AU2001264317A1 - Preparations for oligonucleotide transfer - Google Patents
Preparations for oligonucleotide transferInfo
- Publication number
- AU2001264317A1 AU2001264317A1 AU2001264317A AU6431701A AU2001264317A1 AU 2001264317 A1 AU2001264317 A1 AU 2001264317A1 AU 2001264317 A AU2001264317 A AU 2001264317A AU 6431701 A AU6431701 A AU 6431701A AU 2001264317 A1 AU2001264317 A1 AU 2001264317A1
- Authority
- AU
- Australia
- Prior art keywords
- preparations
- oligonucleotide transfer
- oligonucleotide
- transfer
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 210000004102 animal cell Anatomy 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000184502 | 2000-06-20 | ||
| JP2000-184502 | 2000-06-20 | ||
| PCT/JP2001/005195 WO2001097857A1 (en) | 2000-06-20 | 2001-06-19 | Preparations for oligonucleotide transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001264317A1 true AU2001264317A1 (en) | 2002-01-02 |
Family
ID=18684937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001264317A Abandoned AU2001264317A1 (en) | 2000-06-20 | 2001-06-19 | Preparations for oligonucleotide transfer |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20040052840A1 (en) |
| EP (1) | EP1295611B1 (en) |
| JP (1) | JP5118285B2 (en) |
| AT (1) | ATE478688T1 (en) |
| AU (1) | AU2001264317A1 (en) |
| DE (1) | DE60142899D1 (en) |
| DK (1) | DK1295611T3 (en) |
| ES (1) | ES2349137T3 (en) |
| PT (1) | PT1295611E (en) |
| WO (1) | WO2001097857A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
| EP1295611B1 (en) * | 2000-06-20 | 2010-08-25 | Dainippon Sumitomo Pharma Co., Ltd. | Oligonucleotide-transferring preparations |
| EP1407787B1 (en) * | 2001-06-20 | 2009-04-29 | Dainippon Sumitomo Pharma Co., Ltd. | Method of promoting nucleic acid transfer |
| US20100104631A1 (en) * | 2001-08-13 | 2010-04-29 | Lipella Pharmaceuticals Inc. | Method of treatment for bladder dysfunction |
| EP1550463A4 (en) * | 2002-09-20 | 2006-12-27 | Dainippon Sumitomo Pharma Co | Preparation for facilitating site-specific gene conversion and preparation for gene therapy |
| US20080318319A1 (en) * | 2003-12-19 | 2008-12-25 | Yoshiko Minakuchi | Novel Method of Nucleic Acid Transfer |
| US20090062184A1 (en) * | 2005-03-24 | 2009-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Fine particulate preparation comprising complex of nucleic acid molecule and collagen |
| US7838502B2 (en) * | 2005-05-06 | 2010-11-23 | University Of Massachusetts Medical School | Compositions and methods to modulate H. influenzae pathogenesis |
| ES2405357T3 (en) * | 2005-05-25 | 2013-05-30 | Cellmid Limited | Pharmaceutical composition for occlusive vasculopathy. |
| KR100777249B1 (en) * | 2006-02-14 | 2007-11-28 | (주)바이오니아 | Dry oligonucleotide composition and preparation method thereof |
| WO2010078403A2 (en) * | 2008-12-30 | 2010-07-08 | Lipella Pharmaceuticals Inc. | Methods and compositions for diagnosing urological disorders |
| FR3066115B1 (en) | 2017-05-10 | 2019-06-28 | Universite de Bordeaux | COMPRESSES OF NUCLEIC ACID VECTORS |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5115094B2 (en) * | 1972-11-01 | 1976-05-14 | ||
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| US5078997A (en) * | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
| US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
| US5936035A (en) * | 1988-11-21 | 1999-08-10 | Cohesion Technologies, Inc. | Biocompatible adhesive compositions |
| US5614587A (en) * | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
| JP3187410B2 (en) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | Sustained release formulation for intracerebral administration |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| FR2694895B1 (en) * | 1992-08-20 | 1994-11-10 | Coletica | Process for the production of emulsion microparticles by modification of the chemical composition of the dispersed phase after emulsification. |
| US5646042A (en) * | 1992-08-26 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | C-myb targeted ribozymes |
| ATE182336T1 (en) * | 1993-05-28 | 1999-08-15 | Chiron Corp | PEPTIDE INHIBITORS OF UROKINASE RECEPTOR ACTIVITY |
| HUT74509A (en) * | 1993-09-09 | 1997-01-28 | Schering Ag | Active principles and gas containing microparticles, their use for realising active principles in ultrasonically controlled manner, and process for preparing them |
| CA2140053C (en) * | 1994-02-09 | 2000-04-04 | Joel S. Rosenblatt | Collagen-based injectable drug delivery system and its use |
| US5942496A (en) * | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US5583034A (en) * | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| US5844107A (en) * | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US5563255A (en) * | 1994-05-31 | 1996-10-08 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
| JPH11505505A (en) * | 1994-06-27 | 1999-05-21 | ザ・ジョンズ・ホプキンス・ユニバーシティー | Targeted gene delivery system |
| JP3867160B2 (en) * | 1995-07-03 | 2007-01-10 | 大日本住友製薬株式会社 | Gene preparation |
| US6998268B2 (en) * | 1995-07-03 | 2006-02-14 | Dainippon Sumitomo Pharma Co. Ltd. | Gene preparations |
| CN1230205C (en) * | 1995-07-03 | 2005-12-07 | 株式会社高研 | gene preparation |
| CN1209068A (en) * | 1995-10-23 | 1999-02-24 | 海欧制药澳大利亚有限公司 | Hyaluronic acid as DNA carrier for gene therapy and VEGF antisense DNA to treat abnormal retinal vascularization |
| PT876165E (en) * | 1995-12-18 | 2006-10-31 | Angiotech Biomaterials Corp | COMPOSITIONS OF RETICULATED POLYMERS AND PROCESSES FOR THEIR USE |
| EP0904373A1 (en) * | 1996-03-14 | 1999-03-31 | The Immune Response Corporation | Targeted delivery of genes encoding interferon |
| US6133437A (en) * | 1997-02-13 | 2000-10-17 | Apoptogen, Inc. | Modulation of IAPs for the treatment of proliferative diseases |
| US5874006A (en) * | 1996-10-31 | 1999-02-23 | Matrix Pharmaceutical, Inc. | Aseptic collagen concentration process |
| US6042820A (en) * | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
| US6218112B1 (en) * | 1996-12-23 | 2001-04-17 | Cobra Therapeutics Limited | Optimization of gene delivery and gene delivery system |
| EP0968223B1 (en) * | 1997-01-08 | 2016-12-21 | Sigma-Aldrich Co. LLC | Bioconjugation of macromolecules |
| US6524613B1 (en) * | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| AU2868099A (en) * | 1998-02-13 | 1999-08-30 | Selective Genetics, Inc. | Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby |
| NZ508785A (en) * | 1998-05-22 | 2003-10-31 | Sumitomo Pharma | Stable gene formulations |
| EP1274410A2 (en) * | 2000-03-31 | 2003-01-15 | Trustees Of Boston University | Use of locally applied dna fragments |
| EP1295611B1 (en) * | 2000-06-20 | 2010-08-25 | Dainippon Sumitomo Pharma Co., Ltd. | Oligonucleotide-transferring preparations |
| JP2002325572A (en) * | 2000-12-25 | 2002-11-12 | Univ Osaka | How to introduce foreign substances |
| EP1407787B1 (en) * | 2001-06-20 | 2009-04-29 | Dainippon Sumitomo Pharma Co., Ltd. | Method of promoting nucleic acid transfer |
| US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| WO2004022075A1 (en) * | 2002-09-04 | 2004-03-18 | Novartis Ag | Treatment of neurological disorders by dsrna adminitration |
| EP1550463A4 (en) * | 2002-09-20 | 2006-12-27 | Dainippon Sumitomo Pharma Co | Preparation for facilitating site-specific gene conversion and preparation for gene therapy |
| CA2504926C (en) * | 2002-11-01 | 2014-01-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for sirna inhibition of hif-1 alpha |
| CA2513623A1 (en) * | 2003-01-16 | 2004-08-05 | The Trustees Of The University Of Pennsylvania | Compositions and methods for sirna inhibition of icam-1 |
| US8227434B1 (en) * | 2003-11-04 | 2012-07-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Materials and methods for treating oncological disorders |
| ES2523147T3 (en) * | 2004-02-26 | 2014-11-21 | Baylor Research Institute | Compositions and methods for the systemic treatment of arthritis |
| PL1799269T3 (en) * | 2004-09-28 | 2017-01-31 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| US8187823B2 (en) * | 2004-10-22 | 2012-05-29 | UNIVERSITé LAVAL | Modulation of neuroglia-derived BDNF in the treatment and prevention of pain |
| US7585848B2 (en) * | 2005-01-11 | 2009-09-08 | Rush University Medical Center | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
| WO2007082899A1 (en) * | 2006-01-17 | 2007-07-26 | Vib Vzw | Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration |
| US8106024B2 (en) * | 2006-06-16 | 2012-01-31 | Taisho Pharmaceutical Co., Ltd. | Method of treating cancer with an RPN2 gene expression inhibitor |
| CN101490253A (en) * | 2006-07-21 | 2009-07-22 | 赛伦斯治疗公司 | Methods for inhibiting protein kinase 3 expression |
| WO2008028085A2 (en) * | 2006-08-30 | 2008-03-06 | The Board Of Trustees Of The University Of Illinois | Modulation of mlck-l expression and uses thereof |
| CA2665202A1 (en) * | 2006-10-02 | 2008-04-10 | Aprea Ab | Compounds and methods |
| US7812002B2 (en) * | 2007-03-21 | 2010-10-12 | Quark Pharmaceuticals, Inc. | Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer |
| CN102812126A (en) * | 2009-12-04 | 2012-12-05 | 奥普科制药有限责任公司 | Compositions And Methods For Inhibition Of VEGF |
-
2001
- 2001-06-19 EP EP01938732A patent/EP1295611B1/en not_active Expired - Lifetime
- 2001-06-19 AT AT01938732T patent/ATE478688T1/en active
- 2001-06-19 WO PCT/JP2001/005195 patent/WO2001097857A1/en not_active Ceased
- 2001-06-19 US US10/311,621 patent/US20040052840A1/en not_active Abandoned
- 2001-06-19 ES ES01938732T patent/ES2349137T3/en not_active Expired - Lifetime
- 2001-06-19 DE DE60142899T patent/DE60142899D1/en not_active Expired - Lifetime
- 2001-06-19 JP JP2002503340A patent/JP5118285B2/en not_active Expired - Fee Related
- 2001-06-19 AU AU2001264317A patent/AU2001264317A1/en not_active Abandoned
- 2001-06-19 PT PT01938732T patent/PT1295611E/en unknown
- 2001-06-19 DK DK01938732.3T patent/DK1295611T3/en active
-
2009
- 2009-06-17 US US12/486,703 patent/US20090258933A1/en not_active Abandoned
-
2010
- 2010-10-13 US US12/904,054 patent/US20110028535A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001097857A1 (en) | 2001-12-27 |
| ATE478688T1 (en) | 2010-09-15 |
| ES2349137T3 (en) | 2010-12-28 |
| EP1295611B1 (en) | 2010-08-25 |
| DE60142899D1 (en) | 2010-10-07 |
| US20090258933A1 (en) | 2009-10-15 |
| JP5118285B2 (en) | 2013-01-16 |
| DK1295611T3 (en) | 2010-10-04 |
| US20040052840A1 (en) | 2004-03-18 |
| EP1295611A4 (en) | 2009-07-08 |
| US20110028535A1 (en) | 2011-02-03 |
| PT1295611E (en) | 2010-09-14 |
| EP1295611A1 (en) | 2003-03-26 |
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