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AU2001264072A1 - Method for investigating the fate of a test compound or the stateof a biologicalsystem by means of nmr of hyperpolarised nmr active nuclei - Google Patents

Method for investigating the fate of a test compound or the stateof a biologicalsystem by means of nmr of hyperpolarised nmr active nuclei

Info

Publication number
AU2001264072A1
AU2001264072A1 AU2001264072A AU6407201A AU2001264072A1 AU 2001264072 A1 AU2001264072 A1 AU 2001264072A1 AU 2001264072 A AU2001264072 A AU 2001264072A AU 6407201 A AU6407201 A AU 6407201A AU 2001264072 A1 AU2001264072 A1 AU 2001264072A1
Authority
AU
Australia
Prior art keywords
nmr
fate
test compound
methods
biologicalsystem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264072A
Inventor
Jan Henrik Ardenkjaer-Larsen
Nigel Bosworth
Neil Cook
Klaes Golman
Peter Knox
Mike Looker
Albie Santos
Jan Wolber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Amersham PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham PLC filed Critical Amersham PLC
Publication of AU2001264072A1 publication Critical patent/AU2001264072A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.
AU2001264072A 2000-06-14 2001-06-12 Method for investigating the fate of a test compound or the stateof a biologicalsystem by means of nmr of hyperpolarised nmr active nuclei Abandoned AU2001264072A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0014463 2000-06-14
GBGB0014463.4A GB0014463D0 (en) 2000-06-14 2000-06-14 NMR Method
PCT/GB2001/002559 WO2001096895A1 (en) 2000-06-14 2001-06-12 Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei

Publications (1)

Publication Number Publication Date
AU2001264072A1 true AU2001264072A1 (en) 2001-12-24

Family

ID=9893582

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001264072A Abandoned AU2001264072A1 (en) 2000-06-14 2001-06-12 Method for investigating the fate of a test compound or the stateof a biologicalsystem by means of nmr of hyperpolarised nmr active nuclei

Country Status (8)

Country Link
US (1) US8372654B2 (en)
EP (1) EP1290461B1 (en)
JP (1) JP4993424B2 (en)
AT (1) ATE549637T1 (en)
AU (1) AU2001264072A1 (en)
ES (1) ES2381335T3 (en)
GB (1) GB0014463D0 (en)
WO (1) WO2001096895A1 (en)

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US6696040B2 (en) * 2000-07-13 2004-02-24 Medi-Physics, Inc. Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo
ATE336727T1 (en) 2000-11-03 2006-09-15 Amersham Health As METHOD AND DEVICE FOR DISSOLVING HYPERPOLARIZED SOLIDS FOR NMR ANALYSIS
US7126332B2 (en) * 2001-07-20 2006-10-24 Baker Hughes Incorporated Downhole high resolution NMR spectroscopy with polarization enhancement
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
CA2424112C (en) * 2002-04-02 2010-06-15 Baker Hughes Incorporated A method and apparatus for combined nmr and formation testing for assessing relative permeability with formation testing and nuclear magnetic resonance testing
NO20023357D0 (en) 2002-04-19 2002-07-11 Amersham Health As Mixture
NO20023358D0 (en) * 2002-04-19 2002-07-11 Amersham Health As Method
WO2004034049A1 (en) * 2002-10-09 2004-04-22 Waters Investments Limited Methods and apparatus for identifying compounds in a sample
NO20025738D0 (en) * 2002-11-29 2002-11-29 Amersham Health As Method
GB0308586D0 (en) 2003-04-14 2003-05-21 Amersham Health R & D Ab Method and arrangements in NMR spectroscopy
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
NO20035626D0 (en) * 2003-12-17 2003-12-17 Amersham Health As Method
EP1555538A1 (en) * 2004-01-15 2005-07-20 Bruker BioSpin MRI GmbH Method of fast multidimensional NMR spectroscopy
MX2007001035A (en) * 2004-07-30 2007-07-11 Ge Healthcare As Method of producing a composition, composition and its use.
US20080287774A1 (en) * 2005-11-06 2008-11-20 Rachel Katz-Brull Magnetic Resonance Imaging and Spectroscopy Means and Methods Thereof
ATE534407T1 (en) 2005-12-01 2011-12-15 Ge Healthcare As METHOD FOR DYNAMIC NUCLEAR POLARIZATION (DNP) USING A TRITYL RESIDUE AND A PARAMAGNETIC METAL ION
US8273874B2 (en) 2006-08-30 2012-09-25 Ge Healthcare As Method of dynamic nuclear polarisation (DNP) and compounds and compositions for use in the method
US8812076B2 (en) 2006-11-21 2014-08-19 General Electric Company Proton decoupled hyperpolarized magnetic resonance imaging
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP2011519554A (en) 2008-05-02 2011-07-14 ゼネラル・エレクトリック・カンパニイ Method for measuring alanine transaminase (ALT) activity by 13C-MR detection using hyperpolarized 13C-pyruvate
US20110274626A1 (en) 2008-12-10 2011-11-10 University Of York Pulse sequencing with hyperpolarisable nuclei
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
JP5744032B2 (en) * 2009-09-10 2015-07-01 ジーイー・ヘルスケア・リミテッド 13C-MR detection using hyperpolarized 13C-fructose
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
KR101858269B1 (en) 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 Hyperpolarized lactate contrast agent for determination of ldh activity
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
EP2788035B1 (en) 2011-12-05 2016-03-09 Bracco Imaging S.p.A Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
CN104198517B (en) * 2014-09-23 2017-02-08 中国科学院昆明植物研究所 Quantitative method of one-dimensional nuclear magnetic resonance mixture jointly utilizing different nucleuses
JP6923837B2 (en) 2015-06-29 2021-08-25 国立研究開発法人理化学研究所 Method for high polarization of nuclear spin by dynamic nuclear polarization using soluble pentacene
EP3316912B1 (en) 2015-06-30 2022-11-30 Technion Research & Development Foundation Ltd. Method for preparation of a sample containing highly polarized nuclear spins
CN105092628B (en) * 2015-07-21 2017-05-31 中国农业科学院农业质量标准与检测技术研究所 A kind of method for differentiating milk products quality
GB2552452A (en) * 2016-05-23 2018-01-31 Creo Medical Ltd Electrosurgical apparatus and method for promoting haemostasis in biological tissue
CN106404818B (en) * 2016-08-31 2018-01-23 安徽省农业科学院畜牧兽医研究所 A kind of method of fresh milk freshness detection
US11016044B2 (en) * 2017-08-23 2021-05-25 Osaka University Nuclear spin hyperpolarization method and apparatus
US10677874B2 (en) * 2018-02-20 2020-06-09 Wisconsin Alumni Research Foundation System and method for control of hyperpolarized gas-phase contamination in spectroscopic magnetic resonance imaging
WO2021156063A1 (en) * 2020-02-07 2021-08-12 Ecole Polytechnique Federale De Lausanne (Epfl) Method for the preparation of a sample comprising highly polarized nuclear spins and uses and devices for such a method

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US5433196A (en) * 1993-06-02 1995-07-18 The Board Of Trustees Of The University Of Illinois Oxygen-17 NMR spectroscopy and imaging in the human
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5642625A (en) * 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas
WO1997037239A1 (en) * 1996-03-29 1997-10-09 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
GB9706282D0 (en) * 1997-03-26 1997-05-14 Nycomed Imaging As Method
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Also Published As

Publication number Publication date
US8372654B2 (en) 2013-02-12
JP4993424B2 (en) 2012-08-08
ATE549637T1 (en) 2012-03-15
ES2381335T3 (en) 2012-05-25
US20040039281A1 (en) 2004-02-26
WO2001096895A1 (en) 2001-12-20
GB0014463D0 (en) 2000-08-09
EP1290461A1 (en) 2003-03-12
JP2004503786A (en) 2004-02-05
EP1290461B1 (en) 2012-03-14

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