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AU2001254576A1 - Resolution of aminotetralins - Google Patents

Resolution of aminotetralins

Info

Publication number
AU2001254576A1
AU2001254576A1 AU2001254576A AU5457601A AU2001254576A1 AU 2001254576 A1 AU2001254576 A1 AU 2001254576A1 AU 2001254576 A AU2001254576 A AU 2001254576A AU 5457601 A AU5457601 A AU 5457601A AU 2001254576 A1 AU2001254576 A1 AU 2001254576A1
Authority
AU
Australia
Prior art keywords
stereoisomers
aminotetralins
resolution
lipase
separable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001254576A
Inventor
Trina Cherryle Cosway
Kanjai Khumtaveeporn
Wen-Lung Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torcan Chemical Ltd
Original Assignee
Torcan Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd
Publication of AU2001254576A1 publication Critical patent/AU2001254576A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Stereoisomers of carbocyclic amine compounds such as amino tetralins are separated by subjecting a mixture of the stereoisomers to reaction with an acylating agent in the presence of the enzyme Pseudomonas capacia lipase which effect selective acylation of one of the stereoisomers to form a separable amide, whilst leaving the other stereoisomer substantially unchanged.
AU2001254576A 2000-05-01 2001-04-30 Resolution of aminotetralins Abandoned AU2001254576A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA2307390 2000-01-05
CA002307390A CA2307390C (en) 2000-05-01 2000-05-01 Enzymatic resolution of aminotetralins
PCT/CA2001/000625 WO2001083807A1 (en) 2000-05-01 2001-04-30 Resolution of aminotetralins

Publications (1)

Publication Number Publication Date
AU2001254576A1 true AU2001254576A1 (en) 2001-11-12

Family

ID=4166052

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001254576A Abandoned AU2001254576A1 (en) 2000-05-01 2001-04-30 Resolution of aminotetralins

Country Status (11)

Country Link
US (1) US6271005B1 (en)
EP (1) EP1278885B1 (en)
JP (1) JP2003531624A (en)
AT (1) ATE269413T1 (en)
AU (1) AU2001254576A1 (en)
CA (2) CA2307390C (en)
DE (1) DE60103887T2 (en)
DK (1) DK1278885T3 (en)
ES (1) ES2222366T3 (en)
PT (1) PT1278885E (en)
WO (1) WO2001083807A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100423875B1 (en) * 2001-12-06 2004-03-22 주식회사 포스코 Method for preparing chiral amines
US8729306B2 (en) 2010-02-05 2014-05-20 Ucb Pharma Gmbh Process for the preparation of nitrogen substituted aminotetralins derivatives
BR112012029944A2 (en) * 2010-06-25 2019-09-24 Ucb Pharma Gmbh process for preparing nitrogen substituted aminotetralines derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904392D0 (en) 1989-02-27 1989-04-12 Ibm An arithmetic logic unit for a graphics processor
AU654653B2 (en) 1989-05-31 1994-11-17 Pharmacia & Upjohn Company Therapeutically useful 2-aminotetralin derivatives
US5300437A (en) 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US4968837A (en) 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures

Also Published As

Publication number Publication date
DK1278885T3 (en) 2004-10-18
CA2307390C (en) 2005-06-28
DE60103887T2 (en) 2005-06-23
DE60103887D1 (en) 2004-07-22
PT1278885E (en) 2004-09-30
CA2307390A1 (en) 2001-11-01
JP2003531624A (en) 2003-10-28
WO2001083807A1 (en) 2001-11-08
EP1278885B1 (en) 2004-06-16
ES2222366T3 (en) 2005-02-01
CA2407776A1 (en) 2001-11-08
EP1278885A1 (en) 2003-01-29
US6271005B1 (en) 2001-08-07
ATE269413T1 (en) 2004-07-15

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