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AU2001256958A1 - Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use - Google Patents

Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use

Info

Publication number
AU2001256958A1
AU2001256958A1 AU2001256958A AU5695801A AU2001256958A1 AU 2001256958 A1 AU2001256958 A1 AU 2001256958A1 AU 2001256958 A AU2001256958 A AU 2001256958A AU 5695801 A AU5695801 A AU 5695801A AU 2001256958 A1 AU2001256958 A1 AU 2001256958A1
Authority
AU
Australia
Prior art keywords
collagen
reactive
identification
cross
binding proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001256958A
Other languages
English (en)
Inventor
Fabrizia Casolini
Paul Domanski
Magnus Hook
Pratiksha Patel
Joseph Patti
Pietro Speziale
Livia Visai
Yi Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Pavia
Texas A&M University System
Inhibitex Inc
Original Assignee
Universita degli Studi di Pavia
Texas A&M University System
Inhibitex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Pavia, Texas A&M University System, Inhibitex Inc filed Critical Universita degli Studi di Pavia
Publication of AU2001256958A1 publication Critical patent/AU2001256958A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/085Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2001256958A 2000-03-17 2001-03-19 Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Abandoned AU2001256958A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18996800P 2000-03-17 2000-03-17
US60189968 2000-03-17
US19937000P 2000-04-25 2000-04-25
US60199370 2000-04-25
US22540200P 2000-08-15 2000-08-15
US60225402 2000-08-15
PCT/US2001/008554 WO2001070267A1 (fr) 2000-03-17 2001-03-19 Anticorps de deplacement a reaction croisee provenant des proteines de liaison du collagene et procede d'identification et d'utilisation

Publications (1)

Publication Number Publication Date
AU2001256958A1 true AU2001256958A1 (en) 2001-10-03

Family

ID=27392662

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001256958A Abandoned AU2001256958A1 (en) 2000-03-17 2001-03-19 Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use

Country Status (6)

Country Link
US (1) US7241592B2 (fr)
EP (1) EP1267930A4 (fr)
JP (1) JP2003527440A (fr)
AU (1) AU2001256958A1 (fr)
CA (1) CA2403359A1 (fr)
WO (1) WO2001070267A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072607A1 (fr) * 2002-02-21 2003-09-04 Università Degli Studi Di Pavia Anticorps monoclonaux a reaction croisee contre des proteines de liaison de collagene bacterien
CA2478029A1 (fr) * 2002-03-05 2003-09-18 Inhibitex, Inc. Anticorps monoclonaux et polyclonaux reconnaissant des proteines staphylocoques a coagulase negative
EA018030B1 (ru) * 2006-06-06 2013-05-30 Круселл Холланд Б.В. Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения
WO2008089476A1 (fr) * 2007-01-19 2008-07-24 Inhibitex, Inc. Anticorps monoclonaux reconnaissant la protéine acm d'enterococcus faecium
JP5249326B2 (ja) 2007-07-23 2013-07-31 ワクチン リサーチ インターナショナル ピーエルシー 不活化ブドウ球菌全細胞ワクチン
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
CA2697538C (fr) 2007-08-31 2019-02-12 University Of Chicago Procedes et compositions associees pour immuniser contre des maladies et des etats staphylococciques des poumons
US8758765B2 (en) 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
US8465751B2 (en) 2009-01-12 2013-06-18 Novartis Ag Cna—B domain antigens in vaccines against gram positive bacteria
SMT202000246T1 (it) 2009-04-03 2020-07-08 Univ Chicago Composizioni e metodi relativi a varianti della proteina a (spa)
BR112013000097B1 (pt) 2010-07-02 2022-02-01 The University Of Chicago Polipeptídeo imunogênico isolado, composição imunogênica e seu uso
US9176135B2 (en) 2010-08-22 2015-11-03 University Of Rochester Method for predicting and preventing cardiovascular disease
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
US11446371B2 (en) 2015-11-05 2022-09-20 The Texas A&M University System Targeting of ligand binding sites in ClfA

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997043314A2 (fr) * 1996-05-16 1997-11-20 The Texas A & M University System Compositions de proteine de liaison du collagene et procedes d'utilisation

Also Published As

Publication number Publication date
JP2003527440A (ja) 2003-09-16
WO2001070267A1 (fr) 2001-09-27
CA2403359A1 (fr) 2001-09-27
US20070122416A1 (en) 2007-05-31
EP1267930A4 (fr) 2005-01-19
EP1267930A1 (fr) 2003-01-02
US7241592B2 (en) 2007-07-10

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