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AU2001260445A1 - Triterpenoid derivatives - Google Patents

Triterpenoid derivatives

Info

Publication number
AU2001260445A1
AU2001260445A1 AU2001260445A AU6044501A AU2001260445A1 AU 2001260445 A1 AU2001260445 A1 AU 2001260445A1 AU 2001260445 A AU2001260445 A AU 2001260445A AU 6044501 A AU6044501 A AU 6044501A AU 2001260445 A1 AU2001260445 A1 AU 2001260445A1
Authority
AU
Australia
Prior art keywords
compound
formula
relates
present
triterpenoid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001260445A
Inventor
Jan Sarek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Matematicko-Fyzikalni Fakulta University Karlovy V Praze
Palacky University Olomouc
Original Assignee
Matematicko-Fyzikalni Fakulta University Karlovy V Praze
Palacky University Olomouc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matematicko-Fyzikalni Fakulta University Karlovy V Praze, Palacky University Olomouc filed Critical Matematicko-Fyzikalni Fakulta University Karlovy V Praze
Publication of AU2001260445A1 publication Critical patent/AU2001260445A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in therapy. Prefereably, the compound may be used for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further embodiment relates to the use of a compound of formula (I) in an assay for detecting the phosphorylation and acetylation state of cellular substrates. The present invention also relates to novel compounds of formula (Ia).
AU2001260445A 2000-05-23 2001-05-23 Triterpenoid derivatives Abandoned AU2001260445A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0012526.0 2000-05-23
GB0012526A GB2362648A (en) 2000-05-23 2000-05-23 Triterpenoid derivatives
PCT/GB2001/002313 WO2001090136A2 (en) 2000-05-23 2001-05-23 Triterpenoid derivatives

Publications (1)

Publication Number Publication Date
AU2001260445A1 true AU2001260445A1 (en) 2001-12-03

Family

ID=9892207

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001260445A Abandoned AU2001260445A1 (en) 2000-05-23 2001-05-23 Triterpenoid derivatives

Country Status (8)

Country Link
US (2) US7041701B2 (en)
EP (1) EP1294370B1 (en)
AT (1) ATE305776T1 (en)
AU (1) AU2001260445A1 (en)
DE (1) DE60113838T2 (en)
ES (1) ES2250406T3 (en)
GB (1) GB2362648A (en)
WO (1) WO2001090136A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
US6720445B2 (en) 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
GB0128071D0 (en) * 2001-11-22 2002-01-16 Cyclacel Ltd Medicament
JPWO2003057224A1 (en) * 2001-12-28 2005-08-25 日清オイリオグループ株式会社 Apoptosis inducer
EP2269998A3 (en) 2004-08-19 2011-03-30 DSM IP Assets B.V. Process for the rectification of mixtures of high-boiling air- and/or temperature-sensitive useful products
GB0419416D0 (en) * 2004-09-01 2004-10-06 Inst Of Ex Botany Ascr 4-Arylazo-3,5-Diamino-Pyrazole compounds and use thereof
CZ300722B6 (en) * 2006-09-27 2009-07-22 Univerzita Karlova v Praze, Prírodovedecká fakulta Process for preparing inclusion complex of pentacyclic and tetracyclic terpenoids, process for preparing pharmaceutical composition containing this inclusion complex, inclusion complex of pentacyclic or tetracyclic terpenoid and pharmaceutical compos
US9012439B2 (en) * 2007-10-29 2015-04-21 University Of Rochester Use of electrophilic compounds for inducing platelet production or maintaining platelet function
JP5320530B2 (en) * 2008-02-14 2013-10-23 秋田県 Triterpene compound useful as anticancer agent and anticancer composition using the triterpene compound
CZ2008528A3 (en) * 2008-09-01 2009-11-18 Univerzita Karlova v Praze, Prírodovedecká fakulta Triterpenoid derivatives for treating tumor diseases and pharmaceutical composition in which the derivatives are comprised
CZ301318B6 (en) 2008-11-13 2010-01-13 Univerzita Palackého v Olomouci 2-Deoxyglycosides of triterpenoids, process of their preparation and their use as medicament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2810758A (en) * 1955-05-26 1957-10-22 Wisconsin Alumni Res Found Steroid and intermediate compounds
CH602794A5 (en) * 1974-10-29 1978-08-15 Hoffmann La Roche
IL50854A (en) * 1975-11-11 1979-12-30 Sparamedica Ag D-homosteroids their manufacture and pharmaceutical compositions containing them
US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US6048847A (en) * 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this

Also Published As

Publication number Publication date
GB0012526D0 (en) 2000-07-12
EP1294370A2 (en) 2003-03-26
ATE305776T1 (en) 2005-10-15
WO2001090136A3 (en) 2003-01-16
EP1294370B1 (en) 2005-10-05
US20060160890A1 (en) 2006-07-20
US20040266868A1 (en) 2004-12-30
DE60113838D1 (en) 2006-02-16
ES2250406T3 (en) 2006-04-16
US7041701B2 (en) 2006-05-09
WO2001090136A2 (en) 2001-11-29
US7749988B2 (en) 2010-07-06
GB2362648A (en) 2001-11-28
DE60113838T2 (en) 2006-06-08

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