AU2001261707A1 - Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives - Google Patents

Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives

Info

Publication number: AU2001261707A1
Authority: AU; Australia
Prior art keywords: pirazino; pyrido; indole derivatives; compounds; indole
Prior art date: 2000-06-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001261707A

Other languages

English (en)

Inventor

Alain Claude-Marie Daugan

Francoise Gellibert

Mark W. Orme

Jason Scott Sawyer

Lisa M. Schultze

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lilly Icos LLC

Original Assignee

Lilly Icos LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-05-15

Publication date

2002-01-08

2001-05-15 Application filed by Lilly Icos LLC filed Critical Lilly Icos LLC

2002-01-08 Publication of AU2001261707A1 publication Critical patent/AU2001261707A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AU2001261707A 2000-06-23 2001-05-15 Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives Abandoned AU2001261707A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US21364700P	2000-06-23	2000-06-23
US60/213,647		2000-06-23
PCT/US2001/015935 WO2002000656A2 (fr)	2000-06-23	2001-05-15	Composes chimiques

Publications (1)

Publication Number	Publication Date
AU2001261707A1 true AU2001261707A1 (en)	2002-01-08

Family

ID=22795930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001261707A Abandoned AU2001261707A1 (en)	2000-06-23	2001-05-15	Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives

Country Status (10)

Country	Link
US (1)	US6911542B2 (fr)
EP (1)	EP1366049B1 (fr)
JP (1)	JP4169149B2 (fr)
AT (1)	ATE330958T1 (fr)
AU (1)	AU2001261707A1 (fr)
CA (1)	CA2412594C (fr)
DE (1)	DE60121048T2 (fr)
ES (1)	ES2269401T3 (fr)
MX (1)	MXPA02012472A (fr)
WO (1)	WO2002000656A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003252259A1 (en) *	2002-07-26	2004-02-16	Nihon Nohyaku Co., Ltd.	Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof
JP2004107323A (ja) *	2002-07-26	2004-04-08	Nippon Nohyaku Co Ltd	新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
US7449462B2 (en)	2004-01-22	2008-11-11	Pfizer, Inc.	Triazole derivatives which inhibit vasopressin antagonistic activity
CN101106997A (zh)	2004-08-17	2008-01-16	约翰·霍普金斯大学	Pde5抑制剂组合物及治疗心脏病征候的方法
US20060276652A1 (en) *	2005-04-12	2006-12-07	Ben-Zion Dolitzky	Preparation of tadalafil intermediates
ES2700989T3 (es)	2012-12-21	2019-02-20	Mayo Found Medical Education & Res	Métodos y materiales para tratar estenosis de la válvula aórtica calcificada
JP2016539086A (ja) *	2013-10-07	2016-12-15	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	乳癌耐性タンパク質（ｂｃｒｐ）の阻害剤
CN106279164B (zh) *	2015-06-26	2019-11-01	重庆迪康尔乐制药有限公司	5型磷酸二酯酶抑制剂及其应用
KR102457316B1 (ko) *	2015-06-26	2022-10-20	총킹 디캉 에릴 파마 씨오. 엘티디.	새로운 5형포스포디에스테라아제 억제제 및 그 용도
CN105384740A (zh) *	2015-12-18	2016-03-09	海南通用康力制药有限公司	一种制备他达拉非的中间体高纯度晶体及制备方法
MX2021012409A (es)	2019-04-10	2021-11-12	Mayo Found Medical Education & Res	Metodos y materiales para el tratamiento dependiente del genero de la disfuncion cardiovascular.
CN119390695A (zh) *	2024-12-31	2025-02-07	威胜生物医药(苏州)股份有限公司	一种水溶性氨基他达那非衍生物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514464D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Medicaments

2001
- 2001-05-15 US US10/297,682 patent/US6911542B2/en not_active Expired - Fee Related
- 2001-05-15 EP EP01935629A patent/EP1366049B1/fr not_active Expired - Lifetime
- 2001-05-15 JP JP2002505780A patent/JP4169149B2/ja not_active Expired - Fee Related
- 2001-05-15 DE DE60121048T patent/DE60121048T2/de not_active Expired - Lifetime
- 2001-05-15 ES ES01935629T patent/ES2269401T3/es not_active Expired - Lifetime
- 2001-05-15 CA CA002412594A patent/CA2412594C/fr not_active Expired - Fee Related
- 2001-05-15 AU AU2001261707A patent/AU2001261707A1/en not_active Abandoned
- 2001-05-15 MX MXPA02012472A patent/MXPA02012472A/es active IP Right Grant
- 2001-05-15 AT AT01935629T patent/ATE330958T1/de not_active IP Right Cessation
- 2001-05-15 WO PCT/US2001/015935 patent/WO2002000656A2/fr not_active Ceased

Also Published As

Publication number	Publication date
EP1366049B1 (fr)	2006-06-21
JP4169149B2 (ja)	2008-10-22
EP1366049A2 (fr)	2003-12-03
MXPA02012472A (es)	2004-01-26
JP2004513072A (ja)	2004-04-30
CA2412594C (fr)	2009-03-17
WO2002000656A2 (fr)	2002-01-03
DE60121048D1 (de)	2006-08-03
ATE330958T1 (de)	2006-07-15
US20030225094A1 (en)	2003-12-04
WO2002000656A3 (fr)	2003-10-02
US6911542B2 (en)	2005-06-28
DE60121048T2 (de)	2007-01-25
ES2269401T3 (es)	2007-04-01
CA2412594A1 (fr)	2002-01-03

Publication	Publication Date	Title
AU2002246728A1 (en)	2002-08-28	Carboline derivatives
WO2001094345A3 (fr)	2002-07-18	Composes chimiques
AU2002249890A1 (en)	2002-08-28	Carboline derivatives
AU2002213421A1 (en)	2002-04-15	Condensed pyridoindole derivatives
WO1996032003A3 (fr)	1997-01-03	Tetrahydro-imidazopyrido-indolediones et leur utilisation en tant que medicaments
AU2001266575A1 (en)	2002-01-08	Chemical compounds
NO20025821L (no)	2003-02-04	2-aminokarbonyl-9H-purinderivater
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
MXPA03008215A (es)	2004-01-29	Inhibidores de integrina alfa v beta 6.
WO2002070469A3 (fr)	2004-03-04	Inhibiteurs selectifs de pde3b et leurs utilisations therapeutiques
AU2002213419A1 (en)	2002-04-15	Condensed pyridoindole derivatives
AU2001261707A1 (en)	2002-01-08	Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
AU2001263278A1 (en)	2002-01-08	Cyclic gmp-specific phosphodiesterase inhibitors
AU2002211493A1 (en)	2002-05-15	Indole derivatives as pde5-inhibitors
AU2001296699A1 (en)	2002-05-21	Condensed pyrazindione derivatives as pde inhibitors
AU2001292698A1 (en)	2002-04-15	Hexahydropyrazino `1'2' : 1, 6!- pyrido `3, 4-b! indole-1, 4-dione derivatives for the treatment of cardiovascular disorders and erectile disfunction
CA2423357A1 (fr)	2002-02-07	Derives heterocycliques fusionnes utilises comme inhibiteurs de phosphodiesterase
CA2445620A1 (fr)	2002-12-12	Composes tetracycliques utilises comme inhibiteurs de pde5-