTGAATAAGGCNNNTGNACCTT TCATAAAGANNGTNGAAAAGCNGATNTACNAGGCCATATCGTGNTGGCTNGAATNGTAC

ANNCTGCTCNTGTTATGATAAACCTATTNCAATACTAAATAACCTAATTCNTGCTGCTCAT ACATNTAANATGCTGCTTTATACTTTGNNCCANGCTGACCCNTTCNTGAATATCCATNCAN NNTTAGGGNCATGCCNTNNAAATCTTNTTNTCCTTGNCCAGAAGGCGNTACCANATNTNN CAATANAATTTAGCATGGACTAGGAGGCCCTGAATNACCCANGGACATTACGNNGGANNT TGTTAATNCCATAATNGAANCNACTNCCΪ«INGTGNAACNATGANCNCTNNCGANCCNTANG

NTGGTTNNTNGC(^TAGOSINAATTT(^CNATNCNAAATTTGGNC<^ GCTCCTAATCTNNTNAACANTTCCOSrCTTC^ NTITAANTONfNCCANNNNTl NCGGGANNfW^^ NTTTNGGGCCC

GCCTACNGGAGCTNCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGG

CAGGGTTTTTTTITΓTTTTT^^

TTTNAAAAANCCCCCCCCAAANCCCCCCANGNANCNTAANNNTTC<^TTTRMCCCCCCN AANGAAGGGCANAANN(^TTNNAAAANTTGGGNGNAANCCCAAAAANTTTTTNAAAGGG

CCCCNNαsπsFOSfNGNNAAANTTTTTNGNAAAGNCCCCCCTTTTA^ TNOSlNGANNGGGN(^GNAANNCCNNANNGGGGGGGTAACCCNNGGNACCGGCCNAGNA

NNTCNGGCCCTTNNCCαWTTAAAAANTNCCAAAANAAAAAAGGCGGNNNANTNGGGTN

GNAAAAATNTGGNAAGGGGNTNTTTTTTTTTNAAAA^

CCTCCCGAATTTTNTNNGGGGGTGNGTTTTTCNGCCCCNANNAANAAAACCCCCCCCNGG

NGGAATTT(_^CCGGAGNAAACANAAAAAAGGGGGNNTTTTTTTNAAAACσSfGG^

GGCNCCCCTCCAAAAAAAAAANGGGGGGGGGGNGGGGGGNGAAANNTTGGGNCCCTTTT

NCCGNGGCNNNAANTTTTTNNTTTTN^

ATTTTTTTCCCTTAAAAAAANNNCC^GGGGGGGCAO^

TTTTCCCCCGCCCCCCNAAANNACGGGGNGGGC

NGTNN(^TAGGGNNANGNNTNCCTOSfTCCNCTCCCNNNTCTTNAGNCCCTATAGTGGAGT

GCGTATTACAANGGNGGACGCTCTAGCNNCTAGNGGCATCCCCCCGGGCCNGCAGGCNAT

CCTNCTCTAGGTNNCNNTTNNNNTNGACT^

NCCCCGCGGATGANNACTGNNTCCCATCTGNNTANTACCNCANGNNNTNCGCCTTNACNT

GGNCAGNCCNCNGGCCCNCGATCGNNTGANACAAGTGNGCTCTNNTGGTTGCNGGACNA

NCACACTGOSrTNNNANTNT(^CNTGNCA(_^CGCTNANACNNTNANANNGANTTTGCTGGN

ACANGCANTGNCCGTCATNNCNTNTNTGOW^

TN(-^CCGNAGCTTGTNTANGCCCAANTTCTTNNTNCTACCAGGGAGCNNANAANGNGGCC

TCTTNTGNTANNCAAGGNGNNTGNNATNNTGGGNCNCCGNCNNCCNNGTCCCGATGNGG

CACCTNCTNTNNTATTANGGTCATNTGA<^CNCCCCTGGGCGAACTTCTGAATCTNNNNN

NGNNAGNNTCCTNGGGACGCCNTAANANTNTANNCCCCCCNNTNNCTAGNAGAGGNNGN

TNC<^ANNACCNGCCTNANGGG<^GANOSrCGNNNGNAN^

CCGCCATTNGTCTNGNNAANGCTTACTCNNCANNNNACCTCGNCTGTCTTNNCTNCCNTG

NGCCNNGGNGNNGATCGCTNA<_MNGNN<^CCGGCAAGC

AANTNNCCCTGNTGCCCNNNNTNNN^

AGNNGαWCNNCNNGTTTTGNTCCCTTCCTTATGTGTCCCCTCTTCTTGCCCCCCNCCNTCG

CAATNGGANCNNTTGGCCNNNTGNNTATCANNTNCTCANTNNGGNANCCATACCCACNGA

NCA(^TAGAANNGTATATCTCANCNCNGNGCATTANTTNNNTTANCTTNCT(^TNNGANT

TNTCTACTNCGCTCTCATNNNTGCCNT(^CNTATTNTCATTAGNNCANAANCAOSfNTGNTG

ANTNOSfNTCMNNTNNCαsrCTCATANNNNNNCANCNTNCAGTCTCNGNCCACANNGC^

CGCTGTTNNNCNCNTGCGNANNCANNTNTNTNTCGTANCANTGANANGANGNTTATNNAC

TGTTTGTGTTCTATCTNAGNGCGNNNCGOSfCACANGNGGCTGNNACNNACATANANANNT

CNGCTCATNCGATGGNGNNGCCCTANCGANTGNNNANGCNCGCG

AACAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTTNAGNGTCCTCTTCAGCGACTCAGTACGGGGCTCATGAGCAGACACATGCGAT GTATGTTT< TACTGGTTCCTTNGTTAANAANNANNCNNNCCTNANGGCNACCTTGANCCN NNNNNTTCANANTCTTAANCNTTAANTNNCCCCANCGGANN^WAA^INAANNCNNNATGG

GGGGAACCATTCTNGGCCCAANNCTNGTNAACANCATTAACANCANGGCGGTTAAGNTTT TCATTTGGGCANNCCACANNANCANNCTGGCATTTAACATGNNGGGGTTGGCCAANCCCA CCTTTATNAACCTGGCTTAATANACACAGTCTACAGAAATATTTTTCCCAACAGNACANNC AGACACGTGTTTTACAATATCATACTNTTCATGTGTAAGANCGGGGNTNCACNNAATNTA CACCACATNGGGCATGTGCNTCNGAACAANCCCACCCCCAACAANNNNNTGTGAAGGGN

GTCTGGGGGAAACCNAAAGGGGAAAATCCTCTTCCTTTTATGGGTNTACAACTGGGAGCA CANAAAACTAGAAATTCTTNTTTTTGTTTGNAAAAANATATNTGGATNNNTTGTA ATAANAAGNNTGACAACTGACTTGTCGGNGGAAGAAAATTTGGACCNCCGTAGAAGGCC TTTTTTGAAAATTGTGGGNNGNTGCATAATAACAAAATGATGGTTGTCCAAAAACCCCCA AGGAACCCCAAαSTTTTGTTGGTGGNAAANTGGGAGATTTTTTTTTT^

AAAGGGNTTGANAAAACAAAATCATTTTTNTNAAAAAAAAAGTANCCANNAGGGGGTTT TTGGTTGGTTTTTACCGCCTNNAAAAAAAAAAAAAAAAAATTCHNGGGGGGGGGGNN AACAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTTNAGNGTCCTCTTCAGCGACTCAGTACGGGGCTCATGAGCAGACACATGCGAT GTATGTTTGNACTGGTTCCTTNGTTAANAANNANNO^NNCCTNANGGCNACCTTGANCCN NNNNNTTCANANTCTTAANCNTTAANTNNCCCCANCGGANNNNAANNAANNOSINNATG GGGGAACCATTCTNGGCCCAANNCTNGTNAACANCATTAACANCANGGCGGTTAAGNTTT

TCATTTGGGCANNCCACA πSfANCANNCTGGCATTTAACATGNNGGGGTTGGCCAANCCCA CCTTTATNAACCTGGCTTAATANACACAGTCTACAGAAATATTTTTCCCAACAGNACANNC AGACACGTGTTTTACAATATCATACTNTTCATGTGTAAGANCGGGGNTNCACNNAATNTA CACCACATNGGGCATGTGCNT(-^GAACAANCCCACCCCCAACAANNNNNTGTGAAGGGN GTCTGGGGGAAACαsrAAAGGGGAAAATCCTCTTCCTTTTATGGGTNTACAACTGGGAGCA

CANAAAACTAGAAATTCTTNTTTTTGTTTGNAAAAANATATNTGGATNNNTTGTACAA ATAANAAGNNTGACAACTGACTTGTCGGNGGAAGAAAATTTGGACCNCCGTAGAAGGCC TTTTTTGAAAATTGTGGGNNGNTGCATAATAACAAAATGATGGTTGTCCAAAAACCCCCA AGGAACCCCAACNTTTGTTGGTGGNAAANTGGGAGATTTTTTTTTTTTTAπ AAAGGGNTTGANAAAACAAAATCATTTTTNTNAAAAAAAAAGTANCCANNAGGGGGTTT

TTGGTTGGTTTTTACCGCCT WAAAAAAAAAAAAAAAAAATTCNNGGGGGGGGGGNN

TTNAAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGTTACACCCCACCCCCCAACATAAGGACAAGTCAGTTTGTCAGTAGCTTCCTCTG

GCTTGAACCCCCTCGATTTTTATAGCCCACTTAACCATGCATAACAGACAAGTCCCATATT TGTCAGTAGATGCCTTTTTTTTTTTTO^

AAAAAAAAAAIWCNNANCGGTTTANAAAANCNACTTAGGGCCTTGGAATNNAACTTTGG αSfTTGGNAANANATTACCTTTTNAGGNCCAAAGGGCCCCCGGGNNCCNCCCNAAAACCTT TGCCCCGGGGNGGGGGNGGGGGGGGGGGCATTTAAAAANANNANNTCCNTCCATNGGAA

AAAAAATNG^CTTTTC-OTTAATTTAAATTC^

GAGCCCCCACCCCCCCTTTGGGAANGTTNTTNCCAAATTTGGTTTTTTNGGGGAAACCTGN TTTGAAATTNAAAAACNTTTTTTTTTCCCAACCTGAAACCTTTGGGGG NGGGTTNNGGNANGGNCNNTSINAAAAAGGAAAAATGGNAAAACGGGGGANAAAAATTGG GNAAANAAAGGGGGAACTTTGGGAAAAAAAATTTTTTTTTT^^

AGGGGGAACTTTAANGGGNTTTTTAAAAAAAATTTTGTTTTTGGGGGGNNAAAAN^ CCCNTTNTTNNTGGGGGAATTTTTTNAAAAAANNCCCCCCCCAANNGGGGGGGAAAAGGT TTTNAAAAAAAAAAAACTTTTTNNGGGGGGGGGGAACNNNAAAAAGGGGGTTTTT^ CCAAAAAAAAAATTTmGGGGNAAAAANAAATTTTTTTGGNAAAAAAANNT^ GGGTTTTNGCCNNAAAAAAAACCGGGGGGNT

TTGANACAGCTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGCACCCCGTGCTGCTGACGGAGGCCCCTCTGAACCCCAAGGCCAACCGTGAGAAG ATGACCCAGATCATGTTCGAGACGTTCAACACTCCTGCCATGTATGTGGCCATCCAGGCTG

TGCTGTCTCTGTACGCCTCTGGCCGCACCACTGGCATTGTCATGGACTCTGGGGACGGGGT CACCCACACGGTGCCCATCTACGAGGGGTACGCCCTCCCCCACGCCATCCTGCGTCTGGAC CTGGCTGGCCGGGACCTGACAGACTACCTCATGAAGATCCTCACGGAACGTGGTTACAGC TTTACCACCACAGCCGAGCGGGAAATTGTGCGTGACATCAAGGAGAAGCTCTGCTACGTC GCCCTGGACTTCGAGCAGGAGATGGCTACCGCTGCATCCTCCTCCTCCTTGGAGAANACTA

TGAGCTGCCCGATGGTCANGTGATCACCATTGGCAATGAGCGGTTCCGGTGTCCCGANGC ACTCTTTCAGCCGTCCTTCTTGGGTATGGAGTCCTGGNGCATNCATGAAANCACCTTCAAC TTCATCATGAAGTGNGACGTGGACATCCGAAAGGACCTGTATGCCACACGGNGCTTGTTN GNGGGAACACCATTGTACCCTGGCTTCNTTGACAGGATCAAAAGGAAATACCGGGGCTGG GTTCCAΛGCCCGATGAAANATCAAGAATCTTTGGTTCTTCCCGAACGCCAAGTACCTCGG

GGGGGGATCGGGANGGTTCCATTCTTGGCCTTCCCTGGNCCNCCTTTCAAAAANAAGGNG GGTTCAACCCANCCCGGAANTTTGACCAAGTNTTGGGCCCCCTC(^TTTGGCCCCCCCGAA AANGCCTTTTTAAAAGGGACTNGGGAACCCAANAGCCTTTANANTTT

AAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCAGCCTTGTACCTTCATCACAACGAGATCCAGGAAGTGGGCA GTTCTATGAAAGGCCTCCGATCATTGATCTTGCTGGACCTGAGCTACAACCACCTTAGGAA GGTACCTGATGGACTGCCCTCAGCCCTTGAGCAGCTGTACCTGGAGCACAACAACGTCTTC TCAGTCCCCGACAGCTACTTCCGGGGGTCACCCAAGCTGCTGTATGTGCGGCTATCCCACA ACAGCCTCACCAACAATGGCCTGGCCTCAAATACCTTCAATTCCAGCAGCCTCCTTGAGCT GACCTCTCCTACAACCAGCTGCAGAAGATCCCCCCAGTCAGCACCAACCTGGAGAACCTC TACCTCCAAGGCAATAGGATCAATGAGTTCTCCATCAGCAGCTTCTGCACCGGGGTGGAT GTCATGAACTTCTCCAAGCTGCAGGTGCTGCGCCTGGATGGCAACGAGATCAAGCGCAGC

GCCATGCCCGNTGACGCGCCCCTNTGCCTGCGCCTGGCTAGCCTCATCGAGATCTGAGCGC CACTGGGCGCANGGCCATGCCCCCACGCCTNTTTGCATTTTGGCTTGATGGTTGGGTTTGG CTTTTGAATGGAAGGTCTGGGAACAANACCGTGTGACAAAAGGTCCATNGGGCTCTNTTT TTAAACCTTNTTNCCTGGAGGGCAGTTTTAGGGGGGGNCANGGGGAAAGGCCCCTTTTTπ GTTGGGGGGGAAAATGAANCCCTTCCGTTTTCCAAAAAAAAAAAAANGGTTTGGGAAAA

AAGGGGTNAAAACCCCTGGAAAGTCCCCAGTCCCCCCGAAAANTTTNNTTTACCCCTTAA NGGGTTTTTTCAAAGGGGAATCCAAGNNGCCTTGNAACCCNTTGGCCTNGGAANNAANAA AAAAAAAACTGN

AAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GGTAAACCCAAGCCCTTGACCTCTTACAGGAGCTTTGTCTGCCCTCTTAATAACATCCGGC CTAACCATGTGATTTCACTTTAACTCAATGACCCTGCTAATAATTGGCCTAACAACAAATA TACTAACAATATACCAATGATGACGAGATGTTATCCGAGAAAGCACCTTCCAAGGGCACC ATACCCCAGCTGTCCAAAAAGGCCTCCGTTATGGAATAATTCTTTTTATTATCTCCGAAGT

ACTATTCTTTACCGGATTTTTCTGAGCTTTCTACCACTCAAGCCTCGCCCCCACCCCTGAAC TAGGCGGCTGCTGACCCCCAACAGGCATTCACCCACTAAACCCCCTAGAAGTCCCACTGC TCAACACCTCTGTCCTATTGGCTTCCGGAGTTTCTATTACCTGAGCCCATCATAGTTTAATA GAAGGGGACCGAAAGCATATATTACAAGCCCTATTTATCACCATCACATTAGGAGTCTAC TTCACACTACTACAAGCCTCAGAATACTATGAAGCACCTTTTACTATCTCCGACGGAGTTT

ACGGCTCAACTTTTTTTGTAGCCACAGGCTTNCACGGNCTTCCACGTCATCANTGGGGTCC ACCTTCΓΓAATTGGCTGGCTTCTTTCCGCCAATTAAAANTTCANTTTACTTCTAACCACCAC TTTNGGTTTTGAAAGCCCCTGGCCTGGAACTGGAANTTTCGGAAAACGTANNCCGGACTTT TCCCTCTATGGTNCTATCCAATGGGGGAAGGCTCCTNAAAANNNANNNNNNNNNNNNNN NNNNNNNNNNNNNNNNN

GGGGGG

AAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGCCCGAGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCTCCGGGCTCCTGCTAAGCC

AGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTACCGGGACCTCATTAGCCA TGACGAGATGTTCTCCGACATCTACAAGATCCGGGAGGTCGCGGACGGGCTGTGTCTGGA GGTGGAGGGGAAGATGGTCAGTAGGACAGAGGGTAACATCGATGACTCGCTCATTGGTG GAAATGCCTCCGCTGAAGGCCCCGAGGGCGAAGGTACCGAAAGCACAGTAATCACTGGT GTCGATATTGTCATGAACCATCACTTGCAGGAAACCAGCTTCACAAAAGAAGCCTACAAG

AAGTACATCAAAGATTACATGAAGTCAATCAAAGGGAAACTTGAAGAACAGAGACCAGA AAGAGTAAAACCTTTTATGACAGGGGCTGCAGAACAAATCAAGCACATCCTTGCTAATTT CAAAAACTATCAGTTCTTTATTGGTGAAAACATGAATCCAGATGGCATGGTTGCTCTGCTG GACTACCGTGAGGATGGTGTAACCCCATATATGATTTTCTTTAAGGATGGTTTAGAGATGG AAAAATGTTAACAAAGTTGGCAGTTACTTTGGATCAATCACCTGTCGTCATAACTGGCTGG

CTACTGCTTTTCATCCACACAACACCAGGACTTANACAGATGGGACTGATGTCATCTCGAG CTCTTTCATTTTGTTTTTGAACCGTTTGATTTATTTTGGAAGCGGAN^ AAAAAACGTGGTCNTTGTAGGTTGNCTAAAAAATAAAACCGCANTTTAACTCAAAAAAAA AAAAAAAAAAAANTTCGNGGGGGGGGCCGGNTCCCCAATTNNCCCTTTTTNNGGNGGNN NNNTNTTITATNNNNNNNNTSfNNNNNNNN^

NCCTATNNGGAGNNNCATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCNGNCCCGAGGCTTAATCAGTGGTGGGAΛGAACGGTCTCAGAACTGTTTGTC TCAATTGGCCATTTAAGTTTAATAGTAAAANACTGGTTAATGATAACAATGCNTCGTAAA

ACCTTCANAAGGAAAGGANAATGTTTTTGTGGACCATATGTTTTGNGNGTGGCAGTTTAA GTTATTAGTTTTTAAAATCAGTNCTTTTTAATGAAANCAACTTGACCAAAAATCTGT^ NAATTTGAAACCCATTAAAAAAAAAAAAAAAAAACNNGGGGGGGGGCCCNGGCCCCNAT TNCCCCNTATNGGGNGNNTNTTNACANNNNNNNOSπ^NNNNNN^ NNTNNNNTCTNNCNNNNNOSINNTCNNNNCNNNNNCNNA

N^INN N NTNΑ [ NNCTNTTTCNNNR W

CASLNNTNCCNNNTNACCTNNTOSINNNNTCNNNNNCTCTNA

CCNNNCTNTTNNNGNCNNANNNNNT^^ NCWΪNTTNNTNNTCQWNNNCCN^

NTNNNNNNNTNCCTNNNNTNTCNANNNTNTCNNTCTCCNNNNCTN^

NCTNTTNCN SINNTCNNNNNNNCCCNNNCTCNTNNNNNNTC^

NNNNTCNNNNNCCTCNNNC^

TCNTNNNNTNNNTNNNTNCOSTNNNNNNTTACCTNN NTNTNNCMNΠSINNNNNC(^TNTNCCNNNTNNNCTTCTNT^

CCTCN

TCGNGNTAGGGGNGGATNGCNCNNATNGCCTCTNTTACCCANTCGNAGNCNTAATNNGGA GNCTNCACCNCAGTGGCAGGCACGCTGCTNGNANCNAGTGNGTNCTCAAANCGGTCATGC

NCTAAATGNCCGCTCGAGGCCATTTTTTNTCTNTNTNACNTNGGCGNTATNCTGNTCCGGN G(^GNNGAGGCCNCNACCTGNAGAAGCANCNGTNNTTGNTCTNATCAGAACTTTNANTAN NCCGGCTGTNCTGNA(^ANNTTACACTNGC^GTGNTACTGCNANTNTNNGGCATTTNTNG ANTCGTASRCANNCTAAGGTATAGAANGNCGGNGTCGTATTANTGTCNTTGTTAATGGACN AAGTNNCGNCNNAGGGANTACNCGGCTTTANGGGOSFGGTTGGANNCTNAANCCTTNGNT

NNANTGNTTNGGNCN(^ATCCNNTGTATNNGNNTCCNNTAGTNTNCNTCNNNNGNTTTCT TGNNAANTGNGN(^ATCTACTNAGTNCGGCCNGGGNGGATANCTNTNTNANCTGTTTACG CTCTNNGACNCCGNNNNNTGTCAAAGTTTTGGANTGCCTNNTACTCCCANNCANGATGNG CGNNTNNACCNCCCAANTNTNNNGTAGGNACCCANCOSINGAGCACTNTNTTNTNCNTTAA NNNTCACCNCGCNCTNGNNCAGGGTNTTNNNNANANGNTGGGNNNCOWACNTNACAGT

GGATNCTNACATCTGTCNCCACTNCTTGANNNTGNNCNTTTGTNCCGGGNAGNTTNACNC NTGNGGGGNTNAAAGGNATNTTNCNTACCACNTGNNTNTCTGGANTGGCGCNCNTTACAA ATCTGNNAGTNNCGCTTGNGGNNACCNCCAGGGGNAAANTTNNNNNNGNTTGNGNNTNA NTNGGNAANGCNCNTTCNCATNTNNCCCCCGNATACCCNNTTTACTNTTTCNTTTTACTTA TAANTTTNTACTNCTATGANNTTCACCNNGNNCTAGCAATNANAATAGNGCNTANNTNTC

AGGNGCNACCNGCCNNTGGGTCGANTCTNTCANNATATCGCTANNANTATATNTCNGCAN ANNCTTCTNGCGGAAA(^TATCGGCGCGNNTNANNNNTGTATCTNCNTNNNCANATAACT CTNAGTTGCNGTGCNGNGTNNTGTTANNCTANATNNNCNGTGTAAATNNCNGCNCANTCC NNTGGTNCCGTANGGTCTTNGAGTACAACTANTGCNNCNGTTNGCTTGGACGTTCTCNNC NTANNNCTGTAGNANAANNTCGCAGNTANTNNTTNANACNNGTATAGANAATTACTCNCA

TTATCGNNTNANNNATNGANATTNGTNGTNCGTCTNNNTANATTCGANGANTNTTGCANG NTTNTNTNATANATAGACGATAGNGTNANGAGTCN

NCAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAANTTCGGCACGAGGCCTGGAGCATGAAGCCCGGAACTGCATGAACCGCTCAAA ACAGGTCTTCACGTGCTCTGTGTGCCAGGAAACGTTCCGCCGNAGGATGGANNTGCGGNN GCNCNTGGNGTCCNANNCGGGGNAAANNCCTTACAAGNNNTCNTCNTGTTCCNANNANTT ANTNCAAAAAANGGACNNGCAAANCQ^NNTNATNAACTTGNNCGNACCCCCNANCCCCA TNNCTNGNCCAACNNGNNasrANNGNNTTCTNGTCCNGANCGNACTTGNACTNGCCAAGG

GTTNAANCACa«JTGNGGGAGAAATGTTTGTGTGCCAAGAGATGCGCGGCACACNGCATCT AGCCCCGNATGTGGNTTGNNATATGCATCTCAGGGCCAGCACACAGAGACGAGAGNGGC ATANACTGTGTGAGANTTTTNGANACNOSICTTTCACANAAAGGGCNTATCTAAATGTGCN TGTGCACACGCACANGGGAGAAAANCTTTNACNGGNCσSfNTTNTGGGAAAAGATTTTGCA CCAANANAGAGTTGTGGAAAAACACACGCGCC(^CACNGGCGAGAAGACCTTTTTCATGT

GAGATTTGTGAGAACGCTTTTCANAAAAAGNGGGCCTTCTTCATGAAATGTTGTCCANCN CCCC(^CCAACAAGGNGGNGCCCC(^CTTNTTTTAGNANAATGTTGGGAAGAAACTTTTT ANATTGGTGGAGGAAACTTCTTCNTCCNCCTNAANGAAANAAAACAACGGGGGGGGANG NAAGGAACCNNCNGGCCCCNCAATTGATGGGTTACNAANNNANNCCCCCGCCNGGGGCC CCCCCTTCCTGGGGGGGGGGCNNGGANGANACATTCCCCCGGGCNGGGGGGNAAAAAAA

AAC(^CCCNNNNGGGNNAANNNTTNTTTNAATTT NCAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAANTTCGGCACGAGGCCTGGAGCATGAAGCCCGGAACTGCATGAACCGCTCAAA ACAGGTCTTCACGTGCTCTGTGTGCCAGGAAACGTTCCGCCGNAGGATGGANNTGCGGNN G(^CNTGGNGTCCNANNCGGGGNAAANNCCTTACAAGNNNTCNTCNTGTTCCNANNANTT ANTNCAAAAAANGGACNNGCAAANCCNNNTNATNAACTTGNNCGNACCCCCNANCCCCA

TNNCTNGNCCAACNNGNNCNANNGNNTTCTNGTCCNGANCGNACTTGNACTNGCCAAGG GTTNAANCAC(^TGNGGGAGAAATGTTTGTGTGCCAAGAGATGCGCGGCACACNGCATCT AGCCCCGNATGTGGNTTGNNATATGCATCTCAGGGCCAGCACACAGAGACGAGAGNGGC ATANACTGTGTGAGANTTTTNGANACNCNCTTTCACANAAAGGGCNTATCTAAATGTGCN TGTGCACACGCACANGGGAGAAAANCTTTNACNGGNCαSINTTNTGGGAAAAGATTTTGCA

CCAANANAGAGTTGTGGAAAAACACACGCGCCCNCACNGGCGAGAAGACCTTTTTCATGT GAGATTTGTGAGAACGCTTTTCANAAAAAGNGGGCCTTCTTCATGAAATGTTGTCCANCN CCCCCNCCAACAAGGNGGNGCCCCCNCTTNTTTTAGNANAATGTTGGGAAGAAACTTTTT ANATTGGTGGAGGAAACTTCTTCNTCCNCCTNAANGAAANAAAACAACGGGGGGGGANG NAAGGAACCNNCNGGCCCCNCAATTGATGGGTTACNAANNNANNCCCCCGCCNGGGGCC

CCCCCTTCCTGGGGGGGGGGCNNGGANGANACATTCCCCCGGGCNGGGGGGNAAAAAAA AAC(^CCCNNNNGGGNNAANNNTTNTTTNAATTT

TTNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGTTACACCCCACCCCCCAACATAAGGACAAGTCAGTTTGTCAGTAGCTTCCTCT GGCTTGAACCCCCTCGATTTTTATAGCCCACTTAACCATGCATAACAGACAAGTCCCATAT TTGTCAGTAGATGCCTTTTTTTTTTTTNCCCCCCCNGGNTTAANCCTTA^ NAAAAAAAAAAGNCGNANCCGNTTANNAAACCNACTTAGGGCCTTGGAATTNAACTTTG GC CTGGGANTAACTTACCTTTTNAGNNCCAAANGGCCCCCGGGAGCCTCCCCAAANCCT

TTGNCCCGGGGAGGGGGNGGGGGGGGGGGCATNTAAAAANAAGANNTCCCTTCATTGGG AAAAAAATNGGCCCTTTTNTTAATTTAAATTTO^

GNGCCCCCAACCCCCCTTTGGGAAAATTGTTGCCAAAATTGGGTTTTTGGGGAAACCTGNT TTGANATTNAAAACCTTTTTTTTTTCCCACCCGAACCTTTGGGGAA^ GTTCGGGGAGGGNNCCAAGAAAGGAAAACTGCCAAAACCGGGNANAAAAATTGGGAAA

NAAAGGGGGACCTTTGGGAANAAAAATTTTTTTTTTΓΓTΓAA^ AACTTAAANGGGCCTTTTNAAAAAATTTGTTTC^

TTTGGGGAACTTTTTTAAAAAANNNCCCCCC<^AAANGGGNAGNAAAAGGNTTTAAAAA AAAAAAAACTTNTNGGGGGGGGGGAACMSINAAAAGGGGGTTTTTTTTT ANATTTTTGGGGNAAAAAAAAATTTTTTTTGGG^

GNNNNAAAAAAAACCCGGGGGGT

TTGGANACCACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCNCCCGGG CTGCAGGTTAAGGAAGTCAGCACCTACATTAAGAAAATTGGCTACAACCCCGACACGGTA

GCATTTGTGCCAATTTCTGGCTGGAATGGTGACAACATGCTANAACCAAGTGCTAATATGC CATGGTTCAAGGGATGGAAAGTCACACGCNATGNCTGGCNTTNCNANNNGAANCNCNNT GCTTGAACCTNTNGATTGCTTTATGGCAGNAACTGGCCCNATNNACAAACCNTTNTGTTTG C^TCTCCAGGATTNCTATAAATTTGGTTGGNATNGGNACTGNNCTTGTGGTTCTGNGTNTA GANATGGTGTTTTNAAANCTGGCATGGTNGGNCACCTTTNGCTCCAANAACTGTANCANC

TGNAGCTGAAAGNTTTTANGAANTGCNCCATGAAAACANTGAGTGANCCCCTTGGNTGTG GACTATGTNTNTCTTATANTGNGNAAAAAACGNGNNNTTTCAACANATGGNCCGAANTNN NNANNNTTTGCTTNNTNATCNGAAAAAANTTATNCANCCα QSfTNGNAACCT^ TCNNNGNNTTNAGCGGNTTATTTNTGAAACCATTNNTTGGGCNATTTTANNTG NNTTCCCCCCTAGNGGTTGGGANTNGNCACTA(_ GCTT^

GNNTTGAGNTTNAAGNATAAANAATTGANTC(^TTTTTNCTNNGNAAAAACAGANTπ AAGAAATGGGCCTTATNTTNCTNTNNAAANCTNGNTNGACACCCNCCCTTmTCTCTTNT^ TTGNATCCTNGTGATNTTCCNACTTCNTC^^ TCCCGTGNNNCCTO«MNTNNCTAT WTGACCTCCTCNATTGGAAACTACNCTCTTACNNTC TTNTTATTAGCNCTATTATNAGTNTTGTGTCTANTNTCTANCGCGTTTTTGAGATTACTNGN

AATTTCNTTNCNNACTNNTTGTCCT CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAAAAAAGTCAGAAGTAGCAGTGCCACCATGGGTTGATAGTAATGATGAAGAAACA

ATTCAACAACAAATCTTGGCCCTGTCAGCTGACAAGAGGAACTTCCTTCGTGACCCTCCAG

CCGGGGTGCAGTTTAACTTTGACTTTGATCAGATGTATCCCGTCGCACTGGTCATGCTCCA AGAGGATGAGCTCCTGAGCAGGATGAGATTTGACCTTGTTCCTAAACTTGTGAAGGAAGA

CGTGTTTTGGAGGAACTACTTCTACCGTGTCTCCCTAATTAAGCAGTCGGCCCAGCTCACA

GCCCTGGCAGCCCAGCAGCAGGCTGCTGGGAAGGAGGAGAAGAACCACGGCAGACAGAA

TGAGTTGCCGCTGACAGAGGCAGTACGGCCCAAAACACCACCTGTCGTAATCAAATCTCA

GCTTAAAACTCAAGAGGACGAAGAGGAGATTTCTACCAGCCCATGTGTTTCTGAGTTTGTC AGTGATGCCTTCGATTCCTGTAACTTAGATCAGGAGGATCTGAGGAAGGAAATGGAGCAG

CTGGTGCTGGACAAAAAAGAGGAGGGGACAGTCGCACTGGAAGAGGATTCTGTAGATTG

GGAGAAAGAACTACAACAGGAACTTCAGGAATATGAAGTGGTGGCAGAATCAGAANAAA

CGAGATGAAAACTTGGGATAAGGAAATAGAGGAAATGCTTGAAGGAGGAAAAATAAACT

GTTTGTTTCCTGAAANAAAANAAANAACTGNAACCTTGCCTNTAACTGGCATTTAAATTTN TANAGTTGANAACTCNCTGAAATCAAAAGGGGCCAANGGAATTTACNTTTNTAAAATTCA

_A^_Aτrrrrπ

TTNNNNAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCCGAGCGCCGCTCTGGCCGCACTGCGCTCGCCCTGAGCT

CCGGGCTCCTGCTAAGCCAGCGCCGCTGTCGCCTCCCTCCAGTCGCCATCATGATCATCTA CCGGGACCTCATTAGCCATGACGAGATGTTCTCCCGACATCTACAAGATCCGGGAGGTCG CGGACGGGCTGTGTCTGGAGGTGGAGGGGAAGATGGTCAGTAGGACAGAGGGTAACATC GATGACTCGCTCATTGGTGGAAATGCCTCCGCTGAAGGCCCCGAGGGCGAAGGTACCGAA AGCACAGTAATCACTGGTGTCGATATTGTCATGAACCATCACTTGCAGGAAACCAGCTTC

ACAAAAGAANCCTACAAGAAGTACATCAAAGATTACNTGAAGTCAATCAAAGGGAAACT TGAAGAACAGAGACCAGAAAGAGTAAAACCTTTTATGACAGGGGCTGCAGAACAAATCA AGCACATCCTTGCTAATTTCAAAAACTATCAGTTCTTTATTGGTGAAAACATGAATCCANA TGGCATGGNTGCTCTTGCTTGGACTACCGNGAGGATGGGGTAACCCCATATATGAATTTTN TTTAAGGATGGTTAAAAAATGGGAAAAATGTTAACCAAAGTTGGCAGTTACTTTTGGATC

AATCACCTGTCGGCATAACTGGGCTGGGTTACTGGTTTTNATTCCCCCCAACACCCNGGAC TTAAAACAGAANGGGAACTGGATGNCANTNTNCAAGCCTNTTTANTTTGNTTTTGAAACG TTGAATTTATTTTGGGAGCGGGGNGGCNTTTGGTTTTTTGANAAAAAACGGGGTCATNGG ANGGTTGGGCTTAAAAAAAAAAAACCCCTT

CCTATCTGGAGCTNCANCNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCNGCACNAGGTGTANNCNGGCCNCCNTTCAGCNCATGTGCCNNCCGNNANTGG NCATCTCCTGACTCCATGATTGCATGCTGGCTATTACATGNNCCCTGTGAGGNAGTCACNA

CCTCTNACACNGCTAACAGACTNGANGATGAGGCCNTNNGCCCACTTTACCTGANNTTGT GNTCNGNCNTNANGTAGNAACCACATGCCCAATGNNTCATAGCCCTGGCTANNAGAACA NGNACGACCTGNGCCAANANAGGACCTTTNCTNACGTGATNTNAGGAGGGCAGGGNTTC GANACTTTCTATATNNTATAGCACTTGTTNNGTTGCCTCTGCTCACCTNACNGAATATNAA AANTNNATCNGTGNGAGNGAAAGTCNGCTCGNATNGNATTCNTTGATTGATCANGTNATT

TGGGCTNCATCCCTTGNAANTAANGAGCTGTGCTATCNTTGTNCNACTGTNTTTACANACN NAATANCNATCTGTTNNNCCGGNATGCaSTGCATTATTTTTGAATNAAANCTNT WTT^ ANNTNGNTGGATCCNGACTNCNNGCGNNCGAACCNNNTTGNANTNGCTNTAATGCGGGA NTGTNNTAGCCAAAAANTNCGGGNTTNANTCNTCTTTATTTCTTNNACCGCTTNGGANCCT NGTTGCCTCTATGGCTNTTTGNNTGNC^^

CGNGAONCCTTTNNNNAGATTNACCCTNGTNCTasrGNNAANNNTAATTTCATNCNA^ NTTCCCTTTGAAGCCNTTNTTTTGCNACCCCCTTTGGNANGGCNNTTNGNTT^ AAATGGNANGTC3S1NTCNGGACCCCCAAAATACTAAAAAAANTGGTGTGNACTGTTTCTAT CTAACTNNTACAGNATCCCTTTTTGAGANGCGNNNACCGGCAANMWGNTCNCCNCTTTT ATGAAσsπSITGGATTNTTTTGGCNNTTANTGGCT

NCCTATNNGGAGNNNNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTT GCAGGAATTTCGGNNCGAGGGCCGGGCCTCTCAGAAACATCACATATCACTNGCAAGAAT AGCATTGCATACATGGATCATGCCAGNGGNANTGTAAANAANGCCTTGAANCTGANGGG GTCAAANGAAGGTGAATTCAAGGNTGANGGAANTANCAAATTCCCNTNCCCAGTTNTGGA GGATGGTNGCCCAAAACACACTGGGGAANGGGGCAAAACAGNNTTCCAGTATCAAACNC CCAAGGCCGTCAAACTACCTATTGNAAATATTGCNCCCTATGATATCGGGGGCCTGANCA AAAATTNGGGGNGNAαSTTTGCCCTNTTTGNTTTTTATAANCCAAACTNTATCCAAAGTCCC

ANAAAAAGCTTCACACNCCATATGNCCCTTNTGCTCNAATCNTGGCCCCAGNACAAGTGA CCAAGTNCCAGTTNTTTTTTCCCTGANATCGAGGGTCTCAAAGGCCAAGAGGGCTTCCCTG GNGGCTGNCATCTGNTGACTCTGAACAGNGTGGAGAGATGGCTGTTAAAGATCTCACGCC ANNCTGGCCCCNTCTGGACGCCTNTCTGAAGAACCCCCACANGACATGGCGCGGTTCTGC GCGAANACCANGNCTTATGAATGTCCCGCNCCCCNGGNCGTGAANGANCCCCCCCACAAG

AAANCTGTTGGANNGCGAAAAAANCCCTGNTGTNTTTTNNNATCCCCAAAATTNNTTTπ CCCCCANAACCNCCGGTNGCNTNNGGGGGGGNGGATTTNCTTCTTCCTAAANNNNCCCCT TGNTTTAAANACNANNCCNNGGCCCCGGTTTTTTTNNNCCGANCNAANNNCCANGGGTπ NNNCCCNNNNAAAAAGAAAAGGNTCCNCCT

GCCCTANCTGGAGCTNCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTCAACATGACTGACAATGATCTTATCAATATTCTTGACCCTTTTTATCATCTTTCA ACTAAAAGTTTCAAAACACAACTTTTATCACAATCCAGAACTGACACCAACAAAAATATT

AAAACNAAACNCCCCTTGGGAAACAAAATGAACGAAAATTTATTTACCTCTTTTATTACCC CTGNAATTTTAGGNCTCCCTNTCGTAACCCTTATCGNACTATTCCCAAGCCTACTATTCCC AACATCAAACCGACTAGTAAGCAATCGCTTTGNAACCCTCCAACAATGAATACTTCAACT TGGATCAAAACAAATAATGAGTATCCACAATTCTAAAGGACAAACATGAACATTAATATT AATATCTCTGATCCTATTTATTGGATCAACAAACCTACTAGGCCTATTACCCCATTCATTCA

CACCAACAACACAACTATCAATAAACCTAGGCATAGCCATCCCCCTGTGAGCAGGAGCCG TAATTACAGGATTCCGCAATAAAACTAAAGCATCACTTGCCCATTTCTTACCACAAGGAAC ACCCACTCCACTAATCCCAATACTAGTAATTATTGAAACTATCAGCCTTTTTATTCAACCT ATAGCCCTCGCCGTGCGGNGGAACAGCTANCATCACTGCAGGACACCTATTAATTCACCT AATCGGGAGGAGCTACACTTGCACTAATAAGCCATTAGCACTACAACCAGCTCTTAATTA

CATTCACCATTCTAATCCTACTAACCAATTCTAGAGGTTGCAGTAGCTTATAATTCCAAGG CCTATGGATTCACCTCTTCTAAGTCAGGNCCTATTNTCTTGCTTGGACAΛCCCCCTTTNNN NNAAANNNNM^NNNNNGNNNNGC

NNNTATNTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGNNCNNATGACNATCNTGNTGTTNTNATNGTCTGANGCNNTNTCCGGGGTGNNNNNN

TTTNTNTTACTTACNNGTANCCNGNCCCCCCNTCCNGTGNNGGGTGGCCTNNCCCANAAA ANCTTGGNAAAAAACAAGGTNNACCTTTNTS[NCCTTGAANGCCTGGAANCCNGNNCCTTTT

CCNNCCNCNNGGAα^TTGNCAAAANNTGGNGAANACNNGGNTNTTAAAATNGNAATGNA CTG(^CCCCNTTNANNGTTAAAGGGNNGACNTAATTNTNNGTTGTGTCTαsrACTTTATACA (^CCNCATTTATAGGCCGGGGCNCNTNCACAAAACCCCGGGNACAGGGNGNGAGGGCCN CANATNNCCCGNGCNANANTCACACACTCCCCCCTTTGNATNNATGGGCANATGNTGTGT TTCCTNTCCNNGTGCGCNAGTGCATGTGCNCNCNTCTNTATATACCNTGGCTCNANNAGGT

GGCNNTATNANAATTTATNACCGTTTTTGNATNNGACAATGTNGCAGNAANNTACTGCTG NTTATCAGACTGCTTGTGGGGGCNNCAANAATCATNTTACTCTNGNGACCCCCCGANGAA CAGGGGGGGGCCCCCTTCTCITTNATTNNTCTTN^ NCCCCCCTTCATTNNNANNAANTTNGNGNOslNTAANAAAAAAAAAAAAAAANNGGGNGG GGGGGGGGGGGGGGGCCCCCTTC(^TCCCTTTTTTTCCCN^

NANAAGAANNTTTOTOWGAANAAA^ TTTTC

NNNTATNTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGNNCNNATGACNATCNTGNTGTTNTNATNGTCTGANGOWTNTCCGGGGTGNNNNNN TTTNTNTTACTTAOSπsrGTANCC^^

TNGCCNATTTTTNTTNGGGNCCNNAAAGGGNCANNNGGNATAAANGCCANNT JNNTGNC ANCTTGGNAAAAAACAAGGTNNACCTTTNNNCCTTGAANGCCTGGAANCCNGNNCCTTTT CCNTSΓCCNCNNGGACNTTGNCAAAANNTGGNGAANACNNGGNTNTTAAAATNGNAATGNA CTGCNCCC<^TTNANNGTTAAAGGGNNGACNTAATTNTNNGTTGTGTCTCNACTTTATACA

CNC(^CATTTATAGGCCGGGGCNCNTNCACAAAACCCCGGGNACAGGGNGNGAGGGCCN CANATNNCCCGNGCNANANTCACACACTCCCCCCTTTGNATNNATGGGCANATGNTGTGT TTCCTNTC(_MNGTGCGCNAGTGCATGTGCNαS[CNTCTNTATATACCNTGGCTCNANNAGGT

GGαsπSTTATNANAATTTATNACCGTTTTTGNATNNGACAATGTNGCAGNAANNTACTGCTG NTTATCAGACTGCTTGTGGGGGCNNCAANAATCATNTTACTCTNGNGACCCCCCGANGAA CAGGGGGGGGCCCCCTTCTCTTTNATTNNTCTTNGGGAGGGCNCCCTTNTTNNT^ NCCCCCCTTCATTNNNANNAANTTNGNGNσSTNTAANAAAAAAAAAAAAAAANNGGGNGG

NANAAGAANNTTTCNTNNGAANAAAAANACCCCNNANNGGNGANANANACNNTTTTNπ TTTTC

TTGAANAACNNTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGAATTCGNCACGAGGCNTTANTACAGGNTCGGTCTNCTTGCCATNNTCTTG GGTCTGαSfTNANACCCATTAGGTTNANATAGANCACTTACACGNGNNTAACCTATGCCNC α^NNATNTTTNACANOSINNNCNTACTTCTNTNGNCCCCGCTNCCGNATAANCT^ TTTTCCCGAGTGGNCAGCACCTTGNANCTTTCNNGNCGGCCTGNGCNCCGGCNTNANCNT GGATGGAAACNACGGTGGGGGCCCCCTGTTTGGGGGGCATTACAACTGTTTCCGTTAACC

CAAAGCCTGGTTGACCCCCNTTAAGCTGGANGGGGAATNCCNANATCCANGGCCGNCCGN CCCCANGNNAAGGGANCCNATTAATGACCCCTTNNANAANAAAATTTNNCCTTCTTTATT GGANAAAAGGGGCCGGGTNCCTNGGNNCNNNCANAAACCAGGNTTTTGGGANACCNAAN TGGAANCCTTTCTTNCANNNNCNANGAAAAACTNGGCCCGGAANNAANATTANAANNAT NTTTNNTTTGNNAANNTNNCATT^

CCNCGNAGAAAACmTAAAATTNGNAANTNNNAAACT^

TTGNGGGGGGGACCTTCTANNNANCCAANTTTTNGGGGTTNNAAATCCCCAAANNCCCNC CNANACCNTTGGNAAAAAGGNNTTNTTNANAATNAAAAAAANGNNNNNNNANAAAACNT TCTNNNNAAACCGGGGAAACNTNNNNANNCCCCCCCT^^ NNNTNNNNNNTTTTAAAAAANGNTTTTTTT^

NNTTTNNAANTTTTNTGACCNCCTCCCNNGGGGNTTCTCTTTCTTTGNC NTCCNNNGGNCTTNNGANGGNGNCNTTTTCT

TTNAACAANAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGTTAAGGAAGTCAGCACCTATTTAAGAAAATTGGCTACAACCCCGACACAGT AGCATTTGTGCCAATTTCTGGCTGGAATGGTGACAACATGCTAGAACCAAGTGCTAATAT GCCATGGTTCAAGGGATGGAAAGTCACCCGTAAGGACGGCAATGCCAGTGGAACCACCCT GCTTGAAGCTCTGGATTGCATTCTGCCACCAACTCGCCCAACTGACAAACCCTTGCGTTTG CCTCTCCAGGATGTCTATAAAATTGGTGGTATTGGTACTGTCCCTGTGGGTCGTGTGGAGA

CTGGTGTTCTCAAACCTGGCATGGGTGGTCACCTTTGCTCCAGTCAATGTAACAACTGAAG TGAAGTCTGTAGAAATGCACCATGAAGCATTGAGTGAAGCCCTTCCTGGGGACAATGTGG CTTTAATGTCAAAAACGTGTCTGTCAAAGATGTCCGTCGTGGCAATGTGGCTGGTGACAGC AAAAATGATCCACCCATGGAAGCTGCTGCTTCACAGCTCAAGTGATTATTTTGAACCATCC AGGCCAAATCAAGTGCTGGATATGCACCTGGGCTGGATTGTCACACAGCTTACATTTGCTT

GCAAGTTTGCTTGAACTGAANGAAAAAAATTGGATCGTCGNTCTGGGGAAAAAACTGGNA ANAAGGNCCCTAAAATTNTTGAAATCTGGNGACNCTTGCCATCGNTGGAAATGGGTNCCT GGCNAANCCCCTTGGNGGGOS[AANAACTTTTTTTTAANTATNCCTCCCCTTGGGNCCGGTT TTTGCTTGGGCCGGGAAATTGAAAAAAAAAAANNαSfNTTGGGGGGGNGGNAATNNAAAN Nα^NNNGGGACAAAAAAAGGCNANNTTGGAAACTTGGCNAAGGGCCCCCAAANTTTTGC

CCA

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGTTAAGGAAGTCAGCACCTATATTAAGAAAATTGGCTACAACCCCGACACAGTAGCAT

TTGTGCCAATTTCTGGCTGGAATGGTGACAACATGCTAGAACCAAGTGCTAATATGCCATG GTTCAAGGGATGGAAAGTCACCCGTAAGGACGGCAATGCCAGTGGAACCACCCTGCTTGA AGCTCTGGATTGCATTCTGCCACCAACTCGCCCAACTGACAAACCCTTGCGTTTGCCTCTC CAGGATGTCTATAAAATTGGTGGTATTGGTACTGTCCCTGTGGGTCGTGTGGAGACTGGTG TTCTCAAACCTGGCATGGTGGTCACCTTTGCTCCAGTCAATGTAACAACTGAAGTGAAGTC TGTAGAAATGCACCATGAAGCATTGAGTGAAGCCCTTCCTGGGGACAATGTGGGCTTTAA TGTCAAAAACGTGTCTGTCAAAGATGTCCGTCGTGGCAATGTGGCTGGTGACAGCAAAAA TGATCCACCCATGGAAGCTGCTGGCTTTCACAGCTCANGTGATTATTTTGAACCATCCAGG CCAAATCAGNGCTGGATATGCACCTGTGCTGGATTGTCACACAGCTCACATTGCTTGCAAG

TTTGCTGAACTGAAGGANAAAAATTGATCGTCGTTCTGGGAAAAAGCCTGGAANATGGNC CCTAAATTTNTTGAAAATTGGGGGACCCCTGCCATCGTTGGATATGGGTCCTGGGCAAAG CCCCATTGTGGGTCGNAAAG(^TTNTTTTGAATTATNCCCCCCCCTNGGGCCCGTTTTTGG TTGGGCGTGAAAATGGAAAAANAAAAAANNTNCNTTTTNGGGTGTCTTTAAAAACCGGGG GGAAAAAAAAAGGCANCTTTGGGACCTTGGNAAAGGNNαsrCCCAAATTTTGNCCCAAAA

AAAN

TTNANCAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCCGANGTCNNACGCGCGAGGCTGCTCTGCCGCCGCTGAN

ATGCGTNACGTTGCCTCCTACTTGTNGGCCGCCCTCNGGGGCNACTCCTCCCNCANNGCCA AGGACATNAAAAAGATCCTGGACAGTGTGGGCATCTAGGCAGACGACGATCGGCTCAAC ANGGNCATCANNGAGCTCCACGGAAAGAACATCNAGGGACGTCATTGCTCANGGTATCG GCAAGCTGGCCAGTGTGCCGGCTGGTGGGGCTGTGGCCGTCTNCGNTGCCCCAGGATCGG CAGCACCCGCTGNGGGTNCTGNTCCAGCCGCAGCAGANGANAAGANNGANGAGAANAAG

GAANANCCGGAGGAGTGAGATGATNACANGGNCTTCGGCTNGTTTGACTANAGTCCCGCT CCTCTGCACANAAAACCNTTTITATGTAGGANACTTATTACANNANNNNNNTGGGGGGGG NCCCAACCCNNCCATTACNNTATTGGNCNGTTTTANAAANNCCNNNNANNCCNNNNNGTG GGNGNCCNNTTNCCAANTCANNNCCNAANGGGGATGNNNTTNNCCCNNNNNNNGNNNNT TTTNNNNANGNGNNNNNNNNNNNNGNNNNNNNGNN^

NNNGGGGNNNNCCNNNNNNNTNINN^ NNNNNNNNNNNNNNNNKNNNNNNNN^ NNNNTSI^MNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNT^^

NCAANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGTCATGCAGGCCCTGCTGGGCCCGCAGTCCCTGCCTCGGAC CAAGGAGGAGAAGCACAAGCCAGCCCCCCAGGAGGACTCGGTAGCTGCCAGCAAGCAAG

CTTCCCCAGCCCCCAACATCAGCAGCGGCTCCCAGACCCCCCGGCGGAAAAAGTCGCCGT GATCTGTCAGCCACATGTCCTTAGAGGGTCAGGGTCGCGCTTGCCTCTGGCTCTCTGCCAC AGGAGGGCCCAGCCGCCGTGCCTTAGCCAGCTGCCATGCAGACGCAGGTCAGGGTGCTGG CCTGTGGGGGGCGCCAGCCCTTCTGCTTCAAGGGCATCCCCCCACCCCCACCACGTCCGGT CCCAGGACACCCTCTGACCTGCTCGACGGCCCAGGAGGCCCATGTGTGACCTGGCAATCG

GGGACCCTTGCTCTCTGCCCCCACGGCAGGGGTCCGAGTCTGAGCCCCAACCCCGGCTCCT GCACACGGGGTGGAGGTAGGGTGGGATGAGGCTGACCTGCTGGGGAAAAGGAGGGAAGA CGCCCCAAGGTCTCCTCTACAGCAGCCTGTCTGCGGTCCGGATCCGTGAACCAATAAAGG CAATTGTGTCTGACCAAAAAAAAAAAAAAAAAAAAAAAANTTGGGGGGGGGGGCCGGGN CCCAATTNCCCCTTTANNNGGGNGNNNNISINNNNANNNTSINNNN^ NNNNNNNNNTSINNNNNNNrø NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGG CAGGGAAAAGGTNGAAGATCTCCAGCCCGAATTCATAGAGATTGGTAATCAACCANAGGT TCACGAGCAGACATTTGACTGCTTACCTATCCAGACATTCTCTGGTCTCCCTAAATCTGAA CCCACACCATGGATGATTTTGAACGTCGCANAGAACTCAGAAGGCAAAAGCGAGAAGAG

ATGCGTCTGGAAGCAGAAAGAATCGCCTACCANCGGAATGACGATGACGAGGAAGAGGC CGCCCGGGAACGGCGCCGCCGCGCCCGACAGGAAAGGCTGCGGCAGAAGCAANAGGAAG AAGCCTTGGGGCAGGTGACCGACCAGGTGGAGGTCAACACCCANAACAGTGTGCCTGAC GAGGAGGTCAAGACAACCACGACCAACACTCAGGCGGAGGGCGATGATGAAGCTTGCTC TNCTGGANCNACTGGCTCGGCGGGAGGAAAGACGCCAAAAGCGCCTCCAGGAACCCTGG ACGACAGAAGGAGTTTGACCCACAATAACAGATGCCAGTTTGTCNCTCTNCACANAAGAA TGCCAAACCACNCCACAGACAATGAAACNGCGGAAAAGGAAGGAANAANTGAAAGTCCC NGGAAAAGGCAGGACCTGGAAGNAAACCGANATACTCCCCCNGTCNCCCCACAAAAATG GATTGGGATGGAACCCGGNANAAAAAANNNNNNNNCCGNNNOT NNNNNNTSπ^CTTGGGGGGGGGGGGCCf- ACCCO NNNNNNNNNANNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNN^^ c

NNCCCCCGGCNCNTAGTCNTTNTCACTCNNNNNNACCNCNNTTNNAGCCCCTATAGTGGA GGTTCGTATTNCNTGGGCAGGNCGCTCTAGAACTAGTGGNTCCCCCGGGCTGCAGGCNTT TCTCNNCCCANGNTTTTTTNTTTTTTTCCTNCTNTGCTCTCCNNGNCNNTTACCTCNG

CCTNCCCGCTOS[CNCNTTCTTTGTTCCACACTTTNTNGCTACG(^TCNGN(^GNTCNNTSπ^C TCGOSINGCCTGCC<^CTCCCCGTTNNCCTTGNTTNTNATACTNNTTNTANTTGTTCNC(^ NCGCCGNCTTCCTCGCTCTTCTNTACTTTCNTTNACGACC3SINCCCTCCNGNTCTNANTCGT NCTTNNGCNNNGNNNGCNCTCTNGNNTTTTCTNCTNCNTTCNCGTGTNGTNCCCNATCCNT CCTGGGCTCTTNNTCTNGCCGNCTCCGCAGNNNACCNNTNNANNCTNCNNTTTNCCCGGG

CC(^CCCNNCNGTCTCTCTTσSlNAANNTTCNGCGGGNCTCGNNTNGNGGTCGATNNGCCT CNNNNTCTNCGNTGTCNGCTCTCNNCGTTNTGNGNCCTNCCNTNNGCCGCCCNTGCNNCCT NCCNNTGCCACCNC^TSrGACNNNCrø^ NNCCCTATCTNCGGGNNNTTNNATTNTNNCTNGCNCTCNNNNGNNNGCTC TGGNTCNCGNCGTNTTCCCCGNATTTTGNCNGNNTNTNCCCCNCTNTANGGNTNNTCGGG

CCTNCCACTNATTTTCTNNTCNNNTNGTNNCATNNCNTNTCCCCCCCTACN^ NGCCCNTCCCTCCGGGTNCCTCTTNNAAANNCTNCTACNTTNCNCCTCTCTTNCCTCCTTCC NNCTCCCCCTCTAC^TCTCCCGANTTAGTTTATNCCCTCNT(^GACTNTTCTGCTCNNNNN CTTGNNCATNCTTTGNTTNTTCTGACTGACANGCCCGNAGCTTTGTTTCATTTNNGCCTNTA TNATTCNNCTCGTGNNNTCANCCGNCCTNTCTCATCTGCTNNTNCGCCTANCTCGTGNCTA

TNCNTCCCACTCNANCCCCTACTCTTCCNCTNCGTTATCCCCGNCNTAGTCCCGNACTTATT GNCTTCNTTTCCTNTCNCCTNNTTCANCGTTNCNNATCNCTTNCTTCT^ TCTNCTACTGTCT(^TNCCTCAGNTCCTNTNCATTCNTCGNNGTNTCCTCTTCNCCTTTGNN TACATCCTTNTGCNCCTNCCGNGCNCATNGCCTCNTTCTNTANTNNTCCTGCTGACTATAN CCCNCCCCG

GCCTATANNGAGNNGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG NAGGAANTTCGGCACGAGGGTCAGAGCCAGGTCCATTTTTTAAAAGGNAGCTGGCNGCTG TAATNACAAANCNTTTTNANGGAAANGGNACCTAAAANTNNCTTNNNCCTTGNTNGTGNN

TTTTNTTNAAAA(^TTNACCNTTNAAGGGGNAA

CNGTTGGGNNNATAACNNNACATAANTGAACCCTNGNGCNCNNGANCCAATGNAACNGG GNGCCANCCNCCTNANGACACCGGAAGAAGCNTNAACTNGAGACACCCGGAGAGAACCC TTACCTGCGCAGGGACNTATAGATNTGTNTGCACAGANATTTATANAAGAGANCTNAGAG GGGGANATAANTAAAANGCGTGGCTCNCATGCNGNGCTNTAAGATNGGGACTCNCNATC

TGATNCCNCAGGGAGCTCTATATNGCNNCCACTNTNCACGTGTGNTNNNCAANCCTCTAT ATGTNCC(^TANCσSICGCGCCTCNTNATCAATNCACACAATGGCATTTTTGTGGGGGCAA ATTGTTNTTTANAAATAANNTCTCCACACCCCACCCCCATATATTAGGTGGAATAATAATC TCNAGGTGGTGCCCCTTTTTCCCCTNGTNGCCCCCCANANAAGGAGGAAGATANNATAAT TGGGNCTNGGAATNANCCATCCCCCTGAACNTCCTGGTTTTTCCNCNAAANAACTACCCA

CTTGGNGGAANGTTGGCAAGCCTTCCCCTTNNNTTNCTTGCTGGTNNAACCCTGGCCGTTG CCαSINCCAACCTTATTCTTCCTCCCCCCCAAAGAAACTTGANTTGANCCTTTGTTTGNGNG GGCOSfGGGGGNCNGNAATAAAAAACCCAACC⁽^TTTCTTNTTTTTCCACCCNNCCCCCTTN AANGGGAAAAAGGNGCNTCCNTCC

GCCTATANNGAGNNGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG NAGGAANTTCGGCACGAGGGTCAGAGCCAGGTCCATTTTTTAAAAGGNAGCTGGCNGCTG

TAATNACAAANCNTTTTNANGGAAANGGNACCTAAAANTNNCTTNNNCCTTGNTNGTGNN TTTTNTTNAAAACNTTNACα NAAGG

TGATNCCNCAGGGAGCTCTATATNGCNNCCACTNTNCACGTGTGNTNNNCAANCCTCTAT ATGTNCC(^TANC(^CGCGCCT(^TNATCAATNCACACAATGGCATTTTTGTGGGGGCAA ATTGTTNTTTANAAATAANNTCTCCACACCCCACCCCCATATATTAGGTGGAATAATAATC TCNAGGTGGTGCCCCTTTTTCCCCTNGTNGCCCCCCANANAAGGAGGAAGATANNATAAT TGGGNCTNGGAATNANCCATCCCCCTGAA(^TCCTGGTTTTTCCNCNAAANAACTACCCA

CTTGGNGGAANGTTGGCAAGCCTTCCCCTTNNNTTNCTTGCTGGTNNAACCCTGGCCGTTG CCCNNCCAACCTTATTCTTCCTCCCCCCCAAAGAAACTTGANTTGANCCTTTGTTTGNGNG GGCCNGGGGGNCNGNAATAAAAAACCCAACCC^TTTCTTNTTTTTCCACCCNNCCCCCTTN AANGGGAAAAAGGNGCNTCCNTCC

TTNANAACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATNNNNCACNANGANNTGGNCCTGANNCCANCNCGCCANNGGNNNTTANG GGGTNGGCCCCAAACTNGGNGTGNCAANATTTTCTTAATCTGANCTTCAAANNCCTACTG GGTGGAAGCCCTAANGCCGATATGACAAGGTGCCTTCCCCTATCTGGAACTTGGACTNTA

ACCTNCATACCG(^TTTGTNTNTNCNCGGACCCTGNTGGNNGACANCTCNACTGACACGN TGGGACNCTGATGGTGATNGCCTGACTCCCAAATCNCCTNCCCTTCNCTTATGNAAAGTGG TGGNAACAAAAAANCAANTTGCCNGGNNGGGGNGAGGAAACCACAANGNCCTGAACNA AGGAANGGTTCCTTGNCAAGGGNTGGCHNAAGGCCGNTTTTGNACNTTCTANTAGNNNTN ACTTTfWTTANTTCACCNGGTCACTTANTGGA

CC^TNCGGANTTCATTCATTTCANGNACNGTTTAATTTGGNTAANCNTATANGCATGGGG AGGOSfNGAAATAGGGGACNCTNGGGTTNANANAAAAAGAANAAAACCCAACCCCCCCTG CCCCCCCCTTTTTTNTGAATOS[AAATTNTTCAAGGGGGAATGGNGGGNGAAAAAACNTπ TANTNGNGCCCGGαNNACTTTNAAATGGNNAAANGGGGGGAACCTTTAANACCCCCCCG GCCCCTGGGGGAAANCCCCTTTTAAATCTTTTCCC(^GTTGGGGATNCCANAGGCTTTTTT

GGGGCTNTTTGGGGGGGGAAAAAGAAAAAAAATTTNCCCGGGNCCCr cαSTNTTCCNTT TGCCCGTTTTTAAAAAANGGGGC(^TNGGGCCCTTTGTTAAAA TTTTNCCCCCTAAANCCCATTTGNGNCCCACCCCCTTGNGN

TTNANCACAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNTCTNAACCAACCATAAAGGATTGGAACCCTTNATCTACTATTNGGNGCTTG GGCCGGTATAGNANGAACAGNTCTNNGCCTTCTAANTCGCGCTGAANNAGGCCAACCCGG AACTGGTGCTCGNAGACGACCAAATCTACAACGTAGATGTGAACCGCACACGCATTTGCA ATAATCNTCTTCATAGTAATACCAATCATAATTGGAGGATTCGGGTAACTGACTTGTTCCC

CTAATAATTGGNGCTCCCGATNTAGCATTTCCNCGAATAAATAATATAAGCTTCTGACTCC TCCCTNCNTCATTCCTACTACTCNTCNCATCCTCTATAGNNGAAGCTGGGGCAGGAACAGG CTGAACCGTGTACCCTCCCTTAGCAGGCAACCTANCCCATGCAGGAGCTTANAGTAGANN TAACCATTTTCTCTTTACACTTAGCAGGAGTTTCCTCAATTNTANGAGCCATCAACTTCATN ACAACAATTATNAACATAAAGCCCCCCGNAATGTCACAATACCATACCCCTCTGGTCGTA

TGATCCGAATAATACCGGNGGGCTACTACTACTCTCGCTNCCTGNATTAAGAAGCCGGGA TCACAATGCTATTAACAGACCGGAACCTAAATACAACCTTTTTTGAACCCCGGGNGGAGG GNGGANANCCTTTTTNTATATCAACCCTTTATTCTGGATTNTTTGGGACNCCCCCCGAAAG NCTAAAATTTAAANCCTTACCCNGGGGTTNGGAAAAAATCTNNTCAAAATCGGGGANCCT ACTTCCTTCGGGNAAAAAAAANAANCCCTTTCNGGAATTTTTNGGGNAANAGGGTNGGGG

CTTTTAAAGGGCCAAACNGGAANTTNTAAGGGTTTCAATCGGGANGAANCCCCCCCCATT N TNNNNNANAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGCGAGNTTTTTTTTTTTTTTTTNAANANAN^

NGGGGGNGGGGGGGNNCNNATGCCCTGACNNANAAGNAANCTCAACNNGNNTNNACCG NATNTTTTNTTNGCTNCAAOSINCTNTCCAANATGTTNGAGNGNGGANGGCANAAACCNTG

_{ATTTTTACTTGNCTCCNACCAA}^

NCCTTTTCCMSrATNCANGNGGGGGNANANCCN^

TNNNC^CCTTNANGGNNACCCCNNATGNGGNNNAAANGGNAAANNGCAANAGGGGANC CCTTTNNTTTGGTANNTAANGGGGGGNNGGNCCNNANAAAANTTTCNGGTTTTNN^ TGGAAAATAAAGGGNTTNCCCCCAAAACCTTTAAAGGGGGTTTNATGGGAAAATTAAAAA

AAAAAAAAAACCCCCCNCCTNCNMSIGGAAAANAAATTAAAAGTTNGGGACCAAANAAGT

GGGGGGGGGGGTTTGTTTTT(^CCNAAAAAAGTTTTTCCCαSfCCCNCCCCCCGGGACCCN

GGNAAAAAACTGTTTAAACCNGGGGGGNAAATTCNTTTGGGGGGAAAAAAAATGNGGNT

TTTTAACCCNTTTNAAAAAANGGGGNGGGGCCCAAAAAAAAAAAAAANGGGGGNGGGGA

AACCNTTTCCCGGGGNCCCCTTGGGNG

TNNNNACANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGNNGGAGCANAGGGNCCCACCGGCGACTTCAGAGGGAACTCATTTACTGTTACCG TGCTCATCTCAGGAACAAAACCATTTCTTAGTGAGATAATATAGTATCAAAGCAACATGC AACCAAAACCTTTTGACATTTTAGGGCTAGTTGGTACTTTCCAGTAGACATGTTTGGTGGC TGGTGTCAAAΛGTCCGTAAAGCATI GCTGCCAAGTTAGTGGAATGCTTGCTTTTATTAAA

ATGACTGTAATCTTCCTTGTTACAGACAAGCTATCATTGGAAACCTCCTTTTACAGTACAG GGTGCTCAGAAACGTTTTGAGTACTTTGAAAGCACTATATTTATGTTGCTCCAAGGAGTTG ATTTTTCTCCAGGTTTAAAGAGAATCACAGCTTCGAAACTTTCATTAAAAATGAGAGACAG AAGCCACAGGGAAAATAAAGCAAATAGGATTTTCAATATAAATATCAGNGAGGAAAAAA TATCCCAGTCTGTTGGAGTTAGTGTTCACGCAGTCAAGAACGTCGNTTNCATTTGCTCANA

AAATCCTTTCATGGGAAGTTTGGAGAACCATGAATGTCGCAGACTTGGTCTGGTGGGGTT GCACTTTATTATGGGGGGGGGGGGGGGNGGTTGGGGGGNTTAAAATAAAACCAAGTCAT GNGCTTTTATTTCTACCTTGTAATTTACCGGANGTTCCCCCAANCTTTTTAANGGNGGGNC TTNNNNCTGGAAAGGTTTTTTTGGNNAAANGGGAAGGGGAACCTTCAAAANGGCCGGAA

ACCNGGGGGGCCCCCAAAAAAANGGGGGNATTTTTGGNNCA

AGCCCNCATAGGNGGAGNCGCATNACAGGGGGGGCGGCCCGTTNTAGTAACTAGGTTGG ATCCCCCGGGCTGCCAGGNANATNTNαSfCGCANNAGGCNANTNNTCACCNCGTTTGNTCT

AGGAAGTCTNNCGNATGAATNATGGTGCTCNTCNGCCAGGTGCAGCNTTTCGANCAGTAG NNTCTACasnSTATGCCTTCATTTGCCNATNANGGTTCACTGTNTAATNGCATGCATGAGCCA CTNCGNANATATTGANTGTAGCCTNCGNNCTGNCTTGGGACCCGGGAGTANTATTTCNGT NNCCTAGNGCGCANGNACNCCTNTTNCNTTCGTCNNAACNCCTTGTNACANGTCACGNCT ATCANNAGACNCGNAGNTAAGNNANANNNGACNGTGCATNNNCTTGTTTCACTCNCTANC

NCTNTGANNTGNNTNGACNNTTNNAGNCTCTACACGNACTCCGNNATATNATNTCNTNTA GNGGGCAACNNCCNTANTGANCANGGTCTCNCAATGGATGCGNACGNNCCCTNCNTCCN NTTAACTNTTTNCATNTAAACCNTNTGGTGCCTTAANTANTNTNACTTNCATANCCACTCG CNANGTGCGGNTGNTNACNTTNGGTNGTCACATTNNGAOSπSINAANNGTTCNCNGNANTN GCGACATNCTNNGACCCANNTGTAAANNATCNNNNTAGATCTCGGTCATNCNTCTTCANA

TNNANCNNGCGTGNATNGAGCNNNANNACGACATCCATTAATNTNCNTNGAANNNCGGG TTCNGNNAC(_^TANNATTTGNTNTCAACGNNTNACTCAANNNC(-^ANNGTGAATT^ TATCCCCCNTNNGNCGNCGCNGCGNCCCNCNANNTANTCNNTNTGTCTNATGCCNCAAAN TNGNNN AAANasnNTTNTACT ^^ AATANTCTACTTANANTTNOS1NCNTS1NGTGTCGGNNATCAANNAANTGTCNGCATNGNTTN

NNGTGNNTNNAACTNGAGNNCAAGACATCCTCTTCTNGCCGCNANCNTGCATCNGTGNGA TNCANGCACTNNCNGTGNNNCTNCNNGTTCTNTANCATNNTCCTTCNATNNNMW CNTCANACCAAATNTANCGCTTCTCANTNTTNNATCCTGTACNNTNGANNCCNCGNNTNA GNTTNTTCTCNTANANTTACGNTNTGTTNTGTTGGCGCANCNCTNCGAGTCNTATNATANG NTANNNNANAGANACANTTACNTCTTACNANAGTNTGNGNCGNCNGNNGCCTAACTTCTT αSlCAαsrCACGTNCANNATTTNTCNCGCNATCGTNGTGANGACATGNNATGAGGNNTATTN

ANN(^CNTNAGACNN<^AGNTCATCTA<^ NCCCC

NCAAANCTGGACTCCCCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTTGC

AGGAATTTCGGCNCGAGGCGGAGGCCGNACGATGCCTGGNGTTACTGNAAAAGATGTCA

ACCANCAGGANTTCNTCNNAGCTCTGGCAGCCTTCCTCAAAAAGTCCGGNAAGCTNANAG TCCCTGAATGGNTGGACACCGTCANGCTGGCCAAGCATAAAGAACTTGCTCCCTACGATG

AGAACTGGTTNTACACACGAGCTGTTTCCANGGTCGGCACCTGTACCTCCGGGGTGGCGC TGGGGTTGGCTCCATGACCAAGATCTATGGGGGGCGCCAAAGGAACGGTGTCATGCCCAG CCACTTCAGACAGAGGCTCCAAGAGCCGTGGCCCGGCGGGTCCTCCAAGCCCTGGAGGGG CTGAAAATGGTGGAAAAGGACCAAGATGGGGGCCGCANACTGACGCCTGAGGGACAGAN ANATCTGGACAGAATTTGTGGACANGTGGCAGCTGCCAACAATGAAGCNTTAGACAAAAT

GATGCTGGGTTAATAAATTGCCTCGTTCGTAAAAAAAAAAAAAAAAAAAATTTNGGGGNG GGCCCGNCCCCAATTCCCCCTATNGGGAGNNNTSTNNTANN^ NNTSINNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNTSDSπSINNNNNNNN^ NNNNN fNNNNNNNNNrø

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNN^

GCCCTATAGNGAGTCGTATTACAGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCTGGTTACANCATNNAGTACNANAAGCCTGGGTCCCCTNCTAAAGANGTGGGNC CTNGGCCNCNNCCTGGTGTCACATAAGCTACTATNACTGGGCCGGAACCNNGANCANATT ACNCANTCCAAGACATTGNCCTTGANANCANTNAGANAAATGNGNCTTTGATNGGGANG AANANGACNGATGAACNNCNNNAGGTGGTAACCCTTGCACACCCCAATCTTCATGGACCA

GCAGATCTTGGATGTNNCCTCCNCAGGA(^AANGACC(^TTTCATCANCNACCCTGNNNN TGACNCNGGAAACAGNATTNANNTTTCCNTTNCTTGTGGACNGCMNNCCNNNCTTGGTCN ANAAATGATCTTTGNNGANCATGGATTTAGNCCANCCACNNCGACCACCANGGCCNCCCC AGTNAGGNNTAGGCGAAAACCGTNTCCGCCGAANGNAANNGATGANATCCAAATTGNCC ATNTCCCCAGNGGAGAC^TAGNCCNTCTTCTTTACCCTCACGTTGTGNGACTCNCTTCCTA

NTGCTTTCTACAGGGACAAGNAGNATTTCTCTCACACAACCNNTCTNATGNACCCCCATTC CACGAANAGCCTCTGAGCNTATCATTGTCATGTTCATCCCNANTTAGGCTACTGATGAAAT AACCCCTTTNCTGGTTTCCNAAATTCCCTTGGAACNCCNCNNGCTATGTGGCTANNCTNTN NACGGNGGNCTAAC(^AGNAGGGGGCCCANCCCTNCCTANNTTTNNTTANGANGGANGG CNATGTATTANTNACCCACCTTCATTGGCTTGANTGGTTTNNCCGAAGNAAGTTGGGTTTT

NCCCGCCNGGNCNANNTCTTGNTAGACCCNGNGGGNCTANGNTTNNNTCCCNCACTGANA GAACATNCNNGTNTTTGACCCCCCTACCCCCNNTC ⁽

GCCTATANNGAGNNGNATTACAGGNGGCGGCCCGCTCTAGAACTAGGTGGATCCCCCGGG

CTGCAGGAANTTCGGCACGAGGCTGACACTTTGTATTTCCTCTGGCGAAGAGAACTNGGC ATCTTCCTNAAAACCCTGCCCNNTCGGAAANTNNAAAACAAANCAANNCNCCNNTTTTT^ ACCCTTNANTTNCNANTTTTAAANTNAAANN^ C TNGCTNNNGGNTTTTAAGGNCCNTTANNCCTTTTTT^ AGAACTGGATGN<_K GACCTTGGTCCCANGTTAACNTCANNTCTGGNGTCATTANTTGCC

CTGCCAGTGGTCTTATAAAATTAGCAGGCNCACAATCTGGGAGGANATATATTTAAGNGC ANGGGGANANGCTCAATCATTGCGTGCGCTTTANNNGTATGANANANNNATCTTATCACC TNTAGGGANNAGAAAAGAGATGAGNGCGNTAATTTCANAAAACCTGAGTANGGAGGANA TGCGCCAGACAACANCNTCGCTGNATTTCNCTCCCTNGTGGGNAGAGGNGNTACCCCTCT OSINCCAGAACCCCAGAAGAACCTCCACTTTTGNAGAAGCTCTTTTNTNCaWAAGANCCT

GGCTGAANAANACTGCCCAAAACCATACTTCNAGAATGAGGANTCTCAGTGGGGGGGCN AAGNACTGNTGGGGGGCNCCATCCTCACAAGGNGGGTCNGGGAAGNTAATGGGGGNCCC TCaSfTTTITi TTGGATGACCNCC^ CCaWCCCCAGCGGGGGGGAAANAAANACNCCGNTTNGTTCCTTGGAANGNCTNNGANN NAAAAACANTTGNCCCCNCGGGAAAGGANTNGAANGGGTTGGGAAAACCTGGCCTTTCC NTTTCCCC

GCCTATANNGAGNNGNATTACAGGNGGCGGCCCGCTCTAGAACTAGGTGGATCCCCCGGG

CTGCAGGAANTTCGGCACGAGGCTGACACTTTGTATTTCCTCTGGCGAAGAGAACTNGGC

ACCCTTNANTTNCNANTTTTAAANTNAAANNN^ CNNGCTNNNGGNTTTTAAGGNCCNTTANNCCTTTTTT^ AGAACTGGATGNCNNGACCTTGGTCCCANGTTAACNTCANNTCTGGNGTCATTANTTGCC

CTGCCAGTGGTCTTATAAAATTAGCAGGCNCACAATCTGGGAGGANATATATTTAAGNGC ANGGGGANANGCTCAATCATTGCGTGCGCTTTANNNGTATGANANANNNATCTTATCACC TNTAGGGANNAGAAAAGAGATGAGNGCGNTAATTTCANAAAACCTGAGTANGGAGGANA TGCGCCAGACAACANCNTCGCTGNATTTCNCTCCCTNGTGGGNAGAGGNGNTACCCCTCT CNNCCAGAACCCCAGAAGAACCTCCACTTTTGNAGAAGCTCTTTTNTNCCNNAAGANCCT

GGCTGAANAANACTGCCCAAAACCATACTTCNAGAATGAGGANTCTCAGTGGGGGGGCN AAGNACTGNTGGGGGGCNCCATCCTCACAAGGNGGGTCNGGGAAGNTAATGGGGGNCCC TCCNTTTTTTNATTGGATGACCNCCTTAAACCNCNTTTGGNAGGNANTTGGGAGGGGAAC CCαWCCCCAGCGGGGGGGAAANAAANACNCCGNTTNGTTCCTTGGAANGNCTNNGANN NAAAAACANTTGNCCCCNCGGGAAAGGANTNGAANGGGTTGGGAAAACCTGGCCTTTCC

NTTTCCCC

TTGAANACANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCTANGTTGCNTNANCATGGCTAAACGCACCAAGANNGNNNGAATCNTGGGC

NANTACGGGACCCGTNATGGTGCCTCNCTCATGAANATGGTNAAGANNATNGAAATCATC CAGCACGCCAAGTATACCTGCTCCTTCTGTGGCNAAACCAAGATGAAAAGAATAGCTGTG GNCATTTGGCNCTGNGNTTCCTGCATGAAAACAGTANCTGNTGGTGCCTGGACCTACANC ACCACCTCTGCCGTCACAGNCAAGNCCNNCATCANANGACTGAAGGAACTGAAGGACCA GNAGAGGC^CCACCATTCGATACCCTTGCTAGCCTATNAAATGGGTTAATTTATCTANCNG

AANATCCTTTTTTCCACCTCGGGATGCCCG ^TNNTGTNAAAAGGGGTTCNCNNGGNACC CTTTTCTTTAAANNTTAAAACCGOSπsrCGACCANCCTTNGGGTAAAAANCANAGGAAAAAA C(^TNCAAACCGGNNTNTTGGACC^TAGACNANATCGNGCTTTTGGATTNNTGGGGAACA NTTTCCGTGNGCCATTTTGACATTCAAATNTNGGTTTTTTGTTTGCAAANGCC NCCCCTGGGCCTTGGGTNGGGGNAAAANGGCCCCCC(^TTTGG(^AAAAANTTTCCTTGG

CTTAACCTTTNAAAANGNTTNTTTTTTTTTANCTNCAACCAAAAGN^ NCCCCCTCNAANCTNGGGGNNTTTGNTTTGGNNGNGTTTCCNANTNCNGNNNGAAAAAAA CNCNNTTTANGGGGTTTTGNGGNGNTTNTTGGATTGTTTTCTTGGGNNCCA^ TTNNAΛCCCAAC NNAAANGGGCCCCGGGGTGNNGCCCTTTTTTGGGNAATNAATATTAA NGGGTNT

NAAAAGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGGTTTTGTTCCTTATTTTACTAATGATAATTAACATCCAACATGGCTTCTCATGCTAT TTCTACCTCACTTTGGTTTTGGGGTGTTCCTAATAATTGTGCACACCTGATTTCACAGCTTC

ACCACCTGTCCATTGTGTGAACATTTTCCTCCATT^

AAAACCCAAAGCTCTAAGGTAACAAATGACATGAAGATTTGATTTTAGTCTTGGCTTTTTT

TTTTTTTTTNCCNTTAAGGGNNCNNGGAN^

TTTTTTTTTTTTTTAANCCNGNNNTAAAAA TNAANTTTTTTTTTAAAANCNNGGGGAAA

GGTNAANTTAANNTTTAAAANNNTNNNTNGGGGGGGGGCCCAAAAANTTTTNAAAA

NCGGNANGCTTTNTNGNCNNNTTTNANNC^^

NCCCCCCNAGGNNNAAANGGGAAGCNNNAAGGGANCNNGAANCAAAACCCCCCCCGGG

GGNGTTTTNNNTTTGTTTTAAGGGGNCNGGGNTTTTAAATGGGGAACOW GGGTTAAACCCCCCCACCCNGGGACC(^TCCCCCAAANNTTTTTTTTAAAAANNTN^

NNCCGGNGTTTCCCCAAAANATTNAAANNTTTCCCCAAAAAAANNNCCCCCCNAANTGGG

GNNAANAAANCCGGGGNTM?GGGGGG JNNCCNAAAAAAANNCCCCCCCCTTTTTNTTNA

AAAAAAAAAAAAAAAAAAAAANNNGGGGGGGGGGGGGGCCCCGCCCCCTTNN TTNNANCNCNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAATTCGGCACGAGGACGGNTTGCANCCAACATTTACAACAAACAGAGTTT CACCCAGAGTTTGAAGAGGAGAATATCACTGAAGAATATATTTTATTCCTGTGGTGTAACC TATGAAATAGTATCCAACATACCAAAGGCAACAGAGGAGATTGAGGACCGGGAGACGCT

GGCTCTCATGGCTGCAAGGAGTTGAGAATGAAGGCACATCGGATGGGGAGACGTACATCG AGAAGTACACGCGGGGCGTGCTGCAGGTGGAGAACATTCTGAGCCTGGAACGACTCCGGC AGGCGCTGACGGCNAAAGNAGCACTTTCCACCAAAGCTCGGCACCTACCGCGAAGCCTCA GCACGCCCAACGTTCACAATGTCTNTTCCAGTCGACCAGACCTTTCTGGNTTTGACGATGA TGATAAGGGTTGGCCAGAGAACCAGTTAGACATGTNTGATTACAGCCCGAGTTACCAGGA

TGTATCGNGTTATGGAACTTTGCCTAGGGATTCACCTCGAAGGAGTAAAGAAGGTATGGT TGTACATTANAAAATNCT(^TGCCTTAANAGTCAGCCCTTTTAAAAGCATTTTTπ

AGGGNNTAGNGGCTTGGAAACCANNGGCCCTTTTTTTAANCCCNGGNNGGGNCTNTTGGG GGGNGGGGGGGAAAATTGTTTTTNAAAGGGTCTTAAACCGGGAAAGCTTNTATANTTTTN

CCCNCCCCTTTNTGTTCCCTTGGGGGGAGGTTTCCGCTTGACTTTNAAANNGNTTTNCCA^ ATGGCCCGGTTTGGGAAAAAAACAAAAAAAANNGNGrTTTTTTTTTπ

NCGNGCNCOSrøTGNCTCNTTNlW^

NTNNANCCTCTANCCCTA(_^CCACNNNCNAN(^CNCAAGGGGNNGTN(^ATATTNNATTT GCNTATNTTTAAGCCNANCNGGAGTTCGCATNACAGNGGCGNNCCGCTCTAAAACTNGTG NTATCCCCCGGGCTCGNAGGAATTGGGCCCCAGG(^ATNNTNTTATTTCTGCNTTTTGTTT NANCTGTNCCGGGNCNTCNNNNNGTNATCΑSΠSICTTNNCATAACTNANNTTNTNCAGNACC ACTCCTNGNNNGTNNNNNATAAN^INNNGTTCTAATNCTTNTCTCCCGGNCTNTTΠ

CTCACTTCATTAAANNTNAATACNTTN^ NMWAGCANNNTTNTNNNCNNACCTN^ TTCTTAAGCAGNNNGT^TANTNNTNTO^ NTTGNAACTACCTCCCTCTNANAANTTNNCNANTNCATNTTTCTCNCNTNNTCTATTT^ NTTTCTATTNNNGNTNTCCC⁽^CNCTTCCTCTTNATTNANNTTTTNCNCCCCC

CNNCTTCTTCTNGTNCCAGNNGGTCCCNNNC^ NTGTNNNTCNTNTNNTNGCTRØTCNNAC^^ (.MWCA^CANCCNCTNTTTN^TCG^ CTATNATTNTCTNNTNACTGNTAAGNCNGCCGGTNTCANNGNTNGANTCATTANNTNTTA NCANNATCACGNNCTAGCNANTTTTWANCNN^^

NCATGCGCTTCNTNCTNTTGCNCTATCTNTTNCNNNNGATCNCNACNNTCCATCTCNTTTA NTNGCTNATTNNCACTTANNTGTGANCATATCNTANTGACACNGTNGCGGTCTATNAGCTT CNTATN*WANC »J NNGT^ANNNCN^ CANNNCNCGTATNC(^CCTTCGTTCNCNNGNAGNGTGNTNNCNGATGCTGCNCACTGTTC TCNNNTACANNGNTC NNTNTCTTT^^

CGNTTNANNNCNCNTCATCNTACTNATNNANACGANAATNCNCTGACCNNNCANAGANA TGCCTNNACACCGANCCAGACANCGACTGTCNCACGTNTTGCNCNANNTTNTTGNNTACN AGTNANANACGCTGCATAG INATTNNTTNANTNTNCTNCGAGTTANANATCTANTGACAG NNATCGCTCGNATNNTNNATGNAANATTNATNTGNCGANAGNTTNNTNNNANGCTO ^'ATN ATCATNTGATNTTACGCC

NNNNACTGGAGCTCCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGCCGGCCTTCAAGTGGTGGCTGACAGGCCTGGTAGTGGGGAAGGGTGTCCTGGGTTGT TAGAGGGTCTCCAGGCTCTTCTGGTTGTCCTTCCCTCCCTTTTCCACCATGAGATCTATGCC

ACACAGGCCAGTGTCTGCAGAACCTTGCTTTCTAGGTTTGGTTTCTGANCTCCTGTCTGTA CTTTTGCCTCCTCCAAGGTTTTTTCCCCTAAAAATCCCCATTCTCATGCCTCCCCACTGTGG GTCTCCTTGCCTTTCTCTTGCAAGTTGGACAGTCCTCTGCCTNTTGGCCAGACCCCATCCAT TTGGACTGCCTAAGTCACTCGAGATCGACCCCCACCCACACGTACAACCCCAGTGGCCAG AGTAGGCAGGGAGAAAGTGAAGAGAATCCAGCTGCCTCTCGAGGGAAGTGAGATGTGTG

AGAGCACTGTANCTCCCCACCTGTGGACTCTGGGCCAAGAAAGGCGTGTGANTATCTGGC GCANGGTGCCAACATTCTTGCAAGCAGCTGCTGAAATCTGCATCTTCCCAGTTGGCTGGTA CTCCATANCCCTTGGACTTCTGCCCCCCTTCTTCTNCCTGTTGGTCTGCCCTTCTCANAACA GANCCTTTCCCTTCACTCCNTGGCCCCCNTGGGCTGACCAAAATGGTGNTTTTTTATGGGA NCCCCTTGGCCCAANAACCCTGGGGGGCAAGAAAANACTGGCATGAATGNAAAAACCGC

CNTCTNGCTTTCTTGGGAGGCAGGCTTTTGNGGGCAAAAGGAAAAAGGGTCCCGGCCTNG

CCCTTTGGGNAANGCAATTNTTNTTGTTGNGGAAGGGGGGCCCTTCGACCCCCCCCTTGNG

TTGTNGGGNCACCCCCCCCCCNNGGTTTNTTTTTTTAAAAAGAAACCCAGGGNTTNCC^

CCCCCTTCCCNGGGNANAAGGGGAANCTCG

GCCCTATNNGGAGCNGCATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATNCGNCACGAGGNNTGTCTTTANCGTNO^CNTNGAGGGGGNNNCCNGGTTCTC NGNACCCCCNANANNNACACCTNNTNGNAATCGGNNNTNTCCNACAAANCCTGNCTGNC

NNATNGNNANATNTNGNCNNAANATC(^ACNANACNANAGTTTCCCATTCNTTCCTTNNN GGAJSINNAAAGACANTNAAAANNGGAAGCAGGGNGGGNANNAGGGNNACNGNCCCNAAC CCTNGAAAANNGCCTTNNAACCGNGGAGNGAAATCCCNTACCNTATTNAACNGCCNGCC NNCTCTTGNCAAAAACCNAANNATATTNCCCTNGTTGGTCNGTNAACCCNCAATNAAANA CNGNATANANCCGGATACANATNTACCCATNTNGNNCCACCAANGCCAATGGGTGGCTNC

CTTTNTTACCAAAN(_ rGNTTTCNNTC

AANGGAANGTGGATNNGNTNCNATNAACTNANANGANNTTCGNAANGNNACCTATGNAN AANAAGANCCCCCANNTTTGNTCCTlSπsrCC^ GGNANACTNCNATTTCCCTCCGGNGANTAANTCNCTTACAAAAAANGCNANCAANNTATT TGNGCTACTTTTTAAAANACCAGATNNNTCAATTATTNAGCCCNTTCTTATNCCCTCTTNA

NTCCATANNNCNTTGGGGGCNCNGGNCTGATTTTTAAGGTCTTNTNNTAANNNAATTAAN TNTNISINACCNCTAAGGNAGCCCCNCCCOSfNCTO^ CCGCNGNGCGNNGNNCCTTTNGTCNCACTNNOW^ TNCTNTNNNTTATCNGTANGAGGTCNNNGGAGNTANNNGNACCANCCCTCCMNTTNN(-^G ANGNNTNNNCGNC

GCCTATANNGAGNNGNATTACAGGNGGCGGCCCGCTCTAGAACTAGGTGGATCCCCCGGG CTGCAGGAANTTCGGCACGAGGCTGACACTTTGTATTTCCTCTGGCGAAGAGAACTNGGC ATCTTCCTNAAAACCCTGCCOSπSfTCGGAAANTNNAAAACAAANCAANNCNCCNNTTTTT^

ACCCTTNANTTN<.^NTTTTAAANTNAAANN^ OSINGCTNNNGGNTTTTAAGGNC^^

AGAACTGGATGNCNNGACCTTGGTCCCANGTTAACNTCANNTCTGGNGTCATTANTTGCC CTGCCAGTGGTCTTATAAAATTAGCAGGCNCACAATCTGGGAGGANATATATTTAAGNGC ANGGGGANANGCTCAATCATTGCGTGCGCTTTANNNGTATGANANANNNATCTTATCACC

TNTAGGGANNAGAAAAGAGATGAGNGCGNTAATTTCANAAAACCTGAGTANGGAGGANA TGCGCCAGACAACANCNTCGCTGNATTTCNCTCCCTNGTGGGNAGAGGNGNTACCCCTCT CNNCCAGAACCCCAGAAGAACCTCCACTTTTGNAGAAGCTCTTTTNTNCCNNAAGANCCT GGCTGAANAANACTGCCCAAAACCATACTTCNAGAATGAGGANTCTCAGTGGGGGGGCN AAGNACTGNTGGGGGGCNCCATCCTCACAAGGNGGGTCNGGGAAGNTAATGGGGGNCCC

TCCNTTTTTTNATTGGATGACCNCCTTAAACCNCNTTTGGNAGGNANTTGGGAGGGGAAC CCαsrNCCCCAGCGGGGGGGAAANAAANAαsrCCGNTTNGTTCCTTGGAANGNCTNNGANN NAAAAACANTTGNCCCCNCGGGAAAGGANTNGAANGGGTTGGGAAAACCTGGCCTTTCC NTTTCCCC

TNANCAANANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGCCCGCGGATCTGTCTCTTGCTTCAACAGTGCTTGGACGGAACAGACCCAGGG ACGCCCNTTGCTCCANCCTCCGACCACCNTCNANCNTTTTTTCNAGCσSINANC3S[TTNGNAG NNAGC(^TTNANTNGN<_^GGAANNNCNGGANCNANC(^

ANOSlNNCNANNNNNNA(^TC(^AAATNNGNAAAANTANTNTNNCNN^ (^GαSTAC<^G⁽^GNGGTAACA πSfGNANTGGGGGGCCNTCTAACCTATACTTTTNTTTGGG TTNTATTTTCACACGCGNAA(^ATGGCCCTGTGAGAGGGTGNGGNACANTTTTTTCGANA ATNGNCCAAGAGAAAAGCGAGAGGGCGCNGAGCGTCTTNNNANNGTGNAANANNAGNG GGGGGGGCGC^CTCTTTNTGNNNNNGOSrCAANCCNTATCAAAAAGAGAGGGGNGAAAAN

CACGAGACTNTNNNGGCGCCCTTTTCNAGAAAAAAAACCNAGNANCACCCNGTGGANAT NTGGGNGCTGNGTCTTGNCCCGAGACACCCCACNTGTGACNTCTTTGGTGGAAAACCTCC TTCTATGANGAAGGGGAGNTCCTCATCAAGAAGGGGGGCNATCTTANNAACCTCCTCCGG ATGGTTGGTGCC<^CCATGGTGNGGNNGAGGAANTTTTTNTTAANNGNNGCTCCCCNTCN ANNACTAATAAGGTTCTTGNGAACAACCGGNCGGTCANTTGAAAAACCCCAACTAAANG

GGNGGCTGGAAAGACCCCCCTTTTNNGGAAATAAGGAAGGTTTTTTTTAAAAAACC

GGGGCNC(^TTTNNTCCNNGGNNGGNAJS1NGNAAAGNAAAAAANNTTT

TTGANAANNNCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAANNNNCCAJSTGAGGCTNNA(^CTNANANGAGCTTTNNGTGTNCTCNANGTN

NAACNCCGCNTANCTNTGTGATTNGCCTNNAC^^

CCNCCATCTANNCTNTCNANATCCNNATNATGNNATANATGANAACCCGGACAAAGCNCA ATTCGTGGGCCCCCTTACCCTAGCATGTCCAGAACGGNTTTANGGANTGGANTACGNTTTT

TTNNTTATAAACNGAANCCNATTCTTTACCGNTTTTTT^

TTGCCCCGGCCCATNAATTAGGGGANTNCTGNCNGGGGNGNGGCNTTANCCCATTAANCC

TTTTNGANGTNNAANNGNNAATCACNTCTGTONNATGGGTTTCCGAAGTπ

AGCCAATNTTANNACAANNNAGGGGAOSINCGAAGGNNNATGNTTACATGGCCTTATTNA TGGCCATWCCTTTGGTNATTGTTNTT^^

CACACTTTTNNNNATANCTCMXCGGGTTT^

GGGGNTTCCCTTNGCTCTAAAGGAAAANAANTGGGGGNCACCCCTTTTCTAAAATGNGNG

AGNTNTCTTTTCGCC(^<^TTAAAAAATTTTTTTTTCN

TCTTTTAAACCCNTNTGGCGGNGAAANGTNATTTTTGGAAAANGGGGNNTCACACTTTTCC CNTTTAGAANAATATTTGTTGNGGGGGGNNCHITT^

NCCOSINGGNTTNTNNGNANTTNGCCCCNNCCCATNNNCCCNNTTNNACTGGGGGGGGGG

GGGGGNTTNCCCCNTNATTTNNGNAAANNAAATATGGGGCCT

TTGANCACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGCTTTANATAGTATTTTAAAAGGTAACTAATGCTTTTGAC AGTATAAACAAAAAGCAAGAATATAAGGCCTAGAAAAATTGTCCTTCGAAAATATCAATG ATGTACCCTGGAATGTGAAGATGTCCCCTTATAGTTΓAAATTGATTTATTTGAATATTGTA ATCACTCTTCAGACTTTGAATGAGTCATTACAGTGTGTATCTGTATATCTGTAGAGAAAAA TGACAACCGAAATGTAACTTTAAAATCAATAAATTTGGCACTGTCTGTTGCACCACTACTG

TATCTTTTTGAAAGAATTAACAGTATTTTCTTATTGTAAAAGGTAATTCTGATGATTCCACA TTCACCAGACATGTATTTTTTTTTTCCTGTACTATTTGCATCCCCAAATAT^ AGGTTTTGCACGGCTTGANΣSRTTCAGAGATTAACAGAATGACANCTCANTTTTAATTCTAA AGCCATGAAATGTTGCTTTGANACTGAACAATCTGAATCTTATTTATAATGACNCCCAATA TCCATGTTTCCCTACTGGAAAANACCTGACAGTTCTTGCCTACACAGCAAGAACTTATTAA

ATCTTGGAAATNCCGGGCCTNTTTTAAATTCTGGGGANGCCGGGAAACAAAATATTTTGA GGGGAAATTGGTNTAANACAAAGGCNTTTGAAAAGGNTTTGCTGGCTTNAAACCTCCAAC AGGTACATTNTTCGGAAAGGCAACGATTCCCTGCGAAATAAATTTAATAAAGGTAAAAGC CCAACCCTTAAAAAAAAAAAAAAAAAAACCTTGGGGGGGGGGGCCCCGGNNCCCCAATT TCCCCCTTTAANGGGGGNNNC

AGNNR^NNNNNNGGNNN INTTNANAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAG AACTAGTGGATCCCCCGGGCTGCAGGAATTNGNTNCTNNNNTTNCTANTNCNTTNTATAA NNACGCACAACCTCTGGNNCATTNTCANGNNNAGNNTGTAANNCGTGNCTCNATAAAAN

GOSINANNGGANTAANANTANNG(^GCCTNNCTNCGTGAANGCTTNCCATANCTATTNTNC ATTACATTCCACATCANGATATCGAAACNATTCTACANNNTATNNACACTAGCATNACAT TATNTNTATTNGCTTTACTTNCTTATAOSΓNGGAAACTGNNGGTTTACTCTNTN ATTGTANGTCACTNTTANCTATCNNACTCTTGANNGGTNTNNAACNACTTNACCAGAACT ACCTATTGGGTAANGATNACATTACTGANCCCACTTANAACTTNAACCTGNAATGNTNTCT

TGCNCTAAAAGTGAACTGNCTAANTTANTGAAAANTACNNGTGNCCCCTACGCANTTGCA CNAATAAAAACCNTNNTTNTCTTNTNCCCAAAAANATGNNTTGNCTTAATTTCCCACATA^ ANGTTNATTTTCACCTCAAATANACTTNAAAATTTNTTTCTATANGTNNGGGNC^ TTNTAAACTTTNCCCGNCCCCNTTAAANAAA ^ CNAANAATCATTGGNGGGGGGCNCCCTGGNAACNCACTGGCGNTCTTNTTCCNAGCACTN

ANTTTNNTNGCCCGGAAACCCAAATTCCCNTTTTTCCCTNGGGANNCTTCTGNGTNAAAAN CCCCCNNGTTTTTTTTAAGAAANCTNTTGNCCTNGGCTTTAAAACC NNGGGTTTGGGGCGTGGACCAAGGAAATTTTNCCCCATTANCCCAACCCAAGGGTTTTNT GGGGGGAAGGTTCCCAAAAGCCAAANNNACNCNCGGGGGTGNGTGCCCCNNGAAACCCC CCCCCTNGGGTTTTNGGGGGNNNNNTTTTTCCNAAN

ANCAANACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCCTTGACGGGCCTCACCAGAGGGGCCACCTACAACATCATAG TGGAGGCAGTAAAAGACCAGCAGAGGCANAAGGTTCGCGAGGAGGTGGTTACCGNGGGC AATTCTGTTGACCAGGGCCTGAGTCAGCCCACANATGACTCCTGCTTCNACCCCTACACGG TCTNCCATTATGCCATTGGAGAGGAGNGGNANCGATTGTCTGANTCTGGCTTTAAACTCTC GNGCCAGNGCTTATGCTTTGGCAGAAGGTCATTTNACATGCAATTCATCTANATGGTGCCN

TGANAATGGAATGAACTNCCANATTGGATAGNAGNNNNATGGTAAGGNATAGAATGGCC AAATGATGAGCTGNCTTNTCTTGGAANTGGACTTTGAGAGTTNAAGTGTGATCCTCATGN GGCCGCNTGCTATCCGATGGGATGACTTACCACNNTGGNAGAACAGNGGNGGANGCGAC TGTCTTGGGGCCNTTTGCTTACTGCACATGCTTTGGAGGCCAACGAAGNTTGGCGCTTTGA CAACTGACNNANACCTGGNGCTTGAACCCGGTACCTAANGCTTCCANTGGCCACTCCTAC

AACCAGTTTTTCCAGANNTTCCATCCGAGAACAAAACCTTAATGTCAACTGGGCCAATTG AGTGCTTCATTGCCTTTTGGATGTNCAGGCTTGACα^TANAAAAATTCCCGAAAAGTAANT TTTTTCCAACCCCANAAAAAACAAGCGGTGGGATTTTCTTGNCCAAGNTCCCTTNCCAAAC TGGGAAGNGGNGNNTTCCCAANACCCCCCATNTTTAAGGGGNGTTCCTTTTNNTTAAAAC CCCTTTTTTNTTTTGGGAAANAAACTT

GCCTATNNGGAGCTNCANCNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGAGAGATGGGAGGGTGATCACACTGTCTCATGAGGGCCAGGA GCTTCAGGACTTCCTTCTGTCTCAGATGTCACAGCATCAGGTGCACGCAGTTCAGCAGCTA

GCCAAGGTTATGGGCTGGCAGGTCCTGAGCTTCAGTAATCACGTGGGACTGGGGCCTGTA GAGAGCATTGGCAATGCCTCTGCCATAACTGTGGCCTCCCCGAACGGTGACTATGCTATCT CAGTTCGTAATGGCCCTGAAAGTGGCAGCAAGATTATGGTTCAGTTTCCCCGTAACCAGTG TAAAGACCTTCCAAAAAGTGATGTTTTACAAGATAGCAAGTGGAATCATCTTCGTGGGCC ATTCAAAGAAGTTCAGTGGAATAAAATGGAAGGCCGAAACTTTGTTTATAAAATGGAGCT

GCTTATGTCTGCACTTAGTCCTTGTCTACTGTGATTTTTTTTTCTGGACCAGTTTCCAGATTT TTTTTCCCCAGAGAAGTTTCCAGAAACTTTCAGGAATGTTTGCAGATCAACAATAAGCACA AAGAAGAGGAATCTTCTAAAGGAATATTGTTTTTAAAAAGTAATAATTAGCAAATGTTTA TTTAGCATTTTGAAACCTTTCACTTTTATAAGTGACAAAGTGCTTTAAAATGCAAAAAAGT TTATGTACAGTTATAGGGTATACCAANCATGGAAGAGATGGTNCTTTTTTTATGCAGTTGG

ACTTGAAACATTACTACATTGGATGGCATTAGCTTTTTAAAAATATCCCNTTGATGTTGAN ATCCAAATAAAGATTTTGGTTAAAAAATC<^AACCCTNTGAACCCTTAAACCTAAATNNA TTATNGCNTAACCATTCCCNTTGTTGGTNATGGCTTNAAAAAAANTTAAAACCCCNTAAA AACCCAGCTTTTNACAAAAAATCT

NCCNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGTTTTTNANGAATGGCAGCTTTAATCATCCTGGCCAAGGCCCCTCAGGCTCCCTCCACT GCAGGCCTCCTTGGTCATAAACCCACCATCAACCATGCCTGAACACTTTTCCCAGGTGGCC CCTGCTCTTGGCCACTGACGTGGGAACCTGAGGTCATGTCAGTCTGTGGATCTCTCCTGGG

TGTGGATCCAGCAGCCCTGAGCCTGCTCTTGCCATCTCCAGCAGCTCCTGGGGGACATGGC CAGCATCAGCGGGAGGCTGGTTGGGGAAGACAAGTGTTCCCGCCACTGGAGCAGGCATTC CTCCTGGGCCGAGCTTCTTTGTGCTTTGAGACTGATGGAAGAGCGGAGGTGCTGGGGCAG AGGCCCAGCCCAGCCCCTTGAGGCAGGAGAATCACCGAGAAGGCGGTTTCCTCACAGCAC AGACAGGAGAACAGACACACGTGGGCACACACAGGCTCCACATCCTCTGCTGCTGCAGGG

GGCATGGCACAGCCCAGTGACCCTTCAAAGCTTCCAGGTAAGGATGCAAAGGAAGGCCTC AGGGAGTGGACCANGCCCTGGCCCTGGGCCCCAAACTTTCCCAAAAAGAAGAACCCCAA GCCTGCAGGGGCATNTTGAGAAGCTAGAAGGGGAGCCCCCTNCAANANAAGGCCATGGC TTGACAAAGGGACCGGAACCCAACCAAGGAGCCTNTGNGACTTAACCGCCCCGANCATTG CTTTTTGCCAACTTTTGNGGGCTTTNT^

NAAAAACGGGTTTTTAAATTAACCCCCCCCTTOS[GNTTTGGGANGGNTTTTGGGCNCGGNT TGCCCNTTCCCTTTGGGGGGCC(^CCGGGGNGGGGGGGCCCTTTTNGGNAANCNAAAATN NNTANTTNGNGGCCCCAAACANCACAAAAAAGNTT1TNGGAAAACCTTTTC GCCCTATCNGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGNANAAATTGNNANCAATGCATTCATNGNCCTTCCAGCCCCATCAAACATTGNCAT ACATGATGAANTTGCGGTTCCCTCCTGGGAATCTGCCTAGTCCTACAAATCCTCACAGGCC TATTCCTAGCAATACACTACACATCCNACACAACAACAGCATTCTCCTCTGTTACCCATAT

CTGCCGAGACGTGAACTACGGGGTGAATCATCCGATACATACACGCAAACGGAGCTTCAA TGTTGTTTATCTGCTTATATNTGCACGTNNGACGAGGCTTATATTACGGGTCTTACACTTTT CTAGAAACNTGANATANTGGAGTNATCCTTNTGCTCACAGTAATAGCCACAGCATTNATA GGATACGTCCTACCATGAGGACAAATATCATTCTGAGGAGCAACAGTNATCACCAACCTC TTATCAGCAATCCCATACATCGGCACAAATTTAGTCGAATGAATCTGANGCGGATTCTCAG

TAGACAAAGCAACCCTTACCCGAGTCTTCGCTTTCCATTTTATNCTTTNCATTTATNATCAT AGCAATTGCCATAGTCCACCTACTATTCCTCCACGANACANGCTCCAACAACCCNACANG GAATTTCCTCAGACGTAGACAAAAATCCCNTTCCACCCCCTACTATACCTTTAANGACATC TTAGGGGGCCCCTCTTACTAATTCTAGCTCTAATACTACCTAGNTNCTATTTCGCACCCCG ACCCTCCTNGGGANAACCCCATATAACTTNCACCCCCAAGCCCNNTCCGNNTTNCAACCA

CACCCCCCTTCANATTNAAANCCCGGNGGGGGGNNNNNCTTTTTTTGNCNTTACCGCNATT CCTTACGNATCCAATTCCCCCAACCAAACTTNGGGAAGGANGTTNCNC

GAGCCCATNNGGAGNNGCATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGATTTCGGNNCGANGGNNNTNCANGGGGTNTACCTCTGCCCCCAGGTNCTGNANC ATCNGCTCCTACACCAGTGGGCCCGGNTCCCGCATCAGCTCCTNGNCCNTTTCCCGAGTGG GCAGCAGNNGCNNCTNTCGGANGCGGNCTGGNCACCGGCATGAGCATGGCTGGAANCTA CNGTGGGGCCCCAGGNTTGGGGGGCATCACAGCTGTCACCGTGAACCANANCCTGCTGAG CCCCCTCAAGCTGGAGGTGGATCCCAACATCCAGGCCGTCCGCTCCCAGGAGAAGGAGCN

NATCAAGACCCTCAACAACAAATTTGCCTCCTTCATCGACAAGGTGCGGCACCTGGAGCA ACAGAACAAGGTTCTGGAGACCAAATTGAACCTCCTTGCAGOSINNNCNAAAGANTGNCN CGNNG(^AC^TAANACNCCATGTTTNATAGCTACATTNACAACCTCCGTCGGCAGCTGNA AAACTTTTGGCCCCACGATAANCCTGAAGCTGGAAGTGGAGCTTGGCAACATGCAGGGGC TTGGTGGGANTGACTTNCNAGACCANTGTTTCGNCGGNTGAAAAANTNANANGCCGCACA

NACNATGNAGGANTGACATTTCCNATCANTCAAGAANGANTGTGGGNCGAAAGNNTTAC NTTGAAACNNGGNNAGAANCTTGGATTNCCCNCCCTGGGAAAGGGNTTGGACTTGGATNG AANANOS[AANTTrCTTANNAGGCAANCCTGGTTTGNAATAAGGNT(^TTCNNTNGTNNNA GNNAGCTCNTCANTAATTTTNTGGAACCCNTNAGNGGGGTCTCTTGNCTCNTNGGNCAAA NNANNTCNGGNAANCTTGGANCCTCNTGANTGGCNNTCNNTTTCTTTGCTGGGCATNNGG

NCCCOsπ^TTTTGTNANGGNGNATNGNNNAATCCCNNAATTTCGGGTTNGA^ GGCNNNTC

GAGCCCATNNGGAGNNGCATNNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

NATCAAGACCCTCAACAACAAATTTGCCTCCTTCATCGACAAGGTGCGGCACCTGGAGCA ACAGAACAAGGTTCTGGAGACCAAATTGAACCTCCTTGCAGCNNNNCNAAAGANTGNCN CGNNGCNACNTAANACNCCATGTTTNATAGCTACATTNACAACCTCCGTCGGCAGCTGNA AAACTTTTGGCCCCACGATAANCCTGAAGCTGGAAGTGGAGCTTGGCAACATGCAGGGGC TTGGTGGGANTGACTTNCNAGACCANTGTTTCGNCGGNTGAAAAANTNANANGCCGCACA

NACNATGNAGGANTGACATTTCCNATCANTCAAGAANGANTGTGGGNCGAAAGNNTTAC NTTGAAΛCNNGGNNAGAANCTTGGATTNCCCNCCCTGGGAAAGGGNTTGGACTTGGATNG AANAN(^AANTTTCTTANNAGGCAANCCTGGTTTGNAATAAGGNTO^TTCNNTNGTNNNA GNNAGCTCNTCANTAATTTTNTGGAACCCNTNAGNGGGGTCTCTTGNCTCNTNGGNCAAA NTSrANNTCNGGNAANCTTGGANCCTCNTGANTGGOSINTCNNTTTCTTTGCTGGGCATNNGG

NCCCCNINTTTTGTNANGGNGNATNGNNNAATCCC^ GGCNNNTC TTGGAAACNGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATACCCGGGC TGCAGGAATNANNAACCANGNTNTGCCCAAGAANCAAAAGCGGAATTGTNCCATNGGTC ANTGGATTCTAATGAAAACTCGGCAATGAANTCANGTACAACTCCAAGAGAAGACACTTG GAGAAGAACCAAGCTGGGTNTATAANAAGCAAGCTGGNTCTATGAGAAGTGGTCTTAAC ATGTAGACCACTTTTTTAAGCAGCCAGATCACAATGAAAACATCACTACTGTAATGCTTGG

CCCATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCAATAAATATAANACGTTGCAC AAAAAAAAAAAAANTNCTGNGGGGGGGNNGGGGCCCσStNCTGTTCCNNTTTGGGNTTTT GANAAAAACATTNTTTCANTTNTGGGNCTTTTNTTTNTAATNNTNN^ NCCTCAATTGTANGGTANCNCCTTTCTCCNTCNNNNNNTACCGNTTNCNNTNTNN^ CNANTαsπSTCTCNNCGANTTN(^TTTTNCTTTTCAGANTTAANT^^

AGCOS[NNGANTTTTCTNNNTTT(-^TTTATTNT^ TCNTNNCNTGATAGNNGTTACAOSπSlNNTTTTTNTNGCNTNAANCTACCCCCCCT^

GTTTCTTNTTNNGTCGNNTCTTANNTTCTCTCTTTTTTACCNTANANNGTC TCTTTGCCTTANNTTCCTTTTCTCGTN^

TTCGTNTTGGGGNNTNTCNNCTGANACNNT^

CTNGTAGTNNTTATCTATTCNNAATAAATTCNTNAGGAGNTNANACCTACTCATTNTANCT

ANNATGTGTTTTNTNTTNACNTCTNCT

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGGAGAGGCTCCGCCTGTCCCCTAGTCCCACCTCGCAGCGCAGCCGAGGCCGGGCCTCC TCCCACTCGTCCCAGACACAGAGTGGGAGCAGCGTCACCAAAAAGCGCAAGCTGGAGTCC ACCGAGAGCCGGAGCAGCTTCTCCCAGCATGCTCGCACCAGCGGGCGCGTGGCCGTGGAG GAGGTGGACGAGGAAGGCAAGTTCGTGCGCCTGCGCAACAAGTCCAACGAGGACCAGTC

CATGGGCAACTGGCAGATCAAGCGCCAGAATGGAGATGACCCCCTGCTGACCTACCGCTT CCCACCAAAGTTCACTCTGAAGGCCGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGG GGCCACCCACAGCCCCCCTACTGACTTGGTGTGGAAGGCTCANAACACCTGGGGCTGCGG AAACAGCCTGCGTACAGCTCTCATCAACTCCACTGGGGAAGAGGTGGCCATGCGCAAGCT GGTGCGCTCAATGATCGTGGTCGAGGACGACAACGATGAGGATGGAGACGATCTGCTCCA

TCACCACCACGGNTCCCACGCAGGCAGCAGCTTGGGGGACCCCGNCGAGTACAACCTTGC GCTTCGCGCACCGTGCTGTGCGGGAATTTGCGGGCAAGCCCGCAAAACAAGGCGTNTGGC CAACTTCGGGANNCCCAGNGGGCGGATCCCNTCT(^TTTGGCTTCTTCCGCCTTCAGNGGG CACAGTCACTTCCAAGTTTTCCCAAAGTGTGGGGGGGCAAANGGGGGGGGGGAAATTTTN GGGGNANAAGCTTGGTAAACCCGNTTTNTAACTTTTTNGGGNAAATTCCNAAANCCCCNA CCCAAAAACCCCCCCAANNTNGGGTNGGGGTTNNTTTNGGGGGGGGNNTNAAAACAA ANAAAAN

TNNNNCAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCCTTGACGGGCCTCACCAGAGGGGCCACCTACAACAT CATAGTGGAGGCAGTAAAAGACCAGCAGAGGCAGAAGGTTCGCGAGGAGGTGGTTACCG TGGGCAATTCTGTTGACCAGGGCCTGAGTCAGCCCACAGATGACTCCTGCTTCGACCCCTA CACGGTCTCCCATTATGCCATTGGAGAGGAGTGGGAGCGATTGTCTGATTCTGGCTTTAAA CTCTCGTGCCAGTGCTTAGGCTTTGGCAGTGGTCATTTCAGATGCGATTCATCTAAATGGT

GCCATGACAATGGAGTGAACTACAAGATTGGAGAGAAGTGGGATCGTCAGGGAGAGAAT GGCCAGATGATGAGCTGCACGTGTCTTGGAAATGGAAAANGAGAATTCAAGTGTGATCCT CATGANGCCACATGCTATGACGATGGGAAGACTTACCACGTTGGGAAAACAGTGGCAGA AGGAATATCTTGGTGCCATTTGCTCCTGCACATGCTTTGGANGCCAGCGGGGCTGGCGCTT GTGACACTGNCGCAAACCTTGGGGCTGAACCCCGGTACCGAAGGCTTCACTTGNCCACTC

NTACAACCAGTNTTTCCCAGAGATNCCNTCAGAAAACCAACNCTTATGGTCACTGGCCCA ATTGAGNGCTTCATTGCCTTTGGATGTNCAGGCTGACCNAAAAAAATTTCCCGANAGTATT TTTTTCCAACCCCNAAAAAACAAGCGGNGGGNTTTTTTGGCCAAGGGNCCTTTCCAAACT GGGNNNGGGGTTTCCCNAANCCCCNAGGTTANGGGGGGTTCCNTTTTTTTAAANCCCNTTT GGNTTTGGGAANAN

NNTATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGNNNNNNGCNOSINNGGTCCTGGNNNNATGTGAGAANNNNGNCAANCNCTGNCNGGCT GNTGCCNTGGNC^TGNACNTGNNNAOSnSINTNAGGNGCNNCACACNCTGGCTNGNAC^^ CGCANATGNCCTTACNGNNNCTNGGACCNAAATGNNNGNCANGACCCGNNACTNNAACN GNNTACANGNTGNCATCNGGGNTNTGNNANNCCTGNCGGNTTACNNGNTGGCTNNNANN GNTCANGCTTNGCAAGGGNNTNAGATGACTNNTANAGATNCNANGNCNAAN(^GACCNN GNTNCTGGCCAGGATTNACNAACGCCCTCTGCTACATGGTNAGTGCTGTGNGAGAGNNCN

ATGAACTNANNTTTGTATTNNTGGCCCTNNNNGNTNNNANTNCCACNNAC TGATNNGNTATGAGAGCNNNOsINGNGTCT^

NCNα^CACGNNTACTTNCNTNGNNTGACNTCGNACTACGGGACNCNTGCTTCANNTACAG ACTGNNCCCTTGTTNACTGAATCNACCNAGATTGCGANCCTGNCNTNNTANNNANTATNC NTAN(^TGCNTGGNGAAGANANCGTNCTTATNACTNGCTGACCTNTTTCCCGNNNANAGT

NGCTTGCATTT(^CTGCNACCCTATCAAGAATGNTTTGGNTTACNAGNAAAACNNACCTC CGCCCCNrWTAAANATNTGGCGCGANCTNGA^ GCCCGNNA<^TGGGGGNNATTTATANTG<^TTGCTT^ CCNCNAAAAGCCAAAAGCAATTNNGNTTNTTGGAAACNTCCTTTGGGNGNGCTTGNNTCC CCCCNCCNTGGANTNGGNANGTTTTTTGGGNTNNGGTGGGC(^TNTTAAAANTTN

CCCCCCNCTCTCTNTNCCGCTNTNTTTTCTGNTTNTTNTNNNTTNNNNTC^ (^CNCNTNTTT(^CTNGCCCNGCGGCGCCCTCTNCNTCCNC(_^TGNGGCCTCNNNNNCAN ATGNNTOSπSINNNNNNTTTNAGCCCTTTCAGTGGAGTCGTATTNCNAGNGGAGNCCGCTCT

AANAACTAGTGGATCCCCNCGGGNCNTCNNGTCNTCTNGGNTNNGNTNTTTTTTCCTNCTC NCMNACCTCTNGTNTTTTTNNCCC<^GGGGGNN^

CNCCTNTTTCCGNGTTTTCTCCTNCNCCTGATTCTCGTCNCGNCCNTACTCCTGGTTTGNCN TTNTTCCCTGTNCNNTCTTCTNCTCTTNCNCGCGTNTCNCNGNCCCNNCTACCTCCGCCCNT NN INCNOSπSfTTNTTNCNCGNCCCNGTTCCTGNNCTCTNGNGTNCCTNCCCCCTC^^

NTTNCCCTNGTN<-MSTACNNCTNCCTNC^

CNNNCCTCCTCGNTCCCCNCNC(^CTTTCTCCCGCNCCNNTCNCTCCCGGCNTCCCTTCCTC CCTCCTTNCTCCCTTCCCCNCNTGNCNNCTNNN(^CCCTNTCNGNCCCCGANANTS[NNNTTN NCCTCNGGCCCCNCNCTCCCNCCNNTTANNTNTCCCCCTCCGTCCACGCGCCTCCTCTCNC GTCGNNCCNNTAGNCNNTTCCGNNCNGGCCGCCNCCNGTTNCTNCTCNTCCCNANTTCNT

CACTNGCGNTCCCGNNTNCNNGNCANTGNNCTNNNNTCNCCTCGNGTCCNCCTNNNTNNT NG<^CTTAGTCCCTCTATNTNNNTαs^

NCGNNGNNN(^CNATGTNCTCTNCGCCGNNTTGTCNAAT(^TNCNCNNNTCTNTCNCCGT CGTGGCNCNTGC-MNNCNCCCTNCAANTCTCCCACTTTTTCCCTTTCCNNCNTCCTT^ NNTNTTTCTCCGNNNTTNCCCGTT(^TCCC^CαSlNGGTCNCCCTCAGCCTCNCTNTTNCCC

NCCTTCCCNCGGNCCTCNNCGACTNCCTCCTGNCGCCNCTCCTNTGNTGNNNTCCNCTCNT CTAOSINCαSINCNCTNNCCCNCCTCNNNNTACTTCGTATGGNGCTαSINANCTCTTCN^ NCCCTNTTTCTACNTNCCT<^TCT^ NNGCTNTNTTCCGCCGTNTNTTNCATTGTANGNGG NCTCTCTCCGN<^TCNCCTCNTTOSfNGTCTCNNCTCTCTCTCTNCNC3SINTTNTNNNNCCTCC CCGCNCGTCGGTTCTCCNTNTNTTNTGGCACTCNNCGTCTGNTCGCCTCGCTNCNTNGNNT

NC CTCGTNCCGGTTTCCCCNCTTCTCTNTTCOWTNACTGTCNNCTCCCCACNNACCNNT GCNTNCTNCNTNCCCTCCNTNTCCCCCCNGCGTGNNCCTCCCNNCGNGTCTNTCNCTCATC T(-ΗNCTTGGGTCTGACGCNTNCGCTAAGGNNNCNCNCCNATNCCNTNGCTCNCTCCGCNC TCTTCCNTCCTTNCNGTNNCGTANNGCACCNACATNTTNGTGANCCCNTCGCTCTGGNCNC CNCCTCNCCGCTTNGTGCTCTACTCGNTCCGCCNCNCTNTNCTCCGTCTCTCCCNCGCGC

GCCCTATAGGGAGNCGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTTCGGTACGAGGATTNTTGTCANCCTGNCGACCNGGANGGGGGGTCNNGGG GANGCAATTTNGCCCATATNNTGATCTACNTCΠ^

GTCCCAGTGACACNGNGAGACNATNCACAGNGNTCNTNGNNNGCTNCGAATGACCNCTT GNNNGNNATCATGACCAGNCCGANGGNTGATTNTAGAATTGCCTGTGGGACCAGCTAACN NTΑ ^GCTGNGGCHNNGCNGTAAGTATNTGNNTGNANTGNCCCNAATCTANCTGNNGAN GGACTNAACTTTGNNTATTNNNNNCATCTGNNACNCGNANCANCAGCAGAGANGCNTCTG NGNNTNGAACGAOSΓNNCTCTGTGNATATANNNCAATTNNGGGGGNACANCTGCCANANC

ACCTNNNTTGNNTANTTGNGCATANCTGNAAAGGNANTNNNTTCNNCTCTNACCGTNGGG CTNTTNAAGNAACN⁽^TTGNTNCAGGNGTGCNTGNTCTNTNNGANACNNGANTGNNNTNN NCCNCNNNTCGNAN(3NNATNNNCANGNANGANANGNANGNGGCCAGTNANTNNNGNNT CTTANACCNANTCCCNNTGCACTACTTCLTAGΑSLNAACCTNCTGGNCTTNAANNNNTNCN NTTAAGAANTNTNATNTTTCTACTGTCAGN^ OSπsrGGGGCHNGAAANAATTANCTAAJSfTC(^TTANTGNTCCAαSfTNNAAGGTGCCTGNTCC

CCTNGNANCGAAAANGANCTT(^TNCACTTGGGNNNCGNNCNNTNAATTNNCAAAATNA NNTNCNNNNTNNTTTNTTCTGNGGTGGTTGTTGTTNTTNNA^

NGGNNAGGATNTCTCCTGNATNACTTCNTAGAGNAANTNATCTNNCNANCNANNNTTCNT CNAANAGGNCTATTANCNGTCCTNCGNTANANTNGNNAANNAGNCCAGNACCCCACTGT

NNTGTCTGNGNTTNNNNNTATNNNTNGNNNNNCCG

NCNNNATCTGGAGCTCCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGANTTCGGCACGAGGGTCCTACAAGGTGTCTACCTCTGCCCCCAGGTCCTTNANCA N(^GTTCCTACACNATTGGCCCCGGTTCCGNATTAANTTCTTGGN(^TTTNCCNANNGGGC NNNNACAACαsπSTTTTTGNGGGGGNCN^ GGGGGNCCCANGNTTGGGGGGCNTTACANCTNNCACCNNGAACCAAAACCTGNTNANCC CCCTTAAGCTGGANGNGGATNCCAACATTCAAGCCGTCCGCACCCAGGAGAAGGAGCCG

ATCAAGACCCTTAACACACACAATTTGCCTCNTCTTTATGACAAGGTGCGNCACCTGTGAG CACAAAGAANANGGTNCTTGNAGACACCATNTGAACTCNTGNNCCATACATAAAANNTGT GCGGAGCNANATATACANCATGTNTGTGAGNTATATTNANAACCTCTGTCGGCAGNTGNN AACTCTGNNCCACGAGAAACTNNAGACTGTAAAATGNNGCTTGTCNCATGTAGGGGCTGG TGGGGGACTNTTCAACAACGATTGNGGATGATGATANNAANCNCCANAAATCGNGGAAT

GAATTTTTCTCATCAAANAANGATGTGGATGAAGCTTNTNTGANCAACGTGGAACTGNNG NCCCCCCCTG(^ANGGGCTGCTTGATGGAAAANAACTTTTTCCAGCCGCTGNNTTAAAAA AGAAAATCCTTNNNAAANNAGCCTNACTNTTNTTTTCTTACCCCCNNGGGTCCTTTTTCT^ GGAACAAACAACCCCCANCTTGGANCTTGGATNGGGNTTNATTCCNTTGNNGGGNANNGG GCCCCCCTTTGAAGGAAAANNNCNCNCCCCCCCC(^GNCTTNATACCNAAGNCNTTTTTC

N

NCNNNATCTGGAGCTCCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGANTTCGGCACGAGGGTCCTACAAGGTGTCTACCTCTGCCCCCAGGTCCTTNANCA

NCNGTTCCTACA(^ATTGGCCCCGGTTCCGNATTAANTTCTTGGNCNTTTNCCNANNGGGC NNNNACAACCNNTTTTGNGGGGGNCNNGGCNCCNGNNTNAACNTNGGTNGAANCTNCCG GGGGGNCCCANGNTTGGGGGGCNTTACANCTNNCACCNNGAACCAAAACCTGNTNANCC CCCTTAAGCTGGANGNGGATNCCAACATTCAAGCCGTCCGCACCCAGGAGAAGGAGCCG ATCAAGACCCTTAACACACACAATTTGCCTCNTCTTTATGACAAGGTGCGNCACCTGTGAG

CACAAAGAANANGGTNCTTGNAGACACCATNTGAACTCNTGNNCCATACATAAAANNTGT GCGGAGCNANATATACANCATGTNTGTGAGNTATATTNANAACCTCTGTCGGCAGNTGNN AACTCTGNNCCACGAGAAACTNNAGACTGTAAAATGNNGCTTGTCNCATGTAGGGGCTGG TGGGGGACTNTTCAACAACGATTGNGGATGATGATANNAANCNCCANAAATCGNGGAAT GAATTTTTCTCATCAAANAANGATGTGGATGAAGCTTNTNTGANCAACGTGGAACTGNNG

NCCCCCCCTGCNANGGGCTGCTTGATGGAAAANAACTTTTTCCAGCCGCTGNNTTAAAAA AGAAAATCCTTNNNAAANNAGCCTNACTNTTNTTTTCTTACCCCCNNGGGTCCTTT^ GGAACAAACAACCCCCANCTTGGANCTTGGATNGGGNTTNATTCCNTTGNNGGGNANNGG GCCCCCCTTTGAAGGAAAANNNCNC^CCCCCCCC(^GNCTTNATACCNAAGNCNTTTTTC N

TNNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGCCTGACCTGGCAGGCCTGGAGGCGCTGCGGCGGCGGGAGCAGCTCCCCAGCCT GGCCCAGCAGGAGGACCCAGAAAAGGTAAAACTTCTGCCTGAAGTTCAACTGTGCCTCGA

GACGTGTGCTCCTGAATGCCAGCAGAGCTATGGGAAGGTGGAAAGTACACAGCTCGACAA CGAGTCCCAGTGAGGCCAGCCTCCGGCCTGACAGCAGAGGAACCAACCCAACCTAACATG TCACCAGTGTCAAGGATGCTCCAGGTCCTTGCAGGACCCTGGCACTTCCCACCCAGTTAGA TTTTGCTCGACAAAGCCTCTCTTTCATTCTCCAAAGCATCCACGGGCTTCACATTTCCTCCA GAGGCCTCCCAGGAANAACGCTNGATGGTGTCTCCCTGCTGGCANANAAAAGCCCTGGNA

GCTGGTGGCCTGCACCAGTGCGTGATGTGGGGTGACNTGNCGGCCGGGGGGACCCCCGCG GGGGCCTCAAAAAGCTCANAGAAAGGAAGCNCCNTTCACAAAGATACCTTCCCCCCGCCC CAGCCTGTTGAGCCGNAAACACCCAGCCATCCTGAAAGCCCACAGNTTTGCCAAGGACTT TCCTTGTNGGGNGGGGNCCCCCTTGGGCTTCATTAAAATAAAAAAGTCGTCGNGGCAACC CCCTTNAAAAAAAAAGGNGGGCCNAANTTTNGGGNAAATC

GGACCTTGCCCCCCAATTGGGGGTTTTGCCCGGGCAAGGGGNCCCGGGCCGGGCCCTTCC

NGGGCTTT(^TTTGGGGCACCCCTAATTGGNCCTGGGNNNNGGGCCCCCCCCCCCTAAAC

AAAAAACANGGCCTTTAAANC(^CGGGGGGA(^TTTTTAAαsrCCCCTTTTGGGGGGGGGG

TTNCC(^TTTGGCαSfTTTTCNCCCA

TTNAAAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGGTTTGGTGGACTCAGACAGNCCATAGTGGCCTTTTGACCTTGAGCAAGGGGCTCA ACCTCTCTGAGCTTCTGTCTCTTCTGCAAAGCGGAGCTCTTAATAGTGGTAACCCACAACG

GCGAGGAAGCCAGCCAGTTTNTGGGTAAAACCCTTGGCGTNCATTAAAGCTGATTTCTCCT CACTGGCCCTGTGAAGCAGGTTCAGTTATTACTCTACGAGATAGATGGGGAAGCCAAGGC TGANAGAAGGTTTGGGGCTGGGACCCTAAACACCTGAGTGCAANACTGGCCCCCCTCCAC CGAGGGAAGTGGGCTGAAGCCTGGCCCAGGCGCACCCCTCCNTGGGGAGAGCCTGGGAT GCCCTTCAGCCTTAGTGGCTCCTGACTCATGGAGCCCTCAGCCACCCCAGGGCCCCAGATG

GGGGTCCCCACGGAGGGCAGGGAACGGTCCCCGGAGCCTCCANACTATGAANACNAGTTT CTCCGNTNTCTGNGGCGTGATTATCTGGTACCCGAAGCAGTACCAAGNGGGTCCTNATCG NANCCTACGTGGNTTGTGTTNTTCGAANCCCTGGGGGGCAAACACACTTGGTGTGCCTGG CCGTGTGGCNCANCCCCCNTGANGGACGGNCACCAAATTACTTTATTGGNAAACCTGGTC CCTGGGTTGACGTGCNTGGNGAACGGCCATTTTTGCCTTGCCGGNTAA(_^TTNTTAATAAA

AAAATCACNTGGAATCCTTGGGTTTTTTTGGGCCATTGCCCNTTTGGGAANGGGCAATTCC CCNTATTTTACANGGNCCGGTTTTTTGTTTC^

TTTNTTTNNCCTTTGGGACCCGGTTGGGNTTTGCCANTTTTGGCCCNCCCTT^ AAAAAAACCA

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTTTTTGCCAGCCTCAGACATACTGGTTACATCTGTATTGAACTTTTGACCCTAGAAA CCAATGGAGTTATTTCACCACAAATAACGAATATGCCTGAGGTGCATGGGAATATAGTTA GCTGTACTCTGAAGATACATTTTTTTTTTTTTANCTAGGGCCCNCANCNTNTAACCNNGTA

AAAGNAAAAANCNGTNNNAAANGTNCNTTTTTTNAGTNC^CCAANTGGNAACCNπ NGNTNNGGGGNTAAAANTTTCTTTGGGCCANTTANCTATNGGATTNATNTTNATNATAAN NGGTNATTAAATTTTTTTCOSIAATTTANCCNGNNTANCNA^ CCCAAATNGTANGGTNGCCNGNTTCANNAAAANGGGTNTTNGGNANNANTNTTANAANC CNTNNCAAATTTNANGCNGGANTNNACAACNTCNTCAATTTNTNATAAAAAAAATC

GAACCCAANGGGATNAATTANGGGTTATTAANAATTGGNTTGGANATCNNACNGGGGCA

GGGGGTTCCTATAGGTTTAAATTTTCANNCTTTNAAAAAACAAAAAGGGTTNGGGGAAAT TGGGNANAAATTTTNAAANGGGTACCGGTNTTTTAAAAAGOSrCAAAAATTTTCCCCTTG GAANNGGCCTTTTAAATNCCTTTTAAAAAATTNTNTNNTTπ

TTCCNCGGAAAAATTTTTTTCANGGGGTCAAA^

GCCCCGGGNCCGGGGGGGGNTTGNCCCCANAAGGGGCCTTTGNAAAAAAATTTAANTTA AATTNNT

TTNANCAANCGCTGGAGCTCCACNCGCGGTGGCGGCCGCTCTAGAACTAAGTGGATCCCC CGGGCTGCAGGAATTCGGCACGAGGGTTTGATATACCTTCTATTTTTATGGAGAACATAAG TTTAATTGGTGTTTTGTGTTTCTAAGCAATTGACTAATAAΛACACAAAGTTGGTTAGTAAT TATTTTGTTAACTTGGTGAAGTCAAGTATAACTATTATTTATTACTTGTACATTNGATAAGA AAATTTTCAGATTTTGAATNGCACAGATCACATTATATCTATTGCATTACTTTTCTATACTT

CTAACTGGTCTCTACTCTGGTTGATATTTTTTGTAGTTAACTTTACCTATGAAAACTTTTAA GGGTTTATAAGACTCAACCAGAACTACATATCTGGTGATTATCTCATTAATTAACAGCATA AAATTTATACTATAATGTTTCAGTCANTATAATTCCACTTAATAATTAGTGAAAATTTCAT ATTATCCTAAGTATTACAGTATTAGTCCATTTTTTTCTTCTCCTAAATGAAGGGGTGGTTTA TTTTGGTCTGGGGGTTATATCATTAACCTTCTTTTAATTCTTTTTTGGGCTGGGGG

TTNTANATNACNGACCCCCTCTAACTTACANAGNNANTAGAGACATTTAAAAAAACCTNG NGGGGGGGCCCGGNNCCCCAATTCNCCCTATANGGGGGGNGGGNAAAAANNNNNNNNN NNNNNNNNNNNNNTSTNNNNNNNNNNNGGNC^^ NlSHSrCOWCCONINNANAAANα^^ NNNGGNNNNGGNNNNNNNNNN^ NCCCWTTTNNNNNNNGGNANNNN

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGAATTCGGCACGAGGGGAATATNTTGGTGCCATTTGCTCCTGCACATGCTTTGGAGGCC AGCGGGGCTGGCGCTGTGACAACTGCCGCAGACCTGGGGCTGAACCCGGTAACGAAGGCT CCACTGCCCACTCCTACAACCAGTATTCCCAGAGATACCATCAGAGAACAAACACTAATG TCAACTGCCCAATTGAGTGCTTCATGCCTTTGGATGTACAGGCTGACAGAGAANATTCCCG AGAGTAATATTTCCAACCCAGAGAAACAAGCGTGGATCTCTGCCAAGGTCCATCCAAACT

GGAGTGGTGTTCGCAGACCCCATGTTAGTGTGTTCCTTTCTTAAGCCCTTTGCTCTGGAGT AACTTCTCCAGCTTCAGCTCAACTCACAGCTTCTCCAAGCATCACCCTGGGAGTGTTTTCA GACTTTTCTCATACATGGGAGCAGTANGTTATCTATTCTTCAAAATATTCCATGCCAATCA GTATTTTAAATGAAGTGATTCTAACTTGTGATTNGGATTGGGATCCATAGGGAAGCACATG CACCAACCAAGATACAAAATGTCTTGAAATGATATTACCAAAATTNTAAGTAGGAAAGTT

ACCTGAACACTTCTGCTTNCACTTAACTGACTGGCCCGCAATATTGTANGAAACAAGCATG GTCCTTTGTACTGTGGNATTCAAAACAGCCACAAGTACTCACTTTTTCCAAAAGGAATCTA GTAATTGGCTAAAAAAATCTTTTTCNTTTAACTGATTAATCAAATTTTT TATGGGAAAAAAAATGGACTGAANANACNTAATATGCAGTNGATAANAAGGNAACTGGG C(^AATATGGGGGGGGATATTTTTTATACCGGATGGGNCCAAGCTTTTNTACTGGGGNAA

ANAAACTGGTTTAANT

NCCTACNGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGGTGAAAGGGAACTGTTTAGTTTTAACAAGACTAAGTTAATCATGGGAGCCCTCAGGT

GAAAGAGTTTTAGTAACAACAACTCCTCTTTCCCATAGTCAAGGTGGATTTGTCAGGCCCA CCTGAAATGTGCCCATAGTCAAATCATTTACTCGCTCCTCCTANATCGCTGCCCTTGACGT TTCCCATTGCTGTACGTATTTCTATGTATCTGTTTTTCTCTTAGAATGTCCACCTCTTGGGA CTTGCTTAGATGACTGAATATGAATATTATTGGTATTAGACAATAATTTGCTTTCCATCCA GTATGCTAGTTCTTATTCAAGAACTGTGGTCAGAGGGTATTTGTATATGAGTATCCTTTGC

TTGTCTTTCTAGNACTGAAAATTGACAGAAGTAACTGGCTGTGCAGAATGTAATAGAAGC TTTTCATATTCTTTTATTCTTAAAATCAGTATCTTTTTACAGTATTCTTTCTACATGATC TTTTGTACATTTAAGAATATTTTGATTACAT^^ TAAGGGGTCTTCAAGTAAGTAAAAAACATACATTATAGGGTAGAGGGAAATGGACCTTGA ATTTCTATCTTCTCTCCCACACTAAAGCTGNAAACACTTTGACATATTTTGNNCTGAAACA

CTTGGGTCAAATATATACCTTNTTGGGTTTAAAAACCTGGTNCCAATCAAANTNTTTTTTTT TAAAATTTTAAAAGGCTNGGNGGAAAATNAACCCTTTTTGGANGGAAAAAAGGGGGGCC TCCAAAATTTTAGGGAAGGGATNTGAATAGGGCCCAGNNTTGCMNAANNCNNATANTTAA AATTTTCTNAANTTNNCCNCCCNAAAAAAANGGGGGGNNGGGGGCCANTAAAAAAAAAA AACTGGTTNNNNNGGANCCTAAGGGNNNNNCAANGGNCCCCG

GCCCTATNNGGAGNNGNATCNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCAAAATCAACACCGATGAGATTATGACCTCACTCAAATCAGTCAATGGACAAATA GAAAGCCTCATTAGTCCTGATGGNTCCCGNAAAAACCCTGNACGGAACTGNAGGGACCTG

AAATTCTGNCNTNCTGAACTCCAGANNGGAGAATATTGGGTTGATCCTAACCNAGGGTGC NAATTGGATGCTNTTAAAGNCTACTGGAACATGGAAACTGGGGAAACGTGCNTNAGTGCC NNTCCTTTGACTATNCCACANAANAACNGGNGGACNGATTCTGGTGCTGANAANAAACNT GTTTGGTTTGGANAATCCNTGGAGGGTGGNTTTCANTTTANCTATGGCAATCCTGAACTTC CCGAAGACNTCCTCGATGTCCANCTGGCATTCCTCCGACTTCTCTCCAGCCGGGCCTCTCA

GAACATCACATATCACTGCNCAGAATAGCATTGCNTACATGGATCATGCCAGTGGGGAAT GTAAAGAAAGCCTTGAAGCTGATGGGGTCANATGAAGGTGAATTCANGGCTGAAGGANA TAGCANCATTCACATACACAGTTCTGGAGGATGGTGTGCACAAAAACACACTGNGGAATG GNGGCCAAAAACAGTCCTTTCAGTATCNAAACACGCANGGCCGGCCAGACTACCCTATTG TAGAATATTTGCACCCTATTGANATTCGGGGGGGCCNTGATCAAAAAATTTGGGTGGCCG

GACCATTNGNCCCCTGGTNTTGCTTTTTTTTNAAACCCAAACTTCTTTTCCAA^ CAAAAAAGCCTTCCCCCCTNCCATTATNGTTTCCCTTTTTGGTTNCTTAAATCCTTGGT^ NCCNGCTACCAAGTNGNCCCAAA(^TTCCCANTTTTTTTNTTTTTCCCC^ GNGGAAAAAA AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTGCA GGGAAAAAAGAAGGTTCCTGCTGTGCCAGAAACCCTTAAGAAAAANNCGGANAAATTTC NCAGAANCTNANAATNANCCNACNGAAAANAANNTTGNCCCAAANAANNNTNCAAAGG

NCAGGGNGNANCNTANTTNTTAAAAANCNTANCCTTNCCCCCAGGNATNCCNGCCNANN NNCCNAACNNNAATTNCAATGGNTTNGANGGNNCCAAAAGC(^GTNACTTNTNTNNNCC CNCNGAACCCNAATTGGCGTTTGGCATTCNGANNANANGNATNAATGGTGTGANCCCCAA GGGTCNAAAGGGCTGCANCTTCTTTCCTTCGN(^GATATTTNCGGGGCCTTTTGANNCTCA CCACGGCGTNAATTNCATGCTCTGAANNNTGGAGCCCTACANNNNNTGNGGGNNCACNN

ATNTGAAATCTGTGAATGANNTNANTTACACNCGNGGNTCGNCGNAATCTCCACAAAGCG AATTNCCTGNCACACAANGCATNNATTGCTCNATCTCTTGGGAAANATGGAATCATCTGC NTGGAGGATCTNATNCATGANGACATATNCNCGGGANACGTTTNAAAAAAGCAAACACTT CCTTNTGGNCC^TTAAAANTCTTCTTCNCNACGGGGGGGTGAAGAAAAAAAACCCCCCCT TTTTTGAAAGAGGGGGANGCTTGCTGCCAGNGGAGAACACCTNAA(^GGCTTTTTTATAA

GGANGAACTACNGNGTTTCCNGGAAGATTATTGGNNGTCNGGGTGGTTAAACAACCNNAC CCAAAAAAAAAAAAAAAAANNTNNGGGGGGGGGGCGGGCCCCCNNNNNNNNNNTTTT^ TNNGGGGGGNNNTNTTTNNNNNNNNNNNNNN

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGCCTGCA GGGAAAAAAGAAGGTTCCTGCTGTGCCAGAAACCCTTAAGAAAAANNCGGANAAATTTC NCAGAANCTNANAATNANCCNACNGAAAANAANNTTGNCCCAAANAANNNTNCAAAGG NCAGGGNGNANOSITANTTNTTAAAAANCNTANCCTTNCCCCCAGGNATNCCNGCCNANN NNCCNAACNrWAATTNCAATGGNTTNGANGGNNCCAAAAGCOSfGTNACTTNTNTNN^

CNCNGAACCCNAATTGGCGTTTGGCATTCNGANNANANGNATNAATGGTGTGANCCCCAA GGGT(^AAAGGGCTGCANCTTCTTTCCTTCGNαsrGATATTTNCGGGGCCTTTTGANNCTCA CCACGGCGTNAATTNCATGCTCTGAANNNTGGAGCCCTACANNNNNTGNGGGNNCACNN ATNTGAAATCTGTGAATGANNTNANTTACACNCGNGGNTCGNCGNAATCTCCACAAAGCG AATTNCCTGNCACACAANGCATNNATTGCTCNATCTCTTGGGAAANATGGAATCATCTGC

NTGGAGGATCTNATNCATGANGACATATNCNCGGGANACGTTTNAAAAAAGCAAACACTT CCTTNTGGNCCNTTAAAANTCTTCTTCNCNACGGGGGGGTGAAGAAAAAAAACCCCCCCT TTTTTGAAAGAGGGGGANGCTTGCTGCCAGNGGAGAACACCTNAACNGGCTTTTTTATAA GGANGAACTA(^GNGTTTCCNGGAAGATTATTGGNNGTCNGGGTGGTTAAACAACCNNAC CCAAAAAAAAAAAAAAAAANNTNNGGGGGGGGGGCGGGCCCCCNNNNNN

TNNGGGGGGNNNTNTTTNNNNNNNNNNNNNN

TTGAANAACNATCTGGAGCTCCACTCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCC CGGGCTGCAGGANTNNGGNNCGAGGCCTTGGTCCAGCGCTCGAGGNTGNTCTGCCTNCTG

TTNNATNCNTTNNTTNTTCTCCTACTNGCTGANCGCCNTCGGGGGCAGCTCCGCANCCCGC GCCANGGTCTTCANNNTNANCCNGCANANCTTGNGCNTNGTGGNANACGACGATTGGCTC ANNANGGGNTATCGGTGAGCTCATNGGTAAGNNCATCTATGACTTCTTTGCTCTGGNTATC TTAAAGCTGGNCACTGTGCNGGTTGNTGNNGTTGTGGGCNCCTCCNATGCCCCATGATTTN GCGACANTCCGCTGCAGGAATCTTGCTCCNTCCTTGGGGNTNCGNNAANANCGAGGAGAA

TAAAGAAGAGTTNGANGANCT(^GANGAATGACαSfTGGGCTTTGGNTTGNTTTNACTAGA ATCCCCGCTNCCCTGGGAAATANNACCCCTTTT TGTNAAAAAAAAAAAAAAAAAAAAA TTTTTGGGGGGGGGGCCOSfNNGCCCCNNNTNNCαsrCCTTTTNT^ CCCTTTTCCOSrTNN(^TTNCCTCCANCCCGGNANTGNTTTTNCNTNAACACNGGTGT^ TTTNGNCGTCNNTTTNANNNCCCCC^

(.MSrcαSTGNNGTGGGNACCCNTNCαsπsrTNTNTTTNTNTNCTTGNGGNTTCN

CNAJSfCTGGGGGGGNTNCTCTTTCCCGTNOSfANNAANTANCTNNCTATTNNNTNAATTTCπ

MSTGGGTGTGNTTNGC^CCCCNCAAAATCGT^^

N<_ rTTNTTTTTGNNNN^

TTGANCACAGCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGNNGGAGCAJ AGGGNCCCACCGNCGACNNNNGAGGGAACTCNNTNACTGGNNC CGTGCTCATCTCAGGANCANANCCATTNCTTAGNGAGATAATATAGTATCAAAGCAACAT GCAACCNANACCTTTTGACATTTTAGGGCTAGTTGGTACTTNCCANTANACATGTTTGGTG GCTGGTGTCAAANGTCCGNAAAGNATTAGCTGCCANGNNAGNGGAATGCTTGCTTTTATT AAAATGACTGTANTCTTCCTTGTTNCAGACAAGCTATCATTGGAAACCTCCTTTTACAGTA CAGGGNGNTCAGAAACGTTTTNAGTNCTTTGAAAGCACTATATTTATGTTGCTCCANGGA

GTTGATTTTTCTCCAGGTTTAAANAGAATNACAGCTTCTAACTTTTAATTANAANTGNACA AGACAGAAAGCCCCGNGGANAATTAAAGCCAAANAGGATTTTTCATTNTAATTNTNGGGG GGGAAAAAANATCCCAAG(^TTGTGGANNTAAGGNGTCNCCCCATCCAAAACNNTGTTTC C(^TTGGNTAAAAAAANTCTTTCCTTGGAAGTTTNAAACCTTGAATNGCCCKNAAACTT GGTNNGGNNGGGGGTGNCNCTTAATTTANGGGGGGGGGGGGGGGNGGGTTTGGGGGGGG

TTNAAAAAATNAAANNNAAGCCOTGNGGGC(^TATTTN^ GNGGTTCCCCCAACCTTTTTAGANNGGG(^TTANNNTTGTAAAGGGTTTTTTGCCAA^

ANGNGCCCTTTTTGGGGANNANAAACGGGGGNCCCCAAAAAAANGGGGGTNTTTTNGGN CNAANATTTNAACCCGGGTTNTGGNCCNNCTTTTTAGGNG

TNNANAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCTCACTCCTNTGGTGGANCTCANCACTCGGGAGGCCCTC GTNTNANGGACAGCTGCTTCTCCCGGGCTGGGCTTTTCTCCCTGAGCTGCTCAGCTGGAAC

CAGGGACACGGTCTGAGCCCAACGCCAGTGTCTATTTTCCACAAAAACGGGCAATGCTGN GAGAGCCATCGGAAGACTGTCCTCTATGGCAATGATCTCAGGGCTCAGTGGCAGGAAATC CTCAANAGGGTCACCAACCNGCCCNCTCAATGCATAAAAAACTAGAATCTGANNATGNCT CCCAAGCTTTCCTGAAGNCTGTCGCTGAGGAGAANCCCCATGTAAAACCCTACTTTCCCAN AACCATTTCGTGACTTAGAAGTNGGGAAGGGAANGGCTGCTAAAANTTGACTTGAAAAAA

TGGAAGGATACCCCNGACCCCTGGAAGTCGTTCTGGGTTCAAGGAATGACCCATTCAATT CCNGGGAGGGCCCGGCCACTTTCCANAATGGACTTACGGATGAGGGATGGGGAACCTGGC TTCTTTNAATCATTAATTGAANGTCTGGCGGNGAATGAATGAATGCCCAAGGACNCCCTG GCAAAGNTTGGAAAACAGGNCTTGGGGNAAACCCCCCTGGCNCAACCNNAACNTTATTCG NGGGAAACCCNTGGGAGGGAANGGAAAAAGGAAAAANGGGGGANNAAAAAGGNNGGA

AGGAAAAAATTGAAACCAANAGCC(^GGNGGANAAACCAGTTTTTTAAGGGCGTTNTTAC CAAAAGAACTNTTTTTTTTTTNAAAGCTCNAAAAAAAAAAAAA^ GGGGGGGCCCCGGNCCCCAAATTTNCCCTTTTNNGGGGNG (.MNINNAAANNNGNNNNNTTNGN^ TNGNNNNTTTNGGGANN

TTGGAAACCNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGNTTCCTTATTTNNNAAATNGGNTCTTAAAATAGGTTCATACTATCCTTTGNGNA GAATTGAAAACCTGCAAGAATGTTGTTCATACATATCATGGAAATTGCACAGTAAGGGAG

ATTTTCATGTAAGATTTGTTGAACTANTTGCATTAATTCATAGCCATACTTGATGAATTAA GTCACAGTGGCTGACATTGATTCTGAATAAATTGACCTAAATAAGTANGTATTAATGTACT CTNATCTAAAACTAATTTAGCATATTTGTTCTGTTTTTGAAAGAACAGGAATTGCCCTπ ATACTTGTTTNAAATTTGAGNACCTAAACCTTCACACGAGTATAGATTCAAATGGNCACAT ACATTACTTTTATAAAGNCCGTTATTATTGATTTATTTTAACCCCNAATCTGAGACANATN

AAATATTGNTNTATTTGAAAAATGTCNTTTCTTTCCATTACTGTCATCTNACATTACCCCCA TCTTGAGGGGAANGANTCAGCNCTANGGTGNTTTNATGGATGTGAGTATTTCTCATTTTTA CATAAAACTTCACAATTTATACTTCTCCAATCTCTTACCGAACTTTACANANTTTAAAAAN NANTCNTTTTANGGCCTAN(^ANANNAACTNGNTTTTNTTNTNTGNGANNANCAGNA TNTTTATTNCCTTNATCCCGGCCCWTTTTTATTTTNGACTT^

NNCCCCTGTNTTTTNTTTNNTATTATOT

TTATANNTTTCACTTTGTTTTTATTTANTNANTCATCANNTCTTNCNTN^ TNCTANTATCTCTNTTTCCATNOSINATANATATTNTTATNTCATNTATNNTTT^ CG

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGATAGACTTAAACGAATACATTAACGGTGCTAAACACAGACATTT TAACCCAAGTCACGACATTCTTAGCTGTAACTCAGCTCTCACGGCCTCTTGCTCACCCATG AATGGTCCCGTTTTCCTCTTGCCGCGTGCACCTCCACCCATTGTCTTGGTGGCACATGGGT GGAACACTTGATCTGCTCGAGTCTGCCTTCAACACACATTGCATCTTCAGATTTTCTACTTT TCTGTTCAAAACTAATATTCACCAAGTCAGACTTTGTGTTAATTTTATATCAGGGTATTGG CTGCCAGGGGGTCATCCCTAAGTGGCCTGAAGATGGACAAAGGGAAGTAACAGGCACGT GATGTTGGCAAGGATGCTTCTAGGGCTAGAGGATCAGTGGTGGGAGAGAGCTGCAGAATC

CACCAGCCAGAACTGCAGATAACGAATCTTATGGTCAGGGGCTGTGACTGAGAGAAGGA AACTGAGGTTGTGTTCTGAAAGTACATAAACTCTCACATATACCCAGTTCTTCACCATCTC CCCTCCTCACTTTGCAGTGCCATTTCTTTTTGCATTANGCAATTTGCTCAGACTTTCCAAAG CCATGGCCCATCCGTTCTCTGGAATCCCCCACACCTTCTGAGANGTGGATCACCACGTCCT GCAJSΓGGCTGCTCCCTTCCAAACTACCTTTAAGAAGATGCAGGACAGGGGAGCTGTTTCAA

CCAGAAAGACCAAAATCAANNCCGAGGAGCCAAACGTGGTAAAACAGAAAAANGGCAG GGGGCNAAATGGTTTNCTTTTGGGNTT<_^GGTTTCTTTTT^ CCANANANTNTTTANTCGCNTAACATGGTNCTTCTTTTTTTCCCTTCCCAANTTT^^ TTIAATNAAAAA

NCNNNATCTGGAGCTCCANCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCCGGGC TTGCAGGAAATTCGGGCNACGAGGGTCATGCAGGCCCTGCTGGGCCCGCAGTCCCTGCCT CGGACCAAGGAGGAGAAGCACAANCCAGCCCCCCAGGAGGACTCGGTANCTGCCAGCAA GCAAGCTTCCCCAGCCCCCAACATCAGCAGCGGCTCCCAGACCCCCCGGCGGAAAAAGNC

GCCGTGATCTGTCAGCCACATGTCCTTAGAGGGTCAGGGTCGCGCTTGCCTCTGGCTCTCT GCCACAGGAGGGCCCAGCCGCCGTGCCTTAGCCAGCTGCCATGCATACGCANGTCAGGGN GCTGGCCTGTGGGGGGCGCCAGCCCTTCTGCTTCAAGGGCATCCCCCCACCCCCACCACGT CCGGTCCCAGGACACCCTCTGACCTGCTCGACGGCCCAGGAGGCCCATGTGTGACCTGGC AATCGGGGACCCTTGCTCTNTGCCCCCACGGCAGGGGTCCGAGTCTGAGCCCCAACCCCG

GCTCCTGCACACGGGGTGGAGGTAGGGTGGNATGAAGCTGACCTTGCTTGGGGAGAGGA GGGAANACCCCCANGGTCTNCTCTACAGCANCCTGTCTGNGGTCCGNATCCGTGAACCAA TAAAGGCAATTGTGNCTTGACCCNNNNTGNNTNNANANNAANNAATTTGGGGGGGGGGC NNNNNTNNNNNNNNNNNNNNNNNNNNNNN^

NNTNNNNNNNNNNNNNMWNNNNNNNNN^ NNNNNNI^NNNNNNNNNN^ NNNNNNNTNNTS SINNNNNNNNNNNNANNN^ NNCCN

GNCCTATAGNGGANGNCGNATTNCAAGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGANNNCGCCATNATGNANTTTTGNTGCCCTNAACCTTCAACGAGGNTCNCGGGA

ANNTGANNNACATANTGTNTANNAAATTTCAANANNANCNGATCNTGGATGAANGANAT TANCGCAGGANCNTCCANTGGTNNNCTAANTGGANNCNCAAACTGGTNCNAAANNTNTA

ANN(^TN]SπsπSTAAANCCGATAA(^CCNATATTTNTTNNTACTTCTGNN^ CNNNACNNNATAGCAAGTOSπWGCGNANTNTGANGNTNGACTCTTNNNNANAANANNGA NNANACCATCCNNCATTNNTNATCNANGNAAGGAANNANANGGCNNATCANNTTNAGNG NACNNC(^C^TTTNTANT(^TNGTATTNNGTNGANTNAANNANTNNCNNAN^ NNNACNAAGGNAGAAAAGTNCTNTTNNISINTNNAATAANATNANAGNNTACNNTGTNNT^

ATCATTCGNGCTGCNOSπSINANNlSlNNANAGNTATNTGNNNNTNTNNTNGANTGN^ GNAAGNNNTANANTNNACTCACNGTAAAGNANNCNNNTCNNTCTCCTAGCANCNTTTCGT NACCAANNCCTCCTCNCAAAAGNAGNATNTAANGANATGATGCNAANGCTCNCCAAACN NNATAACATNNTAANCNNCNNANANTTNATCANTANNCATNTNNANGTNNGNNNNCCAC ATTCCCATATCATATACCANNNTTTCTCNGNCCTGNCCACGANGTTTNTNATANCAATNTN

GNNNNCCANNTGNl^JNNCNTNTNTNTNATNCANNNATNNAAAGCC^ NTNTTTCTTNTNTCNAANTNNCNN^

NNATNNTGNNTCCNANACNGNCGANCTNNNGNCCACGNTNNGANACGGANCNCGNNTCA TANCCATCANGAANCNACGTCNATATCGNCCTCCNTCAANTNGACATNNNNACGTNNNCT TTCAGNTGNCTCGNTNCNCMNATGCGNGNTACTANAGANTTNNNNTGNCGNTNGNCG

TTNAGNNTATCTGGAGCTNCACCNCNGTGGCGGCCCGCTCTAGAACTAAGTGGGATCCCC TTTTTTNNTTTTNAAANC^

CCCCCCCCC^GGNN^

(^AAANπSTGGGCCCCGGGGGGGGNNNTNNNTTT^ AAAAAAANNCNNTNNGNNTNNAAAAAAANNNNNGGGGGNTTNNNNT^^

TNNGGGGNNGGGGGNNTNTSrTTTTTT^

NNAAAAANCAANNGGGNTTNTTTTNGAAAAAACCCCCCCH TTTTTANTCCCTNGNGG

CCANAAAANGGGGTTTNNNNNAAANATTNGGCGGGGNTTT^

CCCCCCCCAAAAAAAAAAAANGGGGGGNNTTTTTTTTTNGGGGGGAAAAAAANGNCCAN AAAAANNCCCCCCTTGGGNGGGGGTTTTTTCNCTGGGGGANATTTTTTT^

AAGATTTTTTCTNAANTTTTGGGGGGGTTNTTNNNNGGNGAANNAAAAA^

TGGGTTNTAAAAAAAAAAAAACCCCCCCCCCCCCCCNNTTTTTTNGGGGGNCCCNAAAAA

CNAAAGGGGGGGGGGGCCCCCCNTTTNANACNCCCCCCGGGGGGGGGGTTTTTTTCNCCA

NGNGGGGGGGGGGGNNCGC(^C(^TNNTTTTNTTTTTTTT^ ANNNNNCCN

TTNAGNNTATCTGGAGCTNCACCNCNGTGGCGGCCCGCTCTAGAACTAAGTGGGATCCCC CGGCCTGNAGGTCNAGTTNTTTTTTTTTTTTTTT^^ TTTTTTNNTTTTNAAANCNNNNCCNTTTTTT^^

CCCCCCCCCrøGGNNlSINCNNNNNNNCCN^ C AArWGGGCCCCGGGGGGGGNNNTNNNTTTNNGGGG

AAAAAAAAAAAANNNTTTNCCCCCCCCCCCCCAANTTTTTTNNGGNGNCCCCCGGGGGNA AAAAAAANNOSINTNNGNNTNNAAAAAAANNNNNGGGGGNTTNNNN TNNGGGGNNGGGGGNNTNNTTTTTTTNGGGGCC^

NNAAAAANCAANNGGGNTTNTTTTNGAAAAAACCCCCCCNNTTTTTANTCCCTNGNGGGG

CCANAAAANGGGGTTTNNNNNAAANATTNGGCGGGGNTTTTNTTTT^

CCCCCCCCAAAAAAAAAAAANGGGGGGNNTTTTTTTTTNGGGGGGAAAAAAANGNCCAN AAGATTTTTTCTNAANTTTTGGGGGGGTTNTTNNNNGGNGAAN^

TGGGTTNTAAAAAAAAAAAAACCCCCCCCCCCCCCCNNTTTTTTNGGGGGNCCCNAAAAA (^AAAGGGGGGGGGGGCCCCCCNTTTNANACNCCCCCCGGGGGGGGGGTTTTTTTCNCCA NGNGGGGGGGGGGGNNCGCCNCCNTNNTTTTNTTTTTTTTTTGNGGGGGTNT^

ANNNNNCCN

TTNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCAGGATCAAGCGATTCCTGGCCAAGAAACAAAAGCAGAATCGTCCCATTCC TCAATGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATTG GAGAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGTCTTAACA

TGTAGACCACTTTTTTAAGCAGCCAGATCACAATGAAAACATCACTACTGTAATGCTTGGC CCATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCAATAAATATAAAACGTTGCAAA AAAAAAAAAAAAAAJSINTGGGGGGGGGCCCGGNNCCCAATTCCCC(^TNNNGGGNNCΑSLN NTANAANNNGANNNTANCATTATTGGNTGCNNNCTGATAAAΑSΠSFAACCATTTGCAAACNT GCCCTTANNGGGA(^TTGNTTTGNTCTTTGANGNCWTTNACCTTTGNNGACCCTNACCCCT

NCAACCANCANNTNATNCATTACCTNCCANNCCCANTTTNCTTTTTGGNAAAANTANNGN GGCCTGGNNNNTGGGANCCCNNCCCTGGGCTNAAGNGNNANNNNTGNTNTTGNNMSINNN GNNCANNNGGNNANAAAAANTACCTNTN^ NNNNTSIMSINNANTSΓNGNNNCCTANNGNNNTTNGGNGGGNTNNNN^ NGGGCCNNN^TNNNRWGGGNTNGGNNNNNNNAAN

TNNNNTNG-WCNAN^ NNC( 1SINNN(^TTTNNGGGGGNTTNTNNNNCCCNTNNCCNNGG

TTGAAAAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCT

GCAGGNANNTGCTGNNACGCTCNGNCCNCTNGGNTATGTTNGCTCTCNCGNNGNNGNTGG ANTAANTGNNNTTNCNTGNCC(^T(^TGCCCTTTGGTCCTTGAGGTGNTACTGTGGANNCT GGNCCTGNTGNTNCTCCCNGCCCTACTGNANNNNTTGGACANCNAGGTCNTNNCTGNGNN NGCTATNANTNGACTNTCCTGNCNNACCCANATCNAAAGAANGATCACGATGGAGGCCN CNACNANNGNACTNANGATGCCNCTGAGNGCCGAGACCGTNANCTCNNGGTGGCNCCCC NCTCNTAACCGTNNGCTGN(^GNTNGAAAACANCCGNAGCCCNNAANGGNNTTTTCNAA NAA(_NCTGCCGATNATGACGTGACGNAAGNATGTGCCCTTTGATTGGCNTGAACCGNTNA TGTTGCTGGACCCTAANAANGGTTGGATCANGATGCCTNNNGGTTTTNGGAACCTGGCAA CCCGAGANAACTTTGGATTACNCANNGAANCCATTTTΓGACCAATAANAAATGGTTTTTTG

GGGNNNNAAACNCCAAGGAAAAAAAGGCAGGGNTGGTANCCNGNNNTNGNATTAAACC CCCTTTTTCCAANTTTANGTTTNTTGGGGGGANACGGTTTCCGAAACTTGGCAAAGGGNNA NCGTTTCAAAATTAATTTTTCTTGGACACTNGAANTCCAACCCCNGGGCTTTANAAAAANT TTTTACTTTTCTATTTGCAAAAAAAAAT^^ GNANCCNTTCNGGANGGGGGCCTTCTTCCCCCAAGGGTTTCCCATTNNAAATGGGGGNTT

TCGGCCCNGGGGGNNAAAANNNCGGTTTTACCTTAAAGGNGNGNACCTTNAAAANGGGT NGCCNAAATCCCCCCGGGGACCT

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCTTCGCTGGGGTCTGAGCCGAGCCGAGGCCTGGCTGC TCCCGCCGCCCACAAGCTGCTGTCACCGGGCTCTGCACAGACAGGTAGAGGGCACCGAAT TCCGGAGCGCCTACAGCCTGGACAAGCTGTACCCGGAATCGCGGGGCGCGGACACCGCCT GGAGGGTCCCGGGCGACGCAAAGCAAGGCAACGATGACATTCCTGTAGATCGCTTGACGA TATCTTACTGTCGGAGCAGTGGTCCTGGGGGCCAGAACGTTAACAAAGTGAACTCCAAGG

CTGAAGTCAGGTTCCACCTGGCAAGCGCCGACTGGATCGCAGAGCCCGTGCGGCANAAGA TGGCTCTCACGCACAAAAATAAGATCAACAGGGCGGGAGAGCTGATCCTCACGTCTGAAT ACAGCCGCTATCAGTTCCGAAACCTGGCAGATTGCCTCCAGAAAATTCGAGACATGATTG CCGAGGCCAGCCAGCCAGCCACAGAGCCATCCAAAGAAGATGCTGCACTTTAAAAACTCA GGATAGAAAACATGAATCGCGAAAGGCTCCGAAAAAAAANAATAAACTTTTGCCATCAA

AAACNAGCANGGAGGGTCGGTACCGGACTTGAAAGCACCCCCTTNGAGCCAGCANAANC CCCTTCANGGGCANCCCANGTNGGCTCGGGACACCCAGGAAAAACGGGNGTCTGTTCGGG NCANCTGGTTCGGNNTTTTACGTNGGGAACCCGTNNNAAANNAAGGNNCCNTTCGGGAA AACCNAAGGGTTTTAAGGCCCCTTGGTCCCCCCCAGGGNNTTTTTAAAGGGGGNAATNNC CGGGTTTTTNNC(^CCCTTTGGGTAAANCCCANGGNCCCGGGNTTAAANNGGCCATTAAA

AATTNTTTAAACCC<^AAAAAAAAAAAAAAAAAAAAAAN

TTGANCAACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCTTGATTTTTAGAAGAAAACAGCCAGACTGAATACCACCCAGTGACACCAG

NGCAGGTAATAAGCACCACCCATGTTGCACGTCAGGCACACTTAATCCTCTACCCTACCA GGAAGATCGAAGAGTAATTTGTTCTGGAAAATAACTATTATCTTGTCTGTTAGTTCATGTA TCATAAATCCTATAACTGTATGTGGCTTTGCTGCTTATTCTTACACTTTCATCAGGTCCCAA AGACATATTTCCTCAGCACTGACAGTGTTACAGGTACAGTGTATTGTACCTGTAACAATCT TCACAGGTTTTTTGCTGTATATAGGATACGGTCTTTTTGCTGTATATAGGATACAGTCAGA

TTATTTGATTCTATATACATTTTAATTCAGTTCAAAGGACCTTTTAAGACAGCACCATTT^ CTCACAATATAGACTTTGCTGGTTTCCAGCACATGAAATACATCTCCTGACAGAATATTTT AATGACACATGATAGGGTGTCAGTCAGCTGATCTGTCATTAGCTTGTATATTTCTGCCCGA GACCAGTCCTTAGTATTCCAGTACTGATTTCAGGCAGCATGTCTTCTGAATGAATATCCTC AGCAGCCTACTTGNTAGCATGTATTTATTGNCATCTGGTTANAAAACAGTGAGCCCCAAG

NGATTACCGGNCCTTGNTTCAGTCCCACTTATTCAGGAAANGGGAATNCCANAATCATGG ATCCCCCAAAAAAACCTCGCCCCTTCCANNGAAACCGACGGGAATGGGAAATGTGCCCTC CANAAANTTTTTGGGGAAAANGGGCTTGGCAATCAAATCAACNTGGNACTGG

NNCCNTCTANNTCGTAAAAAATNNTTNCCCTCNNCCNCCNCCCCCCCAACCGCTCCNCCA ACTCATCTTACOSIACCTCCCCANNGNNNNNNNNTNNNGTNCTCACTNCCCTTGAGNNNCA ACTGGACTCCACGCGNGGGCGNCCGCTCTACAACTAGTGGATCCCNCNNGCTGCNGNTAA TTCNGACNCGAGGGNTANACATNCTGCCTCCCCCTACTCACNTNNCTNTTNTAGGCCTTAT TACGGACNAANGGTTANTTACTOSINCTTTCCTNTNTCNTTNTCACATCGNNNNACNNTN^

ATTNTAANANTANTNTTTANATACCTNNTNAACTANAATCCATCCN(^TTNAATNNTNT^^ NGNCAAAATATNCATTNNTANACNTANTTGT^ ATTNNNCNTNTNAAANNNTTTNNTN^ ANNTTCNTTATATNNTTTTATNTGGNTOT NTANAANTACANAGACANT(^TTCTTATTTACCTACTNTTTTTCTCNCCCATA(^TTNANT

CTTCCTTCATNTAANNCTACANCNTNCAAATTTTTATCATANNTNNNTCTNTNN^

GTNTTATCATNNNTTNCCNGC A<^^

TNNNCANCTNNGCTACNCCTAATCTCCCTNTNNTNAANGNTTTCAAACNANNTTNATANTT NATTCCCANTATANNCTACTTTNACAANOSINNTCCTATTNTNNTNATNTN^

NTTNTTCTATCNNTAATNNANANNNNT^

NAANNTANNTCAATNGANNAT^CGTTTTTAπ^

TANANTANNTTTNTCTTTTTTTCT^^

CTGNTCNATCTNTAANATATCT(^CATATACTNTGTNNNACTNNNTCCTCNTATCTTATAT TANCTCANTTACNTCACTTTCNTCAGNNNTTNCATNTATNGTTCCAACNTACTNTNTATNT

GATANTCTNTNCACTCACANNTCACNNTCTNTCACANTTCATATTATTACAATATACNNCA

CNNATA<_MNNNANTCNCTNNCATNCTTACATTTNTGTT(-^

NATTNTGAGTNNTTATNTATCTTOSfN^^

T ACTNTNNATATATNTNNTNTCANGATTNACTANNNCNTNTTTTATATATAAN^ ANTTNGTCCTATNACTCCOTCTNTATANC

CTTNTCTNTTCTCAATCGNTCCGACNNTCNACCCANCTNTTCACTCNNATATCGNCTGACN

CTGCANGTTTACTCTNNATCCTCTACC

AAANCTGGAGCTCCCCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GCTTTTTCACTTTGCTGAGGCCAAGTTCACAGCAGGGGACTTCAGCACCACAGTTATCCAA AATGTAAATAAGGCCCAAGTGAAGATTAGAGCAAAGAAAGATAATGTAGCAGGTGTTAC ATTGCCAGTATITGAACATTATCATGAAGGAACTGACAGTTATGAACTGACTGGTTTAGCC AGAGGTGGGGAACAGTTGGCTAAACTGAAGAGGAATTATGCCAAAGCAGTGGAACTACT GGTGGAACTGGCTTCACTGCAGACGTCCTTTGTTACTTTGGATGAAGCTATTAAGATAACC

AACAGGCGTGTAAACGCTATTGAACATGTCATCATTCCCCGGATTGAACGTACCCTTGCTT ATATCATCACAGAGCTGGATGAAAGAGAGCGAGAGGAGTTCTACAGATTAAAGAAAATA CAGGAGAAGAAAAAGATTCTCAAGGAGAAGTCTGATAAGGACTTGGAGCAACGGAGGGC AGCCCGGAGAGGTGATAGAGCCTGCTAATCTCCTGGCTGAAGAGAAGGATGAAGATCTTC TGTTTGAATAAGCTTTCCTGCTCTGGTTCTTTCAGAAGGCCTAACATGTCACCATTTTAATT

CATGGGTGTGTANGGTTTGTTGNATGGGTATTTATTTTTTGGCTTAAGAATTCCCCCAGTTG NAAAATTTCCCCTGAATGTCTTGTTTATGGGATCTACGTTTGCANAAATCATAATTAANCA ACAATTTATCCCCCAATGAAANTTTGTAGAACCTGTCCCCAAACCTGTAAAATTTTTGCCT GNr^NNAAGGGN(^CCCTTCTTTNANTTT^^ ANATANAAAANAAACCCCTTTTTNGGAACCANTNNTNCTGGCCNNTTNNTCCCAAANNCC

CTTTGNTNCCNCCGGCCCCCN

NCNNNATCTGGAGCTCCACCGCNGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGANCCCNCCNTTCNNACCGAGGNGCCCCTNNNNNCCNACGNCNNCCGNNANAANG

TGACCCACATNATGTTCNAAACTNTCNNTGNCNCAACCGTGTATGTGGANATTCAGGCGG AGCTNCCCCTGNACGCCNCTGGACNCACAACTGNCNTNGTGCTNNACTNTGGAGANGGCN TNACCCACGNNGGGCCCANNCATGAGGGNTACNNCCTGCCCCACCCCATTNTNCGNNTGG ACCTGGNTGNNCAAGATATCANCGANTACCTCATNAAGANANTGACCGAACAAGGCTNTT ACTTCTTGACαsrCCGNTGACCCTGACATTGTCCNTATACATCNNNGNGAAACTGTGCTTCG

TAGNCATGTACTCTGANAATGATATGGTNACTGNCGNATCTCTNCTCCTCCCTGAAAAAG ANCTATGATCTGCCTGATNGGCAAGCGATCACCATCANGAATGANCGTNCNCGCTGCNCT GANACCCTGNTCCAGACCTCNCTCATAGNNATGGNNNTATGNTGNCATACTACGATACCA CCCNACAACNTAATTCATGANGTGTGAANATNGGCTATACAAANANGNGACGCTCTTATG CTNAACAATCGTANCTTCTTNN(-MSrGGGTACCACCATGGTAC(-^CATNANCTTTNNT^

CGCAATGCCTTNNGGAANANCACGGCCCATGGGNCCCCNCGGNCNATGANGNATCTNGG NATNATNCCCCCCTTCCCGAGC(^CCAAGNTNCTTCCTGTCKNGAATTTGNTNGGATTGCC ATACCNAGGNTCNTTCTTTGNNNCACCCTTTCCCNCCAAANTTGNGGGAACCCCCNAANC AGGAAGTTTCNAACGGAAGNCCCGGNCCαS[TTCCTTNTTNCCNCCCGNTNAATGGGTTTTT TCCCCNCACCCCCCCCTCCCNCC

GCCTATCTGGAGCTNCACCNCNGGNGGCGGCCCGCTCTAGAACTAGGTGGGATCCCCCGG NCTGCAGNANTTCGGCACGAGGCGACGGCGGCAGCGGGCGNAACGGGACTGGAGGNACC ANCGGAANGNAGGNGGNTNCTGCAGCCGNCCCNANNGNNANGNCCTCNGAAGGNNCNG NNANGGTTNAANC(^TTNTTNTTCC<^TR^

C^TNCCCC INCNQSRGAAGGGCNGGCNANNCCAGNGAATGGGGCNTTNAANNG AAGGCCCAAATATTGAAGGGAAGAACNTCTTTCAACNGCTGTCCCCACCNTGGAAGAANA ATTATCATTGACACAGGAAATTATTACACCCCGGAGGAGCNCTNTANACACGTNTTNACA

GGAGCTCTNGNNTCTGNGTTGGNATACNNCANGGGGGCCGCCTGANCCCTCNGACATANA (^TGCATATACANGTGTGCGAGATAATTNAGAGCCCTCTGTTTCTTATATTGAACCCTATA CCACCCACACANATATTTTGTCAGNGTCNTTGAGACCGCCNTATATATAATCAANGGNGA GCCNCCATGCTGCTGGCTGATNTGANCTACNCTCTGNNCACCAAAGAAGNGGCACGCCTN TGTTGGTGGACCACNTNGTCCCGNATGANAACAACANGCAGGGGGAGAAAAACTACCCT

GGTTAAGGNNGGGTTGCATGGNGCTTTCCTTCCAAAAAAAAGGGGGGGGGGNNNNNNNN NNNNNNNMSΓNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNCT

GCCTATCTGGAGCTNCACCNCNGGNGGCGGCCCGCTCTAGAACTAGGTGGGATCCCCCGG NCTGCAGNANTTCGGCACGAGGCGACGGCGGCAGCGGGCGNAACGGGACTGGAGGNACC ANCGGAANGNAGGNGGNTNCTGCAGCCGNCCCNANNGNNANGNCCTCNGAAGGNNCNG

NNANGGTTNAANCCNTTNTTNTTCCσSITNNNNTTTNTAAαsπS[T^^

(^TNCCCαWCNNGAAGGGCNGGCNANNCCAGNGAATGGGGCNTTNAANNGGAANCCAG AAGGCCCAAATATTGAAGGGAAGAACNTCTTTCAACNGCTGTCCCCACCNTGGAAGAANA ATTATCATTGACACAGGAAATTATTACACCCCGGAGGAGCNCTNTANACACGTNTTNACA GGAGCTCTNGNNTCTGNGTTGGNATACNNCANGGGGGCCGCCTGANCCCTCNGACATANA

CNTGCATATACANGTGTGCGAGATAATTNAGAGCCCTCTGTTTCTTATATTGAACCCTATA CCACCCACACANATATTTTGTCAGNGTCNTTGAGACCGCCNTATATATAATCAANGGNGA GCCNCCATGCTGCTGGCTGATNTGANCTACNCTCTGNNCACCAAAGAAGNGGCACGCCTN TGTTGGTGGACCACNTNGTCCCGNATGANAACAACANGCAGGGGGAGAAAAACTACCCT GGTTAAGGNNGGGTTGCATGGNGCTTTCCTTCCAAAAAAAAGGGGGGGGGGNNNNNNNN

NNNNNT TSlr>fNNNNNNNNNNNNNN^ NNNNNNNNNNNISIN^ NNNNNNNNNNNNNNN^ NNNCT

TTNANNACNNTCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGNNTNNATCCNTGCNCATCCNAAAGGATGATGAAGTTCAGGTTGTACGANG

GCNCTACAANGGGCAGCAAATTGGCAAANTAGTCCAGGTTTACAGGAAGAAAATACGTT NNTCTACATTGAACGAGTGCATCTGGGAGAAGGCTAATGGCACAACTGTCCACGTGGGCA

TTCACCCCAGCAAGGTGGTTATCACCANACTAAAACTGGACAAAGACCGCAAAAAGATCC TCGAACGTAAAGCCAAATCTCGCCAAGTAGGAAAGGAAAAGGGCANATATAANGAANAN ACANTTGAGAANATGCATGGAATAAAGTCATCTTGTCTACAGCTTTCATTAAAAACTGTTA AAATGAAAAAAAAAAAAAAAANNTGGGGGGGGGGCCGGGACCCNNTTTGCCCTTATNGG GNGTGANAAAGNTNNCGATGGTGGCCGNTTCTACCGGGCTGATGATGCCAATGTGGNCCG

TGACCGTGACCTTNAGGTGGACACCACCCTTCAAAANCCCTGANCCAGNNGATCGAGAAC ATCt^GAGCCCTTGAAGGOSINNCGNAAGAACCCCGCCCCCNCCTTNCCGTGACCTCAANA NGTTNCCCCNTTTGACTGGAAAAAACGGANAAATACCTGGNATTGACCCCCAACCCANGG NTTGCNANCCTGGATTNCCCATTTAAGGNTNTTTTGGNAANNATGGGAAACCCGGGNGAA AACCTTTGTTTTTCCCCCCCCTT(_ CCCAN^

NANCCNNGAAACCCCCNANGGNAAAAAAAGGCCCNTTNTGGGNACCGGGNNAGAGNCNT

NNACCCGNCGGNATTTNCANTTTNNNNTTTC^

NTTTTNGNCCNTCOSINNTNNANTTTTCCTTGNCC

TTNAANAAAACTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGC TGCAGGAATTCGGCACGAGGCAGGCAGTCGTCAGTCAGGTGCTATTGTGTCCTGGGGGTG GGAGGGCCTCCTGAGGCTCTGCCTGCCTTCTCTTCAGCCCCACTGAGCGTCAGCCTCGGGG TCTCCTGAGTCAGAACCCTCCCTGCTGTCTCTGGTGGTCACTCAGGGCTTGCAGGTGACCA CAGGCCCTCCCTCGANAGGAGGGGCTGCCGATGGNATCTCCACACATAGGCACTGGCGGT TGTTCCGCTTGTCCACCGACCTTACTCCNTGCCCGTCGTCTGTCTCGGCCTGTCTGGGAATC GCCAACAANAGCGGCTTCTCACGGGCCCTTGGTGTGGTGGTGNCCGCCTTGGGGTTCNTTT TTTTCAAANTAAGANGCGAACCTGCANNCAGTAACCCTTGCACTTCCTGCAAGGACAACA AANNGNGAAGTCACTGNGAACAAG(^TTNTTAAAAAAAAATCTGAAAATAGTCCTAANT

GGCCAAAATGGTTTAAACGAAAAAAACATTTGACCTTTGGGAAAGAAAGGGAACCGGCN CCAAAAGGTAGGGGGGGGCCATTCCGGATCCANGGGGTCAAAANGGCANTTGGCACAAC CGGCCCAATGTGGCCTGGTTAANCCCATGGAATNTGGGGTTGAANCCTAANTTCCCCCCCT TACANTTTTACANAACCAAAAAAAAAANCCTTTTAAAAAAAGNCCCTTTTGGGCNTANAT TCNCTNGAATTNCNTNGGGGCANTTTGGNNAGCCA^

TTTCCTTAAAAATAAAAAAGNNNNGGGNAAAATTTTTAACTTTTAAAGGCNGGGNGGGGN

CCAAAAAAACCTTTTGGNNNNAAAAAACTTTAAAAGGAACCNT^

NAANGGNNNGGGGNGGGNAAAAAAAACCCCNNNTT

TTNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCTGCAGGCAGGTTGTTGGGTTTCGAGGCCAACGGGGC CAACGGGTCTAAAGCAGTTGCAAGAACAGCAAGGAAAAGGAAGCCTTCTCCTGAGCCAG AAGGTGAAGTTGGGCCTCCTAAGATCAATGGAGAGGCCCAGCCGTGGCTGTCTACATCCA CAGAAGGGCTCAAGATCCCCATTACTCCTACATCCTCTTTTGTGTCGCCACCACCACCCAC

TGCCTCACCTCATTCCAACCGGACCACACCGCCTGAAGCGGCCCAGAACGGCCAGTCCCC CATGGCAGCCCTGATTTTAGTAGCAGACAATGCAGGGGGCAGTCATGCCTCGAAAGATGC CAACCAGGTGCACTCCACCACCAGACGGAACAGCAGCAGTCCACCCTCTCCGTCCTCTAT GAACCAAAGAAGGCTGGGCCCCCGAGAGGTGGGGGGCCAGGGGGCAGGCAGTGCCGGAG GACTGGAGCCAGTGCACCCCGCCAGCCTCCCGGACTCCTTTNTGGCCGCCAGCGCCCCACT

GTGCTTGCACCCTNTGCCATGAACCGGNTGGAGGACACCCACTTTTGTGCAGTGGCCCTTC TGTTCCTTCGCACAAGTTNTGCTTTCCCTTGCTCCAAAACAAAGCATTAAAACAGCANGGG AACTAAGTNGGAGAGGTCTATTGGTCCCAGTGGGGGAAAAAATGCCCTNTTTGNGGGCCT CCAAATGTCCCCCTGGGNCCTTTATTGCAANGGGGAAAATTGCAANCCTTTCNTTNGNTTG GANAATTTGAAAGTGNAAAAAAANAAAAAAANACTTCGGGAANTTTTCGGGTTCAAAAA

AAANCCCCATGGANTAAATCTTTAACTTAAAACTGGGTTNGAATTGGATTTTATATTTTCC CCCTTTTTTTTTTTTTNTNC

TTNNNCAAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGCGAACAGTCCTCACGCCGATCTCTTTCCTGGTTCCCACCCGCGCCAGGTGACN CGGAGAGCTGACACCATGGTTNATNAGGNGCTCTACCGGNCGCTGGTCTCCACCAAGTGG NTGNCGGAGTNCGTCCGGGCTGGNAAGGTGGGCCCTGGCCTTCGGGTGCTGGATGCGTNC TGGTACTCGCCGGGCACCCGCGAGGCCCGCAAGGAATACCTGGAGCGCCATGTGCCCGGC GCCTCCTTTTTTGACATANAGGAGTGTCGGGACAAGGCCTCGCCTTACGAGGTGATGCTGC

CCAGCGAGGCGGGCTTCGCCGACTACATGGGCAGCCTGGGCATCATCAACGACACGCATG TGGTGGTGTACGATGGTGACGACCTGGGCAGCTTCTATGCACCGCGGGTCTGGTGGATGTT CCGTGTGTTTGGCCACCGNACCGNGTCCGTGCTCAATGNTGGCTTTCCGGAACTGGCTGAA NGAGGGCCACCCCGGTGACATCTGAGCCCTCACGCCCAAAAGCCAGCCATCTTCAAAAGC CACGCTGAACCCGCTCCCTTGCTCAAAGACCTACGAACANGTGCTGGAGAACCTCGAATC

AAAGAAGGTTTCAACTTGGTGGAATTCACGGGCCCANGGGCCGGTACCTTGGCCACACAA GCCCGGAAGCCAAAATGCAATAAGGAACTTGGACTTCGGGCCACAATNCCAAGGCTTNGG N(^AACAATGCCCTTTTATTGAACTTTCCTTAACGGGAGGAATGGGCTTTTGNAAAAAAA ACCCCAAAAGGAAACTTCCCGNGNCCATTGTTTCCAAGGGCCAAAAAAAGGGNGGANCC TTTAANAAAAGNCCCCTTTATTTGGCCACAATTGGCCCGGGAAG

GGAGCTNCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGAATT CGGCACGAGGGNCCTCANCCTNTTTTCCCGGCGCCCGATGCTCTGTAAGAGCCTGCTCCCC ATNGTGGTCNAGCATGTGACGAGCCACNCGCGGNCCCGCCATNAGGTCCAGGCCTGCCTG

CTGCTCCAGAAGACCCTGCCCACACGGGAGCTACGCGTGTGCTTTAAGGACCCAGAGNGG ANGCAGCCTGATGGGCCAGACCCTGGGGAANGTCACCGATATCCTGCTGACGCTGCCAGA GGCTGAGACCAATGGCAGGGNACCANAAGGATNTGGNGTCCTTGGAGCTGCTCANCACTC TGTTCAGGAATTTCCATCATGATAAGNTGACCATGGACCTGACCGCCGTGCTGGGCCGTGC TGCANAGCCAGCAGCTAANGCTGCAGNANAGGCNACAGCAGGGGGAGCACTCGGGCGGA TCαS[GCCGNCTTCACGACCTATACTGGCNGGCCATGAAGTTTCTCGGAGTCCAGCGCCCCA AGTCAGAGAANGATACCAAGGAGGCCCCNTCAGGCCACACAGNTAGAGCCCCAGTTAGC ATGANNCGGAAGAAAAAGGGCTTCTTGCCAGAGACCANTAANCGCAAGAANCATNAANC CNTGNAGCCACCACTCCATNGAGGCGGCGGGCGGCTNAANCCCGAAGCCACCAGTGGGG

GACCATCCCCCOSINCGCCGGCCTNGAAGAATAANAANTAANNAAGNNNATGAATTAAGA ACCATNTTCCCCNCCCNCTTGTNCCCAAATGAANTGGGGACANCCTGGTTGCCAANNANT CNAACCCATAANGCCTCCTTGCTGGNNAGCCCCCNNNATCCCCTANCCANATACCCCNAA TNCCCCCAGAAAAAANACCCAAAANTCTGGCCCANNNANAACC^AAGNαSfNTCCCCTTG GCCTNANTAAATNCCCCCCGGGGNAGCCANTGNTCCTAAAAACNTNNCAAAAAACCTACC

CCNAAC

GCNCTACTGGAGCTNCATCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAAGGAATTCCGGCACGAGGCTCGTGTTCCGTGTCCTCCCGCGCTTCTTTGNTCGCTCTTC

CGCACCCCGNGGCCCGTCTCCTCCATCGATCGCCATGGAAGAAGAAATTGCCGCCCTCGT CATCNACAATGGTTCTGGCATGTGCAAAGCTGGCTTTGCTGGGGATGACNCCCCCCGGGC CGTGTTCCCGTCCATCGTTGGGCGTCCCCGACACCAGGGCGNNATGGNGGGCATGGGGCA NAAGGACAGNTACNTGGGCNACGAGGCCCATAGCAAGCGTGGCATTCTGACCCTTAAGTA CCCNATCGAGCACGGNATTGTCNCCAACTGGGACGACATGGANAANATCTGGCACCACAC

CTTTTACAACGAGCTGCGTGTGGCCCCCGAGGAGCACCCCGTGCTGNTGACGGNGGCCCC TNTGAACCCCAAGGCCCAACCGTGAGAAAGATGACCCANATCATGTTCGAGACGTTCAAC ACTTCΓΓGCCATTGTATGTGGCCATCCAGGCTTGTGCTTTNTTTTGTACNCCTCTGGCCNGC ACCATTGNNNTTTTCATGNCCTCTGGGGACGGGGTNCNCCCACACGGGGGCCCANTCTTA CGNGGGGGNTCGCCCCTCNCCCCCACANCCATTNCTTGNGGTTTGNAACCTGNCTNGCCC

GNGACCCTGAAAAANTTNNNNTNNTGAAANATCCTCNCGGGANCGTTNTTTACNGCTTTA A(^CCCCAACCCGGNCGGGNAAAATTNNTCCTOSINNAATNNAAAGANAANTNLTNNGTTC CTNNAGCCTTGGNAATNNNNNACAAGNAAATGGGCTTTNCGCTNGNNTTTTTTCΠ^ TTTGGAAAAAAANCTTTTTANCCTTTCNNAAGNTGNTNNGGTATNCNCCNNTTGGCNAN^ GNTNGGGTTTCNGGTGNNCNNNNNTNTNTTTNNTCACCCACTTTTTNANGGGT^

CCTACCC

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGGTGTATTTTAATATTTTATGAATGCCTTTTGTTCTCAATTTTGA

GGCATAAACTGAAATTCTGAACCTACTGGAAAAGACTTTACTTACTTCTTGATACACTTAC AACAAGCCTGTGAGAAAGTAGCATTATCTTTTTACTTATCCAAAGTGGAAAGGAATGGAC TTTGAACTCAAACCTAGGTCTAGTTAACGACGAGGCCTGTGCTCTTAACTGATACATCAGA CCACCTGGTTGCATGCTGCTTCTGGGCAAGCGAACTAGTGCTGGATTGGCTAAATGTTCGT TTTTTGTTGTTCAATATGAAGTCCTTTTGGTCTTCAGATAACTAGATACAGGATAAACAGT

ATCTAAGGGTTGTTGTTTTATTGTTTTAAAGCATGGATCAATTACAGCTCTTTTGGGTTACA CTGGAAATTTCTAGCCAGAAATTTCATGACTAANAAAAAAAAAAAAAANAAAAAAANNN NCCαSTGGGGGGGGGNCCGGGNCCCAANTTCCCCNTNANNGNGGGGGGTTNAANNTSπ^NNN NMSπsπSlNNNNNNNNNNNNNNISπ^ NNNNNNNNNNNNNNNNNN MNNNN^

NNNNNNNTNNNNNNNNNTSINNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNTSf^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNOSINNNNNNNNNNNNC

GGNGNGGGGGNAGGANTCCACTNTTGNCTTNNNTTNTNTATCANTCCNNNNCTTCCΑSFTT

CATACN<_^TCTCTNTTNGACNTGANTNNNCTCTNNCNACTCCACNNANGGTNGNNGGTGA

NTNNANCNNTANNTAANNTAGAGANNNANCTGGGGNACTCNANCACNGNGGCNGACNCT CTANAAAOSΓNNCTGGAGCCACTCTTCCCNGCTCTCATNCC ΓNNNCAANNAGNTANNTTA

TTTNNTTANTCCTAACCATTCNTCTCTNNNNNNTGGGGATNNCTATTANAGNGNGTNACTC

(^TCAITSINTANCNNTCNTANANCTCGGGGNNCCACNNTNTANTTTAGGCNNTNCNGATAN

TOSINNATNGNNATNCTCCATTNCNAN NATAAAAGANNNANNTNGCGNTCTTTCNATANNNNNGNTANNTNNNTGNTGNNNATAGA NNATATNGAANNATNTTGTTNCGNATTTNNNACTTACTNNTTGTANNNNANGT^ CNATGTCNCCGANGTNTNNCTNNANNANGCANTGNNAGCNCGNTSINGNTNNAGTCNCNTT NTGACNANGANTCACGNGNNNNNTACGTGCTNNTTNNNNTNGNTATTNNNNGNGAGGNN ANNATANNGNOSπsπsπSfGTGATGNGTCTTTTGAGNATATTAGTGNNCATNTNNGAGCCGNGN AAGGTC(^TGNNTTNTNNTNTGNT<^GNN^

NANCGATNC(^TGNGANNNNTCGNGTANTACTNNTNGGGNTATTTGTNTCGTANNTGNCG ATNGGNCNAGTTANGGCTTCTATAGTGTCTNGTANTCNATATCTTGGNGGNCCCCNCTTTA TTANANGNCTNNAANNNGNAGNNNTNANNNTNTCACACNCCTANGANNNCACCCATNTC CTINNTATNNTANTANNCATNATCTAGTTNNNTAATCATA^ TGAGATGGTAA(^CCTTNNNNNCTC(^CCTTNATCNNCGANGNNATNNNTCTANNAGANN

CNTACGCNNTNCCTNCNCATNNANTTATTNNNANTAαSITNNCNCCGATNTAACACGACNT GNNGGANNNCGOSπsrANCGTAGGTAANAGTCNTANGNAGTAATTTNATNATGACTANNTG NACGGAAACTNNNTTACANTNCGTGAAACTATGGANGTTNNTATNANTGATNGNATTCGN AGGGGNCCTGTAGCGNTNNNAANAGNNGNNGNTTNNTANGNTGCNNGTAACGTNCNATN NCNCAGCGANNNCGCAGTTNNNCNGTTGAAGNTNTNTATGTATGTACCACGNCCGTAACN

ANGTNANATNNANGNACGNGCGTNTCNANCTAAATANACTNGNACGCANGTACNCTAAG AGTCGA(^TNNTCATCCTTGCTTACTCTTANNTCTCGNTTCTNCNCTNTCTNCGTAAATCA ATNTNACATAGANGTAANTCNNNCACAGNTAATAGNANCTACGGANATNTCCACNNTCGT NTCTCNCCATTAAANNGAGTGAATGANTGACNNTNTANTAACNTNTNACGNNAGNGTACN NNTαsrGNAGNCTNTTCGCATNNTGTNTGGTGTNNNNNACACαsrAATGAAATANACAANTC

ACCCGG

GGNGNGGGGGNAGGANTCCACTNTTGNCTTNNNTTNTNTATCANTC(-MS[NNCTTCCCNTT CATACNCNTCTCTNTTNGACNTGANTNNNCTCTNNCNACTCCACNNANGGTNGNNGGTGA

NTNNANCNNTANNTAANNTAGAGANNNANCTGGGGNACTCNANCACNGNGGCNGACNCT CTANAAACNNNCTGGAGCCACTCTTCCCNGCTCTCATNCCNTNNNCAANNAGNTANNTTA TTTNNTTANTCCTAACCATTCNTCTCTNNNNNNTGGGGATNNCTATTANAGNGNGTNACTC COTCATNNTANCNNTCNTANANCTCGGGGN^ TOSπ ATNGNNATNCTCCATTNC NTTN

NATAAAAGANNNANNTNGCGNTCTTTCNATANNNNNGNTANNT NSINTGNTGNNNATAGA NNATATNGAAN ATNTTGTTNCGNATTTNNNACTTACTNNTTGTAN^ CNATGTCNCCGANGTNTNNCTNNANNANGCANTGNNAGCNCGNNNGNTNNAGTCNCNTT NTGACNANGANTCACGNGNNN TACGTGCTNNTT NSΠWTNGNTATTNNNNGNGAGGNN ANNATANNGNCNNNNGTGATGNGTCTTTTGAGNATATTAGTGNNCATNTNNGAGCCGNGN

AAGGTCCNTGNNTTNTNNTNTGNTCNGNNTNAN^

NANCGATNCΑSFTGNGANNNNTCGNGTANTACTNNTNGGGNTATTTGTNTCGTANNTGNCG ATNGGNCNAGTTANGGCTTCTATAGTGTCTNGTANTCNATATCTTGGNGGNCCCCNCTTTA TTANANGNCTNNAANNNGNAGNNNTNANNNTNTCACACNCCTANGANNNCACCCATNTC CTTNNTATNNTANTANNCATNATCTAGTTNNNTAATCATANCISINCTATTTCTGGNT^

TGAGATGGTAA<^CCTTNN]SΠSINCTCC

CNTACGOSINTNCCTN(^CATNNANTTATTNNNANTACNTNNCNCCGATNTAACA GNNGGANNNCGCNNANCGTAGGTAANAGTCNTANGNAGTAATTTNATNATGACTANNTG NACGGAAACTNNNTTACANTNCGTGAAACTATGGANGTTNNTATNANTGATNGNATTCGN AGGGGNCCTGTAGCGNTNNNAANAGNNGNNGNTTNNTANGNTGCNNGTAACGTNCNATN

NCNCAGCGANNNCGCAGTTNNNCNGTTGAAGNTNTNTATGTATGTACCACGNCCGTAACN ANGTNANATNNANGNACGNGCGTNTCNANCTAAATANACTNGNACGCANGTACNCTAAG AGTCGACNTNNTCATCCTTGCTTACTCTTANNTCTCGNTTCTNCNCTNTCTNCGTAAATCA ATNTNACATAGANGTAANTCNNNCACAGNTAATAGNANCTACGGANATNTCCACNNTCGT NTCTCNCCATTAAANNGAGTGAATGANTGACNNTNTANTAACNTNTNACGNNAGNGTACN

NNTCNGNAGNCTNTTCGCATNNTGTNTGGTGTΪ ΠSINNNACACCNAATGAAATANACAANTC

ACCCGG

NNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGCGGGTTTGCCGCCGGGACACAGGTGTCGTGAAAACCACCGTTAAACCTAAGCCAAA ATGGGAAAGGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCAGGGAAG TCTACCACGACTGGCCATCTGATCTATAAATGTGGCGGGATCGACAAGAGAACAATTGAA AAGTTCGAGAAGGAGGCTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTGGGTCTTG GACAAACTTAAAGCTGAACGTGAGCGTGGTATCACCATTGATATNTCCNTGTGGAAATTT GANACCAGCANGTNNTATGTAACCTTNNTNGNTGCCCNAGGNCACANANNTTTCNTCAAA AACTNGATANΑSRGGCCCNTCCAAGNNNGNNNGNNTTGCCTNGATCGTGNTNGNTGGGGT GGGNAATTTGAAGCCGGTNTCTCCAANAACGGGCANACCCGTGAGCATGCCCTTTTGGCT TACCCCTTGGGNGNGAAACAACTAATTGTTGGCGTTAACAAAATGGATTCCACTGANCCN

CCCTATANCCANAANAAATNCAAANAANTTGTTANGGAAGTCANCCCCTTTTTTAAAAAA ATTGGGTTACAACCCCCGACACAGTAACANTTTGGGCCAATTTTTGGCTGGAANGGGGAA AACCTTGCTTAAAACCAAGGGTTAAATTTGCCCTNGGTTNAAGGGANTGGAAAAGNCCCC CGTAAGGGCCGGNAATTGCCCOSΓGGGGAAACCMNICCCTTGTTTGNAAACCTTTGGGAATT GGNNTTTTGGGCCNCCAAATTTTNCCRØAAATTC

TTCC(^GGGGNNGTTTTTTNAAAAAANGGGGGGGGATTNGGGACCCGGGCCCCTTTNGGG GGCNGGGG

TNNNNCAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGG

CTGCAGGGTTCGATCCATGCCCATCCGAAAGGATGATGAAGTTCAGGTTGTACGAGGGCA CTACAAAGGGCAGCAAATTGGCAAAGTAGTCCAGGTTTACAGGAAGAAATACGTCATCTA CATTGAACGAGTGCAGCGGGAGAAGGCTAATGGCACAACTGTCCACGTGGGCATTCACCC CAGCAAGGTGGTTATCACCAGACTAAAACTGGACAAAGACCGCAAAAAGATCCTCGAAC GTAAAGCCAAATCTCGCCAAGTAGGAAAGGAAAAGGGCAAATATAAGGAAGAAACAATT

GAGAAGATGCAAGAATAAAGTCATCTTGTCTACAGCTTTCATTAAAAACTGTTAAAATGA AAAAAAAAAAAAAAANNTGGGGGGGGGNCCNGGNCCCNANTTCNCCNTATAGGGAGTCG NNTNACAANNNNNNNNNNNNNNNNNNNNNNNNT^^ NNNNNNTSπslNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNTSf^ NNNNNNNINNNNNNNNN^ NNM TSπ ONfNNNNN^ NNNNNNNINNNNNNNNNN^ NNNNNNNNNNNNNNNNNNN^

NNNNNNNINNNNNNNNNNNNNNNNNN^ NNNNNNlSfNNNNNNNNNNNN

TNNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCGCAGTATTTGTCTTCCTGTGACTGACTTATTTCATTC ATCATGTCTTCAGTGTTGTTGCAAAGAGTAGGATTTCCTTTTTAAAGGCAGAATAATATTG CATTGTGTATACATTCCATATTCACTCATCTGCTAGTGCACATTTGGGTTGTTTCCATTTCT TGGCTGTGGTGAGTGTGGTGTGGGGAGCCGGCGGGAGGCACTCCACCCGTGGCAAAGGTC ATGAGGAAGGAGGCTCGACATATGCAAAGGCGGGATCGAGCCTCAGGAGTCCCCCTGGA

AATTTTCGAGCATCTACCCCCATAACCAGAGCCTGCCTATTTCACTACTTTGTGCTCTCACC TACACCTCTGACTTTACGGGGGGCTGTCCCCCACCACCTCTTTCAGAGAAGGAGTTAACTT AGAGCTCCAGTTAATAATAATTCCTGGGCATGACAGGAGTGTTCCAAACTTACCAACTCCT CTGAAGGTTCTCTAGCCTGCCTGACAGGCTTGTCCGGCCCCATGTGATTGCTCACAGCCTC CCAACCATGAAANGCACGAGATGCGTTAAACCTTNTAAAAACAGGTTCCNTTAAAAAAGT

TAANAAAACCCTTTAGTATAAGTATGGGGGGGCTGATTAAAAAATTGGATTGGGGGAAGG GTTTTTANTTTGTTGGGNCCAAGGGTTAACTGGGTAAATTTTCCAAATNCCCTGGCCNTTT CCCCCCTTTTNTGGAATTTTTTTNNAA GGTTNAACCCTTTNGGCCCAANAAAATTTTTTTTNTTTAAT^ TNCCCCTTTAANGAAAAGGGACNTTTTTTITGGGGGGGGGGGTTTT^^

TTNANCAANACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGGTTTTTTTTTTTTTTTT^ NNATNGTAANNAAACCCCCCHNAGGGGGGCCC(^AAAAANTTNNTTTTTS[NT^

CTTTTTNGGGNNNANGGGGGGCCCCCCCCTAATAANNCTNGGGTTGGNNNACCCNNNTTN GNNGAANGGGGNAAAAANNGCCCNGNANGGNCCCNCCAANCNAAANNGATTCNTNCCNT TNGGGGGNANNAAAANTTT^WATTTTANNGGNCCGGGGGCCCNGGNNNGNAANCNCNTT TNGNTTTTNGNNGGAANNNC(^GGNNNNNNGGGGGCCCCCCNGNANNGNNNNT^ NGNAAAAAN(^TNGGGGNNGNNANNGCNC<^TTANNNAGGNANTGGNGGGTNGTTTAAN AAATNCCANNNGNCNCCTTC(^AANAANCNNGGNNNGAAAAAGGNTTTTNGGCCANGGA AANCCNTNTTNGCCAAGGGGNANANCCTCCCOSITTGGNCANCTGGAACTTTTTTNCNAGG AANAAAAAGNAGGTTCCCGGGCCCTTTTTNTTTTAAAATNC^ TTTTT(^TTGTTGCCCCCCCAAAATTTNCCαsπsπS[GGGGNGGGGGCCANAAAAGGAA^

CCCTTTTTTTTGGGGAGAAANTTTTTTGAGGNAANTTTGNNA^

GGGNAAANGGGCCOSINTAATGGGNTTTGNGGGGCAATTNCCTTTANCCCCCTTTNAAAAA AAAAAAAACATTTGGGGGGGGGNAACNCσSTCTNCCCCTTNAANTNCCANNAAAAAAANA CCCCCCTTTTGGGGNGCCCCCAAAACCCTTNTGGGGGGGGGAGACCCCT

CANNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTTTTCATGCAGCAGGCCTTTCCTGTTGTCATTGATGTCCTTACCCCCCTTCTCTCCCT TCAGTGGTCCCCGTTATGGAGAGTAGAAGTCATAAAACTCAAATCCCTACAGGGACTAGA

AAGTTAAGGTAAATGGACAAAGTGAGATGGATGTGAGAGGAATGGGAGGAGAGAGGAA GTGCTGTGGCATATTGTCCCGTCTGAAAGGGGCACCTGCCACCTGCTTCCACGTGGGAATG CGGGACCCAATTTGACATATCGTCCAATTTCTTAAAAGAAGCCGAAAATCCAGAAATTTTT ATGAGCGGTTTGCTGATTTTTAAATATTGACTTTTAGTTGAGTTTTTAAA^ ATTTTGTGAATTGACCTACTTGCAGTTTTTGG

GTAAGTGATGCTTCTTCTAAATAACGCTCTTTCCTTCCTCCTGCCTCAAAACCTGGCAAAA TTAGGTTCTTTAAGATTCCAGGTTAGCCTTTCCTGACCCCAAGACAGGCAGTTCTCCTCGT GTTCTCCAAGCTCTAGCACTTACTACATTACATTGCAATGCTTTGNGTTTTATTCCCTGGCT TTGAGCAAAGACATTATTTTATTCTTCTTGCAAAATTATACACTTGGTAAGTTAAATATTTT TTGCCATATAATGGAATTAAACTCTTTANTTTTCATCTAATGGAGTCAAGNATCATAATNG

CTCTTCATTGAATTCNCTTTCTCCCACCATATTTTTAAAACCNAAAAAATATTTπ NGGAANNCNTANTTTAAAGNAAACCCCCCTTTTGANACTTNAATTTGGCATTGGCAAGGT TAAAAAANCCC

AAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGGAGATCTCTGCGAACAGTTCAACTCCATGGAGCCCAACAAACAA AAGAATGTGTCTGAAGAACTGGACAGAACCCCACCTGAGGTGTCGAANAAGCTTGAGGA CATCCGGACTCGTTATGCCTTCTGAGCTCTTTTCCTGTGGGGTTTATCANANACTTTATTTC CCTCACCACGTGACTGTGAATCTCTGTGACANAANAAGGGNGGTGATAATTAATACTTTG

TAATGTTAAAGCTCTTAGCTCTTCCCATCCACTCTTTCCTGGAGTGACAGGTTCCCCCTAAA ATTGGCACTGAGATTTGCTGCACTTCTCCGTGCCTGGTACATAATCCATTGCCCCCAGGTT NTGGTGTGGAATACAGTGTCCCTTTTCCCAAAGCTTTCTTGCATTGATATTTGGCGGCTATC CNGCCTACTTTNGTACACACCTTTAATTNTNANCTGGACCACCTGTACATACAGTTNTGAA TGATGCTGTCTGTGGGGGNNCTAACNNAGCNGCCGACCAGGTTNNTTATANCACAGNGTC

TGGAGNCCTGNCTGTATCCAAC⁽^AGCNATGAANACNTNCCTTTTGTNGNGAGGNGANNN NNNNNNNNNNNNNNNNNNNNNTTNNGGGGGGGGGGGGGGGGNCCCCN^ TTNNT NAGGGGGGGNNNNNTNN^^ NNNNNNNNNNNNNNNCNNNNNN^ NNNNNNNNNNNNNNNNOSENNNNNTNNN^

NNNNNNTWNNNNNNN^ NOSINNNNNNNNNNTSfNNNNNNNNNNN^

NNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCTCCCATCTGTCCAGTTAACATTTCCCTCTCTGTTTTCGAGAT AGCTCTCCAAGAGGCTGGGGTTCCTCAAATCTCATTTAGAACCGTGTGCTGAAAACCTGG ATTGGTGACTGCCATCCTANGCCGATGTGCTGGCCCAGGGGAAGGAAACTGAGCGAGTAG AAGTCCCTACCANAAAGGGTTGGGTTTGGAGAGGGGCATCCAGGGTACTGAAGTCCTANG TGCCAGGTATCTCCCCGCTCCTCTCANCTTGNGCAGAGGTGTTGACAGTATTATCTTCATTT

TCAGTCTCCTTCCAAGTTCTGTCCTAAGCTATTACCTTTGCAAGTTTCTGGCCCCCACCCTA TCAAGTGGGAATCCCTTCCTCTTCCACTTTATCTCCTTCATAATAACGTTGAATTCCCTCCT TTCTCCTGTTTGAGAAAGGGGGTCAAGAGAAGCAAGAGATAGCCTTGGTCTCTTAAGTCT CCAGAAAGCCCCTCCCCACCCCATCTTTTCTTATCAAAAAAAAATGATACGTATCAACCCC TTCTGTACTTATATGGAAAGGGTATGTGCTGCCACCTAAACGTCATTTCCCCAAAACAGGG GAACAAGAACACCTTTNTATCTTTTTGGCAAAACAATCTTNATNTCNTCCTGGCTACTGNN TTCCCCACTTTNTTTGGATTTTTGGCCCTATTTCTACACTNTCAAATTπ

GCCCCAAAAATTNNATGGGGGAACα GNAAAAATNTTAAAAAAAAAANAAAAAANACCT TCNNGGGGGGGGCCCCCGGGTNNCCCAATTTNCCCCCTTTTNAAGNNNGNGGNC

GGGGNNGNGNACNAAATNTTAATTNNATNTTNW^ TNTTTATTGTGGAGGNGGGNCNGACCTCTACNNNGGGGGNGNGNTGNTAGTTACCNAACA

TATTNTATCCATTAGGAGCTCTATANTNNTTNTNGNCNCATTTCTTNATANTGTNCANNNG AGGGN(^CNGTTANTNNNCC INNNNNCTNTTTTTNACTTATATNTTCCATAANT^ NANTTTNAGNGGNTTNTTATNNCGNTTAGCTCANAGTGCNCNTCTGNNAGNTCNTTNCNTT AAATGANGCCCNGTCANNTNTATTANAANATNTGNGTGCMSINNNCAAANCAGNANGNTG ANNTNGGNCGTNATTTTGATNNANTNNCTATGTGCGANTTACNNGANGCTGACNTNGAGN

ANNANNGGNCCANAGNNNATαsrCGGCCNANNACACANTTGACAGTANTGNNNTNNGNGT AAAISQSTAGATGANNNCGONTGAGNISITTGTNTTC^

ACNCGTANTNGAGNTTGACTGNNNGNGAGTANGGANANGNCANNNNNNCGATGATNNNG NNNNNrlNTNNGCAGGT∞^ GNNATAGOSfTNNNGTTNCNNTCCN^

NTGTANNNNANNNTGGAANNNNACGAGANACCGNNAGATATNNATNACCNTNNATNNCN ANANAGGTCCANCTANTNNCNTTCGNNGTNATCTNTCNTNNNCGNNNGNATCNCGAGGN ANNNCCAACTNCACNNACGNNNNNNCGGT<^WCATNNNCNTGNNCTATGTNCTACACNG NGTCTCCTCNCNTNTGTNNACCNTATAAGNTGTCCTACGNGTAANACTGANNNAACGTCN NACGTCCNNTATANTCCGGANCANNCNATACGTAANGTNCTAGNAGCGNCANNGTNGTG

ACTTCTNANTANCANATCNTGANTNNAGGTTANTACNTACNATNNNACNNCNGAGATTAN TNNCGTNNTNNCNNNNGNTGATTTNTAACGCANGACCNCCATCCACGCATGATCATANTA CGNTGGANCNANTNCGNNNTANTNTGNANACNNTCTTGTTCGTNNGNNNNTCNTCATCAN GNNCANANNTNCTACGTNGANTNGTCCACCTTAGCGANGOSINTTNTAANTNTANNNCAGA TCCGNCCTCACCACNGTANTGNCTNGNTNANNNTNATCGNCGCTCCCGCANNACTANCTA

CNNTAGGAATANNCACNTNNT1S[NNTNATNGNTCGCACGTAGNANANACNTNNNCANNNT AGNGCGGTAGTNAGNGGTCCGCNCTGTACGTNTATATCNCCNACNNNATGTCTGTGCGCA NCACGGNTTACGNCNACACGNTNGGNNGATGATAATNGATNGATCGCTCGACCGNNGGT NATGNI^NNNNTGCANNGAANNNCGNAGTCGTANGCTACANAANNTNTNNANNNATAATA AANAAANACAGGGNATGNNANTATNTATGATATGGGANGNGTNNTTCTGNTTGANATNG

NTNTNNACNGNTNTNTAATGGATGGANCACGANGATANGNNNTNNTNTCNTTATGGNTGT ANNNTATNCCATGTNCGCGNACNCNATGNGTAANGATGCNCANGCAACGAAGTNACNTN NTNAGGNNGACNTGNATGCGG

GGGGNNGNGNACNAAATNTTAATTNNATNTTIS^

TNTTTATTGTGGAGGNGGGNCNGACCTCTACNNNGGGGGNGNGNTGNTAGTTACCNAACA TATTNTATCCATTAGGAGCTCTATANTNNTTNTNGNCNCATTTCTTNATANTGTNCANNNG AGGGN⁽^CNGTTANTNNNCCNNNNT^ NANTTTNAGNGGNTTNTTATISINCGNTTAGC^^

AAATGANGCCCNGTCANNTNTATTANAANATNTGNGTGQWNNNCAAANCAGNANGNTG ANNTNGGNCGTNATTTTGATNNANTNNCTATGTGCGANTTACNNGANGCTGACNTNGAGN ANNANNGGNCCANAGNNNATCNCGGCCNANNACACANTTGACAGTANTGNNNTNNGNGT AAANNAGATGANNNCGOSΓTGAGNNTTGTNTTC CNTNCGNAANNCNI^CNNTCGANNAT ACNCGTANTNGAGNTTGACTGNNNGNGAGTANGGANANGNCANNNNNNCGATGATNNNG

NNNNNNNTNNGCAGGTCCGAANNNCNANAATANNCNNGAGTNNNNNTAC^GAGNNNNN GNNATAGΑSFTNNNGTTNCNNTCCNGTTANNNATNTTN^INCNCGNNANGNGNTANNCGCG NTGTANN WANNNTGGAANNNNACGAGANACCGNNAGATATNNATNACCNTNNATNNCN ANANAGGTCCANCTANTNNCNTTCGNNGTNATCTNTCNTNNNCGNNNGNATCNCGAGGN ANNNCCAACTNCAOSΠSRACGNNNNNNCGGTCNNCATNTSINCNTGNNCTATGTNCTA

NGTCTCCTCNCNTNTGTNNACCNTATAAGNTGTCCTACGNGTAANACTGANNNAACGTCN NACGTCCNNTATANTCCGGANCANNCNATACGTAANGTNCTAGNAGCGNCANNGTNGTG ACTTCTNANTANCANATCNTGANTNNAGGTTANTACNTACNATNNNACNNCNGAGATTAN TNNCGTNNTT^WASINNNGNTGATTTNTAACGCANGACCASRCCATCCACGCATGATCATANTA CGNTGGAN(^ANTNCGNNNTANTNTGNANAOSINTCTTGTTCGTNNGNNNNTCN GNNCANANNTNCTACGTNGANTNGTCCACCTTAGCGANGOSINTTNTAANTNTANNNCAGA TCCGNCCTCACCACNGTANTGNCTNGNTNANNNTNATCGNCGCTCCCGCANNACTANCTA OSTNTAGGAATANNCA(^TNNTNNN^ AGNGCGGTAGTNAGNGGTCCGCNCTGTACGTNTATATCNCCNACNNNATGTCTGTGCGCA

NCACGGNTTACGNCNACACGNTNGGNNGATGATAATNGATNGATCGCTCGACCGNNGGT NATGNNNNNNTGCANNGAANNNCGNAGTCGTANGCTACANAANNTNTNNANNNATAATA AANAAANACAGGGNATGNNANTATNTATGATATGGGANGNGTNNTTCTGNTTGANATNG NTNTNNACNGNTNTNTAATGGATGGANCACGANGATANGNNNTNNTNTCNTTATGGNTGT ANNNTATNCCATGTNCGCGNACNCNATGNGTAANGATGCNCANGCAACGAAGTNACNTN

NTNAGGNNGACNTGNATGCGG

TTNANAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCNANCNNNNAGANNNNANANNTGACCNNGGATCANACC

NATNANTTGAAGGNNGNNCTTCCAGCTGNCNTACCGACCGGGGGANGNATNGATCCTGTA CAGATANNGTGGNCATGAGATTAGGGCCCTGTTCCAANCCTNNCCAAATGTTACGGTNNN CANTGNCTTGCGNAACCCCCCCATNNACGAANNNNACGANNAGGTTACTNANCNTTGGG NNCTTGCTN<^CANGNTNNTGACTNNGNGNCATAANATGGANCTNGGCC JNTACAATNN NTGNNCCANNCGTCTNAGCGTGTNCNTNAA(^ANANGAACGGNCNTTNTACTGGGTTGCT

TATTGGCCGGGNCCTNGTNCNTTACANTGGGATGCNATCNTGACAGNGGATCAATTANAT ATTCCCNTAGCCTTGGAATNAGGACCTTAATTGCCTTGNNCAANTNAAAACAAGCCNCCC CCNTANGGGNGGGNAACCGGCTTATGGATTCCGGCCCCATNAACCGGAGGGNGGCCCTTT CTTNTNGGAATTTTTCCGGGGCTTTNGGCCGTTTTTCNTTπ AANNGGGCC(^CCCANTTCCCTTTTTAAANNAGAAAAATNTNCGGGGGACCNAAANNGG

TAAAAAAAAANCCCTTGGGTTCCCCTGTTTNTTGGGGCGGNCNNAAACANTTTGGGTNNT

TGACCCCGGGAACCNTTTNTTTGGAANCTNGGAC^TTAAATGGGTTTTTTGGGCCCCCCCC CNTTATGGGTTANNCCTNGGGNCCNTTTAAANGNNANGGGGGCCCCNGGGCCCTAAANTT TTTTTTTTTTTTTNCCCCCCCCTTTT^

TTGANAAAACTGGACTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTG

CAGGGATAGNNTNATGCCNATNTGANGGNAATATTAAACAANGCACGCCCNAGGGCACT ANAAAGGNCATCATATTGTCAANTTAATNCAGGTTTACAGGACCAANTACGNCATCTCAT

TGAACCGAGTCAGCCTGANAANNNTATTGTCACNCCTNTCCNGNCGTACATNNANNCCAT

NNCNNCGNNNATNACNATACTTATNATTGNCGNTNATANCCGANNTANCATCGTTNGTNT

AGCNAGNNNCTCGTCNTTTATNAAAGNATTCAGGGCAAATNTNAGGAAGACTCACTTGAG

AAGATNCNATAATAAAGTTATCTTGTNTNCATNTTTTCATTANNAACTNTTANAATGATAA NNATTTAANTTTNTGGGGGGGGNTCCCTTTTTCCTT^

NCNNNCTACTTCCTTTNTlSfN^

NCTNTAACATTTANCCTCTNTACNTTTTTGN^

TNNOTTTTNTTTNTN^

NCTNISINANCAATTNTNTTTTK^^ NTOSINTTCNTTNNATANANTTTTNNTTTTCNTT^

TANTTTTCNTTANNAATTTTCTCTCNTCTTCCTCTTGTTTTT^

TTTTATTATTTNTTTCTTCTC ^

TNCTTCTTTTACTNTTTCTAATTTC

TTCGNG(^TCCTTATCACNTTNTTCTGTANNTNCANCTTCCTCTTCCT

NNCAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGNTNNNANGCCTACAAACCNTCCAACCANNCGCACTGNTACGGNAAAA G(^GCTTNATCGTCATACGCCTTTNTTACCAGCATAATGNCCACATTNATATTTATCCACT TCGGGNCANGAACTAATTANTTCANACTGGNCACTGGACTAAACCATCCCAANTCTTAAA

TTAATCCCCTTAAGCNTTAAAAAAGANCTATTTTCTTCATNAATATTTAATCCCAGTAGCA CTAATCCGGTNCATGGATCTAATATAGAAATGTTAATTTGNATATATATACCTCAGANCCC CATATTAANCAATTCTTTCAAATATCTACTTCCTAATCCTTAATTCTATGCCTAATCCCTGG AACCCGGAAANCACCCTTTTTCAGGCTTTCATTGGCTGGAAAAGNGGTCGGAAATCTTAT ATTTTCTCCTATCGGAAGGAGGATNCGGGNCGAAGNGAAGCCAACCCCAGGCAGCCCTTC CAGGCAATCTTATATTACCGNATTNGGCGACTTGGGTTTATTTTAAGCAATAAGCANGGTT CCTAACCAAATCTTCATTACCTGGANACCTTCCACAGGATCTTTATTCTTAAACCCAACGA ACTTCAACCTTACCCTTGGATTGGACTAACANTTAGCTGCCANCCGGAAAATCCCGCCCAA TTTGGGCCTCCACCCGNGAACTTTCCCTTI GGCAATAANAAGGGCCCAACTTTCCCGNTT

TAAGANNTACTNCATTTCAAGCCCCAAATAANGGGGAGCCAGGGATTNTTTCCCCACCTA AAACCGGGTTNTTTTCCCCCTCACCGGNAAACCCATTTAANTTCCCTTCCCAACCTNTTTA CCNTTTTGGCTTTNGGGNGCCCNTTTCCCCCCCTTTTTTTTCCCGGGANNT^ NCCCCCCCAATGGGGCCTTTTAAAAAAAAAATTTGGGNTTTTTCCCAAAAANANANAAAA AA

TTNANCAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGAATTCGGCACGAGGCACCAGCCCAGGCTTGGACAATGGGNGGGGACATGTTC AACGCCAGGTTCATTCGAAACTTGCATGAACGTCGCAGCACCAGGCCTTGGTGACCGCAG

CCCCCTCTCACACCTTCAAAATCATTATTATTTCTATCTCACACAGGACTTAGTCAAAGCTT

GCCCTCGCCGTGTATGTATTCATTCATTCATTTATTCATTCTACAGGCTTTTTTTT^

CAGGGCCAAGNCATTTGNATCTTATTTTTAACCANAGCAATAAAGTNTTTTT^

AAAAAAAAAAAAAAAANNNNGGGGGGGGGNCCNGGACCCNATTTCCCCTTNNNGGGNG NNGATNAACNNNCGGGGGGGGCCNGGNCCCATNNNCCCTATAANANGNNANNNAAAAN

NNNNNNNNTNNTNNGNAN^

NNTNATTNNNNNNGNNGNNTATlSfNCNNTNNCNTTNTTNANN^

NNANNANTNNNANNNNNCNGNNCCNNTNNNNNNNNNANNN^

NNNNNNNNNNNNNNNNGGN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ MNfNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

AAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGATATCAAGCTTATCGATACCGTCGACCTCGAGGGGGGGCCCGGTACCCAAT

TCGCCCTATAGTGAGTCGTATTACANNNNNNNNNNNNNNΠWNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNT^NNNNNNNN^

NNNNNNNNNNNNNNNNT^NNN^

TNNNNNNNTNNNNNNNNNN^^ NNNNNISINNNNNNNTNNNNNNNNNNN^

TNNNNNNNNNT πWNNNNNNNNNNNN^

NNNNNlSπSINNNTNNNTSINNNNNNNNNNN^

NNNTNNNNNNNNNNNTTTNNNNNNNNNN^

NNNNNNNNNNNNTNNNNNNNNTNNNNN^

NNNNTNNNNNNNTNN^

NNNCNNNNNNNNNISINTNNNNT^^

GCCTATAGNGAGTNGNATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTTCGGTATCGAGGCNCNNCGNTANCNCAGGCCTCTCGGNTTNGCCGGTCCNCC TTNNCCGCCNATNGAGACCGNAANCANNTCGCCATGGATGATGATATTGCTGCGCTCGTG GTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCTCCCCGGGCC GTCTTCCCGTCCATCGTGGGGCGCCCCCGGCACCAGGGCGTAATGGTGGNCATGGGCCAN AAGGACTCGNACGTGGGGGATGAGGCTCANAGCAAGAGAGGCATCCTGACCCTCAAAGT

ACCCCATTTGAGCACNGGTATCGTCCACCAACTGNGACNACATGGANAATATCTGGCACC ACACCTTNTACAACGAGCTCCGTGTGGCCCCTGANGAGCACCCCGTGCTGCTGACCGANG CCCCNCTTGAACCCCCAAAGGCCAACCGTNAGAAAGATGACCCCANATTNTNTTTCTANA CCTTTNAAACACCNCCTGNCATGGTACTTGGGTCATTCCAANGCTGTGCTGTCCCTTGNAT GNNCTCTGGCCCGCACCAACTCNNCATTTNNGATGNAOSπsrCNGGTGACCNGGGTTNAACC ACACNGNTGCTCCATCTTATNAGGGGGTNCT<_^C^

GAACNTNGGCTTGGCCGGGGAACNGNCTGGANTTACCTTANTGNAANCACTCTTCNCGGG NNCGNGGNNTATTNISINCTTT^^ NNTTTANNTTAGAAAATTTTTNTCTN^

OWAGTNNGCGATTNANANTTTCTCCTTTGNNANAGNAA(^TCNAAACTN

NT(_ GAGTNTTANNCTANAGANNTIS[NAG

CCAGTTTCCTTTTCTTNTGNAATGTAATANNTGANCC

NCAANATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGCCTGGGCATTCTGCTGTACACCATGCTGGCGGGATACACTCCATTTGCCAATGGAC CCAGTGACACACCAGAGGAAATCCTGACCCGGATCGGCAGTGGCAAGTTTACTCTCAGTG GGGGAAACTGGAACACAGTTTCAGACACAGCCAAGGACCTGGTGTCCAAGATGCTGCACG TGGACCCCCACCAGCGCCTNACAGCCAAGCAGGTCCTGCAGCACCCGTGGATCACCCANA

AAGACAAGCTTCCGCAGAGCCAGCTGTCACATCAGGACCTGCAGCTTGNGAAGGGAGCCA TGGCAGCTACCTACTNANCACTNAACANCTNCAAGCCCACCCCTNANCTGAAGCCCATCG AGTCGTCTATNCTGGCCCANCGGCGGGTGAGGAANCTGCCGTCCACCACCCTGTGAGGGG CCTGAGCATTCAAGCCGCANGGCGGTGCTAGCTGGATGGAGGCAGCGTGCTTCCCANAAN AAGCAGGCCTGAATCCCAGGGCCAGAGGGAGCGGAGCCCCGAGGGGCCCAAGAAAGCAG

CCCAGCCCAAAATCACCCCANGGAGGGNGNTGAGAANTGCCCTTCTCCTTNCCCCAGGAA CNGACTGTTCTCGGCTCANGCTCTGGGTGGGNTTGAAATCGAATTCACTGTACAAAACTCT

GAATNCATTTTTGGCCTTTTTTGGGGAAAAACAAANTTATCCCCNTNGGAAACCCCCCAAG GAAGGGGGGCTNGAATTCACTTCAAANGGGCGCCTCCTTGTGGGCTNGAAAACCCCCTTT

AAANACAAACTTTNANGAATTTNCCCCCCAGGGGGGAANCCCCCCCAAATTGGGGTGTTT TTTATNCCCNNCC

GGNNCGTGNNNNGTNTTTTNTTTTTTTTTNTNT^

ATTNNANNTNTTAANGCTNTNNCTNGGNGNANTGANNTGNATTNAAACANTTNAAACCAN TGGACTNCACGCGCTGGCGGCCGCTCTANACTAGTGGATCCCCCGGCCTTGCANGGNAAT TCCNGCACGAGGCCCNACTCNGCCCACCGGTGGCCCANAAGAAACTTGGNNTATTCANCN AATNAACCCTNTNTGANNAANTACGGCCCNGGTATNGGGTACTNNCNAAGAAGCNTTGAC CCNGNCTGGANTTTCCANTTTTCNGAGGNATGGGCGGGCANAGNGGNCNCGCNNCCCTGN

CCGAATGGGGCCNNTCCNACCTGNCTTTTTNCTTGNGCCCNGNAAGGNCCAACCNANAGG CNTTNCANAAANCTTTANANNTTNCAATTGGNNAGAACNTTTCNCNGTNNCTGCNTTGGG CCNTACTNAANNNNGTAACTCCNATANAAANGCTCCTTGTNTTTCTTTNATAGGCTCNNGN ACGNTAGANNTNCNTGAATNNCNTGNNCCCCCAGGGGNCANTNNTCCCTGTTTCTCCNTN ACANNNGGNNTNCNCCTNTCGAATGNGCTGGTNCNNNANTTATCACCNCGAAACAANCTG

CGGCGGCNCCCGAACAACNNTTGTACCAGTTACATNTAAAATTAACTAAATANAAAACTT CTCCC^CCTTTNTCCCANANAANTNCNTANNTTTTNGTNCCCCCCNNNGNANANCACTCCN GNANNαsrCCCNAGAATNCAOSfNCAANANTTTCCNGATTTTNTAACTAATGNNGGNN^ CNNNCAGGTTNTNANCTCTTNNNANAAAAGTNNTNNTTNTNNCC(^ GTNTNNTCTTTCCTCCNNCTAATCTNCATATAATTNNTCCCNTTNTTTTT^

CACTCANG⁽^TTANATAACNTCCACCTACTTNNNTCTANTACCCCNCTNTCNACTTCTNAC TCACNCACANGNTNGGTNTNTGACGTGGATCTTCf-^TCTCNCHNAGNACGTNCTTNTCGTN NNAGAAANATNAATNNTCANCGNCNAACTACTTGNNCNNCGNTTCNTAGTANCTNNTCCT ACGACTNNNGGNCNTAGTATTCNNTNNTATGTCGTATNTCCCACCTCNNNANTATGCNTN GCCNTTGAANCAACNCTNTCTCAATNTNGGNANGGNNTNGTTNO^TNTCCNTTNTNNTC

ANGNAATNACTCTANGANAGNNGTATTNCCNNTATCNNNTCTTCTCGNTACNGNNGTTCG GTACGNTNNNANNCTNCACTCGNNANNATGTCGTACGTCTGATGCANNCNNNGCNCGGTA NCATCTNCTTATNTNCNGTT<^CANGAT(^ANTANTGATTNTCGTATANGNTCNCCNACTN NCANGNTNTCTCNTATGAATCNCTTTCTCTATNTATGCTNCGTNCCNAAGANGTNNGCATG TGTNCG

ATTTTNANNTCTTAANGαsrTNNCTNGGNGCGNTTGNTATGGATTCAANCTNTTNAAACCA NTGGACTNCACCGCGTTGGCGGCCGCTCTANACTAGTGGATCCCCCGGCCTGCNNGGNAA TACCTGNACGAGGCCCNNCTCAGCCCANCGGTGGCCCANAAGAAACTTGGNNTATTCANC NAATAANCCαSfTATGGNNNAATTAGNCCCOSlNNTNGGTACTNN(^AAGAAN(^TTΗACCC NGNNGCNNTTTCCANTNTTCNNAGGAATGGGCNGGCCNAGAGGNNNCGCANCNCTTGNC CGAATGGGGCCHNTCCNACTGNCTTTTTNCTTNGCCCNNNAAGGNCAACNANNGGCTTN

ANAACATTNNANNTN(^ATGGNAGAACCNTGOSlNGN(^GCNNTNGGCCNTACNAA<-^ GNAACCNNAANAAANGCTCCTGTNTTGCTTTTATAGGCTNNATOSINTAATTTNCANAATN NαsπSTGNCCCCAGGGGGNCNNTNNTCCCTGTTTCTCCNTAACANNNGNNTACNCCTNTCGA ATGNGCTGNTNCCGNANTTATCACCNCGAAACACCTNNNCGNCCCTCGAACANCNNTTGT ANGCOSINTTACNTNTAANATTNACTAAATANAANACTTCTCCCTCCTTTNTCCCANACNAT

TNCNTNNimTTGGTNCCCCCαWTT^^ NNAANNNTTCTCCNGATTTTNTAACTAATGN^

TTNNANAAANTCCNTNCTTNTNNCHNNNTNCCCAANTGGNNTNTNCNTCTTNC AATCTACCATNTNATTNCTCCC(^TNNTCTTNNTNTGNTNNNTNCACTCANCNNANATA^ NTCCACCTAANNTACNTCTANTACCCCNCTGTCNACNTTCNCACTCACN CACAAGTAGTTN

TNNGACNTGTATCTTCCCTCT(^CNNAGNACGNNCTTNTCGTNGAGAAAAANNATNNTCA NCGNCNAACTACTNNGTCNNCGNTCTGTACGTAANCTCNTCCTACGACTNNNGGNCNTAG TATTCNNTCNANGTCGTATNTCCCACCTCNTNATTATGCNTNGCNGNTNCANTANCNCTNT CTNANTNNNNNGATGGNNTNGTTNCTNTNTCCATTNTNNNTNNGN^ GNTGTATTNCCTNTATCNNCTCTTCTCGCTACNGNGGTTCGTNCNNTNNGNTCTNCANTCG

NNANNATGTCGTACGTCTNATGCANNCNTNGCNGGNTANCATCTNCTTATNTANNNTNNC ATGATCNATNTTTTNATTNTCGTATNNGCTCNCCNACACGCANGNTNTCTCCTATGAATCN CTTTCTGATNTATGCTNCGTNCCNAAGTAGATNCNATGTCNCGG

TTNANNAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGNNAGCGTCAAGATNTGTNACTTCNNCNNGGATCANN CCGNANNGTTCAAGGAGGNCTTCCTNCTGNTTNACCGAACGGGGNATGNCATNATCCTGT NCAGNCNGNGTGGGGATGNGANNNGGNCCCTGGGCCATANTTCCACNANNNCCNNGGTG NTCNAAGTNTTGGGGAACCCNAAAAGTANTGAACATTANCNNNAANNGACCTGAATTTTG

GOSΓNTTTCCAACCC^TCTTGTAAATTNGNGCNANAACTAGGNACAANGCCNCTNNCANGN CTNTGGGΑSRATGGOSIN<^GGTGNTNNG(^AAGGAAGGAACCGGCCTNACNNNGGANNNT AAAATCCGCTCGGTGNCCGNCCNNNNGGTTANNACATTACCNNTGGACAACTTAAAGNTC CCNNGTNGCTTGGGCCTTAAGGCCTTTTANTGNTNGAANAANTANTAAAAACCTNGTCCG NTGGGGCC(^AATNG(^TNANGANTTTTCCAAATGNGCCTNGACACCNTGCCCTTTCTTTG GGGGAAAATTNGTTTTNTGCCCCGA(^CTTTTNAGNTTTNTTTG CCAAATTTNTTTTTTTTTGGANGAAGNOT TNGTNT INTTTGTTTTTTAAAAA^ GGNCCCCNCNTNNNNCM Π^JNNN JNNNATTI ^ NGNCCCTNNNNNOSlNCαNrT^

NTTNGGGGNNNNANANNNNNNTNGGGGGNNN^

CNNTTTNNNNTSINAANTNNNTTT^^

NAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTGCA

GGGAGAGTCTGAGGCCAACGTGAGGGAAATCTTCGACAAGGCACGCCAAGCTGCCCCCTG TGTACTGTTCTTTGATGAGCTGGATTCGATTGCCAAGGCCCGTGGTGGCAACATTGGAGAT GGTGGTGGGGCTGCCGACCGAGTCATCAACCAGATCCTGACAGAAATGGATGGCATGTCC ACAAAGAAAAATGTATTTATCATTGGCGCTACTAACCGACCTGACATCATTGATCCTGCCA TCCTGCGACCTGGCCGCCTTGATCAGCTCATCTATATCCCGCTTCCCGATGAGAAGTCCCG

TGTTGCCATTCTCAAGGCCAACCTGCGCAAGTCCCCAGTTGCCAAGGATGTGGATTTAGAG TTCCTGGCTAAAATGACTAATGGCTTCTCTGGAGCTGACTTGACCGAGATTTGCCAACGTG CTTGCAAGTTGGCCATTCGTGAATCGATCGAGAGTGAAATTAGGCGAGAACGGGAGCGGC AAACCAACCCGTCAGCAATGGAAAGTAGAAGANGATGATCCAGTGCCTGAGATCCGCCG AGATCACTTTGANGAAGCTATGCCCTTTGCCCCGCCGTTCTGTCAGTGATAATGACATCCG

GAAAGTATGAAATGGTTTGCTCANACCCTTCAACAAANTCNANGCTTTTGGCAACNTTCA NAATTCCCTTTAAGGAAACCANGGGNGGAGCTGGNCCCCAGTCANGGCAATGGCGGNGG CACCAGGTNGCAATGTGTTCCCCNGAAAAATAATGGATGATGANCCTGTNTGGNTTAAAN GGGGGGGGGNCNACCAAGCAANGAACCTGGCCTGGGTTGGAC(^TTTTTCCCTTGNNGGG GGGGGGCCCCCCCCCCAGGAAGGGAACCCGGCCCTNNCT

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGAATTCGGCACGAGGCTNTGAAGAGGTTGGGAAGTGACCACTTGGATGTCTGGGCCCT GCCAAGGGGACAGGGAGGGTCAGAGGGAGGCCAGCTGCTTCCTGCCCCCACCCTTTCCCC AGGCCCACTGTGCTGCTTTTGTGCCAAGATTAAGGTTAGCCAGTCCCTTCCCGTCTTGTTCT GTGTGCTTCCGCCTACCCCTCATCACCGCCATGCCCCTGCCCCACACCTCCCCAAAGAATT GAAATGTCAGCTCAGGATATGGGGCCAATTTATGTGAATCCAGCATGTCCCTGTGTCGCCC

TAGTGTCCCTTCAACCCGGGCCAGCCAGAGCCCCCCTTGTCGCAAGGCCTCGTCCTGTCGC CAACTTCTCGAGCACAATCGGGCTTCTCCCATCTCCAGGTGTTCTGCCGCTCTCAACCAGA GGTGCCTCTTCCAACTGGGGCGGGAGTCAAAACCTGCCCCCTCTGTGGGAGGGACGTGGA GCCCCCTCAGCCCTTCACTGAGTTCTTTGGAATTTGCTCTCAAGTGCCTTAANCAAAAGGA AAACCTTTGCTTGGTGTATGGNGGAAGGTCCCTTGCCTTAAAACCTTCTTCCCCGGCTTTG

TNCTTCCCCAAGNGCCTTTCCNTTGGCCTTGCTGGAAACTTGGGGGTTTTCNCTTGTTTCCC CAANTCCCCACAAACACTTGGCAAAAAAATTTTTTTATTTTNNTGNCCAATNGGGGNGGG GGGGTCAAACCCCTTAAACCCTTNTTGGGGGCCCTNGGGCCCTTGTTCCTTTNNTNTTTGG GGGCCCGCAATTTTTTTTTTTGGGGGGGGGGGGNGGGGNAAAAAAAAGGGCCGGNNAAA ACTTTTTNCCCAAACCCTTNTNANNTNAAANGGGGGGNNTTTTTTCNNCCCCCCNCAANA

TTTGGAANACNCATCTGGAGCTCCNCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCC CCGGGCTGCAGGTGCAAGTCTTTTAATAGATGTCATANCAGTGTTTNNAGAACTCACTGAT

NNGGATGσsrAAACACANAAGGTNNTCCCCNNNNNATTNCATAAANTATTCTTTNTNTGTC NNNCCGACNNCNNNCTCACACCNTNCAGNATANACTTTTTTCTGTNTATCTACACNCNNN GTNCTTATCTTTCAAATTNAAGTNATTANCTATTATNNNNACCCCNTTCNGTGACCTNANN TGTNTTTCGACAACNCOSrCNCCNTTCNTNTCANTNCACCACCATNTTANTCCATTCTTTNT GCNTGNCATTATNCCNCNNANCCTCTNTGGTTNCTCNTTTANACTCCNNTNTTCNTNNNCN

TTCNTN(^ATGTTNTCNNNNTCTNNTNNCTANNTTTCCNNNTNTGOS[CANTCT^ TTTTATTTTACGTAATNNTSπSI^

ACTCANNTNCNTNTNTTAACNGCNTNCTNNCTGNNNCCTCANCTNNGCTATATTTCTAT^ NACATTCNNCTANANTNNNATATCCCTAATT(^ACNCTNNNTCAAANTCNAGCNNCACCN CTCCKNNTTCANACCTTTTσsπSTANTTTNCNCNCCAANNNTNANCTNTNTCTCACCN^

TNN(^CACTAOSfTNTCCCNCTTTN(^TTACACCANTTAGANNACTCTNTTTNCAT^^ TTANNACNTTCTATCTTCTCTATANANNT^

NCAANANTATTTATNANGAGATNAATTNTCGTGCTAACNCTCACrøvfTCTTTATAATCTTAN TCNACCTTNTTCNTNNNTATCNTATNNTNTTCTCTTTCGCTCTCNTTNCTCNTCCNTAGNTT ATTTTCTCTCTTCTTNNTCAANATCNGNACNGNNTNCATTAATATTCNATTCANTACCATC

CTACTTGTNCCNCNTAGTNTTNCNCCNAAGTCNTCATATNTNANAATGAATANTGTGTNAT TTNGTATCACTCTTTAACTNTAGCCCG

NAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGATTTGAACCACTAGCCTTTGAAATAAAAGTCAGCCCCGTTATTAACAGTGCAGATACT GAGTCCACTTGGATTTCTTGCAGCTTTCTTTGCACTGCTTTAGGCAAAAAGTGTTCATCTGG TTTTTTTCATTTGACACCCCAGTTTGCTGCAGTGACAGAACTTAATGCCTAATCTGTAGAGT TCATATATATATATATAAAATATATATACCCACACAAACACATATATATATGAAGTTTAAT GAACTGTCCAAGTGAAACATCCTAACTGTCCTTGTGATTAAGGAGCCAGTTTTGCAGGCA

GCCAGCGCGGTGTTTTTCTGTTGGTCTCCCAGCACATGCCCATTCCTTTGCCCGCCCATTCC TGCTACACTCGATGGCAGCTGGTGACACCACTGTGAAGGTTTCTGCGGTCCTGTCTTGAGT GTGGCAGGCTGGAGGTGTACTGCCAGAGGTGAGCTGGGGCGTGTTCTGTTCCCCACACAT TTCTAAACTGCTACAGGCAGTGTACTGGCTACCACCTCAAGTCCAGACACAAGTCTAAAG CTGAATTTTGTGTCAGTAACCTTAACCCACCGAAACAAATCTTGAGTAGCTCGTATCCTGC

TCTTANGAATTCTGNTGTCATTTAAAAGTAATGTTCAACTTTCTTTTCTTTTπ CCTAAGCACTGTTTACAGGTGTATGCTAAAGCCTGAAAATTTTGTCTGGNGCTGNGGNGTA TGNANCATTGGCCAATTTTTATATTTAATTGGCANNCAAAAAAGAAACCTTAAAGANTTT NTGAAAAAATGAAGGAAGCCNTGGGCTTTGGCTCCCTAAATCTGGGNGGGGTGCCTTGGN GGGAAAAAAGGGAAATTGGGGGTCTCTTTNAAAAAGGAAGCCTTTTTGGGGGGNGGGGC ACCCCAGGCTTTNNCCTGGGGNNNCCTGNTNGGG

GCCTATNNGGAGCNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCCGCGTTCGGACCTCGCTGCTTCAGCCTCCGGGTCCCTTTCCA TCTTΓCCACCCTGCGACTAGCAGCANANAAAAACTAATTCCATAATATTTTTTTGCCCCGT ATACACTTTGAGGCGAGCAAAAAGATTANAATAAATTTTAACAATGAGGGAAATCGNGCA CATCCAGGCCGGNCAGGGNGGCAATCAAATCGGTGCCAAGTTCTGGGAGGAGATCANGA GATGAACATGGTATNNACCCCNCCGGCNCCTATNNTGGGGACAGCGACCTACAANNGGA

CCGNATCTCCGTGTACTACAATGAACCCACNGGNGGCAAATATGNCCCTCGTGCTATGNT GGGGGATCTAGAACCCNGAAC(^TGGACTCTGTTCGNTCAGGTTNTTNTGGNNAGATCTN CACANCANACNTCTTTNTTTTTGGTCAGGGNGGGGCANGCAACNGGNGNGCGNGCGGGCT ATTTATAANGAAGNAGCCCCTGGTTGANTGACGTCNCTNGATGGNTGTNGNANGGANGGN GNCANGATAGNNTTTGNCTGCCTGGCTTTNCTTTCAACCCACCNNCTTNGGTGGGGGGGC

CTGCCTCGGAAANGGGAACCTTNCTCTTTCTNATNAAACCCGANAAANNGATTCTNNTCC CGGAANTGNAAAAACCTTCNCNNNGGNGGNGNCCCCCCCNAAAANATTNNANNACTNNG NNGNNTGNGNCCTTAAANNCCNCOSRCCCTTTTTTNTTTATTATTGGNNGGGGGNANANN^ TTNNANAATATCCTTTTTTNT^^ CCNTTNAAGGTNGGCCCCCCCACCCTNTTGGGNGNTTTGGNCCCCNTNTNTTNNCCCCNCA

TGGNNNGGNGNNCCCCTNTTTCCTNCCTTTTTTCTTGGGNGNNANNANTTNGTNCCCCCCC

GCCCTATANGGAGNTGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGANTNGGNCTCGAAGATNTNAAGCCATGCCTTNTCCTGTACNACCANATNNTTATA

TGNTTGANCTTOSπSINCTCCNGNTTNANNNAGAGNANAAAGATGNAAAGGATGGCNNGGN GOSINTGNCNGGNGNαSlNNGNGCNAATNTNAACTTAAACCNAATNAATTATGGGGGNGGT AAATACAGACATTTTAACCCAAGCCACNANNNTNNTANNNGGNACNCAGCTTTTACGGNC NCNTGCTCNCCCANNAATNG(^CCGNTNTGCTTNTGCCGNNNNCNCCTCCANCCATTGNC TTGGαsTNTNCATNNGCGGAACNCNATGAπ

GNTGGCTNGGANTTTCTACTGTTNTNTTCNNAANTNANATNNACNACNTCAGNCTCTGCG GGTAATTCTATNTNAGGGGNNNTGGCTCGNCNCANAGGCACACCTCCTAANNTGGNGCNG NGCAAAACCCCACGGGGGNAANNTTTCACTGNNCATCNNNTGGNTNNTGTAATGNNTTCN NCCCNGGGGGNGTTTATTGAGCACNCCNNGGNGANNANNNTTNCNGATATTCTCCCCCCC NGGTNAGNCNNTGNGCGAACCCHNAAATNTTTTNCCTANAANGCCNNTNNTTCGATACTA

AAAAAAANAATGGGGGNNGNNNTTTNATATATGCQWTTNACCCCTC^CATATNNNN^ CCNTNTTTAANNATAATNGGCCTCNTTTTAT^ AGGGAANNTTTNGAAAAAATTTTNNCAAAAAAAATTGNNrc^ CCCCCπsrCCNNCTTTTNTCANATNTNGTNATAANCNACCTTCCTTTTANAGNCTTGNTTCGC CCCCCAAANATTTCTTTTANGGAATATTNNTGNAATGAAAAGNGGTC

GCCTATAGNGAGTCGTATTACAGTGGNGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGCNCGAGGCCTGGGACAGGCCAGTCCCGTTCCTTCCGCATNCTCGCCCACCTNACAG GCACCGAGTTCATGCAAGAACCCGGATGAGGAGCACNTGAANAATTNAANCCAGGTGCC

NAGGACGGAANCCCNACCCCAAGCNTAANNTAAACCCAAGNACCCNTGNCNNGGCCTNA

CAACCCCAANNCCAANAACCNGCCNNCCTTGGNGGGGGNNCCTTNNNTTNNNNNACCCN

NACCCCAAAACANAACNANANGGTGNTNAACCGGNANANACAAATCANGCACACACCAA

GCGTATGCAAAANACCGACCTTNATTTCGCAAGCCGCNCTTTANAGGGGNGCCTNTGGGG GGGNGGGGGGCACACAAAACGAAAAAAACTCCNTGTGCCACCCNAGGCCAAAGGGNTNN

CNNGGTGNCTTATNTNTTGNGGCTTNTC^

NCTCCCCACAAGTTGGGAAAAANNTTTNGAANAAAAANGGGNCGTTTTTTTTNAGANGAA

AANGGGGNCTTTTTTTNTCCNCCACHΓ^

GTNNNNTGTCAANTAAAAAAAAANTACNTGGTTGGAGGGNATTNACTCCCCCNTCNTNAA ANAAANNATGNGNCANAGGGTTTTGTTNTTTTNNTNCTGOW

NNTTTTTGANAANNNNTCTTTITTTTT^

GATTCATTNTTAAGATNTTTTGGTCNAAAA

NANNTTTTGGNGNACGNANTTTNNTTNAATN^ ATNANTTTTGTTTTNCGCGNCANTTTATTNATANNANANCCAGNGNTGNAAAANAAAATT

NTTNN

GCCTATAGNGAGTCGTATTACAGTGGNGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGCNCGAGGCCTGGGACAGGCCAGTCCCGTTCCTTCCGCATNCTCGCCCACCTNACAG GCACCGAGTTCATGCAAGAACCCGGATGAGGAGCACNTGAANAATTNAANCCAGGTGCC NAGGACGGAANCCCNACCCCAAGCNTAANNTAAACCCAAGNACCCNTGNCNNGGCCTNA CAACCCCAANNCCAANAACCNGCOSINCCTTGGNGGGGGNNCCTTNNNTITSπSINNNACCCN NACCCCAAAACANAACNANANGGTGNTNAACCGGNANANACAAATCANGCACACACCAA

GCGTATGCAAAANACCGACCTTNATTTCGCAAGCCGCNCTTTANAGGGGNGCCTNTGGGG GGGNGGGGGGCACACAAAACGAAAAAAACTCCNTGTGCCACCCNAGGCCAAAGGGNTNN OSINGGTGNCTTATNTNTTGNGGCTTNT^ NCTCCCCACAAGTTGGGAAAAANNTTTNGAANAAAAANGGGNCGTTTTTTTTNAGANG AANGGGGNCTTTTTTTNTCCNCCACNTNNTNANAATGATGNGNNNNTTATNCCA^

GTNNNNTGTCAANTAAAAAAAAANTACNTGGTTGGAGGGNATTNACTCCCCCNTCNTNAA ANAAANNATGNGNCANAGGGTTTTGTTNTTTTN^ NNTTTTTGANAANNNNTCTTTTTTTTTT^ GATTTATTNTTAAGATNTTTTGGTCNAAAAAANCT NANNTTTTGGNGNACGNANTTTNNTTNAATNAA^

ATNANTTTTGTTTTNCGCGNCANTTTATTNATANNANANCCAGNGNTGNAAAANAAAATT NTTNN

TTNANCAAANTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGGATGGTACAATCAAGGAAGTCGTTCTGGATCCAGACA CCACCTCTTACAGCCTGACGGATCTGAGCCCATCCACCTACTACACAGCCAGGATTCAGGC ACTGAACGGGACCCTAAGGAGCAAGACAGTCAAGACCNTCTTCACCACGAGTGGAGTCCT GTACCGATTCCCCAGGGACTGCTCCCAGGCAATGCTGAATGGAGACACGACCTCTGGCGG CTACACCATTTATCTGAACAACGACAAGACCCANAAGCAGGAAGTCTTCTGTGACATGAC

CTCTGA(^GGGGTGGATGGATTGNGTTCCTGANACGCAAAAATGGACGTGANGACTTNTA TTCGAACTGGNAAGGCTACCCTTNTTGANTTTGGGACNTNAAAAAANAAGTTTTGCNTTG GCTTGGACACTTTGNACCAAAATNCCAGCCCAGGGCCATACCAACCTCNGGTGGANCTTG CGGAACCCCGGGGAAGNCGGCCCAGNCCTTTTANAAAAAAGTTAANGTNGGGAAAAGCC CGGACCCCCTTNCCGGTTNAAGGNGGANGGGGTCCCANNGGCCCGGGAGGNGACCTCCTT

GGCCTTACCCAATNGGNNNAATCCTTTTTCCNCNTTTAAAAAGGGACAANNAATTNGGCC ATTAACCAANNTTGGGCCTTTT(^TTAAANGGGGGCNTTTTTTGNTNCAAA^ CCGGTTAAACCTGGGNGGGGGAAAANCNGGGGAAAACCCCCCCCAANNNNGGGGGGTTA ACCNGGGTTCCCCTTGGAANGGGGCCCCAAA(^TTTTAATTCCANTTTTNTTTAAAAANAA ANCTTTAAAACCCCCNNANTTTTT<^AAAACCTTTTAAAGGGGNGGGCCCAAAAANGGGC

TTAAANTTTTCCG

NCAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCGGGCTGCAG GNGAAAAGCCNTGNNATGANGAATGGAANAGAGTGGATTGGGAGCAATTATNCTTTTGN

CTGTCAAAATGAGTGCCTTTTTAGGAAATGTGGTTCCCAATTGTTGGTTTCCTGCCATCGT GTGTTCTAAGGAAAATTATCCATGGCTCATTAAAAAAAAAGTGCTTTATAGCACTGAGAT AAAATTTTACATGGATTAAAGTGATTTTGAGTATTTTAATCGNAATTCGTCCAAAATCAAT ATCACTGTGTATTTCTGAGCATTTTCAAGTCTTTTANTTACATTCAGCAAATTAATAATGAT ATAATAAATTTAAACAATAGACATTGGCGTGGTCTTTTTCAAAAGTACTTAAGATTTGATT

TATGGCTCTTACCCAAGAATCATCATGAAAAATCGATTTGTTCTGTAGCAGAACTCAGTAA GCATCTTCTTATTTCAAATGGCAATTTTATTTTAAAGACAGAACCACTTAATCTTGGAATA TTTGTTTCTTCAGTAAAGATTTCTGAAATTTCCATTTATTGGTCTTCTTTCCCCA^ TCATCCCACCTCATTCCAGATGTCCTACTTATGTTTTTCAAAAATGTACTTGAAAACTAATT GCCCCATCATGNGGGTATCAAATTAAATAAGTGATTCTCTGNGGCCAGTTGTCTTCTGGAA

CTTGGNGGGTAATGGAAANCCTGGATCTGCCAAGAAACTTTAAAGGGAAAGGGAGTAAC TGGGTTCTACTCCCCATGACCGGGGN(^GGGATTTCNTTTGGTNGAAAATCAAAATCATA ^' AGTTGGATTCNCTTAAATAAAGCCCCCAGGAATTAANGGGGTTAAAAATTCAATCTTTTA AATCCCTCCTTNCCAAAGTNAAAA TTNNNNCAACAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCC CGGGCTGCAGGNNANNNGCCCNGNNATGNAAAAAGGAAAAGAGNGGANNGNGAGCAAT TAGGCTTNTGNCTGTCANAATGAGNGCCTTTTTAGGAAATGTGGTTCCCAATNGNTGGCTT

NCTGCCATCGTGTGNTCTAAGGAAAATTATCCATGGCTCATTAAAAAAAAAGTGCTTTATA GCACTGANATAAAANNTTACATGGANCAANGGGATTTGGAGTATTCNAATCGCAGTNCGN CCAAAATCAATANCACTGTGTATTTCTGAGCATTTNCAAGTCTTTTAGTTNCATNCAGCAA ATGAATAGTGATCTAATAAATTAAANCAATNNACNTTGGCGTGGNCTTTTTCAAAAGANC TTAANATTGGNTTNATGGCTCTAACCCAAGAATNATCATGAAAAATCCATTTGTTCTGNAG

CAGACCTCANTAAGCATCTTNTTATTTCAAANGGCAATTTTATTTTAAGGACAGACCCCCT TAATCTTGGAATATTNGTTTCTTCAGNAAGNATTCTTGAAATTTCCATTNATNGGCCTTTπ TCCCCAACCCTAATCATCCCAACCTCAATTCCANANGTCCTACTTAATGTTTTTCAAAAAA NGTACTTGAAAAACTAATTGGCCACATCATGNGGGNAATNAAAATTAAAATAAGGGGATT TCTTNGGGGGCCCAGTTGGTNTTTTGGAACCTTTGNGGGGNNAATGGGAANCCCTGGGAT

CCTTGCCCAAAAAACCTTTAAANGGGGAAAGGGGAGTNAACCNGGGGTTCCCANCNCCCC CCAAGGACCGGGGGCCNGGGTNTTTCCTTTGGGNGGAAAAATCCAAAACCTTTGGTTGGA ATTTCCCCTAΛATAAGGCCCGGGAGGAATTAACGGGGTNAAAAATTCCAATCTTTTAAAA CCCCCCCTNCCCAAGGNNAAAAAAGCCTAAANGGN

TTNNGCACANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGTGCAAGTCTTTTAATAGATGTCATAACAGTGTTTGGAGAACTCACTGATGAAA ATGTGAAACACAGAAAGTATGCAAGGTGGAAGGCCACATATATTCATAATTGTTTAAAGA ATGGAGAGACTCCTCAAGCAGGGCCTGTTGGGATTGAAGAAGATAATGTAGATGTTGAGG

AAAATGAAGATGCTGGAGCCACCTCTCTGCCCACTCAGCCACTTCAGCCGTCATCTTCCAC ATATGACCCAAGCAACATGCCATCGAGCAGCTATACTGGAATCCAGATTCCCCCCGGTGC CCACGCTCCAGTAATACCCCAGCAGAAGTGCCTCACAGCACAGGTGTAACAAGTAACACT ATCCAGCCTACTCCACAGACTATTCCGGCCATTGATCCTGCACTCTTCAGTACAGTTTCCC AGGGAGATATCCGACTAACACCAGAGGACTTTGCTAGGGCTCAGAAATACTGCAAGTATG

CTGGCAGTGCTTTGCAGTATGAAGATGTCAGCACTGCAGTGCAGAATCTGCAGAAGGCCC TCAAGTTACTGACTACAGGCAGAGAATGAAGCCTTTGTCAACATCCATGCATTTTTTGGCT TAAAGAACTAACAGTCCACTACTCTATCTTCAGCCTATCAGGAGCACAGNTTTTAAGGAA GAACTTCAGTTNCATTGACTTTTAACCAATGAAAACTGGGGCTGGGGATCAAAATTCCTAT TGAAGTATTCATTAGCAGGCCTCAAACCAGNTTTCANTGGGCCATTTAANGGGATCCNGG

AAGNCCCTTAAGGGGATAAGCTTNTNTAATGGGGAACCANGGNCCCTTTTATTTGGCCCN C

GCCTATCTGGAGCTNCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCAGCCGCATCCCTGAGACAAGATGGTGAAGGTCGGAGTGAA CGGATTCGGCCGCATCGGGCGCCTGGTCACCAGGGCTGCTTTTAATTCTGGCAAAGTGGA CATCGTCGCCATCAATGACCCCTTCATTGACCTTCACTACATGGTCTACATGTTCCAGTAT GATTCCACCCACGGCAAGTTCAACGGCACAGTCAAGGCAGAGAACGGGAAGCTCGTCATC AATGGAAAGGCCATCACCATCTTCCAGGAGCGAGATCCTGCCAACATCAAGTGGGGTGAT

GCTGGTGCTGAGTATGTGGTGGAGTCCACTGGGGTCTTCACTACCATGGAGAAGGCTGGG GCTCACTTGAAGGGTGGCGCCAAGAGGGTCATCATCTCTGCACCTTCTGCCGATGCCCCCA TGTTTGTGATGGGCGTGAACCACGAGAAGTATAACAACACCCTCAAGATTGTCAGCAATG CCTCCTGCACCACCAACTGCTTGGCCCCCCTGGCCAAGGTCATCCATGACCACTTTGGCAT CGTGGAGGGACTTATGACCACTGTCCACGCCATCACTTGCCACCCANNAAGACTGTGGAT

GGCCCCTCCGGGGAAGCTGTGGCNGTGACGGCCGAAGGGCTTGCCCAGAATATCATTCCC TGCTTCTACTGGCGCTTGCAAAGGCCGTGGGCAAGGTCATTCCTTGAGCTCAACCGGGAA ACTTCACNTGGCATGGGCCTTTC(-^GTTCCCCACTTCCAACGTGTCTGTTTGTGGATNTGA ACCTNGCCGCCTTGGANNAAACCCTGGCCAAGTTTTGAATGAAGANCCAANAAAGGNNG GCGAAACCNNG(^GTCNNAAGGGCCCTCTTCAAGGGCAATTTCTNAGGCTTNCCOWGAG

GGACCCAGTTNNTNTCCCTNGGAATTTCAANAGAGAGAACCCTTNNTTTTTπ G AAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GTTCTTAATTATCACAGCAAATACTTTGGTCTGATTGTCTGTATCTTGTGACAAGCGATAA TGACCCAGTANAATTGCATCCGTTCTGGTATTCCTGGNGCGTAAGCGTGGAACAATGGAC TGGGGCTCCTCGGGCGTGGTGAGCATCATCACGTGGCCATCCGGGAAGAACCTTACGTAC CTGTAATATTCCACTTGGTGCCACGCTCTATANAAACCATCAAGANACTGCTCCCCTTGAC

AAATATAGGNGGTTTTACTGATATACACGCCATCAAATCGAACACGGGGCCTTTCCAAAA ACATCTCTCTCCANGATGTGTACGGAACAAGTTTAATACAGNTTCTGCCCCAANCTTTCAA GCAGGCCAAACGCCNTATTTGAGGGTNTCTGGCANANATANANAATCCTCTGCACACCTG TGACANCTGCTCTAATGATCTGANGTNCAGGTCGNTGCACACCACCCAACGNAAGACGTA CATCACGACCTCCATTGGCAGANCTTGATATATGAGTCNGACTGCTCTCAAGTTCAGGCTG

ACACAGNTNGAGCACAGACTTCTGAAACGTGAGCTGCTGTTGGAAGTAAGACANGANGTC TGNCATCTTGCTGCATCATCAGTATCTTCAATGNAGCTGGTTCCCACGCCNTCACCATTTG GAGACCGGGTATAAAGTAATCTTGAACTCTATATCAGGGACAAGTTGCATANCCCCTACA ANAAAACTTGGATGGGTTNATAAAAAAGCTCCATTTGGTCTTCNTCNACCGGNTTTTAAG AAAAAATTTTGGANGGGGGGGGCCCGGTACCCAATTTNGCCCCTTTAGNGGANNNANNN

NNNNAAANNNNINNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNC

GCCCTATNTGGAGNTGNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGCAAATTCCTTGCAGCAGGAACCCACTTAGGTGGCACCAACC TTGANCTTCCAAATGGGAACAAGTACAATCTANCAAAAGGGAAAAGTGATGGGATTCTAN ATCATAAATCTGAAGAAGANCGNGGGAAAAGCTTCTGGTGGNCGGTTGGGCCATTGGCGN CATTGAAAANCCGGNTNNNGGCAANGGCATANTCNTCAAGAATNNTNGNCNANGANCTN GGNTNAAATTTGNTNGTGGCNNTGGAACCNNTTCTANNGNTNGNCGGTTNANTTCGGGAA

CCTTTACTNACCAAANNOWGNCNINATTNAAGGANCCAANGNTTNTGGNGGNCACCGATC CCANGGCTNANCANCAACCCCTTACGGAANCCTTTTANNTGAACCTGNCAACCATTGGCC TGTGCAACANGGACTNTTCTCTGGGCTTCGTGGACATTGGCATTCCGTGCAACAACAANG GAGCGCACTCAGTGGGTCTGATGTGGTGGATGCNCTCCCCGGGGAANTCCTGCGCATGCG TGGGNACCANTTTTCCGAGAGCACNCCGNGGGGANGNGATG(^CGGAACTCTANTTNTNC

AGAGATATCTTGNGGAGAATTGAAAAAGGNANAAGCNCGGCNCCCANCTTGAGAA.A.AGC TGTGACCCAAAGGANGAGATTTCACNGGGGGAAAAGGACNTGGTTCCANNCCTNCANAN NNTTACAGGTTNGCTCCTACCCTGNNGGNGGGAAAACNNGNTCNTGAAAGNNGTGCAAN TTGCCTTTCCNGGCCCANTTTANCCAGNNTCCCCACTGGANNAAACNNGGAGGGCTTCAA CCCTTTCNNCTGAANNAATAGGGNNTNGNGNCCCCCCCACCCGCCCCANGTGNCCCNGGA

ANTGGGGTNGGAAAACCCCCCC

TNNANCCTATCTGGAGCTCCANCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCTCTGAAGGAAAGCAGAAAATAGTAGAAGGTGGAAATGGGCGAAAAGAGA

ATGCTCATTAGTAGCAGGAGAAACACAGGACANGGATCCCATCTTATTGGGGTTCTCAGA GGACAGCAGGACANTTTTTCAGGACTAGTAGGTAGGGCAGNGTGANAANCCCNTCNTCCA AAAANANANAGGTAANCCTTACCCNTTACNTNTAΑSTGGTTNTGGNGCCCCCAGGNNCAGC C⁽^TTTTTNNTANCCCAAAAAATTAGGGNCCCAAANAAGGGCACNCCCAGGGNCCAAAA NGNTGGTATTATANTTAGNAGGGAGGNTGATGGNAAGNACCCAAATCNTAAAGGCCAGG

TCNCCAANTTGAAACCAGGAAAGGGGGAGAGGAGATTAGGGAATCTCTGTGTNTNGNGC ACCCGGCTNTGGTCNCTCTTGTGGCAGTTTTTTTTAAAAANCNTTCTCTAGCTCTAGCCCN ATAACNNTGTAANATNTNCCNACCCNCCAGACCNGTGAGAGCCCTNCCCAAANTNTTGGG GGGAGAAGNGNGCTCTTTTCACATTTNAAGGGNCCNGNTNTTGTGANNANNTTCTTCTGA AGACTCTTNANTTCCTCTTGTTΓΓCCCCCCANAGGGNCTTNTTGNAAAAAAAGGAGGACCC

CCCCTCCCCCCANTATTAACCCCCCANAAGAAGAACNGGAAGANNCCTTCCTTNTTCCCCC NCC<^CCTCTTGCCNTAATTTTCCCCGCCTGGTC^ TTTTTOWAACGGCCTNGGAAGGGAAGTNCHNRC^

TNNANCCTATCTGGAGCTCCANCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGCTCTGAAGGAAAGCAGAAAATAGTAGAAGGTGGAAATGGGCGAAAAGAGA

ATGCTCATTAGTAGCAGGAGAAACACAGGACANGGATCCCATCTTATTGGGGTTCTCAGA GGACAGCAGGACANTTTTTCAGGACTAGTAGGTAGGGCAGNGTGANAANCeCNTCNTCCA AAAANANANAGGTAANCCTTACCCNTTACNTNTACNGGTTNTGGNGCCCCCAGGNNCAGC CCNTTTTTNNTANCCCAAAAAATTAGGGNCCCAAANAAGGGCACNCCCAGGGNCCAAAA NGNTGGTATTATANTTAGNAGGGAGGNTGATGGNAAGNACCCAAATCNTAAAGGCCAGG TCNCCAANTTGAAACCAGGAAAGGGGGAGAGGAGATTAGGGAATCTCTGTGTNTNGNGC

ACCCGGCTNTGGTCNCTCTTGTGGCAGTTTTTTTTAAAAANC^TTCTCTAGCTCTAGCCCN ATAA( NNTGTAANATNTNCO fACCCNCCAGACCNGTGAGAGCCCTNCCCAAANTNTTGGG GGGAGAAGNGNGCTCTTTTCACATTTNAAGGGNCCNGNTNTTGTGANNANNTTCTTCTGA AGACTCTTNANTTCCTCTTGTTTTCCCCCCANAGGGNCTTNTTGNAAAAAAAGGAGGACCC CCCCTCCCCCCANTATTAACCCCCCANAAGAAGAACNGGAAGANNCCTTCCTTNTTCCCCC

NCC(^CCTCTTGC(_^TAATTTTCCCCGCCTGGTCTTGTTTTAAAAAAAACNN

TTGANNAAANTCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGNANGAGGCTTNNCNNTCCNGNNGACCTCGAGGNGGGGNCCCGG NGCCCNNTNNNGCATATANTNACTCGNATTACNTGTNNNTCTTTANNGNNTGTNACNTAC TAGGGCGAATGGATGAANTGAAAGTTGGAGGAAANGANCTATTNGACTTAANANGCTNT TNATGTATCNNAGCTGCTNTGANTGGANGTGCCNATNNTNCGAAGAATTACACCTTTTAT

GANGGCCCAAAGACATATATTNTCANAAACTGNNNNTGACACAGNCACAGCGCTTCTGGA CCTGTTTCAAAAATNTTAGAATATTTGNAATATATANGATNCGGTCTTTNCGCTGGNTAAA CGATANAGCCAGNTTNGTGGAGTNTGCATANANNAAANTNANNGGCCTCGGCCCNNAAA ANAAANCTNCCNTTTTTTTTTTACNNNCCCTTT(^CCCGCTTGGCTTC NAGGNNTGGAANAATAATTTAAATGGσSfCCCCTTTTAANGANTGCCNACAAATTTTTGAA

NGGCTTAGGCCNAGTTTTCCCCCTNGGGCANNAACCCTTNCNTTTNNATTTO NGNTTNCCAGGGGGNCATTNTCTTTTTGGA

GTTTNNCCNTTANTTAATTGGNCCCATNTNNNTTTAAAAAAACOSfGGGGNCCCCCCATGA ANACCNGGCCCNTTTGTTTTNAATCCCCCCCTTTTTTTNAGGGGAAN^ AANNNNNNNAACCCCCCCNNNAAAACCCTNTTCCNCCTCCCNNTNNAAACCNNACCNNN

NTCNA<^TTNGNACCTTGGGNNCCANNGGGGGAAAAAAAACCCCCCNTTNTGGNGNNAC CTNCT

NCANNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGCTTNNTGGGGNCTGAGCCGAGCCGAGGCCTGACTGCTCCCG CCGNCCACAAGCTGCTGTCACNGGGCTCTGCACAGACAGGTANAGGGCACCNAATTCCGG AGCGCCTACAGCCTGGACAAGCTGTACCCGGAATCGNGGGGCGCGGACACCGCCTGGAG GGTCCCGGGCNACGCAAAGCAAGGCAACGATGACATTCCTGTNTATCGCTTGACGATATN

TNACTGTCGGANCAGTGGTCCTGGGGGCCAGAACGTTAACAAANNGAACTCCAAGGCTGA AGTCAGGNTCCACCTGGCAAGCGCCGACTGNATCGCAGAGCCCGTGCGGNAGAAGATGG CTCTCACGCACAAAAATAAGATCAACAGGGCGGGAGAGCTGATCCTCACGTCTGAATACA GCCGCTATCAGTTCCGAAACCTGGCAGATTGCCTNCAGAAAATTCGAGACATGATTGCCG AGGCCAGCCAGCCAGCCACAGAGCCATNCAAAGAAGATGCTTGCCTTCAGAAACTCANG

ATAGAAAACATTGAATCGCGAAANGGTTCCGAAAAAAAGANAATAAACITITGNCATTNA ANACGAGCAGGAGGGTCGGTACCGGACTTGAAAGCACCCCTTCGAGCCAGCAAAANCCC CTTCANGGCCNCCCAGGTGGGTTCGGACACCAAGAAAACGGGNGTCTGGTCCGGGGCACT TGGTCGNNTTTTACCGTNGGAANCCGTNGNAAAAAAGGTCCTTTCGGGAACCNAAGGTTT GTAAGNCCCTGGGCCNCCCAAGGTNNTTTTAAAGGGGAAAACCCGNGTTTTTNCCANCCT

TTCGTTTTNCCATTNGNCCCGGNNTTAANTTGGCAATNAAAAATTNTTNAAACπ AAAAAT

NCANNANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGCTTNNTGGGGNCTGAGCCGAGCCGAGGCCTGACTGCTCCCG CCGNCCACAAGCTGCTGTCACNGGGCTCTGCACAGACAGGTANAGGGCACCNAATTCCGG AGCGCCTACAGCCTGGACAAGCTGTACCCGGAATCGNGGGGCGCGGACACCGCCTGGAG GGTCCCGGGCNACGCAAAGCAAGGCAACGATGACATTCCTGTNTATCGCTTGACGATATN TNACTGTCGGANCAGTGGTCCTGGGGGCCAGAACGTTAACAAANNGAACTCCAAGGCTGA AGTCAGGNTCCACCTGGCAAGCGCCGACTGNATCGCAGAGCCCGTGCGGNAGAAGATGG CTCTCACGCACAAAAATAAGATCAACAGGGCGGGAGAGCTGATCCTCACGTCTGAATACA GCCGCTATCAGTTCCGAAACCTGGCAGATTGCCTNCAGAAAATTCGAGACATGATTGCCG AGGCCAGCCAGCCAGCCACAGAGCCATNCAAAGAAGATGCTTGCCTTCAGAAACTCANG

ATAGAAAACATTGAATCGCGAAANGGTTCCGAAAAAAAGANAATAAACTTTTGNCATTNA ANACGAGCAGGAGGGTCGGTACCGGACTTGAAAGCACCCCTTCGAGCCAGCAAAANCCC CTTCANGGCCNCCCAGGTGGGTTCGGACACCAAGAAAACGGGNGTCTGGTCCGGGGCACT TGGTCGNNTTTTACCGTNGGAANCCGTNGNAAAAAAGGTCCTTTCGGGAACCNAAGGTTT GTAAGNCCCTGGGCCNCCCAAGGTNNTTTTAAAGGGGAAAACCCGNGTTTTTNCCANCCT

TTCGTTTTNCCATTNGNCCCGGNNTTAANTTGGCAATNAAAAATTNTTNAAACT^ AAAAAT

TTNAACAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGNNNNNANGGNGGNGNTCNTNGANCTCGCNCTGCTGGAGNGGGGNCNNGGGCN GNNNNNNGGNNTCNAGTGCNGCGCTNAAGNCGAGCGCCAGATTCCAGTTCTTCAGACAA ACAATGGTCCGAGTCTAACGGGACTGACTACCATAGCAGCTCACCTAGTCAAGCAGGCCA ACAAGGAGTATTTGCTGGGGAGCACGGCAGAGGAGAAAGCCGTGGTTCAGCAGTGGTTA GAGTACAGGGTAACGCGAGTGGACGGACACTCCAGTAAAGATGACATCCACACGGTCCTG

AAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTTACAGGATATAACTTCACATTAG CAGATATCCTATTATATTATGGGCTTCATCGCTTTATTGTTGACCTGACAGTTCAAGAGAA, GGAGAAATATCTTAACGTGTCGCGCTGGTTTTGTCACATTCAGCACTGTCCAGGGATTAGG CAGCATCTGTCTAGTGTTGTCTTCATCAAGAACAGACTATATACTAATTCCCAGTAGAAGC CACCCGCGCCCCGGCCAGAAGAAGGAATAACCCATGTCCAGTGGGNAAGTGNGGTTTCNG

ANCCANAGGACTGACGTGNACCTGATTTCNTTCATTTCTTNTATTTGGTNGAAANTTGGTA AAAATTTAAAGTACCAACCTCTTGTCCCCAAGCATTTTTGGGCTGGGTTTTTTAAANTGGA CCANTTTTTGCCAAGTTTTTTTTTTTAATGGNAAAAAACTTπ^ AACCTTTGGGGTTGGGAAAATCCAAGGTTTTTTCAAGTTO^ ACCCTTAAGATTGGAAAATTTTTNTGGGTNAAANAAAAAAGTTGGCCA

GCCNATNNGGAGNNCGCATNACAGGGGGCGGCCGCTCTANAACTTGTGGATCCCCCGGGC TGCAGGCTTCAGGGCAAAAANGNNNAGTNCTTCTAGAAAGTACNAGNGCTTGTGCCTGCT CCTGGGGGGAAGGGACCTTNNCGGATNTGAGGGTTAANCCTTANAGAAATNAGCTGTTGT

GTAATACAANGANATCTACAATGACACCGACAGCCTGTTCCCAACAAGTCCTNNGCATCC TCTTCCTAAAGAGGACCCTTTTCATCTCTCCTAGNAGACCAGGAAGNATNTTCATCCTACC CAGGAGAAANTTGTAGGAGAAGGCGCCTACAGAGGATGACTTCTAAGCGATGTTTGCTAA GGAGAGAGGGCACNGANAGATGCCATAATACNTTGATTGGNCTGTGAATTTAACCTCCCT ACCGTGGTAACCTCACNCNCTGTGCCANNGGCCTTGAGTTGTGTGGAAACAGCCCANAAG

GCATTAGNCTACNTGCAGGCTCTTGGGTGCTAAANAGCTTGACCTTCCTGGGCANNGTNT GCCTGNATTGGNCCNGTCGANCGNNANNTGGAGTTATAANGATGTNTGGCTTCCCATTGG TNCCACTTCCAAGTCCTGTTTCACACNCCATANATAC^TTTAAGCCNNGTGCANNANACNT NCANAANTNTGNGNATTTCCCTGCGGNGCTATCGANTGAAANATTNTATGNNGTCCCNGN NTCTNANNANNGCGNC(^TTGCTGGNCCNTTTGNTNGNANGNGGNCCTTCTATCTAAACC

TGTAANNGGNAGTCACNCTANNCNNTCTCTTCATNGTCCTTCCNANTGGNGNGNNNCCTT NGGAACCTCTCCTTTNGAGNNCNNNNNNANCGTNCCNGGTCNAAAATNANGCCTCGGAG NTAATNTCNTTTANTNTTNNNANCAACTTTTTTGNNNNNNTAATAT^ NNTTCTTNTCNTNCTGNNNTNCCTANTNTNTNANOS1NTATTCNGNTTNCNCNNNGAATTGC N(^TCNNCANCTTNATCTCNTATATNC(^CTNTTCNTCGNAANNCNNCCCTATTAATCTTT

NNTNACCC

NCAANANCTGGAGCTCCACCGCGGGGGGCGGCCCGCTCTAGAACTAGTGGAATCCCCCGG GCTTNAAGCCGNTNGCGGAANCCGGTGGGGAGGCGGCTGTCCGGGCTGAGGGCCGCCAC

AGGGCGCCGGCGAGATGGAGGTGACGGGGTTGTCGGCNCCCACAGNGAACGTGTTCATC AGCAGCTNTNTCAACAGNTTTCGTTCCCAAAANCGGNNCAGNOSINANCCTNNCCGNACNT AATTNAAANGNNAANNANCANTTNGTGTGGGGCAACCTGNTTCTTGNNTGTNANANNAG CTGTNTGNACCTGACAACANNNTTTGTTGTAANCTNNATCACNATGATACGCTNCTGGGCT CCTACCACCCAGANGACGACTGGTGCATCCNTNTTNTTGNCCACCACGGNGCCCCCCTTTN TGAGNATGAATGACATATCTAAGNNGGGNNAATATGNAATATCTOS1NAAAAGCNNTTGTA NAGAAAGNGAGGAANTANTOSINTCCTTTCCTTAAANGCANCANAANNNGGNTNNGTNTA TTTAAAAAAAAANGGGGCCNCCCCAANGANNNGGAAANATCAC^TCCCTTTTTTTANGGA GGAGGACGGGNCAAGCCATANTNNTTGTGTGCAGCCCNTTNGGATGNTANGACCCCTGAG

CCAGCCCCCNTCCCATNGGGGNNCCGTACTTNTTTTGTNNNNTTGNAO^ NNGNNTTTTGGTATTNGGGATTCGNNTTTOSINTTAACCCCAAACGNAAAAA^ CNCTNGGCAATGGTGAAAACTTTTTTTTTATTTTTGATNGCNANGN^ TCTTTTΠWINTTAAAANGGGGNAAANTTNTO^ TTAGANTGNNACCNNAANGGGNGAGGGNNNNNNTCTTTNNTTNNNCTNNNNNCCC^

TNCCTTCTTCTTTNNTISINTNN^ TACNTNCCNNCCCCNCCN

GCCCTATNNGGAGCTGCANCNCNGGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC

TGCAGGGNACNTTGNGTANAGAGATCCTCTTGCGAGAGCTANAGGTGCCGGCGNGCNTGN CCCTGGAGANCNTTCTGATTCCCTTCCTTNNGGNNATGGGGGATCANAAGCNGNTTTNAN ACCTTTTTAAGGTNCCGGNTAGNACAAANGANCTNGNGCCNGCCCATTNTNNACANCCNT TGNACCTTΑSRGGACCCCGAGAAACGAAAAGAATTTNTTAACANCNNNCTTGGCTTGGCCT TTTNAATN(^AAGANT INNGGNACN™^

CNTTATNGANGNAAACGATCGGNATNTAGAANTAANGGGNCAGANTGNNGTNTTCCNGA AGCACCCCCGCAAAGCGGCCATTCTNAACATGCCGNTGGNGA(^A(^CTCTTNTACTCNN GCTTNTACCACTACACACGAGGCTGAGGGGACGTTCNGCNCCCCANNGCAACCTGTNAGA NAGACGTGTANGATNCCACACAAACAGGTACANGCTGNCACCGCTGTCTCGCTCNCGCCC (3SINCTCTCNGGCCCTGNGATTGNCATCAGATGCCCCTGTNTACCACCAACNAANATGTNT

GGTGCTNCCCCCCACNAAANANAGCNGCCCCCNCTGANNNCCCCTCNGNNNCGTGGNAG ATTTTTGC^CCANCNAATATTGGCCCCCNGTTNCAGGANNTTTCNNGANGNGTGTNCCATC NTNGTGNAAGAATGCCCTCCCCCACNGNNGGAACTTNNGCCCCCNCCNGGTCCCACTAGT NNCTTGATTGNNGGGNNTTGGTATANCTTTNCCGGNCGANCCTNNAANNNATCNNTCCNT CCTNTTTNGTTTCNCACLSFNCCCNGCANNCNNCNNGNGGGCTNTANANGGNTTCTTTNNCG

GNGGAAGGAAGAAAAAANTNGANTNGCCCNTTCTTNAANANANC

NNCAAANCTGGAGCTCCACCGCGGGGGGCGGCCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGATTNOSINCACGAGGCCNCAGTGTGGNACNTNTGGNNTNNACNNTCGANCAAA

AGCNNCGTNGCCTGGTN WCGGANAANATTNCNGGANTTNNAGNCCCCAAGGGGGNCTT ACCNTTC<_^GGGCCOSrCCANCNTTTTNAGGGN^

ACNATAGTTN(^TTATTTNNCCANNAO^GAAANAAGACNCCGGAATNANAATGAACNTG GGCCCANNNNTGGNTCGNCGGACαsfNTNCTTNGAAGTAAGGTTCTGGNCCCGGGGGTNGC ^' TGGGTTTNCATAAACGGGGCCTCTNCATTGGGGGCTCTATCCCGCGANCCATNTTGTGGNC

ATTTGAGTNCANNGGATAAANTCTCTCTNTCTATNCACGNGGGGGGGGGGGCTCTCTCTG AGAAANNCACTCCTGTGNCCCNNTTTCTCTNAANAAATGGGGTGGGGCANAATCTCGTGN TTTTTTGCNGCCCCTCTCCNGTGTGANANGGCNNCATGNCGCTGNTTCTTACTANTAATAA TGCNCTTNATACCCNNNATAAAAANNTTTTAAANCANNNGGGGGGGGCCNNNCCCCCNN GGGGGGCNCNNGGGGNNNNNTTTNTTNN^

NNNNNNNNTSINNNNNNNNNNNNNNNNNN^

NNNNNΠSINNNNNNNNNNNNNNNTSΠSINN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNN^MNINNNNNNNNNNNNNNNN^

NNCAAANCTGGAGCTCCACCGCGGGGGGCGGCCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGATTNCNNCACGAGGCCNCAGTGTGGNACNTNTGGNNTNNACNNTCGANCAAA AGOSINCGTNGCCTGGTNNNCGGANAANATTNCNGGANTTNNAGNCCCCAAGGGGGNCTT

ACWATAGTTN(^TTATTTNNCCANNAαSIGAAANAAGACNCCGGAATNANAATGAACNTG GGCCCANNNNTGGNTCGNCGGAC(-Ms[TNCTTNGAAGTAAGGTTCTGGNCCCGGGGGTNGC TGGGTTTNCATAAACGGGGCCTCTNCATTGGGGGCTCTATCCCGCGANCCATNTTGTGGNC ATTTGAGTNCANNGGATAAANTCTCTCTNTCTATNCACGNGGGGGGGGGGGCTCTCTCTG AGAAArWCACTCCTGTGNCCαSINTTTCTCTNAANAAATGGGGTGGGGCANAATCTCGTGN TTITTTGCNGCCCCTCTCCNGTGTGANANGGCNNCATGNCGCTGNTTCTTACTANTAATAA TG(-NCTTNATACCCNNNATAAAAANNTT^

GGGGGGOSrCNNGGGGNNNNNTTTNTTNNNNNNNNN^ NNNNτ>INNNNNNNNN^

NNNM^πSINNISINNNNNNNNNNN^

NNNNNNNNNNNINNNNNNNNNNNN^

NNNNNNNNNNNTSINNNNNNNNNNNNN^

TTNANAAAATCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGGCCGGGTTGAGAGGAGCGTGGCCTTCTCCTCTCCCCGCCATGGCGTGTGCTC GTCCACTGATATCAGNGTACTCCGAAAAGGGGGAGTCCTCTGGCAAAAANGTCACTTTGC CTGCTGTGTTCAAGGCTCCCATTCGACCCGATATTGTTAANTTTGTTCACNCCANCTTGCG CAAAANCANCANACAGCCCTATGCTGTNAGTGAATTANCAGGNNATCAANCCAGNGCTG

AGTCTTGGGGTNCCGGCANAGCTGNGGCTCGAATTCCCAGGGTTCGAGGTGGCGGANCTC ACCGTTCCGGNCAGGGCNCTTTTGAAACCNTGTGTCNNGGGGCCCGANNGTTTGCCCCAN NTAAAACNTGNCAACGTTGGCCCCNGNAAAGNGAATNCAACCCAAAACCNATNCCCNTT NNGTTTTGCANTGNTTGCCTAAACCTTACNAGGGNTGGTNATGTTTAAAGGNNATCNTAT AAAGGAAGTTCCTGAACTTCCTTTGGGGGGGGAAAANAAAGTNGAAGGTTACAAAAAAA

CCAAGGGAGGTTGGTTOWITITNAAAAAACTT^

TNTNTNCCNTTTAAGNAATGAAACCTGGCNAAGGCAAAAAANAAAAACCGGNNCCCGTN TCCAGCCCANGGGGACCCTTGGTTTTTTTTTAAGNGGGGCCAANGGNTTTTTTCAAGGCCN TTNAAAAAAATCCCCGGGAAANACCCTTGGNTNAANGGGAACCCAACCTTNAACANTTTT GNAAACTTTTTCCCCTGGGGGGGNACCNNGGGAAA(_^TTTTTTGCATTTTGG

AAGGCTTTTTCCCAAAAGTTTNAAAAAAANCTTOT CCCNCCN

NAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC

AGGAATTCGATATCAAGCTNATNGATACCGNCTACCTNGNGGGNNGGCCNGGGNCCCANT TTACCCTATAGTGAGTCTGATTANAGAGGNCCCTCCCAAAACCCTTGTTGAAACAGCCAA NGAAGCCAAGGAGAANGCCNANGAGACGGCACTGGCAGCTACAGAGAANGCCAAGGAC CTTGCCAGCAAGGCANCCACCAANAAGCAGCAGCAGCAGCAGCAGTTCGTGTAGCCAGC CCAGGCCCTGAAGCANCAGCCTAACANACTACCANCTCCAGGCCCTGTGCCCCCTCCTCTT

GTACTTTATTATTAAAAGCCAGCTTCTAGCCCTCTCGACTGTCTGGGTGGTGGGCTGAGGG TAGGTGCCCTGTTTGCATCTCCAGCATAGCCAGCTGGTTACCCATATCTGAGCCGGCTTCC TTACCCCTGCATCGGGTGGCTGANGACAGAAGCACAGTGACTTGCCCACGGTCACCGNAT CCANGTGAAGTGGTCATGAATGCTANACTGTAAGCTCCATGAAGGCANGGACCGNTGTTT ATCCTTCTGATGTGTCCCCAAGTATNTTGAAACAAAATTTGCGTGTAACANGCACTTCAAT

AAATACTTTGTTGAATTCAATCGGACCCCAGAANAAAAAAAAAANNNTNTNNNAANTNTN GNGGGGGGGGGCCCGNCCCCAANTTNNCCCTTTNNTGGGGGGGGNNNNTTAAAANNNNN NNNTTNNNTTNNNNTS1NGNNNGNNNNTS1N CCNTSπSlNNNNNNNNNAAANN^

TNNNNNAAAAGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC GGGCTGCAGGAATTCGGCACGAGGGCTCAGCCTGTCCATCGAGGGTCCCAGCAAAGTAGA CATCAACACAGAGGACCTGGAGGATGGCACATGCAGGGTCACCTACTGCCCCACGGAGCC

TGGCAACTATATCATCAACATCAAGTTTGCTGACCAGCACGTGCCTGGCAGCCCCTTCTCC GTGAAGGTGACAGGCGAGGGGCGTGTGAAAGAGAGCATCACGCGCAGGCGACGGGCCCC ATCGGTGGCTAATGTTGGCAGTCACTGTGACCTCAGCCTCAAGATCCCAGAAATTAGCATC CAGGACATGACAGCCCAGGTGACTAGCCCATCAGGCAAGAGCCACGAGGCCGAGATTGT GGAAGGGGAGAACCATACCTATTGCATCCGCTTTGTGCCAGCTGAGATGGGCATGCACAC

GGTCAGCGTCAAGTACAAGGGCCAGCACGTGCCCGGGAGCCCTTTCCAGTTCACCGTGGG GCCCCTGGGGGAAGGGGGAGCCCACAAGGTCCGTGCCGGGGGCCCTGGCCTGGAAAGGG CTGAAGCTGGAGTGCCAACCGAATTCAACATTTGGACCCNGGAAGCTTGCCNCGGGGGGC CTGGCCATTGTTGTCGAGGGCCCCAACCAAGGGCGAAAATTTCCTTCAAGGACCGGAAGG ATGGGTTCCTTGNGGCGTGGGNTTTACGNGGNCCANGGAGCCAGGNGAACTTTTGAGGGG NOSINTCAAGTTTNAANNGGGGGGGCCCATNCCCCCCNAAANNNCCCNTTTTCGGGGGGCC CNGGGGGGTTTTTCCCGGTGGGGGACNCCCCCCCCCCCTTACTGGGTTTTAAGGNTTTTAG

NAATNGGGGGCCCAANG

TNNNNAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGGGNGTTGCTGCTNCTTGCGCTGTGCGCCGCANGCGCCCGN NGGCTTTATTNCCACNTAGGANANACCGAANANCGCTGNTTCATCGAAGAAATCCCCGAC

NAGACCATGGTCATCGGGAACTACCGNACNCANNTGTGGGANNANCAGANGGAGGNNTT NCTGCCNTCGACCCNCGNNCTGNNCATGCACGNGNAGGTGAANGACNNTGAAGGCAANG TGGTGCTNT(^CGGCAGNACGGATCAGAGGGCCGTTTNACCTTNNCTTCCCACACTCCTGG AGACCATCAGATTNGCCTGCACTCCAACTCTACCAGGATGGCTNTCTTTGCTGGCAGGCAG ACTGCTTGTACACCTAGACATCCAGGTTGGGGAGCATACCAACAACTACCCTGAGATTGC

TNGCCAAGGATAAGACTTGACGNGAGCTACAGCTCCGAGCCCGCCAGCTGCTTGATCAGG TGGACANATCCAGCAAGGAGCTTGGATTACCAAAGGTATCGTNAAGAGCGCTTCCGTCTG ATNAGTGGACANNACCACCCANAGGGTTCTGNGGTGGNCCATNGCTCAAACTGTTATCCT TATCCTTCACTGGNATCATGGCCNATCC(^ANCTTAAGAACTTCTTTTTAAGNCCAAAAGC TGGTGNAAATGGCCTCACCAACGNGAAACCTTTCCTGGGANCCTAAAGNAATTNGGTACC

TTTCCCCCACNCAATATCNTTATCC(^CCTGGAATTTTTGAGGGAAAAAAAAAANTGAAA AAAAANAATNTTCTCCCCCNT GGTTNCCTTNGG

AAAACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGCTTTGCTCCAGTCAATGTAACAACTGAAGTGAAGTCTGTAGAAATGCACCATGAAGCA TTGAGTGAAGCCCTTCCTGGGGACAATGTGGGCTTTAATGTCAAAAACGTGTCTGTCAAA GATGTCCGTCGTGGCAATGTGGCTGGTGACAGCAAAAATGATCCACCCATGGAAGCTGCT GGCTTCACAGCTCAGGTGATTATTTTGAACCATCCAGGCCAAATCAGTGCTGGATATGCAC

CTGTGCTGGATTGTCACACAGCTCACATTGCTTGCAAGTTTGCTGAGCTGAAGGAGAAGAT TGATCGTCGTTCTGGGAAAAAGCTGGAAGATGGCCCTAAATTCTTGAAATCTGGTGACGC TGCCATCGTTGATATGGTTCCTGGCAAGCCCATGTGTGTCGAGAGCTTCTCTGATTATCCT CCCCTGGGCCGTTTTGCTGTGCGTGACATGAGACAGACAGTCGCTGTGGGTGTCATCAAA GCAGTGGACAAGAAGGCAGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCA

GAAGGCTAAATGAATATTATCCCCAATACCTGCCACCCCAGTCTTAATCAGTGGTGGAAA GAACGGTCTCAAAACTGTTTGTCTCAATTGGCCATTTAAGTTTAATAAGTAAAAGACTGGT TAATGATAACAATGCATCGTAAAACCTTCAANAAGGAAANGGAGAATGGTTTTTGTGGGA CCATATGTTTTGTGGGGTGGCAANTTTAAAGTTATTAGTTTTTTNAAAATCAAGTACCTTTT TTAATGAAAAACCAACCTGGCCCAAAAAATCTGGNCACAGAAATTTGGAGACCCNTTTAA

AAAAAGGTTTAATGANNAAAAAAAAAAAAAAAAAACTTCGNGGGGGGGCCCGGNCCCNA TTTGCCCTTTNNTGGNGNNNNNNNNNTTNTNANNNC

CAAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGTGCTAGTTTGAAAGTGGCTGCAGCCATTGCTGGCTATGTGTTTAGAGACAAGGTGAGA TCAGAATTTAATAAGGACTTCCGGCAGCAGATGAAGAATTATCCAAAAGACAACCAGACG GCATCGATCCTGGATAAGATGCAGAAAGATTTTGAGTGCTGCGGGGCGGCTAACTACACA GACTGGGAGAAGATCCTGGCCGTGACCAATAAAGTCCCTGACTCCTGCTGCGTCAATATC ACTCATAACTGTGGGATTAATTTCGTTGTGAAGGACATCCATACTGAGGGCTGTGTGGAG

AAGATTGCGGCCTGGCTGAGGAAGAATGTGCTGGTGGTGGCTGCGGCAGCCCTAGGCATT GCCTTTGTGGAGATCCTGGGTATTGTCTTAGCATGCTGCCTTGTGAAGAGCATCCGAAGTG GCTATGAGGTGATGTAGGGGGTCTGTCTCTTCAGCCCCCTCATCCAGGGGAGTGGGGTAA TATACTCCAGGTTTTTCAATTAAACGGATTATTTTTTCAGACCCCAAAAAAAAAAAAAA^ AAAAACCTGGGGGGGGGGNCCCGNCCCCNNTTCNCCNTTTANGGGNGGNTTNANNCNNN

NNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNTSINNNNNNNNN^ NNNNNNNNNNNNNNNNNN^ NNNNNNNNΉTSINNNNNNNNNNNNNI^^ NNNNNNNNNQ NN^

NAAAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGGAATTCGGCACGAGGTAAACGAATACATTAACGGTGCTAAACACAGAACATTTTAA ACCCCAGGTCCCGGACATTTCTTAAGCTGGTAACCTTCAAGCCTTCTTCACGGGCCTTCTT GNTTACCCNTGAATGGGCCCGNTTTNCTTTTGNCGGGGGNNCCTTCNNCCATTGGCTTGGN GGNACATGGGNGGAACANTTGATCTGNTNNANNCTGGCTTNAANACNOSINTGGNTTTTTA NAATTTNTNNNTTTNTGGTNAAAANNNATN^

NNTTNAGGNATTGGCNNGCNNGGGGGCATNCCTTANNGGNCNGNANANNGNCNAAGGGA AATAACNNGCACCTNANGGTGGCNANGATNCNTCTAAGGCNAAANGAACAATGGTGGGA GANACCNGCCNAATCCACCACNCCCNAACTGGAGATAACNAATCTTATGGTCACNGGGCN GTGACNGACACAAANGAGAACTGAGAGGTGTGGGTCTGANAAGNNCANATAACTCTTCT ACACTATTACNCCANATTCTTTTCACATATTCCCCCTCTCTCACTTTTGCNGAAGCGCANTT

CNNCCCNTCTCTGGNNATCCCCCCNCACCCTCTGTNGAGNGGGNNTAACCATGTGCTGCG GGGGTGGTTCCCCTCCTAAANTACTCTTTTTTGAAGATGCAGCGACANNGGNGGCTTGTTT TTNCCCCCAAAANAACCNCANTTCTNNAAGCCGAGGGGCCCCAACGTNGGGGNANAAAA ACAAAAAAANGGCGGGGGGGGNGGAAATGGGGGTTNCTNTTTGGGGGGGTTCCNGGGGN

CCTTTTTTTCAACANCNTGGANGGNGNGNNCNCCACCNN

AAAACTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGANTNNNNCACGNGGCCNCAGTGTGGNACCTATGGNATNTACNNTCGANTCAAGAANN

ACGTNGACTGTANANNGAANACAATGCATGAGTATNNNGCNCCNAGGNTNCACTAACCA TNCANGGNCCACCANNCTCTCTAAGGGCTGNNACC(^TNTNGACTTTCTCTTNCTNACAAT AGTTCCATTATTTCACCATGACTGAGGACAGGACACGGNAGTGANANTGAGCTAGNGCCA NGACTTGNTTGNCNGGACACTGNNTNGGAGGTACGNTNCTGNTNCTGTGGCTGNNNNNGT NNTNCANNANNNGGGGNCTANCTACATGGGGGCCTCTACCNCGANNCCNTNCTNNGGAC

TTGANNGTACANGGNANAC(^TCTCTTTNTCTATTCATGGGGTGGGGGGTCCTCTNTCTGA NATAACCCATTCCTGTCACCANTTATTGACTGATNAAANTNGCTGNGANGGCATTCTCTTG ATGCCTTGNNGGCATCCCCCTNNACCTGTNTNAANNGGACCACATGGCCNTTTGNTATGN ACTCGGAATNAAG(^TGNNTATAACCTTTAATAAAATCTTTTTAAAACACGGGGGGGGGG CCCNGCCCCCNTGGGGGCCCNNTGGGGGCCCCNATNNCCCCTATGGGGGNGNNGNNNAN

CANNNNNNCNNNNNNNNNNNNNNCNNTNCNNNNNNCN^ NNNOSINNNNNNOSINNNNNNNCMNNNNN^ NNNISINlSINNNCN πSINNN^ NNNNNCCC NNNNCCNCTANCNNN^^

AAAACTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGANTNNNNCACGNGGCCNCAGTGTGGNACCTATGGNATNTACNNTCGANTCAAGAANN ACGTNGACTGTANANNGAANACAATGCATGAGTATNNNGCNCCNAGGNTNCACTAACCA TNCANGGNCCACCANNCTCTCTAAGGGCTGNNACCCNTNTNGACTTTCTCTTNCTNACAAT

AGTTCCATTATTTCACCATGACTGAGGACAGGACACGGNAGTGANANTGAGCTAGNGCCA NGACTTGNTTGN(^GGACACTGNNTNGGAGGTACGNTNCTGNTNCTGTGGCTGNNNNNGT NNTNCANNANNNGGGGNCTANCTACATGGGGGCCTCTACCNCGANNCCNTNCTNNGGAC TTGANNGTACANGGNANACCNTCTCTTTNTCTATTCATGGGGTGGGGGGTCCTCTNTCTGA NATAACCCATTCCTGTCACCANTTATTGACTGATNAAANTNGCTGNGANGGCATTCTCTTG

ATGCCTTGNNGGCATCCCCCTNNACCTGTNTNAANNGGACCACATGGC(-^TTTGNTATGN ACTCGGAATNAAGCNTGNNTATAACCTTTAATAAAATCTTTTTAAAACACGGGGGGGGGG CCCNGCCCC(^TGGGGGCCCNNTGGGGGCCCCNATNNCCCCTATGGGGGNGNNGNNNAN CANNNTNINNCNNNNNNNNNNNN^ NNNCNNNNNNNCNNNNNNNNOS[NNNNNN(^

NNNNNNNNNCNNNNNNNNNNNNNTNNANTNNT^^ NNNTSπSfCCCNNNNNCCNCTANCNNNNTNNNNN⁽^AαsrTNNNN^ TTNNNNAAANNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCCTGAAGACTCTGGTGGCTAAGGGGCTTCATCCCAGC TGAGAAGCGAAGAGCCGCAGGCGGCCGCCGACTTCACAGCCGCTCGGGGTTTTTAGAGCT TCAGCTATAAAAATGGGCAGGATTTTCCTTGATCATATCGGTGGTNCCCGTCTGTTTTCCT GTGCAAACTGTGATNCGANCNTGNCCANCCGTTCAAAANTCATCTNTACTCGGTTCACAG

GCGCCANTGGCANAGCNTTTNTTTTTANCAAGGNAGTTANCCTN(^GTNTAGNGAAGTTN AGAATCGGGNNNTNCTCANTGGCCGCCACNTGGTTCNNNANGTGAGCTGCAAAACNNGC ATTANCAANCTGGGATGGATNTATAAGTTTGCCANTGANAACNGCCAGNGTTATAAGGAA GGNCGNGNNATCNTGGACCGCCCCTTTTANTNCANAAAAAGNNAGGGCTTTTGAGGGANC ATGTNCNNTCTGATACCTNTGGAAAAAAAAAAANAAAAATCCNTNTTTTCCCAGGTCTCC

TTTCACTGAAAAACAAAAANTTTACTTACATACCCTTGTCCCCTTAACATTNAAAGTCGGA TTT(^TGAACCTGGGGNAACAAAAANTTTGGGGAAAAATTTTTGAAGGGANCCTTCCCTT

AAANAAAAATTTTTCCCCAAAGNCCCCGTTTTTTTTTTT^^ CCCNNNGGGGGGGGNAAAAAANTTTTTTTTCCCCCCCC(^CCTGGGGGGGGNTTTTGGGN

GAGNAAAAAAAAATTNGGGGGTTTTTTTAAAAGGGGGGGAAANN TTNNNANAGAGGAAAGGGGGNNCNAAAN

AAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGAATTCGGCACGAGGOSrAGNCTNTTTTNCCNNTNNCNTNGGNNGNCTGAANGCTTGGAN CCCCTCCCNTNGGAANAAGANGCNTAAAACTCNGANANCGNCGGNTACATGCCATTNNTG AGGNCACACCNCCGAAANNAANTGGGTCCAACCANCTCCAAGCTTGCCNAATTCGGNGN CACGNAACATGNTAGGAANGCCTTTTTTGCCNNACCCGNCGATGNAAANCGAGCNTCACN TTTGTGGNAGANCCNANTTCANANAAAANAAGGAGGGNTTTCAACWACAGATTTTATTAG

NATA(- ACATNGATACTATANNTCNCCCATGGNACAAATCCATGATTNAGAGGATNNTAA GANCGAGGCANNCAGGGNGNTTTATTTACANGAAACATTNNNGCCTTTACCGAATNNATC TC(^GATGCNTNNCTTTTCAATGCTGTGCACTCGNGGAACAAAAATAAAATCCCCTGATTG CCAGGNATTGACCCNATNAATGGGAACGCACTTmTNTNCTNACCCACAGACCAATTNTT AΛGTTCCNCCNCCTTTTTATGTGTTGATTTGCCCAAGNCCGCCTTATGANCTTTT^

ACAAATNGNAANCGGGACCTAACATAACCNOSrCCTTGNTTCCCCGGGACCCTTNCAAAAA TTTAAGCCTTGAACCGTTTTNCTCGGCNACCCGGNGGGGCTTGCCCTANCCCCCCNCTNGA AAAAAAANGGGGAATTTTTTAAAAAAATTTTTNTCCNAAAGNGGGGGGCCCTπ CAGGTNGTTNTTAAAAACCCNCCAANTTTCCTGNAAAAGNGGAAAGGGTTNC(-^TTNGGC CTTAAAAAAANCCC^TTTTAAAAAATTTTNTTNGGGAAAAAAAGGAAATTGTT

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCAACAACCTCTTGAAGTGACCGTTCCTGCCCCAGGCTTCCAACACAGCCATGTCTCT CCTCCTGCTGGTGGTCTCTGCCCTCCACATCCTCATTCTCATCCTGCTTTTCGTGGCCACTT

TGGACAAGTCCTGGTGGACTCTCCCCGGCAAGGAGTCCCTGAATCTCTGGTACGACTGCA CATGGAATAGTGACAACAAAACGTGGGCCTGCAGTAACGTCAGTGAGAACGGCTGGCTG AAGGCAGTACAAGTCCTCATGGTGCTTTCCCTCATCCTCTGCTGTCTGTCCTTCATCCTGTT CATGTTCCAGCTCTACACCATGCGGCGAGGAGGGCTATTCTATGCCACTGGCTTCTGCCAG CTTTGCACCAGCGTGGCGGTGTTTACCGGGGCGCTGATCTACGCCATTCATGCCGAANAG

ATTCTGGCGGACCGCCCGTCGGGGGGCAGCTTTGGTTACTGCTTCGCCCTGGCCTGGGTGG CCTTTCCCCTCGCCCTGGCCAGCGGCATCATCTACATNCACTTGCGGAANCCGGAGTGAAG GCTTGCNCCTNCCCTTGGTTNCCCAANCGANTTCCCGGGCCCTTCATTNTAACCCGCAAGC CCCCANCCTTTCTT(^TTTTTATTTTAAACAAAAAAATAAAACTGGTTAANCCGCCGGAA^ AAAAAAAAAAAAAAAACTTGNNGGGGGGGGCCCGGANCCCAAATTNNCCCTTTAANNNN

NGGGGGGNNNNNNTSINNNAAAANNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNT^^ NNNNNNNNNNNNNNNNNNNNNNNNNTSπ^ N

TTTGANNCNATCTGGAGCTCCANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTNNNCACGAGGATNNTNNNTNNCTGANNNANTGTTCAAGNACNGCNC

TGGGNANNNTTANTNNTGGNGNGTCNTNCNCTGNNGANNCTTANTATNAAANTGNNTNTN NNNNTCACTTANNACAAGATCTGNTGCANNCNCNCAGTGNTNNANNCαSfTCNNACNGNG NTNCTANTGNCCATGGAATNNNGNTATGGTGACGNNGAC(^ANACNACCNTTNNTGANAT NCTNTGTNNTANANNNCCNGATTTGNTTNNGANAGTGANNCATCATANTCTTNGGGNTGC CCNTGATCNTNATCANGNTGNAGTATNTANACCNTGCACTGANGNGGGCTATACATATAN GACGTGTCTTTTGCCATGTTTGCNCCACNCANGGTATAGTGTTANTNGGATCTAATNATCT

AAGCCGANTTNTG(^GAAGACTGTCTTGNATTANCCCTNNTCTTNTTGNAAGAATTTGNNT ANCTGATTCGANCTTGGGNTAGTTGGGCNTTTTTCC^

ATNATANGTNCCACTTTGNGACTATCTGNCAGNTTTANGGNCTTGTTCCNTTGCCAATTGT TTTAGOSINTTTNCα^CC<^CCCCCCCCCCCCCCCCCCTTNTTTTTANAAGNT^

TTTNTTTTTNNNCAATAAATTTTN^

NTTNANAATTGNNATTNTTNTCOSπSINCTNATNNTNATTTCCANNCTNCA^ AAATTATNTTTTCCNAAANAGGTTCNCCTTNNNNACANNNTTNNTANKAT^ NNAGNTTCTTTTNNAAAAACATTTTTC

GCCTATNTGGAGNTGNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTGCTGACGGACCTGTGGAGCTCCTGGCACTCCTGGACCTCAAGGTATTGCTGGACA GCGTGGTGTGGTCGGCCTGCCTGGTCAGAGAGGAGAAAGAGGCTTCCCTGGTCTTCCTGG CCCCTCTGGTGAACCCGGCAAACAAGGTCCTTCTGGAGCAAGTGGTGAACGTGGCCCCCC

TGGTCCCATGGGCCCCCCTGGATTGGCTGGACCCCCTGGCGAGTCTGGACGTGAGGGAGC TCCTGGTGCTGAAGGATCCCCTGGACGAGATGGTTCTCCTGGCGCCAAGGGTGACCGTGG TGAGACCGGCCCTGCTGGACCTCCTGGTGCTCCTGGCGCTCCCGGTGCCCCCGGCCCTGTC GGACCTGCCGGCAAGAGCGGTGATCGTGGTGAGACCGGTCCTGCTGGTCCTGCTGGTCCC ATTGGCCCCGTTGGTGCCCGTGGCCCCGCTGGACCCCAAGGCCCCCGTGGTGACAAGGGT

GAGACAGGCGAACAGGGCGACAGAGGCATTAAGGGTCACCGTGGCTTCTCTGGTCTCCAG GGTCCCCCCGGCCCTCCCGGCTCTCCTGGTGAGCAAGGTCCTTCCGGAGCCTCTGTCCTGC TGGTCCCCGCGGTCCCCCTTGCTTCTGCTGGTTTCTCCCGGGCAAAAGAATGGACTCANTG GGTCTTCCCAGGCCCCATCGGTCCCCCTGGGCCCTTNAAGGTCCCAACTGGNGAATGCTTG GTCCTTGCTTGGTCCTTCCCGGNCCCTCCNTGGACCCCCTTGNTNCCCCAAGGTCCTTCCA

AGCGGGCGGGNTTNCNAATTTGANCTTCCTGNCCCANNCCACCTTAAANAAAAAGGCTCA CCNAATGGTGGCCCGTTNCTANCCGGGCTTNTTAATNCCAATGGTGGTCCTTNAAOWNA CCNTCAAGTGNGGANANCCNCCCCTTAAAAACCTNANCCNANNTAANT

NCANNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCGGGC TGCAGGCACCCATCAACCCCCAAGCTGAAGTTCTATTTAAACTATTCCCTGAACACTATTA ATATAGTTCCATAAATACAAAGAGCCTTATCAGTATTAAATTTATCAAAAATCCCAATAAC TCAACACAGAATTTGCACCCTAACCAAATATTACAAACACCACTAGCTAACATAACACGC CCATACACAGACCACAGAATGAATTACCTACGCAGGGGGTAATGTACATAACATTAATGT

AATAAAGACATAATATGTATATAGNACATTAAATTATATGCCCCATGCATATAAGCAAGT ACATGACCTCTATAGCAGNACATAATACATATAATTATTGACTGNACATAGTACATTATGT CAAATTCATT(^TGATAGTATATCTATTATATATTCCNTACCATNAGATNACNANCTTAAC NANGNNGCNGGGANACACCACCCNCTTGGTAGGGANGCCTTTTTTTNTTNCCNGCCCATA AAACGGGGGGGGGGGGGTTTTTANGGAATTTNNCNCGNCTT^

CTTTTTTTTAAAAAGGGGCCNTTNTTTTNNTT^ ATGGGGTAATAAANCCCCTNNGNC(^COSfAAAAAAGGNGGGGNGGGGNNAAANNTTNGG

TANCCCCNGGAAATNTATTTNGGGGGGGGGNTATTAAANGGNTTTTTGGGGCCCCCCCCT TNTGGNAANAGNNGNGGOSfTTTCσSfGNNNNTNGGGGGCCCAGGNTNTTATTTT^^

TTTNCCCCCNTTTNAAAAAANTTTCCCCTTATNATTCNNCCαSTNCCC^ TTNC(^AAAAANNTNATTTNAAAATTTTCCαSINNNNT^

NNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGGNATNTCCTCCOSINNGCCCACAGGCACNNαS[NCTATCCGGNAC<-^TNAGGNNNCN C(-MNNGCCTTCαSTTGGNCTTTGAGCNNGGNATAA(^TATTTATGATGGNANACCGGGCAC NCTTGGGAATGGNCAAAANGGNTNNGCTNCNNNNTTGGGGCTNGNNGNCGGCTTANNTG AANNNNAGATNTNGNGNCCTNTNGGGACCTTGGAAANGGGACGNCCCCTTNTCNNATGN NGAANTTANAACTCCTGAACCCCTGGANGNCCNGCNTANNAGAAGCCCCCTCAACCNGA AANCCCTGCCCTTTITSiNNNCTTTrc^

AATCGACNTTCCAGNNNNNCCNTTCTATTTTNAAAATI Π^ TNNΪOTAAGACAGCAOSΪCACHTTGTCTAN^ AATNTCAAGCNCTAGANTTTGATAGGGGNNACAAAAACCCCRCGGGTTNNTAAGATGCCT

TCAGNNGGATNTCAGGNGGTNNCCTTCTAGTGCHNGGNNAANGGNGNNGCCCACTTTCAT TIΉCCTGGGGCCCNTGTTΓCGGANAANTTTCTGGGAGGNNTGCCTNTTGCAAAAGGNGAT TTOSRCCCCCC^CCGCCCCTTCTTG^

CCNNGANGGGGGGGTCCCNNNCGNNTNNCGNCNTATNNCCCANGANCCCTCGCCACCAT NGTNGGT FNCAANAANNNTGGGGGNNTTTTGAAATTTNTCCGGNCGAGNTCCCKTGGAAN

NRØJTCTNNNGANAAAAATGTTCCTCTCCCCCCNCCNNGTNNNTTSTNTATGGGNCGCNNACT TGGTGGNCCCCCCC-NNCTTTNNTNC^GCANNCGCCGCCNCTTTNTTTT^ NNNATTTTNNNAAGGNTTAANNNGTCCCCC

NNNTNNNNNGACGNC( NCNNN(^ANNACTNCNANGACNTNNAGTANAGANGAGTGCTNC GCACGLSINGNTCTRNNGNI> GANNCGNGGGTΑWAGACTAGGCCTNCCNTCGNTTTNGGN GNOSINNNTNTGGCAGNTCGCATNACNAGTGGGCGGCCNCNTCCTATAATNAGTGCCGTTC CCCCTTTTRMCNCNAANTGGTATTANCATNTATTTTTANNCCNCANNAAANCTCTO

CGNCNCTNGGGGACTTNATTAANCTTGNTOWTTTATCANTNGCTNTCCCNCNGTCCTCAN

CCNCNTATNTNCNCTATCGTRØTCNCTCTTTTNTCTNTTNTNAACTNACNCNACACTACCA

ANNCTNCAANATANTNNCCTCATNATGNANC WNCTNNNNNCTAGN]SΠΓC

TANTCATT AT C i TAm TTAMW^ NNCTNCACATANGNCTNNNTTGTNATNNCNCANTNCTNTAGNCAGACCCCATNNTCTCNA

TNCn NTTN TATNACKNTCNTC^^

NCNCGGACTACCANNCNCAATAATANATNANANTCACTGCCTNTCNNANNCNCCNGAAN

GGTTGACNNNTNCCTCGTRØRØT^CTGANNCNCNCCCCCGTCATANCTTTNANGATTGCCN

NANCAGNA CCCCNCAGNNNACTNA 1S[N^WGA TANCCT INTTATTCTCTNNCAATNCT^ TCTCACCACANTTNTNTTTATNANATNANTGACCGACAGTNCCTCGATTNTTCCTNGACTC

CCTCTTTTCNACNCNACCAACANTCCNCNTGATACCNCNATAGTCCCTCTNATNCTNTTAT NNNNCACTACCCNTNNNCCTNCCT(^ANNNTATCTN(^TTANNCCNNGTCTATNATAAGT TCTTTCNTNCNNGTATTCNTCT(^CNNTTCCCCACCCNTCNANCACACNCTANCTNTNNCT TCCCTANTNNGNTNATITAGANCNNNNGNNTTATTNNTCCAAGTANTGTNTNTCTΓANGTN NCNANCTTNTATNCNGTCGTATNCCACTGACCAANCCTCTGTANTANACTCACGTATCCTN TNATCN(_MTAATTATAGNCTTCTNGCNCTAGTNGNATNGTNTTTAGNATCAACTGCNNCCC CTNCNGATNTTTCCTCTATTATNNTCTNGTANTNNTGANOWAACACCACMSICNNTCANTC CTCANCNGANGTGAGNCNNCCATCGATNANTACACTCCGTATCTCNTNNTTNTCNTCTNTG TNCCCCNCTNCTCTNTCNTACM^TCGCCMTACNGTGTNNATCTANATCGCTCTCGTATCΠSΠSI ACCTCTNNTNTNCNCCGTATNNNGNNNTCACTCINAIWITCNATNCACACGTNGNTNTACT AAANCTNANNNNTTAATNNCTCATTAGGTCCTO^ GTNCTNANAAACGCGTNCCCAACCNTATATGGATCTNACTCTATTGTGTΓNCTCTCATATC

Ai ^NrmTNACNCTAGGTNAGTNT^ TTNCGGNNNTATNNCG

GANACCCGANANTTANACNNTΓNTCTNNAOT

NNNTNNNNNGACGNC(^CNNNCNANNACTN(^ANGA<^TNNAGTANAGANGAGTGCTNC

GCACGNNGNTCTTNNGNNJ^GATSΠSICGNGGGTCMSFAGACTAGGCCTNCC^TCGLNRRTTNGGN GNΑWNNTNTGGCAGNTCGCATNACNAGTGGGCGGCCNCNTCCTATAATNAGTGCCGTTC

CCCCTIΎΓTTNCNCNAANTGGTATTAN^

CGN< JCMGGGGACTTNATTAANCTTGNTC^

CCNCWTAΗSFTN(^CTATCGTCMTCNCTCTTL NTCTNTT^

ANNCTNCAANATANT WCCTCATNATGNANCNNNCTNNNNNCTAGNNT(^T^ TANTCATTTATTOSΠSΠSITATNA^

NNCrøCACATANGNCTNNNTTGTNA

TNCTNTNTTNATATNACIWTCMTCGAC^TΓTNANAC^CNACAGTCANNTN^ NCNCGGACTACCANNCNCAATAATANATNANANTCACTGCCTNTCNNANNCNCCNGAAN NANCAGNANCCCCNCAGNNNACTNANNNNNGAATANCCTNNTTATTCTCTNNCAATNCTT TCTCACCACANTπsrmTTTATNANATNANTGACCGACAGTNCCTCGATTNTTCCTNGACTC CCTCTTTTCNA(^C^ACCAACANTC ^CNTGATAC(^CNATAGTCCCTCTNATNCTNTTAT NNNNCACTACCCOTNNNCCTNCCTC^^ TCTrTC^TNCNNGTATTCMTCTCNCNNTTCCCCACCCNTCNANCACAαSICTANCTNTN^

TCCCTANTNNGNTNATTTAGANCNNNNGNNTTATTNNTCCAAGTANTGTNTNTCT^^ NC^ANCTTNTATNCNGTCGTATNCCACTGACCAANCCTCTGTANTANACTCACGTATCCTN TNATC^C^rrAATTATAGNCTrCTΗGCNCTAGTNGNATNGTNTTTAGNATCAACTGCNNCCC CTNα^GATNTTTCCTCTATTATNNTCTNGTANTNNTGANQWAACACCAO^ mccccNCTMπcTTNTCNTAαw

ACCTCTNNTNTN(^CCGTATNNNGNNNTCACTCTNATNNTCMATNCACACGTNGNTNTACT AAANCΗVFANNNNTTAATNNCTCATTAGGTCCTNCNCTATNCTCACCTNCTNCRTATGGCΠ GTNCTNANAAACGCGTNCCCAACOSTTATATGGATCTNACTCTATTGTGTTNCTCTCATATC ATNNANTTNTNACNCTAGGTNAGTNTCNTATAGNACGANNATTΓTNGO^ANAAGCNTTAN

TTNCGGNNNTATNNCG

TTNNAAAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGGAGTTCTGGAGCCAGTATCGGATCAATGTGACTGAAGTGAACCCCCTGGGGG

CCAGCACCCGCCTGCTGGATGTGAGCTTGCANAGCATNTTGCGCCCTGACCCGCCCCAGG GCCTGCGGGTAGAGTCAGTGCCTGGNTATCCTCGCCGCCTGCGTGCTAGCTGGACNTACC NTGCNTCNTGGCCCCGCCAGCCCCANTTCNTGNTNAAGTTCCGTNTGCAGTACCGTCCAGC ANAGNATCCAGCCTGGTNTACGGTGNANCCAGNTGNATNGAAGGAGGTAATNACCGATN CTGTGGNTGGCKTGCCC3SrATGTA JNGCGGGTNACCGCCCGGAACTTTNTGNATGCTGGCA

CCTGAANNTCNTGAAGCCCCAAGGCCTGGGGGANTCCAAGCACTGANCCCTTACCAAAGG AAATGCCANTTGGGGACCAGCACCCCCCNCCAGACGGAGGAANAACCTTNGGCANACAG CCCCCGTTTCCC(^AAAGCCGTNCNTTTITACCCAAACCCANAGCCANT1TGACCANAAAA AACCCCCTGGAACAAGNGGCCCGCCCTGGCANTITTTGGNAAATTTTNTTTTTCTTGGNAC TGGGGGCTTGGGGCCCTTGGCATTNGGGGCTTTGGNTAANGGTTGAAACCAAATGAAAAN

GGGTGGGCCCCCNAAAAATTrøGGNTTTTTGGNCCCCAAAAGATTTTAAGGGGAAAAACN TTTCAAGGAANCCCCAACCCTNTNAAAGGACCCTTGGNGGG

CCAAAAGGTGGGGGGGGGGNGGGNGGGGCAAAAAANNAAAACCCCCGGGGGGGNAAAA NAAAATNCCCCCTNGGGGGGGGGGGTTTTTAAAAATGGNAAAANTTTTTTTTGGGANCCC CCMTTΓTTTTTTNNAA

TNNNNCAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGGCACGAGGCAGGACACAGGTGTCGTGAAAACCACCGTTAAACCTAA GCCAAAATGGGAAAGGAGAAGACCCACATCAACATCGTTGTCATTGGGCACGTAGATTCA

GGGAAGTCTACCACGACTGGCCATCTGATNTACNAATGTGGCGGGATCGACAANAGANCA NTNGAAAAGTNNGANATGGANNGTGCCGAGATGGGAAAGGGCTCCTTCAAATATGCCTG GGTCTTGGACAAACTTAAAGCTGAACGTGAGCGTGGTATCACCATTGATATCTCCCTGTGG AAATTTGAGACCAGCAAGTACTATGTTACCATCATTGATGCCCCAGGACACAGAGACTTC ATCAAAAACATGATTACAGGCACATCCCAGGCTGACTGTGCTGTCCTGATCGNTGCTGCTG

GNGTΓGGNGAATTNGAAGCCGGTATCTNCANGAACGGGCAGACCCGTGAGCATGCCCTTT TGNC TACACCCTGGGTGTGAAACAACTATTNGTTGGCGTTAACAAAATGGATTGCACTG GCCCCCTTTACCCNTAACAAATACTAATAATTTGTGNANGAAGCTAACNCCTATGTTAAGA AAAANGGCNTCAGCCCCTACCCACAAACATCGTGCCAATTTNTGGCTTGGGAANGGGGAC AACNΓΓGCTTNAANCAAANGCTAATTTTGCCTTGGGTCAAGGGATGGGAAGGNCACCCGT

AAGGGCCGGGAATGCCAANGGGAACCCCCCTGGTTGAAACTTΓΓGGAATGGNTTΓTTGGC CCCCAANTTTGGCCAAANTGAAAAAACCCTTTC^TTTGGCTΓΓTTCCGGGGGNGGNCAAA AAAAANGGGGGGGTTTTGGGNCCTGGCCCCTGNGGGGGC

AAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGAAAAACAAAACGGACCCGGGGGTACATGCGACCCTGAAGTCA CTCAGTAGTCAGATTGAAACCATGCGCAGCCCTGATGGCTCTAGAAAGCACCCTGCCCGG ACTTGTGATGATTTAAAGCTTTGCCATTCTGCAAAGAAGAGCGGAGAGTACTGGATΓGAC CCTAACCAGGGATCTGCTGAAGATGCAATCAAAGTTTACTGCAACATGGAAACAGGAGAA ACATGTATTTCAGCAAATCCATCCAGTGTACCACGTAAAACCTGGTGGGCCAGCAAATCT CCTGATAATAAGCCTGTTTGGTATGGTCTTGATATGAATCGAGGATCTCAGTTTGTTTATG GAGACCACCAGTCACCTAATGCAGCCATTACTCAGATGACCTTCTTGCGCCTTTTATCGAA

AGAAGCCTCCCAGAACATCACCTACATCTGTAAAAACAGTGTAGGATACATGGATGATCA AGCTAAGAACTTGAAGAAAGCTGGGGTTCTCAAAGGGTCAAATGACTTAAAAATCAAAGC AGANGGGAACCGTTAGATTCANATACATAGTTCTTCATGAATTCTTGCTCTAAACGAAATG GNAACGNGGGCAANACCNTCTTTGAATNTANAACGCAAATGNGGCACGCTTGNCCATCAT ANATCTTGGCCCCTGGGGATGTTNGCAGTACCANANCCAANAANTTTGGCGTTGAAATTN

GGGCCCANTTTGNTTTGGGTTAAAGCCAAGNCCGNNATCCCTTGGNCANTGGGCCCCCCC CCCCTTACCCTTAGNGGNCCCCCCCCCTTTCCCCAANAANTTTTTACTGGTTTGAAACCTG AACCCTGGNAAC(^TTTGAAANAANGGGGTGGANTTTGGCCTCCANCCCNTN

TTGANCNCNNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGNNCCNNN<^AO INTTNNTCNATGGGGGGNNCCTNGGTC AACGCNNGGTTCATTNTANNCNNGCATGANCNTANNANCACCCGGCNTTGGTGACCGCNN NCCCCNCTNACACGTTGAANATCATTANTATTTCTATCTCACACANGNCTCATTCGAAGCT AGCCCTCGCCGAGTNTGTATTNNTCNANTCANNTNTTNATTATANNNNNNCTTTTTT^

TNCNAACGNCANNCNACTCNGNTTNANTTTTTANNCAGNGNACTATACCΓΠTSINN^ CNAAAGGTTNATAAGACTCAACCNNANNGGNGTACCTGGNGACNATNTCNNNNNTTNNC AGCATNGAATTTATACTATAATGTTTCAGTCAATATAATTCCACTTAATAATTAGNGAAAA TTTCATATTATCCTAAGTATTACAGNATTAGTCCATTTTTTTCTTCTCCTAAATGAGGAGTG GTTTATTΓCCTCNGCGGNTTATATCATTAACTTTCTTTAATTCTTTTNTGNGCTGNGNGNAA

TATNGATAANATTACNGACCCCCTATAAAATAAATGNAAATTAAAAAAAAAAAACCCCCN CCCCCCGGGGGGGNCGGGAANNNNNGGTNCNCNCTTAANNTGGNGNNNTTTNNAANCCC C 3NTTNGGTT]NINNCCCCCNNTTNGGN^ NOSINNNGGNNCCGNAAAAANNNCCCCNGGGGGGNGGGNCCNCAANTNGNNNNGGNCCC NNTTTTNNGNCCCCNNNTTTTNNAAAANNANNNNCCN^

OSπslNTTTTGGCCCNNGGGGCCT

GCCTATANNGAGNTGNATNNCAGNGGCGGCCGNTCTAGAACTAGTGGATCCCCCGGGCTG NAGGAATTCGATATCANGCTTATCGATACCGACGACCTCGAGGGGGGGCCCGGAACNNA

NTTNNCCCTATNGTGAGTCNNATTNCAAGAATAAACGGATCTTGAATAAAAAAAAAAAAA

AAAAACCNGGGGGGGGANCCGNNCCOSINATTTCCCCTNNNAGGNGNTTTANTAAAAAGG

ACTGTNACTGTGNNNTCAGTGAACGNNNGCTNANANTCANCCNNCTNACNCTCCTGTACC

ACANGNGNTATTNAACTNGGGGNTNTTATTAAGACTT^ CNTTTGNAANCTTNTCCNNTGCAGTGNTGTCAAATATNNNCNGNNNAATTTCTCTAAANN

NNANAOSINCTNCTNNTTTAT^^

NNTWAATGTAANTTA<^ANNCTTNGATAAACCCGTNATNNANTANACNNTNACCAAANCT

GNNATNGANGTGNCTAAAAAANATNATlSINα^

NGNCNONINATTNTTTNTTNNNAT^ TTTNCTANAATTNCAATTTCCTANTNπ^

NCAANTGANCTTNTGAAAANTNTAANNANNNATNCANTNCTCNANNANCTANANNNANN

TANGGAAATTNATNTNGNNTGCNTTTTTATTANNTTTNNNTT^

AATCTNATATTNNCTTTNNTAANNNTCT^

CNNACGNAATNCNNCNTNGNTNCANTANCCATNNTTNTNNCTANTATTNTCTNCAANANN CNGCAATCANCATCTGNANATCCTANOWGCTGTNGTCATCTACATACNNTNNATNTNTA

NNTGNCTTNANANCGTANTNCAANTCANTCT^

NACT

NNNNACTGGAGCTCCANCGCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTTG

AGGGCCCNGGCTGGATCAGCTGCTGGGGACACTCTGACCCCTCAATGCGGGCCTTCCTGC TCTCCCTGGCTGCCCTGCGTGACAACCACACCCACTCCGACATCCAGGTGAAACTCTTTGT GGTCCCTGCGGACNATGCCCAGGCCCGAATCCNTTATGCCCGCGTNAACCATAACAAGTA CATGGTGACTGAACGGGCCACCTACATCGGAACCTNCAANTGGTNTGGCANCTACTTCAC CGAGACGGCNGGCACCTCTCTGCTGGTGACACAAAACGGGCGGGGTGGCCTGNGGAGCC AGCTGGANGCCGTGTTCCTGAGGGACTGGGACTCCCNTTATAGCCATGACCTTGACGCTG CCGCNGACAGCGTGGGCAACGCCTGTCGNCTGCTCTGAGGCCCGGTCCGATGGCCAGGCC AGGCCTGCAAGGCCCTGGTGTTCCGGGTCTCCATCCCCTGTCCCTGTGCCCCCCGNTTTTG TCTGACCCGTTGTGACTNCAACAGGCTCCCNCTTAGCAACCACCCCCACCCCAGCCTTTCA

TTTCTACCTCCACCCCCNNTTGGNCTGATGCTTGTGGGCCCCAAGAAGACCCANCCGAGCT GNGGGAAGGGCTCAATNCCCAAAAANAAAAGTGGGGGGTGCATGCTTNGCCTTACCTTCC TGGGCCAACCCCANTTTCCAGGGCAAAGNAAGGCCCCAGGTNATAAATAAAAAAGTCAA ATTACTTTGGNTTTNAAAAAAAAAAAAAAAAAAAANTNGGGGGGGGGGCCCCCNNNCCC AATTTTCCCTTAAANANGGNNNTNIN^

TNNTNNNNANNNTNNNNANNNNNNNNNNANNN^ NNTNNNNNNNANNNNNNNNTNNNNNNNNNNNN^

GCCCTATCTGGAGCTNNANCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGAATTCGGCACGAGGCTGGNATACAGGAGGCCCTCCTACTTCTCTGGGAACTGCCG GACGAATTAAAGTGGGGNACTGGAAGTGCTNTAAGGGAAAAAAAGANCNCGCGTCTTCA TTCATTTGAAGANCTNAATAA⁽^CTTTCCATGAAGCTGGTTGNGGGGGGNGNGGCANA NTCCTACTGNATTCCCGTANANNGGGCTGNTATGGGNGCGGCCCACTTATTANAACANAN AGGCCGCTGNCCGAGGNTNACTTCCACNCNCCTTTTCCTGGCTTGAGGCNCCCAAACTNCT

CAAANCTANACNGGCTGCTTCTNANAATTTCANGGAGGCGGGAGAAGTATAACCCCCCTG GGGAAGAGGGGGCCACATGATGTGGTTCANCTGGAAGACACGCACACCACATGCTCTCTG GGATNCTCTGTACAGAACGGACNACACTTGNNTCNACGCCNANNGTCACATNTCGACTGN GCAACTCTTANNATNNAAGGACCCCTCGGGCC(^GTGGCTGTTNATATGCNCTATTTTGGA AAAAAAACACAAATTTGTAGGAAATACCNNTTTTTTTTNACATTNNTNAA

CTGAGACCCCGGGTCAGGGTTTTTTCATTTNAAAAATGTGNTCTGCTTNTTATNGGGGCCA AAAAGTTGAAACAGCNTTNCCCCTGTTTTTCCCCCATCANNAAGGGNNACAACANCCANG TTCGNCCTTCNTTTTTTTTTTTTTCCCCCCACCCACTTGGCNACCCCCCAAGCN^ TNTAAANTGTTNNCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCNTTTTNAANGGTANCT CTCCTNCTTCCACGCATTNNNTTNNNNGGANGCGGNTTGNNTCTTTNTCCGCANNCAT^

TCNNNCNNCACACTNCATCNATANNCTNCCG

TGAGNCCNTNANNGNNTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

NTNCTNNTC⁽^AAAAANNAATNGGNTNCATNGCTNCC(^AANCGGNNGTCNNCCAAAAA NGCGNATGTNCTTNGNAAGGGNNAACTTNTNNTANAAAAACCCCNNNGNGGTNGGNAGG GNNGACCCAAAGGNNANAAACAAACTNGTANGGCCNNGNCNTCGGGNNGNTNCCCGGTT TCANGNTTNGNGAANNTGGNATNAAACCTNCNGNCCTTCCNANTTNTGCCNNTNTGAACN OvπS[GGGGATTTGNGGAGAGANNCCCACNNGA(^GTTTNTTTNNNAGNANNGNCAANCA

NGNGCGACANNTNTA<^ATGTNGAAANNCCAANACTTCTO^

TGAANGGGAGAATAAGGGCNTTTCTTTGTGGNANAAANACCCTNATAAAGCNCCCTGGGA CNCAATGTTNTGGNNCCCTGGNCC3SIN<^GCACAAAAANTTNNANNGGNNTANCNNNTCCT NNTNCCCANANTCNTANAGGGAATTTCNTTAAAAATNTCTGNNNCTNAANTNNTTCNCAA AGTTNTT AAANATGNCAGNCNNACN^^

TTTGGNCCNNNN<^CN[NGNGTATAAANTTC CACNNCNNNNATTATATATNGGNGNGGGONINAOT^

NGTTTNACTCACTNNTAACOSINNNGTCNNGNTNGTCCTCTTTATGNCANANNCAAAATCT CCNAC^CTTCGCTTGAATTCNACCNNAAACCTTTTNCCTNCAAATTNCCTAATNCTCNTGG TTNTNTCACTANAATAACATNNNNANAAANNNNCTCNCGNTTTTATCANαSrCCATCNO T

GAAGGCCG

TTTNAGCCTATNNGGAGNNGNATNNCAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGTCCGAGTTTTTTTTTTTTTTTTTT^

NTGGNNGCCCCNNAAAANNATGGGNNNCANNGGAANCCCANCCGGGGNCNCCCCNAAA ANGGGGNTNNNCNTNNCCNGGGAANNTNNTTTTTTAAAAAANCCCCNl^ GGAAANCCCNAGGNTNAAANCNAAA(^GGAAANCCNTGGGCNNNGGNNGNTTNCNGGG GGCCCGGNTGGGGNATTGGGNGGNAAANCNTNNGNNGGGCCCGGGTNNCCCATTTNANC CCCAGGNNNTTTNGNANGAANAAAATTNGNCCCCTNCNTTNGANGGGGGNCNANTNTGG GCNGGC^CCaSINCCAGGGNTGGGGGNCNNNNCCCGNAAANAAANNCNGGGNNGGCCNGG GGGGNAGNGCCTTTTNGGTTNAAAAAACCTNTCT^^

GCCαvπSTGGCNNNACCCCNANCNTNGGGGGGGGNCCCCCTCCNGGNCCCGGGGAAAANGG TTTTCCCAAANN<_^TTCCCCCNTTGTNGN^

CCCTTNTTTTT<^CCAAANANGGNNGNTTCCC^

CCCCTCTTTTAAGGGGCCCTATNTTANAGACNGGGGGGGCCCCCANNCCCCCCCNGNGGN TTTTTTTGNGGNNGAANNNCCCCCTTTGGNCCCC(^CGNNGGGNGGNCCCTTTπ NCCACCCCCCCCCCNNGCCTTNTNTTNCCCCCCCCAAAATTTTTTTTNACCNNAACCCCCC

CCCCCCCGGGGGGGG

TTNANAAAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGGAGTTCTGGAGCCAGTATCGGATCAATGTGACTGAAGTGAACCCCCTGGGGG

CCAGCACCCGCCTGCTGGATGTGAGCTTGCANAGCATNTTGCGCCCTGACCCGCCCCAGG GCCTGCGGGTANAGTCAGTGCCTGGCTATCCTCGCCGCCTGCGTGCTANCTGGACNTACCN TGCNTCCTGGCCCCGCCAGCCCCANTTCNTGNTCAAGTTCCGTTTGNAGNNCCGTCCAGCA CAGNNTCCAGCNTGNTNTACGGTGGACCCAGNTGGATTGAAGGAGGTNATNACCGATGNT GNGGTTGGCNTGCCCNATGTANGGCGGGTCACCGCCCGGAACTTTTTGGATGNTGGAACC

TGAAGNTCNTGAANCCCCAAGGCNTGGGGAANTCCAAGCANTGACCCCTTACNNAAGGA AATNCCANTTGGGGACCANCACCCNCACNCAGACGGAGGAAAAACTTTTGGGCANACAG CCCCCGNTCCCCNAAAGCCGTTCNTTTTTACCCANACCCAAAGCCANTTTGACCANAAAA AACCCCCTTGGAACAAGGGGCCCGCCCCTNGCTATTTTTNGGAAAm^ AAACTGGGGGCTGGGGNCCCCTGGCNTTTGGGGCNTTTTGGTTTAAGGGGTTGAAACCCA

NAGGGGGNANAACTNTTTCNCAGGAANNCCCCAAACCCTTTNAAAANAACCNTTGGGGG GCCCTTTITATNNTNTTTTNCCCCCCCAAANNNNGNGGGGGGGGGGGGGGGGGGGAAAA ANAAAAANCCCCGGGGGGGGAAAAANAAANNNCCCCTNGGGGGGGGGGGTTTTTAAAAA GGGNAAAAATTTTTTTTGGAANNCCCTTTTTTTTTN^

AACAAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCACGGCTTTTCCCCCCTCTGACATCGTCTGGGGTCCTGATTCT GTCCTCGTCTCTTTGAAAGCCCTCTGATGAAACAACGGCCCCATCCCTCCCCTACAAGGGT

TTCCATTΓCCCCCAAGTCGTCTATGCATTTCTCTCACCGTTTTCTGCCTCATTCCTAGAGAA AACGGGCATCTCATGTTCCACCCTCTGAGACCCCCCCTTTCAGAAAATGCTGTGCATTTTG GAGACGTGAGGATTTCGTCCAAAGTTCTGAAAGCATTTGCGGAGAGCTCGTTAGAAAATA AAAATGGGAAAAAGCAAAACGAAAAGGCGGTGTCCCCCCACGTCCCTTTCCACTGAGTAA GACCTAGCTCTTTGCGATTGTGCAATAAACTACTTGCCGTGAGAGCAGGTGGCCACGCTCC

TGCCCAGACTACTAACTGACACAGCACANGACGGCGGGCTGCACGGGGGCCTCTCCCAAA CGCCTNCCATGAGCTCAGCTTCCCCCACCACCACCACCAAGCACCGTGTCTTGGCGGNGTC TTTACATTTTAACAAGTATTTTATATTTTCTGNAACCGCACTAAGTCTTAAGGGGTTTTAAA AGCTTCGGTTGGTTCATACTCACAATCAAAACTTTTTTTTTTTT^ NCCCCANTTGGCCCAAAAAAAAAAAAGCCTTTTTTTTTTTGNCCAAAAANACTT^

AAAACCCTTTTTGNGGGGGGGGGTGGGNNCCCCTTTCCCGGGNAANAAATTGGGGNNNNT NGGCATTΓTGGGGCCCCCGGCCCCGGGGAAAAANAAAAAAACCTTTTCCCCCCCCTGGGN NTSINGGGGGGGGGGGGGAAAANCCCCCGGGGNCCCCTTTTTTGGNNNTTGGGTNAANCCC

AAAANAN

NAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCAAGTGCGGGGGCCGCCACGGCAGCCTCCCCAGGGGCAGCCCTTGCAGGGCGGCA TGCTGGCCTCCTTACGCCAGAGCGGCTCCGACCTGGCCTACAAGCTGTGCCACAATGAGT GGGTAGTGGTGCAGAGCTCCACGCACCTGGTGGACGTGGCTGGCTGCGCTGTGGACGTGC

AGCTGCTCGAGGACTCCCACCAGGTGAGCAAAGACGGCTGCAGCTGCAGCTGCTACTTTC AGCAGCGGTACCACCTGCCGTGCCGGCACATCCTGGCGCTGCTGCACACCAGCCAGAGGC CTGTGAGCGAAGCCATGGTGTGCCGCCGGTGGCAGAAGAGGTACCAGCACCTCCTCGGGC CCTGCGGGGAGCTCCGGGACCCCATTCTGATCCCAGCAGATGCAGGCCAGCCAGGGGAAC CGGGACGGAACGACATGATTCAGGACCTAAGCAGGGAGCTTGCAAATCTGCTGATGCAGA GTGAGGGACCAGAGCTGGAGGAGCGCTGCTCCACGCTGCGCAAGATTGTGGACATTNTGG GCGGNCCCCCGCCAGCCTTCTGAGCCCAGTCACCAANCCGANGGAATTTCANGGATGTGG GCTTGNCTNCCTTTTCTTNTGGGGAAAGCANGAAGGAAGGGGANGGACTGGCTTCTTGCT GGCACCCACCATTTCATGGTTGAAACCCCTTTGCCCTTGGCATTGCTTAGGNCGGCAAGCC

CCNTTTTC(^TTACAGNCCNAANAAACTTNAAAGGGGGGCCANGAAATTTGCCTCGGGGG TCAGGGTTTTAAANCAAAGGTNTTTTTTTO^

AAAAAAAAAAAAANCCCCTTTTGGGGGGGAAAANCCCNTTTNAAAATNGGNCCCCNNTTT TTGGNCCCGGGGTTTT

AAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGGAAAAAAAGAGAAAAAATTTAAAATAAAAAAAAAGAAAGAAACCTCCAACGTATTTT ATCACTACCTATAGGAAGAAATCCTGCTTTGAGAGTATTTGTAATGCGGTTTTGTTGTCGT TTGTTGCTGCTTATTTCACTAAGAAAAACCCAACAACTGAGACTGCCTAGCCCGCCGGTCC

TGTGCGCTTTTATTGTGCTTCTAACCCCAGTAGAGTAGAACTAAATTGCACTGAATGTATA GTTAACTGTCTTGAATCCTCTGTTTATGCAATGTGCTCGAAAGAAAAACAACGTTAAAAAT ATATCTATAATAATAATTTTTGGTCATTCGTCTTTATGTCCAGCTATGAATGTAGATTTTGT GTCCCGGCAGCAGCTCTGTTTCTGGTCGAAGTACTTTGTATTGTATACCGTGAGTCATAAT AAAAAAAAAAAAAAAAANCTNGGGGGGGGGCCNGGNCCCCANTNCCCCNTATNGGGAGC

GGTTTANANNNNNNNNNNNNNNNNNNNΓΠW^^

NNNNNNNNNTSINNNNNNNNNNNNNN^ NNNNN lNNNNNNNNNNlS^^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNTWNTSΠSΓNNNNNNNNNNNNNNNNN^

AAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GCGTGGGTAGAGCGCCTGAAGGCCTCAGGGACGCTTCGAGAGTATAAGGTGGTGGGGCG CTGCCTGCCGACCCCCAAATGCCACACGCCACCCCTCTATCGCATGAGAATTTTTGCGCCT AATCATGTTGTTGCCAAGTCCCGCTTCTGGTACTTTGTGTCTCAGTTGAAGAAGATGAAGA AATCCTCGGGGGAAATTGTCTACTGTGGACAGGTGTTCGAGAAATCCCCCCTGCGAGTGA AGAACTTCGGCATCTGGCTGCGCTATGACTCCCGCAGCGGCACCCACAACATGTACCGGG

AGTACCGGGATCTGACCACTGCCGGCGCCGTCACCCAGTGCTACCGAGACATGGGCGCCC GGCACCGAGCCCGGGCCCACTCAATCCAGATCATGAAGGTGGAGGAGATCGCAGCCAGC AAGTGCCGCCGACCCGCGGTCAAGCAGTTCCACGACTCCAAGATCAAGTTCCCACTGCCC CACCGGGTCCTCCGTCGCCAGCACAAGCCACGCTTCACCACCAAGAGGCCCAACACCTTC TTTTANGTTCAGGCCCTCTGTCCCCAGGGCTGCACAAATAAAACTTAGTGGGAAAACTGN

NNNNNNNNN MSINNNNN^

TCCCCTTTTANNNGGGGNNNNNNTNNANANNNNNNNNNNN^ NNNNNNNNNNNNNNNISINNN^ NNNNNNNNNNNNNNNNNNNNNNNNTS^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

GCCTATANNGAGNNGNATNACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGCTGCGAANGCCAGGGAGTTCAAAGAATGCGTGGAGTGCTTCGAACGCTCTCTGAAG

ATTAATCCCATGCAGCTCGGAGTGTGGTTTTCTCTGGGCTGTGCCTATCTGGCCTTGGAAN ACTACGGAGGTTCAGCGAGGGCATTTCAGCGGTGTGTGACTCTGGAACCCGACAATGCTG AAGCTTGGAACAATTTATCAACTTCTTATATCCGCTTAAAACAAAAAGTAAAAGCTTTTAA AACATTACAAGAAGCCCTCAAGTGCAACTATGAACATTGGCAGATCTGGGAAAACTACAT TCTCACTAACACTGATGGTGGAGAATTTTNTGANGCCATTAAAGNTTATCATCGGCTCGTT

GTNCCTACGANACNACTACGATGNTCCNGTNNTTNNNAANCTTGNTNGGGNCNGNCGANT GATNGNNATGGACCNGNCCGATNTGGCTNAGNANGAACCCGNCCTCNNCAAAGAAAGNT NCCAGGAGNTNNTTTNGNNNAGTGTCTTTCNCNTAACTGGNNNNNNGNNGGGGAAANTC ACGGNNGGG(_^GTTNGNCTGCTTCANATTNGAAANGGCCCCNGGGNTNANTNACCCTCCN TGANATAAAAAAGGGGNACNCCCCTTNCANTNTCTTANTGNNANNCATNGGNNGNCCCN

ACCCCCCATNTTTNGGGGGAAAAAAAAAATAACTNTTTTTTTNATNTAAGGGNNNNANAN

ANCσSTTANCC(^TTCGCACCNNTGGGCTTTTTAATTTNA NAAAAANAAAAATCC(^

C(^GGGGGCCTTTTAAANATATNCGNGTTTCCAGNNNC^

TNNTTTTTTATAACANAAAAAAOSINTTT^

NNCGNCGAGTATTNTTATGNTCNAAAAAAAACOSTTO^

NNNNTNTNNAATANTTCTTCNTNCNCTNTTCTCANCANNCCT

NCANNANCTGGAGCTNCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT

GCAGGTAGTAAACCCAAGCCCTTGACCTCTTACAGGGAGCTTTGGTCTGGCCCTTCTTAAT AACNNTCCGGGCCCNANCNTGGGNATTNAACTTTNANCTTNANGGNCCNGGTTANNANTG GNC⁽^ACCACCAANNTTNNNACCATNNNNCNANGGAGNNCAAAAGGTNNTCNNAAAANN NCCNTTCNAGGGNNCCNTNCCCCANCTGGCCNAAAAGGGCNTCGGTATGGNANAANTCTT TTTANTANNTN(^AAGNA(^ANTCTTTANCGGANTTTTCTNNANNTTT^

NTGGCCCCAACCCTNGACNATAGGNGGTNGNNNACCCCAACANGGCTTCTCACCACATAT AACCCCCTATANAAGTCCACATGNGCACACACACTCTGTGTCTATATGNGNCTTCGGNGA GTTCTATANACACTGAGNCCNNATATATANTATNATANAGGGANACGCGAGCGNATATAN CACNCGCNNTNTNTANCNNNATCANNTTGAGAGTANNNTNCACTNTNNNACNNNNCTGA AAAOsπSlTNNNANACNNNTTNCTATATCCNACGGAGGANTACANGNCATCATNTTTTTGTA

NACACAGGGGTTCACGGCGNTCTCGACGNTCATNTGGGGGCACCNNTCTTTAATAAGTGN GCTGCTTCCCGCCGACAAAAAAAAATATTTTACTTCTTAACCACCACTTCTGCTNTTAAGA CGCNGGCCNGATGNTGNCGTTNTTNTAGACGANGTAGGGACGATTTCCTCCATGATGCTA TCTATTGANGANGNGGGCTTNAANAANNNNAAAANN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNNN^

TGAGNCCNTNANNGNNTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG NTNCTNNTCCNAAAAANNAATNGGNTNCATNGCTNCCCNAANCGGNNGTCNΠ^CCAAAAA

NGCGNATGTNCTTNGNAAGGGNNAACTTNTNNTANAAAAACCCCHNNGNGGTNGGNAGG

GNNGACCCAAAGGNNANAAACAAACTNGTANGGCCNNGNCNTCGGGNNGNTNCCCGGTT TCANGNTTNGNGAANNTGGNATNAAACCTNCNGNCCTTCCNANTTNTGCCNNTNTGAACN OSINGGGGATTTGNGGAGAGANNCCCACNNGA(^GTTTNTTTNNNAGNANNGNCAA NGNGCGACANNTNTA⁽^ATGTNGAAANNCCAANACTTCTNATACNNNNCCCTTTTNTCCC

TGAANGGGAGAATAAGGGCNTTTCTTTGTGGNANAAANACCCTNATAAAGCNCCCTGGGA CNCAATGTTNTGGNNCCCTGGNCCNNCNGCACAAAAANTTNNANNGGNNTANCNNNTCCT NNTNCCCANANTCNTANAGGGAATTTCNTTAAAAATNTCTGNNNCTNAANTNNTTCNCAA AGTTNTT] AAANATGNCAGNCNNA<^GTTA^ TTTGGNCCNNNN⁽^CNNGNGTATAAANTTCGTGNANNNCNGNGNANCAAGTTTTTT^

CACNNCNNNNATTATATATNGGNGNGGGCNNANTCCNTTTCNCNGNNANCTTNTNNAGNN NGTTTNACTCACTNNTAACCNNNNGTCNNGNTNGTCCTCTTTATGNCANANNCAAAATCT CCNA⁽^CTTCGCTTGAATTCNACCNNAAACCTTTTNCCTNCAAATTNCCTAATNCTCNTGG TTNTNTCACTANAATAACATNNNNANAAANNNNCTCNCGNTTTTATCANO CCATCNCNT GAAGGCCG

TGAGNCCNTNANNGNNTCGTATTACAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGN(^AGTNNTNGTTTTNTTTT^ NTNCTNNTCCNAAAAANNAATNGGNTNCATNGCTNCCCNAANCGGNNGTCMSICCAAAAA

NGCGNATGTNCTTNGNAAGGGNNAACTTNTNNTANAAAAACCCOWNGNGGTNGGNAGG GNNGACCCAAAGGNNANAAACAAACTNGTANGGCCNNGNCNTCGGGNNGNTNCCCGGTT TCANGNTTNGNGAANΗTGGNATNAAACCTN(^GNCCTTCCNANTTNTGCCN[NTNTGAA(^ CNNGGGGATTTGNGGAGAGANNCCCACNNGA(^GTTTNTTTNNNAGNAN^ NGNGCGACANNTNTAt^ATGTNGAAANNCCAANACTTCTNATAOWNNCCCTTTTNTCCC

TGAANGGGAGAATAAGGG⁽^TTTCTTTGTGGNANAAANACCCTNATAAAGCNCCCTGGGA (^CAATGTTNTGGNNCCCTGGNC(-MSrαS[GCACAAAAANTTNNANNGGNNTANC NNTNCCCANANTCNTANAGGGAATTTCNTTAAAAATNTCTGNNNCTNAANTNNTTCNCAA AGTTNTTTTAAANATGNCAGNOSENACNGTTAANNCNCTCGCCTTNT^ TTTGGNCCNNNN<^OSπsrGNGTATA^ CACNNCNNNNATTATATATNGGNGNGGGO^

NGTTTNACTCACTNNTAACCWNNNGTCNNGNTNGTCCTCTTTATGNCANANNCAAAATCT CCNA(^CTTCGCTTGAATT(^ACαvlNAAACCTTTTNCCTNCAAATTNCCT^

TTNTNTCACTANAATAACATJNINNNANAAANN^ GAAGGCCG

TTNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCACGAGGCTCTCTTTAGTTCTTTGTACGGAGGTGAAAAAAATAA AAAGATCCTTCAAAAATGGCAATGGTATCTGAATTCCTCAAGCAGGCCTGGTTTATTGAA AATGAANAGCAGGANTNCNTTAAAACGGTGAANGGATCCAANGGNGGTCCTGGGTCAGC AGNGANCCCNTATCCTACGTTCANTCCNTCCTCGGATGTTGAGGCCTTGCNCAAAGCANTC ACAGTTAAAGGNGNGGATNAANCACCCNTCNTTGAANTTNTGACTAAAANAACCANTGC

ACAGNGTCAGCAAATCAAANCGGCCTATCTGCAGGANAAAGGAANGCCCCTGNNTNAAG TNNTGAANAAGGCCNTCNTCGGNCACCTTGAGGANGTNGTTTTGNNTNTATGGAAANCTC CANCCCANTTNGATGCCNAAAAGCTCCGCGCTGCNNTGAAGGGCCTTGGAACTGATNAAA ACCCTNTGAATGAAATTTTTGNCTTCGAGAACTTCCCAGAGAGATCAGAGAATTTANCAG AGTCTNTAGAAAAAAACTGAAGAAAGATNTGGCTAAAANACATCGCCTTAAACCCATTTG

GANAATTTGAAAAGGNTTTTGTTTGCTNTTTCTTANGGGGGACCCGACCCCAGGGACTTTG

AAAAAAAAAΛGGGGCCCAANNGGGAAANNGGTTNCAATTACCTTTTTTTAACCCCCNGGG GGNTTTTNCCOSTTTTTTCGGGNAANGGGT CTTTNNNTTTAANANAANTTTTTTTGNCCCCCGGGGTTTNAAAAGGGGGCCCCCT^

AANNCN

TNNAACAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGNTATGAAGCTTATCNATACCGTCCACCTCTANGGGGGGCCCGGTAC

CCANTGNNCCCTATANTGANNCACATTACAGCCCGGAGGAATGGTAGATGGCANGTGTTC TTGTTTTTAACCAATATGAGGGATGTCCTGAATTTGGTAGAACAACTGTGAGACAACTTCA GCAAGCTTTGTAAACAGGTTTTATATTCAGTTTGGGGGTAATGAAGCATTTCAGTTTCGTG AGTAGAGGGCCTACTTTTCTTTCCTCACCCTGTATTTTAAAAGTCTTCTAAATATGTAGTTT CGGTGTATAATTCTGGGCGGGGGGAGTTTTTTTGGGGGGGGAGCAAAΛTATGTTTTGAGTT

CTTTTCCCTTTAGGTCTGTCTAGAATTCCAAAGGCAAATGACTCGAGGTAACAGGCGAAA AGAAAATCCAATATCAGGATAATCAGAACACTGCAGGTTTACAGTTATAGAAACTCTAGC ACAAGCAGCTTTCACTTTGANGTCTGTGGCGCAACTTGTCCATTGGAAGTAATGGCTGGTA AGTTTATTCTTTTTTTCCCCACCCCTTTATTAAAATATTTTTATAAAGGACCGTA^ ATITTTACTTAAATANTTTTGGGGGGGGNGNGAACANGGAAAAANGGGGGGGGGAAAAA

CTTTTTTTTTTTTAAAAATTTTCCCCC^^

AAAAAAAAGGAATGGNCTTGTTACCTGGTTNGCACCAACANCCTTTANGGGATNGGACCA NTTTTTTTCNTTGGGAAAAAATNTTTCCCANNNGAAACCTGNAAAGGGCCNCNCCCCAGG GCNΠ GTTTTGGGTNATTTTTCNNN^^

TNNAACAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGAATTCGNTATGAAGCTTATCNATACCGTCCACCTCTANGGGGGGCCCGGTAC CCANTGNNCCCTATANTGANNCACATTACAGCCCGGAGGAATGGTAGATGGCANGTGTTC TTGTTTTTAACCAATATGAGGGATGTCCTGAATTTGGTAGAACAACTGTGAGACAACTTCA

GCAAGCTTTGTAAACAGGTTTTATATTCAGTTTGGGGGTAATGAAGCATTTCAGTTTCGTG AGTAGAGGGCCTACTTTTCTTTCCTCACCCTGTATTTTAAAAGTCTTCTAAATATGTAGTTT CGGTGTATAATTCTGGGCGGGGGGAGTTTTTTTGGGGGGGGAGCAAAATATGTTTTGAGTT CTTTTCCCTTTAGGTCTGTCTAGAATTCCAAAGGCAAATGACTCGAGGTAACAGGCGAAA AGAAAATCCAATATCAGGATAATCAGAACACTGCAGGTTTACAGTTATAGAAACTCTAGC

ACAAGCAGCTTTCACTTTGANGTCTGTGGCGCAACTTGTCCATTGGAAGTAATGGCTGGTA AGTTTATTCTTTTTTTCCCCACCCCTTTATTAAAATATTT^ ATTTTTACTTAAATANTTTTGGGGGGGGNGNGAACANGGAAAAANGGGGGGGGGAAAAA CTTTTTTTTTTTTAAAAATT^ AAAAAAAAGGAATGGNCTTGTTACCTGGTTNGCACCAACANCCTTTANGGGATNGGACCA

NTTTTTTTCWTTGGGAAAAAATNTTTCCCANNNGAAACCTGNAAAGGGCCNCNCCCCAGG

GC^WCTTTTGGGTNATTTTTCNNNCNTTTTNAGGGAAAAACTT^

TTNNNNAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTNGANNTGANGCTTATCGATACCNTCCACCTCNANGGGGNGCCCGGTN CCCAATNCNNCCTATANNGANNCNNATTACAGCCCGNAGGAATGGTAGCATGGCANGTGT TCTTGTTΠ AACCAATATGAGGGATGCCCTGAATTTGGTAGAACAACTGTGAGACAACTT CAGCAAGCTTTGTAAACAGGTTTTATATTCAGTTTGGGGGTAATGAAGCATTTCAGTTTCG

TGAGTAGAGGGCCTACTTTTCTTTCCTCACCCTGTATTTTAAAAGTCTTCTAAATATGTAAG

GTTCTTTTCCCTTTAGGTCTGNCTAGAATNCCAAAGGCAAATGACTCGAGGTAACAGGCG

AAAAGAAAATCCAATNTCAGGATAATCANAACACTGCAGGTTTACAGTTATAGAAACTCT AGCACAAGCAGCTTTCACTTTGAGGTCTGTGGCGCANCTGTCCATTGGAGNAATGGCTGG

NAGTTTATTNTTTTTTTCCCCACCCCTTTATTAAATATTTT^

TAATTTCAACTTAAATATTTNGGGGGGGGGGGNAACAGGGAAAAAGGGTGGGGGAAAAA

ACTTTTTTTTTTTTAAAAATTTCCCCCAGAATTTTΠ

AAAAAAAGGAATGGAAATGGCTAACCTGGTNGGGAACCAAC(^CCTTTAGGGANTGGAA AACCCTTTTTTTTNTTGGGAAAAGGTTTTCCCAAAAGGAGNTCNAAAGGAACAA^

NGCCGGGNTTGGGGNNCCTTTTAAACCCTTCCCCAAGNAAAACCCTCNNAAATTGGT

TTGANAAANCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCTTATNTNAANCGTTNGANNGNAGGTGGCNCCCNNTAAA

ATNTNCTTCANATATTGNANαSfTNTTNNGNATNCCTCATNNATGCNTGGTTGATTGAANA NGNGNNATACTAATTAATNTGGACNGGNAGGGNNTNCANANGAGNTNCTNTATCATCAG CAAGCCNATAANNTANGATCAATNTATNNTCNTATGTNGCNGCNTTGCTCATGGTATTCA NAATNAAANNCNNGCACNATGCNANCGTGGNTTGNANNCNTGACTAATGAAANACAGAT GCACANCGNCACGNTATGAATACTGCTTNTCNGGAGGATAACGGAANGNACGNTGGATA

ATAANGATTAAGAAGGOSπSINT⁽^AGATGATNTTGNGGANTTTGNTTTGGCTCTNTNGAAN ACTGCTCCCCAGNTAGATNNCCNATNGNTACGTGNTGACTTGANTGGCCTTCAGACTGAC GNGGACNCTGTGANNGATNNTNTNCCATATGNAACTNTCAGAACTANCANGANAAATTAT CCNGGGTCTCTCTANAATNACTGANTACAGGANCTNGATNNAAGA⁽_^TTTGCTCANNCNC ATTTTGGTTTATTATGNTAAAGGATTTTGCTTGCTCTTTCTTATGNNTGACCGNATATGANG

GACTTCANTGTATAATGGAAAAACTTGNTTGATTTTGACCCCAGGGCCTTATATTNAAGCC NGNGGGAATCAAAAAANTNNNGGTTCNAAATTTTAAATGGGGTTCNCCTTACAANTTTTT TCCNCTTGGGACTTTTTNCCCATTTCCCGNAAA^ NTTTNGNNNGGCTTTNCCTTTTNAACNANNNNNNCTGGGN

TNNANCNNNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCCTTGGTGTCCGAGCACTCTCTCCCTCTCTCTAGGGCGGCGACCTCCGGCGG CCGGAAAGTCACCATGTCCATCCTGAAGGTCCACGCCAGAGAGATCTTTGACTCTCGTGG GAATCCCACCGTTGAGGTTGATCTCTTCACCGCGAAAGGTCTCTTCAGAGCTGCTGTGCCC

AGTGGCGCTTCAACTGGAATCTATGAGGCCCTGGAGCTCCGGGACAATGATAAGACGCGC TACATGGGGAAAGGTGTCTCAAAGGCTGTTGAGCACATCAATAAAACTATTGCGCCTGCC CTGGTTAGCAAGAAGCTGAACGTCGTGGAGCAGGAGAAGATCGACAAGCTGATGATAGA GATGGATGGCACAGAAAATAAGTCCAAGTTTGGTGCGAACGCCATCCTGGGCGTGTCCCT GGCTGTCTGCAAGGCTGGTGCTGTGGAGAAGGGGGTGCCCCTCTACCGCCACATCGCCGA

CTTGGCTGGCAATGCTGAGGTCATCCTGCCAGTTCCGGCTTTCAATGTCATCAACGGTGGC TCTCATGCTGGCAACAAGCTGGCCATGCAGGAGTTTATGATCCTTCCTGTTGGGGCCCGAA AACTTCCGGGAGGCCATGCGCATCGGANCCAGAAGGTTTACCACAACCTGAAGAATGTCA TCAAAGGAAAAAATATGGGGAAGGATGCCACCAACCGTGGGAGATGAAGGGCGGCTTTT GCCCCCAACATTCCTGGANGAACAAANAANCCCTTGGAGCTGCTTGAANAATGCCNNTCG

GCAANGGCTGGCTACCANCNGACAAAGGCCTTCATTCGGGCATTGGACGTAACTTGCCCT NTGAGTTNTANAGGTCCGGGCAAGTNTTGAACCTGGACTTTAAAGTCCCCCGATGACCCC ACNNGGTTCATTCACAACCCGNAGAAGCTGGGCCCACCCTGTNCAATTCCTTNN NNTATCTGGAGCTCCACCGCNGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCGGGCTG CAGGAATTCCGCCCCGAGGGCAGTGGACTGCNNTCGCCACCTTCCTCTATGCGGAGGTCTT CGCTGNGCTGCTGCTCTGCNTTCCCTTCATTTCTCCCAAAAAATGGCAAANNATTTTNAAG TCCCNCCTTGTGGAGTCGGTATGGACATATGGCACCACCTTCTTTGGGGCTCTCATTGNCA

NCCTTGNGCTACAGNACATTGATGCTGTTCGNGAGATTNAAANNTATGATGATGNGACAN ANAAGGNGAACCTNCANAAOSINCCCTGGGGCTGNGGAGCACTTCCACATNAAGCTTTNCC GTGCCCAGAGGAACCTNTACATTGNTGGNTTTNCCTTGCTGCTGCCCTTTCTGNNTANACG CCTGGNGACTCTCATCNCCCACCAGGN(^CGCTGTTGGGCTGCAANAAANNNTTTAAAAA GCCGGCANAGAGCGCCAATGNTGCNTCCAAGACCTTGNATGGAGGANNAACCACCTCCN

CAAAGANTGNTNCTGGNGGGAACCACCTTNTTGGGGTGGGGACCNCCACTGAAATNGCCC CGGGAATAAAAAAAGANNCNTNANGNTTTTTTTCAAAAAANCCANAAO NAAAGGNTGG NGTTTTACCTTTNCAAAGGNGGGAAAANGGNGGGAAAANNNAAAATO^ CAACαsfNTTTTAAGGGGCTTTNCCANGNGGAANTNANACCCCCTGTTTNGGGGGNANACN NCTAAATTTNGNGAGNNTTNCNTAANTGGGGCCCCCNNGGCCCANAAAAAAANAAATNA

NCNTTTCCCCCNCCCNTTNTTGNGNCN^^ ACCCCCCCTATNTNTTTGGGCGNTTTTTTNTTCTNANNGGGGGGGGGGNGGCNCCNCCNTG

TCGGCNNNGGGGNGNGCNNCNGNGTCCTNAACTCCGCTNNCNANAGCNANATNTGGAGC NCCACCNCGGNGGCGGCCGCGTCTAGAACTANTGGANCNCCNCGGGCTGCACGNAATNN GGCNCNAGNNNTTIKNCCTATTACAGGNCTAACANACACGNNNNACCCNGGGGGNCNCN

TGCTC(^(^TNNNACTTNNCNTN(^TTNNNαWTAAT^ ANNANNNNCCNNCGNCNCTCAAACTCNTNTTTTACCNTNGTTNTNGCNATCCAATCGNNN

GCTCGGCGCTGNNGNGNNNATGNNGTAGTTNNNACM^GCTANAAGNNAGTNANTTNTTN NTNNNTTNNNNTTGTNTNNAGCNGCGNACCGNN^

ACTTCCNATTGTNGNNACTCTANNCCTNTNNGTGTAGACCTNTANNNCTNATTCTNTATNT NNNGNNGNNCNANGNAGTTCATNTNTTTNTTGTNNAM fGTNNCNCGNr^ NTTTATTNATTTACTNTATGCTGTNGNGN^

GNNTANNTNNNTGANTGTNTTANTANTNTNNNANCGTGNNTNATGNNNGNTCTCCNNNNN NNGNNTTCGANGCGNAAGGNGCCGNNNNCNTNNAACCACTTTANGNAGCNNACGTGTNA ACNT1SINTCNATGT(^TNNNAGNC(^GCNNCGNNGNNNNTTCGNNTCCNNTNCGCTTGNN^ GNNNNTNNANCTATNNT<^T1S!NNGN^ CCCCCCCCTNNCTOSINACNNTCTCNNTATCCNCTGCTCNCNCANNGNNAACTAGNTNNTA

NCATTGTATNN(3NTCGNATNNTANTTCACCANNGCATGANTTCGCCTNTNANTCGTNTNAT AAATNNNANNACNNCCNATTGNATTACTANATCACNGCTTTNTTAANTGNTCNNCGNANN NGCNNGCATCTGNGCTTNNCGATNCNCANTTNCNTGTGAGNNGNGANNGACCGTATNNA NTNTNNNNNCNTCTNNCGNNANNN(^GCNCNTACTTNNNCCNCTCTGNTCTCTAGNACNT GA⁽^ANTTGN(^ANCNTOSlNNNCCACTCNGNNGANTANACACNGNGNTTCTCTTAATCTC

TAATNCGGGACGGAAGGGNCTCCCNCTACGNGGATNNNGTNGTGANTNTAANCNNNGCT GTNGATANNNTCGCCCCCCCCCCCCCCCCCCTCTNTTANTTCNACTTNNTGTGTGTNTACN ATNAAGCNAANTCTATNCTCTNCTCNCCTCCGTGTGGGGGGNGGCNNTCNCCC

TTGANNANANANGGAGCTGCNCNCAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCANGNNNGAGNCCNNNTNGTATTTTTATNNAANNGNCGGTO NCNANTTGGGGGG GNATATNGNA^CAACANAATATNNGANNNCGTTN^ CAAAGGGGGNGNNCC(^CCTNGCNAGGGNCNTNNTTGTATTAATAAAAAACGCAGGNAG NTNGGACNNNNTANNCCTANCGNANANANNTCNTNACTCGGNAACCNTAANNNTGNACA

GNTCAGGNGNATTNNTAGNNCTGNNANTNCNTGGNANNANNCANANNNTAAANTNCCNN NNGNMSπsπSfNGlSINN^

NAGAGNCNMslTGACNCNNGNNTTNCTATNTATNNGNGNTGTGNANANATGNGAGACGNG NNCATNGNGAN[NGGGTNANACNGGT INA^ (-^ANGNTTTNGANNAAGCCATANTCCNNNNCAC^TACCANCCTTNCTACAANNTNAATAC

GNCNTGCCANAACTNNOWGGANTNNNNTNNGG(^CNAANCCCNCNANACNANCCCGGN TTANGGTTNNATANGGGCTCGNGGNA(^GNTNTAAJS[TTATAATNATTTACTNAAAGACAC CAGTNNN(^ATNGACNNGTGNTCACGNNNAGTNGGNTGANNGTTNNTNANTNCGNCAGA TCαSlNNTNTTNCGANAANNACTANGAGATNAGGNGAGTNGα^CCNGGGGNTTCAAANTT TGGATGTTTNGGCNAGACGATNNTNTNTN<^^

NGGANNNGGCACNCTTGTNTANNGTNATNNCTANNAGTAGTGAAGACNNCGTCACNTAG

ANTANGATTGGANGNGATNNTNCTCANTATGAGAGTAGACAATGNANNGNCANGANGNT

TN( NGTTTANNTAGNGGNTANTNNNNNOSπsπS[TNTGAGANTNNTNAGNACT^

GTANISINANTGCTTATGCCNCNAAACAANAACNTGGNNCTGAGANTGGNCNTGGNGGNNT

CNTNNTGAANTAATACGCAGGAAGANCCG

TTGANNANANANGGAGCTGCNCNCAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCANGNNNGAGNCCMSENTNGTATTT^

GNATATNGNACNCAACANAATATNNGANNNCGTTNNAAAN(^TANCNATGTNTTGTTCTC CAAAGGGGGNGNNCCCNCCTNGαsrAGGGNCNTNNTTGTATTAATAAAAAACGCAGGNAG NTNGGACNNNNTANNCCTANCGNANANANNTCNTNACTCGGNAACCNTAANNNTGNACA GNTCAGGNGNATTNNTAGNNCTGNNANTN(^TGGNANNANNCANANNNTAAANTNCCNN NNGNNNNNNGNNNGTNTTTNNCT^

NAGAGNCNNNTGA(^αSINGNNTTNCTATNTATNNGNGNTGTGNANANATGNGAGACGNG NNCATNGNGANNGGGTNANA(^GGTNNAATTNNOS[TTTCCNANGACNANNCCTNCCNGC CNANGNTTTNGANNAAGCCATANTCCNNNNCACNTACCANCCTTNCTACAANNTNAATAC GNCNTGCCANAACT πsrαSINGGANTNNNNTNNGGCNCNAANCCCN(^ANACNANCCCGGN TTANGGTTNNATANGGGCTCGNGGNACNGNTNTAANTTATAATNATTTACTNAAAGACAC

CAGTNNN(^ATNGACNNGTGNTCACGNTS1NAGTNGGNTGANNGTTNNTNANTNCGNCAGA TCCNNNTNTTNCGANAANNACTANGAGATNAGGNGAGTNGCNCCNGGGGNTTCAAANTT TGGATGTTTNGGCNAGACGATNNTNTNTNCNGGNGACANACTATNNTACTNGTNGTGNCN NGGANNNGGCACNCTTGTNTANNGTNATNNCTANNAGTAGTGAAGACNNCGTCACNTAG ANTANGATTGGANGNGATNNTNCTCANTATGAGAGTAGACAATGNANNGNCANGANGNT

TNCNGTTTANNTAGNGGNTANTNNNNNOSINNTNTGAGANTNNTNAGNACTCGNNAGC GTANNNANTGCTTATGCCNCNAAACAANAACNTGGNNCTGAGANTGGNCNTGGNGGNNT CNTNNTGAANTAATACGCAGGAAGANCCG

TTNNNNAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGCAGGATCAAGCGATTCCTGGCCAAGAAACAAAAGCAGAATCGTCCCATTCCT

CAATGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACNTTG

GANAANANCCAAGCTGGGTCTATAAAAANCANGCTGGGTCTATGAAAAGNGGTCTTANC ATGTAAACCANTTTTTTAANCAGCCANATCNCANNGAAANCNTCNNTACNGTANNGCTNG

GCCCANGANGTNNTTTC TNNNTNTCAGNCNGNAACCCANCATTAANTNTAAANCGTNGC

AAAAAAAAAAAAAAAAANNTGGGGGGGGGNCCGGGNCCCAATTTCCCCTTNAGGGGGGN

CGTTNAAAAANNNNNNNNNNNNNNNNNNNNNN^

NNNNN(^TTNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNGNNNNNNCNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNΗNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNTN

AACAAAATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGCACGGCAAGTTCAACGGCNCAGTCAAGGCAGAGAACGGGAAGCTCGTCATCAA TGGAAAGGCCATCACCATCTTCCAGGAGCGAGATCCTGCCAACATCAAGTGGGGTGATGC TGGTGCTGAGTATGTGGTGGAGTCCACTGGGGTCTTCACTACCATGGAGAAGGCTGGGGC TCACTTGAAGGGTGGCGCCAAGAGGGTCATCATCTCTGCACCTTCTGCCGATGCCCCCATG

TTTGTGATGGGCGTGAACCACGAGAAGTATAACAACACCCTCAAGATTGTCAGCAATGCC TCCTGCACCACCAACTGCTTGCCCCCCTGCCAAGGTCATCCATGACCACTTTGCATCGTGG AGGGACTTATGACCACTGTCCACGCCATCACTGCCACCCAAAAGACTGTGGATGGCCCCT NCGGGAAGCTTGTGGCCGTGACGGCCGAAGGGCTTGCCAAAATATCATNCCTGCTTCTAC TGGCGCTTGCCANGCCGNGGCAAGGTCATTCCTTAANCTAACGGGAAACTTACTGGCATG

GCCTTCCGCGTCCCCAATTCCNAACGTGTTTGGTTGNGGATCTGANCCTGCCGCCTGGANA

AANCCTGCCAAGTTTGATGANATCAANAAGGNGGTGAAACCAGCGTCAAAAGGCCCTTTN

AANGGCANTTTTAGGCTACCCTGGNGGACCAGGTTGGTTCCTGGGAANTTNAAAAGGGAA

CTTTANTTTTTTNAC(^TTNNAAGCTNGGGGTTGGNATTTGNCCTT

GAAAGCTTATTTTCCTGGGGA(^AAAAAATNAAATTTGGCTTCCCCCAAAAANGGGGGGG

GGGGACCTTTTTGGGGCCCAAATGGGCCCCCCAAAGNGAGNAN

NACAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGTTTTAAATCAAGTCAACCACTTTTCAAAGTAAAGAGTTCACACAACTACTTTCATGA ATTTTTTAATCCCGTTGGAAACATATACCAGGAGTGTTCCAGTATACTGGAATACAGGCAC ACTACCATTCATGGTATGAATTCTGGGGTTTACACAACCAGTTTTGATGCAATCTGCTCAG TAATATAATTTGTCATTTTTATTANAAATATAATTTCTTCATGTGATGTCATGAAATTGTAC ATACTGCAGTGTGAATTTTTTTGTTTTGTTTTTTAATCTT^

TTTGAATAAATGAAGGAAAAAATTCAAAAAAAAAAAAAAAAAACNTGGGGGGGGGNCCN

GGCCC(^ATTNCCCCTTATNGGGNGNNGNTNAAAANNNNNNNNTS[NNNNNN^

NNNNNlSπsfNNNNNNNNNNNNNTSπSINN^

NNNNTSINNNNNNNNNNNNNNNNNNNW NNNNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNl^NNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNW NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNN^

NNNNNNINNNNNNNNNNNNNNNNNNNNN^

TTNANCAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGCAGGATCAAGCGATTCCTGGCCAAGAAACAAAAGCAGAATCGTCCCATTCCTC

AATGGATTCGAATGAAAACTGGCAATAAAATCAGGTACAACTCCAAGAGAAGACATTGG

AGAAGAACCAAGCTGGGTCTATAAGAAGCAAGCTGGGTCTATGAGAAGTGGTCTTAACAT

GTAGACCACTTTTTTAAGCAGCCAGATCACAATGAAAACATCACTACTGTAATGCTTGGCC

CATGATGTTATTTCCTCACTATCAGTCTGAGACCCAGCAATAAATATAAAACGTTGCAAAA AAAAAAAAAAAAACNTGGGGGGGGGNCCGGGNCCCNATTNCCCCNTNTGGGGNGNNGTT

TAACANNNNNNNNNNNNNNGNNNNNNNNNNN^

NNNNNNN M I T^^

NNNNNNGNNNNTNNNTNNNNNNNNNNN^

NANNNCCCCCCNNNNTSINNNNNTNCCCCCCCCNNNNNNNTSIN^ CCMπSI [N CN]NrNN^

NN>JNNGNNNNNNNNNNNNNNNN^

NNNNNI^MNNNNNNNNNNNT QSINNN ^

NNNNNNNINNNNNNNN SfNNNNNNNNNN^

NNNNNN NNNNNNNNNNNNNNNNNNNN^

GCCTATNTGGAGCTGCATCNCNGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTGAATTCCCGTNGANNTTANAGGGAAGCTTTNACAATGNCCGGAGCCCTTGATGTC CTGCNAATGAAGGAGGAGGATGTCCTCAAATTNCNTGNANCAGGAACCCANTTAGGTGGC ACCANCCTTGACTNCCANATGGAACAGTACATNTACAAAAGGAAAAGTGATGGCATCTAC

ATNATAAATCTGAAGAGGACGTGGGAGAAGCTTCTGTNGGCCGTTCGGNCCATTGCNGCC ATTGAAAACCCGGCTGATNTCAGTGTCATATCCTCNAGGAATACTGGCCAGCGAGCTGTG CTGAAGTTTGCTGCTGCCACTGGAGCCACTCCTATCGNTGGCCGCTTCACTCCGGGAACCT TNACTAACCAGATCCAGGCCGNATT(-^GGGANCCAAGGCTTNNGGNGGTCACCGATCCCA NGGCTGACCACCAGNCCCTCACGGAAGCCTCTTACNTNAACCTGCNAACCATTGCCNTGT

GNAACACNGACTCTCCTGTGCGCTACNTGGACATTGCCATCCCGTGCANCATCAAGGGAG CGCACTCAGTGGGTCTGATGTGGTGGATGCTCGCCCNGGAAGTTCTGCGCATGCGTGGCA NCATCTCCCGAAAGCACCCGTGGGGAGGTCATGCCGGACTCTACTTCTACAGAGATCCTG ANGAGATTGAAAATGGAAAAGCAGGCNGCTGNTGANAAGCTGTGANCAANGANGAGTTT TNAAGGGNGANTGGACTGCTCCAGGCTCCAGAATTTACGGGNTGGTTCNCCTTATGGTGG NGAAACTGNNNTTAAAGCCTTGCAGGTGCCTTCCNNGCCCATTTTANCNNNTCCCCATGG AAAACTGGNAGGGCTTAANCCTTCCATTGAAAAACTGGNCTTGCGGCCCCCCCGGCCCNT GCNAAGGNAATNGGNTNGGAACCNCCCCCNN

NACAAANCTGGAGCTCCCCGCGGNGGCGGCCGCTCTAGAACTAGTGGGATCCCCCGGGCT GCAGGCTTCGGGGTCGGCAGCGGCAAGACTGTTTGGCCGCCTCTACAAGGTCCCGGCCNT GTTCAGCTCCAGNGCCAANATNGTCAAGCCCAACGGCNANAAGCCGGACNAGTTCNAGTC GGGGATCTCCCAGGCCNTGCTGGANCTGGAAATGAACTCGGACCTCAAGGCGCAGCTGCG

GGAGCTGAACATCACGGCCGCCANGGANATCNAANTTGGNGGNGGCCGNAAAGCTATTA TTATCTTCGTCCCCGTCCCGCANCTGAAGTNTTTCCAAAAAATCCANGNGCCCCTGGTGCG CGANCTGGAAAAAAATTTCAGCGGGAAGCACGTCNTCTTCATCCCCCAGAGGATAATTCT NNCTACGC(_MSfCTNAAAAAAGCCGTACGAAAAATAAGCAAAANCNTCCCAGGAGCCNTT CTCTGACCGGTGTGCACGACGCCATGCTGGAGGANTTGTTTCTNCCAAANGAGATCGNGG

GCAAGAAGATCCGANTGAAGCTGGACGGCAGCCCACTNATAAAGGTCCNTCTGGACAAA GCTCAACANAACAACGTGGAAGCGCAAGGATGAAACGTTTTTTGGTGTNNANAAACANA CT(^CNGGGCANGGGATGTTTATTTTGAATTCCCCGAGTTTTCAGNTGGNAANCCACACCA ANNGGGGGGGGGGGGGGGCCCGNNCCCCNNNTTTTNNTTTTNTNGNGGGGAANN^

NAAANNNNNNNNNNNNTSINNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNTS^^ NNNNNNNNKNNNNNNNTSINNNNNN^ C

NNNNATCTGGAGCTCCACCNCGGGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGTTAGCAAGAAAGCTGAACGTCCGTGGGAACAAGGGAAGAA NGAATCCGANCAAGGCTTGANGANANGAAGANGGATGGGACAAGAAAATAANGTCCNA NTTTGGNGNCGAACCCCNTTCTNGGCCNNNNCCTNGNTNGNTGNNANGGTNGNGNTNGG

GAAAANGGGGNGCCCCTTTNCCNNCNCATTGCCNACTTGGCTNGCNATGNTNANGNCATN CTNCCNNTTCCNGNTTTTAATNGNATNAACNGNGGNTTTTATNCNNGCNACNANCNNGNC CTNCCNGAATTTANNANCCNTTCTNGTGGGGNCCAAAACNTTCNGGANGNCNTNCCCNTT NGAACNAAAGTTTACCACAACCNGAAGAATGTGCATNAAGGAGAAATATGGGAAGGATG CCANCAACNTGGGAGATGAGAGG(^GCTTTTGCCCCCANCATCTCTGTGAGAANACAANA

AACCCTGTAGCGTNNGTGAAAAAATNCGCATNTNGNAAAAGCTGTNGTANACACGACAC AAGTGCGCCATNTNCATNNGA(^CANNCTGNCCTCTTGNGNTTNTACACNNGTGGCANNT ATTGACACTGTACTNTTTNGTCGCCCCCNTGACCCCACCCANGTNCATNCTTCACCCCGAC GAAGATGNTGCAACCTGTAGAANNNGCCTTNTTCATGGGACCTACNNCACTGGTNGTNTA TTNTTAGGACCCCCTTNTAACCNACGANTGANCTNGGGAAAGACTTTNTNCAGAAANTTC

ATCTTGCNCCNCCCGCCAGGGNNATTCCNANGTNGGNTGGGGGGGGATTGAACCCTCCCC CGGNGGACCCAANCCCCCC(^AN(^GGGTTTCNTTCCANANGGNCNGCNAAAGCANAAN AAAAAATCTTTGNNNNANCTTTNCNTCCTTC TTTNNTNTNANCCNNACGCCCN

TTNAGCNTACTGGAGCTCCACCNCNGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCTAGAGAGGGGTCCATACGGCGTTGTCTTGAATTCCCGT CGTAACTTAANGGGAAGCTTTNACAATGNCCGNANCαSfTTGNTGTCNTNNAAANGAAGGA GNAGNATGTCNTNAANTTCNTTGCANNAGNANCCNNTTAAGGGGNNCCNANCNTNNNNT

NCNAANNGNACNATNCNTTTNCCAAAGGNAAANGGNNGGGNTTTNNCTTANNAATTT^ ANAAGNCCM^GGAAAAACNTCTGGTGGGCCGTTCGCC(^TTGCGCCNTTNNAAACCCGGG TNNATGTCATGGCATATATCTCTCAGGAATANNGGGCACACGAGCTGTGCTGANAATTTG GNGTGNTGCCATGTGAGNNCCACTCTNTATCNGTGGCCGTTTNCNCTCGGAAAα^TTTCTA TACCCANANCCGNCCCCNTTTN(^GAGNNCNAGNNTTTGNGGGGCACNCATANCAGNGGT

GAACACCAANCCCT(^CAGGGNAANCCTTTTTANGNAACCCTCCCCACTTTTGCTGTGGAC ACAGACTCTTCTTTTNTGTCTAGGGGAATTTTCATCCNCCGGNAACAACAAAGGGNGCGC NCCCCTCGGGGGCTTCTGATGTGGAGGNTTCTCCCCCGANAAACTNCTCTTCCTGCGGNCC ACTTCCCAANAAAAACCCCCGGGNGGACGTTCTGCCCCTCTTTT^ C(^GAAGNATNANTTAAGGAAGGAAC^AGCCσ rCCANCTTNNTAAAGGATTTTTKCCA^

CCAAGGAANAANNTNGGGGGGGTGGAAANNGCCTCCCTCCCCCCCACNANAAATNGANN

GGGNTGNCCCCNNNCNGNGGGGGCCTNACTTTTNAAGGAAGGCαWGGNNNTTTCCTTTC

CCAANNCN

TTNAGCNTACTGGAGCTCCACCNCNGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG CTGCAGGAATTCGGCACGAGGCTAGAGAGGGGTCCATACGGCGTTGTCTTGAATTCCCGT CGTAACTTAANGGGAAGCTTTNACAATGNCCGNANCCNTTGNTGTCNTNNAAANGAAGGA GNAGNATGT(^TNAANTT<^TTGCANNAGNANCCNNTTAAGGGGNNCaSTANCNTNNNNT

NCNAANNGNACNATNOSriTTNCCAAAGGNAAAN^

ANAAGNCCNNGGAAAAACNTCTGGTGGGCCGTTCGCCCNTTGCGCCNTTNNAAACCCGGG TNNATGTCATGGCATATATCTCTCAGGAATANNGGGCACACGAGCTGTGCTGANAATTTG GNGTGNTGCCATGTGAGNNCCACTCTNTATCNGTGGCCGTTTNCNCTCGGAAA(^TTTCTA TACCCANANCCGNCCCCNTTTN(^GAGNNCNAGNNTTTGNGGGGCACNCATANCAGNGGT

GAACACCAANCCCTαSICAGGGNAANCCTTTTTANGNAACCCTCCCCACTTTTGCTGTGGAC ACAGACTCTTCTTTTNTGTCTAGGGGAATTTTCATCCNCCGGNAACAACAAAGGGNGCGC NCCCCTCGGGGGCTTCTGATGTGGAGGNTTCTCCCCCGANAAACTNCTCTTCCTGCGGNCC ACTTCCCAANAAAAACCCCCGGGNGGACGTTCTGCCCCTCTTTTTTNTTCNAAAANNNTTT

CCAAGGAANAANNTNGGGGGGGTGGAAANNGCCTCCCTCCCCCCCACNANAAATNGANN GGGNTGNCCCC INNαS[GNGGGGGCCTNACTTTTNAAGGAAGGCCNNGGNNNTTTCCTTTC

CCAANNCN

TNNNNAAAAGCTGGAGCTCCACCGCGGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGCTTGCATTCAGTATAACACAAATGTATTCCCAGTCGA AAGTTCAGTAAGGGCTTGAGAGTAGCAACCAAGAGGTGGAGAGAACAGAGGCTGTTTTTA TGATTNGCCAANATATCCAGTCTCCTNTTTATTNGATTAGNAAAAATATCTTTGNGTNGAA TTCAGGGTCAGTTTTGATCCTGTNCTGCANNAATCTCGANTCAGTAAATNATTTCAGNCAN

NAN(^GAAC(_^CTNTTANNGAAAANCTANTTACCACCCTNTCANCACCANAANTCNCCAG GNCNTANCAAAAANCNCAGCNTATTTNGCCGGNNGAAATCTNGCTGGGCCNTCTTTAAGA ATCσSfGNCACCACAAANCACTTTTNTCTCNGGGNCTCTTTAANAGATTTATTATTAGTATG ACCNCNTCTAGGCAGTTGNGTNCNTNCTTNCNCGCCCACTCAGCACACACACGTCCNTCCT TAAGGAAGCCAANACTTCAGGGAACCTNTNTTCAAAAACAAACTAAGGCTNTNTGATTTA

CAGGATGATGCTGTAAAAGTCACAACGTANCCNTTGGTTGTTGACANCCTGGAGTAGGGG CAAAAAATNCCCCNCCTTTAANGGAGGNCNAAACTTTGGTTTTATNTTGGAAAAATTTNG GGGACAAATTTAGNTTTTTTGGNAAACAA<^TTT^^ GGGGGTCCCGNTTAANAAGGAGCCCCCCAATCTTTTAAACNGGGGTTTTNAAAAACCAGG AGGTTTGGNGGGCCCCAAATTGAAAGGGGGNCCCNCCGGAAGGGGTTCCCCCTTCCNGCC

GGGGGAACCCAAAANCCCCNAAAGGGGTTNAAAAANGGGTTTTTTGGGTTNN

TTGGANACNATNTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAAAAATTGNAAACNATGNTTCATCGACCTTCCAGCCCCATCAAACATTTCA

TCATGATGAAATTTCGGTTCCCTCCTGGGAATCTGCCTAATCCTACAAATCCTCACAGGCC TATTCCTAGCAATACACTACACATCCGACACAACAACAGCATTCTCCTCTGTTACCCATAT CTGCCGAGACGTGAACTACGGCTGAATCATCCGATACATACACGCAAACGGAGCTTCAAT GTTTTTTATCTGCTTATATATGCACGTAGGACGAGGCTTATATTACGGGTCTTACACTTTTC TAGAAACATGAAATATTGGAGTAATCCTTCTGCTCACAGTAATAGCCACAGCATTTATAG

GATACGTCCTACCATGAGGACAAATATCATTCTGAGGAGCAACAGTCATCACCAACCTCT TATCAGCAATCCCATACATCGGCACAAATTTAGTCGAATGAATCTGAGGCGGATTCTCAGT ANACAAAGCAACCCTTACCCGATTCTTCGNTTTCCATTTTATCCTTCCATTAATNATCATAG CAATNGCCATAGTCCACCTACTATTCCTCCACGAAACAGGGTTCCAACAAACCCAACAGG GAATTTNCTTCANACGTANACAAAATCCCCNTTCCCCCCCTACTTTNCCCNTTAAGGGACA

TTNTTANGGGGCCCTTTTTACTAAATTCTAAGCTTTTAAAACCTACTAAGGANCTATTCGC ACCCCGACCTTCTTNGGGANACCCCANATAACTTCCCCCCCAGCCAAATCCAATTTAAAN AAACCCCCCTTNAAATTAAAACCCGGAGNGGAAA(^TTTTTTNTTTGGGATACCCCAA^ TTTACNAAANAATTCCCCCAACNAAACTTNGGGNGGGNGGTCCTTTNCCCCTTAACCTTT TTGAANACAGCTGGAGCTCCACCGCGGGGGCGGCCGCTCTAGAACTAGTGGAtCCCCCGG GCTGCAGGTTTTAAATCAAGTCAA(^ACTTTTCAAAGTAAAGAGTTCACACAACTACGNT CATGAATTTTTTAATCCCGTTGGAAACATATACCAGGAGTGTTCCAGTATACTGGAATACA

GGCACACTACCATTCATGGTATGAATNCTGGGGTTTACACAACCAGTTTCGATGCNATCTG CTCGTNCTATACTGGNGNCNTTNTTNTTO^

NNTTGTNOSfTACCGCTTTTGCCGATATTTTCTCCGCTCTGNNATTTCCNCNNNT^ GNNNCNT(^CTNGCAGTGTCCTTTGANTAACTGCAAGGNTCCNTNTGTNGNCNCNNCGAN AACNNAACAANNTTTCGGGGGGGCGNGCCCCCCCCCCCTCNTNTCTTCCCCNCNCNNGNG

GGGNCCGNATTAAAAAATC CCCCCTCCCGCCTNCTNC^^

GTCGNCTNAG(^CCATGNNGCATTCGNOSINNCGCGTTNCTCCCTNαSfTGCNGANGCTACN NTCCGT<^TNTNTNGTNGGCGNTGNTT^ TNNACCCCCNCCGCNCNTCNCCTCCCGCTCCNCπ^TTCNCCCN CCNGCCTTTNCCCTCNTN NTTNNTTGTCNGTTCGTCATCCTCTTNCCGNTNCTCTNTNTNCNCCTGCCNCTNTNNTNCGA

CGNATGNCNNCTCGTGCCCNNGNNCGNNGCCTC(^TCGCNTCNCCNNCNNCTCCTCNNCC GOsINNGCNNGNG(^CNCCNTCTNCNACATGNTGTCGTCNNNGNTCCTNTTGCGCNCTCNC GNNCGCTNCGGCNGGCGCGCTGTCGCTCGCGCTGCCCACTGCGNACCTCNTNCNCNNNTC CAN(^GCNGNAN(^CTCTTTTTTGTCCGNNTCNGCGCGNNCTCGNTNTTCGTAGCNNNCN AACNGCGTGTCGGCCGTANNTNTTGNCNGCNNCGTCGNCTNNCTNNGGCCC

ANCNCNACTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCT GCAGGAATTCGGCACGAGGGTGAGANTNNNAGATGNGNGANCTTGGNANCAACNTTTNA NGCTCCCGTTCATTCTGNNATCCTNAANANATGGANNTAACTGNCCTACCTTANCANGCN

TGANAGTNTCTGGANNNTGCTACATGTGGTNCCNCACCCCCNANGNNNNTTAGAANTCTT TAGNCATTGACTTCTTACTGTTATAGGGCCNNTACATNTAAGANAG(^TGTTNNCGCCNA NAATATNTATTTGCANTTTTGTCACAACAACAAAAAAGCTCAGCGGTNCCTTCTTCATGGN TTGGAGTGTGTGGTAGCAATGCATCAAGCTCAGCTCATTTCCAAGATTCCACATATCTTGA AGGAGATGTATGACGCAGACCTTTTGGAGGAAGAGGTCATCATTAGCTGGTCGGAAAAGA

CCTCTAAGAAATATGTCTCAAAAGAGCTTGCCAAAGAGATTCGTGTCAAAGCGGAACCTT TTATAAAATGGTTGAAGGAAGCAGAGGAAGAATCTTCCGGTGGTGAAGATGATGATGAA GATGAGAATATTGAGGTGGTGTATTCAAAGACTGCCNCCCCCCCCNAAAGTTGAAAGCTG TAAAGTCTGACAACCAAAGATGATGACNTTTGATATTGGATGNCCNTTNAAAGGGGGGGG GGTGCCACCCCAACCTTAAACAA πsrGNAATNGCTTGAAAAATTNTTTTTTGCATTCATT^

GGCCCAAAAAGTGCCAACCATGGAAATGGGGCCAAAAAGCCTTAAAAATNGGGNTTNAA ACATTNAATGCCTTACACNTTTTTTTAACTTNAAAAAAATGGTATTGGCTTGGG GGCCCTGGTTTTTTTAAAANCCCCAACCAAAGAAAANTTTTTNGGGGGGGTCCCNTCC

NTCCTTNNCATTTNTTTATNNNANNNN^

CCCCC TNGNCCANNGN^JNNTTTTATTGGTTTCTATCTTTNAGCCNNTAGGAN^ CAGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAGGGGTATGATCCGCANNN GTNACTNCCAGGAGGCCGCGGCCAGTGCTAAGGAGGCAGGTGAAGCGGCCAAAGCCAGG CGCTGTGAGCGCGGCCTGAAGACACTGGAGTCCCAGCTGGCTGCTGTGAGGAAAGGCAAA

AAGATCAGTGAGGATGAGATCCCGCCTCCAGTGGCCTTGGGCAGGAGGCCCCTGGTCCCC CAGGAAACAACTAACAAGAGCCCTGAAGCAGAACCCCCANCTGCCCCCTCCGTGGAGCCA GATAACCCCTCαsrAGCCTGANACAAGCCTCTTGGGCATCCCTGGAATTTCTGCCCCACCCG ACNTCANACCCGGACCCACGGGCCCTGCTGCTAGGCCCGGCNNATAGAGTACAAAGTGGC TGCTCTNAATGCCAAGCGTGCTGGAGACCTANACCGTGCCCGAGAGCTTATGAAGGGTTT

GTGAAGAGATTTGCTGCTGTCCTTGGANGCCCTTGGANAANTGGGNCAGCCTTGTGGNCC TNNATNGCTCATGCCCCCC(^TNNTCCANANNNACNNTGGAAGCCCCTTCTCANANGGCT TGNTCCANAGCCCC(_MNNCTAGCNCCCCCTCCCGATGGCACCCCTNTNGNANNTNGNANC GGANATGCNACCCACAATlSπsrAATTGGGCTCTTTTNTACAATCNCCCATTCANNGNCCCNG GTANGGCCCCCTANNGCTTGATTCACNTCCANGAACAANTGCGCTTGTGTAATNCCCCNN

TNNCANNCTANNANTGGCTTGGATCCAANANTNCCACGCCGNATNGGCNANNGTCTCNCC CTANNG(_^TCCWTGTNGGCAAATTTGGGNGNNATATATNACCNNCNATAGAGCCCCCNNN NANNTNCCA(^CNTATNCTαSfTNTTTTGGNNCANNTACNTATNTAANTTCAAANANANNG GCCATTTTTNCTNNTCCC ^CNCATGGN^ TTGACCGCGGNGTCTANCCT(^GGTANACTTTCCTNNNNANATTTATTCATCCNCTATNTA CACNTTGGNTCTNNTGGGNAGACA<^CANN<_^^

NATGTNTGAAATGTGATGNTCTCTNCTCTTATACANGACTNTCTNNACCTNNCAATATACN CTCTGTCNCCC

AAANCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG

GGATTNCGGCACCGAGG πSfCCTGTNTNGNNTT<-^CAGANTTGGACTNGGNσsrCNGGNNN

GGNNNNATGAANANCGNTATTCANACTTNNNCTGCαsπsrTAGTCAANNNACTTTATAGGGA CCπsrAACGTATGCCCTAATANAANATNCTTTAαsrAACCATTTAANCTGCTATTNCTTGATTT

AAAATGGGNNCGCAAAANCCNGTTTGTAACNTGTTCTTGTGCCCAGTGGCTNANATGACC AGACTCCCATNCGCCTCCAGNTTATACCTTACCTNCCNNTANAAGAGAAGACCNNCNGAA CNCNATGATTTTNCTCTTNAGACTNNCGNTCTC ATAAAGANCNNNCNGATATTANCN TTCATTGαsrCACAAAACAANCTTTGNAANANACAAGGCTTCCACNCNCCCCNCCAAATAC TAATGGNGCAGNCCTAACπsrCTGTGNTTTTGATGTTCNCGNCTACCCNTNAANGAGCGGGT

GTNGANCTTCTGTTNGCNGGGATCCACCCGGNCATNNAACTGGCGGGTGATTNATTTNNT TTACTGCCNATCNTTCCAATGCTGGAATCCAAGCTGNNATNCCTNGATTGCNNACAAAAT GGTATNNTTGAACTCCGCTCGTTTGNTTTTC^ NGGNTTGCCCCCTTTGAANNTCTCAANCCCGNNCNTTTNTNGGTTACCCTTNGGGCAAAG GGGAAANNGGTTTCCTTTNCTTCANTTGTTCANGGNTNTTINTANNNNNCNTGGTA

TTNTNTCNAAAAACCCNGNTTNNCNGN^

TATTNTNTGANGGGNTCNCCANTCCCTTNAATTNTNTANGNAAAACNATAANTNTNNANA CNTNCCNNNAACTNTCNGTNTNNNNNNNTNAAANTATTNTANANAANAT^^ NTTC

CAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGGAATTTGAGGATTCCTTCCATCTTCAGGCACTTAAGCTGGTCTCAACNCCTGGTCCC GGGGGGGCAGGGCCCTCCTTTGNNAAGGGTTTCCNAGAANCTGGANGGAAAGGGGGACC AGNCAGGNCAAATGGGGTNGNNGGCCNCCNNNCCCANTNAAANANCANCAACCNGTNAN

CGTGNNNACCAAAGGNNGGNNTTTGGGAANNNTTGNNTCCCANNTGNAAANTAACNGCT TCCTTCCCTTNCCA(^TTNAAANTCANNAAACNTGNAAGAAAANCATNTG(^AATTCTTTC NNGGTGGAACNGACCGGCNTGATATATCCNGACACGAATATGCNCNCTGTGACNTTAAAG TAAGGGCNATATATCTTTGACANGTCCCAAAGCACATGCACACTCTGTNNAAAGTNNTGG AAAAGANNTTTTCTTTCTACTCTTGTGGAGANAATTACTCNNGAANTTANATNGGGNAAG

GGNCCCTNGCCTTNCTCCACTCTNATTTTCTTATNCCCCTNTCCTTCTGAAATGTGTTAACT CATTTCACGCNATGGTGGGGAAATGCNCTCTCCACCNTCATTNCTTTGCCCTCCNCANCAA AATCAGNGCCNCTGATNGTCTTTTTTGGGCTTCCCCCTCCTTANGGGCCTTTTCCTGCNCAN GAAGNCCCCACACCCNAACCTTTTTGCTTTTGTCACTGCTGGGGGTTCAAAATTGATNGGG

GGAAAAAATTCCTANTGAAACCTGNGGGGCGTNTTNTTTGCGGTGGCCAACANNAAAANT NACANNNACNCGCCCCANGGAGCCNTGAAATCTTGGTTCCCTGNAAAAAAAN

TTGAGCCTATATGGAGNTGTATTACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGNNTCCATCTGTACNTGAGCCATGATGACCTGGNAGCGTCTGGGGGCCCCGGG AAAGGGGNAGGGTTNGGCCCCAAACTTGGCTTCCGGGGAAGGACNCGGAAACCCTTATG GGGANAACATTGGNCCATCNTTGGACTGNTTTTGNCTTTCGANCAAGCACCCCCAAATTC GGTGGNGGCAAAANTTTGGGGNCCCAGGACTTCCCCαSfNGCNTTTCCANGGNTGTGAAAA NCATTGCTTGCCCCTNNTGCTGACNGCAAATGAGCANAAGGGCCGGAATTATCCTNGACN

ANGTTNCTNNACNTGACTGNGCCACAACCCTCGGGGCATTTTTCCACCTGNCCCCNTTANG AGGACACCTATNTTGGAGGTGTATCTTGGAGCACGAAAGNGCAGNTTTCCAANCCACATG NNCTTTTTCTAANGNCCACTTGNGACACCCTTTTGNANAGCNAAAAAAGTGAAAANGGCA CCCANTCCC NCCCGTGGTGGTTNTTNCGTNGGGGGGAAGGGGGTNCTATTATTTNAACG NGCCAANGTGGCTTTTGGCCCACCCCNTNTTATTTNACAANGACTGTCCGCAAATNGGGC

CCCCAAGGGGTNGCNTTGTTTCCACAACTTNACGCCCTTOS1NGCCCCCNGNNTNGTTACNC GNNGCCTAACACCCNNAACCCCCCCGAANAANNANCCCCCCCCCGGGANANNGTNCCAA CAATTCTCTTTNTGGG(^GGGTTTTTTACCTNNTTTNTT^ TTACCCCAAGGTTTTNCαs[ANTTNNAGGGAANCCCTAANGGAGNAAANAACNTCNNCCTA ANGGAAGTTTTCACCCCGGAAIWTNGNNTNGGAAACCCCT

CCTTTCCAACCAATAAATTAANCTTTTAAAAAAGNGAGTTTACCCCAAAATANNCTATNTN TGGAANCCCCTTTGGTCCTTTATTTGGANCNCCCNNAAAAACTTTAACCCCTTNNNN^ TTTNAATTTAATGGGCCCCNNNTTNN

TTGAGCCTATATGGAGNTGTATTACAGGGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG GCTGCAGGNNTCCATCTGTACNTGAGCCATGATGACCTGGNAGCGTCTGGGGGCCCCGGG AAAGGGGNAGGGTTNGGCCCCAAACTTGGCTTCCGGGGAAGGACNCGGAAACCCTTATG GGGANAACATTGGNCCATCNTTGGACTGNTTTTGNCTTTCGANCAAGCACCCCCAAATTC

GGTGGNGGCAAAANTTTGGGGNCCCAGGACTTCCCCCNNGCNTTTCCANGGNTGTGAAAA NCATTGCTTGCCCCTNNTGCTGACNGCAAATGAGCANAAGGGCCGGAATTATCCTNGACN ANGTTNCTNNAαSfTGACTGNGCCACAACCCTCGGGGCATTTTTCCACCTGNCCCCNTTANG AGGACACCTATNTTGGAGGTGTATCTTGGAGCACGAAAGNGCAGNTTTCCAANCCACATG NNCTTTTTCTAANGNCCACTTGNGACACCCTTTTGNANAGCNAAAAAAGTGAAAANGGCA

CCCANTCCCNNCCCGTGGTGGTTNTTNCGTNGGGGGGAAGGGGGTNCTATTATTTNAACG NGCCAANGTGGCTTTTGGCCCACCCCNTNTTATTTNACAANGACTGTCCGCAAATNGGGC CCCCAAGGGGTNGCNTTGTTTCCACAACTTNACGCCCTTCNNGCCCCCNGNNTNGTTACNC GNNGCCTAACACCCNNAACCCCCCCGAANAANNANCCCCCCCCCGGGANANNGTNCCAA CAATTCTCTTTNTGGGσsrGGGTTTTTTACCTNNTTTOTTTCGGAA

TTACCCCAAGGTTTTNCCNANTTNNAGGGAANCCCTAANGGAGNAAANAACNTCNNCCTA

CCTTTCCAACCAATAAATTAANCTTTTAAAAAAGNGAGTTTACCCCAAAATANNCTATNTN TGGAANCCCCTTTGGTCCTTTATTTGGANCNCCC^ TTTNAATTTAATGGGCCCα^NNTTNN

ANCNCNATCTGGAGCTCCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCTTNNNNNNAGGNTANCNCAANGGNTNGNCCCATGGCNA GNGClSfNTGTNN WTCNANANTT^^

(^GNt^CTGNNANTTTNANNCCTATCATNATTNGTACTANCACAGNCNTAANGNNGACGC TGACCTTT(^CNGANAANG(^CCTTNAAAGGNATCCNTNC(^CNNNGGGCCATTTTGGCC TTANATNAGGGN(_ΗATTGNCTTTTGATATATTTAGTTAAGNCCCATCNTTNCCNGAATTTT TTTCCCNTTATAACAAATAAAGCNTCCCCCCCANNNGGGACCTNGGCGCCTNTTGNCCCN NAA(^GGCTTTAACCCANTAACCC(_MNTAAANGGCCCAαsrGCT(^ACNCNTTNGNCTTNT

GGTTTTCCGGATTTNATATNNCCGNGNCCCCANNTNTTTTTANATTAANANGGGANCNAN ANCNCATATTTTCANAN(^CCCTTTNNGCGGTNGNαSfNTATNACNNNNNNGNGGGN^ AAAAAAANTTNTAAANNANAAANGGGAANNNTANTTNTTTTTNNNNCCN^ AAAAAAAAANAANAAAANNCTNNGGGNGGGGGGCCCANANNAOSINW^TNTTNNTTTA^ NNANGGNNCNTACATNNCNNNTNNNl^^

NNCCCMNOSπSfNNNlWTNTNTN^ NNNNNTNNNCNNNOSTAANNTNNNTTNOSINTT^^ NNTNTNNCCCNNNNGNNTNGTGNGTCCCN

TTTGAANAACATNTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGAATCCANCT(^AGGNTTNNNGTTNNTGCCCNAGGNTTGCNACNCANNCAT

GTCTAT(^TGNNGCTGACGGNCTGNNNCCTCCACATGCTNATTCNCATGCTGCNTTTTTCG GOSINCTTTGNACANGGCCTGGAGAACTNTNNNCGGNAAGGAGNCNCTGAATNTTTGTTAC

GACCGAACATGGAATNNTGACNNNAANNCNNGN(_^CTGCCTTATCANGAACM^TANCNG NTNGNTGAAAGCAGAACACGNCNTCATGGAGCTTTNCCTCATCCTGTGCTGNCTGCTCTNT TCATGTACATGTGTACAGTGNTTANACCATGCGGCGAGGAGNGCTATNCTATGCCACTGN CTNNTG(_^AACTTTGNTCCANGGTGGCAGGTGTTTACCGGAGCGCTNATNTACNCCATTN ATGOSINAANAGATTCTGGCGGACTTGCCCGTNGNGNNGCATTTTTTNCTTACTGCTTNACC

CTGTCCTGGGTGGCCTTTCCCCTCGCCCTGGACANCGGNATAATCTACCCCTTNTGCNGAA NCAGAAATGANGGCTGCCCTCCCCTGGGTCCCAGCCGACTCCCGGNCCCTTCATCTACCCG NAAGCCCCCACCCTTCCTNCTTTTNTATTTTAAAACAGAAAATAAAACTGTTTAACCCGCC GGAAAAAAAAAAAAAAAAAANTTNGGGGGGGGGGCCCGGNCCCCAATTNCCCCTTAATN GGNGGNTNNNAANAAANNNNNNN^

NNNNNNNNNNNNNNGNNNNNN^

ISINNNNNNNNNNNNNNNNNNNNISINN^

TTGAACACNGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGG

GCTGCAGGTTTTTTTTTTNGANGNNTTCNTTTACTT^

CACCATGGAANGTAAATCCAGGTTAAACNAAAATTCACAAGTCCAACAAAGCNTTCTGNG

ATNNNCCAAAGTTNGNNTAANGNNNGACCAAACCAGTTNGCTCATNAANGACTNCCATN GAAGGGATTTTATTTAGNNGANGATNCTTTGGGAGAAAATAAACNTNCTGCC(^(_^TTAA

AAANGGGTTTTTNATTNNCCTTTG ^TTAGCNCTNAAAATNCANGTTCCAAAANN^

AAATTTATTNTAATNTNNCNNNCNCC^^

NGGGGGANCCCCCAAGTAAANGCCWCTNNTCATNGTTNNNTGACTCTAAANATAAAAACC

CTACTTTCCAAAGGGGGGCTTNTGTNTNCNANGCTTTTTTAGNTTTNGGGTTAAAA^ N(^CNCNAAACTNTGCGAGGGNNGGGTNNAAAANGGGGNGNNNTCCNNC3S[NCNCCNGGT

CTTTNAAAGGGGTTNCCTNTCAAANANC(_MNCCCNACCCCTAAAANANNNCTCNTNCNGG

CCCCANGNGGGCCGGNAAAAAAGNTNNCATTTACGNGGGGGGAAAANNGNNNTCCCNNN

CCTTTCCNTCAANCAGOSINCNGNN^

NNNTNGGCANNNGGNGTCTCTTTTTTTAAAANAC^^ AAGGGGGGGCCNGGGNCCCGCCCTTNCAGGGTNTNTTTANCAAAGGCGCACTGNNTNCTT

NTNNNGGT(^GGCCCAGA(^CTCCCαS[GNNANGNGCCCTNNCTTNGGGNCCATNTCTCCN

CATGCCCNTNGGCCCNNNNNCCGAAACANCCGNCTCTTAAANGGGGGNANCNNTTTTTNA

ANCANCCCCGTNCCCCNGTGCC

ANCAAAACTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGTTTGGCTTTAATATAGGAAGGGCCATGGGAGCCCCTGGCTGAACTGAAGCCTACCC CAAGCCTCCATAACCCGTCTAGGATGAGGCGCTTCCTCTATTCCAGTGATGGATGTGACCG TCCAGCATCACTGACTATGCCCTAGAGAACTGTGCTCCCAGCCTCACCAGGGTCTCATGGT AAAACTCTGGATTTAATTTTGAAGAAATCCTACCCGCCACCAGCCCTACCCTAACACCCAG

TTTCCTTGGAGATATATAGCTGGGTTCTAAGCTTCACCAGGCAAGACGGGATGGAAATCCT GTCACTGAGTACAGGCTGTGTTGTCTCACCCATACCCGCCATGGGCTTCAGCTCCATTTCA AGCTGCCCAGGGCATTCCTTCATCCCTGGGGTGGCCAGCAGAGTAAGAGAAGGGGAGGG GTAGTGGGTGTGATTATCTTAATATGCAGGTGAGAGAGGGGCTAGAGGAAGATGGCCATA GGACAGCTTGGAGTTTTATCCCANGCCAGCTTGCTGTGGGTCTGGTAAGTTGGGTCATGGC

TNCNCTGGGACTGTGGGGAGGAGAGGGACACAGCTTTGAANGCGGTGANGAACAAGTCA TATGTTCCAGCTNCGGGACGTTGTGCTCAAGGAATTTGAAAACCCTTGCTATACCTAAGTC TGGGTACTACANTTTTTΓCCACTNCCCTTTTGNCCCTGGCTTGCCTTAACCCAGGNCCCAA ACCCTTTCTGTTTTTANCCTTTAAAAAGGGACCCCNGGNAAGCTTAAANCCAAGGNTTTCC CTTACCCCTTTGGCNCTAAAGGGCCTNTTGCAAGGNCCCCTTGGGTTGGGGNTAANACCA

ANGGGCCCGGGTTCCAG

NCCTATCTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGAATTCGGCACGAGGCTTCTATCTTGACCTGCATAAAACAGCCCTGGGAGGGATGTT

TAAAAAAATTCAAATTGCTAGCTTTATACCGAGGGATTGTCTCAGTGGATCTGGGTCTGGG TTGTGGCCCTGGAATCACCACTTTTAAAAACAGCATCACAGGTGGTTCAGAGAGCACAGT GGGAGAGGCTGCTCTGAGGGATGGGAAAGTGCAATTCAGTGTTGCCTGGAGGCAAGTGG ACACCTTTTGCCTGAGATTCAGAATGGGTGGTCTCCTGCCAGATACAATCACTGAGAGTTA GGAGTAΛCAAGGATGCATTTAGTCCAGAGGATTACCCAAGCTCTATGAAAATGTTTCTCT

AAATTAGAAAGTCCTCGTGCCTTCTCTGAAAAATGAATGTACAGGTATCCTGTTTACCAAC AGGTGTACTTAGGATTAAAAAACTAGTTTGAAAGTTGTTTTTCTTTGAΛAAAGCAAAAATT TAGCACTGTGACTTGAACCTCTGAATCTTTTCATGCACAGAAAACCGTAAGCCATAAGTAA AAATGAACAAAAAGGACAGAGAGGATCATAATTTTGAAAATTAGTGACAGAGTACCCCTT ACCAGGGGCCTTCAAGGATTAAGGACAGAAAAGATTTTANAAAGAAATGTTTCTTCTTGA

GAAANGGAGTCTCACATGCCAGAACTCAAATTATAAATGTAGTGGTCNTATGACCANGGG GAAGATGCNTCTTGATTTCCCAAAGTGCTCCAGTTTAAAATACNTAAAATGCTGGCCTTGG GACTTAANNCCCTTTAAAGGAAGNGAATTNCTAJSfTTTTGGAGCGGTATANCAAATTTCCTC CCTGGAATTCCTCTTCCCTTTCAAAAAAANTGATTΓGNTAAAAAAGCNCNTΓTOTΓC TANAACTITΓTTGNATGGCNTTNAAAAATΓAAAAAGNCTTTTNN

ANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA

GGCTCTTTTTTCTAGTCTTCTTCCCTGTAGGCAGTTTTAGGTGGAGTCAGGGGACAGGCAG CTΓΓCTGCTGAGGGACATGACACGTCCGTTTCCAANACAGAAAGTGGTTGGCAGAAGGTG TAAACCCTGAAGTCCCAGTCCCCGAAATCTCATTACCCTCAAGGTCTTCACAGTGATCCAG TGTCCTGAACCATΓGCCTGAGCAATAGAATAACTGTGCTTTTGAAGTAATGTCTGACTCTG AAGGCAGCACCTGACCGCTCCCCCGCGTGCTGGGCTGGTCGTGCCGATACTCTGGGCTCCC

AGTTGCTGCTTCTCAGATATACCTCTTGCCCGACTGCCGCCTCCTCAGTCCACCTCATCCAC TCAACCATGCCCCACAGACATCTTAGGTAGAGGCAGGAGAAGCCAAGGCGTATGCACAGC TGCCCAGTGACTGCGCAAAAGAACTCACACTGGTGGCTGAGGCTGGAAGGACACCAAGA GTCNNCTΓTTCACCACAGGTCACCAGTGTGATGACAATATTCCAGGCTTGACGTGGGAAG AGACAGCCNANCTCAGACTTAACTAAATGCGTGGGGCTGTATTTTAACAACTGGGCAGTT

CTC^GAAGGTGGNTCA<^ACTTTAGAAAAAGGAAAGCGACCCTGATGTTNCCTAATTAAC CACCATNCANTAGGGGGANGCCAAATACANCCTTTGAATTGGCTTAAACTGGAGGAAGGC ANCCCCAGGANΓΓTΓTNTTCTTNGC^^ ATTTGAANTTTTTAAACTTCAAAAAGGCCMANGGCCTTTTNGGCTTT^^ AAAAAAAGGGNATΓTΓTTCCCCCTTTATNGCAANGCGGAAAGGGGCNANTAACCCNGAAN

NGGAAAAAANAAACCTTΑWACCANGCCCCGGGAATTTTCCAC(^TTTCT

ANNNCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGCTCTTTITΓCTAGTCTTCTTCCCTGTAGGCAGTTTTAGGTGGAGTCAGGGGACAGGCAG

CTTTCTGCTGAGGGACATGACACGTCCGTTTCCAANACAGAAAGTGGTTGGCAGAAGGTG TAAACCCTGAAGTCCCAGTCCCCGAAATCTCATTACCCTCAAGGTCTTCACAGTGATCCAG TGTCCTGAACCATΓGCCTGAGCAATAGAATAACTGTGCTTTTGAAGTAATGTCTGACTCTG AAGGCAGCACCTGACCGCTCCCCCGCGTGCTGGGCTGGTCGTGCCGATACTCTGGGCTCCC AGTTGCTGCTTCTCAGATATACCTCTTGCCCGACTGCCGCCTCCTCAGTCCACCTCATCCAC

TCAACCATGCCCCACAGACATCTTAGGTAGAGGCAGGAGAAGCCAAGGCGTATGCACAGC TGCCCAGTGACTGCGCAAAAGAACTCACACTGGTGGCTGAGGCTGGAAGGACACCAAGA

GTOSΠSΪCTTΓTCACCACAGGTCACCAGTGTGATGACAATATTCCAGGCTTGACGTGGGAAG

AGACAGCCNANCTCAGACTTAACTAAATGCGTGGGGCTGTATTTTAACAACTGGGCAGTT CTC^GAAGGTGGNTCA<^ACTTTAGAAAAAGGAAAGCGACCCTGATGTTNCCTAATTAAC

CACCATNCANTAGGGGGANGCCAAATACANCCTTTGAATTGGCTTAAACTGGAGGAAGGC

ANCCCCAGGANTΓ TTNTTCTTNGCCC^^

ATTTGAANTΓTTΓAAACTTCAAAAAGGCC^ANGG

AAAAAAAGGGNATTTΓTΓCCCCCTTTATNGCAANGCGGAAAGGGGCNANTAACCCNGAAN NGGAAAAAANAAACCTTCNNACCANGCCCCGGGAATTTTCCACCNTTTCT

TTTGAGNCCNATANGGGAGNTGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGATCCC CCGGGCTGCAGGAANTTCNGCNCGAGGCTNTTNNNGGTGTNCCCANACCNGCCNTTTNCC TTAAACCTCNGGAGGNCCCGCANNGTTAANAGGGGAAATCATTACCNCCATGAGACAGG

GGTNGNNCCCNAGANTCGTNNTGGGGCCAGNTCCACTTGGACACCTTTGTATGNGGNANA CACTTTTΓΓΉCANTGNAGGTANACTNTAAACGGACTTATACTTGNCTCTTNANANAAACTA NGGACTΓΓCCCAAATTNAATACNCNACTNNGNACTCCNACAAACTCTATTGANCAGNCAA TGNATGANNCTNAACGANTTCATAANAGATGANAGAACCANNGCACCCCTTNNGNNGAA TCNTTNNTGGTNTNCACAGAAANCTNNC^

AGTGTGCGCTCGGGANTTGTAGTOWCCCANATACNNNNATNNGTGCTTTCAGGAAAANC CTNTGNCCNCT ΠSΓATCTTNTCCTNCTANATAAANCAACNTCTNGCCCCTCCTTCCTNANAA ANATTAATC WATTCACCTGCCCTTAAAANTC^^

CTTGGTTTTTGTNGAANGANANANANNNCTTNANTTCTGGCTNCCACCCGCCCCCNATTGN NTT^JN π [AAGNAAANTCCAC TTCANTTTATANACCTTCTTGAANCTTGATAC ^^

AATNCTNTTTGTGGCGTTGGGGGCAAT<^ATmTCCCTNTTTCCCNT^^ AACTI NΗ^JNNNANTCCTCGCGANNCCNCTANANTTTNTTTAGTGN^ GNNGGCNCCAATTGTCNCNNTGNAGTNTTCTTNACCTCTGGTCCAANATTCNANTTGTANC GATNTTTGTANCCAACCNATTTTTNTCTC^ NNTGGATGNCGTCNNNNGTTTTNCACTCT^ CTAGCGGAANTC^TCCTNTTTNCTTCTNNC^ NCN<^TTCTANTATTCTTTAATGGCG^ TNTTGNCAGNTNCGNNGGACT(_ rCCCTCCTO^ TTTTGt^AGNNNTGCGTTNTTATNNCATCTCCTCTGTNGNNACAOSINCCC ^'

TTTGAGNCCNATANGGGAGNTGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGATCCC CCGGGCTGCAGGAANTTCNGCNCGAGGCTNTTNNNGGTGTNCCCANACCNGC(^TTTNCC TTAAACCTCNGGAGGNCCCGCANNGTTAANAGGGGAAATCATTACCNCCATGAGACAGG

GGTNGNNCCCNAGANTCGTNNTGGGGCCAGNTCCACTTGGACACCTTTGTATGNGGNANA CACTTTTTTNCANTGNAGGTANACTNTAAACGGACTTATAC1 GNCTCTTNANANAAACTA NGGACTTTCCCAAATTNAATACNCNACTNNGNACTCCNACAAACTCTATTGANCAGNCAA TGNATGANNCTNAACGANTTCATAANAGATGANAGAACCANNGCACCCCTTNNGNNGAA TCNTTN TGGTNTNCACAGAAANCTNNCTNATTNNNACTNTCATCTATNGNNAACCTNCN

AGTGTGCGCTCGGGANTTGTAGTCHNCCCANATACNNNNATNNGTGCTTTCAGGAAAANC CTNTGNCCNCTNNATCTTNTCCTNCTANATAAANCAACNTCTNGCCCCTCCTTCCTNANAA ANATTAATCTTNATTCACCTGCCCTTAAAANTCTTTNGNCNGATNCCNAGATGCNNTTTGA CTTGGTTTTTGTNGAANGANANANANNNCTTNANTTCTGGCTNCCACCCGCCCCCNATTGN NTTNNNNAAGNAAANTCCA(^TTCANTTTATANACCTTCTTGAANCTTGATACCNTCGATC

AATNCTNTTTGTGGCGTTGGGGGCAATCNATTNTCCCTNTTTCCCNTTNNTCTTACAATTT^ AACTTTNTNNNNANTCCTCGCGANNCCNCTANANTTTNTTTAGTGNTsπSINA GNNGG(^CCAATTGTCNCNNTGNAGTNTTCTTNACCTCTGGTCCAANATTCNANTTGTANC GATNTTTGTANCCAACCNATTTTTNTCTCC^^ NNTGGATGNCGTCNNNNGTTTTNCACTCT^

CTAGCGGAANTCNTCCTNTTTNCTTCTNNCAATNNNTATTATAACGTTCTTANTNAACNAT NCNCNTTCTANTATTCTTTAATGGCGNNTATNAANTTGNNTNTTGGTTCNCCNNGTCNTTC TNTTGNCAGNTNCGNNGGACTC^INCCCTCCTNTTCCNNATATNTTTAATCTTAΛTNTTNNN TTTTGCNAGNNNTGCGTTNTTATNNCATCTCCTCTGTNGNNACACNNCCC

TTTGAGNCCNATANGGGAGNTGTATTACAGTGGCGGCCCGCTCTAGAACTAGTGGATCCC CCGGGCTGCAGGAANTTCNGCNCGAGGCTNTTNNNGGTGTNCCCANACCNGCCNTTTNCC TTAAACCTCNGGAGGNCCCGCANNGTTAANAGGGGAAATCATTACCNCCATGAGACAGG GGTNGNNCC(^AGANTCGTNNTGGGGCCAGNTCCACTTGGACACCTTTGTATGNGGNANA

CACTTTTTTNCANTGNAGGTANACTNTAAACGGACTTATACTTGNCTCTTNANANAAACTA NGGACTTTCCCAAATTNAATACNCNACTNNGNACTCCNACAAACTCTATTGANCAGNCAA TGNATGANNCTNAACGANTTCATAANAGATGANAGAACCANNGCACCCCTTNNGNNGAA TσS[TTNNTGGTNTNCACAGAAANCTNNCTNATTNNNACTNTCATCTATNGNNAACCT^ AGTGTGCGCTCGGGANTTGTAGTCNNCCCANATACNNNNATNNGTGCTTTCAGGAAAANC

CTNTGNCCNCTNNATCTTNTCCTNCTANATAAANCAACNTCTNGCCCCTCCTTCCTNANAA ANATTAATCTTNATTCACCTGCCCTTAAAANTCTTTNGNCNGATNCCNAGATGCNNTTTGA CTTGGTTTTTGTNGAANGANANANANNNCTTNANTTCTGGCTNCCACCCGCCCCCNATTGN NTTNNNNAAGNAAANTCCAσSfTTCANTTTATANACCTTCTTGAANCTTGATACCNTCGATC AATNCTNTTTGTGGCGTTGGGGGCAATCNATTNTC^^

AACTTTNTNNNNANTCCTCGCGANNCCNCTANANTTTNTTTAGTGNNNNACT^ GNNGG⁽^CCAATTGTCNCNNTGNAGTNTTCTTNACCTCTGGTCCAANATTCNANTTGTANC GATNTTTGTANCCAACCNATTTTTNTCTC^ NNTGGATGNCGTCNNNNGTTTTNCACTCTTC^ CTAGCGGAANT(^TCCTNTTTNCTTCTNNCAATNNNTATTATAACGTTCTTANTNAAC^

N⁽^CNITCTANTATTCTTTA^ TNTTGNCAGNTNCGNNGGACTOSfNCCCTCCTO^ TTTTGCNAGNNNTGCGTTNTTATNNCATCTCCTCTGTNGNNACACNNCCC ,^J

ANACAGTTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGC AGGAATTCGGCACGAGGATGGTGAAGTCCANGGNCATACTGAGAGTATTGCCATATAAAT ATTTCACCATAGATTGAGGATTGACCTAAGGGTTCTCTGTGGAGCACTCTTTTTCAGTGAC TCAACTCTGAACTTCAAATTCTGAGATCTGATGAAACATATAGTTCTCCAACTTGAAATCT GTTTTCTGTCTACATGGAAAACAAGCTATATCTACACAAATGGAAGCTTATTAATTAAGTG CACTGGTGTCGTAAACTGGCTCCATTTCAGACAAGTTGACTCCTTTCCAAAAGAAAGAAG CTAAACAGAAAACTACCCCTTATGCAGAGATGACCAGCCTCTATCAGCCCTCGGACATTT GTATGTGTCTGGAGGTTCCTGGGGATCACTAGTTTTTTAATTCAGAAGAAGCAGAACACAT CAGCAGGGTTCCTCTTACCTTACTAATGAATAAACTGAGGCCCAAAGCACCTGATTACAA

CTTI GGTAACTTTCAAATATGCTGGTAAGTGGAATTTTGAAAAAGAAAAACAAAATCAA CATGACTGCAGTGGCGAGATCCGCAAACTCCATGGGGGTTCAGAATTATTGNACAGATGC CCCAAACTTATCCTTGGGTCTTAAGTTAGGCAAACTCATGAACAAGATATATGCATCTACA TACATTTATCTAACTTGNCAGGCTATAAGANAGACTGGCAACTTAAATGNATACATCCTTC TATTGGCANCCTTTGGGGTCAGCNTTTCTT<^^

TTTTNAAAAAATNTCNTTT ACCTTC^ TTTCAA

TNNNNCCCNNCTGGAGCTCCACCCGCGGNGGCGGCCGCTCTAGAACTAGNGGATCCCCCG

GGCTGNAGGNTTTTTTTTTNGNNGGGN^

ATCCCCANGGAANGTAAATTCAGGTTAGACGAGANTTCACANGTCCANCAAAGCNTTCTG NGATATNCCAAAGTTNGTNTAANGTCTGACCAANCCAGCTNGCTCATCAANGACTTCCAT NGNAGGGATTTTATTTAGTNGANGATNCTTTGGGANAAAATAANCATNCNGCCCACATTT AAAANGGGTTTTTCATTTNCCTTTGCNTTANCACTTAAAATNCATGTTTCAAAATAATT^

AAATTATTCTAATNTANCAGCAGCAAAATATAATTCTGCANTTNCTAAANAGCTAAAAGG GANCCNCAAGTTAAGTTNCTCTCATGTTTATGATTCTAAAATAAATNCTACTTCAAAGNGG CTCTGTTACCAGCTTTTTAGTTTTGGTTTAAAAACNCNC^CAGACTTGCAGGGAGGTTTAT AANGGGGGATTCCATGCNCTGGTCTGGAAAGGGTTCCTCAAGAGCCCANCCNGCCCTTAA AACAGTNCTCAGTCCNCAAGGCCGNCANAAAGGTACCATTAACCTGGGGNAAAATAGGA

TTCCTACCTTTCCTTCAAAAGCCTTTGGATNTTCTGGCAGCAACTGGGGNN(^TTTTCCAG GATGGCCTTGGTGNCCTTNTTTTAAAANTAAATTTTCACNANAAANAATTTAANAAAGGG GGGNCCGGNCCCCCCTTTTCAAGNGNGNTTTTNAAAAGGGGCCCTGGTTTNTTTTTGGGGG CNGGGCCCGGNCCCCCCCGGGAANGGGCCCCCACCTTGGGGGACCCATTNCCCCCCNTNA ACCTTGGGGCCCCαsrCGGCCAAAAANAAACCCCTCCNAAAAAAGGGGGGNCCCCATTTTT

CAAAAAATCCCCCAGGTTNTTTGGGG

ANCAACAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGTTTCTACCCATTGCCTGCGGTCATTTCTTTATCTGAGCTCTTTGGTTTGATGTCAC

CTTTGACCCAGAAACAGAGATATCCCCTGATATTTTTTTCTTCATATTTCTCITTCTTTCCT^ AGCCCGTAGGTTTTGTCAGTTTTGACAGTCGCTCAGAAGCAGAAGCTGCCAAGAATGCTTT GAATGTAAGTACGAATGATGTTCATCTTCGAGGGTTTCCGTATGAGGTGAAGGGAAAGTA ATCGAGTCTCTTTGGACAGGAAAGCAAATGGAAGGGATGTGACTACTTGATCTAAGAGGA ACGGACTCTAATTAGCCGCATAAAGAGATTTTGCCTAAAATTGTGGTTAGATGTGCAGACT

ATTAAATAACACTTTGCTCGTCTCTAGCCCTTACTGTAATGCTCAAGATAACCTGATGCTG GGGATTTTATTTTAATTCAGCCCAATCACATCCCATGGTGGGTATGCAGTTTACTTCAGCC CCCATTATATTCTCAGTGGCTAACCCCAAGTCAAGAATAGATCAAAATCTTGGCTTTCCTT AACACGTGANGGTTTTAACTTATGTGGCTTTTAAGGGCTTCCCTGGCTGNCCCNTTGGTGA AGACTCTGGGTTNCCAATGCACANGCACGAGCTCCATNCCTAGTCAGGGCTGNCTAAAAA

TATATTTTTNAAAAGNATGTGACTTTTAAAAAAAAGGTGGAGGCCTTTATTCTGGATTGGA TTTAAAAATTGCATATCTGGNTTCCCCAGTAAACATTCCGCANTTGGGGGGGCATAAANA AAGGATTTCCTTTTTCCAAGGCCCGAAAGGGGAAAAAGNGGAAAGGG

NGNNTNNCNATNCCTATTATTAAAANNNNAGT^

NNNCC^TTNNTNCCCNNCCNTNGGGNGGNTNTTNNTTGGNGACTATCTTGAAGNCCTATN

GGNNCGCACACNGTGGCGGCCGCTCTANAACTAGTGGTCCCCCCGGGCTGCNGGCNATTC

NGCCACGAGGCAATGNCrrCAGNCNCNαsπsrCNNTCCTTTNTTGTATNTNGGNCAATNATT NTGACNATGGNTCACATNATNCGANATNCATNACTNTTGTCCCNTNTAGNNTTTTTTNCNN

TTCCCTANNTTNNTNNGTNANTCAATNNGNTNTTCCTNCNNNGATOSINNTNNGTCC^

TTNNNTNNTSΠSΠNTCANNNTNTO^

TACTCCCTAGANGNTTTNNNOSINNGTNGGN^

TTNCNATANTATNA(^GNNNAGAATCNCNATNAACCTNNTNNACTNNTTNT^ GACNANTGCTNNTTCTTTTNNCTNNNTTCNNNTNNGTOSIN^ TTGTTNGNNCTTACAGNNTTNTNTGNN^ CTTTGTTGGNGTTCNNTTNTNGTNTCGNANTO^ ANNNAGCTTCANNNCNTTANTNNACTNCTGANNNNATAATNCGAAGATΑSΠSITNANCAATT NTTTTNTNCTNTTTCNGACGNNTAT^

GACCCOSRATTTNTTCNANTNTANGNNCTGTNNNGNAGGANTCAJSRTANCTNNGNNNNTGC^ TNTAATTANNTTTCTCANNTGNANAATATGCTO^ NAN⁽^GTTGNCAAACNNTTTCTTTTATNNNCTNTCNTTCGTNNAANN^ NATGTNTANCTNNTTTGTGNNG<-MWTANTANTTACTATATCTGGGAAANNATANTNTGN CTAGTNTNTAGNTANAGCANTTTCNNTNCGTATTAT(^TTTCCNNCTCCANNNNTNNTNAT

NTNATGNGAATN⁽^TNNTATNCGTN(^TΑSRTNTNTTACTTNATNGTCTATAANANT^ TATNCTTCTNTNACTTATATATTNATCTCNNNACTGTGTNANTCTGAGNTGANATCGATAA TACTACNACTTTATATNNTTTAGNTNTANTGNGNCGCAGTGTNTGAGNNANATNTGTGTGT GAATGTTATCTGTATNTTGTTANACAATANCNGTATATTAACTTATNTCGNACGTNTACNG TCGCTNTCGNGNACGTNATGAGNNTCGTGANNTNATTNNCGANATNTTAGATNTGNGANT

TNAGANACNTGTTTCG⁽^TCGCGCGCTNNGATTGANTATNTNTTNTNCC

AANNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCGGGCTGCA AGGGCGNCCGTTCTGGCCGCACTGCGCTCGCCCTGAGCTCCGGGCTCCTGCTAAGCCAGC

GCCGNTGTCGCCTCCNTCCAGTCGCCATCATGATCATCTACCGGGACCTCATTAGCCATGA CGAGATGTTCTCCGACATCTACAAGATCCGGGAGGTCGCGGACGGGCTGTGTCTGGAGGT GGAGGGGAAGATGGTCAGTAGGACAGAGGGTAACATCGATGACTCGCTCATTGGGTGGA AATGCCTCCGCTGAANGCCCCGAGGGCGAAGGNNCCGAAAGCACAGTAATCANTGGTGT CGATATTGTCATGAACCATTACTTGNANGAAACCNNCTTCACAAAAGANNCCTACAAGAA

GTACATCAAAGATTACATGAAGTCAATCAGAGGGAATCTTGAANAACAGANACCAGAAA GAGTNCTNCTTTTATGACNGGGGCTGCANAACAAATCAAGCACATTCTTGCTAATTAAAA AAACTATCAGTTCTTTATTGGNGAAAACATTGAATNCAGATGGNATGGTTGCTCTGCTGGA CTACCGNGAGGGATGGCCCNACCCCATATATGATTTTCTNTANGGATGGGTTAANAGANG GAAAAATGTAACNAGGNTGGCTNTTCTTTGGATCNATCCCTGTCANCATAACTGGGTTGG

GTNCTGGTTTTCTTCCCNCCNCACCNTNGAATTAAACAGATGGGACTGGANGNCATCTNN

AAACNGGGGTTNNGGGGGTGGNTAAAAAATAAAACCCCTTTTAAACT(^AAAAAAAAAA AAAAAAAAAAANTTNGGGGGGGGGGCCCCOSfNCCCCATTTNlStNCTTTNN^ NNNNTNNAANNNNNNNNNNNNNNC

ACTNGCAGAAGTGNGNNCCGANGNACGACGTGACACNNNCNACNCTTGCNANCNCCCAT

CTGGAGCTGNCACTNACANTGGCAGGCCGCTCCTANNACTAGATGGCTTCCCCCCNGGTC TGGCANGTAAGTNGNTNANNCNGGTNNTTNNGGTAGAANTCNTNCCATCNGGAGNACCA

CNNCCCGNGNGNGNNAAGTCTNNGCNCCNNTTNTGNTTNCNNOSINGNAGNNTNGTTGAG

GNGCGTGNNNGCGCCANTANNANNGNNTSINNGNNCGGNGGCCHNNNNAGNNGNTNTGNG NGTTNATNNNGNNAGANCGGGNGGNNAGGNAANNTCAN1SINNANNGNCCNTGTNNNGAG CC^GNGGNATTNTNTCNNCTAGNGCNAGNTN^ ATNCCCCGNCNCGCGNNCNNNNNNTCTNNNCCCANNGANCTGGNNNNCGNNCACCNNAA

TTCNTSπS[GNTNTNGTCGGNNNGNT<^GTGNATNNTGTAGTNTNANTNTS[NCGGT^ NANGNCTNNGNNATGNGTGGNTNNNGNTNNGANNGTCCGNNTANCGNNTGGNNCNGNGN GNNGGGCC<^TNANNNNGN(^ANlSπSINN^ ANANISnSINNNGCNAANCGANANNNTNOT^ NCGNGCCTTGNGGNNOSπsπsrcαSINTNNTTATα^NNNNCNCTAANNATC^^

TANNGNTNGNNGNNGTGCNTGCCNNTNTTCTNαsπsrTGTO QSrGTNGTACNCAGGCTGNGNG CNAGNNNNCNNl NGCNNCTNNANGATCTGTAGNCANσsrCANGCNATTNCGNNNANTCAT A(-^TNCATCTTNACTACCTCGTTNAGNNCNCTNCAAGTCTACATNTGNNTGGNACAATCC NCTGTNCTANGGNCGAGGCGCTTNACTTACNNAAGTTTNNAGTAGNNTCNANTCANGAGG ACGANTGCNTTAOWACTCNNCGCNCNGCCGNANCTNCANNCNGCANCNAGTNNTGTNNT

ATTANNNGTNTTNG(^AGANTNNGANANCACNGNANTNGNGTTGTNCGCGCNCTCNNAC NNCNCTGCCNCANCCGANNACGNCGNNNGNCN^ ANANAGNTCNCTNCNGANNNANNGAATANNTCAGCAGTGCACCANTNGCATGNCGCGCA NATANACNCGACTNCGNTCNGTGCGACNANTGTNTNATNANAGNNCGATCGCGTNCGCGC CCGCNGANACT(^CTNTGNNNTTNTGNTATCNCGANCANATNCANGCNCNCGCGCCC

TTNAGCCNATNNGGAGCNGCANNNCNGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCN

GGCTGGANGNANTNNGGCACGAGGCAGAAGTTGTGGGAGTTANCAGAAAAAAAGGTGNC CAGCCCACAAAACATAAAGNGNTCACTATGTGAGCCTTCANANAGNGNTCACTGATCCNT GCTCTAAATGGGCCTCATTCTGGGGCTCGAGCTGACCAAGCGGATATCACCTANGGNGGG GCTGNTCATTTANGGAAATGAAAAAGTAGGACAAGNCACTTACAGGCCCTTTAAGCACTC TCACTGGCCAGGGCAGANCCCATGGCCACCCCAAGCCCAGGGAGTGTGATCCTTCCGCGT GCCTTGGAAGAGAAGCAGAGATATTTGGAAGACGATACTACCAACTAACACATAGCTGTA TTTCTCTCTCTCTACAAAATTTCTTTTGAAAGTATTTTTTCTTT^ CCTTCAGTNAAATGCAAAGACTTAGTGCACACCTTGTAGATNTTTATGTGCACCCTANAAC CCATCAACCANATCAAGACACTGAACGCTTTCACACCCTGGTCACTGCCNCGCCTATGCAC ACCCGCAGCCTGCCACAAATAACCACTGGTCTTGACCGTTATCACCAGAAGATATGGTTG

GTTTAAAAGCTTCATGTAAAAAAATTCTGGGGACTCTTGCTCAACATTGNATCTGGNGAA GTNATCCATGGTGGGGATCAATTTATTAAATANCTCNCTTGTAGGGGTCCTGGCATGGNG ACTTAAAAACCACNGGTTTTTGGAATCCCTTCCTACTGGTGGGNGGGAAANTTTTGGGTTT GNNNTCCAANCTTGNTAGTTGGTTNTNNAAATAAAAGGTNCCTTCCNNACCCMSINNNNNN NNNNNNNNNNNΠSΠSINNNAAANNN(^TNGGGGGGGGGGGGGNGGGNCCNCCAAAAN^

CCCCATATTNGGGGGG

TTNAGCCNATNNGGAGCNGCANNNCNGTGGCGGCCGCTCTAGAACTAGTGGGATCCCCCN GGCTGGANGNANTNNGGCACGAGGCAGAAGTTGTGGGAGTTANCAGAAAAAAAGGTGNC

CAGCCCACAAAACATAAAGNGNTCACTATGTGAGCCTTCANANAGNGNTCACTGATCCNT GCTCTAAATGGGCCTCATTCTGGGGCTCGAGCTGACCAAGCGGATATCACCTANGGNGGG GCTGNTCATTTANGGAAATGAAAAAGTAGGACAAGNCACTTACAGGCCCTTTAAGCACTC TCACTGGCCAGGGCAGANCCCATGGCCACCCCAAGCCCAGGGAGTGTGATCCTTCCGCGT GCCTTGGAAGAGAAGCAGAGATATTTGGAAGACGATACTACCAACTAACACATAGCTGTA

TTTCTCTCTCTCTACAAAATTTCTT^

CCTTCAGTNAAATGCAAAGACTTAGTGCACACCTTGTAGATNTTTATGTGCACCCTANAAC CCATCAACCANATCAAGACACTGAACGCTTTCACACCCTGGTCACTGCCNCGCCTATGCAC ACCCGCAGCCTGCCACAAATAACCACTGGTCTTGACCGTTATCACCAGAAGATATGGTTG GTTTAAAAGCTTCATGTAAAAAAATTCTGGGGACTCTTGCTCAACATTGNATCTGGNGAA

GTNATCCATGGTGGGGATCAATTTATTAAATANCTCNCTTGTAGGGGTCCTGGCATGGNG ACTTAAAAACCACNGGTTTTTGGAATCCCTTCCTACTGGTGGGNGGGAAANTTTTGGGTTT GNNNTCCAANCTTGNTAGΠGGTTNTJNINAA^ NNNNNNNNNΓ>ΠSΠSINNNNAAANNNCNTNGGGGGGGGGGGGGNGGGNCCNCCAAAAN^ CCCCATATTNGGGGGG

TTNANCNCTATCTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG

GGCTGCAGGAATTCGGCNCGAGGNCGTTNTCGTATNGCCTNMWNNGATNNNTGCAGGG NANTNNNNNNTNACCTNAAGGANAANNCCTGNCTCCGANAGAANCTGCAAGGCGGNCCN

TCCGNGGTTNGTCCNCTGTTNATTTNACTANGAAAACCCCANAACNNGAAANTGCTTNGC

CNGCCGGGCCNNTNCNNTTTTITNGNGC^

CNNAAGNTNTGTTCANCNGNTTTAATTCCTNNGTCAAGNCANTNCGNTTGANNAAAAANC

AG(^TTAAAAATATCNGNGATAANAACAATTTGAGGGCNATTCCTNTTTNTGNCCAGNNG GGANTGTANTTTNGGNGTNCANNCTTTGTCTNGGGNTAGGGCCGAAACCTTNTGTNTTNN

NCCCCTGGGNTTTCCNANCCTGAAAAAANGAATTNCCGGGGGGNNCCTCNCCCNCNAAAG

CCCNNNTNNTTTTGTNTGTTTNANNGGAAGACCTTTTTCAN^

GGCCAANCCTCTTCTCNTlSπNrGGGGCCCAN^

AANAANCGCNGGNAANNTGTGCTTTTTTTNTNTGCCC^ CTGGGGNTTAAAANNACCCTNGGCNCCNTNTNTTTTTTTTNANAANNATNAGNGGA^

GGGGGNNNAAAAAAACACCCACACCCANTTTTTTTGNATGGGGGGTTTTT^ TNTCTCCAAAAAANAAAANATTTTNGGNGCGGCTNTTTTTTAGAAAACNNCAACCATCT^ TTTTTTTGAAGAAGGGGGGNNAANAANNAGGCCCTNO^ GGNCCCCCCCC(^CNCCCACTATTTTTNTTGGGTT TTNNNNCNNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGCTGACGAGTATCTTTCACATGATTAACCAAAAAATGCATT ACTGCCTTTGGCACACTGCAAAGCAATCAAATAATCCATTTATTTGAGAATAAAAACCTA

AATTTTAAAAAATACATATATTTTCAAAACGATTAAGAAATTATCCAGCAGTATTCTAGTC TGATTTATATACATAATACTAACCTGTCTTGAATATTCTTTCTGACAATAAGAAAATATGA TTTGATGAGTCGTTCAATAACTTCACAGTCTCGCTGTTCACGGGCAGATAGTTTTCGTGCA ACAGGAACTGGCTAAATTGGGTGAGGGGAGAACAAATTTACCGTTGTGCCATTTTGAAAT GACAACACGTAACAGTACGTTTTTGAGATACCAGTTCCTTCTGTCTTTTAAAATGCTTTCTT

GGTAACTTGGTTCTTTGTCCTCAATCATTCTACAGCTTACCAAATTCTACAGCTTACCACAT CCAGCAAATTCACAGCGTGGCCTTTTTGTGGACTGGCTGGCATAATTGGAATTGGTTTTGA TTTTΓCCTCAGCTAGTAACTCCTCAGCTTTTGGAAGTTTTCAGCATTCCTCTCCAGTTGNCT GGTGGTGGNTCTTGGAACAGCATNTNCAACCCCACCACCTTCAGATGCAGCCTGAAATAA CATGTTCCAAACCTGTACCAACCATATCAACTGGCATTATCTAAACAAGGTTANTTTTTTG

GTANGCGTCAAGGAAAAACCCTCTAATNCCATNTGGAGNTTAATCTATTAAAAAAAGCCN GGTCAAAAANAAATGGGGACTGGGCTTGTCCACTGGAACCCTGGACTTGCTTAAAAAAAA

TTNNANCNCTATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCC

GGGCTGCAGGAATTCGGCACGAGGNCCGTGTTNTGCNTCNAANNCTGCTACGCTANCNCG GTNAANGCTCAGNAANTGGANNTGNTATGGTGAACGCTACTGACNTCTTTTCTGTCTCCCG TTGGCGC^TNTTGATAACTNATTCTGACCCAGTGACTGGGCCAGNTCAATGCGAACCATTT NNTTTATTATGCGNNANTGGATGNGNNNCGGGGNTCAAAGCCTTTATGAGAANNTCTACC GTTCTNGGCTNNANGCNAAGGGAGGAGTAAATTTTNNTTTTGCAGCTGGACCNGNNNNT^

TTGGNCAANCCACGCTCCATCTGGTTTGAAGACTATTNAAATTGGCNNTTCTTGAAGNTNN GCTCGAAGNAANGGGGATGGNGATACCCAACTTCNGAANGCGGCTTTGGNNTTGGNAAN ANAGANNCCCCCCTTNTNNNGAGAAGGCCTNTTTNNAATNCCGGATNAGGCAGAAAAAC TTNATTTGGATGGTTGGGNATGGTTNNNACTTTTGTCCNTTGANCTGGANNTTGGATGACC TTTCTAAGAACAAAAGGCNCAGGTTAANTTTNTGCCNAATTTNCATTCCCNTGAAACσSfG

AAAGGNAACCTTTTAATTNTGTGCTGGCCAAANATCCAAAAAANTTNCTTTTNAAANNAA TTANAAGGGGGGGANTTTNACCGGGNGGGGTTTTTAAAANTGGTN^ TTNTTTGGNAAANTAATTTTTTCCCCCGGANAAATTTTTTGNGGGGCGGGGCNN^ CCCTTTNTTTCCNNNAAACNTTTTNNCTTNNAAAANA^ TTTTTT< NNTTTTNCC(^CCCAAAN^

CCCGGGNCANGNCTANCCCCNGGGAAAAANGGGGGGCCCATl^TTTTTANTTNTCACNNN TTTTTTGT

TTNANAAAAGCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGG

CTGCAGGAATTCGGCACGAGGGCACACTGGCGGAAACGGAGGCTCGCTTCGGAGCCCAG CTGGCGCAGATCCAGGCGCTGATCAGTGGTATCGAAGCCCAGCTGAGTGACGTGCGAGCT GACACCGAGCGGCAGAACCAGGAGTACCAACACCTCATGGACATCANGACCCGGCTGGA GCANGANATTGCCACCTACCNAAACCTGCTGGAGGGCCAGGATGCCTACTTCAACGACCT GTCACTCGCGAAGGCCCTCTGAGTCTGGCGGCCTCCTGGCTTTCCCGCTCTGCTGCAGAAG

GAATTCTCCTGGGTAAGAGGCATGGGAGGGGAGGGACCCTTACCCTTGCCTCTCCCCCTG ACCTGCCAATAAAACTTTATGGCCCAAAGGAAAAAAANNATTNTGNAANNGNTNNNNAN ANNNNANNNTNNNNATNNNATNNNNNNNNNNN^ GGGGGGGGGGGCCCCCCCCATNTNCTTNANAGGGGNGGGNNNNAAAAANNNNNNNNNN NNNNNNNNNNNNNNNNNN^

NNNNNNNNNNNNNNTSINNNNNNNNN^ NNNNI I MSI ^ NNNNNNNNNNNNNNN^ NNNNNRWNNNNNNNNNNNNNNNNNNN^ NNNNNNNNTSINNNTSΠSINNNNNNNNN^

NNNNNNNNNN AAANCTGGACTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCAG GAATTCGGCACGAGGCAAGGACTTCACTGCCACCTTCGGCCCCCTGGACAGCCTCAATAC GCGCCTCTTCCTGCAGGGACCCAAGATTGCAGAGGAGTTTGAGGTGGAGCTGGAGCGAGG CAAGACGCTGCACATCAAAGCCTTGGCCATAAGTGACCTCAACCGGGCGGGCCAGAGGCA GGTCTTCTTCGAGCTCAACGGACAGCTGCGGTCCATCCTGGTCAAGGACACCCAGGCCAT

GAAGGAGATGCACTTCCACCCCAAGGCCCTGAAGGACGTCAAGGGCCAGATTGGGGCAC CCATGCCCGGGAAGGTGATAGACATCAAGGTGGCAGCAGGGGCCAAGGTGACCAAGGGC CAACCCCTGTGTGTGCTCAGCGCCATGAAGATGGAGACTGTAGTGACCTCGCCCGTGGAG GGCACTGTCCGCAAGGTCCACGTGACTAAGGACATGACGCTGGAGGGTGACGACCTCATC CTGGAGATCGAGTGACCACGCTGAGACTGGCAGCCTGACCATCCCCGCCCCTGCCTTCAG

GACACTGTGCTGCAGGGCAGGCCCAGGCCGGCCAGTGCCCGAGGCCAGGAAGGCCTTGG CCCTGCAGCTNCTGTCCGCGGCTTTTTACGGCANGACAGACTGGCTTGTGGCGGTCCATTT CCCCACCTTCCCACCCATTNTGTNCNTTTCCTTGCGGTCGACAAGTCGCTTCACGTTTTTCA TTCTTCCTGGCCAAATAAAAGGTCCCCTTCCTTTGCTTGGAAAACTTGCAAGTGGGCCCTG GGGCCCCGTGGGGAACCANACCTAGGGGGTGCTACCTCCTGCAGGGGAANAACCTGAGG

GCCCAGGTTGNAAAAACTTTGTTCAATAAAAAATGGGTTTCCCCNCCCTTCAAAAAAAAA AAAAAAAAAAAANNTGGGGGGGGGGCCCCGGCCCCCCTTTTCCCTTTTANAANN

GCCNATNNGGAGCTGCATCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGGNTAGTTTTTTAGGGTGATAAATACCACCCAAAACCCAAGCTGCCTGCAGCTCTTCC

TCCGTGGTCATCTCTCCTTCGCTTAGGTAACTGAACCTGCATTTTCCACCTAAACAAAGAC

ATGCCATTTCCTATAGCTGCTCAGCAGGCTGAGTTTATTTCAGACCCTTCCTCANAGGAAC AAAGGCCGGAGACACAGGGCTGCCTGTCACTCATTTCTTTTTGTTATTGNNGCATCCCCAC CCCTGCCCCCAGCAAAACTCACGCATCAAAAAAAAAAAAANNGTTTNTNTNTNTNTNGTN

TTNNNANTTTTTCNNGGNNCNNGGTTN^

NAAANTTTNGCTTTTTGGANGNCCCGGGCCAACTNCCCCCNCAANGGGAANGNCCCAAAA AGGGGTTNNTTTTAAANCTTNTTNTTTNG^ GNNANNCNNNGGNANNAGGNTTTTNAANAACCGGGGGGGGGNCCTTCTTTTTNTTTTNGA

ANGGNNGGGGGAAAAANCNNACCCCGNTAAANTNGATTTTI NGGGCCCCTANATTTTCC CCGGCGNGGGNNAACC⁽^TAGTNGGANNGGGGNNGATNCCCNGNCCCNATNTTNNNTAN CTNNGGGGN JNATAAAANQWTNΑSTGGNGNNAAAGGAAAAAAAATNTTCCCCNTTACCC GGGGGCCCGGGGGNTTTNNTCCTTNNNCAAANGGGNTTTTNTTTTNNT^^ CCCNTTANAAAAAAAAAATNTTNNAAGTGGNGGGGGGNNGGNGCCCANTCTNCTNTNAT

AAAAAAANAAAAAANCCCCTCCOSLNΑSFNGTGCCCCNGGGGAANNTNGTTTCTCCCAANC CCCTAAAAAAANAGG

TNCCCNATGAAGNGGN(^αSINNTNACNNANNCGCTNGCTTNAACTJSfCTTTNANGCCCNCA

TANNGGAGTNCGCATTACAGTGGTCNGTCCGCNCCTANAACTTGTGCGANNCCCCNNGGN CTGCNANCNNTCNGGNTGCTCTNGTCATNGAANANTGNCANGNCCTCTGCGCTNNGNNCA CTCNNTNNNATNTTA(^TTGCGGGNCTCTTTGTGTCCTNTACGNTNNTNTTNTGANGNGNT CNCC⁽^TTGAANNTNGNNTCTGGCNTAGGTNTNGNTNAGNNTTTTNTNNTTTCTCTNGNNC ANGC!NN(^CNNαSINNAGATATTTNCCCGNNANNNTTATNTAGNNAGGCCCN^

NTTCTCTNTTATGGANCTTNTNTCCANANGNNTNTACNAAATTNTTNANNTNTNGNCCNAA CNATTCCTN(^AGATNNTNTCNGGNATTTNTCTTGNNNTCTATCNNANNN^ NNCTANNANNACCNCCNCNGNCTCCCTTTNATNCTGGNAGCGCCCACANNAAANNGTGCA TTTGTTATNNTNCCTNNAGGCACTπ^ TGGTGNTTCTNCNNAGNTCTNNATNANNNANNANATNGCNNNANCTTGANCCTNNTTTNT

GNTTNGOSfNATNTANAAGNANNNCAATTNTNAATTACATNNNCCTAAAGNNGCCCTNCTT NNCAG<^ACCNNTCATISINNTTTANC^

NNNNTNNCTNNNNTAAATAATNGTTTCTTNATTNCTNOWGCN^ TCTTNCACCTNNπSTTTNN TATNCC<^(^GACAGCAANANCNATTGCATNCTGNNTTC3SπSfCCACGCGCTCTTAACCNAC

TACNN<^C^INNNGNNTCTTCTTO^

ANTTANTTCNGTTAANNCNNGNTTNTGCTGNTCANOSINGNGNGNCCTNTGTATCANCNNT GCGNGCTCNCTNNANCANCCCTNGNCANNAATTNCGTGNANNTACTNAATTCANCTCATC TNNACAGTCTCNTCTGNTTGTNTNCANNTATNNTNNANTGGNGAO^TGGGCNCCGNTCNT NCCCACTNATNG πS[NGTGTαsiNATCTCNTNTNTACCTNNNαvlNTGTCTNCNTπ

CATTNTNAANAACTCTGNNTCGTTANCNCNCCNTNCTACTATGCTNTCATCTCTNTGTTTC

NNGNNATNATNNCTCTTTCTTNTNCG

TTTGAGNCCTNNAGGGGANGTCGTAATTNCNNTGGAGNACNGCTCTAGAACTANGTGGAT CCCCCGGGCTGCAGGNAATGGNGGCACGAGGCAATATTNGTGAGCNTCTACNTTANGACN ATGNGTNCNAAGCGGGNNNATNCTTTANTGTGNT(^^ CAGGGCNTNACTNGTNCCNGATTGCTCCTANATNGGNACNTAANCNCGGCNCTACNANAC NCNCTTATTCTNAGNNA(^CAC(^TAGACAC^GTNGNNTNNNNTANNNNTANGNNNNNA

C^GACACNCNGTGAGGCTCNTGNNNAGTTNACNNCCNCTNCTCTTANAANNANTTCTTNN CCTGNACAANNNNCAGNAATCNTTNTNGTTNAAANNNAGTAGCNNNTCMsfATNTT^ TCTCTTTCNTCTTGCTNTANGACTNAAAAAANCCNNNAGNTTNAANACNCANACAGNNAC NANNNNGCTTTTNTANAGANNCANNNTNCGCGACNTGTANGNTNTGNNAAATNGNCGAN AAATTNCNNGNCGNCANGCACNACTNTTIT^NNTTTTTCANTTCCCGGTNA^

TTTNCN(^CTCACTNACTCNNTCACTTNNCNANCNACT(^AGTANNGNCAANCGNCNNTC TTGNTNCNCNNACTTATATNTTCNANNNANNAACANTNTNCNTCTACANTNNTNNCTNGT CTGNNATNCATACGCNAGNGNNCATCTNNNGCNNGTCNANTATNNACCTNTCGNCCCNCT AGANNGTNCNCGATN(_ ANCATNANTTNNAT∞ NNNNNGNTNCC<^TGNC CTNNNAGTTCT

NTTACTACNNGTNNNANAGTTGANANTCNANANGNNNCANCGTNGNCGTCTCGTANAAT GGNCKNNNTAATTCNCNTNACTANGTCNNANGCTCTCCGNGTACNGCNATACATGTACAN TTNNNTCNNGNNNAGCGGNCCNNTNNTNTACTCTCCTNACTANNNNNANGTTANC NGTACAACNCGNTNGACNTTNNTNNANGTATGAAGANNNNTGTNTTANNANNNCGTGGA TNCTCNANGATTATNCCTANTCAANTAGNTCTNCNCNNCANGANCCANAATNNNNACNCA

NCACGTATGTCANNNt-MSINTGTACGANt^AGGNCJsINACCCGTNGNNTNTCNCACGTNGCT NTCATNCG

TTTGAGNCCTNNAGGGGANGTCGTAATTNCNNTGGAGNACNGCTCTAGAACTANGTGGAT

CCCCCGGGCTGCAGGNAATGGNGGCACGAGGCAATATTNGTGAGCNTCTACNTTANGACN ATGNGTNCNAAGCGGGNNNATNCTTTANTGTGNT CAGGGCNTNACTNGTNCCNGATTGCTCCTANATNGGNACNTAANCNCGGCNCTACNANAC

N(^CTTATTCTNAGNNACNCAC(^TAGACACNGTNGNNTNNNNTANNNNTANGNN^ (^GACACNCNGTGAGGCTCNTGNNNAGTTNACNNCCNCTNCTCTTANAANNANTTCTTNN

CCTGNACAANNNNCAGNAATCNTTNTNGTTNAAANNNAGTAGOSπSINTCNNATNTTCTNAA TCTCTTT( NTCTTGCTNTANGACTNAAAAAANCCNNNAGNTTNAANACNCANACAGNNAC NANNNNGCTTTTNTANAGANNCANNNTNCGCGACNTGTANGNTNTGNNAAATNGNCGAN AAATTNCNNGNCGNCANGCACNACTNTTTNNNTTTTTCANTTCCCGGTNAAA TTTNCNCNCTCACTNACTCNNTCACTTNNCNANCNACTCNAGTANNGNCAANCGNCNNTC

TTGNTNC^OSINACTTATATNTTCNANNNANNAACANTNTNσSfTCTACANTNNTN^ CTGNNATNCATACGCNAGNGNNCATCTNNNGCNNGTCNANTATNNACCTNTCGNCCCNCT AGANNGTNCNCGATN(^AANCATNANTTNNATCGTGGTANTOSINNNATαsπ^ NM<^GNTNCCCNTGN<^TCT JN^^ NTTACTACNNGTNNNANAGTTGANANTCNANANGNNNCANCGTNGNCGTCTCGTANAAT

GGNOSINNNTAATTCNCNTNACTANGTCNNANGCTCTCCGNGTACNGCNATACATGTACAN TTNNNTCI^NGNNNAGCGGNCOWTNNTNTACTCTCCTNACTANNNNNANGTTANCNCT^ NGTACAA(^CGNTNGACNTT^WTNNANGTATGAAGANNNNTGTNTTANNANNNCGTGGA TNCTCNANGATTATNCCTANTCAANTAGNTCTNCNCNNCANGANCCANAATNNNNACNCA NCACGTATGTCANNNCNNNTGTACGANCNAGGNCNNACCCGTNGNNTNTCNCACGTNGCT

NTCATNCG

TNNAGCNCNATCNGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGGTGACTATTCTCAACCAACCATAAAGATATTGGTACCC

TTTATCTACTATTTGGGGCTTGGGCCGGTATAGTAGGAACAGCTNTAAGCCTTCTAATTCG CGCTGAATTAGGCCAACCCGGANCTCTGCTCGGAGACNACCAAATCTACAACGTAGTTGT ANCCGCNCA(^CATTNGNAATAATCTTNTTCATAGTAATNCCAATCNTAATGGGAGGATN CGGTAN(^GACTTGTNCCCCTAATAATNGGGGCTCCCGATATAGCATTTCCCCNAATAAAT

I AATATAAGCTTCNGACTCCTCCCTCCNTNATTCNTACTACTCCTNGCATCCTCTATAGTTGA AGCTGGGGCAGGAACAGGCTGAACCGTGTNCCCTCCCTTAGCAGGCAACCTAGCCCATGC NGGAGCTTCAGTANATCTAACCATTTTCTNTTTACACTTAGNAGGAGTTTCCTCANTTTTA GGAGCCATCANTCTTCTTTACAACANTTATCAACATAAGGCCCCCCGGAGGGNCACAATA CCAAACCCCTTTGTTCGTAAGANCCGGAAANAATTACCGGGCGGANTANAANTACTTTTC

GCTCCCGTGGAATNAGCAGNCCGGGCATCCACAAGTGNTTTTTAACAAGCCCGGGAACCC TAAAANACCACCCTTTTTTCCACCCCGGGGNNGGANGGAGGAAANCCCTTNTTTTTATTAT CAACC(^TTTNTTNTTGAATTNTTTTC

NNCCCNGGGGGGNNNGNAAAAAATTTTTTTTATTTTGGGGGNCCCTCCCTTCCTGGGGGA AAAAAAAAAAACCCCTTTCCGGATTTTTTGGGGAAANAGGGNGGGGGCCTAAAAAGGGC

AAAACCGGGTTTTNT

TTNANCNCNATCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGNNACGAGGCTNANCNATACCGTNGACNTCNNGGGGGGGCCCGGN

ACCCAANTNNNCCTATAGTGNNNCNTATTNCANGNCCNGNNNAOsINNGCTTNNNCNNCA GGGTNTGTCTNNCCANTTGGNNCNAGANNACNTGNGCATTGCAGCTCAGGACTNNACNGG TTMSTGAAGGTNACATNNGNATNATTNACCTTTAAAATNANTCNTGCNCTCATGGCTNT^ TNTNTTGGCTNTTGCCCCATNTGATGANCACTNTTANGTGNNTNACCTTGNACCTGATCAN TGCTNCCCNCTNNTNAATGαsrTTGCTTCNTNACANNTGACAGNACTTACAACATTNTNTAA

CTGGNTCNACCCGNNTNANTNANAAAAGAACTNGTGNTAACCATTTTANAAATCCANGTC ACCNNNCTATNTNAGNGATNNATGTGTATNNGGAAANGATCNNTACATTATCAANTGATN AGAAGCCCTGTNTNNCAATGNACATTNTACNTNATTNTTTAATATGNNGTACNATAAAAT TTTAACATTTGGCGGAI^TTGACTGCTTTGTTAATGATTTGCNGGGGGGNNNNNGCACNCC TTTTGGNGGGGNTSIGNNCGGGGGCCNAANTTNGNCNTTTTNTGGGGGNNCNTNAAANANN

NNNNNNNNNNNNNNGGNGGNNTNNCNCN^ NNCCCCTNCCCNNTTTTGGNNNNNN^ NNNNNNNNNNNOSINNNNTTCCNNNNNTNT^ CNNNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNTNNNTTNNNNNNNC

TTNNNCNCTATCTGGAGCTNCACCNCNGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGAATTCGGCACGAGG(^(_^FNNAATNCNTNTNNTAGNTGTNTGGANNCACAN GCCGGNCCTNNATATCNGTTCACCANACTGTGANTCATNAACACNAAGCTTTCTNCCTAG

GTTTTNTAATGGCΉ^ATTTCGAATTAGANNAGNCTGTGGNTTGAACTGCANGACTACAGAG GTTGNGAAAATCACAGTNACNTNANCCCCCNAGAAGNGCATCCCCCCTCTCNTGNCTCAA GTCTGNCTNGGCTGTTCGCC(^ATCGTTGAACACTTTTAAGGTTCTGNCCTTGCNCCTGGN TCACTGNTACCCCTCNCTTAAATNATTAACCCTCCTGAGAGCTCACAGNTACTCGTTGATA TNTATACCTGGNTTNACCAAATTGAATGAAAANGGANCTTGTGCAAANAATTTAANAAAC

CGNTNTCACNACGTNTTGTAAGAGAT(^CTGTAATNGGGAAANGTCCTTTACTTTATCAAT TATGTAAGGCTTTTCTATATCGAATGGNCCTTNNTNCANATCATTCATATGGNGANCANAA AATTTTAAAATTAANGGGACTTGACTGNTTTTGTNAANGATTTCCANNNAAAAAAAA^ AAN(_^TTGGGGGGGGGNGGCCGGNNCCCCCCATTNCCCCNNTNTTNGGGGGNGNCNNNA ANNANI NNNNAGGGGGGGGGGGGGGGNTTTTNTTNCC^

CCCCCCNCCCCC ΪNNNC^TTTTTTNA^ NGGAAAATCCCCCGN 1NNNNNAN]NINNTTTT^^ AAANNNNGNTCTTTTNNCNCGTNTNN^ GGGGGGGGGNNCCCCTTCCNTGGNCCCNTC

ANCAANAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGC TGCAGGAATTCGGCACGAGGGGTGGCTGGAGATGGTAGTGGAGAGGGGAGTGTGGGTTTT GGAGTCGAGCAGACAAGTATAAACCCTCATCCTCTTGTTACTCGTAGCTGCTTCCTGTTGT TGTAAAGATTAATGACATCATGTGAAGCACCAGCACACCATCATCATAACAACAATATCT

AACTTTATTTAGCCCTATAGTGAGTCGTATTACANNNNNNNNNNMSπSIN^ TNNNAANNNNNCNNNNNGNTGGNNNGTNNNNNOSINT^ NNO NTGNNNNNATNNTNNANCNNNNNNN^ CINNNNNANNCNNINANNNNNN^ NNNNNNNMSINNNNNTNNTNNNNN^ NNNNNNNNNNNNNNNNNNNNτlNNNT^^ NNNNNNNNNNNNNNNNNNNNISINNNNN^ NNCNNNCNNNNNNCMNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNTNNNNNNNNNNNN^

NNNNNNNNNNNNNNNNN^ NNNNNT>JNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNANNNNNNNNNNNNNNNN^ NNMNNNNNNNNNNTC

AAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTGCA GGAATTCGGCACGAGGCTTGAAGATCAGCCGCCATCATGAACGACACAGTAACTATCCGG ACTAGGAAGTTCATGACCAACCGACTGCTTCAGCGGAAACAAATGGTCATCGATGTTCTT CACCCTGGAAAGGCAACAGTACCTAAAACAGAAATTCGGGAAAAACTGGCCAAAATGTA

CAAGACCACACCAGATGTCATCTTTGTATTTGGGTTCAGAACGCATTTTGGTGGTGGCAAG ACAACTGGCTTTGGCATGATTTACGATTCCTTGGATTACGCGAAGAAGAATGAGCCCAAA CACAGGCTTGCGAGACATGGCCTATATGAGAAGAAAAAGACCTCACGAAAACAGCGGAA GGAACGCAAGAACAGAATGAAGAAAGTCAGGGGGACTGCAAAGGCCAACGTTGGTGCTG GCAAAAAGTGAGCTGGAGATTGGACAACAGAAGGAGTAAAGATTCTGCAGTGACTGTAT

CTGTGGTGATTGTGCAGATTTTTCATGAAAGAGAGAATAAACTAAGACCTTTTACAAAAA AAAAAAAAAAAAACCTNGNGGGGGGGCCNGNTCCCNATTTCCCCTTATAGNGAGNTCGN NNTNANNNNNNNNNNNNNNNNTNNNNNN^ NNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNCNNNNNNNNNNNN^

NNNNNNTNNNNNNNNNNNNNNNNNNNN^ NNNNNC^CNTNTNNNNNNTNNNNNN^ NNNNNNN πSINNNNNNNNTTNNNNNNσS[GN^

GCNCGNNNTCCNNNNTACTTTTT^

NATNTTCAANTTNANNTCTACNTNTNNTTCTTCNGTTGGCGTNCGGTTATNTGGCCTTCNC CTTTGANNCCTATATGGAGTCGTATTACAGTGGCGGACNNTNTATCAACTAGGGGGGATC CCTCCNGGCTTTCACNATTTCTNTNTATNNANNNT(_MSfTTACCACCCATAANCCCNNGNCN NlSπ^TTANNANCTTT(^GGCTNTTGANTCACCTTTAATTTCATTCCCCNTNAA

ACTAAGNCCTNNCG(_MTTCNCGNGNCTTAANTNCTTNNTTNTTCNTCCCTTCCN^

NANTNTGACACTNTNNNTNGNNCCAGNCNTNTCANTNNTANTTCTNTTATNCACACNCGC

NNNNCTNTTGOWGTNTNANTCTATNTO^

CCTNOSINNATISπsrTACTNT^ CCAGACGNTACNATTNNCTCNANTATTTTTGNGCTCC^^

ANNTGNCTGACNCCCTNAGACNGTNNATATNACTTNATTTNNTTNNNNTT^ CANNNNNGATACTCGTATCNCATTGTNNACCNNTNCTNNNACTGTANNCATTTNNCTANT TNNGNTTTANANNANATNNCTNTNCCAG CAGNNTCCNNANATCATTATTAGN(^ACTANNANTCNTCCATANNAATNCTNTTATTTTAC TTGACTCTCTTTNAN(^GATANTTNCCNTNCTANNTNTCTTTTANACCACTCCTNTGNCNC

NATNANCTCTTTNAA(-OTACTNCCCGTCGTCT^^ NATTTTGCNNTNANCCCNNNTCCTNAC^

TCCTATGACTCNNNANNAGGNTATCNTCNTATGTNTNTNTGATNCTTCGTAATTCNNTCGG NTNNCTNCTNNTNCGTTTNTTTNTTTGTANTGNNNNTTTCNTTCT^ NTNCNGTNNCTTNfNTNGNNNC^^

NACNCATCGATCTCTCTCACATATNCTTACNATCGANAANTTATANTCNNTCTTGTTAGTC ANNTATCATNTCTNNNCNNNANNNTNNATTNC^CTCTTAGCTNTNNACTAAGCGNGAN^ CNTANATANGNTNTATCTCATNAAOSICCTANCGTATATTNGCTCTCTCCGTNACTCCAACT OSfTCTAATNCGCGCTNNCTCCNCGACANACTTATGCTCTATCCATTCCTCACANTAANCAT NTGTAT(^TATCNANGGNTGCNACGACNANANANNATTGNCTGTNNTNNTCATCNACGCA

CGCTCTNCTNCCTACGNTNGTTNACGNTCTNNATCAANCTCNCCTANCTNTNTTCCNNTCT CTACTTATGNGATCCTNCNCGATTTANC(^(^CCGTGTGTATGCNAGNCTCTTNNGTGATA NATACGNNCCCTCTNATCCNCTATNCGATNTCCG CTCGACNGNNGCGGGGTNGGCCNGGTGANCNGCTCNTGACNCCCTNTNCAGCCCTCATAG TGGAGTNCGTATTACATNNNAGGNCGATCCCTCNGGCTGCGTNTCCCNCANGCCCNNNNC TCCCTNNGGNGNTGOSINTNN^ CCTTGNOSπ^JNNTGGNGNNNCATNCANATNTTTTTNCGCTNTCGTNCNANCGTCG

ATNGGNCGTAGNGNNNCCGGGGNNGNGGCCGNTCCANCNCCCGCTTATNNCNTNGGGAN

NCCACCC^αsrCGTNOSINCαrc^

(^GNTGTNlNINCTCTISπsrTN^

NNTNTN(_^ACGCATGNTNNNCGTCCGCNNGTCCCTCTNNNNNGNNNCTTNTN^ CNNTNTTTTCTACGTANTTGGTCGAGGNCGNNNNNNCCACTCαS[TGCTGTTNCCTNGGNG

NNGANGNGCαSTGGCTTCTNTCCTGTNTTNTCNCTCNNNCCTNCGTCTGANCCHNGNTTT^ CNTαrcACTGTNNGTTTAGNGCCGGCNNG

CGNGGCNNCNTCGATNNATTNNCTTTCANNNCTNTCATCCCCACAANCNN^ NAOSINNCTCTNTCCCNTATCCNCTC^ TTNTATCTT(^TANCTTTCCCTATNTCCCGTNNNNCCTCCNCNNATNT JNCCGCGCATNGN

TCNCTCGTGNNTTACATCNNNCCNTCTGGTTGCTCCNTOSrGANGATNCNTTAACNCTTNCT NCGTGNTCGNOSπSfCNTNCTTNCNATNNTNTAOS[GCCGNCTGNNCGNNATTNACTGNGNTC CCG(^GGNOS[ATTNNTNCNTTTCATCCTTNNNATTTCTTANTNCNTNTAC^^ TNGTAATCAGCTANCCCTCAANGTGNCCTCTNTCTCNNTNNNNTNCGNCTGTCTNGGCNNC NTCATATGNTSTNTNTNTNTNNCNNTCGANTNCTCNCACNTTCGTNCNTGCTTCCGCGNGTNC

NGAGCGAOSriTCGTTGNTCNGTNCCCCCNCT(^GTTαsπNTCCTGANGNGNGTGNCNCNNN TGTNTNCTTNCTTTCTCTNCGTATNTTCTCNNTCGNCACNNCTCGNNGNCGNAGCGANAGN ACTGNNCGTNANANCTAGTCNNNCTGNGCAACTGANGNACNGCGTNATAGTCNTATGCCC GCGNTNNGNGNACATCTNTCTGNNCNTTNNOSfNATNTGNNNNNGCTNNNANGTNT^ CTCGCTCGANNTNNTCACTNCGACGCGCGGTCGTCGCTCCGACNCATNNTCTGTNTNNAA

NGGNTNNNTCNANCTNNNCACG

GCCTATNNGGAGCTGCACCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCCGGGCT GNAGGAATTCGGCACGAGGCAGAGTTGTGGAGTTACAGAAAAAAGTNGTCCAGCCCACA

AAACATAANGTGGTTNACTATGTGNACCCTTNAAAAAGGGTCANTGGNNσsπSTGNCTTNAA NGGGCCNNANTNTGGGGNNTGANCNNNCCNANCNGANNTNANCNAAGGGGGGGNTGGT NATTTAAGGAAATGAAAAAGNANGA(^AGNCACTTACNGGCCCTTTAANCNCTNTNACTG GNCNNGGCNNANNCCATGGNCACCCCAAGCCCANGGAGTGTGANCCTTNCGCGTGCCTTG GAAGAGAANCCNAGATATTTGGAAGACGATACTACCCCTAACACATATGCTGTGTTTTCT

CTCTCTACANAATTTTTTTGAAAAGATTTTTTCTTTTTAAT^^ GTAAAATGCGNAGACNTAAGTGCNCACCNTGTNNATTTTATGTGCNCCCTATACCCNTCN

CCCAATCAAGACACTGGACGCTTTCACACCCTGGTGACTGTNCCGCTATGCACACNCGCA

GCCTGGNACAAATAACACTGGTGTTGANCGTGTTAACAAGAGATATGTTTGGTNTTAAAN CCTCATTGTAAAAAATACTGGGGACTCTTGCTCACAATTGTTCTGGGAGGTATTCNTNGTG

GGGATCATTTATTAATACCCCCTTGNGGGGTCTGGCATGGNGACTTAAAACACNGCTTATG AANACNTTCCTACTGGTNGGNGGGAAATTTGGGGGTGGGNGCCANCTTGTNNGTTGGTTT TNAATAAAGNNCCTCCNAACCNCCNNNNNNNNNNINΠSINNNNNNAA^ GGGGGGGGGGGCC(^ANTNTTTNNCTTTAANNNNGGG

GCCTATNNGGAGCTGCACCNCNGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCCGGGCT GNAGGAATTCGGCACGAGGCAGAGTTGTGGAGTTACAGAAAAAAGTNGTCCAGCCCACA AAACATAANGTGGTTNACTATGTGNACCCTTNAAAAAGGGTCANTGGNNCNNGNCTTNAA NGGGCCNNANTNTGGGGNNTGANCNNNCCNANCNGANNTNANCNAAGGGGGGGNTGGT

NATTTAAGGAAATGAAAAAGNANGACNAGNCACTTACNGGCCCTTTAANCNCTNTNACTG GNCNNGGCNNANNCCATGGNCACCCCAAGCCCANGGAGTGTGANCCTTNCGCGTGCCTTG GAAGAGAANCCNAGATATTTGGAAGACGATACTACCCCTAACACATATGCTGTGTTTTCT CTCTCTACANAATTTTTTTGAAAAGATTTTTTCTTTTTA^ GTAAAATGCGNAGA(^TAAGTGCNCACCNTGTNNATTTTATGTGCNCCCTATACCCNTCN

CCCAATCAAGACACTGGACGCTTTCACACCCTGGTGACTGTNCCGCTATGCACACNCGCA GCCTGGNACAAATAACACTGGTGTTGANCGTGTTAACAAGAGATATGTTTGGTNTTAAAN CCTCATTGTAAAAAATACTGGGGACTCTTGCTCACAATTGTTCTGGGAGGTATTCNTNGTG GGGATCATTTATTAATACCCCCTTGNGGGGTCTGGCATGGNGACTTAAAACACNGCTTATG AANACNTTCCTACTGGTNGGNGGGAAATTTGGGGGTGGGNGCCANCTTGTNNGTTGGTTT

TNAATAAAGNNCCTC(^AACCNCCM<JNNNNNNNNNNNNNNNN GGGGGGGGGGGCCCNANTNTTTNNCTTTAANNNNGGG

TTNNANAAAAGCTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCG GGCTGCAGGCAGGATCAAGCGATTCCTGGCCAAGAAACAAAAGCAGAATCGTCCCATTCC TCAATGGATTCGAATGAAAACTGGCAATAAAATCAGGTNCAACTCCAAGAGAAGACATTG GAGAANAACCAAGCTGGGTCTATAANAAGCANGCTGGGTCTATGANAAGNGGNCTTANC ATGTANACCACTTTTTTANGCAGCCAGATCACAATGAAANCATCACTACTGTAANGCTNG

GCCCATGATGTTATTTCCTCACTATCAGNCTGAGACCCANCATTAANTATAAANCGTNGCA AAAAAAAAAAAAAAAACNTGGGGGGGGGCCCGGNCCCCAATTCCCCCTTATNGGGNGTC GATAANAANNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNN^ NNNNNNNNNNNNNNNNNNNNNT^NNN^

NNNNNNNNNNNNNNNNNNNNNNTSINNN^ NNNNNNNNNNNNNNNNNNNNNNNNNNNr^^ NNNNNNNN^rNNMNNNNNNNNNN^ NNNNNNNNNNNNTSINNNN^ NNNNNNNNTSΠSINNNNNNN^

NNNNNNNNNNTSINNNNNNNNNNNNNW

ANANCTGGAGCTCCACCGCGGTGGCGGCCCGCTCTAGAACTAGTGGATCCCCGGGCTGCA

GGNTTTAAATCAAGTCAACCCTTTTCAAAGTAAAGAGTTCACACAACTACTTTCATGAATT TTTTAATCCCGTTGGAAACATATACCAGGAGTGTTCCAGTATACTGGAATACAGGCACACT ACCATTCATGGTATGAATΓCTGGGGTTTACACAACCAGTTTTGATGCAATCTGCTCAGTAA TATAATTTGTCATTTTTATTAGAAATATAATTTCTTCATGTGATGTCATGAAATTGTACATA CTGCAGTGTGAATΓTTTTTGTTTTGTTTTTTAATCTTTAGTGT^

GAATAAATGAAGGAAAAAATTCAAAAAAAAAAAAAAAAANACNCNGGGGGGGCCCCGG ACCCAAATCCNCCNNAANGGGNGGCNTNNANAANNNACAAGGTGCGGCACCTGGAGCAC ANAACAAGGTTCTGGANACCAAATGGACCTNCTGCACACANAAGACTGCCCGGACAACA TAACAACATGGTTTGANAACTNCATTAACAACCTTCNGTNGGNAGNTGGAAACTCTGGCC CANGAAAAACTTAAACTTGGAAAGTGGNNCTTGGCAACNNNCCAGGGGCTGGGGGGAGG

ACTTCNAGACCCANGNTTNNNGGNNNNAAATCCNAAANCCCCCANACNTNGGANAAATG AANTTTNN^WTTCNTNNAAAAAGGGTNNNGGNTNAAACTTNNCNTN^ <^TGGNNNCCCCCCΑWGNAANGGGNNT^JN^^ NANNTNTTTTNAAAAAAANNAAAANCCNNGNNNA^ CΑSFNNCCGGGGGNCCNTNNNCNNTGGNNNAAAAAANCCNNNNNNCNTTGGNNCNNGG

GCCTATCTGGAGCTNCACCNCNGNGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG CAGGANTTCGNNNCGNGGGTTCACTTTNCATAGTAAOSπsiGGNCACACCATTAGGTTTCAT GTATCACATTTAACCANGNCAGGNNACATNTNCCATGGGNCGNTCCAGCTTACTNGGATT

ACAGGCA( NCTACCATTCATGGCATNAGTCCTGNNTTACNANCAACCAGCTTNNNTGCAT GCCNTGCAGCCATATNTTTGCNGCNTTATGATAACCAAAGCNTAGCCNTGTCAATGGGAT GNCTTGAAATTGNNCANNCTGNTNCGGTGANTGTNTTTCGTTTNNANTTTGANCTTGTT^ CAGAATAACTCACCTGCATGGNCTCNTNACTANATCNACTGANAGAAANCTTGAGAAANA TAACCTTTCTNCTGGGGGGGNCTCCCCNTGCCTCTAAATCCCTTTAATGGCNACCGTCCCC

CTCAGGCNCACCNTGGNGACCTGTGACANAGGATTTTTCAAAATTACNCCCCTCCTNTGTC CCAGGCCCCANACTTTNTCCAAGGGACAACAGCAAACCAAAANTGCCATNCAAAGGTCCA NCANCCTTTTTGCCCCCATTTTCCCACTTTGCCATTGGGGNGCAAGTTTGCCTT^ C(^CAAAGTNGGAGGGAANTNGGAAATGGGACCAACTTTTTACNATGGGANTAAAAACG GTTTTTTNTAACNAAANANAACCCC1TTCCCAAAAGGGGGGGNTTTNTNGGGNGGGGGCC

CTTTNTTTTTTTCA^GGNAAA^ GGCCTTTNTTTTTTTTNNNTTTTACCCCNT^ CCTAAAGGGTAAAACAAACCTC(^GTTTTGGGNCCCCTTTGGAAAAAANCCNGGGGAAGG AAT

ANCAANNCTGGAGCTCCCCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCCCCGGGCTG

CAGGAATTCGGCACGAGGCTGAGAAGCCANATNCTAAGGAGAAAAAACCTGAAGCCAAG AAGGCTGATGCTGGCANGAAGGCTAAAAAGGTGGANAAGGTGAAGAAAGTNNANAAGG GGAAGCCCCACTGCAGCCGANATCCTGTCCTGGNCAGAGGAATTGGCAGATATTCCCGAT CAGCCATGTACTCCAGAAAGGCCTTGTACAAGAGAAAGTNTTCAGCTGCTAAATCCAAGG T(^AAAAGAAAAAGAAGGTTCGNGTTCTTGCTACTGTCACAAAACCATTTGGTGGAGACA

AGAATGGTGGTACCCGAGTGGTCAAACTTCGCAAAATGCCTAGGTATTACCCTACTGAAG ATGTGCCTCGAAAACTGTTGAGTCATGGCAAAAAACCCTTCAGTAAGCATGTGAGGAAGC TGCGTGCCAGCATCACTCCTGGGACCATCCTGATCATCCTCACTGGGCCGCCACAAAAGG CAAGAAGGTTGNTTTCCTGAAGCAGCTTGGGCAGTGGGCTTTGCTACTTTGTGAACTTGGG CCTNTTTTCCCTCAATCGAAGTTTCTTTTTGNGTANAAACACACCCAAAAANTTTGTCAT^

GN(.HNCCTCCCNCCAAAAATCGATATTCAGNGGGNGTGAAAAATNCCCAAAACATTTTCA CTTGACNCCTTA(_^TTTAANAAAAAAAAAAAGCTTTGGTTNAANCCCCANACCCCCCGGG NGGGGCGANAANTCTTTCCNCCCCCGGNGGNGGNGGGGNAAATTNCCGAGAATNCCCCN NNNCCCNCGCCAANGGNTCCAATANAAAAAAAGCTTTTNGGACCTTCCCNAAAATTTTTT GGGNAAAAAAAANAAAAAAAGGTTTGNCCCTTTAAAATTTCCAANGGGGGTTAACCTTTC

GGGTTNCCCNGNGNTTTGGN

Claims

CLAIMSWe claim:

1. An expressed sequence tag ("EST"), wherein said EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of which, or its complementary sequence, in a cell identifies said cell as a developmentally competent cell.

2. An expressed sequence tag ("EST"), wherein said EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of which, or its complementary sequence, in a cell identifies said cell as a developmentally incompetent cell.

3. A gene expression database comprising: two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of wliich, or their complementary sequences, in a cell identifies said cell as a developmentally competent cell.

4. A gene expression database comprising: two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, in a cell identifies said cell as a developmentally incompetent cell.

5. A gene expression database comprising: one or more first expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of one or more genes, the expression of which, or their complementary sequences, in a cell identifies said cell as a developmentally competent cell; and one or more second expressed sequence tags, wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of one or more genes, the expression of which, or their complementary sequences, in a cell identifies said cell as a developmentally incompetent cell.

6. A gene expression database according to any one of claims 3, 4, or 5, comprising at least 10 different ESTs.

7. A gene expression database according to any one of claims 3, 4, or 5, comprising at least 100 different ESTs.

8. A gene expression database according to any one of claims 3, 4, or 5, comprising at least 1000 different ESTs.

9. A gene expression database according to any one of claims 3, 4, or 5, comprising at least 5000 different ESTs.

10. A gene expression database according to any one of claims 3, 4, or 5, comprising at least 10,000 different ESTs.

11. A gene expression database according to any one of claims 3, 4, or 5, wherein ESTs are obtained from the same species as said cell.

12. A gene expression database according to any one of claims 3, 4, or 5, wherein said cell is a mammalian cell.

13. A gene expression database according to claim 12, wherein said mammalian cell is an ungulate cell.

14. A gene expression database according to claim 13, wherein said ungulate cell is a bovine cell.

15. A method of identifying an expressed sequence tag ("EST"), wherein said EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of which, or its complementary sequence, identifies said cell as a developmentally competent cell, the method comprising: comparing one or more first nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to one or more second nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; and identifying a nucleic acid molecule present in said first nucleic acid molecules that is not present at a detectable level in said second nucleic acid molecules.

16. A method of identifying an expressed sequence tag ("EST"), wherein said

EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of which, or its complementary sequence, identifies said cell as a developmentally incompetent cell, the method comprising: comparing one or more first nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to one or more second nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; and identifying a nucleic acid molecule present in said second nucleic acid molecules that is not present at a detectable level in said first nucleic acid molecules.

17. A method of preparing a gene expression database comprising two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, identifies said cell as a developmentally competent cell, the method comprising: comparing a first plurality of nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to a second plurality of nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; identifying two or more nucleic acid molecules present in said first plurality of nucleic acid molecules that are not present at a detectable level in said second plurality of nucleic acid molecules to provide two or more identified nucleic acid molecules; and combining said identified nucleic acid molecules in a gene expression database.

18. A method of preparing a gene expression database comprising two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, identifies said cell as a developmentally incompetent cell, the method comprising: comparing a first plurality of nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to a second plurality of nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; identifying two or more nucleic acid molecules present in said second plurality of nucleic acid molecules that are not present at a detectable level in said first plurality of nucleic acid molecules to provide two or more identified nucleic acid molecules; and

combining said identified nucleic acid molecules in a gene expression database.

19. A method of preparing a gene expression database comprising one or more first expressed sequence tags ("ESTs"), wherein said EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of wliich, or its complementary sequence, identifies said cell as a developmentally competent cell, and one or more second expressed sequence tags, the expression of which in a cell identifies said cell as a developmentally incompetent cell, the method comprising: comparing a first plurality of nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally competent nuclear donor cell to a second plurality of nucleic acid molecules obtained from one or more embryos produced by nuclear transfer using a developmentally incompetent nuclear donor cell; identifying one or more nucleic acid molecules present in said first plurality of nucleic acid molecules that are not present at a detectable level in said second plurality of nucleic acid molecules and identifying one or more nucleic acid molecules present in said second plurality of nucleic acid molecules that are not present at a detectable level in said first plurality of nucleic acid molecules to provide two or more identified nucleic acid molecules; and

combining said identified nucleic acid molecules in a gene expression database.

20. A method according to any one of claims 17, 18, or 19, wherein said comparing step comprises comparing said first and or said second plurality of nucleic acid molecules to a reference nucleic acid library obtained from an animal ofthe same species as said developmentally competent or said developmentally incompetent nuclear donor cell.

21. A method of producing one or more animals by nuclear transfer procedures using a competent nuclear donor cell, the method comprising:

(a) performing one or more nuclear transfer procedures to provide one or more nuclear transfer embryos;

(b) culturing each of said nuclear transfer embryos to provide one or more embryos comprising at least two cells; (c) separating at least one cell from each of said embryos to provide one or more isolated embryonic cell populations;

(d) determining the developmental competence of each of said embryonic cell populations by comparing one or more nucleic acid molecules obtained from each of said embryonic cell populations to a gene expression database, whereby said comparison identifies those embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell; and

(e) implanting embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell into one or more recipient females for development into said one or more animals.

22. A method according to claim 21, wherein said one or more animals are one or more mammalian animals.

23. A method according to claim 22, wherein said one or more mammalian animals are one or more bovine animals.

24. A method according to claim 21 , wherein said nuclear transfer procedures comprise using a transgenic nuclear donor cell.

25. A method of identifying a developmentally competent nuclear donor cell line, the method comprising:

(a) separating one or more cells from a cell line to provide one or more separated cells;

(b) performing one or more nuclear transfer procedures using each of said separated cells to provide one or more nuclear transfer embryos; and

(c) determining the developmental competence of each of said nuclear transfer embryos by comparing a plurality of nucleic acid molecules obtained from each of said embryos to a gene expression database, whereby said comparison identifies those embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell.

26. A method according to claim 25, wherein said method further comprises culturing said nuclear transfer embryos prior to determining the developmental competence of each of said nuclear transfer embryos.

27. A method according to claim 25, wherein said one or more animals are one or more mammalian animals.

28. A method according to claim 27, wherein said one or more mammalian animals are one or more bovine animals.

29. A method according to claim 25, wherein said nuclear donor cell line is a transgenic nuclear donor cell line.

30. A method of producing one or more embryos by nuclear transfer procedures using a competent nuclear donor cell, the method comprising: (a) performing one or more nuclear transfer procedures to provide one or more nuclear transfer embryos;

(b) culturing each of said nuclear transfer embryos to provide one or more embryos comprising at least two cells; (c) separating at least one cell from each of said embryos to provide one or more isolated embryonic cell populations; and

(d) determining the developmental competence of each of said embryonic cell populations by comparing one or more nucleic acid molecules obtained from each of said embryonic cell populations to a gene expression database, whereby said comparison identifies those embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell.

31. A method to assess the effect of one or more changes in a nuclear transfer protocol, the method comprising:

(a) performing one or more nuclear transfer procedures according to a first nuclear fransfer protocol to produce one or more first protocol nuclear fransfer embryos;

(b) performing one or more nuclear transfer procedures according to a second nuclear transfer protocol comprising one or more changes to said first nuclear transfer protocol, to produce one or more second protocol nuclear transfer embryos;

(c) determining the developmental competence of each of said first protocol and second protocol nuclear transfer embryos by comparing a plurality of nucleic acid molecules obtained from each of said embryos to a gene expression database, whereby said comparison identifies those embryos; and

(d) assessing the effect of said one or more changes by comparing the developmental competence of said first protocol nuclear transfer embryos to the developmental competence of said second protocol nuclear transfer embryos.

32. A method according to claim 31 , wherein said method further comprises culturing said first protocol nuclear transfer embryos and/or said second protocol nuclear transfer embryos prior to determining the developmental competence of each of said nuclear fransfer embryos.

33. A method according to claim 31, wherein said nuclear transfer procedures comprise using a mammalian nuclear donor cells.

34. A method according to claim 33, wherein said mammalian nuclear donor cells are bovine nuclear donor cells.

35. A nucleic acid array comprising: two or more different nucleic acid molecules, the expression of which in a cell identifies said cell as a developmentally competent cell, wherein each of said different nucleic acid molecules is affixed to a solid matrix.

36. A nucleic acid array comprising: two or more different nucleic acid molecules, the expression of which in a cell identifies said cell as a developmentally incompetent cell, wherein each of said different nucleic acid molecules is affixed to a solid matrix.

37. A nucleic acid array comprising: at least one nucleic acid molecule, the expression of which in a cell identifies said cell as a developmentally competent cell; and at least one nucleic acid molecule, the expression of which in a cell identifies said cell as a developmentally incompetent cell, wherein each of said different nucleic acid molecules is affixed to a solid matrix.

38. A nucleic acid array according to any one of claims 35, 36, or 37, wherein each different nucleic acid molecule is positioned at a different spatial location on said solid matrix.

39. A nucleic acid array according to any one of claims 35, 36, or 37, wherein said solid matrix comprises a material selected from the group consisting of polyacrylamide gel, agarose gel, nitrocellulose membrane, nylon membrane, glass, magnetic materials, magnetic beads, polymeric beads, or silicon.

40. A gene expression database comprising: two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, in a stem cell identifies said stem cell as capable of committing to a specific cell lineage.

41. A gene expression database comprising: two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, in a stem cell identifies said stem cell as incapable of committing to a specific cell lineage.

42. A gene expression database comprising: at least one expressed sequence tag ("ESTs"), wherein said EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of which, or its complementary sequence, in a stem cell identifies said stem cell as capable of committing to a specific cell lineage; and at least one expressed sequence tag, wherein said EST is an isolated, enriched, or purified nucleic acid sequence representing all or part of a gene, the expression of which, or its complementary sequence, in a stem cell identifies said stem cell as incapable of committing to a specific cell lineage.

43. A method of preparing a gene expression database comprising two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, in a stem cell identifies said stem cell as capable of committing to a specific cell lineage, the method comprising: comparing a first plurality of nucleic acid molecules obtained from one or more stem cells known to be capable of differentiation into a specific cell type to a second plurality of nucleic acid molecules obtained from one or more stem cells known to be incapable of differentiation into a specific cell type; and identifying two or more nucleic acid molecules present in said first plurality of nucleic acid molecules that are not present at a detectable level in said second plurality of nucleic acid molecules.

44. A method of preparing a gene expression database comprising two or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of two or more genes, the expression of which, or their complementary sequences, in a stem cell identifies said stem cell as incapable of committing to a specific cell lineage, the method comprising: comparing a first plurality of nucleic acid molecules obtained from one or more stem cells known to be capable of differentiation into a specific cell type to a second plurality of nucleic acid molecules obtained from one or more stem cells known to be incapable of differentiation into a specific cell type; and identifying two or more nucleic acid molecules present in said second plurality of nucleic acid molecules that are not present at a detectable level in said first plurality of nucleic acid molecules.

45. A method of preparing a gene expression database comprising one or more expressed sequence tags ("ESTs"), wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of one or more genes, the expression of which, or their complementary sequences, in a stem cell identifies said stem cell as capable of committing to a specific cell lineage, and one or more expressed sequence tags, wherein said ESTs are isolated, enriched, or purified nucleic acid sequences representing all or part of one or more genes, the expression of which, or their complementary sequences, in a stem cell identifies said stem cell as incapable of committing to a specific cell lineage the method comprising: comparing a first plurality of nucleic acid molecules obtained from one or more stem cells known to be capable of differentiation into a specific cell type to a second plurality of nucleic acid molecules obtained from one or more stem cells known to be incapable of differentiation into a specific cell type; and identifying one or more nucleic acid molecules present in said first plurality of nucleic acid molecules that are not present at a detectable level in said second plurality of nucleic acid molecules, and identifying one or more nucleic acid molecules present in said second plurality of nucleic acid molecules that are not present at a detectable level in said first plurality of nucleic acid molecules.

46. A method of identifying one or more molecules that induce developmental competence in a cell line, the method comprising:

(a) contacting a developmentally incompetent cell line with one or more molecules to provide a freated cell line;

(b) separating one or more cells from said freated cell line to provide one or more separated cells; (c) performing one or more nuclear transfer procedures using each of said separated cells to provide one or more nuclear fransfer embryos; and

(d) determining the developmental competence of each of said nuclear transfer embryos by comparing a plurality of nucleic acid molecules obtained from each of said embryos to a gene expression database, whereby said comparison identifies those embryos resulting from nuclear transfer of a developmentally competent nuclear donor cell.

47. A method according to claim 46, wherein said cell line is selected from the group consisting of a cell line derived from cells isolated from an embryo arising from the union of two gametes in vitro or in vivo; an embryonic stem cell line; a cell line arising from inner cell mass cells isolated from of embryos; a cell line obtained from pre-blastocyst cells; a fetal cell line; a primordial germ cell line; a germ cell line, an embryonic germ cell line, a somatic cell line isolated from an animal; a cumulus cell line; an amniotic cell line; a fetal fibroblast cell line; a genital ridge cell line; a differentiated cell line; a lineage-specific cell line; and a totipotent cell line.

48. A method of inducing totipotence in a cell line, the method comprising:

(a) contacting said cell line with one or more molecules identified as inducing developmental incompetence in a cell line by the method of claim 46, whereby one or more cells of said cell line become developmentally competent.

49. A method of treating a disease in an animal by inducing totipotence in one or more cells ofthe animal, the method comprising:

(a) administering one or more molecules identified as inducing developmental competence in a cell line by the method of claim 46 to said animal, whereby one or more cells of said animal become developmentally competent.

50. A method according to claim 49, wherein said one or more cells are selected from the group consisting of neurons, glial cells, muscle cells, neural cells, and bone marrow cells.

51. A method of identifying one or more molecules that induce developmental incompetence in a cell line, the method comprising:

(a) contacting a developmentally competent cell line with one or more molecules to provide a freated cell line;

(b) separating one or more cells from said treated cell line to provide one or more separated cells; (c) performing one or more nuclear transfer procedures using each of said separated cells to provide one or more nuclear fransfer embryos; and

(d) determining the developmental competence of each of said nuclear transfer embryos by comparing a plurality of nucleic acid molecules obtained from each of said embryos to a gene expression database, whereby said comparison identifies those embryos resulting from nuclear transfer of a developmentally incompetent nuclear donor cell.

52. A method of preventing a full term pregnancy in an animal by inducing developmental incompetence in one or more cells in said animal, the method comprising:

(a) administering one or more molecules identified as inducing developmental incompetence in a cell line by the method of claim 51 to said animal, whereby one or more cells in said animal become developmentally incompetent.

53. A method according to claim 52, wherein said one or more cells are selected from the group consisting of spermatocytes, spermatozoa, oocytes, fertilized oocytes, and embryos.

54. A method of treating a disease in an animal by inhibiting totipotence in one or more cells ofthe animal, the method comprising:

55. A method of identifying one or more molecules that induce lineage-specific development in a stem cell line, the method comprising:

(a) contacting a stem cell line known to be incapable of differentiation into a specific cell type with one or more molecules to provide a treated cell line;

(b) determining the capability of said freated cell line to differentiate into said specific cell type by comparing a plurality of nucleic acid molecules obtained from said treated cell line to a gene expression database, whereby said comparison identifies stem cells capable of committing to a specific cell lineage.

56. A method of inducing development of a cell into a specific cell type, the method comprising:

(a) contacting a cell with one or more molecules identified as inducing lineage-specific development in a cell line by the method of claim 55, whereby said cell line develops into said specific cell type.

57. A method of freating a disease in an animal by inducing development of one or more cells ofthe animal into a specific cell type, the method comprising:

(a) administering one or more molecules identified as inducing developmental competence in a cell line by the method of claim 55 to said animal, whereby said one or more cells ofthe animal develop into said specific cell type.

58. A method of identifying one or more molecules that inhibit lineage-specific development in a stem cell line, the method comprising:

(a) contacting a stem cell line known to be capable of differentiation into a specific cell type with one or more molecules to provide a treated cell line;

(b) determining the capability of said treated cell line to differentiate into said specific cell type by comparing a plurality of nucleic acid molecules obtained from said treated cell line to a gene expression database, whereby said comparison identifies stem cells incapable of committing to a specific cell lineage.

59. A method of inhibiting development of a cell into a specific cell type, the method comprising:

(a) contactmg a cell with one or more molecules identified as inhibiting lineage-specific development in a cell line by the method of claim 58, whereby said cell line is prevented from developing into said specific cell type.

60. A method of freating a disease in an animal by inducing development of one or more cells ofthe animal into a specific cell type, the method comprising: (a) administering one or more molecules identified as inducing developmental incompetence in a cell line by the method of claim 59 to said animal, whereby said one or more cells ofthe animal are prevented from developing into said specific cell type.