AU2001249670A1 - Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1 - Google Patents
Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1Info
- Publication number
- AU2001249670A1 AU2001249670A1 AU2001249670A AU4967001A AU2001249670A1 AU 2001249670 A1 AU2001249670 A1 AU 2001249670A1 AU 2001249670 A AU2001249670 A AU 2001249670A AU 4967001 A AU4967001 A AU 4967001A AU 2001249670 A1 AU2001249670 A1 AU 2001249670A1
- Authority
- AU
- Australia
- Prior art keywords
- activatorinhibitor
- plasminogen
- inhibitors
- substituted thiazoles
- thiazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 title 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003557 thiazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19450500P | 2000-04-03 | 2000-04-03 | |
| US60194505 | 2000-04-03 | ||
| PCT/US2001/010307 WO2001074793A2 (fr) | 2000-04-03 | 2001-04-02 | Thiazoles substitues et utilisation associee en tant qu'inhibiteurs de l'inhibiteur-1 d'activateur de plasminogene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001249670A1 true AU2001249670A1 (en) | 2001-10-15 |
Family
ID=22717856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001249670A Abandoned AU2001249670A1 (en) | 2000-04-03 | 2001-04-02 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1 |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US6586453B2 (fr) |
| AU (1) | AU2001249670A1 (fr) |
| WO (1) | WO2001074793A2 (fr) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1309576B1 (fr) * | 2000-08-07 | 2017-11-22 | OSRAM OLED GmbH | Derives de di(het)arylaminothiazol et leur utilisation dans des diodes electroluminescentes organiques (delo) et composants photovolta ques organiques |
| US6348380B1 (en) * | 2000-08-25 | 2002-02-19 | Micron Technology, Inc. | Use of dilute steam ambient for improvement of flash devices |
| JP3836019B2 (ja) * | 2001-11-21 | 2006-10-18 | 松下電器産業株式会社 | 受信装置、送信装置及び送信方法 |
| GB0130007D0 (en) * | 2001-12-14 | 2002-02-06 | Novartis Forschungsstiftung | Screening method for agents useful in treating diabetes |
| EP1465882B1 (fr) * | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Modulateurs heterocycliques de recepteurs nucleaires |
| US7220764B2 (en) * | 2002-06-17 | 2007-05-22 | The Pennsylvania State University Research Foundation | Sphingosine kinase inhibitors |
| US8450302B2 (en) * | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| EP1525200B1 (fr) * | 2002-08-02 | 2007-10-10 | AB Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles et leur utilisation en tant que inhibiteurs de c-kit |
| ES2332135T3 (es) * | 2003-06-03 | 2010-01-27 | Novartis Ag | Inhibidores p-38 basados en heterociclo de 5 miembros. |
| US7550499B2 (en) * | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| DE102004034697A1 (de) * | 2004-07-17 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Mit Diphenylamin oder Diphenylaminderivaten substituierte Salicylthiazole, Verfahren zu deren Herstellung und deren Verwendung |
| KR20070055563A (ko) * | 2004-08-23 | 2007-05-30 | 와이어쓰 | 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산 |
| CA2577782A1 (fr) * | 2004-08-23 | 2006-03-02 | Wyeth | Acides pyrrolo-naphtyliques en tant qu'inhibiteurs du pai-1 |
| BRPI0514572A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de tiazolo-naftila |
| ATE499370T1 (de) * | 2005-01-19 | 2011-03-15 | Bristol Myers Squibb Co | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen |
| KR100689961B1 (ko) | 2005-03-04 | 2007-03-08 | 한국화학연구원 | 4-(3,4-디알콕시페닐)-2-아미노티아졸 화합물, 이의 제조방법 및 이를 포함하는 천식, 만성폐쇄성 폐질환을 포함한 염증관련 질환 및 알쯔하이머를 포함한 중추신경계통의 질환의 치료제 조성물 |
| KR20080019213A (ko) * | 2005-05-09 | 2008-03-03 | 아칠리온 파르마세우티칼스 인코포레이티드 | 티아졸 화합물 및 그 사용방법 |
| DE602006017694D1 (de) * | 2005-06-27 | 2010-12-02 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
| KR20080027890A (ko) * | 2005-06-27 | 2008-03-28 | 브리스톨-마이어스 스큅 컴퍼니 | 혈전성 증상의 치료에 유용한 ｐ2ｙ1 수용체의 ｎ-연결헤테로시클릭 길항제 |
| US7714002B2 (en) * | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| ATE502924T1 (de) | 2005-06-27 | 2011-04-15 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden |
| JP5341516B2 (ja) * | 2005-09-13 | 2013-11-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ２−アニリン−４−アリール置換チアゾール誘導体 |
| WO2007084391A2 (fr) * | 2006-01-18 | 2007-07-26 | Amgen Inc. | Composes thiazole et procedes d'utilisation |
| CA2641734A1 (fr) * | 2006-02-15 | 2007-08-23 | Abbott Laboratories | Inhibiteurs de l'acetyl-coa carboxylase (acc) et leur utilisation dans les traitements du diabete, de l'obesite et d'un syndrome metabolique |
| WO2007095603A2 (fr) * | 2006-02-15 | 2007-08-23 | Abbott Laboratories | Nouveaux inhibiteurs d'acétyl-coa carboxylase (acc) et leur utilisation dans le traitement du diabète, de l'obésité et du syndrome métabolique |
| CN101096363B (zh) | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
| US7960569B2 (en) * | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| MX2009012613A (es) | 2007-05-22 | 2010-04-21 | Achillion Pharmaceuticals Inc | Tiazoles substituidos por heteroarilo y su uso como agentes antivirales. |
| US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
| AU2008276512A1 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された１，２，４−トリアゾール |
| NZ587669A (en) | 2008-03-19 | 2011-07-29 | Janssen Pharmaceutica Nv | Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators |
| JP2011519372A (ja) * | 2008-04-30 | 2011-07-07 | フレードリク・アルムクヴィスト | 新規ペプチド摸倣化合物 |
| EP2280945B1 (fr) | 2008-05-09 | 2014-09-03 | Janssen Pharmaceutica, N.V. | Pyrazoles trisubstitués en tant que modulateurs des récepteurs de l'acétylcholine |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| US20140105867A1 (en) * | 2011-03-23 | 2014-04-17 | University Of Florida Research Foundation. Inc. | Blockage of pai-1 in diabetic cd34+ stem cells corrects cellular dysfunction |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| EP3070085B1 (fr) | 2013-02-04 | 2019-01-09 | Janssen Pharmaceutica NV | Modulateurs à volet |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| US9290484B2 (en) * | 2013-02-22 | 2016-03-22 | Rutgers, The State University Of New Jersey | Furyl and thienyl triazole derivatives and therapeutic uses thereof |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| US11472781B2 (en) | 2018-02-21 | 2022-10-18 | Southern Research Institute | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases |
| WO2019222497A1 (fr) | 2018-05-17 | 2019-11-21 | Southern Research Institute | Analogues du 2,5-aryl-thiazole pour le traitement de maladies neurodégénératives |
| US11608329B2 (en) | 2019-12-20 | 2023-03-21 | Ikena Oncology, Inc. | Aryl hydrocarbon receptor (AHR) agonists and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299087A (en) | 1961-04-24 | 1967-01-17 | Geigy Chem Corp | Nu, nu'-bis-(thiazolyl)-phenylenediamines |
| US3201409A (en) * | 1961-04-24 | 1965-08-17 | John D Spivack | 2-substituted aminothiazoles |
| US3467666A (en) | 1966-11-07 | 1969-09-16 | Geigy Chem Corp | 2-substituted aminothiazoles |
| US4001420A (en) * | 1968-12-12 | 1977-01-04 | Science Union Et Cie, Societe Francaise De Recherche Medical | Thiazolyl benzoic acid compounds |
| US4942242A (en) * | 1983-06-24 | 1990-07-17 | Tadao Kojima | Certain thiazol-4-yl-phenoxy derivatives having lipid lowering properties |
| US5217971A (en) * | 1989-01-05 | 1993-06-08 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds and pharmaceutical composition comprising the same |
| DE4029771A1 (de) | 1990-09-20 | 1992-03-26 | Basf Ag | N-heteroaryl-2-nitroaniline |
| JPH07500116A (ja) | 1992-03-26 | 1995-01-05 | ダウエランコ | 殺菌剤としてのｎ−複素環式ニトロアニリン |
| US5342851A (en) | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
| US5530000A (en) | 1993-12-22 | 1996-06-25 | Ortho Pharmaceutical Corporation | Substituted pyrimidinylaminothiazole derivatives useful as platelet aggreggation inhibitors |
| US5731328A (en) | 1995-10-10 | 1998-03-24 | Eli Lilly And Company | Methods of inhibiting plasminogen activator inhibitor 1 |
| US5792798A (en) | 1996-07-29 | 1998-08-11 | Eli Lilly And Company | Method for inhibiting plasminogen activator inhibitor 1 |
-
2001
- 2001-04-02 WO PCT/US2001/010307 patent/WO2001074793A2/fr not_active Ceased
- 2001-04-02 US US09/822,351 patent/US6586453B2/en not_active Expired - Lifetime
- 2001-04-02 AU AU2001249670A patent/AU2001249670A1/en not_active Abandoned
-
2003
- 2003-04-22 US US10/419,970 patent/US20030220380A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030220380A1 (en) | 2003-11-27 |
| WO2001074793A3 (fr) | 2002-05-16 |
| WO2001074793A2 (fr) | 2001-10-11 |
| US20010044545A1 (en) | 2001-11-22 |
| US6586453B2 (en) | 2003-07-01 |
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